Bleeding disorders with ↑ APTT and ↑PT:a) Factor 13 deficiencyb) Severe liver diseasec) Immune thrombocytopenic purpurad) Leiden (Factor V) deficiency
Prothrombin time assesses factor V, VII, X & II ; all of which are synthesized in liver.
PTT assess measures activity of factor V, VIII, IX, X, XI, XII & II some of which (II, VIII, VII, X, V) are synthesized in liver.
So, in liver diseases both aPTT as well as PT are increased.
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