Submicroscopic deletions of any size can be detected by:
a. Multiplex ligation-Dependent probe amplification(Ref: Nelson's 20/e p 605, Ghai 8/e p 6045)Multiplex Ligation-Dependent Probe Amplification (MLPA): It is a technique which mixes DNA hybridization, ligation, & PCR amplification to detect deletions & duplications of any size, including anomalies that are too large to be detected by PCR and too small to be identified by FISH.
Multiplex ligation-Dependent probe amplification (MLPA)
Southern blotting
Cytogenomic array technology
Chromosome painting
Genetics And Genetic Disorders