A person presents with fever and altered consciousness. Investigations reveal anemia with fragmented red blood cells, platelet count of 20,000/mm', serum creatinine of 3.0 mg % and normal PT and aPTT. Which of the following is the most appropriate treatment for the patient:
Answer is A (Plasma Exchange Therapy): Plasma Exchange Therapy is the treatment of choice for TTP Pentad of Fever, Microangiopathic Hemolytic Anemia, Thrombocytopenia (platelets count = 20,000), Renal Failure (I'verum creatinine) and Neurological dysfunction (altered consciousness) together with normal tests of coagulation (normal PT and aPTT) confirms a diagnosis of Thrombotic Thrombocytopenic Purpura. Plasma Exchange .forms the mainstay of treatment of TTP. 'Plasma Exchange remains the mainstay of treatment of TTP'
Plasma Exchange Therapy
Coicosteroids and Intravenous
Immunoglobulins
Anticoagulation with Heparin