In genetic deficiency of MPO, the increased susceptibility to infection is due to:
In MPO deficiency there is decreased microbial killing because of defective MPO--H2O2 system, so there is an inability to produce hydroxyl halide radicals.
Defective production of Prostaglandins
Defective rolling of' neutrophils
Inability to produce hydroxyl halide radicals
Inability to produce hydrogen peroxide
Primary Immunodeficiency