Treatment of lithium Induced diabetes Insipidus -
Ans is option 3- amiloride Amiloride is currently the treatment of choice for polyuria in lithium induced diabetic insipidus. Amiloride a potassium sparing diuretic is the drug and raise maximum urinary osmolality in lithium treated patients. It blocks the cellular uptake of lithium ENaC. Thus antogonizing the inhibitory effects of lithium on Vasopressin induced water transpo. Ref Harrison 19 /304
Vasopressin
Mineralocoicoid antagonist
Amiloride
Loop diuretic
Endocrinology