True about glycolysis are all except ?
Ans. is 'c' i.e., Two carbon end product is formed Impoant facts about glycolysis An impoant biochemical significance is the ability of glycolysis to provide ATP in the absence of oxygen (anerobic glycolysis) and allows tissues to survive anoxic episodes. It occurs in cytosol 3 Carbon atoms end product (pyruvate or lactate) is produced. Irreversible steps are catalyzed by : - Glucokinase/Hexokinase, phosphofructohnase-I, and pyruvate kinase. Reversible steps are catalyzed by : - Phosphohexose isomerase, aldolase, phosphotriose isomerase, glyceraldehyde 3-phosphate dehydrogenase, Phosphoglycerate kinase, Phosphoglycerate mutase, Enolase. Energy (ATP) using steps are catalyzee by : - Hexokinase/glucokinase, phosphofurctokinase. Energy (ATP) production at substrate level are catalyzed by : Phosphoglycerate kinase, Pyruvate kinase. Reducing equivalent (NADH) production is catalyzed by : Glyceraldehyde 3-phosphate dehydrogenase. Cancer cells derive nutrition from glycolysis as they have lack of 02 supply because of lack of capillary network. Glycolysis (anaerobic glycolysis) is the only metabolic pathway in the body which can provide energy by glucose metabolism in anerobic conditions.
Provide nutrition to cancer cells
Substrate level phosphorylation at pyruvate kinase
Two carbon end product is formed
NADPH is formed by glyceraldhyde-3-phosphate dehydrogenase