Mechanism of action of prophylthiouracil -
Ans. is 'd' i.e., Inhibits coupling o Propylthiouracil blocks thyroxine synthesis by inhibiting thyroid peroxidase, and preventing oxidation of iodide/ iodotyrosyl residues, there by1) Inhibit iodination of tyrosine residue in thyroglobulin.2) Inhibit coupling of MIT and DIT to form T3 & T4.o Propylthiouracil also inhibit the peripheral conversion of T4 to T3
Prevents synthesis of thyroglobulin
Prevents iodine trapping
Prevents release of T4 & T3
Inhibits coupling
Anti Thyroid