Major contribution to cachexia with advanced cancer-
Cachexia is not caused bu nutritional demands of the tumor. It is suspected that TNF produced by macrophages in response to tumor cells or by the tumor cells them self mediate cachexia. TNF mobilize fat from tissue stores and suppress appetite. ROBBINS
Clathrin
Histamine
Nutritional demands of cancer
Tumor-necrosis-factor (TNF)
General pathology