Carcinoma pancreas commonly presents with:
(Jaundice): Ref: 1128-29-LB, 537-H (1149-B&L 25th)CARCINOMA OF PANCREAS - Ductal adeno carcinomaClinical features: -* Jaundice is the most common sign and symptoms (85% patients with painless jaundice with nausea and epigastric discomfort) (1128-LB)* Jaundice due biliary obstruction is found in > 80% of patients having tumours in the pancreatic head and is typically accompanied by dark urine, a claylike appearance of stool, and pruritis (537-H)* Pain and weightless are present in > 75% patientsCourvosier's Law: - It states that in a case of obstructive jaundice if gall bladder is palpable the jaundice is not due to stone in the CBD. This in carcinoma of the head of the pancreas the gall bladder is distended with bile due to obstruction of the CBD.FrequentInfrequent* Abdominal pain* Glucose intolerance* Weight loss* Palpable gall bladder (courvosier s sign)* Jaundice* Migratory thrombophlebitis (Trousseau's sign) * GI haemarrhage * Splenomegaly* Liver nodule indicative of metastases can sometimes be felt, metastatic subumbilical ("Sister Marry Joseph node") and pelvic peritoneal ("Blummer's shelf') deposits as wel as left supraclavicular lymphadenopathy ("Virchow nodes") indicates the presence of distant metastasis, Malignant ascites, caused by peritoneal carcinomatosis may also present, with portal splenic or superior mesenteric vein occlusion, mesenteric venous pressures may be increased and collateral channels including gastroesophageal varices and a caput medusase (1669-SB)
Jaundice
Anorexia
Vomiting
Weight loss
Pancreas