Eosinophilia in necrosed tissue is due to ?
Necrotic cells show increased eosinophilia in hematoxylin and eosin (H & E) stains. It is mainly due to these 2 Factors Loss of cytoplasmic RNA (or ribonucleoprotein/RNP) which binds the blue dye, hematoxylin. Denatured cytoplasmic proteins which bind the red dye, eosin.
Coagulation of proteins
Denaturation of enzymes
Denaturation of protein
Mitochondrial damage