Patients with mutations leading to defective beta-oxidation of fatty acid usually have hypoglycemia because of
Acetyl-coenzyme A or acetyl-CoA is an impoant molecule that paicipates in many biochemical reactions in protein, carbohydrate, and lipid metabolism. Its main function is to deliver the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production. Ref-Sathyanarayana 4/e p399
Less ATP for gluconeogenesis
Less acetyl CoA for glucose formation
Increased fatty acids decrease glucose utilization
Fatty acids inhibit transpo of glucose for metabolism
Metabolism of nucleic acids