Which of the following cell type(s) secretes prostate specific antigen (PSA)?
Prostate-specific antigen (PSA), a glycoprotein with a MW of 34,000, is a biological marker used in the detection of prostate cancer. It is secreted from prostatic epithelial cells and is responsible for aiding liquefaction of semen. This marker, which is evaluated with a blood test, can be produced by both benign and malignant epithelial cells. The prostate stromal cells do not produce PSA. Ref:Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 23. Function of the Male Reproductive System. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.
Benign prostate epithelial cells only
Malignant prostate epithelial cells only
Benign and malignant prostate epithelial cells
Prostate stromal cells