All of the following are features of physiologic jaundice, EXCEPT:
In physiologic jaundice, the rate of rise of bilirubin is less than 5 mg/dl. Other features are: jaundice visible after 24 hrs of age, total bilirubin of less than 15 mg/dl and disappearance of jaundice by 1 week in full term infant and 2 weeks in preterm infant. Physiologic jaundice occur due to Low UDPGT activity Relatively high red cell mass Absence of intestinal flora Slow intestinal motility Increased enterohepatic circulation of bilirubin in the first days of life. Ref: Thilo E.H., Rosenberg A.A. (2012). Chapter 2. The Newborn Infant. In W.W. Hay, Jr., M.J. Levin, R.R. Deterding, J.J. Ross, J.M. Sondheimer (Eds),CURRENT Diagnosis & Treatment: Pediatrics, 21e
Jaundice visible after 24 hrs of age
Rate of rise of bilirubin less than 3 mg/dl per day
Total bilirubin of less than 15 mg/dl
Disappearance of jaundice by 2 weeks in preterm infant