A female has hypopigmented lesion of centre of forehead. Drug responsible is ?
Parateiary butyl phenol Hypopigmented lesions on the centre of the forehead suggests chemical leucoderma with parateiary butyl phenol. Chemical leucoderma means an acquired vitiligo like hypomelanosis induced by repeated exposure to specific chemical compounds. Parateiary butyl phenol is used in concentration of 80% in the adhesives of sticker bindi & is known to cause contact depigmentation. Other uses of parateiary butyl phenol Rubber (cause contact dermatitis in shoe wearers) Phenolic germicides Lipsticks Also know Other compounds associated with chemical leucoderma Parateiary butyl catechol Present in ceain hair colours Hydroquinone It is a component of bleaching creams used for lightening the skin in states of hyperpigmentation like melasma. Its prolonged use causes exogenous ochronosis. Monobenzyl ether of hydroquinone Used in rubber. It is also called agerite alba. Causes contact dermatitis in those who wear rubber gloves. Occupational causes of leucoderma Bindi and footwear Parateiary butyl phenol Acid cured gloves - Monobenzyl ether of hydroquinone Rubber Parateiary butyl phenol Parateiary octyl phenol Parateiary butyl phenol formaldehyde Hair colors rinse Para-phenylenediamine Phenolic detergent Parateiary butyl phenol Parateiary amyl phenol Most potent agent causing chemical leucoderma is monobenzyl ether of hydroquinone.
Hydroquinone
Ether metabolite of hydroquinone
Para teiary butyl catechol
Para teiary butylphenol