The rate-limiting step in the synthesis of coisol is catalyzed by
The first and rate-limiting step in all steroid biosynthesis is catalyzed by cholesterol sidechain cleavage enzyme, resulting in pregnenolone and isocaproic acid.
21-Hydroxylase
3b-Hydroxysteroid dehydrogenase
Cholesterol side-chain cleavage enzyme
11b-Hydroxylase
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