Down regulation of hormone means ?
Ans. is 'b' i.e., Decreased affinity to receptors Down regulation is a mechanism in which a hormone decrease the number or affinity of its receptors in target tissues. Down-regulation may occur by decreasing the synthesis of new receptors, by increasing the degradation of existing receptors or by inactivating receptors. The purpose of down-regulation is to reduce the sensitivity of the target tissue when hormone levels are high for an extended period of time.
Decreased secretion of hormone
Decreased affinity to receptors
Defective regulation in secretion
Regulation by low concentration of hormone