All of the following statements about methotrexate are true EXCEPT:
Folinic acid (leucovorin) is used to reverse the adverse effect of methotrexate. Folic acid is ineffective. All other statements are true
It is cell cycle specific and kills cells in the S phase
Its toxicity primarily affects bone marrow and epithelial structures
Folic acid reverses its toxic effects
It is the drug of choice for choriocarcinoma
Cytotoxic Anticancer Drugs