About Transfusion-Related Acute Lung Injury (TRALI), whiat is false ?
Transfusion-Related Acute Lung Injury TRALI is among the most common cause of transfusion related fatalities. The recipient develops symptoms of hypoxia (PaO2/FiO2 < 300 mmHg) and signs of noncardiogenic pulmonary edema, including bilateral interstitial infiltrates on chest x-ray, either during or within 6 h of transfusion. Treatment issuppoive, and patients usually recover without sequelae. TRALI usually results from the transfusion of donor plasma that contains high-titer anti-HLA class II antibodies that bind recipient leukocytes. Anti-HLA class I and anti-human neutrophil antigen (HNA) antibodies can be involved as well. The leukocytes aggregate in the pulmonary vasculature and release mediators that increase capillary permeability. Testing the donor's plasma for anti-HLA antibodies can suppo this diagnosis. The implicated donors are frequently multiparous women. The transfusion of plasma and platelets from male and nulliparous women donors reduces the risk of TRALI. Recipient factors that are associated with increased risk of TRALI include smoking, chronic alcohol use, shock, liver surgery (transplantation), mechanical ventilation with >30 cm H20 pressure suppo and positive fluid balance. Ref - Harrisons 20e p814
Anti-HLA antibodies are seen
Implicated donors are frequently multiparous women
Leucocytes aggregate in the pulmonary vasculature
Develops signs of non cardiogenic pulmonary edema
Miscellaneous