Post-streptococcal glomerulonephritis is associated with -
Ans. is `a' i.e., Follows skin and throat infection Post streptococcal glomerulonephritis o PSGN appears 1 to 4 weeks after a streptococcal infection of pharynx or skin (impetigo). It is caused by ceain nephritogenic serotypes of group A f3-hemolytic streptococcus (not by all serotypes). o The lesions are caused by immune complex deposition and activation of complement --> complement level decreases. It occurs most frequently in children 6 to 10 years of age. o Clinically child presents with acute nephritic syndrome ? i) Hematuria iii) Azotemia v) Hypeension ii) Oliguric acute renal failure iv) Proteinuria vi) Edema o PSGN causes acute renal failure, but not chronic renal failure -> more than 95% of affected children eventually recover totally with conservative therapy. Treatment Management is directed at treating the acute effects of renal insufficiency and hypeension. o Although a 10 day course of systemic antibiotic therapy with penicillin is recommended to limit the spread of nephritogeric organisms, antibiotic therapy does not affect the natural history of glomerulonephritis.
Follows skin and throat infection
Antibiotic treatment induces remission
Is a cause of chronic renal failure in majority of children
All