Adverse Adverse effects of phenytoin include all of the following except?
Phenytoin interferes with calcium metabolism by desensitizing target tissue to vit. D, this causes hypocalcemia (not hypercalcemia). At therapeutic level (10-20microg/ml) - Gum hyperophy, hirsutism, hypersensitivity (rashes, lymphadenopathy, DLE, neutropenia), hyperglycemia due to inhibition of insulin release, megaloblastic anemia, pseudolymphoma, hypocalcemia, Vitamin D deficiency and osteomalacia, and teratogenicity (fetal hydantoin syndrome). At toxic level (dose-related) cerebellar syndrome (ataxia, veigo), falling BP, arrhythmias, drowsiness, mental confusion, Gl symptoms (epigastric pain, nausea, vomiting) and local vascular injury by iv injection. REF : katzung pharmacology : 14th ed
Lymphadenopathy
Ataxia
Hypercalcemia
Hirsutism
All India exam