Regarding aprepitant all are true execpt:
Aprepitant is a highly selective NK1 receptor antagonist orally active and enter the brain. It is used in treating and preventing chemotherapy induced emesis. It is metabolized by CYP3A4 enzymes and can also inhibit the metabolism of drugs metabolized by this enzyme e.g.warfarin.(Katzung 11/e p 1086,Goodman and Gilman 11/ep650)
Agonist at NK1 receptors
Crosses blood brain barrier
Ameliorate nausea and vomiting induced by chemotherapy
Metabolized by CYP450 enzymes
Gastrointestinal tract