The normal cellular counterpas of oncogenes are impoant for the following functions, except ?
o Normal cellular counterpa of oncogene is protooncogene.o The functions of protooncogene is to code forGrowth factorsGrowth factor receptorsProteins involved in signal transductionNeuclear regulatory proteins (transcription factors)Cyclins/CDKso All these lead to cell proliferation and progression of cell cycle.o When any of these protooncogenes becomes oncogene by mutation / overexpression, there is uncontrolled proliferation of cell and development of cancer.This proliferation is autonomous, i.e. without physiological stimulus.
Promotion of cell cycle progression
Inhibition of apoptosis
Promotion of DNA repair
Promotion of nuclear transcription