If carbamazepine is added to valproate, which side effect of valproate can increase?
Valproate is metabolized by cytochrome P450 and produce a metabolite which is hepatotoxic Carbamazepine is enzyme inducer which cause the induction of its metabolism and produce more metabolite, thus causing hepatotoxicity
Thrombocytopenia
Hepatotoxicity
Hyperammonemia
Pancreatitis
Epilepsy