All of the following are true regarding penicillin except: March 2005
Ans. A: Probenecid decreases it duration of action Drug interactions have been deliberately used to prolong the effect of penicillin, such as co-administering probenecid with penicillin prior to mass production of penicillin. Because penicillin was difficult to manufacture, it was wohwhile to find a way to reduce the amount required. Probenecid retards the excretion of penicillin, so a dose of penicillin persists longer when taken with it and it allowed patients to take less penicillin over a course of therapy.
Probenecid decreases it duration of action
All penicillin are active against gram positive organisms
Splits into 6-amino penicillanic acid by amidase
Acts by inhibiting cell wall synthesis