True regarding HCC
Hepato cellular carcinoma Most common primary liver malignancy is HCC HCC represents most common solid organ cancers HCC : most common cause of death in patients with cirrhosis More prevalent in Asia and subsaharan Africa ( high frequency of chronic infection with HBV and HCV) 100 fold increase in risk in individuals with HBV infection More common in males, 60-90% arise in cirrhotic liver Post necrotic cirrhosis has highest risk of developing into HCC Alcoholic cirrhosis and primary biliary cirrhosis has lower risk Strong propensity for invasion of vascular channels Ref: Sabiston 20th edition Pgno :1458
Non- Alcoholic steatohepatitis is a risk factor
OCP's are a cause
Focal nodular hyperplasia may turn malignant
Chromosomal abnormalities are common
G.I.T