Which of the following is false regarding Multiple Sclerosis (MS)?
Multiple sclerosis is an auto immune disease of central neural system with a relapsing and remitting or progressive course. The pathologic hallmark of disease is demyelination. Myelin specific antibodies are present on degenerating myelin sheaths. Surviving oligodendrocytes paially remyelinate surviving axons, which are called as shadow plaques. Reference: Harrison's Principles of Internal Medicine, 21st edition, p2661
More common in women and age of onset is between 20-40 years of age
Risk factors include vitamin D deficiency and cigarette smoking
Pathological hallmark is axonal degeneration
HLA DRB1 in MHC class II is associated with 10% of disease risk
All India exam