Awakening from a single bolus dose in rapid from Propofol due to;-
It is redistributed from the brain to tissues which are less perfused like muscles, resulting in rapid recovery within 20 minutes. All intravenous anaesthetic agent undergo rapid redistribution. Thus awakening from Thiopentone, Propofal, Etomidate, ketamine is very fast.
Redistribution
Excretion
Biotransformation
D- Methylation
Intravenous Anesthetic Agents