Function of inhibin:
Ans. d. Inhibin-A decreases in trisomy 18 (Edwards syndrome)Inhibin A/B is useful tumor marker for Granulosa cell tumors.FSH binds to Sertoli cells and activates a Gs --cAMPpathway. Sertoli cellsRelease inhibin B, which has negative feedback on FSH secretion.Trisomy 21 with down syndrome, levels for MS-AFP and estriol are decreased, but hCG and inhibin-A are, increased. Perform an amniocentesis for karyotype.Trisomy 18 With Edward syndrome, levels for all 4 markers (MS-AFP, estriol, inhibin-A, and hCG) are decreased. Perform an amniocentesis for karyotype.
Inhibin A/B is useful tumor marker for Sertoli-Leydig tumors.
Inhibin-B Produces positive feedback for FSH
Inhibin-A decreases in trisomy 21 (Down syndrome)
Inhibin-A decreases in trisomy 18 (Edwards syndrome)
Physiology & Histology