The citric acid cycle is inhibited by which of the following?
Fluoroacetate can be conveed to fluorocitrate, which is an inhibitor of aconitase. Arsenic is not a direct inhibitor, but arsenite is an inhibitor of lipoic acid-containing enzymes such as a-ketoglutarate dehydrogenase. Malonate, not malic acid, is an inhibitor of succinate dehydrogenase. The citric acid cycle requires oxygen and would be inhibited by anaerobic, not aerobic, conditions. Fluorouracil is a suicide inhibitor of thymidylate synthase and blocks deoxythymidylate synthesis. Ref: Bender D.A., Mayes P.A. (2011). Chapter 17. The Citric Acid Cycle: The Catabolism of Acetyl-CoA. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds), Harper's Illustrated Biochemistry, 29e.
Fluoroacetate
Fluorouracil
Arsenic
Aerobic conditions