A child is born with a single functional copy of a tumor suppressor gene. At the age of 5 years, the remaining normal allele is lost through mutation. As a result, the ability to control the transition from G1 to the S phase of the cell cycle is lost. Which of the following neoplasms is most likely to arise by means of this mechanism-
Robbins basic pathology 9th edition page no 182,Heading =RB gene Approximately 90 % of Retinoblastoma gene is sporadic, the remaining ones are familial, the predisposition to develop the tumor being transmitted as an autosomal dominant trait. Here all other conditions except Retinoblastoma are not associated with tumor suppresor gene defect.
Retinoblastoma
Breast carcinoma
Adenocarcinoma of colon
Cerebral astrocytoma
General pathology