Effect of Potassium ionophore valinomycin on beta cells of pancreas is?
(a) Decrease the secretion of insulinRef: style="font-size: 1.04761904761905em; font-family: Times New Roman, Times, serif"> and http://www. eje-online. org/content/88/1/113Valinomycin interferes with the insulin releasing effect of glucose by increasing the potassium permeability of the B cell membrane.About ValinomycinIt is a member of the group of natural neutral ionophores because it does not have a residual charge. It is highly selective for potassium ions within the cell membrane and functions as a potassium-specific transporter. It facilitates the movement of potassium ions through lipid membranes "down" the electrochemical potential gradient. A very little literature is available regarding valinomycin.Theoretically, hyperpolarization of beta cells due to increased K+ permeability caused by valinomycin may lead to inhibition of insulin release (depolarization is needed for insulin release from beta cells).
Decrease the secretion of insulin
Insulin secretion increases
C-peptide secretion increases
Increase secretion of both insulin and C- peptide
Endocrinology