In which variety of lung cancer cranial irradiation is also given in treatment?
ANSWER: (B) Small cell cancerREF: Harrison's 18th ed chapter 89Prophylactic Cranial Irradiation:Prophylactic cranial irradiation (PCI) should be considered in all patients with LD (local disease) - and ED (extended disease)-Small cell lung cancer (SCLC) who has responded to initial therapy. A meta-analysis including 7 trials and 987 patients with LD-SCLC who had achieved a complete remission following primary chemotherapy reported a 5.4% improvement in overall survival for patients treated with PCI. In patients with ED-SCLC who had responded to first- line chemotherapy, PCI reduced the occurrence of symptomatic brain metastases and prolonged disease-free and overall survival compared to no radiation therapy. Long-term toxicides includingdeficits in cognition have been reported following PCI and are difficult to sort out from the effects of chemotherapy or normal aging.
Squamous cell carcinoma
Small cell cancer
Non small cell cancer
Ademocarcinoma
Radiation treatment planning