What does MHC class III genes encode?
MHC class III genes encodes proteins of classic and alternate complement pathways (C2 and C4, properdin factor B), soluble proteins, tumor necrosis factors (TNF alpha, beta), HSP 70 and the 21 hydroxylase producing gene. Genes coding for Class III MHC molecules are located in the class III region on chromosome 6, between HLA B locus and the HLA DR. The class III molecules are not histocompatibility antigens but are ceain soluble molecules such as complement components and tissue necrosis factor. Ref: Textbook of Immunology By Basir, Pages 93-4.
Interleukin 2
Beta 2 microglobulin
Tumor necrosis factor
Complement component C3