A young male patient presented with prolonged bleeding time. You take a detailed history and ask the patient for intake of NSAIDs as these can prolong the bleeding time. The patient refuses the intake of any form of NSAIDs. No other drug history was obtained. All of the following drugs can prolong bleeding time except
Ans. (B) Multivitamins containing Vitamin K(Ref: Goodman and Gilman 12/e p1806)Vitamin K is involved in activation of clotting factors II, VII, IX and X. It thus, decreases the risk of bleeding.
Cephalosporins
Multivitamins containing Vitamin K
Methylxanthines
Anti-depressants
Antiplatelets and Fibrinolytics