Which is true regarding IL-1?
Produced by tissue macrophages, monocytes, fibroblasts and dendritic cells and also expressed by B cells, lymphocytes, NK cells and epithelial cells Increases the expression of adhesion factors on endothelial cells to enable transmigration Causes fever, hyperalgesia, vasodilation and hypotension
Mainly derived from neutrophils
Produces necrosis of tumor cells
Increases expression of MHC coded proteins
Upregulates adhesion molecules
General pathology