Not a premalignant condition:
Fragile X syndrome is a genetic condition causing intellectual disability. 
It causes mild to severe intellectual disability. 
It affects both males and females, but females usually have milder symptoms.
Symptoms include delay in talking, anxiety and hyperactive behavior. Some people have seizures. 
Physical features might include large ears, a long face, a prominent jaw and forehead and flat feet.

All other options have an associated risk of malignancy.
Fragile X syndrome
Down’s syndrome
Bloom syndrome
Fanconi’s syndrome