All of the following molecules/enzymes may contribute in generating free oxygen radicals within neutrophils for killing intracellular bacteria, except-
* Catalase, present in peroxisomes, catalyzes the decomposition of hydrogen peroxide (2H2O2 - O2 + 2H2O). It is one of the most active enzymes known, capable of degrading millions of molecules of H2O2 per second. *iNOS, the type that is involved in microbial killing, is expressed when macrophages are activated by cytokines (e.g., IFN-g)or microbial products, and induces the production of NO.
Nitric oxide
Fenton's reaction
NADPH oxidase
Catalase
Oxygen dependent bacterial killing