The most impoant advese effect of sotalol is?
Ans. is 'a' i.e., Torsades de pointes Sotalol It is a nonselective -blocker. It prolongs the action potential (class 3 antiarrhythmic). Sotalol is well absorbed orally with bioavailibility of 100%. It is not metabolized in liver. Excretion is predominantly by kidney in the unchanged form. The most significant cardiac adverse effect is dose related torsade de points. (Polymorphic ventricualr tachycardia).
Torsades de pointes
Hea block
Pulmonary fibrosis
Vomiting