All are true about sitagliptin EXCEPT:
ANSWER: (A) Always given with insulinREF: Harrison's 18th ed ch: 344Dipeptidyl peptidase IV inhibitors:Saxagliptin, Sitagliptin, VildagliptinDPP-IV inhibitors inhibit degradation of native GLP-1 and thus enhance the incretin effect. DPP-IV, which is widely expressed on the cell surface of endothelial cells and some lymphocytes, degrades a wide range of peptides (not GLP-1 specific).DPP-IV inhibitors promote insulin secretion in the absence of hypoglycemia or weight gain, and appear to have a preferential effect on postprandial blood glucose.DPP-IV inhibitors are used either alone or in combination with other oral agents in adults with type 2 DM.Reduced doses should be given to patients with renal insufficiency. These agents have relatively few side effects.Reduction in HbA1 C: 0.5-0.8 %Do not cause hypoglycaemiaReduce dose with renal diseaseThe DPP-4 enzyme is known to be involved in the suppression of certain malignancies, particularly in limiting the tissue invasion of these tumours.
Always given with insulin
Preferentially reduce post prandial blood sugar
Less side effects
Lowers HbA1 C
Endocrinology