Local lymph nodules are enlarged near the infected wound. Increased amount of macrophages, lymphocytes, lymphatic follicles in the coical layer and large amount of plasma cells were revealed on histological examination. What process in the lymphatic nodules represent these histological changes?
In the given question there is enlargement of local lymph nodes near the infected wound. Histologically:- Presence of Macrophages, Lymphocytes, Lymphatic follicles in the coical layer and large amount of Plasma cells. It is because the antigens from the wound are going to be drained to the lymph node. These antigens will cause B cell activation, once the B cell are going to be activated, they are going to get conveed into the Plasma cell and that is responsible for causing enlargement of the lymph node. Therefore, after any kind of infection or any kind of inflammation the reactive lymph node enlargement will occur and this is explained on the basis of Antigen stimulation.
Antigen stimulation
Acquired insufficiency of the lymphoid tissue
Tumour transformation
Innate insufficiency of the lymphoid tissue
Basic Concepts