An obese woman with type 2 diabetes and hypeension is diagnosed with endometrioid type of endometrial carcinoma. The most likely gene defect in this patient is
Type 1 endometrial cancer is associated with PTEN gene. Type 2 endometrial cancer is associated with p53 gene mutation. Type 1 Endometrial cancer Type 2 Endometrial cancer 55-65 years 65-75 years Unopposed estrogen Obesity Hypeension Diabetes Atrophy Thin physique Endometroid Serous clear cell Hyperplasia Serous endometrial intraepithelial carcinomas Indolent Aggressive
P53
PTEN
MSH2
BRCA2
JIPMER 2017