Risk of breast carcinoma is most likely with which of the following conditions?
Proliferative disease with atypia includes atypical lobular hyperplasia (ALH) and atypical ductal hyperplasia (ADH). Atypical ductal/lobular hyperplasia is associated with 4-5 times relative risk of breast carcinoma compared to non-proliferative breast changes. Conditions with lesser risk for carcinoma:- Sclerosing adenosis Fibrocystic change Apocrine metaplasia Duct ectasia Also know: Nonproliferative disease consists of three major morphologic changes: cysts, fibrosis, and adenosis. It is termed "nonproliferative" because the lesions contain single layers of epithelial cells. The most common nonproliferative breast lesions are simple cysts lined by a layer of luminal cells that often undergo apocrine metaplasia Proliferative disease without atypia includes epithelial hyperplasia, sclerosing adenosis, complex sclerosing lesion, and papilloma.
Sclerosing adenosis
Atypical epithelial hyperplasia
Fibrocystic change
Apocrine metaplasia
Breast