Mrs. X, Primigravida at 36weeks complains of generalized pruritis with increased intensity in soles. Diagnosis is
Clinical presentation of Intrahepatic Cholestasis of Pregnancy:Pruritus develops in late pregnancy, although it occasionally manifests earlier. There are no constitutional symptoms, and generalized pruritus shows a predilection for the soles. Skin changes are limited to excoriations from scratching. Biochemical tests may be abnormal at presentation, but pruritusmay precede laboratory findings by several weeks. Approximately 10 percent of women have jaundice.Ref: William&;s Obstetrics; 24th edition; Chapter 55
Intrahepatic cholestasis of pregnancy
HELLP
Viral hepatitis
Acute fatty liver of pregnancy
Medical, surgical and gynaecological illness complicating pregnancy