Deficiency of which of the following enzyme leads to toxicity of 5-fluorouracil?
5-fluorouracil is acted upon by dihydropyrimidine dehydrogenase - Deficiency - accumulation of 5-FU - toxicity.
Purine nucleoside phosphorylase
Dihydropyrimidine dehydrogenase
PRPP synthase
Adenosine deaminase
Nucleotides