In which of the following disorders, administration of barbiturates is contraindicated?
Ans. (B) Acute intermittent porphyria(Ref: KDT 8/e p427)Barbiturates induce the rate limiting enzyme 'd-aminolaevulanic acid synthase' in porphyrin synthesis. This increased synthesis of porphyrins can precipitate acute attack of AIP.
Anxiety disorders
Acute intermittent porphyria
Kernicterus
Refractory status epilepticus
Seedatives & Hyponotics