Actions of GLP are all except:
C i.e. Increases gastric emptyingExplanation:The Main Actions of GLP-1 are:Stimulate insulin secretion (i.e., to act as an incretin hormone). Limits postprandialInhibit glucagon secretion. glucose excursionsInhibits gastrointestinal motility and secretion.Thus, acts as an "enterogastrone" and a part of the "ileal brake" mechanism.(GLP-1 decreases gastrointestinal motility via direct inhibitory effects on muscle and also inhibits postprandial acid secretion).GLP-1 also appears to be a physiological regulator of appetite and food intake.It induces satiety, reduces food intake hence leading to reduced weight gain.Recent discovery: (b) is able to promote p-cell mass expansion.Hence, the correct option would be option (c).The properties of GLP-1 described above, including glucose-dependent stimulation of insulin secretion and expansion of [3-cell mass, coupled with the inhibition of glucagon secretion and food intake, suggest that it would greatly complement current [3-cell therapies.Also Note:Synthesis of GLP:Formed in L cells of lower GIT.Secreted as Preproglucagon.Human preproglucagon: Found in pancreatic A cells, in L cells in the lower gastrointestinal tract and brain.It is the product of a single mRNA, but it is processed differently in different tissues.Pancreatic A cells: Processed to glucagon, major proglucagon fragment (MPGF) and residual glicentin-related polypeptide (GRPP).Intestinal L cells: Processed to glicentin, glucagon-like polypeptides 1 and 2 (GLP-1 and GLP-2), residual glicentin-related polypeptide (GRPP) and some oxyntomodulin is also formed.Levels of GLP rise after food intake. Principally sugars and fats release GLP.
Increases insulin release
Decreases glucagon release
Increases gastric emptying
Reduces appetite
Endocrinology and Reproduction