Metyrosine given in:
Ans. a. Malignant pheochromocytomaRef: Goodman Gilman 13th E/P141Metyrosine competitively inhibits tyrosine hydroxylase, thereby decreasing norepinephrine synthesis in the neurons.It is used for treatment of hypertension in patients with pheochromocytoma prior to surgery along with phenoxybenzamine, which is the drug of choice.It is also used in malignant pheochromocytoma for long term management.
Malignant pheochromocytoma
Addisons disease
Depression
Hypertensive emergency
A.N.S.