True about pKa is:-
* pKa is the pH at which ionized fraction(50%) of drug equals to unionized fraction(50%). * i.e. 50% is lipid soluble and 50% is water soluble. * It is the pH at which 50% of drug can cross the membrane and 50% of drug cannot cross the membrane.
pH at which ionized fraction of drug equals to unionized fraction
pH at which ionized fraction of drug is more than unionized fraction
pH at which ionized fraction of drug is less than unionized fraction
pH at which ionized fraction of drug is twice unionized fraction
Pharmacodynamics