Gastrin is produced by
D. i.e. (Pyloric antrum) (443-Ganong 23rd) (484 - Ganong 22nd)* GASTRIN - is produced by cells called G-cells in the lateral walls of the glands in the antral portion of the gastric mucosa. It is polypeptide** containing* G-14, G-17 or G-34 amino acids. Found in pituitary gland, hypothalamus, medulla oblongata, vagus and sciatic nerves* SECRETIN is produced by S. cells of mucus membrane in duodenum and jejunum Stimuli that Increases gastrin secretion (a) luminal peptides and amino acids, Distension (b) Neural- increased vagal discharge via GRD (c) blood borne - calcium, Epinephrine Stimuli that inhibit gastrin secretion (a) Luminal acid, somatostatin** (b) Blood borne - secretin** GIP,VIP Glucagon**, Calcitonin* GASTRINOMA are gastrin producing tumours which can occur in stomach or duodenum or pancreatic tumour of d cells (Zollinger- Ellision Syndrome). These tumours secrete large amounts of gastrin which causes excessive secretion of HC1 and predisposes to peptic ulcer.
Greater sac
Lesser sac
First part of the duodenum
Pyloric antrum
G.I.T.