Hera lal a 35 year old man was found to be positive for HBsAg and HBeAg , accidentally during a screening for blood donation. On Lab examination SGOT and SGPT are normal. What should be the most appropriate next step?
Patient in the question is positive for HBsAg and HBeAg, so he is more likely to be highly infectious and must be associated with the presence of Hepatitis B virions and a detectable HBV DNA. Ref: Harrisons Internal Medicine, 18th Edition, Chapter 304, Page 2540 ; Review of Medical Microbiology and Immunology By Warren Levinson, 11th Edition, Chapter 41
Observation
Liver biopsy
Interferon therapy
HBV-DNA estimation