A middle aged man with chronic renal failure is diagnosed to have sputum-positive pulmonary tuberculosis. His creatinine clearance is 25 ml/min. All of the following drugs need modification in doses except:
Ans. (C) Rifampicin(Ref: Katzung 11/e p826, KDT 8th/e p818)Rifampicin is secreted in bile, so it does not require dose adjustment in renal failure
Isoniazid
Streptomycin
Rifampicin
Ethambutol
Chemotherapy: General Principles