A 63 year old man presents with splenomgaly and lymphadenopathy. Immunophenotype was positive for CD 19, CD79b and FMC7. The most likely diagnosis is:
Answer is B (Mantle cell Lymphoma) Coexpression of the B lymphocyte lineage marker CD 19 and T lymphocyte marker CD5 is unique to CLL and mantle cell Lymphoma. CLL can be differentiated from MCL be expression of CD79b and FMC-7 both of which are absent in CLL and positive in 11CL- Handbook of clinical immunology 2nd/245 `CU can be differentiated from MCL by expression of CD79b and FMC-7 both of which are absent in CLL/SLL and bright in MCL' -Handbook of human Immunology 2"d/245
Hairy cell leukemia
Mantle cell Lymphoma (MCL)
Chronic Lymphocytic Leukemia (CLL)
Follicular Lymphoma