A neurosurgeon saw a child with precocious pubey and uncontrollable laughing. He suggested the parent of child to get a MRI done to evaluate for the possibility of?
Hypothalamic hamaomas and gangliocytoma may arise from astrocytes, oligodendrocytes, and neurons with varying degrees of differentiation. These tumors may overexpress hypothalamic neuropeptides, including GnRH, GHRH, and CRH. With GnRH-producing tumors, children present with precocious pubey, psychomotor delay, and laughing-associated seizures. Medical treatment of GnRH-producing hamaomas with long-acting GnRH analogues effectively suppresses gonadotropin secretion and controls premature pubeal development. Ref:Melmed S., Jameson J.L. (2012). Chapter 339. Disorders of the Anterior Pituitary and Hypothalamus. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.
Craniopharyngioma
Hypothalamic Hamaoma
Pheochromocytoma
Pituitary adenoma