Wof agent is used to prevent hemorrhagic cystitis caused by cyclophosphamide and ifosfamide
To prevent hemorrhagic cystitis mesna is routinely given with the drugs. Mesna is a -SH compound that is excreted in urine--binds and inactivates the vasicotoxic metabolites(Acrolein) of ifosfamide and cyclophosphamide. Ref:- kd tripathi; pg num:-860
Busulfan
Carmustine
Mesna
Niacin
Chemotherapy