Which of the following is most effective for gluconeogenesis:
Acetyl CoA can never be conveed to glucose but acetyl CoA activates the first step of gluconeogenesis (pyruvate carboxylase). When OAA is used for gluconeogenesis in fasting state, then acetyl CoA is not used up in TCA. So acetyl CoA accumulates. acetyl CoA - allosteric activator of pyruvate carboxylase. This reaction is anaplerotic reaction (replenish TCA intermediate OAA). Option 4- Activation of Acetyl CoA carboxylase by Citrate leads to increased fatty acid synthesis and not gluconeogenesis. Option 1- Fructose 2,6 bisphosphate inhibits fructose 1,6 Bisphosphatase (an enzyme of gluconeogenesis) hence decrease gluconeogenesis.
Fructose 2,6 bisphosphate inhibits fructose 1,6 Bisphosphatase
Acetyl CoA activates Pyruvate carboxylase
Acetyl CoA inhibits Pyruvate carboxylase
Citrate activates Acetyl CoA carboxylase
Gluconeogenesis