Guddu, a 5-year-old female was brought to the emergency with fever, headache and confusion. A provisional diagnosis of bacterial meningitis was made. The baby developed a severe allergic reaction to penicillin aroud six months back. She was admitted and intravenous antibiotics were staed. Few days later her investigations revealed as: Hemoglobin 6.0 g/L Erythrocyte count 1.2 x 106/mm3 Platelets 60000/mm3 Leukocyte count 1500/mm3 Which of the following is the most likely drug responsible for the above findings?
The patient's shows decreased erythrocytes, leukocytes, and platelets. It occurs due to suppression of stem cell function in the bone marrow. Chloramphenicol can cause both dose-dependent and dose-independent aplastic anemia. Dose-dependent aplastic anemia associated with chloramphenicol is reversible after the medication is withdrawn. Dose-independent anemia is usually severe and may be fatal.
Gentamicin
Chloramphenicol
Doxycycline
Vancomycin
Antimicrobial Drugs