Long chain fatty acids penetrate the inner mitochondrial membrane as
Long-Chain Fatty Acids Penetrate the Inner Mitochondrial Membrane as Carnitine Derivatives Carnitine (-hydroxy--trimethylammonium butyrate), (CH3)3N+--CH2--CH(OH)--CH2--COO-, is widely distributed and is paicularly abundant in muscle. Long-chain acyl-CoA (or FFA) cannot penetrate the inner membrane of mitochondria. In the presence of carnitine, however, carnitine palmitoyltransferase-I, located in the outer mitochondrial membrane, conves long-chain acyl-CoA to acylcarnitine, which is able to penetrate the inner membrane and gain access to the -oxidation system of enzymes. Carnitine-acylcarnitine translocase acts as an inner membrane exchange transpoer. Acylcarnitine is transpoed in, coupled with the transpo out of one molecule of carnitine. The acylcarnitine then reacts with CoA, catalyzed by carnitine palmitoyltransferase-II, located on the inside of the inner membrane, reforming acyl-CoA in the mitochondrial matrix, and carnitine is liberated. Ref: Biochemistry by U. Satyanarayana 3rd edition Pgno : 288
Carnitine derivatives
Pyruvate
Acetyl coA derivatives
Acyl CoA
Metabolism of lipid