Increased uric acid level in plasma is due to
Salvage pathway ensures the recycling of purines formed by the degradation of nucleotides.Some reactions will consume PRPP and produce more nucleotides will inhibit the enzymes thus salvage pathway is blocked.Ref: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 567
Increased purine utilization
Decreased purine synthesis
Decreased degradation purine
Decreased reutilization purine
Metabolism of protein and amino acid