Which of the following pigments are involved in free
Ref Robbins 7/e p39; 9/e p64 Impoant points about lipochrome or lipofuscin Lipofuscin, or "wear-and-tear pigment," is an insoluble brownish-yellow granular intracellular material that accumulates in a variety of tissues (paicularly the hea, liver, and brain) as a function of age or atrophy. Lipofuscin represents complexes of lipid and protein that derive from the free radical-catalyzed peroxidation of polyunsaturated lipids of subcellular membranes. It is not injurious to the cell but is a marker of past free radical injury. The brown pigment (Fig. 1-27), when present in large amounts, impas an appearance to the tissue that is called brown atrophy. By electron micros- copy, the pigment appears as perinuclear electron-dense granules
Lipofuscin
Melanin
Bilirubin
Hematin
General anatomy