True statement regarding use of antiepileptic drugs in pregnancy
Neural tube defects are associated with valproate. fetal anticonvulsant syndrome or fetal hydantoin syndrome :risk is increased with the number of drugs.the cause is thought to be folate defeciency as these drugs interfere with folate metabolism monotherapy is associated with lower risk TEXTBOOK OF GYNECOLOGY,SHEILA BALAKRISHNAN,Pg no:330,2nd edition
valproate is associated with NTD
Multiple drug should be given
carbamazepine is used as monotherapy
phenytoin can produce foetal hydantoin syndrome
Medical, surgical and gynaecological illness complicating pregnancy