A 23-year-old woman presents with cervical and mediastinal lymphadenopathy. Biopsy of a cervical lymph node reveals a nodular appearance with fibrous bands, effacement of the lymph node architecture, and numerous lacunar cells. Which of the following is true regarding this disorder?
* The diagnosis is Hodgkin lymphoma, Nodular sclerosis subtype. Most common subtype of Hodgkin lymphoma (65% to 70% of cases) It is most commonly seen in young adults with similar incidence in males and females. Overall, this subtype has a relatively orable clinical course with prognosis better than other types of Hodgkin lymphoma. Association with EBV is uncommon and less frequent (10-25%) than in mixed cellularity CHL. Lacunar cells are considered a Reed Sternberg cell variant, and the diagnosis of nodular sclerosis can be based on the finding of nodules separated by collagenous/fibrous bands and lacunar cells. Lacunar cells are positive for CD15, CD30 and negative for CD20, CD45 (LCA). Image shows Lacunar cells -Image shows Nodular sclerosis
Benign neoplasm
Frequent association with EBV infection
Lacunar cells are positive for CD20 and CD45
Relatively orable clinical course
Hodgkin's Lymphoma