All are true statements regarding use of sodium fluoride in the treatment of otosclerosis except:
Ans. is a i.e. It inhibits osteoblastic activity The most useful medication which prevents rapid progression of cochlear otoscierosis is sodium fluoride Mechanism of Action It reduces osteoclastic bone resorption and increases osteoblastic bone formation, which promote recalcification and reduce bone remodelling in actively expanding osteolytic lesion. It also inhibits proteolytic enzymes that are cytotoxic to cochlea and lead to SNHL (Hence specially useful in cochlear otosclerosis). Current Otolaryngology 2nd/ed pg 678
It inhibits osteoblastic activity
Used in active phase of otosclerosis when Schwaz sign is positive
Has proteolytic activity (bone enzymes)
Contraindicated in chronic nephritis