Substance (s) freely filtered across glomerular capillaries : (PGI Nov 2009)
Ans: A (Glucose) Filtereability of SolutesFilterability of solutes is inversely related to their size. Substance are freely filtered by glomerulus as water when filterability is of 1.0QIf the size of molecules approaches to that of albumin, filterability decreases approaching zeroSome low molecular wt. substance e.g. calcium and fatty acids are not freely filtered.Na. Inulin & glucose are freely filteredQ (filterability = 1).* Albumin, myoglobin ore not freely filteredQTable (Guyton) : Filtereability of Substances by Glomerular Capillaries Based on Molecular WeightSubstanceMolecular WeightFilterabiltiyWater181.0Sodium231.0Glucose1801.0Inulin5,5001.0Myoglobin17,0000.75Albumin69,0000.005Also RememberNegatively charged large molecules are filtered less easily than positively charged molecules of equal molecular size[Guyton 11th/ 317)
Glucose
Albumin
Thyroxin
Creatinine
Glomerular Filtration, Renal Blood Flow, and Their Control