A major causal factor in some cases of hypogonadism is
Reduced secretion of GnRH will result in extremely low levels of circulating LH and FSH, causing testicular atrophy, as in Kallmann's syndrome.
Reduced secretion of gonadotropin-releasing hormone (GnRH)
Hypersecretion of pituitary LH and FSH as the result of increased GnRH
Excess secretion of testicular activin by Seoli cells
Failure of the hypothalamus to respond to testosterone
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