Hypercoagulation in nephrotic syndrome is caused by-
Patients with nephrotic syndrome may develop spontaneous aerial or venous thrombosis, renal vein thrombosis and pulmonary embolism due to various factors. These include increased urinary loss of antithrombin III, hyperfibrinogenaemia from the increased synthesis in the liver decreased fibrinolysis, increased platelet aggregation and altered levels of protein C and S. Ref: Textbook of pathology Harsh Mohan 6th edition page 661
Loss of antithrombin III
Decreased fibrinogen
Decreased metabolism of Vitamin K
Increase in protein C
Urinary tract