Orotic aciduria is due to deficiency of
Orotic aciduria an autosomal recessive disorder, can be caused by a deficiency in the enzyme UMPS, a bifunctional protein that includes the enzyme activities of orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase.
Decarboxylase
Tyrosinase
Isomerase
Homogentisate oxidase
Metabolism of nucleic acids