The enzyme deficient in Lysch Nyhan syndrome is:-
HGPase (Hypoxanthine guanine phosphoribosyl transferase) deficiency: Causes Lesch-Nyhan syndrome. | synthesis of purine nucleotides |utilization of purines (hypoxanthine and guanine) by salvage pathway-accumulation of PRPP (Neurotoxic component)- Self mutilation Defect in salvage pathway- | IMP and CMP - impairment feedback regulation of their production
Adenosine Deaminase
PRPP synthetase
HGPase
Xanthine oxidase
NEET 2018