The combination of alcohol and disulfiram results in nausea and hypotension as a result of accumulation of:
Disulfiram is an aldehyde dehydrogenase inhibitor that can be used for de-addiction of chronic alcoholics. Due to inhibition of aldehyde dehydrogenase, there is accumulation of acetaldehyde that leads to several distressing symptoms (which strengthens the resolution of a person to quit alcohol).
Acetaldehyde
Acetate
Methanol
NADH
Opioids and Alcohols