Pain in endometrium is closely associated with
Ans B Ref: Williams gynaec page 230Underlying cause of pain is unclear: proinflammatory cytokines (PGF2alpha) released by the endometriotic implants into peritoneal fluidEvidence to suggest that pain from endometrium correlate to depth of invasion and site of pain- many indicate lesion location.Recent data suggest pain result from neuronal invasionRef: Sheila Balakrishnan, gynaec page 143Severe endometriosis can produce pain by peritoneal inflammation, deep infiltration and scarring, invasion of nerve endings, adhesions, collection of menstrual blood.
site of endometrium
depth of invasion
stage of disease
size of lesion
Miscellaneous