What is the best preventive measure for neural tube defects?
Ans. is 'b' i.e., Folate supplementation to mother Neural tube defectso NTDs account for most congenital anomalies in CNS. It results from failure of neural tube to close spontaneously between 3rd-4th week of in utero developmento NTDs have multiple etiological factors :-# Maternal diabetes# Maternal exposure to alcohol, radiation, valproate, carbamazepine# Zinc and folate deficiency# Trisomy 13 and 15# Maternal malnutrition is an important risk factor for development of NTD. There is decreased maternal folatelevels in NTD affected pregnancies. Periconceptional folic acid supplementation decreases the occurrence of NTDo NTDs allow excretion of fetal substances like alpha-fetoprotein and acetylcholinesteraseinto amniotic fluid, which are used as prenatal biochemical markers for diagnosis
Vitamin B12 supplementation to mother
Folate supplementation to mother
BCG vaccination at birth
USG in 2nd trimester
Congenital Anomalies of the CNS