All of the following are associated with pathogenesis of acute hydrops fetalis except: September 2009
Ans. C: Hypoplasia of Placental Tissue Several hypotheses regarding the pathophysiologic events that lead to fetal hydrops have been suggested. The basic mechanism for the formation of fetal hydrops is an imbalance of interstitial fluid production and the lymphatic return. The fetus is paicularly susceptible to interstitial fluid accumulation because of its greater capillary permeability, compliant interstitial compaments, and vulnerability to venous pressure on lymphatic return. In Rh hemolytic disease, there is excessive destruction of RBC's leading to anemia, tissue anoxemia and metabolic acidosis. There is hyperplasia of placental tissue in an effo to increase the transfer of oxygen. As a result of anoxemai there is damage to liver resulting in hypoproteinemia. Fluid accumulation in the fetus can result from congestive hea failure, obstructed lymphatic flow, or decreased plasma osmotic pressure.
Hypoproteinemia
Anemia
Hypoplasia of placental tissue
Metabolic acidosis