Pentostatin acts by inhibiting:
* Pentostatin and cilastatin are not statins i.e. these do not act by inhibiting HMG-CoA reductase. * Pentostatin acts by inhibiting adenosine deaminase. * It is used for the treatment of hairy cell leukemia. * Drug of choice for hairy cell leukemia is cladribine.
RNA dependent DNA polymerase
Aldolase
Adenosine deaminase
Adenylyl cyclase
Cytotoxic Anticancer Drugs