Increased blood levels of cholesterol that are seen in hypothyroidism are most likely due to -
Ans- B Thyroid hormone increases the hepatic expression of LDL receptor. Hence in hypothyroidism there is reduction in hepatic LDL receptor So there is reduced clearance of LDL.
Decreased calorigenesis
Decreased production of LDL receptor in liver and the thus decreased clearance by liver
Decreased production of LDL receptor in the adipose tissue and increased release of cholesterol from adipose tissues
Increased breakdown of lipoproteins releasing cholesterol in circulation