Dislufiram acts by blocking
DISULFIRAM is a DETERRANT which acts by blocking acetaldehyde dehydrogenase When acetaldehyde dehydrogenase is blocked there will be increased amount of acetaldehyde that acts on mast cells and results in release of histamine that in turn leads to allergic reaction. Thus when a patient on disulfiram takes alcohol there would be allergic reaction that prevents the patient from using the substance Ref.Kaplon and Sadock, synopsis of psychiatry, 11 th edition, Pg,No.625
Alcohol dehydrogenase
Acetaldehyde dehydrogenase
Pyruvate dehydrogenase
all of the above
Symptoms and signs in psychiatry and classification