Which of the following statements about imipenem is most accurate?
Carbapenems are synthetic b-lactam antibiotics Imipenem, meropenem, doripenem and eapenem are the drugs of this group currently available. Imipenem : Effective against : Gm +ve, Gm -ve including pseudomonas and anaerobic. Dehydropeptidase by kidney metabolises imipenem rapidly. Cilastatin is a dehydropetidase inhibitor, which must be given along with imipenem for desired action. Side effect : Seizure
The drug has a narrow spectrum of antibacterial action
It is used in fixed dose combination with sulbactum
In renal dysfunction, dosage reductions are necessary to avoid seizures
Imipenem is active against methicillin-resistant staphylococci
Cell Wall Synthesis Inhibitors