Increased alanine during prolonged fasting represents:
Ans. A. Increased breakdown of muscle proteinsDuring prolonged fasting, there is increased gluconeogenesis. Alanine provided by muscle is one of the substrates for gluconeogenesis.This is called Glucose Alanine Cycle or Cahill Cycle.So plasma level of Alanine rises in prolonged starvation.Remember:In prolonged fasting plasma level of Alanine rises.In hyperammonemia plasma level of Glutamine rises.
Increased breakdown of muscle proteins
Impaired renal function
Decreased utilization of amino acid from Gluconeogenesis
Leakage of amino acids from cells due to plasma membrane damage
Proteins and Amino Acids