Which antihypeensive is a prodrug and is conveed to its active form in brain?
Both methyldopa and minoxidil are prodrugs. Conversion of methyl dopa to a-methylnorepinephrine takes palce in the brain. Minoxidil is activated to minoxidil sulphate (by phase II reaction) in the periphery.
Clonidine
Methyl dopa
Minoxidil
Nitroprusside
Hypeension, Arrhythmias, Dyslipidemia