Which vitamin is required for the rate-limiting step of heme synthesis:
The rate-limiting step of heme synthesis is catalysed by ALA synthase This condensation reaction requires Pyridoxal phosphate (Vitamin B6) as a cofactor. This is why vitamin B6 deficiency leads to sideroblastic anemia.
Vitamin B1
Vitamin B2
Vitamin B3
Vitamin B6
HAEM synth and porphyrias