Which of the following tumors show increased -kit -
Ans. is 'd' i.e., Seminoma o C KIT or CDII 7 is a proto-oncogene, overexpression or mutations of this protein can lead to cancer. o Activating mutations in this gene are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism.
Yolk sac tumor
Embryonal carcinoma
Choriocarcinoma
Seminoma