Most common cause of hereditary spherocytosis?
About 60% of HS cases results from a defect in the ankyrin-spectrin complex , with genes for a or b subunits of spectrin dimer (SPTA1 ,SPTB) or for ankyrin (ANK1)being implicated in diff genetic type. 25% ~> involve deficiency in band 3, the anion channel. Ref:Postgraduate Hematology by Victor Hoffbrand ,pg:131 Ref Robbins 9/e pg 412
Actin
Glycophorin
Spectrin-Ankyrin complex
Band 4
Haematology