Which of the following causes hemolytic anemia -a) Hereditary spherocytosisb) Infectionc)  Iron deficiencyd) Sickle cell anemiae) Copper deficiency
Hemolytic anemia may be of two types.

 Intracorpuuscular

Underlying cause of hemolysis is intrinsic to RBC, e.g.,

Defect in membrane cytoskeleton → Hereditary spherocytosis
Defect in red cell enzyme → G6PD deficiency.
Disorder of hemoglobin synthesis 


Deficient globin synthesis →Thalassemia
Structurally abnormal globin → Sickle cell anaemia.
	(hemoglobinopathies)


Membrane defect → Paroxysmal nocturnal hemoglobinuria

                    2. Extracorpuscular
Underlying cause of hemolysis is extrinsic, ie., not within RBC, e.g., : -

Immunohemolytic anemia
Microangiopathic hemolytic anemia → (i) TTP,  (ii) HUS,  (iii) DIC
Infection → Malaria
Mechanical trauma to RBC → rosthetic valve.
Hyperspienism
abd
bcd
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