Which antihypeensive is a prodrug and is coveed to its active form in brain?
(Ref: KDT 6/e p547) Although both methyldopa and minoxidil are produrgs, conversion of methyldopa to a-methylnorepinephrine takes place in the brain whereas minoxidil is activated to minoxidil sulphate (by phase II reaction) in the periphery.
Clonidine
Methyldopa
Minoxidil
Nitroprusside
Other topics and Adverse effects