A 2 month old baby with acute viral hepatitis like illness slips into encephalopathy after 48 hours. The mother is a known hepatitis B carrier Mother's hepatitis B virus serological profile is most likely to be:
(B) HbsAg and HbeAg positive # This patient has developed a fulminant form of disease after acquiring an Hepatitis B infection from the mother who is known to be a hepatitis carrier.> HbsAg and HbeAg positive as mothers with this profile are most likely to transmit the disease to their infants.> Remember: The major predictor for transmission is the amount of HbV in the maternal circulation. Although HBV DNA positivity should also be an important indicator of vertical transmission.
HbsAg positive only
HbsAg and HbeAg positive
HbsAg and Hbe antibody positive
HBVDNA positive
Misc.