According to DOTS-PLUS guidelines 2013 treatment of multidrug resistance TB includes all except ?
Ans. is 'c' i.e., Continutation phase-2 drgus Treatment of multidrug resistance (MDR) TB MDR-TB is defined as resistance to at least both INH and rifampicin. Previously it was classified as Category IV under DOTS (DOTS-PLUS). The treatment is given in two phases, the intestive phase (IP) and the continuation phase (CP). The total duration of treatment for regimen for MDR-TB is 24-27 months, depending on the IP duration. o Treatment regimen comprises :- Intensive phase (6-9 months) : Six drugs : Kanamycin (Km), levofloxacin (Lvx), ethionamide (Eto), pyrazinamide (Z), ethambutol (E), and cycloserine (Cs). Continuation phase (18 months) : Four drugs : Levofloxaxcin, ethionamide, ethambutol and cycloserine. Total duration of treatment is 24-27 months. Treatment of extensive drug resistance (XDR) TB XDR-TB is defined as resistance to any fluoroquinolone and at least one of the following three second-line drugs (capreomycin, kanamycin, amikacin), in addition to multidrug resistance. The Regimen for XDR-TB would be of 24-30 months duration, with 6-12 months Intensive Phase (IP) and 18 months Continuation Phase (CP). Regimen is :- Intensive phase (6-12 months) : Seven drugs : Capreomycin, PAS, moxifloxacin, high dose INH, clofazimine, Linezolid, amoxyclay. Continuation phase (18 months) : Six drugs : PAS, moxifloxacin, high dose INH, clofazimine, linezolid, amoxyclay.
Total duration 24-27 months
Intensive phase - 6 drugs
Continutation phase - 2 drugs
Intensive phase 6-9 months