In a patient with nephrotic syndrome and hypoalbuminemia, protein binding of which drug will not be affected:
- In the given options, only Morphine has less plasma protein binding (35%), whereas all others are highly plasma protein bound (>90%).
- In nephrotic syndrome, there will be protein loss resulting in hypoalbuminemia. So less plasma proteins.
Tolbutamide
Morphine
Diazepam
Valproate