In acute liver injury-
AST/ALT ratio.. Most causes of liver cell injury are associated with a greater increase in ALT than AST; however, an AST to ALT ratio of 2:1 or greater is suggestive of alcoholic liver disease, paicularly in the setting of an elevated gamma-glutamyl transferase. Ref Davidson edition23rd pg 852
AST/ALT ratio < 1 occur in most of the hepatocellular conditions
AST/ALT ratio > 2:1 suggestive of alcoholic liver disease
Synthesis ofAST is inhibite by ethanol
In alcoholic liver disease AST/ALT ratio < 1
G.I.T