Postmortem lung specimen of a patient who developed severe respiratory distress and petechiae after fracture of shaft of femur is given below. All are true about the condition given below EXCEPT?
Ref: Pocket Companion to Robbins, 9th ed. pg. 79* The image shows lung specimen stained with Oil Red O stain and clinical history is consistent with fat embolism.* Non-cardiogenic pulmonary edema is seen with ARDS and not fat embolism.* In contrast the development of fat embolism is due to a series of biochemical cascades resulting from the mechanical insult sustained in major trauma. Release of fat emboli leads to occlusion of the microvasculature.* Findings from non-contrast computed tomography (CT) of the head performed because of alterations in mental status may be normal or may reveal diffuse white-matter petechial hemorrhages consistent with microvascular injury.* GURD criteria are used for diagnosis of fat embolism and one major criterion, four minor criteria, and the presence of macroglobulinemia are required for the diagnosis.
Oil Red O stain for fat
Noncardiogenic pulmonary edema
Gurd criteria
Diffuse white matter petechial hemorrhage
C.V.S