Ammonia is toxic to the brain because it leads to depletion of which substrate?
Ans. B. Alpha ketoglutarateAmmonia reacts with Glutamate to form Glutamine. The Glutamate is formed from alpha keto glutarate an intermediate of TCA Cycle. So alpha ketoglutarate is depleted.
Succinate
Alpha ketoglutarate
Isocitrate
Fumarate
Proteins and Amino Acids