Sensitivity of central chemorecepter in COPD -
Ans. is 'a' i.e., Decreased to H+ o Primary stimulus for central chemoreceptors is an increase in hydrogen ion concentration (H) in CSF. o But, central chemoreceptors are depressed in hypoxia (COPD causes hypoxic hypoxia). "Central chemoreceptors are not stimulated by hypoxia; rather like any other cells, they are depressed by- hypoxia " ___ Priciples of medical physiology o Thus, COPD will cause depression of central chemoreceptors to other stimuli as it causes hypoxic hypoxia.
Decreased to H+
Increased to H+
Increased to PCO2
Increased to PO2
Regulation of Respiration