Which of the following Is responsible for pubeal growth in females :
The onset of pubey is associated with high GnRH pulsing, which precedes the rise in sex hormones, LH and FSH. Exogenous GnRH pulses cause the onset of pubey. Brain tumors which increase GnRH output may also lead to premature pubey.The cause of the GnRH rise is unknown. Leptin might be the cause of the GnRH rise. Leptin has receptors in the hypothalamus which synthesizes GnRH. Individuals who are deficient in leptin fail to initiate pubey. The levels of leptin increase with the onset of pubey, and then decline to adult levels when pubey is completed. The rise in GnRH might also be caused by genetics. A study discovered that a mutation in genes encoding both Neurokinin B as well as the Neurokinin B receptor can alter the timing of pubey. The researchers hypothesized that Neurokinin B might play a role in regulating the secretion of Kisspeptin, a compound responsible for triggering direct release of GnRH as well as indirect release of LH and FSH.
Decreased level of adrenal androgens at pubey
High level of estrogen at pubey
Pulsatile release of GnRH during sleep
Increased sensitivity of HPO axis to estrogen
Sexuality and intersexuality