Most commonly associated mutation in prostratic carcinoma is?
Harshmohan textbook of pathology 7th edition. prostatic carcinoma- at genetic level following epigenetic phenomenon and acquired somatic mutation have been repoed in development of prostatic carcinoma. 1. Epigenetic phenomenon- hyper methylation of GSTP 1 gene promoter causing loss of function of the gene that detoxifyes carcinogens. .
p16\/INK4a
PTEN
GPST 1
APC
General pathology