Which of the following increases the susceptibility to coronary aery disease?
Patients with nephrotic syndrome develop hyperlipidemia and hypercholesterolemia, secondary to increased hepatic synthesis of lipoproteins and decreased clearance of lipoproteins from the circulation. Hyperlipidemia in these patients also cause systemic atherosclerosis. Marked reduction of HDL receptor protein expression also contribute to increased atherosclerosis. All of these, acts as predisposing factors for the development of coronary aery disease. Ref: Heptinstall's Pathology of The Kidney, Volume 1 By J. Charles Jennette, Page 132; Therapy of Renal Diseases and Related Disorders By Wadi N. Suki, 2nd Edition, Chapter 321; Current Medical Diagnosis and Treatment, 2012, Chapter 22.
Nephrotic syndrome
Von willebrand disease
Type V hyperlipoproteinemia
Systemic lupus erythematosus