The key factor in the transpo of carbon dioxide as bicarbonate is
Since the Pco2 in the tissue is high,CO2 diffuses from tissues into the plasma. From there it enters the RBC which contains plenty of carbonic anhydrase. In blood,70% of CO2 is transpoed as HCO3 by the action of carbonic anhydrase. Reference:Textbook of medical physiology-Geetha N,2nd edition,page no:245.
The high solubility of CO2 in H20
The presence of Hb in blood
The presence of carbonic anhydrase in the erythrocytes
The acid nature of carbon dioxide and the alkaline nature of bicarbonate
Respiratory system