Which of the following factors has maximum effect on filtration of a drug by the glomerulus ?
- Main Factors determining glomerular filtration

   Renal blood flow
   Plasma protein binding

- Lipid solubility does not affect glomerular filtration.
- Ionization determines tubular reabsorption. 
- Tubular secretion happens after glomerular filtration and so does not affect the process.
Lipid solubility
Plasma protein binding
Degree of ionization
Rate of tubular secretion