All are true regarding Toxoplasmosis, except ?
Ans. is d i.e., Not infective in third trimester in pregnancy . The incidence of transplacental infection is highest in third trimester but the infant is not severely affected. . The presence of IgM (which does not cross placenta) in the infants circulation is diagnostic. Clinical manifestation of toxoplasmosis 1. Adults a) Immunocompetant host - Asymptomic in 90% of patients. - M.C. clinical featur is cervical lymphadenopathy. - Other less common manifestations are pneumonia, myocarditis, encephalitis. b) Immunocompromised host - M.C. signs and symptoms are principally within CNS Encephalopathy, Meningoencephalitis. 2. Children a) Congenital - May present with hydrocephalus, microcephaly mental retardation, deafness, blindness, epilepsy. - Intracerebral calcification may occur. b) Acquired - Mostly asymptomatic - C/Fs are chorioretinitis (most common), cataract, glaucoma.
Subclinical in most cases among adults
Intracerebral calcification in children
IgM antibody in new born suggests congenital infection
NOT infective in 3" trimester in pregnancy