A patient presented with haematuria with acute renal failure. On doing renal biopsy, it showed cresentric glomerulonephritis. Immunofluoresence findings showed C3 & IgG deposition. Most likely diagnosis among the following is?
Answer- D. Acute post-infectious glomerulonephritisPSGN appears 1 to 4 weeks after infection of pharynx or skin by specific nephritogenic strains (12, 4 and 1) of group A beta hemolytic streptococci.The lesions are caused by Type III hypersensitivity reaction with immune complex deposition and complement activation, causing decreased complement level.Clinical features-HematuriaOliguria, Non-selective proteinuriaPSGN causes acute renal failure.By immunofluorescence microscopy, there are irregular granular deposits of IgG. IgM and C3 in the mesangium and along the basement membrane (starry sky appearance).
Membranous glomerulonephritis
Minimal change disease
Monoclonal deposition disease
Acute post-infectious glomerulonephritis