Tetracyclines inhibit protein synthesis by:
The tetracyclines are primarily bacteriostatic; inhibit protein synthesis by binding to 305 ribosomes in susceptible organism. Subsequent to such binding, attachment of aminoacyl-t-RNA to the mRNA-ribosomc complex is interferred with. ESSENTIALS OF MEDICAL PHARMACOLOGY page no. 734
Inhibition of initiation and misreading of mRNA
Binding to 30 S subunt and inhibiting the binding of aminoacyl-RNA to A site
Inhibiting peptidyl transferase activity
Inhibiting translocation
Chemotherapy