Microsomal enzyme induction with alcohol, warfarin and phenytoin results in ceain changes in the liver biochemistry. What are the specific changes associated with this effect?
Sustained elevation in GGT ALP is seen with phenytoin, alcohol, warfarin and rifampicin is seen due to induction of hepatic CYP enzymes and this phenomenon is often referred to microsomal enzyme induction. Ref : Schiff's diseases of liver, Edition -11 , Page - 715.
Transient steatohepatitis
Granulomatous changes
Transient elevation in bilirubin and transaminase
Sustained elevation in GGT and ALP