In giant cell tumor of the bone.,the cell of origin is
The Neoplastic cells of giant cell tumor are primitive osteoblast precursors but they represent only a minority of the tumor cells.The bulk of the tumor consists of non Neoplastic osteoclast and their precursors Ref Robbins page no 1203
Fibroblst cells
Osteoclast and precursors
Osteoblast and precursors
Sinusoidal cells
Musculoskeletal system