Which of the following is the characteristic of a highly ionized drug?
A highly ionized drug is not reabsorbed by the tubules and is easily excreted by the kidneys because it is lipid insoluble. Ref: Dr J G Buch, (2010) Chapter 3, "Pharmacokinetics", "Clinically oriented pharmacology", Newdelhi, Page 13
High protein binding
Can cross placental barrier easily
Rapidly absorbed from stomach
Excreted mostly by the kidneys