Arsenic is useful in the treatment of:
Arsenic has been a traditional poison for ages. Recently,therapeutic value of small doses of arsenic trioxide in APL has been recognised.It probably acts by enhancing reactive oxygen free radical generation in APL.It is primarily used in resistant/relapsed cases of APL after tretinoin treatment.Later ,Arsenic trioxide is also being included in first line therapy of APL along with tretinoin and an anthracycline,paicularly in high risk cases and in those who have initial WBC count > 10,000 per microlitre.With such triple therapy around 90% APL patients have remained in long term remissions. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SEVENTH EDITION PAGE NO:869
Acute promyelocytic leukemia
Myelodysplastic syndrome
Transient myeloproliferative disorder
All of the above
Chemotherapy