The quantity of globin chain synthesis is reduced in
Heme Synthesis. Heme is synthesized in a complex series of steps involving enzymes in the mitochondrion and in the cytosol of the cell (Figure 1). The first step in hemesynthesis takes place in the mitochondrion, with the condensation of succinyl CoA and glycine by ALA synthase to form 5-aminolevulic acid (ALA) Ref Robbins 9/e pg 413
HbS
Thalassemia
HbC
HbF
Haematology