A 15-year-old girl c/o failure to attain menarche. Her height is 4 feet. She has not yet developed secondary sexual characteristics. If USG shows uterus and vagina. FSH and LH levels are high. What is the best step in confirming the diagnosis?
Ans. is b, i.e. Perform a karyotype1st step in primary amenorrhea is to identify the site of lesion by doing Hormonal profileIn question : LH and FSH are highUSG: shows uterus and vagina are presentPt has short height (4 feet)No secondary sexual characteristicsNow since LH and FSH are high and estrogen is low (as secondary sexual characteristics are absent)[?] It is a case of hypergonadotropic hypogonadism --so most probably it is Turners syndrome. This can be confirmed by doing karyotyping.Always remember in Primary amenorrhea1st Test: Hormonal ProfileBest Test: Karyotyping
Perform a CT
Perform a Karyotype
Perform a buccal smear
Perform progesterone withdrawal test
Disorders in Menstruation