All of the following are examples for mechanism based inhibition, EXCEPT:
Mechanism-based inhibition/Suicidal inhibition: Suicidal inhibitors resemble the actual substrate of the enzyme. Enzymes binds to suicidal inhibitor & catalytic process is staed. In the process of catalysis, enzyme undergoes irreversible covalent modification by the inhibitor & active enzyme can't be regenerated. (Enzyme catalyses its own destruction) Suicidal Inhibitor Enzyme Allopurinol Xanthine oxidase Aspirin Cyclooxygenase 5-FU Thymidylate synthase Penicillin Transpeptidase Difluoromethylornithine Ornithine decarboxylase
Aspirin on cyclooxygenase
Allopurinol on Xanthine oxidase
Statins on HMG-CoA reductase
Difluoromethylornithine on ornithine decarboxylase
Enzyme basics and serine proteases