Which of the following drug is associated with highest cardiac moality?
Rofecoxib is a selective COX-2 inhibitor that was withdrawn due to increased risk of MI. ARBs (losaan) and b blockers (metoprolol) are cardioprotective in CHF. These decrease the moality. Nicorandil is a K+ channel opener used in angina. It is cardioprotective by causing ischemic pre-conditioning.
Rofecoxib
Nicorandil
Losaan
Metoprolol
CHF, Angina Pectoris and Myocardial Infarction