All are true about Gilbe's syndrome except ?
Ans. is 'a' i.e., Mild conjugated hyperbilirubinemia Gilbe syndrome o Gilbe syndrome is a type of congenital unconjugated hyperbilirubinemia. It is autosomal dominant. o Hepatic biochemical tests are normal There is normal hepatic histology, but in some patients increased lipofuscin pigment may occur. There is mild increase in unconjugated bilirubin --> No kernicterus o Defect is ? a) Decreased hepatic uptake of bilirubin b) Decreased activity of UDP G transferase o Phenobarbitone decreases the level of unconjugated bilirubin by increasing its conjugation --> Phenobarbitone induces UDPG transferase activity. o Hemolysis may be seen. o The disposition of most xenobiotics metabolized by glucronidation appears to be normal except for antitumor drug irinotecan.
Mild conjugated hyperbilirubinemia
Autosomal dominant
Nonnal liver histology
Almost normal liver function tests