The coagulation profile in a 13 year old girl with Menorrhagia having von Willebrands disease is:
- Von Willebrand factor acts as a plasma carrier of factor VIII and circulates in blood as factor VIII-VWF complex. - Thus, VWF deficiency impairs intrinsic pathway of coagulation & prolongs aPTT - Extrinsic pathway of coagulation remains unimpaired, PT is not altered.
Isolated prolonged aPTT with a normal PT
Isolated prolonged PT with a normal aPTT
Prolongation of both PT and aPTT
Prolongation of thrombin time
Coagulation disorders