Regarding aprepitant all are true except:
it is a recently introduced selective high affinity NK1 receptor antagonst that blocks the emetic action of substance P,with little effect on 5HT3and D2 or other receptor ESSENTIALS OF MEDICAL PHARMACOLOGY SEVENTH EDITION KD TRIPATHI PG NO.669
Agonist at NK1 receptors
Crosses Blood Brain Barrier
Ameliorate nausea and vomiting induced by chemotherapy
Metabolized by CYP450 enzymes
Gastrointestinal tract