An old patient Ram Kishore having asthma and glaucoma is to receive a b blocker. Regarding b blocking drugs:
Metoprolol is a cardioselective (b1 selective) blocker and not b2 selective. Esmolol is the shoest acting b -blocker and is useful for acute treatment. Nadolol is a non-selective b-blocker. It blocks both b1 as well as b2 receptors. Propanolol possesses maximum local anaesthetic activity whereas timolol lacks this propey.
Metoprolol blocks b2 receptors selectively
Esmolol's pharmacokinetics are compatible with chronic topical use
Nadolol lacks b2 blocking action
Timolol lacks the local anaesthetic effects of propanolol
ANS