TRUE statement about histopathological changes noticed in Wilson's disease is:
Histopathological changes are not specific for Wilson's disease. MUST KNOW: The earliest change is steatosis followed by peripoal glycogenated nuclei. Copper is not biochemically identifiable at this stage. Mallory denk bodies in zone 1 is a characteristic but not pathognomic finding of Wilson's disease. Absence of stainable copper in cirrhotic specimen does not rule out Wilson's disease. Macronodular cirrhosis is the most common cirrhosis noticed in wilson. Sometimes macronodular along with micronodular also noticed. Ref: Schiff's disease of liver, Edition-11, Page-811.
Mallory denk bodies in Zone 1 is a pathognomic finding
Earliest change noticed is copper deposition in mitochondria
Micronodular cirrhosis is also noticed
Absece of stainable copper in cirrhotic liver does not rule out Wilson's disease.