100 % bioavailability is seen with which route
• Bioavailability is defined as the fraction of unchanged drug reaching the systemic circulation following administration by any route.
In case a drug is given orally, the bioavailability shall be less than 100%. This is due to
■ The incomplete extent of absorption
■ First pass metabolism
Routes of Administration, Bioavailability, and General Characteristics
Oral
Intravenous
Rectal
Subcutaneous