Which of the following is the mechanism of action of bumetanide?
Bumetanide is a loop diuretic. It inhibits the sodium, potassium, chloride cotranspoer in the thick ascending limb of the loop of Henle. Angiotensin conveing enzyme inhibitors include benazepril, captopril and lisinopril. They interfere with the conversion of angiotensin I to angiotensin II. Carbonic anhydrase inhibitors, such as acetazolamide, act in the proximal convoluted tubule. They cause a self-limited sodium bicarbonate diuresis. They are used to alkalinize the urine, and for the treatment of metabolic alkalosis and glaucoma. Potassium-sparing diuretics such as spironolactone, triamterene, and amiloride inhibit the action of aldosterone. They are used in the treatment of hyperaldosteronism and potassium depletion. Also Know: Loop diuretics inhibit a specific ion transpo protein, the Na+-K+-2Cl- sympoer on the apical membrane of renal epithelial cells in the ascending limb of the loop of Henle to increase Na+ and fluid delivery to distal nephron segments. These drugs also enhance K+ secretion, paicularly in the presence of elevated aldosterone levels, as is typical in CHF. Ref: Maron B.A., Rocco T.P. (2011). Chapter 28. Pharmacotherapy of Congestive Hea Failure. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.
Angiotensin conveing enzyme inhibitor
Carbonic anhydrase inhibitor
Loop diuretic
Potassium sparing diuretic