Muscles cannot make use of glycogen because of deficiency of :
It is because of the deficiency of Glycogen Phosphorylase. It is the first and rate-limiting enzyme of glycogenolysis. Deficiency of Glycogen phosphorylase in muscles is known as Mc Ardle's disease The other question usually asked is why muscle cannot maintain blood glucose then the answer is due to lack of enzyme glucose- 6-phosphatase. Glucose-6-phosphatase is required for maintainence of blood glucose and not utilization of glycogen. This enzyme is present in Liver. Option 3 Hexokinase is enzyme of glycolysis and not glycogen breakdown. Option 4- phosphoglucomutase though an enzyme involved in glycogen breakdown its deficiency is extremely rare with no clearly defined physiological symptoms.
Glucose-6-phosphatase
Glycogen phosphorylase
Hexokinase
Phospho-gluco-mutase
Glycogen