Disulfiraim and acamprosate are used for:
Disulfiram inhibits the enzyme aldehyde dehydrogenase probably after conversion into active metabolite .When alcohol is ingested after taking disulfiram the concentration of acetaldehyde in tissue & blood rises & number of highly distressing symptoms produced. Disulfiram aversion therapy is indicated in abstinent subjects. Ref KD Tripathi 8th ed.
Alcohol abstinence
Cocaine abuse
Opium poisoning
Atropine over dose
Central Nervous system