Which of the following statements regarding transfer of drugs across placenta is FALSE ?
Heparin and insulin are anticoagulant and antidiabetic drugs of choice, respectively in pregnancy becasue these have minimum entry across placenta
Fetal plasma is slightly more acidic than that of mother (pH 7.0 as compared to 7.4 of mother), so ion trapping of basic drugs occur.
Placenta contain P-glycoprotein that can act as an efflux pump for drugs.
Placental transfer of most drugs is greater in late pregnancy than in early pregnancy because uterine circulation increases and trophoblastic layer becomes thinner as the pregnancy advances.
Transfer across placenta is lesser in early pregnancy
All drugs to some extent can cross the placenta except heparin and insulin
Ion trapping of acidic drugs occur in the placenta
P–glycoprotein is present in placenta