Which of the following represent the mechanism of action of Memantine?
Memantine works as a NMDA receptor antagonist. It is used to slow the progressive decline in patients with Alzheimer disease. Other commonly used NMDA receptor antagonists are: Riluzole which is used to slow the progression of impairment and modestly improve the life expectancy of patients with amyotropic lateral sclerosis. Amantadine is used along with levodopa to improve function in patients with Parkinson disease. Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 7. Neurotransmitters & Neuromodulators. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.
GABA antagonist
Alpha 2 antagonist
5HT 2A antagonist
NMDA antagonist