True statement regarding first order kinetics is:
Ans. (B) A constant proportion of plasma concentration is eliminated per unit time(Ref: RID 8th/e p38-39)In first order kinetics, rate of elimination is proportional to plasma concentration of the drug. Half life and clearance are constant in first order kinetics.
Rate of elimination is independent of plasma concentration
A constant proportion of plasma concentration is eliminated per unit time
Half life increases with dose
Clearance decreases with dose
General Pharmacology