Sensitivity of chemoreceptors in COPD
The main chemoreceptors involved in respiratory feedback are: Central chemoreceptors: These are located on the ventrolateral surface of medulla oblongata and detect changes in the pH of spinal fluid. They can be desensitized over time from chronic hypoxia (oxygen deficiency) and increased carbon dioxide Ref: guyton and hall textbook of medical physiology 12 edition page number:365,366,367
Decreased to H+
Increased to H+
Increased to PCO2
Increased to PO2
Respiratory system