True about wound healing
• Epidermal appendages do not regenerate
• There remains a connective tissue scar in place of the mechanically efficient meshwork of collagen in the unwounded dermis.
• Very superficial wounds: Little scar formation.
• In marked contrast with wound healing in adults, fetal cutaneous wounds heal without scar formation, up to mid-gestation age in some animals. These wounds show little inflammation and practically no fibrosis.
Cutaneous wound healing is divided into three phases
• Inflammation (early and late)
• Granulation tissue formation and re-epithelialization
• Wound contraction, ECM deposition and remodeling
Infected wound heal by primary intention
Deep dermal wound heal by scar formation
Wound contraction is found in healing by secondary intention
More intense inflammatory response in primary intention