Microangiopathic Hemolytic anemia is seen in all Except:
Answer is None or B (None or Metallic Hea Valve) `Metallic hea valves' is the single best answer of exclusion. Pathologically Prosthetic Hea valves are associated with macroangiopathic hemolytic anemias and not microangiopathic hemolytic anemias. TTP, Antiphospholipid syndrome, vasculitis syndromes (including MPA) and mechanical hea valves may all give rise to hemolytic anemia due to red cell fragmentation. Most textbooks do not make a distinction between macroangiopathic and microangiopathic hemolytic syndromes and club all causes into the category of microangiopathic hemolytic anemias (including prosthetic valve hemolytic anemias) However in strict terminology microangippathic hemolytic anemias result from cell fragmentation that occurs in the microcirculation. Red cell fragmentation hemolytic anemias from prosthetic hea valves is strictly/pathologically a macroangiopathic hemolytic anemia and hence the single best answer of exclusion.
TTP
Metallic hea valve
Microscopic polyangitis
Anti-phospholipid syndrome