Non Anionic gap acidosis is seen in
(A) Diarrheoa # CAUSES OF NON-ANION GAP METABOLIC ACIDOSIS> Gastrointestinal bicarbonate loss: Diarrhea; External pancreatic or small-bowel drainage; Ureterosigmoidostomy, jejunal loop, ileal loop Drugs: Calcium chloride (acidifying agent); Magnesium sulfate (diarrhoea); Cholestyramine (bile acid diarrhea)> Renal acidosis: Hypokalaemia Proximal RTA (type 2) Distal (classic) RTA (type 1)> Hyperkalemia: Generalized distal nephron dysfunction (type 4 RTA) Mineralocorticoid deficiency Mineralocorticoid resistance inc. Na+ delivery to distal nephron Tubulointerstitial disease Ammonium excretion defect> Drug-induced hyperkalemia (with insufficiency):Potassium-sparing diuretics (amiloride, triamterene, spironolactone) Trimethoprim Pentamidine Angiotensin-converting enzyme inhibitors and AT-II receptor blockers Nonsteroidal anti-inflammatory drugs Cyclosporine> Others: Acid loads (ammonium chloride, hyperalimentation) Loss of potential bicarbonate: ketosis with ketone excretion Expansion acidosis (rapid saline administration) Hippurate, Cation exchange resins In lactic acidosis, DKA and salicylate poisoning high anionic gap metabolic acidosis is seen.
Diarrhoea
Lactic acidosis
Salicylate poisoning
Diabetic ketoacidosis
Miscellaneous