A patient with cancer received extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a particular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment in that patient during radiotherapy in order to prevent radiation toxicity –
Actinomycin - D (Dactinomycin) is well is well known radiosensitizer. So its dose should be reduced during radiotherapy to prevent radiation toxicity.
Vincristine
Dactinomycin
Cyclophosphamide
6 – Mercaptopurine