What is prodrug
A. i.e. (Inactive drug convert into active metabolites) (23- 24- KDT 6th)Few drugs are inactive as such and need conversion in the body to one or more active metabolites. Such a drug is called PRODRUGAdvantages1. More stable2. Better bioavailability3. Less side effects and toxicityPOTENCY - a measure of the amount of drug necessary to produce an effect of a given magnitude* EC50 is the concentration of the drug that produce a response equal to 50% of the maximal response* The potency of the drug can be compared using EC50, the smaller the EC50, the more potent the drug
Inactive drugs convert into active metabolites
Active drugs converts into inactive metabolite
Measure of the amount of drug necessary to produce an effect of a given magnitude
Bind to a receptor and elicit a biologic response
General Pharmacology