A person working in rose garden presented with the following lesion. Wof is the Causative agent
Sporotrichosis * Caused by Sporothrix schenckii, a dimorphic fungus present worldwide upon decaying vegetation (e.g., wood splinters, plant thorns, sphagnum moss) * Acquired by traumatic implantation (classic presentation was as "rose gardener disease") * Infection spreads centripetally by lymphatic vessels (origin of the term "sporotrichoid spread") Clinical:- (cutaneous forms) * Fixed cutaneous form - Single inoculation site with scaly, acneiform, verrucous, or ulcerative nodule; possibly with local lymphadenopathy * Lymphocutaneous form - Ulcerative nodules on extremities, sporotrichoid spread along lymphatics * Disseminated disease - Occurs in immunocompromised patients; may cause pulmonary lesions, septic ahritis/synovitis, mucosal lesions, pyelonephritis, orchitis, mastitis, meningitis, osseous infection, etc Diagnosis Histology:- Inflammation and pseudoepitheliomatous hyperplasia; sparse and rare cigar-shaped yeast; extracellular asteroid bodies may be present (yeast surrounded by refractile eosinophilic halo) Culture:- Gold standard; growth inhibited by cycloheximide; at 37degC culture yields creamy, white-tan colonies in 7 days, colonies turn brown-black in center with age - Yeast phase at 37degC : elongated, cigarshaped yeasts; rarely seen in histologic sections of tissue - Mold/mycelial phase at 25degC septate hyphae, delicate conidiophores bearing pyriform (pear-shaped) conidia in rosette clusters Ref:- Dermatology review by Asra Ali; pg num:-364,365
Sporothrix schenckii
Histoplasma capsulatum
Coccidioides immitis
None of the above
Fungal infections, Scabies, Pediculosis