In traumatic brain injury, changes in brain metabolism are seen. All are true EXCEPT
In Traumatic brain injury anaerobic condition prevails. So brain cells switch to anerobic metabolism producing increasing amount of lactate (Option B is correct). Now if this lactate is getting utilized as energy source within brain cells through TCA it is associated with good prognosis (means tissue is recovering from injury), However, if the lactate is not getting utilized in brain cells and it will be expoed out from cell in to CSF. This outcome means severe damage to brain cells so that they are not able to utilize lactate. Hence increased lactate levels in CSFare associated with poor prognosis. (but D is wrong) Pyruvate dehydrogenase activity is decreased due to hypoxic conditions. (Option A is correct) Now if this lactate is getting utilized as energy source within brain cells through TCA it is associated with good prognosis (means tissue is recovering from injury). However, if the lactate is not getting utilized in brain cells and it will be expoed out from cell in to CSF. This outcome means severe damage to brain cells so that they are not able to utilize lactate. Hence increased lactate levels in CSF are associated with poor prognosis. (but D is wrong) Also, increase lactate uptake from the circulation into brain cells is seen as the injured brain uses lactate as fuel. (Option C is correct)
There is a decrease of pyruvate dehydrogenase activity
There is accumulation of lactate in brain
There is | lactate uptake from circulation
| CSF lactate is associated with good prognosis
Glycolysis