Patient was given chloroquine and doxycycline for 7 days. Patients fever decreases in 4 days, but, peripheral smear showed occasional gametocytes of plasmodium falciparum. This type of drug resistance is -
Ans. is `b' i.e., R2 type WHO classification of antimalarial drug resistance 1. S-sensitive --> If a sexual parasites have cleared by day 6 from the begining of treatment wihout subsequent recrudescence until day 28. 2. R1-Low grade resistance --> Recrudescence of infection between 7-28 days of completing treatment. 3. R2-High grade resistance --> Reduction of parasitemia by more than 75% at 48 hours of completing treatment but failure to clear the organism within 7 days. 4. R3-4 Parasitemia does not fall by more than 75% within 48 hours of completing treatment and there is no subsequant clearance of asexual parasites.
R type
R2 type
R3 type
R4 type