Drug not effctive in treating pediatric acute mania is:
Ans. C. OxcarbazepineExplanationUse of mood-stabilizing agents in pediatric patients (page 1300)Classic mania in children and adolescents is treated as it is treated in adults.Use of lithium in treating adolescent mania has been supported in many open trials. (Option a)Divalproex is used frequently to treat bipolar disorder in children and adolescents. (Option b)Quetiapine is at least as effective as divalproex in treating acute manic symptoms. Reduction of symptoms occurred more quickly with quetiapine compared with divalproex.Propranolol (Inderal) has been chosen as an agent to control aggression in open trials, although no evidence supports its use in children and adolescents.Carbamazepine (Tegretol) has not been shown to be effective in controlling aggression in child and adolescent conduct disorders. (Option d)About carbamazepine and oxcarbazepine (page 379)Carbamazepine has been used worldwide for decades as a first-line treatment for acute mania but has only gained approval in the United States in 2004.Typical doses of carbamazepine to treat acute mania range between 600 and 1,800 mg/day associated with blood levels of between 4 and 12 pg/mL.Oxcarbazepine (keto congener of carbamazepine), possess similar antimanic properties as carbamazepine. Higher doses than those of carbamazepine are required because 1,500 mg of oxcarbazepine approximates 1,000 mg of carbamazepine.Thus based on above discussion oxcarbazepine seems to be possible answer
Lithium
Divalproex
Oxcarbazepine
Carbamazepine
Pharmacotherapy In Psychiatry