Apoptosis activating factor 1 (Apaf-1)
Apaf-1 combines with cytoplasmic cytochrome C that leads to formation of apoptosome complex which further triggers caspase 9 activation. Thus, leading to apoptosis via intrinsic pathway.
Activates caspase 9
Activates caspase 8
Activates Bcl-1 and Mcl-1
Binds with mitochondrial cytochrome C