The rationale for sucralfate therapy in peptic ulcers does not include :
A Sucralfate binds to the base of the ulcer crater and inhibits the pepsin mediated protein hydrolysis. It by itself has no acid neutra-lizing action. Other mechanisms proposed for its effect are stimulation of prostaglandin synthesis and stimulation of local epider-mal growth factor.
It has an acid neutralizing action.
It inhibits pepsin mediated protein hydrolysis.
It stimulates the production of epidermal growth factor.
It stimulates prostaglandin synthesis.