Which of the following is not a minor diagnostic criteria for multiple myeloma ?
Plasmacytoma on biopsy DIAGNOSTIC CRITERIA OF MULTIPLE MYELOMA Major criteria (1) Plasmacytoma on tissue biopsy (2) Bone marrow plasmocytosis > 30% of plasma cells. (3) Monoclonal globulin spike IgG > 35g/1, or IgA > 20g/L (4) Light chain excretion on urine electrophoresis 1 g/24 hrs Minor criteria (1) Bone marrow plasmacytosis, 10-30% plasma cells. (2) Monoclonal globulin spike, IgG<35g/L or IgA < 20 g/L (3) Lytic bone lesions. (4) Normal IgM < 500 mg/L. IgA < 1 g/L or IgG < 6g/L Criteria for multiple myeloma (1) 1 major & 1 minor criteria OR (2) 3 minor criteria that must include 1 and 2 of minor criteria.
Lytic bone lesions
Plasmacytosis greater than 20%
Plasmacytoma on biopsy
Monoclonal globulin spike on serum melectrophoresis of >2.5 G/DL for IgG,>1.5 G/DL for IGA)