The site of action of local anaesthetic in epidural anesthesia is
Local anaesthetic in maximal blockade is believed to act in spinal nerve root. Mechanism of action of central neuraxial blockade. The mechanisms of spinal and epidural are believed to be the nerve roots. Blockade of neural transmission in the posterior nerve root fibers interrupt somatic and visceral sensation, whereas blockade of anterior nerve root fibers prevent efferent motor & autonomic outflow.
Spinal nerve root
Spinal cord
Epidural neural tissue
Anterior root of spinal nerve
Central Neuraxial Blockade