All of the following are propeies of local anesthetics EXCEPT:
- Local anesthetic receptor is located within the channel in its intracellular half. - LA traverses the membrane in unionized form. - LAs act from within the neuron and are more active when the neuron is rapidly firing (i.e., Na+ channels are open). so it doesnot act in resting form.
Blockade of voltage dependent Na+ channels
Preferential binding to resting channels
Slowing of axonal impulse conduction
Increase in the membrane refractory period
Anaesthesia