Which of following HMG CoA reductase inhibitor has longest half life?
Rosuvastatin - Longest acting Pitavastatin - most potent - Statins have maximum LDL lowering capacity. - Given at night because HMG CoA reductase is maximum active at night but Atorvastatin and Rosuvastatin are long acting drugs, thus can be given any time of the day. - Statins can cause myopathy
Atorvastatin
Simvastatin
Rosuvastatin
Pitavastatin
Hypeension, Arrhythmias, Dyslipidemia