Pethidine should not be given with -
Ans. is `d' i.e., MAO inhibitors o MAO inhibitors inhibit hydrolysis but not detmethylation --> more norpethidine is produced. Hydrolysis Mepridinic acid (major metabolic) Pethidine Dernekiation Norpethidine (minor metabolite) o MAO inhibitors selectively inhibit its hydrolysis without effecting demethylation -4 Accumulation of norpethidine --> Excitement.
Reserpine
Propranolol
Atenolol
MAO inhibitors