Which of the following is a feature of a highly ionized drug?
A highly ionized drug is lipid insoluble, it is therefore not reabsorbed across the renal epithelial membrane and is easily excreted by the kidneys. Non Ionized Drugs Ionized Drugs Non ionized drugs are lipid soluble Ionized drugs are lipid insoluble Rapidly pass across placenta Poorly pass across placenta Rapidly absorbed from stomach & intestine Poorly absorbed from stomach & intestine Ref: Nutrition Therapy and Pathophysiology By Marcia Nahikian Nelms, Page 303; Small Animal Clinical Pharmacology By Jill E. Maddiso, Page 34
Accumulates in the cellular lipids
Can cross the placental barrier easily
Is well absorbed from the intestine
Is excreted mainly by the kidney