A 30-year-old man who was recently staed on haloperidol 30mg/day developed hyperpyrexia, muscle rigidity, akinesia, mutism, sweating, tachycardia and increased blood pressure. The investigations showed increased WBC count, increased creatinine phosphokinase. There is no history of any other drug intake or any sign of infection. The most likely diagnosis
Neuroleptic Malignant Syndrome (Fever, EPS, High CPK, catatonic symptoms and autonomic dysfunction) Maximum with probably haloperidol (antipsychotic) Management: Bromocriptine, Dantrolene, Baclofen, General suppoive care. Add-on lorazepam, Occasionally ECT Ref: A Sho Textbook of Psychiatry, Niraj Ahuja, 7th Edition, pg. no. 179
Drug overdose
Neuroleptic malignant syndrome
Drug induce Parkinsonism
Tardive dyskinesia
Pharmacotherapy in psychiatry