A 6-year-old boy presents with acute abdomen and nonhealing ulcer on medial malleolus. Peripheral smear is shown. The most likely cause of this condition is?
Ref: Robbins, 8th ed. pg. 645-647Point mutation in 6th codon of b-globin that leads to replacement of glutamate by valine residue.
Trinucleotide repeat
Antibody to RBC membrane
Substitution of single amino acid base
Genomic imprinting
Blood