Lady 45-years of age with decreased oestrogen level increased testosterone and temporal hair recession. Diagnosis is?
Testosterone is the most important androgen in both men and women.
In women, testosterone is produced primarily through peripheral conversion of androstenedione (50 percent) with the remainder of production concentrated in the ovary (25 percent) and adrenal cortex (25 percent).
In women, abnormally high levels of testosterone have been associated with hirsutism and polycystic ovary syndrome.
Granulosa-theca cell tumors, more commonly known as granulosa cell tumors, belong to the sex cord-stromal category and include tumors composed of granulosa cells, theca cells, and fibroblasts in varying degrees and combinations.
Both subtypes commonly produce estrogen, and estrogen production often is the reason for early diagnosis.
Osteoporosis
Rheumatoid arthritis
P.C.O.D
Granulosa theca cell tumour