Which of the following is not a property of propofol?
Ans is 'b' i.e. Anticonvulsant effect * It does not possess anticonvulsive action (unlike thiopentone), rather sometimes it can produce muscle twitching & myoclonusPropofol properties* Propolol is the most frequently used intravenous anaesthetic today.* It can be used for both induction as well as maintenance.* Like thiopentone it is cerebroprotective - Reduce ICT, cerebral metabolism, oxygen consumption and cerebral perfusion.* Like thiopentone it also decreases intraocular pressure.* It causes fall in BP and bradycardia.* Like thiopental it does not possess muscle relaxant action.* Propofol possess significant antiemetic and antipruritic action* Propofol decreases polymorphonuclear leukocyte chemotoxis but not aherence, phagocytosis and killing (Thiopentone blocks all these) - Increased life threatening infections.* Because the required decrease in concentration for awakening after anesthesia or sedation with propofol is generally less than 50%, recovery from propofol remains rapid even after prolonged infusion.* Propofol is particularly suitable for outpatient surgery (day care surgery) as residual impairment is less marked and shorter acting.* Intermittent injection or continuous infusion of propofol is frequently used for total i.v. anaesthesia (TIVA) when supplemented by fentanyl.* Propofol causes dose dependent myocardial depression.* It is anaesthetic of choice for intubation in ICU and for patients with malignant hyperthermia.* It is metabolized in liver, but significant extrahepatic metabolism also occur in lungs, and excreted via kidney.* Side effects - pain on injection, myoclonus, apnea, | BP and rarely thrombophlebitis.
Pain on injection
Anticonvulsant effect
Increase chances of infection
No muscle relaxant property
General Anesthesia