Which of the following is the first line drug for follicle induction in infeility in PCOS
Letrozole is the Drug of choice- Induction of ovulation in a case of PCOS; Mode of action- Aromatase Inhibitor Decrease Estrogen production-->Inhibit Negative feedback on FSH --> increases FSH --> increase stimulation of follicles Letrozole preferred over Clomiphene citrate because decreases chances of multifetal pregnancy increased live bih rate OHSS : Rare with it Given for 5 days (D5-D9) Sta with 2.5mg Max dose 7.5mg
Clomiphene citrate
GnRH agonist
Combined oral Pills
Letrozole
Polycystic Ovarian Syndrome