Which of the following characteristics make metformin a preferred biguanide than phenformin?
(Ref: KDT 6/e p269) Incidence of lactic acidosis is more with phenformin and that of megaloblastc anemia (due to interference with vitamin B12 absorption) is more with metformin.
It is more potent
It is less liable to cause lactic acidosis
It does not interfere with vitamin B12 absorption
It is not contraindicated in patients with kidney disease
Other topics and Adverse effects