What is the pathogenetic mechanism of HPV in causing cervical carcinoma?
Reference : Robbins basic pathology 9th edition : the oncogene city of HPV is related to the expression of two viral oncoproteins,E6 and E7 they bind to Rb and p53,respectively neutralizing their function
Down regulation of 16INK4 protein
Degradation of cyclin D1
Genomic instability of E6 and E7
Up regulation of BCL2
General pathology