Which is a prodrug ?
Enalapril Remember, The end result of drug metabolism is usually the abolition of activity of the drugs and conversion of drug from lipid soluble to water soluble compounds but sometimes the drug may be conveed from its inactive form to active form. Prodrugs Few drugs are inactive as such and need conversion in the body to one or more active metabolites. Such a drug is called a prodrug. The prodrug may offer advantage over the active form in being more stable, having better bioavailability or other desirable pharmaco-kinetic propeies or less side effects and toxicity. Prodrug Active form * Levodopa Dopamine * Enalapril Enalaprilat * S-methyldopa a methylnorepinephrine * Dipivefrine Epinephrine * Sulindac Sulfide metabolites * Hydrazide MAO Hydrazine derivatives inhibitors * Proguanil Proguanil triazine * Prednisone Prednisolone * Becampicillin Ampicillin * Sulfasalazine 5 Aminosalicyclic acid * Cyclophosphamide Aldophosphamide, Phosphoramide mustard * Fluorouracil Flourouridine monophosphate * Mercaptopurine Methylmercaptopurine ribonucleotide
Enalapril
Clonidine
Salmeterol
Acetazolamide