Acute alcohol consumption causes:
Raf: Harrison's Principles of Internal Medicine, 18thedition, pg 3546Explanation:Alcohol inhibits gluconeogenesis, and hence hypoglycemia occurs acutely.Ethanol is oxidized to acetaldehyde, which causes NAD reduced to NADHHigh NADH - increase lactate levels, impair gluconeogenesis. increase in beta -OH butyrate levels which is the predominant ketone in alcoholic keto acidosis (AKa).In AKA, mild hyperglycemia with ketonemia occurs.Alocohol increases GABAReleases cortisol. ACTH. dopamine & glutamateHypoglycemia Alcoholic ketoacidosisGABA enhancer, diminishes NMDA, anti-convulsant. sleep-inducing, antianxiety, muscle relaxationEnhances dopamine, craving, increases cortisol. ACTHBeta endorphin & glutamate releaseEffects of Blood Alcohol Levels in the Absence of ToleranceBlood Level, g/dLUsual Effect0.02Decreased inhibitions, a slight feeling of intoxication0.08Decrease in complex cognitive functions and motor performance0.20Obvious slurred speech, motor incoordination, irritability, and poor judgment0.30Light coma and depressed vital signs0.40Death
Inhibits ketogenesis
Lactic acidosis
Increased gluconeogenesis
Decreases brain GABA
Toxicology