All of the following are true regarding clofazimine except
Clofazimine (Clo) It is a dye with leprostatic and antiinflammatory propeies. Mechanism of action of clofazimine:- * Interference with template function of DNA in M.leprae * Alteration of membrane stucture and its transpo function. * Disruption of mitochondrial electron trans po chain. Clofazimine is used as a component of multidrug therapy (MDT) of leprosy. Because of its antiinflammatory propey, it is valuable in lepra reaction. PHARMACOKINETICS Clofazimine is orally active (40-70% absor bed). It accumulates in macrophages and gets deposited in many tissues including subcutaneous fat, as needle-shaped crystals. However, entry in CSF is poor. The t 1/2 is 70 days so that intermittent therapy is possible Adverse effects:- Skin:- The major disadvantage is reddish-black discolouration of skin, especially on exposed pas. Discolouration of hair and body secretions may also occur. Dryness of skin and itching is often troublesome. Acneform eruptions and phototoxicity have been noted. Conjunctival pigmentation may create cosmetic problem. Ref:- kd tripathi; pg num:-781,782
It is cidal to Mycobacterium leprae
It has a very long elimination half life
It discolours skin and sweat
It has additional antiinflammatory propey
Antibiotics