Which of the following immunoglobulins can cross placenta ?
Ans is 'c' i.e., IgG IgG It is the major serum immunoglobulin (80%). It is distributed equally between the intravascular and extravascular compaments. It contains less carbohydrate than other immunoglobulins. It has maximum half life. It binds to micro-organisms and enhances their phagocytosis. Considered as general purpose antibody, protective against those infectious agents which are active in the blood and tissues. It is the predominant antibody in secondary antibody response. Four subclasses of IgG are there with IgG, is found in greatest amount and IgG4 in least amount. IgG, is directed against polysaccharide antigen so it is impoant in defence against encapsulated bacteria. IgG is the only maternal immunoglobulin, that is normally transpoed across the placenta and provides natural passive immunity in the newborn.
IgA
IgM
IgG
IgD