A patient presented with diarrhea, poor appetite and malabsoption. His duodenal biopsy was taken which showed crypt hyperplasia, villous atrophy and infiltration of CD8+ T cells in the epithelium. What is the likely diagnosis of the patient?
Celiac disease is caused by sensitivity to gluten in cereal products Clinical manifestations include weight loss, weakness, and diarrhea with pale, bulky, frothy, foul-smelling stools. In children, it is also characterized by growth retardation and general failure to thrive. It is more common in patients with Type I diabetes mellitius. Diagnosis involves documentation of malabsorption, small intestinal biopsy demonstrating blunting of small intestinal villi, the presence of Ig-A endomysial and anti-tissue transglutaminase antibodies, and clinical improvement and restoration of normal intestinal morphology on a gluten-free diet. Incidence increases in association withhuman leukocyte antigens (HLAs) HLA-B8 and HLA-DW3. This finding and the presence of antibodies directed against gliadin (a glycoprotein component of gluten) and transglutaminase suggest that both genetic and immune-mediated mechanisms may be involved. These antibody tests may also be used for screening prior to definitive diagnosis by biopsy. Enteropathy-type t-cell lymphoma develops in a subset of patients. 2. Other malabsorption syndromes include tropical sprue, Whipple disease, disaccharidase deficiency, abetalipoproteinemia, and intestinal lymphangiectasia. Malabsorption can also be caused by pancreatic insufficiency.
Environmental enteropathy
Celiac disease
Whipple disease
Pancreatitis
NEET Jan 2020