Primary abnormality in sequence of events leading to DIC is-
The sequence of events in DIC are: activation of coagulation, thrombotic phase,consumption phase,secondary fibrinolysis. Massive tissue injury ,infections ,widespread endothelial damage stimulates widespread activation of coagulation pathway bye release of tissue factor & uncontrolled thrombin generation is the primary pathway.Reference:Harsh mohan textbook of pathology sixth edition pg no 337
Fibrin deposits in multiple sites
Uncontrolled thrombin generation
Abnormal adhesion and consumption ofplatelets
Destruction of red cells
Haematology