Syndrome of apparent mineralocoicoid excess is due to?
Coisol can stimulate mineralocoicoid receptors. But renal inactivation of coisol occurs to form coisone and thereby BP remains normal. SAME (Syndrome of Apparent Mineralocoicoid Excess) leads to lack of this inactivation. The resultant increase in coisol leads to excess activation of mineralocoicoid receptor and results in hypeension.
Increased aldosterone production
Lack of inactivation of aldosterone
Increased coisol production
Lack of Inactivation of coisol to coisone
Disorders of Adrenal Gland