The mechanism by which smoking accelerates vascular injury is?
Smoking impacts on and potentiates the mechanisms at three separate stages of the development of vascular disease (atherosclerosis):1) Endothelial dysfunction2) Monocyte recruitment and development of the plaque3) Thrombosis at the damaged vessel wallRef: The Nature Of Disease: Pathology For The Health Professions, By Thomas H. McConnell, Page 279
Retention of sodium
Increased aldosterone production
Promoting endothelial dysfunction
Increasing plasma catecholamines