In inflammatory process ,the prostaglandins E1and E2 cause
Ref Robbins 9/e p85 It is a direct vasodilator, relaxing smooth muscles, and it inhibits the release of noradrenaline from sympathetic nerve terminals. It does not inhibit platelet aggregation, where PGI2 does. PGE2 also suppresses T cell receptor signaling and may play a role in resolution of inflammation. Up-regulation of PGE2 has been implicated as a possible cause of nail clubbing. Fuhermore, its postpaal synthesis in newborns is considered as one cause of patent ductus aeriosus
Vasodilation
Increased gastric output
Decreased body temperature
Vaso constriction
General anatomy