A patient on cisplatin therapy develops intractable vomiting on the third day of treatment. Agent of choice for controlling this vomiting is:
(Ref: Katzung 10/e p1027, 1028) Cisplating induced vomiting has two phases. Early Phase: It occurs within first 24 hours. 5HT3 antagonists like ondansetron are the agents of choice for this condition. Delayed Phase: Vomiting occurring ater 24 hours is less responsive to ondansetron and other drugs. It is best controlled by substance Pantagonist like aprepitant.
Aprepitant
Ondansetron
Metoclopramide
Prochlorperazine
Other topics and Adverse effects