A 20 year old male presents with chronic constipation, head ache and habitus, neuromas of tongue, medullated corneal nerve fibers and nodule of 2*2 cm size in left lobe of thyroid. This patient is a case of:
MEN-2A (Sipple Syndrome MEN) MEN-2B (MEN-3) Components Medullary carcinoma thyroid Pheochromocytoma Parathyroid hyperplasia or adenoma Hirschprung&;s Disease Cutaneous lichen amyloidosis Medullary carcinoma thyroid Pheochromocytoma Intestinal ganglioneuromas Mucosal neuromas Megacolon Marfanoid features Defect RET oncogenic (Cysteine codon) Chromosome: 10 RET oncogene (tyrosine kinase domain) Chromosome: 10 Transmission Autosomal dominant Autosomal Dominant Ref: Sabiston 20th edition Pgno: 993,1003
Sporadic medullary carcinoma of thyroid
Familial medullary carcinoma of thyroid
MEN-2A
MEN-2B
Endocrinology and breast