Hemolytic crisis in hereditary spherocytosis is precipitated by
Ans. (a) Parvovirus B19 infection(Ref: Harrison 18th/pg 1478)Aplastic/hypoplastic crises resulting from parvovirus B19 infection may occur in Hereditary spherocytosis just as is seen in individuals with other chronic hemolytic disorders.Parvovirus B19 selectively infects erythroid precursors and inhibits their growth.Erythropoietic arrest leads to a sudden decrease in hemoglobin concentration and reticulocytopenia.
Parvovirus B19 infection
Infectious mononucleosis
Human T-cell leukemia virus
Cytomegalovirus
Misc. (R.B.C)