Cilastatin is given in combination with Imipenem because:-
Carbapenems are synthetic Beta lactam antibiotic. Imipenem is compounded with cilastatin to protect it from metabolism by renal dehydropeptidase. Cilastatin is a dehydropeptidase inhibitor. High level of imipenem may provoke seizure, however other carbapenem like:- Meropenem Eapenem Doripenem Are less likely to do
Cilastatin prevents degradation of Imipenem in kidney
Cilastatin increase absorption of Imipenem
Inhibits the enzymes that digest Imipenem in stomach
Reduces side effects of Imipenem
NEET 2019