Calorie restriction increases longevity through -
Siuins are a family of proteins that play a role in aging by regulating cellular health. They're responsible for critical biological functions like DNA expression and aspects of aging. However, siuins can only function in the presence of NAD+, nicotinamide adenine dinucleotide, a coenzyme found in all living cells. Ref Harrison 20th edition pg 78
Siruins
Albumin
Amyloid
Carotene
Nutrition