True for Vi polysaccharide vaccine
Vi polysaccharide vaccine can be given with other vaccines like Hepatitis B & Yellow fever. Option 1, 2, 3, 4 -Typhim Vi is a subunit vaccine containing the cell surface Vi polysaccharide extracted from Salmonella enterica serovar Typhi, S. typhi Ty2 strain. -Typhim Vi vaccine is indicated for active immunization against typhoid fever for persons two years of age or older. -The antibody response may be inadequate in children under 2 years of age. - Dose for adults and children is a single injection of 0.5 mL given intramuscularly in the deltoid. - Reimmunization every two years under conditions of repeated or continued exposure to the S typhi organism is recommended at this time. - Typhim Vi vaccine has efficacy against typhoid fever caused by S.typhi infection only. =The adverse reactions are predominately minor and transient local reactions:- -Local reactions such as injection site pain, erythema and induration almost always resolve within 48 hours of vaccination. -Though the antibody response in immunodeficiency states are often suboptimal, it should be given in HIV patients. -TYPHIm Vi may be administered during the same vaccination session with other common vaccines (yellow fever, diphtheria, tetanus, poliomyelitis, rabies prepared on Vero cells, meningitis A+C, hepatitis A and hepatitis B.) -Other vaccines for prophylaxis against enteric fever are:- Mono/di/trivalent heat- killed phenol preserved parenteral vaccines. Live attenuated Typhoid vaccine.
Local side effects are common
Severe systemic side effect
Contra indicated in HIV
Can be given with other vaccines like Hepatitis B & Yellow fever
Systemic Bacteriology (Gram Positive Bacilli, Gram Negative Bacilli)