Which of the following is/ are a side effect/s of Dapaglifozin?
Ans. is 'd' i.e., All the above Dapaglifozin* Dapagliflozin is an oral hypoglycemic drug of the gliflozin class, used to treat type 2 diabetes.* Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter mechanism causes blood glucose to be eliminated through the urine.* After single daily dose it produces round the clock glycosuria and lowers blood glucose levels.* Since dapagliflozin leads to heavy glycosuria (sometimes up to about 70 grams per day) it can lead to rapid weight loss and tiredness.* The glucose acts as an osmotic diuretic (this effect is the cause of polyuria in diabetes), which can lead to dehydration.* The increased amount of glucose in the urine can also worsen the infections already associated with diabetes, particularly urinary tract infections and thrush (candidiasis).* Dapagliflozin is also associated with hypotensive reactions. There are concerns it may increase the risk of diabetic ketoacidosis.
Increased weight loss
Polyuria
Increased incidence of urinary tract infections
All the above
Endocrinology