The drug inhibiting DNA-dependent RNA polymerase in Mycobacteria is -
Ans. is 'b' i.e., Rifampicin Mechanism of action of impoant antitubercular drugs o Rifampicin --> Inhibits DNA dependent RNA synthesis by inhibiting RNA polymerase. o INH --> Inhibits synthesis of mycolic acid which is a component of mycobacterial cell wall. o Pyrazinamide --> Inhibits synthesis of mycolic acid. o Streptomycin --> Inhibits protein synthesis (translation). o Ethambutol --> Inhibits incorporation ofmycolic acid into bacterial cell wall by inhibiting arbinosyltransferase.
INH
Rifampicin
Ciprofloxacin
Ethionamide