Select the regime of coicosteroids which has the maximum adverse effect potential?
* If used for more than two weeks, coicosteroids can lead to HPA axis suppession. If discontinued abruptly, precipitation of acute adrenal insufficiency can result. This is the most serious adverse effect seen with the use of coicosteroids that can cause death of the patient.
Prednisolone 20 mg/day oral for one year
Prednisolone 60 mg/day oral for 7 days
Dexamethasone 4 mg intravenous daily for 3 days
Methyl-prednisolone 1000 mg intravenous twice single dose
Adrenal