All of the following statements concerning CO2 transpo are TRUE, EXCEPT:
The solubility of CO2 in blood is twenty times that of O2, and thus a small but considerable poion of CO2 is dissolved in blood (5%). The bulk of CO2 transpo involves its reversible combination with water. This occurs rapidly enough because of the action of carbonic anhydrase, an enzyme located inside RBCs. As bicarbonate ion diffuses out of RBCs, chloride ions diffuse in according to Gibbs-Donnan equilibrium. Combination of CO2 with amine groups, especially those of hemoglobin, also accounts for a significant poion of CO2 transpo (5%). Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 35. Gas Transpo & pH. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds),Ganong's Review of Medical Physiology, 24e.
Compared to O2, dissolved CO2 plays a significant role in its transpo
The bulk of CO2 transpo involves reversible combination of CO2 with water in red blood cells
CO2 is rapidly conveed to bicarbonate anions in plasma
Chloride ions enter red blood cells in exchange for bicarbonate anions