All of the following factors tend to increase the volume of distribution of a drug except
Ref - katzung10/e p34,35 If a drug is highly bound to plazma proteins it is more likely to statin blood. Thus its Vd will be less. Low ionizition ours the distribution of drug because unionized molecules can cross the membrane of blood vessel and tissue.
High plasma protein binding
Low ionization at physiological pH values
High lipid solubility
High tissue binding
Other topics and Adverse effects