A patient requires mild cholinomimetic stimulation following surgery. Physostigmine and bethanechol in small doses have significantly different effects on which of the following?
Ans. (B) Neuromuscular junction(Ref: Katzung 11/e p98)Bethanechol acts on muscarinic receptors only whereas physostigmine increases ACh, thus can stimulate both muscarinic and nicotinic receptors. Neuromuscular junction contains NM receptors, thus will be affected by physostigmine but not by bethanechol.
Gastric secretion
Neuromuscular junction
Sweat glands
Ureteral tone
A.N.S.