Major form of folic acid to transfer one carbon is
The folic acid is first reduced to 7,8-dihydrofolic acid and fuher reduced to 5,6,7,8-tetrahydrofolic acid (THFA) (Fig. 34.17). Both reactions are catalyzed by NADPH dependent folate reductase. B. TThe folic acid is first reduced to 7,8-dihydrofolic acid and fuher reduced to 5,6,7,8-tetrahydrofolic acid (THFA) (Fig. 34.17). Both reactions are catalyzed by NADPH dependent folate reductase.The THFA is the carrier of one-carbon groups. One carbon compound is an organic molecule that contains only a single carbon atom. The following groups are one carbon compounds: i. Formyl (-CHO) ii. Formimino (-CH=NH) iii. Methenyl (-CH=) iv. Methylene (-CH2-) v. Hydroxymethyl (-CH2OH) vi. Methyl (-CH3).he THFA is the carrier of one-carbon groups. One carbon compound is an organic molecule that contains only a single carbon atom. The following groups are one carbon compounds: i. Formyl (-CHO) ii. Formimino (-CH=NH) iii. Methenyl (-CH=) iv. Methylene (-CH2-) v. Hydroxymethyl (-CH2OH) vi. Methyl (-CH3).Ref: DM Vasudevan - Textbook of Biochemistry, 6th edition, page no: 401
Methylene THF
Formyl THF
Methyl THF
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vitamins