All are typical electron microscopic features of Alpo syndrome, EXCEPT:
Typical electron microscopic changes in Alpo syndrome: 1. Irregular thickening of the GBM of up to 4 or 5 times the normal thickness, 2. Multi Lamellation of the lamina densa forming a "basket weave" pattern by inclusion of electron lucent areas, often containing round, dense granules, measuring 20-60 nm in diameter. The earliest manifestation of the GBM is irregular thinning, and the extent and severity of thickening and multi lamellation increases with age. These changes are often widespread especially in adults. Ref: Dan Med Bull 2009; 56:105-52.
Irregular thickening of GBM
Multi Lamellation of the lamina densa
Basket weave pattern of lamina densa
Thickening of the renal tubules