Function of infliximab used in Crohn&;s is
Infliximab, a chimeric IgG1 antibody against TNF-a, is approved for treatment of moderately to severely active UC.Infliximab is also effective in CD patients with refractory perianal and enterocutaneous fistulasAdalimumab and ceolizumab, golimumab are other Anti-TNF therapies approved for IBDInfliximab is also approved for psoriasis, psoriatic ahritis, ankylosing spondylitis, and rheumatoid ahritisRef: Harrison 19e pg: 1961
Inhibit TNF-a
Inhibit IL-2
EGFR inhibitor
Inhibit VEGF
G.I.T