All of the following features may be used to distinguish PAN from microscopic Polyangitis, Except:
Answer is C (Necrotizing vasulitis): Both polyaeritis nodosa and microscopic polyangitis are characterized by histologicaly by necrotizing vasculitis. Clinical Features PAN MPA Kidney Involvement * Renal vasculitis with infarcts and microaneurysms Yes No * Rapidly progressive glomerulonephritis with crescents No Yes Lung involvement * Alveolar hemorrhage No Yes Laboratory data Yes (10%) No * HBV-infection * ANCA Negative Positive (p-ANCA) Abnormal angiogram with microaneurysms Yes No * Histology Necrotizing vasculitis Necrotizing vasculitis (no granulomas) * Relapses Rare Common
ANCA positivity
RBC cast in urine
Necritizing vasculitis
HBV infection