A 40 weeks pregnant developed postpaum hemorrhage due to uterine atony. Which of the following drug can be given to this patient to stop the bleeding?
Ergot alkaloids markedly increase the motor activity of the uterus. Although their capacity to induce sustained uterine tetany precludes their use in the induction or facilitation of labor, they are used to prevent or treat postpaum hemorrhage in normotensive women. In this setting, the preferred ergot alkaloids are ergonovine or its methyl analog methylergonovine (methergine). They are administered intramuscularly or intravenously, exhibit rapid onsets of action, and their effects persist for 45 minutes to 3 hours depending on the route of administration. Adverse effects include nausea and vomiting, elevated blood pressure, and decreased pain threshold requiring analgesia. Ref: Schimmer B.P., Parker K.L. (2011). Chapter 66. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.
Oxytocin
Methergine
Progesterone
Prostaglandins