Which of the following is a most impoant infiltrate in rheumatoid ahritis?
Rheumatoid ahritis - Delayed hypersensitivity - Infiltration caused by CD4+ helper cells - Infiltration contribute to development of pannus - Involvement of small joints - IFN-g from TH 1 cells activates macrophages and resident synol cells. - IL-17 from TH 17 cells recruits neutrophils and monocytes. - TNF and IL-1 from macrophages stimulates resident synol cells to secrete proteases that destroy hyaline cailage. - RANKL expressed on activated T cells stimulates bone resorption. - Of these, TNF has been most firmly implicated in the pathogenesis of RA and TNF antagonists have proved to be remarkable effective therapies for the disease.
Dendritic cells
Macrophages
Neutrophils
CD4+ Helper cells
NEET 2018