An elderly female presented with 'Peau de orange appearance' of breast. What is it likely to be associated with?
The orange skin or 'peau d 'orange' appearance is caused by swelling and oedema of the skin due to infiltration of dermal lymphatics, except at points where the dermis is anchored by these suspensory ligaments of the breast. This fibrous reaction is responsible for the spiculate features of a cancer. It is seen in chronic abscess and advanced breast cancer. Ref: Applied Basic Science for Basic Surgical Training edited by Andrew T. Raftery, 2008, Page 489; Bailey & Love's 25th edition, Page 844
Drug reaction
Obstruction of cutaneous lymphatics
Post operative scarring
Tumour necrosis