Which of the following is a histological feature of Whipple's disease?
Whipple's disease Hallmark - Presence of PAS +ve, diastase resistant granules inside foamy macrophages containing rod shaped bacilli. The presence of T. Whipplei outside macrophages is more impoant indicator of active disease than their presence inside the macrophages. Multisystem involvement: Joints (Early involvement) Intestine - Impaired lymphatic drainage resulting in malabsorption & diarrhea Lymph nodes CNS (Late involvement) Rx - Antibiotics
Infiltration of histiocytes in the lamina propria
Granuloma in the lamina
Macrophages with PAS (+) material inside the lamina propria
Eosinophils in the lamina propria
Small Intestine Malabsorption disorders