Staph.aureus causes vomiting in 6-8 hours. The mechanism of action is:
From Harrison:
“Staph. food poisoning result from heat stable preformed enterotoxin. Due to preformed nature, incubation period is short. Toxin stimulates the vagus nerve and vomiting centre of brain. It also appears to stimulate intestinal persistaltic activity”.
Stimulation of cAMP
Vagal stimulation
Stimulation of cGMP
Acts through ganglioside GM receptor