What is the cause of hypercoagulation in nephrotic syndrome:
Thrombotic and thromboembolic complications are common in nephrotic syndrome due to loss of anticoagulant factor (e.g. antithrombin III, protein C and S) combined with increased platelet activation. Renal vein thrombosis is most often a consequence of this hypercoagulative state. There is also increased synthesis of fibrinogen in the liver.
Loss of antithrombin III (AT III)
Decreased fibrinogen
Decreased metabolism of vitamin K
Increase in Protein C
Nephrotic Syndrome