In which of the following disorders,administration of barbiturates is contraindicated?
Barbiturates induce the rate limiting enzyme amino levulanic acid synthase in porphyrin synthesis. This increased synthesis of prophyrins can precipitate acute attack of AIP Ref: KD Tripathi 8th ed.
Anxiety disorders
Acute intermittent porphyria
Kernicterus
Refractory status epilepticus
Central Nervous system