40-year-old immunocompromized patient presented with complaints of dysphagia. UGI scopy showed multiple ulcers in the distal esophagus. Biopsy from the esophagus showed the following. What is the diagnosis?
Ans. (b) Cytomegalovirus(Ref: Robbins 9th ed p 755)CMV causes shallower ulcerations and characteristic nuclear and cytoplasmic inclusions within capillary endothelium and stromal cells. Infected cells are strikingly enlarged, often to a diameter of 40 m, and show cellular and nuclear pleomorphism. Prominent intranuclear basophilic inclusions spanning half the nuclear diameter are usually set off from the nuclear membrane by a clear halo
Candida
Cytomegalovirus
Herpes
Eosinophilic esophagitis
G.I.T.