Which of the following phospholipid is predominantly found in the inner mitochondrial membrane?
Cardiolipin: Diphosphatidyl glycerol i.e. 2 phosphatidic acid moieties attached to glycerol. Found in inner mitochondrial membrane. Physiological role: Increases the efficiency of the oxidative phosphorylation by acting as proton trap. Involved in signalling of apoptosis (programmed cell death). Anticoagulant Pathological role: Bah syndrome - defective biosynthesis of Cardiolipin. Antiphospholipid syndrome thrombotic condition leading to aboion. Anti-cardiolipin antibodies are found.
Cardiolipin
Cephalin
Lecithin
Sphingomyelin
Chemistry of Lipids