A 40-year-old male comes to emergency with altered level of consciousness. On Examination, His BP 210/ 152 and has severe papilledema. Which of the following drug should be given by intravenous infusion and acts GPCR and is very sho acting?
Patient is likely having hypeensive emergency. All the drugs given in options except metoprolol can be used to control hypeensive emergencies. Fenoldopam Used in hypeensive emergencies Act on D1 receptors which are G protein coupled receptors. Very sho acting drug and must be given by intravenous infusion (being a catecholamine, not effective orally) Nitroprusside and hydralazine acts by releasing NO, which acts on intracellular guanyl cyclase. These do not act on GPCRs
Fenoldopam
Hydralazine
Metoprolol
Nitroprusside
Hypeension, Arrhythmias, Dyslipidemia