A patient of abdominal sepsis was staed on empirical treatment with intravenous ampicillin and gentamicin. Regarding the treatment of this patient, which statement is most accurate
Ref-KDT 6/e p679,680 Abdominal sepsis is a mixed type of intection caused by both aerobic and anaerobic organisms. Ampicillin and gentamicin will inhibit most of the aerobic organisms but these ae not ettective against anaerobic organisms. Therefore metronidazole or clindamycin should be included in the treatment regimen.
Empirical treatment of abdominal sepsis should always include a third generation cephalosporin
A drug active against anaerobe should be included in the antibiotic regimen
Combination of ampicillin and gentamicin provides good coverage for all likely pathogens
If the patient is severely allergic to ampicillin, then ceftriaxone should be used
Other topics and Adverse effects