Mechanism of action of protease inhibitors is:
Ans. (A) Prevents maturation of new viral particles(Ref: KDT 7/e p809)Function of protease enzyme in HIV is to break inactive polyproteins to functional components. This post-translational modification is required for maturation of new viral particles. Protease inhibitors like atazanavir inhibit this step.
Prevents maturation of new viral particles
Prevents translation of viral RNA
Causes apoptosis of the affected cells
Inhibits proviral RNA synthesis
Chemotherapy: General Principles