Regarding ACE inhibitor which of the following is true?
Ans. is 'c' i.e., Omiting the diuretic dose helps in reducing first dose hypotension If patient is on diuretics, omission of prior diuretic dose decreases the risk of postural hypotension. About other options o ACE inhibitors inhibit the conversion of angiotension Ito angiotension II. o Half life of enalapril is only 1.3 hour, while lisinopril has a half life of 12 hours. o Although the role of ACE inhibitors in left ventricular systolic dysfunction is firmly established whether these drug improve diastolic dysfunction is an impoant open question. Infusion of enalaprilat into left coronary aeries of patients with left ventricular hyperophy significantly improves diastolic function.
Inhibits conversion of angiotensinogen to angiotensin 1
T1/2 of enalapril is more than lisinopril
Omiting the diuretic dose helps in reducing first dose hypotension
It is effective only with left ventricular systolic dysfunction