Cholesterol present in LDL :
C i.e. On accumulation in the cell inhibits replenishment of LDL receptors.
Represents primarily cholesterol that is being removed from peripheral cells.
Binds to a receptor and diffuses across the cell membrance.
On accumulation in the cell inhibits replenishment of LDL receptors.
When enters a cell, suppresses activity of acyl-CoA: cholesterol acvtranferase ACAT.