Drug ezetimibe act by?
Ezetimibe acts by inhibiting the intestinal absorption of cholesterol and phytosterols. It interferes with a specific CH transpo protein NPC1C1 in the intestinal mucosa and reduces the absorption of both dietary and biliary CH. (REF. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D TRIPATHI-6th edition.Page No-618)
Enhancing excretion of bile acids
Decreasing absorption of cholesterol
Inhibiting HMG-CoA
Inhibiting intracellular lipase
Cardiovascular system