All are ADP inhibitors except -
Ans. is 'b' i.e., Tirofiban Antiplatelet drugs* Antiplatelet drugs act by inhibiting one or other proaggregative mediators or mechanism.* Aspirin (in low doses) - inhibits synthesis of TXA2 by inhibiting the enzyme cycloxygenase So that immediate precursor (prostaglandins) of TXA2 are not synthesized.* Ticlopidine, clopidogrel, Prasugrel - they block ADP mediated platelet activation by irreversible antagonism of P2 Yl2 receptor on ADP. Can grelor and ticagrelor - are reversible antagonist of ADP (P2 Y12), in contrast to ticlopidine, which is irreversible antagonist.* Dipyridamol - Inhibits phosphodiesterase - | cAMP, It also blocks uptake of adenosine.* Epoprostinol - A prostacyclin - | cAMP.* Abciximab, eptifibatide, tirofiban, Lamifiban - GPIIb/IIIa inhibitors.* Cilastazole is a phosphodiesterase-3 inhibitors and result in elevated cAMP levels. It reduces platelet aggregation and also passess peripheral vasodilatory action. It can be used for the treatment of intermittent claudication.
Ticlopidine
Tirofiban
Clopidogrel
Prasugel
Hematology