Glyceryl trinitrate is given by sublingual route, because it has
Glyceryl trinitrate (GTN) has high first pass metabolism. So preferred route is sublingual to bypass the metabolism liver Advantage of sublingual route Fast acting No first pass metabolism Self administration is possible After action drug can be spitted out
High absorption
High first pass metabolism
Low volume of distribution
High plasma protein bound
CHF, Angina Pectoris and Myocardial Infarction