A 1-year-old child presented with involuntary movements which were choreoathetoid in nature, spasticity, dystonias and intellectual disability. The speech of the child was dysahric and mother also gave history of compulsive biting. Some inherited disorder was suspected. The child was normal at bih. Lab findings revealed increased uric acid levels. The enzyme deficient in the above condition catalyses which of the following reactions.
This is a case of Lesch-nyhan syndrome due to the deficiency of enzyme HGPase.
Guanine to GMP
GMP to guanine
Adenine to AMP
AMP to adenine
Integrated QBank