Tensile strength of wound after laparoscopic cholecystectomy in a 30 years old woman depends upon:
The recovery of tensile strength results from the excess of collagen synthesis over collagen degradation during the first 2 months of healing, and, at later times, from structural modifications of collagen fibers (cross-linking, increased fiber size) after collagen synthesis ceases.
Replacement of type 3 collagen
Extensive crosslinking of tropocollagen
Macrophage activity/invasion
Granulation tissue