Histology of Alpo syndrome-
Alpo syndrome: EM is diagnostic and shows "basket weave appearance" of the GBM. Alpo syndrome: Hereditary nephritis Abnormal a3 (COL4A3), a4 (COL4A4), or a5 (COL4A5) chain of type IV collagen Hematuria with progression to chronic renal failure Nerve deafness Eye disorders Foamy cells in the interstitium. Ref: RAM DAS NAYAK EXAM PREPARATORY MANUAL FOR UNDERGRADUATES 2nd ed. pg no: 612
Foamy cells in interstitium
Foamy cells in tubular epithelial cells
Thickening of GBM > 100 nm
Thinning of GBM < 100 nm
Urinary tract