Which of the following is feature of arsenic toxicity?
Ans. b (Non-cirrhotic portal fibrosis)> C. HCC. (Ref. Robbin's pathology, 7th ed., pg 907; Table 18-8)Hepatocellular damageExamplesAngiosarcomaVinyl chlorideNCPFArsenicMicrovesicular fatty changeTetracycline, salicylates yellow phosphorus, ethanolMacro vesicu lar fatty changeEthanol, methotrexate, amiodaroneCentrilobular necrosisBromobenzane, CCI4, acetaminophen, halothane, rifampinDiffuse or massive necrosisHalothane, isoniazid acetaminophen, methyldopa, trinitrotoluene,Amanita phylloides (mushroom) toxinHepatitis, acute and chronicMethyldopa, isoniazide, nitrofurantoin, phenytoin, oxyphenisatinFibrosis-cirrhosisEthanol, methotrexate, amiodarone, most drugs that cause chronic hepatitisGranuloma formationSulfonamides, methyldopa, quinidine, phenylbutazone, hydrala zine, allopurinolCholestasis (with or without hepato cellular injury) contraceptives, organic arsenicalsChlorpromazine, anabolic steroids, erythromycin estolate, oralContraceptives, organic arsenicals
Cirrhosis of liver
Non-cirrhotic portal fibrosis
Hepatocellular carcinoma
Hepatoma
Liver & Biliary Tract