Investigation of choice in Thiamine deficiency is
Severe thiamine deficiency is associated with: Decreased RBC transketolase activity this is the earliest manifestation seen even before clinical disturbances Thiamin is a cofactor of Transketolase pyruvate, alpha-ketoglutarate and lactate level in blood increases in thiamine deficiency ref: DM Vasudevan 8th ed page 467
RBC-Thiamine levels
RBC - Transketolase levels
RBC - Glutathione reductase levels
WBC - Ascorbic acid levels
vitamins