All of the following can be administrated in acute hypertension during labour except:
Ans. d. IV diazoxide (Ref: http;//www.drugs.com/pregnancy/diazoxie.html; http//www.rxlist.com/nitropress-drug/warnings -precautions, htm)Both nitroprusside and diazoxide are pregnancy category C drugs, should not be used during pregnancy. But as the question specifically asks 'during labour', if diazoxide is given during labor, it may stop uterine contractions, requiring use of an oxytocic agent. The better answer to go with is diazoxide.Warning for Nitroprusside During PregnancyNitroprusside belongs to pregnancy category C.There are no adequate, will-controlled studies of nitroprusside sodium in either laboratory- animals or pregnant women. It is not known whether it can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Nitroprusside sodium should be given to a pregnant woman only if clearly needed.In three studies in pregnant ewes, nitroprusside was shown to cross the placental barrier and cause fetal cyanide poisoning. Diazoxide has been assigned to pregnancy category C by the FDA.It is not indicated for use during pregnancy.Animal studies have shown evidence of reduced fetal growth and fetal and/or pup survival in addition to prolonged parturition.There are no adequate or controlled data from human pregnancy studies.Diazoxide should only be used during pregnancy when need has been clearly established.If given during labor, diazoxide may stop uterine contractions, requiring use of an oxytocic agent.
IV labetalol
IV nitroprusside
IV dihydralazine
IV diazoxide
Pharmacology in Gynaecology