A 40 year old lady with breast cancer has undergone MRM and is on Tamoxifen for 1 year. She now has presents with bleeding per vaginum 4-5 times. What is the probable cause:
Ans. (b) Endometrial cancerRef: KDT 6th ed. / 304-5* Tamoxifen is selective estrogen receptor modulator (SERM).* It is having agonistic activity at uterine endometrium.Action of TamoxifenAgonistic activityAntagonistic activityUterus: causes proliferation of endometrium - can cause vaginal bleeding as seen in the caseBreast CABone: decrease resorptionBlood vesselsLipid profile: decrease LDL without affecting HDL ->> decrease risk of CAD
Bleeding disorder
Endometrial cancer
Ovarian cancer
Cervical cancer
Anti-Neoplastic Agents