True statement about fexofenadine is:
Fexofenadine is an active metabolite of terfenadine. It lacks K+ channel blocking propey, therefore is devoid of arrhythmogenic potential. It is available as a separate second generation H1 blocking agent.
It undergoes high first pass metabolism in liver
Terfenadine is an active metabolite of this drug
It does not block cardiac K+ channels
It has high affinity for central H1 receptors
Histamine, 5-HT and PGs