All of the folloiwng statements about meglitinides are true, except:
Ans is 'd' i.e. Act by decreasing insulin resistance o Though structurally unrelated to sulfonylureas, the meglitinides class of hypoglycemic drugs (Repaglinide and Nateglinide) bind to same ATP dependent K channels as do sulfonylureas and stimulate insulin secretion by closing these channels in pancreatic 13-cells-insulin secretogogue action. o The meglintinides are incapable of stimultating insulin secretion in nutrient-starved fl-cells but in the presence of glucose, they demonstrate hypoglycemic effects by augmenting the release of insulin. Consequently, meglitinides seem relatively unlikely to cause fasting hypoglycemia. o For the same reason, meglitinides effectively reduce post pradndial hyperglycemia as they demonstrate hypoglycemic effects in the presence of glucose.
Act by stimulating insulin release
Decrease postprandial hyperglycemia
Hypoglycemia is less common than with sulfonylureas
Act by decreasing insulin resistance