In acute hepatitis B, all are raised except
Anti-HBc total antibodies (all classes of antibodies, ie IgG IgM) also increaseThe serological pattern of Hepatitis B virus:HBe Antigen positive chronic hepatitisHBe Antigen negative chronic hepatitis Replicative phase Non replicative phase HBV DNA ++HBeAg ++Intrahepatocyte HBcAg ++DNA polymerase ++HBV DNA very low HBeAg very low Intrahepatocyte HBcAg --Anti HBe ++HBV DNA ++HBeAg --DNA polymerase ++Hepatitis B patternSerological markersAcute Hepatitis BIg M Anti HBcAg ++ ; HBsAg ++Chronic Hepatitis B Ig G Anti HBcAg ++ ; HBsAg ++Marker of vaccination Anti HBsAg ++Marker of remote infection Ig G Anti HBcMarker of infectivity HBeAg Ref: Ananthanarayan 9th edition, p546-548
HBsAg
IgM anti-HbC
Anti HBsAb
Total anti-HbC
Virology