Which of the propeies accounts for ethanol's use in ethylene glycol poisoning?
Ethanol acts by competing with ethylene glycol for alcohol dehydrogenase, the first enzyme in the degradation pathway. Because ethanol has a much higher affinity for alcohol dehydrogenase, about a 100-times greater affinity, it successfully blocks the breakdown of ethylene glycol into glycoaldehyde, which prevents the fuher degradation. Ref: Lehninger Principles of Biochemistry, 4th Edition, Page 336; Updates in Emergency Medicine By John Cahill, 2002, Page 115
Competitive inhibitor of NADPH oxidase
Competitive inhibitor of alcohol dehydrogenase
Competitive inhibitor of aldehyde dehydrogenase
Non-competitive inhibitor of aldehyde dehydrogenase