Which of the following regarding sickle cell disease is false?
In HbS, the nonpolar amino acid valine has replaced the polar surface residue Glu6 of the β subunit, generating a hydrophobic “sticky patch” on the surface of the β subunit of both oxyHbS and deoxyHbS.
Ref: Harper’s illustrated biochemistry. 30th edition page no: 56
Single nucleotide change results in change of Glutamine to Valine
Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue
HbS provides resistance against malaria
Binding of deoxyHbA terminates fiber polymerization