Macrophages containing large quantities of undigested and partial digested bacteria in the intestine are seen in -
The hallmark of Whipple’s disease is a small intestinal mucosa laden with distended macrophages in the lamia propria.
The macrophages contain periodic acid– Schiff (PAS) positive granules and small rod shaped bacilli)
Whipple's disease
Amyloidosis
Immunoproliferative small intestinal disease
Vibrio cholerae infection