Which among the following extra intestinal manifestations of IBD correlate with bowel disease activity?
Extra intestinal manifestations of IBD: The most commonly extraintestinal manifestations of IBD involve the skin, joints, eyes, and liver in up to one-third of patients. Extraintestinal manifestations of IBD:Nonintestinal manifestations are similar for both CD and UC. Dermatologic manifestationsinclude the relatively common erythema nodosum that often correlate with acute flares. The more problematic pyoderma gangrenosum is much more common in UC than CD, and its course is independent of IBD activity. Joint manifestationsinclude peripheral ahritis that correlates with exacerbations of bowel disease, and central ahritis (ankylosing spondylitis or sacroiliitis) that does not correlate with bowel activity. Ocular complicationsinclude conjunctivitis, episcleritis, and uveitis and may occur independent of bowel activity. Hepatobiliary complicationsinclude nonalcoholic fatty liver disease, cholestasis, gallstones (CD>UC, paicularly with ileal disease due to decreased bile acid reabsorption), and primary sclerosing cholangitis (UC>>CD), a fibrotic disorder of intra- and extrahepatic bile ducts that does not correlate with bowel disease activity. Renal complicationsinclude kidney stones that are more common in CD than in UC. Oxalate absorption is increased in bowel inflammation leading to calcium oxalate stones. Uric acid stones also occur with increased frequency in CD.
Pyoderma gangrenosum
Erythema Nodosum
Peripheral ahritis
Primary sclerosing cholangitis
Inflammatory Bowel Disease