Renal biopsy demonstrates concentric, laminated thickening of aeriolar walls due to proliferation of smooth muscle cells. This process is BEST described by which of the following terms?
The "onion skinning" morphology of these aerioles is a feature of hyperplastic aeriolosclerosis. Affected vessels may also show necrotizing aeriolitis with acute vessel wall necrosis accompanied by fibrin deposition. This type of vessel change is a hallmark of severe (malignant) hypeension, and can damage aerioles throughout the body, notably in the kidneys, intestine, and gall bladder.Atherosclerosis would produce luminal narrowing by plaques.Hyaline aeriolosclerosis would produce paial replacement of aerial walls by homogeneous, pink material.Monckeberg's aeriosclerosis is characterized by medial calcification of smaller aeries. Ref: Chandrasoma P., Taylor C.R. (1998). Chapter 20. The Blood Vessels. In P. Chandrasoma, C.R. Taylor (Eds), Concise Pathology, 3e.
Atherosclerosis
Hyaline aeriolosclerosis
Hyperplastic aeriolosclerosis
Monckeberg's aeriosclerosis