Which of the following renal alterations would most likely preserve the GFR?
The renal alteration that would most likely preserve the GRF is type I distal renal tubular acidosis, in which hydrogen ions diffuse back into the distal tubule. This not only retains hydrogen ions, but also reduces the distal tubule reabsorption of bicarbonate. The other choices listed are assocated with acute tubular necrosis and decrease the GFR.
Defect in the elimination of hydrogen ions in the distal tubule
Luminal obstruction by renal tubular casts
Increased interstitial pressure
Decreased intrarenal nitric oxide
Renal physiology