Which is the most impoant prognostic marker in ALL?
Response to treatment is the most impoant prognostic marker in ALL. Leucocyte count> 50000/ul Poor prognosis Hyperploidy Favorable prognostic factor Response to treatment Remission status at 14 days of chemotherapy is best guide to prognosis. Organomegaly Poor prognosis. Lymph node, liver, spleen and testis enlargement indicate spread of cancer Unorable prognostic factors for ALL: Extreme age group: <1 year or >10 years Black males TLC>1 lac/cu.mm Organomegaly CNS Leukemia L2 ALL, pre B cell and mature B cell ALL Hypoploidy t(9:22) and t(4:11) Remission> 14 days
Leucocyte count >50000
Hyperploidy
Response to treatment
Organomegaly
AML & ALL