Veepofrin Dye is used in:
Veepofrin dye is used in photodynamic therapy. Photo Dynamic Therapy Choroidal Neo Vascular (CNV) membrane secondary to wet ARMD. New or recurrent subfoveal CNV Predominantly classic Lesion <5400 in Greatest Linear Diameter Primary ocular histoplasmosis syndrome. Pathological Myopia. Photodynamic therapy (concept) Involves injection of photosensitizing drug Two step, out patient procedure , I/V photo active drug | Complexes with LDL present in blood | Complex accumulates in choroidal neovascular lesions |After 15 minutes of IV inj. Activation of drug by non thermal (689nm) light in presence of oxygen | Formation of free radicals-cytotoxic, Singlet oxygen species | | Platelet activation Direct cytotoxicity | Neo-vasculature thrombosis Photodynamic therapy: Technique (PGI potential question) Photosensitising dye (Veeporfin) 6 mg/m2 BSA (30 ml) I.V. over 10 minutes. Diode laser at 689 nm, Slit lamp delivery system designed to deliver 50 J/cm2 Intensity of 600 mW /cm2 Over 83 seconds, Advantages High selectivity and no to minimal collateral damage. Temperature rise is only 2 degrees. Minimal side effects: Infusion related back pain. Extravasation and phototoxic reactions Visual disturbances, eye pain, RPE tears Visual field defects. Disadvantages Expensive Protective clothing/eye protection after treatment for five days.
Fluoresceina Angiography
Indocyanin Angiography
Photodynamic therapy
All
Diagnosis and Treatment of Retina