Hirschsprung&;s disease is due to
.* It is a congenital, familial condition, occurring in newborn due to the absence of ganglion cells-- Auerbach's and Meissner's plexus in anorectum, which may extend proximally either a pa or full length of the colon. ref:SRB&;s manual of surgery,ed 3,pg no 818
Loss of ganglion cells in the sympathetic chain
Atrophy of longitudinal muscles
Failure of migration of neural crest cells from cranial to caudal direction
Malformed teania coli
G.I.T