Which type of amyloidosis is caused by mutations in transthyretin gene?
Transthyretin (TTR) is a normal serum protein that binds and transpos thyroxine and retinol. Several distinct mutant forms of TTR (and its fragments) are deposited in a group of genetically determined disorders referred to as familial amyloid polyneuropathies. Normal TTR is also deposited (Due to overproduction) in the hea of aged individuals (senile systemic amyloidosis).
Familial Mediterranean fever
Familial amyloidosis polyneuropathy
Dialysis associated amyloidosis
Prion protein associated amyloidosis
Amyloidosis