Regarding liver enzymes true is?
Glutathione-s-transferase used as hepatic prognostic marker following surgery REF: Harrison's Internal Medicine 17th edition chapter 298 The aminotransferases (transaminases) are sensitive indicators of liver cell injury and are most helpful in recognizing acute hepatocellular diseases such as hepatitis. They include the aspaate aminotransferase (AST) and the alanine aminotransferase (ALT) There is a poor correlation between the degree of liver cell damage and the level of the aminotransferases. Thus, the absolute elevation of the aminotransferases is of no prognostic significance in acute hepatocellular disorders. Alanine aminotransferase: Alanine aminotransferase (ALT) was formerly known as SGPT. This enzyme enters the blood when liver cells are damaged or destroyed and circulates for a few days. ALT is found primarily in the liver. (More specific for liver pathology) This enzyme is a sensitive indicator of active liver damage but does not indicate the cause or reversibility of the damage. An increase of at least three times normal indicates significant liver damage within the previous 2 to 5 days. Aspaate aminotransferase: Aspaate transaminase (AST), also called as serum glutamic oxaloacetic transaminase (SGOT). AST is found in the liver, cardiac muscle, skeletal muscle, kidneys, brain, pancreas, lungs, leukocytes, and erythrocytes in decreasing order of concentration. Alpha Glutathione S-Transferase (GST) Increased GST indicates early hepatocyte injury. Alpha glutathione S-transferase (GST) is a superior marker of hepatocyte injury from toxicity; ischemia, and other liver injury. It is unique to hepatocytes, found in high concentrations, and is readily released in response to injury. Its rapid release into and removal from the circulation provides immediate information regarding liver status.
ALT is less specific than AST
Absolute levels of enzyme markers correlate with outcome
Glutathione-s-transferase used as hepatic prognostic marker following surgery
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