THEME AND FOCUS: GLYCOLYSIS Case Study: A 42-year-old man presented with symptoms of weakness, fatigue, shoness of breath, and dizziness. His hemoglobin level was less than 7 g/dl (normal for a male being greater than 13.5 g/dl). Red blood cells of the patient showed abnormally low level of lactate production. Heinz bodies were not found in PBF. Lead Question: Deficiency of which one of the following enzymes would be the most likely cause of this patient's anemia?
Pyruvate kinase deficiency would be most likely cause of patient's anemia | lactate production in the erythrocyte indicates a defect in glycolysis. Pyruvate kinase deficiency 2nd most common cause (after glucose 6-phosphate dehydrogenase deficiency) of enzyme deficiency related to hemolytic anemia. In G6PD deficiency - Heinz bodies
Phosphoglucose isomerase
G6PD
Pyruvate kinase
Hexokinase
Glycolysis