Which of the following anti tubercular drug requires dose adjustment in renal failure:
Ref: Katzung's Pharmacology, 14th ed. pg. 846* Dose of Ethambutol: 15-25mg/kg OD dose.* About 20% drug is excreted in feces and 50% in urine in unchanged form.* Ethambutol accumulates in renal failure, and the dose should be reduced by half if creatinine clearance is less than 10mL/min.* Side effect: Most common serious adverse event is retrobulbar neuritis, resulting in loss of visual acuity and red green color blindness (Patient develop BLUE VISION).# It can also cause hyperuricemia and peripheral neuritis.* It is also Contraindicated in children as they are unable to report loss of visual acuity and red-green color discrimination.
Isoniazid
Rifampicin
Pyrazinamide
Ethambutol
Anti Microbial