Which of the following is not true regarding super-antigens -
Superantigens Superantigens are potent activators of T-lymphocytes. Superantigens stimulate very large numbers of T cells, without relation to their epitope specificity. This leads to an excessive and dysregulated immune response with release of cytokines IL - 1, IL - 2, TNF - a and IF - y. Superantigens are capable of activating up to 20% of the peripheral T-cell pool, where as conventional antigens activate < 1 in 10, 000. For superantigens, antigen specificity of TCR is not required.
Bind T cells irrespective of antigen specificity of TCR
Bind directly to both MHC II and T cell receptor causing T cell activation
Bind to cleft (or antigen binding groov(e) in the MHC II molecule
Binds directly to lateral aspect of T cell receptor