Angiotensin conveing enzyme inhibitors when used for a long time in patients with hypeension, cause:
Unlike the direct-acting smooth muscle vasodilators or adrenergic inhibitors, ACE inhibitors dilate the efferent as well as the afferent glomerular aerioles and thereby reduce glomerular hydrostatic pressure and renal filtration fraction, even though renal blood flow and glomerular filtration rate are preserved. Ref: KD Tripathi 8th ed.
Rightward shift in renal pressure-natriuresis curve
Reduction in glomerular filtration fraction
Significant increase in hea rate
No change in compliance of large aeries
Cardiovascular system