What is the biochemical defect in the Zellweger syndrome?
Ans. A. Peroxisomal biogenesis disorderBiochemical defect in Zellweger SyndromeThere is gene defects, involving mainly the import of proteins that contain the PTS1 targeting signal* Zellweger syndrome (most severe)Clinical picture* Typical facial appearance (high forehead, unslanting palpebral fissures, hypoplastic supraorbital ridges, and epicanthal folds)* Severe weakness and hypotonia, neonatal seizures* Eye abnormalities (cataracts, glaucoma, corneal clouding, Brushfield spots, pigmentary retinopathy, and nerve dysplasia)* Because of the hypotonia and "mongoloid" appearance, Down syndrome may be suspected
Peroxisomal biogenesis disorder
Lysosomal targeting disorder
Defect in glycosylation of proteins
Trisomy 21
Lipids