First line treatment of T315I mutation in CML management is?
T315I mutation is a mutation in the critical BCR-ABL kinase in the ATP-binding pocket This prevents imatinib binding and hence leads to resistance to imatinib, nilotinib, bosutinib, and dasatinib. Only drug effective for T315I mutation CML = Ponatinib. Otherwise DOC CML= Imatinib. DOC for Imatinib resistant CML = Bosutinib DOC in case of failure of > 2 Tyrosine kinase inhibitor = OMACETAXINE
Bosutinib
Tofacitinib
Ponatinib
Nilotinib
CLL & CML