A patient with recurrent bacterial infections is diagnosed to have a genetic deficiency in myeloper-oxidase. The cause of increased susceptibility to infections is -
Harshmohan textbook of pathology 7th edition. the mechanism of microbicidal killing is by oxidative damage by the production of reactive oxygen metabolites. NADPH Oxidase present in the cell membrane of phagosome reduced oxygen to super oxide ion. Superoxide is subsequently conveed to hydrogen peroxide. MPO acts on hydrogen peroxide in the presence of halide to form hypohalous acid. This is called hydrogen peroxide- MPO- halide system . And is more potent anti bacterial system..
Defective neutrophil degranulation
Defective production of prostaglandins
An inability to produce hydroxyhalide radicals
Decreased oxygen consumption after phagocytosis
General pathology