Wof is the most accurate statement regarding digoxin
CARDIAC GLYCOSIDES PHARMACOLOGICAL ACTIONS Hea:- Hea rate:-Hea rate is decreased by digitalis. Bradycardia is more marked in CHF patients because improved circulation (due to positive inotropic action) restores the diminished vagal tone and abolishes sympathetic overactivity. In addition, digitalis slows the hea by vagal and extravagal actions. Vagal tone:- is increased reflexly by sensitization of baroreceptors, as well as by stimulation of vagal centre. Extravagal:- A direct depressant action on SA and A-V nodes. This component of bradycardia is not reversed by atropine. Ref:- kd tripathi; pg num:-512,513
Increases vagal tone and decreases AV node conduction
Decreases moality in patients with congestive hea failure with normal sinus rhythm
Lengthens the action potential and increases the refractoriness of the hea
Useful in the treatment of Wolff-Parkinson-White syndrome
Cardiovascular system