Lupus anticoagulants may cause all of the following except:
Answer is C or None (Increased PT or None) Prothrombin time Ic usually not affected by Lupus Anticoagulant. The Lupus Anticoagulant typically causes an isolated prolongation of APTT. Prothrombin time is usually normal although slight prolongation in PT may also be observed `Lupus anticoagulant should be suspected in cases of markedly prolonged PTT without clinical bleeding and normal or slightly elevated PT'- CMDT The presence of LA activity may predispose patients to venous and aerial thromboembolism and may cause mid trimester aboions - Harrisons 16`11/685 VDRL tests for syphillis are non specific tests, detecting anticardiolipin antibodies. Lupus anticoagulants are family of antiphospholipid antibodies of the same class and may give a false positive VDRL. Causes of false positive VDRL reactions: Acute false positive (< 6 months) Chronic false positive ( 6 months) Recent viral infection / immunization * Aging Genital herpes * Autoimmune disorders Human immunodeficiency virus * SLE Malaria * RA Parentral drug use * Parentral drug use.
Recurrent aboion
False+ve VDRL results
Increase prothrombin time
Aerial thrombosis