The following acute respiratory response to ascent to high altitude, there is normalization of blood pH. The mechanism is
The lung response to acute altitude exposure is mainly hyperventilation which, together with elevated hea rate, aims at achieving an adequate supply of oxygen to the tissues. At rest, ventilation increases by firstly increasing the tidal volume, at least up to 3500 m. Ref: guyton and hall textbook of medical physiology 12 edition page number:365,376,377
Increased erythropoesis leads to increased buffering by hemoglobin
Increased excretion of HCO3 - by the kidneys
Increased levels of 2, 3--DPG
Retention of bicarbonate by the kidneys
Respiratory system