All are true about blood coagulation except?
• Ataxia telangiectasiais an autosomal recessive condition.
• Patients have increased sensitivity to x-ray-induced chromosome abnormalities.
• Characterized by an ataxic-dyskinetic syndrome beginning in early childhood, caused by neuronal degeneration predominantly in the cerebellum, the subsequent development of telangiectasias in the conjunctiva and skin, and immunodeficiency.
• The nuclei of cells in many organs (e.g., Schwann cells in dorsal root ganglia and peripheral nerves, endothelial cells as well as pituicytes) show a bizarre enlargement of the cell nucleus and are referred to as amphicytes.
• The lymph nodes, thymus, and gonads are hypoplastic.
• Clinical features include recurrent sinopulmonary infections and unsteadiness in walking.
• Increased risk of development of lymphoid malignant disease (T-cell leukemia and lymphoma)
All other options are autosomal dominant conditions.
Intrinsic pathway can be activated in vitro.
Extrinsic pathway is activated by contact of plasma with negatively charged surfaces.
Calcium is very important for coagulation.
Factor X is a part of both intrinsic and extrinsic pathway.