A child with acute myeloid leukemia presents with hyperleukocytosis. Treatment includes all of the following EXCEPT:
Hyperleukocytosis: - Leukocyte count > 100,000/uL - It is medical emergency most commonly seen with AML or CML in blast crisis - There is sludging of blasts in microcirculation - obstruction of small vessels especially in brain & lungs - Treatment: IV fluids (hydration) Alkalinization Allopurinol (to prevent tumor lysis syndrome) Hydroxyurea (for leukoreduction) - Induction chemotherapy- initiated only after leukoreduction, as it carries a high-risk of acute tumor lysis syndrome
IV fluid
Allopurinol
Alkalinization
Immediately sta induction chemotherapy
Neoplastic disorders of WBCs