The primary direct stimulus for excitation of central chemoreceptors regulating ventilation is?
increased 11+/Ref: Ganong 23/e p627-629] The primary direct stimulus for central chemoreceptors is increased Ir concentration in the CSF and brain interstitial fluid. (But the H+ conc. in the brain parallels the aerial PCO2 and not aerial H+ conc.) There are 2 types of chemoreceptors regulating ventilation: central chemoreceptors (located in brain stem, mainly medulla) and the peripheral chemoreceptors (aoic and carotid bodies). They regulate ventilation by resonding to increased aerial H+ conc., increased PaCO2, and decreased Pa02. Thus the peripheral chemoreceptors are stimulated by hypoxia, hypercapnia, and acidemia to cause hyperventilation; whereas central chemoreceptors are stimulated only by hypercapnia. Why the central chemoreceptors respond to blood PaCO2 and not to blood H+ cone?. Even though the central chemoreceptors are directly stimulated by H+ ions: the blood H+ ions are poorly permeable through the blood brain barrier and hence are not able to regulate ventilation through the central chemoreceptors. Whereas CO2 is highly permeable to the blood brain barrier. It enters the brain, where it is hydrated to give rise to H+ and HCO3- ions. Now these H+ ions directly stimulate the central chemoreceptors to regulate the ventilation. So the central chemoreceptors respond to changes in H+ ions in the cerebrospinal fluid and brain interstial which are brought about by changes in aerial PaCO2. Remember: The link between metabolism and ventilation is CO2 and not 02.
>Increased ft
>Increased CO2
>Increased 02
>Decreased CO2