Adequacy of D-penicillamine treatment in wilson is monitored by measuring the:
D-Penicillamine treatment in wilson disease: Adequacy of treatment is monitored by measuring 24-hour urinary copper excretion while on treatment. The most impoant sign of efficacy is a maintained clinical and lab improvement. Serum ceruloplasmin decrease after initiation of treatment. Ref: Journal of Hepatology 2012 vol. 56 / 671-685.
24 hour urinary copper
Serum ceruloplasmin
Disappearance of KF ring
Serum copper level in the fasting state