Man with gynaecomatsia and infeility, cause?
Cimetidine (but not other H2 blockers) has antiandrogenic action. It displaces dihydrotestosterone from its cytoplasmic receptor. It also increases plasma prolactin and inhibits degradation of estradiol by liver. High doses given for long periods have produced gynaecomastia, loss of libido, impotence and temporary decrease in sperm count leading to infeility. Reference : page 650 Essentials of Medical Pharmacology K D Tripathi 7th edition
Cimetidine
Omeprazole
Erythromycin
Digitalis
Endocrinology