Which of the following statements is true about steady state?
Steady state is achieved when rate of administration is equal to rate of elimination Three impoant points to remember: Steady state is achieved within 4-5 half lives Dosing rate (dose per unit time) determines the average plasma concentration obtained at steady state. Frequency - drug when given intermittently, concentration will vary around baseline - peak and trough are obtained Longer interval - difference between peak and trough is more Lesser the interval - difference between peak and trough is less
It does not depend upon half life
Plasma concentration achieved is independent of dose rate
Longer is dosing interval, lesser is the difference between peak and trough values
Rate of administration is equal to rate of elimination
Pharmacokinetics