Metoclopramide acts to achieve which of the following
PROKINETIC DRUGS Metoclopramide Mech of action on GIT:- Metoclopramide has more prominent effect on upper g.i.t.; increases gastric peristalsis while relaxing the pylorus and the first pa of duodenum - speeds gastric emptying.This action is independent of vagal innervation, but is stronger when vagus is intact. Lower esophageal sphincter (LES) tone is increased and gastroesophageal reflux is opposed. It also increases intestinal peristalsis to some extent, but has no significant action on colonic motility and gastric secretion. Ref:- kd tripathi; pg num:-664
Decrease lower esophageal sphincter pressure
Decrease transit through the small intestine
Stimulate vomiting
Increase gastric emptying
Gastrointestinal tract