Most hereditary ovarian cancers result from germline mutations in the
Most hereditary ovarian cancers result from germline mutations in the BRCA1 and BRCA2 genes. The mutations are inherited in an autosomal dominant fashion, and therefore a full pedigree analysis (i.e., both maternal and paternal sides of the family history for both breast and ovarian cancer) must be carefully evaluated in all patients with epithelial ovarian cancer, and those withfallopian tube cancer and peritoneal cancer
BRCA1 and BRCA2
MSH2
PMS1
MLH1
Gynaecological oncology