Activation of which of the following enzymes is responsible for acute pancreatitis?
Enzyme activated by trypsin is phospholipase A2. This enzyme splits a fatty acid off phosphatidylcholine (PC), forming lyso-PC. Lyso-PC damages cell membranes. It has been hypothesized that in Acute pancreatitis - a severe and sometimes fatal disease, phospholipase A2 is activated prematurely in the pancreatic ducts, with the formation of lyso-PC from the PC that is a normal constituent of bile. This causes disruption of pancreatic tissue and necrosis of surrounding fat.
Phospholipase A2
Colipase
Procarboxypeptidase
ProElastase
Gastrointestinal System