Pyruvate utilisation is decreased in:
PDH complex requires five coenzymes - Vitamin B1, B2, B3, B5 and Lipoic acid. Vitamin B1 deficiency - Beri-beri Beri- beri - |PDH activity - | pyruvate to acetyl-CoA conversion - low pyruvate utilization Vitamins (B1, B2, B3, B5) - decreased energy production and CNS problems (brain cells depend upon this aerobic reaction)
Pernicious anemia
Scurvy
Folate trap
Beri-beri
Link reaction