Linezolid inhibits bacterial protein synthesis by :
Linezolid : Inhibits bacterial protein synthesis By acting at an early step and a site different from that of other AMAs. Binds to the 23S fraction P site of the 50S ribosome and interferes with formation of the ternary N- formylmethionine-tRNA (tRNAfMet) -70S initiation complex Binding of linezolid distos the tRNA binding site Overlapping both 50S and 30S ribosomal subunits and stops protein synthesis before it stas
Binds to the 23S fraction of the 30S ribosome at P site
Binds to the 23S fraction of the 50S ribosome at A site
Binds to the 23S fraction of the 30S ribosome at A site
Binds to the 23S fraction of the 50S ribosome at P site
Protein Synthesis Inhibitors