Which toll like receptors are involved in action of bacterial endotoxins -
Ans. is 'b' i.e., II o Ten different mammalian Toll like receptors (TRRs) have been identified --> TLR 1 to 10. o TLRs are involved in responses to widely divergent types of molecules that are commonly expressed by microbial but not mammalian cells. TLR Microbial ligand molecules Peptidoglycan of Gram (+)ve bacteria zymosan of fungi GPI anchor of Trypanosomes Lipoarabinomannan of mycobacteria LPS (endotoxin) of Leptospira Lipoproteins of bacteria Double - stranded DNA of viruses LPS (endotoxin) of all other gram (-)ve bacteria HSF 00 of chlamydia Flagellin of bacteria CpG DNA of bacteria and protozoa Note ? o Bacterial endotoxin of all gram (-)ve organisms, bind to TLR-4, except Leptospira. o Endotoxin of leptospira binds to TLR-2.
I
II
III
V