Which of the following does not cross the blood-brain barrier?
Ref: KD Tripathi pharmacology 7th edition (page.no: 111) Katzung 11/e p121 Pralidoxime has positively charged quaternary nitrogen. Quaernary molecules are heavy and can't penetrate the blood-brain barrier Pralidoxime or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to treat organophosphate poisoning in conjunction with atropine and diazepam
Pralidoxime
Obidoxime
Diacetyl-monoxime
Physostigmine
Autonomic nervous system