Concomitant use of valproic acid and lamotrigine increases the risk of :
Stevens-Johnson syndrome Concomitant use of valproic acid and lamotrigine increases the plasma level of lamotrigine and increases the risk of Stevens-Johnson syndrome; hence, lamotrigine should be staed as a low dose with gradual escalation.
Chondrodysplasia punctata
Paroxysmal Nocturnal hemoglobinuria
Stevens-Johnson syndrome
Floppy infant syndrome