All of the following are true about HMG CoA reductase inhibitor except
Refer Goodman and Gilman 11e p950 Prevastatin has least chances of drug interactions because it is metabolized by non microsomal enzyme. It also have minimum chances of myopathy among stations. Bioavailability of prevastatin is leastly affected with food intake. It has little CNs penetration
CNs accumulation of simvastatin and livastatin is high & less for prevastatin and fluvastatin
Simvastatin is rapidly and prevastatin is leastly metabolized
Bioavailability is minimally modified when prevastatin is taken with food
Fibrinogen levels are increased by prevastatin
Cardiovascular system