Which of the following occurs in chronic granulomatous disease?
Ans: b (Defective H2O2 production) Ref: Ananthanarayan, 7th ed, p. 157; Harrison, 16th ed, p. 354Chronic granulomatous disease is a disorder of microbial killing characterized by decreased ability of neutrophils to produce H2O2 Patients become succeptible to catalase producing organisms which destroy the small amount of H2O2 in these cells leading to bacterial killing.Granulomas are produced as a 2nd line of defence against organisms, that normally would be removed by acute inflammatory response.Enzyme defect - N ADPH oxidaseScreening test - NBT test (nitroblue tetrazolium dye not reduced by neutrophils in vitro)
Myeloperoxidase deficiency
Defective H2O2 production
Defective polymerization
Defective phagocytosis
Inflammation & Repair