Which of the following condition is associated with an increased risk of developing adenocarcinoma of esophagus?
The metaplasia of esophageal squamous epithelium to columnar epithelium (Barrett's esophagus) is a complication of severe reflux esophagitis, and is a risk factor for esophageal adenocarcinoma. Endoscopic biopsy is the gold standard for confirmation of Barrett's esophagus. The hallmark of Barret's esophagus is the presence of mucus secreting goblet cells. Ref: Schwaz's Principles of Surgery, 9th Edition, Chapter 25
Barret's esophagus
Long standing achalasia
Corrosive structure
Alcohol abuse