Mechanism of action of quinolones is?
ANSWER: (A) DNA gyrase inhibitorsREF: Goodman G ill man s 11th ed p. 722The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram positive bacteria, topoisomerase IV is the primary target. For many gram-negative bacteria, DNA gyrase is the primary quinolone target.
DNA gyrase inhibitors
Bind to 30 s unit
Bind to bacterial cell membrane
Bind to tetrahydofolate reductase
Anti Microbial