Thyroid hormone receptor which is predominantly expressed in CNS/Brain ?
Ans. is'c'i.e., b-1There are three forms of thyroid hormone receptor that are able to bind thyroid hormone.TR - alpha 1+ Widely expressed with high expression in cardiac and skeletal muscle.TR- beta 1-+ Predominantly expressed in brain, liver and kidney.TR- beta 2-+ Expression primarily limited to hypothalamus & pituitary.Fouh isotypes TR- alpha2, is also widely expressed but is unable to bind thyroid hormone.
a - 1
a - 2
b-1
b-2