Microglobulin β2 is seen in?
It is also important to quantitate serum β2-microglobulin. Serum β2-microglobulin is a protein of 11,000 mol. wt with homologies with the constant region of immunoglobulins that is the light chain of the class I major histocompatibility antigens (HLA-A, -B, -C) on the surface of every cell. Serum β2-microglobulin is the single most powerful predictor of survival and can substitute for staging. Patient with β2-microglobulin levels <0.004 g/L have a median survival of 43 months and those with levels >0.004 g/L only 12 months. Serum β2- microglobulin and albumin levels are the basis for a three-stage International Staging System (ISS). It is also felt that once the diagnosis of myeloma is firm, histologic features of atypia may also exert an influence on prognosis. IL-6 may be an autocrine and/or paracrine growth factor for myeloma cells; elevated levels are associated with more aggressive disease. High labeling index and high levels of lactate dehydrogenase are also associated with poor prognosis.
Multiple myeloma
SLE
Immunocompromised patient
None of the above