Ulcerative colitis what is seen
Histologically, ulcerative colitis because of remission and exacerbations, is characterized by alternating 'active disease process' and 'resolving colitis.' The changes in the 'active disease process' are as under (Fig. 20.28): 1. Crypt distoion, cryptitis and focal accumulations of neutrophils forming crypt abscesses. 2.Marked congestion, dilatation, and hemorrhages from mucosal capillaries. 3. Superficial mucosal ulcerations, usually not penetrating into the muscle coat, except in severe cases, and is accompanied by nonspecific inflammatory cell infiltrate of lymphocytes, plasma cells, neutrophils, some eosinophils and mast cells in the lamina propria. 4. Goblet cells are markedly diminished in cases of active disease. 5.Areas of mucosal regeneration and immunodepletion of lining cells. 6.In long-standing cases, epithelial cytologic atypia ranging from mild to marked dysplasia and sometimes developing into carcinoma in situ and frank adenocarcinoma. REF: TEXTBOOK OF PATHOLOGY HARSH MOHAN 6TH EDITION, PAGE NO:568,569 IMAGE REF: TEXTBOOK OF PATHOLOGY HARSHMOHAN 6TH EDITION, FIG. 20.28, PAGE:569
Cryptitis
Crypt loss
Crypt branching
Proliferating mucosa
G.I.T