The diagnostic criteria as proposed by FLINTER for Alpo syndrome has all the features, EXCEPT:
Diagnostic criteria for classical X-linked Alpo syndrome. At least three of the following four criteria must be fulfilled for a diagnosis of Alpo syndrome to be made clinically: In a patient with microscopic hematuria A positive family history of hematuria with or without chronic renal failure. Typical ultrastructural GBM changes in a renal biopsy specimen. High-tone sensorineural deafness. Characteristic ophthalmological signs (lenticonus and/or macular flecks) Ref: Dan Med Bull 2009; 56:105-52
Positive family history
Typical changes in renal biopsy specimen
High tone sensorineural deafness
Cardiovascular changes