Anti-inflammatory action of coicosteroids is due to blocking of-
Ans. is 'd' i.e., Breakdown of phospholipids o The most impoant mechanism of coicosteroids as antiinflammatory agents is the limitation of recruitment (chemotaxis) of inflammatory cells at the local side and production ofproinflammatory mediators like PGs, LTs, PAF through inhibition ofphospholipase At o Phospolipase A, acts on membrane phospholipids and causes their breakdwon to form arachidonic acid. This is inhibited by coicosteroids.
15 Lipo oxygenase
Prostaglandin synthases
Thromboxane synthases
Breakdown of phospholipids