RET proto oncogene mutation is a hallmark of which of the following tumors?
Ans. is 'a' i.e. Medullary carcinoma thyroid Mutations in RET proto-oncogene are responsible for MEN2A, MEN2B, and Familial Medullary thyroid carcinoma. RET protooncogene codes for trans-membrane protein tyrosine kinase Familial cases of MTC are now detected by genetic screening for RET mutations, which identifies individuals who will develop medullary cancer later in life.
Medullary carcinoma thyroid
Astrocytoma
Paraganglioma
Huhle cell tumor thyroid