The effect of thiopentone on the CNS is quickly terminated because of:
Thiopentone is a ultra sho acting barbiturates ,its action is terminated because of redistribution . thiopentone is highly lipid soluble ,after i.v injection consciousness is regained in 6-10 minutes due to redistribution ,while the ultimate disposal occurs by metabolism. Greater the lipid solubility of the drug ,faster is its redistribution. Ref: KD Tripathi 8th ed
Rapid metabolism in the CNS
Quick first-pass elimination
Redistribution
Rapid metabolism in systemic circulation
Central Nervous system