Atropine is added with diphenoxylate to:
Ans: C (Decrease abuse potential) Ref: Basic & Clinical Pharmacology, 2012, 12th Ed, Tala McGraw hill, Katzung BG,Masters SB, Trevor AJ.P 1095Explanation:Diphenoxylate is an opioid agonist without any analgesic property.It has Antimotilitv action hence it is used in non-infective diarrhoeaIt can cause drug dependence since it has CNS effectsAtropine in small doses (0.025 mg) is added with diphenoxylate 2.5 mg to discourage overdose since this may cause atropine side effects which unpleasant
Increase effect
Decrease side effects
Decrease abuse potential
Enhance absorption
Anti Cholinergic