True statement about neostigmine aa
Refer kDT 6/e p 101,102 neostigmine is a reversible cholinesterase inhibitor. It is a quaernary ammonium compound(lipid insoluble agent) So it doesn't cross blood brain barrier It is paly hydrolysed by serum cholinesterase and paly excreted unchanged by the Kidneys It possesses some agonistic action on Nm receptors
It is quaternary Ammonium compounds
It is metabolized by liver
It can cross blood brain barrier
Prominent effect on cardiac muscle
Autonomic nervous system