Which of the following can be given with dose adjustment?
The most impoant interaction involving tetracyclines is reduced absorption when these drugs are coadministered with divalent and trivalent cations, such as antacids, iron compounds, or dairy products. Administrations of these substances and tetracyclines should be staggered, if they cannot be avoided altogether. All other combinations are contraindicated. By blocking DA receptors in basal ganglia, metoclopramide abolishes the therapeutic effect of levodopa. Chlorpromazine and tricyclic antidepressants abolish the antihypeensive action of clonidine, probably by blocking the alpha receptors on which clonidine acts. High ceiling diuretics and aminoglycoside antibiotics are both ototoxic; produce additive toxicity; should not be used together. Ref: Archer G.L., Polk R.E. (2012). Chapter 133. Treatment and Prophylaxis of Bacterial Infections. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.
Levodopa + metoclopramide
Gentamicin + Frusemide
Ferrous sulphate + Tetracycline
Clonidine + Chlorpromazine