All statement about Plummer–Vinson syndrome are true except -
Plummer-Vinson syndrome

Plummer-Vinson syndrome, also known as Brown-Kelly-Paterson syndrome or sideropenic dysphagia, seen in middle-aged edentulous women.
The plummer Vision Paterson Brown-Kelly Syndrome is characterized by : -


Dysphagia
Chronic iron deficiency anaemia
Atrophic oral mucosa and glossitis
Brittle, spoon-shaped fingernails (Koilonychia)


The cause of dysphagia is usually a cervical esophageal web, but abnormal pharyngeal and esophageal motility may play a role.
The syndrome characteristically occurs in middle-aged edentulous (without teeth) women.
It is a premalignant lesion. Approximately 10% of patient develop squamous cell Ca of esophagus, oral cavity or the hypopharynx.
As iron-deficiency anemia is a common finding, it is also known as sideropenic dysphagia.
Carcinoma develops in the postcricoid region (not in the lower third oesophagus).
Commonly leads to carcinoma in lower third of esophagus
Common with iron deficiency
Common in females
Premalignant