Apparent volume of distribution of a drug exceeds total body fluid volume, if a drug is -
Ans. is 'a' i.e., Sequestrated in body tissues o Drug may have volume of distribution for in excess of total body water if it is sequestered in other tissues because most of the drug is present in tissues and plasma concentration is low.
Sequestrated in body tissues
Slowly eliminated from body
Poorly soluble in plasma
Poorly bound to plasma protein