In Huntington’s chorea, neurons are affected in which part of brain?
Huntington’s chorea is an inherited genetic defect leading to the degeneration of neurons with the striatum (the caudate nucleus and putamen). It is progressive disease characterized by uncontrolled movements, irritability, depression, and ultimately dementia and death. Lesions of the subthalamic nucleus produce wild flinging movements called ballism; those within the anterior cerebellum produce ataxia; those within the substantia nigra produce Parkinson’s disease; and those within the limbic system yield emotional disorders.
Anterior cerebellum
Subthalamus
Striatum
Limbic system