TRUE statement about achalasia cardia is:
Achalasia is a rare disease It is caused by loss of the ganglion cells within the esophageal myenteric plexus With long-standing disease, viual aganglionosis is noted. Pathology: Impaired deglutitive LES relaxation and absent peristalsis. It is believed that cause of ganglion cell degeneration in achalasia is an autoimmune process attributable to a latent infection with human herpes simplex virus 1 combined with genetic susceptibility. Ref: Harrison, Edition-18, Page-2431.
Achalasia is a common disorder
Loss of ganglion cells within the esophageal myenteric plexus
Excess LES relaxation is the major pathology
Latent infection with rubella virus is responsible for it