Consider the apostasies of the Republican nominee-in-waiting:

Ryan has made his career out of proposing dramatic reforms to Medicare and Medicaid, arguing that they must either be partially privatized or block-granted to the states to save them for future generations. Trump has shot down these ideas in language that could be taken straight from the lips of Nancy Pelosi.

Ryan and McConnell have both been championing free-trade policies for years and criticized President Obama for dawdling on striking international-trade deals early in his term. Trump’s opposition to pretty much every trade accord of the last 25 years is now a centerpiece of his economic platform. His nomination may be the death knell for the Trans-Pacific Partnership, for which both Ryan and McConnell have long advocated.

Ryan has been a leader in the camp of congressional Republicans that has pushed for comprehensive immigration reform, including a path to legal status—if not citizenship—for undocumented immigrants. McConnell is more hawkish on immigration, but like Ryan he is adamantly opposed to Trump’s call to deport millions of people or ban Muslims from entering the United States.

On foreign policy, the two Republican leaders have been staunch internationalists; they strongly supported the Iraq War and have argued in favor of U.S.-led interventions during both the Bush and Obama administrations. Trump has said that he, like Obama, opposed the Iraq War from the start. He slammed President George W. Bush for allowing the 9/11 terrorist attacks to occur on his watch. And he recently called for an “America First” foreign policy under which the United States would threaten to withdraw support from NATO if its allies did not pay for their own defense.

Trump is not at odds with conservative doctrine on every issue. He wants to repeal Obamacare and replace it with more market-centered reforms. While he has campaigned as a populist, his tax plan skews toward the wealthy and is similar in structure to what Republicans have long proposed. And some Republicans argue that because he has shown so little interest in policy specifics and prides himself on being a non-ideological dealmaker, he would be a willing partner to congressional Republicans who could deliver him legislative victories. Ryan in particular has pushed the House GOP to develop a substantive policy agenda that would be neatly packaged for the party’s presidential nominee to pick up and campaign on in the fall. Trump, however, has thus far shown little interest in taking his cues from Capitol Hill.

Beyond all of this, conservatives must face an even scarier possible conclusion about Trump’s success. What if the conservative platform that congressional leaders like Ryan and McConnell have long advocated was never all that popular with rank-and-file Republicans? Conservative lawmakers in Congress have assumed that however much Democrats demonize Republicans for trying to slash spending and entitlement programs, cut taxes, and pursue free-trade policies, at least that agenda unified and excited the conservative base. Trump’s nomination, however, seems to blow up that claim.