Most Common enzyme deficient in galactosemics:
Dulcitol or galactitol is the alcohol formed after reduction of galactose by enzyme aldosereductase. Excess dulcitol causes oil drop cataract in galactosemia patients. ADDITIONAL EDGE: C/F LIVER -JAUNDICE, HEPATOMEGALY BRAIN -MENTAL RETARDATION Oil drop cataract in galactosemic patient occurs due to deficiency of enzymes GALT (Classical Type Galactosemia) mainly and Galactokinase (Minor Type Galactosemia). Excess sorbitol (formed after reduction of glucose) causes snow flake cataract in diabetic patients.
Galactose-1-phosphate uridyl transferase/GALT
Galactosidase
UDP galactose epimerase
Galactokinase
FMGE 2018