Regarding dihydroaemisinin pharmacokinetics, all are true except:-
Dihydroaemisinin * It has potent schizontocidal action.* These drugs are lethal to early malarial gametes but not mature ones.* They do not kill vivax hypnozoites* The duration of action is sho and recrudescence rate is high.* Dose adjustment is not required in hepatic or renal failure.* Oral bioavailability is around 30%* Auto induction of metabolism.
Dose adjustment is not required in hepatic or renal failure
Has a long half life
Oral bioavailability is around 30%
Autoinduction of metabolism
Anti-Malaria Drugs