Which drug abolishes coicomedullary osmotic gradient ?
Ans. is'a'i.e., Furosemide (Ref. KDT p. 579)Furosemide (Frusemide)It is a high ceiling (loop) diuretic which inhibits of Na+-K+-2cl- cotranspoer.The coicomedullary osmotic gradient is abolished and positive as well as negative free water clearance is blocked.K+ excretion is increased mainly due to high Na+ load reaching DT.
Furosemide
Thiazide
Spironolactone
Triamterene