Oxygen-hemoglobin dissociation curve shifted to Right side in all EXCEPT
(Alkalosis) (667 - Ganong 22nd) (611- Ganong 23rd)* Alkalosis - (Decrease in H1 concentration and increase in pH) shift oxygen dissociation curve left sideRight sided shift of oxygen- hemoglobin dissociation curve1. Increased CO2 concentration2. Increased temperature (Hyperthermia)3. Increase 2-3 DPG is a by product in EMP pathway of carbohydrates metabolism. It is present in RBC, in condition like muscular exercise and in high altitude, the DPG increased in RBC, so the oxygen - hemoglobin dissociation curve shifts to right to a great extent4. Decrease in partial pressure of oxygen5. Increase in hydrogen ion concentration and decrease in pH (Acidosis)6. In Anemia, curve shifted to right sideLeft sided shift of oxygen - hemoglobin dissociation curve1. In fetal blood** because fetal hemoglobin has got more affinity for oxygen than the adult hemoglobin.2. Decrease in H+ concentration and increase in pH (Alkalosis)3. Hypothermia4. Blood transfusion - In stored blood*, the 2, 3, DPG levels falls and the ability of this to release O2 to the tissue is reduced, this leads to curve shifted to left side
Fresh blood transfusion
Anemia
Acidosis
Alkalosis
Respiratory System