Methemoglobinemia is caused by:
Ans. (A) Prilocaine(Ref: Katzung 11th/e p449)The administration of large doses (>10mg/kg) of prilocaine during regional anesthesia may lead to accumulation of the metabolite o-toluidine, an oxidizing agent capable of converting hemoglobin to methemoglobin.The treatment of methemoglobinemia involves the intravenous administration of reducing agents (eg. methylene blue or ascorbic acid), which rapidly convert methemoglobin to hemoglobin.
Prilocaine
Ropivacaine
Bupivacaine
Procaine
Anaesthesia