Following are seen in polycythemia vera except: September 2011
Ans. B: Increased erythropoietin The combination of iron deficiency anemia, glossitis and esophageal dysphagia usually related to the webs is known as the Plummer Vinson syndrome or Paterson Kelly syndrome. Plummer-Vinson syndrome/PVS/Paterson-Brown-Kelly syndrome/sideropenic dysphagia It presents as a triad of dysphagia (due to esophageal webs), glossitis, and iron deficiency anemia. In primary polycythemia, there may be 8 to 9 million and occasionally 11 million erythrocytes per cubic millimeter of blood (a normal range for adults is 4-6), and the hematocrit may be as high as 70 to 80%. In addition, the total blood volume sometimes increases to as much as twice normal.
Most common cause of polycythemia
Increased erythropoietin
Erythropoietin independent growth of red cell progenitors
Intrinsic abnormality of hematopoietic precursors