An Rh-ye woman became pregnant with Rh+ve fetus. Within few days after bih, the infant developed jaundice, ascites, hepatomegaly and edema. The likely substance (s) deposited in skin and sclera in jaundice is/are given below. Which is the best possible answer-
Ans. is 'b' i.e., Conjugated and unconjugated bilirubinIt is a case of erythroblastosis fetalis.o In erythroblastosis fetalis there is excessive breakdown of RBC's. Leading to increased production of bilirubin in the blood. This increased bilirubin is predominantly unconjugated but there is some increase in conjugated bilirubin too. "The canalicular mechanisms responsible for bilirubin excretion are also immature at bih, and their maturation may lag behind that of UGT1A1, this can lead to transient conjugated neonatal hyperbilirubinemia, especially in infants with hemolysis". o You should also know this impoant fact.o Hemolysis in otherwise normal individual results in purely unconjugated hyperbilirubinemia.
Biliverdin
Conjugated and unconjugated bilirubin
Unconjugated bilirubin
Conjugated bilirubin