Macrophage, granuloma, erythrophagocytosis are found ina)  Ulcerative colitisb) Necrotising enterocolitisc)  Regional ileitisd)  Typhoid
There is confusion between option c & d because macrophage and granuloma are seen in crohn's disease (Regional ileitis), while erythrophagocytosis is seen in typhoid fever.
- Regional Ileitis or crohn's disease has the histological features of transmural inflammatory cell infiltrate consisting of chronic inflammatory cells (lymphocytes, plasma cells & macrophges) which is the classical microscopic feature. Noncaseating, sarcoid like granulomas are present in all the layers of the affected bowel wall in 60% of cases & may even be seen in the regional lymph nodes. There is also patchy ulceration of the mucosa which may take the form of deep fissures, widening of submucosa due to edema & foci of lymphoid aggregates.
- In typhoid fever, there is hyperemia, edema and cellular proliferation consisting of phagocytic histiocytes, lymphocytes & plasma cells. There is phagocytosis of RBC → erythrophagocytosis.
ab
bc
cd
ac