'Syndrome of apparent mineralocoicoid excess' is due to deficiency of
Syndrome of apparent mineralocoicoid excess is due to genetic deficiency of 11b-dehydrogenase-2, cause hypokalemia. Liddle's syndrome is caused by autosomal dominant gain-in-function mutations of ENaC subunits, cause hypokalemia. Loss of the transpo functions of the thick ascending loop of Henle and distal convoluted tubule nephron segments causes hereditary hypokalemic alkalosis, Bater's syndrome (BS) and Gitelman's syndrome (GS), respectively. Ref: Harrison 19e pg: 305
11a--hydroxysteroid dehydrogenase
11b--hydroxysteroid dehydrogenase
12a--hydroxysteroid dehydrogenase
12b--hydroxysteroid dehydrogenase
Fluid and electrolytes