According to the latest evidence the latent virus infection which is responsible for the pathogenesis of the achalasia is:
It is believed that cause of ganglion cell degeneration in achalasia is an autoimmune process attributable to a latent infection with human herpes simplex virus 1 combined with genetic susceptibility. Ref: Harrison, Edition-18, Page-2431.
Herpes simplex 1
Hepatitis C infection
Rubella
Measles