Sulfasalazine exes its primary action in ulcerative colitis by :
MOA* Inhibition of NF-KB Activation* Inhibition of PG synthesis* Scavenging of Free radicals 5-ASA compounds exe its local anti-inflammatory effect by inhibiting leukotriene production (PG synthesis) by inhibition of 5-lipooxygenase activity; also inhibits the production of IL-1 and TNF. Commonly Used 5-ASA Formulations in IBD Sulfasalazine Oral mesalamine agents Azo compounds: Balsalazide, Olsalazine
Folic acid synthesis
Formation of prostaglandins (PG)
Inhibition of NF-KB Activation
Formation of interleukins
Inflammatory bowel disease