What is the mechanism of action of Fluconazole?
Ref. KDT. Page. 793
Fluconazole

They inhibit the fungal cytochrome P450 enzyme ‘lanosterol 14-demethylase’ and thus impair ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus.
lower affinity for mammalian CYP450 enzymes and lesser propensity to inhibit mammalian sterol synthesis – causes less side effects
It is a water-soluble triazole having a wider range of activity
Indications include cryptococcal meningitis, systemic and mucosal candidiasis in both normal and immunocompromised patients, coccidioidal meningitis and histoplasmosis
Inhibits fungal mitosis
Inhibits lanosterol 14 demethylase
Inhibits squalene epoxidase
Inhibit ß1,3 glucan synthase