With reference to the optimal management of patients with sepsis in the intensive care unit, all of the following interventions are evidence-based except-
Low tidal volume during assisted ventilation prevents acute lung injury
For outcome of goal-oriented management of sepsis patients, monitoring of central venous pressure, hourly urine output and blood pressure is adequate
Intensive blood glucose monitoring and prevention of hyperglycemia improves survival in critically ill patients
The use of drotrecogin- is restricted to severely ill patients with APACHE score 25