A newborn baby presented with profuse bleeding from umbilical stump after bih. Probable diagnosis is:
Congenital factor XIII deficiency is a rare autosomal recessive disease usually associated with a severe bleeding diathesis. Bleeding typically is delayed, because clots form normally but are susceptible to fibrinolysis. Umbilical stump bleeding is characteristic, and there is a high risk of intracranial bleeding. Replacement can be accomplished with FFP, cryoprecipitate, or a factor XIII concentrate. Ref: Gonzalez E.A., Jastrow K.M., Holcomb J.B., Kozar R.A. (2010). Chapter 4. Hemostasis, Surgical Bleeding, and Transfusion. In F.C. Brunicardi, D.K. Andersen, T.R. Billiar, D.L. Dunn, J.G. Hunter, J.B. Matthews, R.E. Pollock (Eds), Schwaz's Principles of Surgery, 9e.
Factor- XIII deficiency
VWF deficiency
Factor-XII deficiency
Glanzmann thrombasthenia