Which one of the following compounds increases the synthesis of tumor necrosis factor, leading to activation of phagocytosis in patients with chronic granulomatous disease?
Interferon-gamma 1b (recombinant form) is used in chronic granulomatous disease to decrease infection liability because it increases the formation of tumor necrosis factor (TNF).Infliximab is a monoclonal antibody to TNF used in rheumatoid arthritis, and its use may lead to an increased infection rate. Aldesleukin is a recombinant form of IL-2.
Aldesleukin
Cyclosporine
Interferon-gamma
Infliximab
Anti-Cancer