Which one of the following is the most significant risk factor for the development of gastric carcinoma?
" The risk of tumor development is greatly increased in patients in whom mucosal inflammation progresses to multifocal mucosal atrophy and intestinal metaplasia"- Robbins
"Serial endoscopic examinations of the stomach in patients with atrophic gastritis have documented replacement of the usual gastric mucosa by intestinal-type cells. This process of intestinal metaplasia may lead to cellular atypia and eventual neoplasia" - Harrison
Paneth cell metaplasia
Pyloric metaplasia
Intestinal metaplasia
Ciliated metaplasia