Which of the following is true about Anaplasia?
ANAPLASIA-It is the hallmark feature of malignant transformation. Metaplasia Change of epithelium types Benign & fully reversible Metaplasia | Dysplasia | Anaplasia Metastasis is hallmark feature of malignancy. Anaplasia is associated with many other morphological changes: Pleomorphism Abnormal nuclear pathology Mitoses Loss of polarity Areas of ischemic necrosis can be seen. When dysplastic changes are marked & involve full thickness of epithelium, but lesion does not penetrate B.M, it is considered CARCINOMA IN SITU. Once the T0 cells invade B.M, T0 is said to be INVASIVE. Dysplasia may be a precursor to malignant transformation, it does not always progress to cancer.
Loss of cohesion between cells
Loss of differentiation
Change of epithelium type
Benign and fully reversible
FMGE 2018