MRP2 gene defect results in which of the hereditary disorders of bilirubin metabolism and Transpo is:
PARAMETER Syndrome GILBE'S CRIGLER- NAJJAR TYPE I CRIGLER-NAJJAR TYPE II DUBIN-JOHNSON ROTOR'S Incidence 6%-12% Very rare Uncommon Uncommon Rare Gene affected UGT1A1 UGT1A1 UGT1A1 MRP2 Unknown Metabolic defect |Bilirubin conjugation No bilirubin conjugation ||Bilirubin conjugation Impaired canalicular expo of conjugated bilirubin Impaired canalicular expo of conjugated bilirubin Ref:Sleisenger and Fordtran's,E-9,P-326.
Gilbes
Crigler najjar type I
Crigler najjar type II
Dubin johnson-