Increased deposition of fat in liver in a patient with alcoholism is due to all except:
(A) Increased catabolism of fat peripherally # Alcoholic Fatty Liver: Fatty liver is the most frequent hepatic abnormality found in alcoholics. It is a toxic manifestation of ethanol ingestion, appearing within three to seven days of excess alcohol intake. Metabolic changes associated with ethanol ingestion result in increased triglyceride synthesis, decreased lipid oxidation and impaired secretion by the liver.> This results in the accumulation of triglycerides in the hepatocytes, mainly in the terminal hepatic venular zone. In more severe cases, the fatty change may be diffuse.> Fat tends to accumulate as macrovesicular (large droplets), rather than microvesicular (small droplets), which represents mitochondrial damage. Fatty liver may occur alone or be part of the picture of alcoholic hepatitis or cirrhosis
Increased catabolism of fat peripherally
Decreased fatty acid oxidation
Increased triglyceride synthesis
Accumulation of triglycerides in the terminal hepatic venular zone
Miscellaneous (Bio-Chemistry)