H. pylori induces expansion of a KLF5 + , Lrig1 + cell population in vivo . (A) Flow cytometry dot plots demonstrate Lrig1 and KLF5 immunostaining in representative gastric epithelial cells from uninfected and H. pylori -infected mice at 4 and 8 weeks. The percentage of Lrig1 + , KLF5 + cells was quantified in uninfected and H. pylori -infected mice at 4 weeks (B) and 8 weeks (C). Each data point represents gastric epithelial cells analyzed from a single animal and mean values are shown. Circles designate uninfected mice, and squares represent H. pylori -infected mice. Mann-Whitney and ANOVA tests were used to determine statistical significance between groups.