Dantrolene sodium reduces skeletal muscle tone by:
* Dantrolene is the drug of choice for the treatment of malignant hypehermia and neuroleptic malignant syndrome. * It acts as an antagonist of Ryanodine receptors (present on smooth endoplasmic reticulum). It inhibits the release of Ca2+ from sarcoplasmic reticulum in the muscle fibre.
Reducing acetylcholine release from motor nerve endings
Suppressing spinal polysynaptic reflexes
Inhibiting the generation of muscle action potential
Reducing Ca2+ release from sarcoplasmic reticulum in the muscle fibre
Miscellaneous