Bioavailability of Ramelteon is?
Reference: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed., Pg. 1972.
Ramelteon is rapidly absorbed orally, undergoes extensive first pass metabolism in liver, so that bioavailability is low (F = 1.8%) and elimination t½ is 1–3 hours.
2%
7%
10%
30%