Eirenz limits HIV infection by:
Eirenz is a NNI which acts as an allosteric (non-competitive) inhibitor of HIV reverse transcriptase. It is more potent than zidovudine on HIV-1, but do not inhibit HIV-2. If used alone, viral resistance develops rapidly by point mutation of the enzyme; therefore it should always be combined with 2 other effective drugs. S/E of Eirenz : Headache, rashes, dizziness, insomnia, neuro-psychiatric symptoms
Binding to active site of HIV reverse transcriptase
Impairing the binding of HIV virion to CD4 receptors on T- cells
Inhibiting the HIV protease
Serving as an allosteric inhibitor of HIV reverse transcriptase
Anti-HIV Drugs