Which of the following is true about gastrointestinal carcinoid tumor?
Answer- D. Preoperative octreotide scanning can detect extent of the diseaseThese neuroendocrine tumours occur throughout the gastrointestinal tract, most commonly in the appendix, ileum and rectum in decreasing order of frequency. Appendicular carcinoid tumours are most commonly noted as an incidental finding at appendicectomy.Carcinoid tumours arise from Kulchitsky cells at the base of intestinal crypts (of Lieberkuhn)The tumours can produce a number of vasoactive peptides, most commonly S-hydroxytryptamine (serotonin), but also histamine, prostaglandins and kallikrein.Classically, the flushing attack are induced by alcohol.The extent of disease can be assessed preoperatively using octreotide scanning, which may detect otheise clinically apparent primary and secondary tumour.
Alcohol has no effect on the flushing attacks
Occur most commonly in jejunum
Tumors most commonly produce histamine
Preoperative octreotide scanning can detect extent of the disease