Which of the following statement is not true about NSAIDs
Acetylsalicylic acid (asprin) is an Irreversible inhibition of COX enzyme. IT results in inhibition of prostaglandin and TX synthesis at low doses for (40 to 325 milligrams) it exes antiplatelet action. this drug shows saturation kinetics at high doses that is kinetics changes from first order to zero order. therefore at high doses amount of drug exeed will be constant that means clearance il is not constant. Refer kDT 6/e p185
Acetylsalicylic acid is an Irreversible inhibitors of Cox enzyme acetylsalicylic acid is an Irreversible inhibitors of Cox enzyme
Acetylsalicylic acid reduces in Vivo synthesis of prostaglandins
Its clearance is independent of Plasma concentration
Antiplatelet effect of low dose aspirin is related to pre systemic Cox inhibition
Autacoids