Aminoglycosides are given in a single dose rather than thrice daily because of following reason?
Aminoglycosides exe Concentration Dependent Bactericidal action and Long Post-Antibiotic effect ,such that the antibacterial activity persists beyond the time during which measurable drug is present.Therefore higher plasma concentrations attained after the single daily dose will be equally or more effective than the divided doses and also convenient and cheaper. This is also to make sure that the plasma concentration remains low so as to not cause Ototoxicity and Nephrotoxicity. This allows washout of the drug from the Endolymph and the Renal coex.
Very long half life
Time Dependent Killing
Increased binding to plasma proteins
Long Post Antibiotic effect
Protein Synthesis Inhibitors