All of the following are histological features of Hashimoto thyroiditis, except:
All of the above histological features are of Hashimoto thyroiditis except Orphan Annie eye nuclei - It is seen in papillary carcinoma of thyroid. Hashimoto thyroiditis: Autoimmune disease that is caused by immune response to thyroid autoantigens. Painless enlargement of the thyroid often in middle age women M/C cause of hypothyroidism in iodine sufficient areas Increased risk for the development of B-cell malignancy - marginal zone lymphomas. Infiltrates of lymphocytes with germinal center formation, follicular damage present. Thyroid follicles are atrophic and are lined in many areas by Huhle cells (pink granular eosinophilic cytoplasm, oncocytic metaplasia).
Lymphocytic infiltrate with germinal center formation
Follicular destruction and atrophy
Huhle cell metaplasia
Orphan Annie eye nuclei
Thyroiditis