led maternal serum a-FP is seen in :
Ans. is b i.e. Trisomy 21 Low levels of MSAFP (Maternal serum alpha feto protein) are seen in : Chromosomal trisomy Gestational trophoblastic diseases Blighted ovum Increased maternal weight Overestimated gestational age. Note : The list given in the Williams Obs. 23/e, p 291 - Includes fetal death both in causes of increased and decreased AFP. But Fernando Arias 2/e, p 38 specifically includes - IUD in the causes of increased AFP and Blighted ovum /Aboion in the causes of decreased AFP.
Multiple pregnancy
Trisomy 21
Open neural tube defect
IUD