Which of the following local anaesthetic should not be alkalinized with soda bicarbonate
Local anaesthetic drug if dissociated –it wont act on sodium channel.
So drug is kept undissociated by adding soda bicarbonate to maintain pka 7.7→ 8.2
But for bupivacaine soda bicarbonate is not used as it gets precipitated.
Lignocaine
Procaine
Bupivacaine
Benzocaine