In blood buffers Bicarbonates buffers is ideal why?
(High concentration): (711-/2- Shinde 8th edition)Bicarbonate Buffer system* Consists of weak acid "Carbonic acid" (H2CO3) and strong base (HCO3), NaHCO3 (Sodium bicarbonate)* Normal ratio in blood =NaHCO3H2CO3=201* They are the chief buffers of blood and constitute the so called Alkali reserve* Neutralisation of strong and non volatile acids entering the ECF is achieved by the bicarbonate buffers* Bicarbonate buffer system is directly linked up with respiration* Bicarbonate buffers system serve as an index to understand the disturbance in the acid base balance of the body (476- U. Satyanarayan 4th)Advantages of bicarbonate buffer system* It is present in very high concentration than other buffer system (26 to 28 millimole per littre )* Produces H2CO3 which is weak acid and volatile and CO2 is exhaled out* Hence it is a very good physiological buffer and acts as a front line defense.Disadvantages - As a chemical buffer, it is rather weak, pKa is further away from the physiological pH
Pka is equal to Ph
High concentration
Weak acid and weak base combination
easy to measure
Miscellaneous (Bio-Chemistry)