True regarding ondansetron are all of the following except: March 2010
Ans. C: Significant Drug Interactions Ondansetron is the prototype of new class of antiemetic drugs developed to control chemotherapy/radiotherapy induced vomiting, and later found to be highly effective in postoperative nausea and vomiting as well. It blocks the action of 5-HT through 5-HT3 receptors on vagal afferents in the GIT as well as in NTS and CTZ. A minor 5-HT4 antagonistic action has also been shown. It is hydroxylated by CYP 1A2, 2D6 and 3A, but no clinically significant drug interactions have been noted.
Antiemetic of choice for chemotherapy induced vomiting
5-HT3 receptor antagonist
Significant drug interactions
May have 5-HT4 antagonism