Among the following true about linezolid except
OXAZOLIDINONE Linezolid:- Mech of action:- Linezolid inhibits bacterial protein synthesis by acting at an early step and a site different from that of other AMAs. It binds to the 23S fraction (P site) of the 50S ribosome and interferes with formation of the ternary N-formylmethionine- tRNA (tRNAfMet) -70S initiation complex. Binding of linezolid distos the tRNA binding site overlapping both 50S and 30S ribosomal subunits and stops protein synthesis before it stas. uses:- Used in treatment of resistant gram-positive coccal (aerobic and anaerobic) and bacillary infections. It is active against MRSA and some VRSA, VRE, penicillin-resistant Strep. pyogenes, Strep. viridans and Strep. pneumoniae, M. tuberculosis, Corynebacterium, Listeria, Clostridia and Bact. fragilis. It is primarily bacteriostatic, but can exe cidal action against some strepto-cocci, pneumococci and B. fragilis. Gram- negative bacteria are not affected. Ref:- kd tripathi; pg num:-758
It inhibits bacterial protein synthesis at an early step
It is active against vancomycin resistant enterococci
It can be administered orally as well as by i.v. infusion
It is the drug of choice for enterococcal endocarditis
Antibiotics