Most immunogenic RBC blood group system out of the given options is:-
Most immunogenic RBC blood group system:- ABO Blood Grouping > Rh> Kell. If there is mismatch b/w two individual on differential expression of the Kell ag, this can be responsible for Hemolytic diseases of new born (HDN) Duffy Receptor/Ag on RBC which facilitate the entry of plasmodium vivax. Therefore, those individual with Duffy negative RBC are resistant to plasmodium vivax Malaria.
Kell
Duffy
Kidd
Lewis antigen
Hematopoeisis: Basic concepts