A middle aged old man, with chronic renal failure is diagnosed to have sputum-positive pulmonary tuberculosis. His creatinine clearance is 25ml/min. All of the following drugs need modification in doses except:
Ans. is 'c' i.e. Rifampicin This question has been repeated several times. Its advised to go through tables in C.M.D.T. and in Harrison mentioned above in Ref.More question related to this topic.Most nephrotoxic cephalosporin - cephaloridine*Most nephrotoxic aminoglycoside - Gentamycin*Least nephrotoxic aminoglycoside - Tobramycin*Only tetracycline safe in Renal failure- Doxycycline*Least nephrotoxic antitubercular - Rifampicin*
Isoniazide
Streptomycin
Rifampicin
Ethambutol
Anti-Tuberculosis