What is the effective antodote for acetaminophen overdose in a 28 year old suicidal patient?
N-acetylcysteine is used as an effective antidote for acetaminophen overdose. In acetaminophen overdose, N-acetylcysteine, a sulfhydryl-containing acetaminophen-specific antidote, replenishes hepatic stores of glutathione by acting as a glutathione surrogate, combining directly with reactive acetaminophen metabolites and preventing hepatic damage. N-acetylcysteine should be initiated within 10 hours of actaminophen overdose to achieve optimum results.
N-Acetyl cysteine
N-Glycolamine
Penicillamine
Fomipezole