All are true about acetaminophen except:
At therapeutic doses, about 95% of acetaminophen undergoes detoxification in the liver by phase II enzymes and is excreted in the urine as glucuronate or sulfate conjugates The injury produced by NAPQI (N-acetyl-benzoquinoneimine) involves two mechanisms: Covalent binding to hepatic proteins-Damage to cellular membranes and mitochondrial dysfunction, Depletion of glutathione, making hepatocytes more susceptible to reactive oxygen species-induced injury
It is the most commonly used analgesic
About 95% of acetaminophen undergoes detoxification by CYP2E1
In severe doses liver failure may occur
Injury to liver is produced by NAPQI
Cirrhosis