Mechanism of action of Aspirin in MI is :
Ans is 'a' Thromboxane A2 synthesis inhibition (Ref Goodman Gilman, 10/e, p. 1534; KDT 5/e p. 572).Aspirin is used in MI because of its antiplatelet action.Antiplatelet action of aspirin: Aspirin blocks the production of thromboxane A2 by inactivating the enzyme cyclooxygenase. Cyclooxygenase is an enzyme that produces cyclic endoperoxide precursor of thromboxane A2.
Thromboxane A2 synthesis inhibition
Thromboxane A2 synthesis stimulation
Antagonist of adenosine
Stimulation of PGF2 synthesis
Antiplatelets and Fibrinolytics