Anaphylactic reaction caused by NSAIDs, all are true, except ?
Ans. is 'b' i.e., COX-2 inhibitors are safe(Ref: Clinical pharmacology 3d/e p.786)Anaphylactic reaction (anaphylaxis)It is dre to immediate (type-L) hypersensitivity involving cross linking of drug-specific IgE.Regardless of COX selectivity pattern, NSAIDs may function as haptens capable of inducing allergic sensitization.Thus, all COX inhibitors (nonselective or selective) can cause this reaction.
Caused by All NSAIDs
COX-2 inhibitors are safe
Related to hypersensitivity reaction
Not related to inhibition of COX