Sparfloxacin and astemizole can cause:
Ans. (A) Ventricular arrhythmia(Ref: KDT 8/e p764)Both sparfloxacin and astemizole blocks cardiac K+ channels in high concentration. This property may result in torsades de pointes (polymorphic ventricular tachycardia).Other drugs causing torsades de pointes are:TerfenadineCisaprideZiprasidoneGrepafloxacin
Ventricular arrhythmia
Myopathy
Electrolyte imbalance
Nephropathy
Chemotherapy: General Principles