A 5 year old child suffering from nephrotic syndrome is responding well to steroid therapy. What would be the most likely finding on light microscopy?
Ans. is 'a' i.e., No finding Minimal change disease o Minimal Change Disease is the most common cause of Nephrotic syndrome in children. Edema and Selective proteinuria are features of nephrotic syndrome. Fever may be present on account of increased susceptibility to infection. o Minimal change disease prsents with insidious onset of nephrotic syndrome in children below 6 years of age. o Hypeension is not a feature of nephrotic syndrome and is rare in Minimal change disease. Hematuria (a finding of nephritic syndrome) is also rare. Pathological findings include 1. Light microscopy ---> No abnormality 2. Electron microscopy ----> Obliteration (loss) and fusion of foot processes of epithelial cells. 3. Immunofluorescence --> No deposits of immune reactants 4. Serum complements --> Normal levels o Minimal change disease has very good prognosis with excellent response to steroids.
No finding
Basement membrabne thicking
Hypercellular glomeruli
Fusion of foot processes