Propofol causes pain on injection. True is all except
All phenols irritate skin and mucous membrane. Thus, propofol being an alkylphenol is expected to cause pain in spite of the fact that it is almost isotonic. Pain on propofol injection has also been described as angialgia by some meaning that the pain is due to vascular involvement. Pain on propofol injectionis immediate as well as delayed after 10-20 s. The immediate pain is due to irritation of vein endothelium whereas delayed pain is due to the release of mediators such a kininogen from kinin cascade.
It is kallikerein pathway mediated
It is due to 1-2% egg lecithin component as it causes crystalization in the veins
Can be reduced by adding 1% lignocaine in the syringe
Use of larger veins decreases the incidence
Intravenous Anesthetic Agents