A patient presents with fever, cough with sputum and weight loss. He has a history of not completing treatment for tuberculosis thrice in the past. XDR-TB is suspected. How is XDR-Tb defined?
XDR-TB (Extensively drug-resistant TB) is defined as MDR TB (Resistant to rifampicin and isoniazid) + Resistant to one fluoroquinolone (eg. ofloxacin) + resistance to one injectable second line drug (Amikacin or kanamycin or capreomycin). Reference: Ananthanarayan and Paniker&;s Textbook of Microbiology Tenth edition
Resistant to INH + Rifampicin + Amikacin
Resistant to INH + Amikacin + Ofloxacin + Ethambutol
Resistant to INH + Rifampicin + Amikacin + Ofloxacin
Resistant to Rifampicin + Amikacin+ Ofloxacin
Bacteriology