The mechanism of anti cancer action of fluoruracil is
5-FU is an antimetabolite.it us a thymidine analogue and acts by conversion to 5'-dUMP .latter inhibits the formation of dTMP and result in Thymineless dealth of cells Ref-KDT 6/824
Cross linking of double standard DNA and the resulting inhibition of DNA replication and transcription
Cytotoxicity resulting from metabolite that interferes with the production of dTMP
Irreversible inhibition of dihydrofolic acid reductase
Selective action of DNA polymerase
Other topics and Adverse effects