True about Dermatomyositis is?
Ans. is 'b' i.e., Bimodal age distribution * Although it can occur at any age; there is a bimodal distribution with peaks between age 10 & 15 years in children and between 45 & 60 years in adults.Important factors associated with dermatomyositis* It is the commonest type of inflammatory myopathy.* More common in females.* Associated with HLA types B8, B14 & DR3. Juvenile DM is associated with HLA DR3. Production anti-Jo-1 antibodies is strongly associated with HLA DR3.* DM is believed to be a microangiopathy affecting skin and muscles..* Other important factors associated with the causation of DM are drugs (Hydroxyurea, D-penicillamine, NSAIDs, phenytoin), silicone breast implants & bovine collagen implants.* Skin manifestation are often non-specific initially and commonly precede the onset of myositis by at least several months. They are precipitated by UV light.
Associated with HLA B27
Bimodal age distribution
No involvement of joints
Myopathy precedes skin lesions in most cases
Autoimmune Skin Disorders