Rate limiting step in heme synthesis is catalyzed by ?
Synthesis of heme Heme synthesis takes place in all cells, but occurs to greatest extent in bone marrow and liver.The first step in the synthesis of heme is the condensation of glycine and succinyl Co-A to form &-aminolevulinic acid (6-ALA), which occurs in mitochondria.This reaction is catalyzed by 6-ALA synthase which requires pyridoxal phosphate (PLP) as cofactor.This is the rate limiting step in heme synthesis.
ALA dehydratase
ALA synthase
UPG decarboxylase
Ferrochelatase