True for lithium:-
LITIHIUM* Well absorbed orally(peal level in 2- 3 hours)* Not protein bounded * Handled by kidney * Very narrow therapeutic index * Lithium concentration for optimizing therapy - 0.5 -0.8meq/l - bipolar disorder - 0.8 -1.2meq/l - acute mania - >1.5meq/dl -toxicity * S/E - fine tremors - CNS toxicity - coarse tremors ,ataxia , hyperflexion, mental confusion - >2meq/l -muscle twitching , drowsiness ,convulsions ,coma* Diabetes insipidus * Weight gain * C/I - pregnancy - congenital defect (Ebstein anomaly is associated with lithium exposure)* USE - bipolar disorders - Acute mania
Delayed absorption
Narrow therapeutic index
Protein bound
Can be given safely in renal dysfunction
FMGE 2018