Ergot alkaloids are used in all except -
Ans. is 'c' i.e., Hypertension Uses of ergot alkaloids1. Migraineo In migraine, throbbing headache is due to dilatation of pain sensitive arteries outside the brain, i.e. extracerebral vessels.o Ergot alkaloids are vasoconstrictor (due to a agonistic action) and oppose these effects,o Ergot alkaloids used in migraine -Prophylaxis-MethysergideAcute attack-Ergotamine & dihydroergotamine2. Parkinsonismo In parkinsonism, there is degeneration of dopaminergic neurons.o Bromocriptine; an ergot alkaloid, is dopamine agonist at D2 receptor - can be used in parkinsonism.3. Hyperprolactinemiao Prolactin is under predominant inhibitory control of hypothalamus through dopamine that act on receptor of pituitary lactotroph.o Bromocriptine by D2 agonistic activity, decreases prolactin secretion.4. Acromegalyo Dopamine increases GH release in normal subjects but decreases it in acromegalics,o Bromocriptine also acts in same way due to its dopamine agonistic action.5. Dementiao Dihydroergotoxin increases cerebral blood flow and act by protecting altered brain metabolism.
Migraine
Acromegaly
Hypertension
Parkinsonism
C.N.S