Endothelium activation refers to -
Ans. is 'd' i.e., Increased expression of adhesion molecules for leukocyte recruitment o Vascular endothelium in its normal, unactivated state does not bind circulating cells or impede their passage,o In acute inflammation, the endothelium is activated and can bind leukocytes as a prelude to their exit from the bloodvessels.o Inflammatory mediators like thrombin, IL - 1, Platelet Activating Factor, Histamine And TNFactivate endothelial cells by increasing expression of adhesion molecules which can bind leukocytes for leukocyte recruitment.
Aberration of anatomy of vessel wall
Irreversible changes in functional state of vessel wall
Smooth muscle proliferation
Increased expression of adhesion molecules for leukocyte recruitment
Miscellaneous (Blood Vessels)