A 45 year old was given steroids after renal transplant. After 2 years he had difficulty in walking and pain in both hips. Which one of the following is most likely cause -
High dose coicosteroid & alcohol abuse are the commonest causes of avascular necrosis,the commonest site being femoral head.the mechanism is intravascular thrombosis-hyperlipidemia & fatty degeneration of liver;fat embolism give rise tocapillary endothelial damage,platelet aggregation & thrombosis. reference:Apleys,9th edition,page no104
Primary osteoahritis
Avascular necrosis
Tuberculosis
Aluminum toxicity
Avascular necrosis and osteochondroses