Which of the following metabolic abnormality is seen with long term use of spironolactone?
By inhibiting H+ secretion in parallel with K+ secretion, the K+-sparing diuretics can cause acidosis similar to that seen with type IV renal tubular acidosis. Ref: Katzung, 11th edition, Chapter 15.
Metabolic acidosis
Metabolic alkalosis
Hyperkalemia
None of the above