Ketone bodies are used by all except ?
Ans. is 'd' i.e., Hepatocytes Ketone bodies are synthesized by liver and are utilized by extrahepatic tissues like hea, muscles, renal coex and brain (in starvation). Liver cannot utilize ketone bodies because it lacks enzyme succinyl-CoA-acetoacetate CoA transferase, which is required for the activation of ketone bodies. The first reaction in use of ketone bodies is activation of acetoacetate. CoA-transferase Succinyl CoA + acetoacetate ___________________ Acetoacetyl CoA + succinate
Brain
RBCs
Skeletal muscles
Hepatocytes