Which of the following feature may be used to differentiate hemophilia A from von Willebrand disease
Answer is A (Bleeding time) : Bleeding time is prolonged in von Willebrand disease, but normal in Hemophilia A Both conditions present with decreased levels of factor VIII normal PT and elevated PTT and hence these features cannot be used to differentiate between hemophilia A and von Willebrand disease. Features of VWF and differences with Haemophilia A Feature Hemophilia A Von Willebrand Disease Inheritance Sex linked Autosomal (Most common is A.dominant) Factor VIIIc Decreased Decreased VWF Normal Decreased Ristocetin cofactor Normal Decreased Common Presentation Features of clotting disorder Skin/Mucosal bleeding -- Hemahrosis ++ Features of bleeding disorder +- clotting disorder Skin/Mucosal bleeding + Hemohrosis+ Bleeding Time Normal Prolonged APTT Prolonged Prolonged (may be normal) PT Normal Normal Thrombin Time Normal Normal Fibrinogen Normal Normal Platelet aggregation in Response to Ristocetin Normal Decreased
Bleeding time
Prothrombin time
Paial thromboplastin time
Factor VIII levels