The mechanism of action of cyclosporine is:
Cyclosporine calcineurin inhibitor inhibits the dephosphorylation of NFAT leading to blocked of T cell activation by preventing IL2 Transcription. Tacrolimus (FK506):- is also calcineurin inhibitor which binds FK506 binding protein. IL2 receptor are blocked by Basiliximab, Daclizumab. TNF alphaBlocker :- Infliximab
Inhibits IL-2 receptors
Inhibits TNF alpha
Decrease in transcription of IL-2 gene
Targets inactivated T cells
DNB 2018