Which of the following drug is associated with the highest cardiac moality?
Coxibs are selective cox2 inhibitors- Basically, Coxibs are NSAIDS They won't cause gastric acidity as they won't exe their effect on cox-1 but as there is an increased chance of cardiac events like hea attack due to excess thrombosis Excess thrombosis is due to decrease in PGI2 and enhanced TXA2 Ref: KD Tripathi 8th ed.
Rofecoxib
Nicorandil
Losaan
Metoprolol
Cardiovascular system