Characteristic feature of Goodpasture's syndrome?
In Goodpasture syndrome, type 1 RPGN & type II hypersensitivity reaction are seen. It is characterized by serum antibodies against alpha 3 NC1 domain of collagen - IV. Lumpy-bumpy deposits on immunofluorescence- seen in Post Streptococcal GN
Lumpy-bumpy deposits on immunofluorescence
Serum antibodies against alpha 3 NC 1 domain of collagen-IV
Serum antibodies against alpha 1 NC 1 domain of collagen III
Anti DNAse antibodies positive
Nephritic & Nephrotic Syndrome