All of the following are true about Sickle cell disease, Except:
C i.e. 'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residueIn sickle cell anemia- Glutamic acid is replaced by valine at sixth position in /3 - globin chainQ.Sticky patch is generated as a result of replacement of polar residue (negatively charged glutamate amino acid) with a nonpolar hydrophobic residue (valine)Q. This change makes HbS (sickle cell hemoglobin) less soluble, when deoxygenated and cause sicklingQ.HbS confers resistance against malaria in heterozygotesQ.
Single nucleotide change results in change of Glutamine to Valine
RFLP results from a single base change
'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residue
HbS confers resistance against malaria in heterozygotes