Mechanism of action of progesterones in the medical management of endometriosis is?
Progesterones act by exeing an anti estrogenic effect and their continuous administration causes decidualisation and endometrial atrophy. The treatment over a period of 6 - 9 months produces a state of pseudopregnancy which ultimately causes regression of disease. It has no effect on ovulation Progestins used commonly are: Norethisterone Dydrogesterone Medroxyrogesterone acetate Mirena IUCD Dienogest
Deccidualisation and endometrial atrophy
Prevention of retrograde menstruation
Thickening of cervical mucous
Prevention of ovulation
Endometriosis, Adenomyosis