In case of anisocoria when 1% pilocarpine is instilled into the eye with abnormally dilated pupil, pupil remains dilated. Cause of anisocoria maybe-
Pharmacological tests for suspected parasympathetic palsy. Pilocarpine test is used to determine if a dilated pupil is due to 3rd nerve palsy, pharmacological mydriasis, or tonic pupil. Pupil constricts to low concentration of pilocarpine (0.125%): Adies tonic pupil. Pupil constricts to usual concentration of pilocarpine (1 to 2%): 3rd nerve palsy. Pupil does not constrict with pilocarpine: mydriasis due to parasympathetic drugs, other conditions where dilated pupil does not constrict with pilocarpine are traumatic mydriasis and fixed pupil in irits. Ref AK khurana 6/e p 317
Adies pupil
Pharmacological blockage
Uncal herniation
Diabetic III cranial nerve palsy
Neuro-ophthalmology