An inhibitor was designed to block a biologic function in H. influenzae. If the goal of the experiment were to reduce the virulence of H. influenzae, the most likely target would be
The major determinant of virulence in H. influenzae is the presence of a capsule. There is no demonstrable exotoxin and the role of endotoxin is unclear. While one would expect that IgA protease would inhibit local immunity, the role of this enzyme in pathogenesis is yet unclear.
Exotoxin liberator
Endotoxin assembly
Flagella synthesis
Capsule formation
Systemic Bacteriology (Haemophilus, Yersinia, Spirochaetes, Ricketssia, Chlamydia, Mycoplasma and Miscellaneous Bacteria)