Which of the following is not seen in Weil disease?
Ans: d (Lung involvement) Ref: Davidson, 20th ed, p. 321; 19th ed, p. 20; Harrison, 16th ed,p. 990Weil disease (Icteric Leptospirosis)It is characterized by fever, haemorrhages, jaundice and renal impairment. In Davidson lung involvement in not mentioned as a feature of Weil disease.But in Harrison it is mentioned that pulmonary involvement is a frequent manifestation in some clusters of cases. Fever, jaundice and renal failure are mentioned as clinical features of Weil disease in bothHarrison and Davidson but since lung involvement is not mentioned in Davidson. (We have opted for this choice)Most pathogenic serotype of leptospira is L. icterohemorrhagicaLeptospirosisIt is a zoonosis.The organism survives in the convoluted tubule of animal hosts kidney & shed in urineOrganism enter the host body through cut skin or intact mucosa of mouth nose or conjunctiva.Leptospirosis (Weil disease) IP 10 days-- Hepatorenal failure, jaundice. -- Pyrexia --Bleeding diathesis(Albuminuria is a constant feature)* Aseptic meningitis more common in L. canicola infectionDiagnosis:1. Demonstration of leptospira - blood, CSF- in the first week-urine- 2nd week to 6th week (best in 2-3 weeks)2. Serological diagnosis-antibodies by end of lsl week, increase till 4th week then declines - microscopic agglutination test (MAT) -type specific3. Animal inoculation; intraperitoneal inoculation in Guinea pigs & culture of the heart blood collected 10 min later.Prophylaxis: DoxycyclineTreatment: DOC is penicillin.
Fever
Jaundice
Renal failure
Lung involvement
Infection