Following acute respiratory response to ascent to high altitude, there is normalization of blood pH.The mechanism is
Decrease in PaO2 stimulates the peripheral chemoreceptors at high altitudes. This triggers hyperventilation. Hyperventilation results in CO2 washout and respiratory alkalosis. This is compensated by increased excretion of bicarbonates by the kidney.
Increased erythropoiesis leads to increased buffering by haemoglobin
Increased excretion of HCO3– by the kidneys
Increased levels of 2, 3–DPG
Retention of bicarbonate by the kidneys