metaclopromide:
metaclopromide is aD2 receptor antagonist that increases cholinergic activity by inhibiting presynapyic D2 receptors in GIT . it increases LES tone that is also responsible for anti emetic action. it does not significantly increase colonic motility
inhibit cholinergic smooth.muscle stimulation in the gastrointestinal tract
decrease lower esophageal spinchter pressure
stimulate D2 receptor
enhance colonic activity
Gastrointestinal tract