Which of the following statements regarding barbiturates is accurate ?
Barbiturates are acidic drugs. These are ionized in the alkaline urine and thus cannot be reabsorbed. Alkalinization of urine can be used to accelerate the elimination of barbiturates in poisoning.
Other differences between benzodiazepines and barbiturates include.
Benzodiazepines exhibit a steeper dose response relationship as compared to barbiturates
Barbiturates may increase the half lives of drugs metabolized by the liver
Alkalization of the urine will accelerate the elimination of phenobarbital
Respiratory depression caused by barbiturate overdosage can be reversed by flumazenil