Gastric carcinoma is associated with all EXCEPT:
ANSWER: (B) Overexpression of C-erbREF: Robbins 7thedition page 824, The diversity of gastric carcinoma: pathogenesis, diagnosis, and therapy by Michio Kaminishi, Kaiyo Takubo, Ken-ichi Mafune Page 55MOLECULAR STOMACH CARCINOGENESIS:p53 mutation commonly participates in early steps of stomach carcinogenesis.Amplification and overexpression of c-met and cyclin E genes are frequently associated with advanced stagesReduced expression of p27 participates in both the development and progression of gastric carcinoma.K-ras mutation, HER-2/c-erb/B2 amplification, and APC mutation preferentially occur in well-differentiated type.Inactivation of cadherin and catenins and amplification of K-sam and c-met are frequently associated with poorly differentiated with or scirrhous type carcinoma.
Inactivation of p53
Over expression of C -erb
Over expression of C-met
Activation of RAS