Which of the following is most reliable feature of malignat transformation of pheochromocytoma?
Determination of malignancy in pheochromocytoma is difficult. Benign pheochromocytomas show mitotic figures and vascular and capsular invasion. So none of the above said features will help to determine malignancy. Therefore,the definitive diagnosis of malignancy in pheochromocytoma is based exclusively on the presence of metastases. Ref: Robbins and cotrans 9e
Presence of mitotic figures
Capsular invasion
Vascular invasion
None
Endocrinology