Howell-jolly bodies are seen in: September 2005
Ans. C: Both of the above Howell-Jolly bodies are histopathological findings of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow erythrocytes normally expel their nuclei, but in some cases a small poion of DNA remains Howell-Jolly bodies are present in some red cells due to asplenia. Common causes of asplenia are splenectomy due to trauma and autosplenectomy caused by sickle cell anemia.
Sickle cell anemia
Splenectomy
Both of the above
None of the above