What is involved in formation of d-TMP from d-UMP: (PGI June 2007)
Ans: A (N5, N10, Methylene tetrahydrofolate) Lippincott 4th/303-04: SaysdUMP is converted to dTMP by thymidylate synthase, which uses N5;N10'-methylene tetrahydrofoiate Q as the source of the methyl group. This is u nasal reaction in that tetrahydrofoiate {THF) contributes not only a one carbon unit but also fwo hydrogen atoms from the pteridine ring, resulting in the oxidation of THF to dihydrofolate (DHFJ.Inhibitors of thymidylate syn those includes thymine a nalogs such as 5-fluroruracil(DHF) can be reduced to THF by dihvdrofolate reductaseQ an enzyme that is inhibited in the presence of drugs such as methotrexateQ
N5, N10- methylene tetra hydrofolate
Form imino folate
N5 formyl folate
Dihydro folate
Chemistry of Nucleotides 