SMAC/DIABLO is a
Diablo homolog (DIABLO) is a mitochondrial proteinthat in humans is encoded by the DIABLO (direct IAPbinding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, ref Robbins 9/e p 19, and internet
Anti apoptotic protein
Induces necrosis
Acts both as anti and pro apoptotic protein
Pro-apoptotic protein
General pathology