Analgesic effect of paracetamol is mediated by action on which of the following receptor?
PCM uses - Fever Pain Not for inflammation Peroxide:- Presence of peroxide at inflammation site inactivate PCM. COX3 inhibitor :- Presence of COX3 in brain, therefore fever and pain can be treated with PCM. Vanilloid receptor:-Metabolites of PCM binds with vanilloid receptor to produce analgesia. Transient Receptor Potential vanilloid 1:TRPV 1
NK 1
BK 1
Px23
TRPV 1
DNB 2018