Which of the following antineoplastic agents is used in the management of Hodgkins lymphoma, non Hodgkins lymphoma and small cell carcinoma of lung?
Ans. is 'a' i.e., Cisplatin * Out of the antineoplastic agents mentioned in the choices Cisplatin is used in the management of Hodgkins lymphoma, non Hodgkins lymphoma and small cell carcinoma of lung.a) Cisplatin in combination with etoposide or irinotecan is used in management of small cell carcinoma of lung.Optinal first line chemotherapy regimen according to histological typeHistologyChemotherapyPreferred drug to b combined with plantnum compoundTargeted agent in combination with chemotherapy CetuximabBevacizumabNSCLCPlantnum based doublet3rd generation drugt * Squamous cell* Adenocarcoma* Large cell* Undifferentilated All except pematrexedPematrexedPemetrexedAll except pemetrexedYesYesYesYesNoYesYesYesSCLCPlatnum based doubletEtoposide or irinotecanNoNoMalignant carcinoidPlantnum based doubletEtoposide or irinotecanNoNoPlatinum based doublet consists of a platinum agent (commonly cispatin or carboplatin) with another drug, | Commonly used third-generation chemotheraputic agent include gemcitabone, docataxel, pactixel, pemetrexed and vinorebinePatent with high epidermal growth factor receptor gene copy number determined by florescent in-situ hybridization testing NSCLC: Non-small cell lung cancer, SCLC = Small cell lung cancer.b) Cisplatin is used as a continuous intravenous infusion over 24hours for management of Hodgkins lymphoma in the following regimeDrugDoseRouteScheduleDHAPDexamethasone40 mgi.v.Days 1-1Cytrabine2 mg/m2 q12hr (2 doses)i.v. (3 hr)Day 2Cisplatin100 mg/ nrCIVI (24 hr)Day 1Repeat every 21 to 28 daysCIVI. continuous intravenous infusion c) For Non Hodgkins lymphoma Cisplatin is used as a second line therapy in the following regimeSecond-line Therapy (for patients with intention to proceed to high-dose therapy)DHAP +- rituximabDays 1-4: Cisplatin 100mg/m1 IV via 24-hour infusion + cytosine 2g/m2 in 2 pulses each given 12 hours apart IV + dexamethasone 40mg orally or IV +- rituximab 375mg/m2 IV prior to DHAP. Repeat in 3-4 weeks for 6-10 cycles.
Cisplatin
Bleomycin
Paclitaxel
Doxorubicin
Oncology