Initial mechanism of action of intra-tympanic gentamicin microwick catheter inseed into inner ear in treatment of Menier's disease
Ans. c. Acts on melanoreceptors of outer hair cell Intra-tympanic Gentamicin is used in Menier's Disease, it is Predominantly vestibulotoxic, and acts by destroying the dark cells (melanoreceptors) of the secretary epithelium, thus decreasing the endolymph production Intra-tympanic Gentamicin in Menier's Disease Mechanism of Action: Predominantly vestibulotoxic, and acts by destroying the dark cells (melanoreceptors) of the secretary epithelium,thus decreasing the endolymph production Gentamicin destroys the endolymph secreting dark cells before destroying the sensory vestibular epithelium This treatment has high efficacy in controlling the veigo upto 90%. Regarding Gentamicin mechanism: "The main alternative to the mechanism being destruction of dark cells is the hypothesis that there is a paial damage to the vestibular hair cells. Recent studies in animals suggest that the type-I hair cells are the most sensitive, and the type-II hair cells are more resiliant."
Damage outer hair cell
Binds to hair cell Na*-K+ ATPase channel
Acts on melanoreceptors of outer hair cell
Bind to Mg" channel