All of the following are pattern recognition receptors for extracellular/ingested microbes, except:
Pattern recognition receptors Cells that paicipate in innate immunity are capable of recognizing ceain components that are shared among related microbes. Pattern recognition receptors are located in all cellular compaments where microbes may be present: plasma membrane receptors detect extracellular microbes, eg. Toll-like receptors (TLRs), C-type lectin receptors (CLRs). endosomal receptors detect ingested microbes, eg. Toll-like receptors (TLRs) cytosolic receptors detect microbes in the cytoplasm, eg. NOD-like receptors (NLRs), RIG-like receptors (RLRs) Killer-cell immunoglobulin-like receptors (KIRs), are present on plasma membrane of NK cells. KIR receptors can recognise major histocompatibility (MHC) class I variants, which allows NK cells to detect virally infected cells or transformed cells.
Toll-like receptors (TLRs)
Killer-cell immunoglobulin receptors (KIRs)
NOD-like receptors (NLRs)
C-type lectin receptors (CLRs)
Basic Concepts