"Orphan Annie eye nuclei" is characteristic histologic feature of which of the following thyroid malignancy ?
Orphan Annie nuclei is a characteristic intranuclear inclusion seen mainly in papillary carcinoma of thyroid. Ultrastructurally they are seen as membrane bound spheroidal masses of cytoplasm intruding into the nuclei. Intranuclear inclusions are less commonly seen in hyalinizing trabecular adenomas, medullary carcinoma, huhle cell carcinoma as well as anaplastic carcinoma.
Papillary carcinoma of thyroid
Medullary carcinoma of thyroid
Anaplastic carcinoma of thyroid
Follicular carcinoma of thyroid