Good prognosis factors of ALL are all EXCEPT:
Pre B cell ALL REF: Devita's ed p. 2240, Nelson 17" ed p. 1695 Prognostic factors for ALL Determinants Favourable Unourable WBC count Low High Age 3-7 yrs <1, > 10 yrs Sex Female Male Race White Black Hepatosplenomegaly and lymphadenopathy Absent present Testicular involvement Absent Present CNS Absent Ove FAB classification L1 L2 PLOIDY Hyperdiploidy hypoploidy Cytogenetic markers Trisomy 4,10, 7 7 t(12:21) tel:aml t(9:22) (bcr:abl) t(4:11) (mil af4) t(1:19) Time of remission <14 d >28 d Minimal residual disease <10-4 >10-3 Immunophenotype Early pre B cell T cell
Hyperdipoidy
Female sex
Pre B cell ALL
T (12:2) translocation