Non specific esterase is positive in all the categories ofANIL except-
Ans. is 'd' i.e., M6 FAB classification divides AML into eight types Mo to M7. This scheme takes into account. (i) The degree of maturation (Mo to M.,) (ii) The lineage of leukemic blast (M4 to M7) Class Mo minimally differentiated AML M1 AML without differentiation 1 M2 AML with maturation M3 Acute promyelocytic leukemia M4 Acute myelomonocytic leukemia M5 Acute monocytic leukemia M6 Acute erythroleukemia M7 Acute megakaryocytic M2 is the most common type ofAML. M7 is the least common type ofAML Blast cells Myeloperoxidase negative Auer rods negative Express myeloid lineage antigen 3% blasts myeloperoxidase positive Auer rods positive Full range of myeloid maturation Myeloperoxidase positive Auer rods positive Maximum Auer rods Myeloperoxidase positive Both myelocytic & monocytic differentiation o Myeloperoxidase (+)ve o Auer rods (+)ve Myeloblastic o Nonspecific esterase (+) ve --> Monoblastic Nonspecific esterase (+)ve Myeloperoxidase & Auer rods (-)ve. Dysplastic erythroid precursors Myeloblasts seen in advanced, age Blasts, of megakaryocytic lineage o GP Ilb/II la or VWF (+)ve.
M3
M4
M5
M6