A female with recurrent aboion and isolated prolonged APTT is most likely associated with:
Miscarriages are more common in women with systemic lupus erythematosus. Many of these women have antiphospholipid antibodies, which are a family of autoantibodies that bind to negatively charged phospholipids, phospholipids-binding proteins, or a combination of the two. A prolongation in the aPTT is observed that does not correct completely on mixing. Specialized testing such as the hexagonal phase phospholipid neutralization assay, the dilute Russell viper venom time, and platelet neutralization assays can confirm the presence of a lupus anticoagulant. Ref: (2010). Chapter 9. Aboion. In Cunningham F, Leveno K.J., Bloom S.L., Hauth J.C., Rouse D.J., Spong C.Y. (Eds), Williams Obstetrics, 23e.
Lupus anticoagulant
DIC
Von willebrand disease
Hemophilia