Which of the following statements about Fluconazole is most accurate
Ref-KDT 6/e p761 Azoles act by inhibiting the enzyme lanosterol-14-alpha-demethvlase.resulting in reduced ergosterol synthesis. It has very good CNS penetration and oral bioavailability. It is not very effective against aspergillosis (voriconazole is thedrug of choice).
It is it effective in the treatment of Aspergillosis
It does not penetrate the blood brain barrier
It's oral bioavailability is less than that of ketoconazole
It inhibits demethylation of lanosterol
Other topics and Adverse effects