In a case of ectopic pregnancy, medical treatment is contraindicated if:
Criteria for medical treatment 
1) Ectopic mass <3.5cm – the presence of fetal cardiac activity is a contra-indication to medical treatment
2) No fetal cardiac activity
3) Initial hCG <3000iu/l
4) The patient must be hemodynamically stable, with no signs or symptoms of active bleeding or hemoperitoneum.
5) She should not have any contraindications to the use of methotrexate.
Sac size is 3.0 cm
Serum HCG levels > 1500 miu / ml
Significant hemoperitoneum is present
Absent fetal activity