Valproate is preferred over lithium in all of the following conditions except:
In elated or euphoric mania, lithium is preferred. In rest of the options, valproate is preferred. In renal compromise, lithium is avoided due to its renal side effects. Lithium Indications: 1. Acute manic episode 2. Bipolar depression 3. Maintenance treatment- it reduces severity, frequency and duration of both manic and depressive episodes 4. Antisuicide propey 5. Schizoaffective disorder 6. Major depressive disorder 7. Neutropenia 8. OCD 9. Headache (cluster headache, migraine) 10. Ulcerative colitis
Elated mania
In renal compromise
Dysphoric mania
Mania with psychosis
Mood Disorders