Unconjugated hyperbilirubinemia is seen in all EXCEPT
(B) Dubin Johnson syndrome # Common causes of Raised Bilirubin and Urobilinogen:> Raised conjugated bilirubin (bilirubinuria): Hepatocellular disease and post-hepatic or cholestatic disease (intrahepatic and extrahepatic), including drug toxicity as well as pancreatic causes of obstructive jaundice. Inherited defects in excretion - Eg, Dubin-Johnson syndrome, Rotor's syndrome.> Raised unconjugated bilirubin (no bilirubinuria): Gilbert's syndrome Haemolysis Post viral hepatitis Mild chronic hepatitis Crigler-Najjar syndrome# Physiologic Jaundice (non-pathologic unconjugated hyperbilirubinemia):> Term Infants: 50-60 % of all newborns are jaundiced in the first week of life. Total serum bilirubin peaks at age 3-5 d (later in Asian infants). Mean peak total serum bilirubin is 6 mg/dL (higher in Asian infants).> Preterm Infants: Incidence of visible jaundice is much higher than in term infants. Peak is later (5-7d). Because of increased risk of bilirubin encephalopathy (see below), "physiologic" jaundice is more difficult to define and jaundice should be followed closely.
Gilberts syndrome
Dubin Johnson syndrome
Crigler Najjar syndrome
Neonatal physiological jaundice
Miscellaneous