In well fed state, the activity of Carnitine Palmitoyl Transferase-1 in outer mitochondrial membrane is inhibited by:
Ans. C. Malonyl-CoA(Ref Harper 31/e page 214)Fatty acid oxidation is inhibited in the well fed state because, CPT-I activity is low in fed state because of inhibition by malonyl-CoA, the initial intermediate in fatty acid synthesis formed by acetyl-CoA carboxylase.
Glucose
Acetyl-CoA
Malonyl-CoA
Pyruvate
Lipids