All are true about HMG CoA reductase inhibitors EXCEPT:
Ans. is 'd' Fibrinogen levels are increased by pravastatin Fibrinogen levels are not increase but decreased by Pravastatin.Other optionOption A * Simvastatin and Lovastatin are lipophilic drugs therefore their CNS penetration is more than pravastatin and fluvastatin which are hydrophilic drugs.Option BSimvastatin undergoes rapid first pass metabolism. In fact all the statins (including Pravastatin) undergo rapid first pass metabolism.I am not very clear what the examiner actually means by the term "metabolized" in this option, but read the below quoted lines from Goodman Gilman-"Pravastatin is excreted without extensive metabolic modification".This line gives some satisfaction that this option may be true.Option CAbsorption of the statins is enhanced by taking the dose with food, except for Pravastatin whose absorption is only minimally affected.Also knowLovastatin and simvastatin are prodrugs *Adverse effect of HMG Co red inhibitorsMuscle tenderness and rise in CPK levels.Myopathy, though rare but more common when statins are given along withErythromycin*Nicotinic acid*Gemfibrozil*Cyclosporine*Mnemonic : ENG College
The CNS accumulation of simvastatin and lovastatin is high and less for provastatin and fluvastatin
Simvastatin is rapidly metabolised and provastatin is least
Bioavailability is minimally modified when provastatin is taken with food
Fibrinogen levels are increased by provastatin
Hypolipidemic