The term MHC restriction refers to which of the following statements?
MHC class I- or class II-restriction means that T cells recognize antigen peptide fragments only when they are presented in the antigen-recognition site of a class I (for CD8+ T cells) or class II MHC molecule(for CD4+ T cells), respectively.
Inheritance of MHC molecules
Need for antigen to be recognized in association with MHC molecules
Need for MHC genes to control complement activity
Need for MHC molecules in order to reject grafts