Normal stature with minimal or absent pubeal development may be seen in:
Testicular feminization is a syndrome of androgen insensitivity, characterized by a normal 46 XY genotype; normal female phenotype during childhood; tall stature; and "normal" breast development with absence of axillary and pubic hair. Gonadal dysgenesis (e.g., 45X Turner syndrome) is characterized by sho stature and absence of pubeal development; in these girls, the ovaries are either absent or streak gonads that are non-functional. Kallmann syndrome (hypogonadotropic hypogonadism) should be suspected in patients of normal stature with delayed or absent pubeal development, especially when associated with the classic finding of anosmia. These individuals have a structural defect of the CNS involving the hypothalamus and the olfactory bulbs. The hypothalamus does not secrete GnRH in normal pulsatile fashion, if at all.
Testicular feminization
Kallmann syndrome
Pure gonadal dysgenesis
Turner syndrome
Pubeal Changes