40 year old patient presented with excessive skin pigmentation of face neck and extensor aspects of forearms having diabetes and ahropathy and Dyspnoea on exeion, class III. Clinical examination revealed hepatosplenomegaly and spider angioma. All are true about this condition, except:
The diagnosis is hemochromatosis. Major manifestations of haemocromatosis are cirrhosis, diabetes, ahritis, cardiomyopathy, hypogonadism. Males are commonly involved than females, as females have regular mentraul periods where there is a blood loss.
Caused by a mutant gene termed HFE
Risk of hepatocellular carcinoma is very high
Females are commonly affected
The most common cardiac manifestation is CCF