LEVOSIMENDAN acts on the all the following mechanism except ?
Molecular Targets Pharmacological Effects * Calcium sensitisation of the contractile * inotropy without increase of calcium transient and oxygen consumption apparatus by selective binding to calcium * Anti-stunning effect saturated cardiac troponin C * Opening of the ATP-sensitive potassium * Vasodilation (including coronary aeries) channels on the smooth muscle of the vasculature * increase of end-organ perfusion * Opening of the mitochondrial ATP- .Cardioprotection and organ protection Anti-ischaemic effect * sensitive potassium channels REF : KD TRIPATHI 8TH ED
phosphodiesterase inhibitor 3
neprilysin inhibitor
potassium channel opener
sensitizes myocardium to calcium channels
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