All are seen in Thalassemia major EXCEPT:
Ans. (d) Macrocytic anaemiaRef. Robbins pathology 9th ed. /638* Thalassemia major presents before 1 yr of age with severe anemia which necessitates packed RBC transfusions every 2-3 months. The child is said to be transfusion dependent as survival is decided by RBC being transfused.* The ineffective erythropoiesis in bone marrow results in shift of hematopoiesis to liver and the bone marrow. Hence the liver and spleen enlarge in size. But the net result is defective microcytes being produced. The type of anaemia is microcytic hypochromic anaemia.* Remember: causes of MACROCYTIC ANAEMIA: "ABCDEF":# Alcohol + liver disease# B12 deficiency# Compensatory reticulocytosis (blood loss and hemolysis)# Drug (cytotoxic and AZT)/ Dysplasia (marrow problems)# Endocrine (hypothyroidism)# Folate deficieny/Fetus (pregnancy)
Transfusion dependency
Splenoheptatomegaly
Ineffective erythropoiesis
Macrocytic anemia
Hemolytic anemia