Severe Laxity of joints -
Marfan syndrome (MFS) is a genetic disorder of the connective tissue. The degree to which people are affected varies. People with Marfan tend to be tall and thin, with long arms, legs, fingers and toes. It involves a mutation to the gene that makes fibrillin, which results in abnormal connective tissue Ref Davidson 23rd edition pg 712
Marfan's syndrome
EhlerDanlos
RA
Osteogenesis imperfecta
Miscellaneous