Cardiotoxicity of bupivacaine -
Ans. is 'a' i.e., Depressed pacemaker activity o Local anaesthetics block cardiac sodium channels and thus depress abnormal cardiac pacemaker activity, excitability, and conduction. At extremely high concentrations, local anaesthetics can also block calcium channels.
Depressed pacemaker activity
Toxic compound damaging myocardial cells
Depressed neural control on hea
Vascular thrombosis and Myocardial ischemia