Agent causing malignant hypehermia is?
Succinylcholine REF: Goodman and Gillman p. 152 11th edition "Succinylcholine is the most common drug used in anesthesia to cause Malignant Hypehermia" MALIGNANT HYPEHERMIA Malignant hypehermia is a potentially life-threatening event triggered by ceain anesthetics and neuromuscular blocking agents. Clinical features: contracture, rigidity, and heat production from skeletal muscle resulting in severe hypehermia, accelerated muscle metabolism, metabolic acidosis, and tachycardia. Mechanism: Uncontrolled release of Ca2+ from the sarcoplasmic reticulum of skeletal muscle is the initiating event. Although the halogenated hydrocarbon anesthetics (e.g., halothane, isoflurane, and sevoflurane) and succinylcholine alone repoedly precipitate the response, most incidents arise from the combination of depolarizing blocking agent and anesthetic. Susceptibility to malignant hypehermia, an autosomal dominant trait Treatment: Intravenous administration of dantrolene (DANTRIUM), which blocks Ca2+release and its sequelae in skeletal muscle. Rapid cooling, inhalation of 100% oxygen, and control of acidosis should be considered adjunct therapy in malignant hypehermia
Succinylcholine
1120
Ether
Verapamil