Liver biopsy is indicated in patients with hemochromatosis only if:
Screening tests for hemochromatosis are: transferrin saturation or ferritin level (Both will be high) Confirmatory test for hemochromatosis: Genetic testing (C282Y homozygote or a compound heterozygote (C282Y/H63D). If the ferritin is >1000 g/L, the patient should be considered for liver biopsy. Ref: Harrison, E-18, P-2603.
Elevation of transaminase present
Serum ferritin > 1000 g/L
Evidence of cirrhosis
If percentage saturation of iron is high