Lamivudine is recommended for treatment of chronic hepatitis B when:
Answer is C (ALT > 2x ULN) The primary indication of antiviral treatment in chronic hepatitis B is elevation of ALT levels to more than 2 times the upper limit of normal. Antiviral treatment is recommended for treatment of chronic hepatic B in both HBe Ag positive and HBe Ag negative individuals when HBV DNA > 2 x 104 U/m1 and ALT > 2 times ULN. Lamivudine is the first of the nucleoside analogues to be approved and may be used for Antiviral treatment in such cases although newer, more potent agents are now generally preferred.
HBe Ag positive
HBe Ag Negative
ALT > 2 xULN
Viral DNA > 102 copies