A newborn baby presented with profuse bleeding from the umbilical stump after bih. Rest of the examination and PT, APTT are within normal limits. Most of probable diagnosis is -
TEXT BOOK OF PATHOLOGY HARSHMOHAN 6TH EDITION PG NO 334 DEFECTIVE PLATELET AGGREGATION . In thrombasthenia (Glanzmann's disease), there is failure of primary platelet aggregation with ADP or collagen due to inherited deficiency of two of platelet membrane glycoproteins.
Factor X deficiency
Glanzmann thrombasthenia
Von willebrand disease
Bernad soulier disease
Haematology