True about WIC ?
Ans. is 'c' i.e., Class HI has complement MHC gene is present on sho arm of chromosome 6. Class II comprises DR, DQ, DP regions (A, B, C loci are present on class I). Class III consists of complement components. Mixed leukocyte reaction involves class II MHC. The histocompatibility antigens (human leukocyte antigens - HLA) are cell surface antigens that induce an immune response leading to rejection of allografts. The principal physiologic function of the cell surface histocompatibility molecules is to bind peptide fragments of foreign proteins for presentation to antigen specific T cells. The histocompatibility antigens are encoded by a closely linked multiallelic cluster of genes --/ Major histocompatibility complex (MHC) or Human leukocyte antigens complex (HLA complex). HLA complex of genes is located on the sho arm of chromosome 6.
Present on chromosome 4
Class II comprises A, B, C loci
Class III has complement
Class I is involved in mixed leucocyte reaction