Initiating event of Endotoxic shock
The receptor for the endotoxin in humans is the TLR-4 located on the surface of antigen presenting cells. b. Binding to the receptor activates a cascade of enzymatic reactions which finally leads to the activation of the genes for the proinflammatory cytokines. Ref ganong's review of medical physiology 25e p465
Endothelial injury
Peripheral vasodilata on
Cytokinin action
Decreased pumping of hea
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