A 14-year-old boy is brought to OPD with c/o increasing weakness, easy fatigability, and weight loss over the past 3 months. In addition, he has recently developed nausea, vomiting, and abdominal pain. His blood pressure is markedly decreased, and he has increased pigmentation of his skin creases. These findings are suggestive of
- The clinical findings are suggestive of Addison disease (primary adrenocoical insufficiency). - MCC cause - Tuberculosis ; Autoimmunity - Hyperpigmentation in Addison disease results from compensatory hypothalamic production of pro-opiomelanocoin, precursor peptide of both coicotropin & melanocyte-stimulating factor
Cushing syndrome.
Secondary hyperaldosteronism
Osteitis fibrosa cystica
Addison disease.
Adrenal Gland