Following are seen in polycythemia vera except:
Polycythaemia Polycythaemia vera (PV) is a clonal disorder characterized by increased production of all myeloid elements resulting in pancytosis (i.e increased red cells, granulocytes, platelets) in the absence of any recognizable cause. The term 'polycythemia vera' or 'polycythemia rubra vera' is used for primary or idiopathic polycythemia only and is the most common of all the myeloproliferative disorders. Secondary polycythemia or erythrocytosis, on the other hand, may occur secondary to several causes e.g. high altitude, cardiovascular disease, a pulmonary disease with alveolar hypoventilation, heavy smoking, inappropriate increase in erythropoietin (renal cell carcinoma, hydronephrosis, hepatocellular carcinoma, cerebellar hemangioblastoma, massive uterine leiomyoma); clinical features: headache, veigo, tinnitus, visual alterations syncope or even coma. Increased risk of thrombosis due to accelerated atherosclerosis. Increased risk of hemorrhages due to increased blood volume and intrinsic platelet dysfunction e.g. epistaxis, peptic ulcer disease Splenomegaly producing abdominal fullness. Pruritus, especially after a bath REF: ROBBINS pathology 10th edition
Most common cause of polycythemia
Increased erythropoietin
Erythropoietin independent growth of red cell progenitors
Intrinsic abnormality of hematopoietic precursors
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