Mechanism of action colchicine in acute gout
* Gout is a hereditary disorder with increase in serum uric acid due to increased production, or decreased excretion of uric acid and uric salt. * Thought to be caused by lack of an enzyme needed to completely metabolise purines for renal excretion. REF : HARRISONS 21ST ED
Uric acid nephrolithiasis.
Deficiency of enzyme Xanthine oxidase
Increase in serum urate concentration
Renal disease involving interstitial tissues
All India exam