Motoneurone survival activity in extracts of denervated muscle reduced by prior stimulation of the muscle.
Inactivation of skeletal muscle by denervation increases motoneurone survival activity in extracts of skeletal muscle. The present investigation shows that electrical stimulation of denervated muscle decreases motoneurone survival activity in extracts of these muscles. The result suggests that motoneurone survival is dependent on a factor(s) in muscle whose synthesis and/or release is regulated by muscle contraction.