All are liver function test alterations in bacterial sepsis, EXCEPT:
JAUNDICE IN BACTERIAL SEPSIS (1) Dispropoionate increase in serum bilirubin compared to aminotransferase and ALP (2) It can appear even without fever / hypotension, Leukocytosis (3) Mechanisms : Endotoxin mediated cytokine activation (4) It impairs transpo of anions in both sinusoidal and canalicular membranes resulting in impaired bile flow Ref: schiff's diseases of liver : E - 11, P - 232.
Elevation of bilirubin with normal liver enzymes
LFT alteration is due to the endotoxemia
Endotoxemia impairs transpo of anions, resulting in impaired bile flow
Jaundice is always associated with leukocytes