When nitrates are combined with calcium channel blockers:
Nitrates primarily decrease preload, while CCBs have a greater effect on afterload. Their concurrent use may decrease cardiac work to an extent not possible with either drug alone. This combination may be especially valuable in severe vasospastic angina. Eg for nitrates: GTN CCBs-amlo,felo,clevidipine, verapamil, diltiazem K D Tripathi: essentials of medical pharmacology; edition 6; pg no:533
Aerial pressure will decrease
Hea rate will increase
Ejection time will decrease
End-diastolic volume will increase
Cardiovascular system