Treatment of choice for severe falciparum malaria is:
Intravenous or intramuscular aesunate is the treatment of choice in severe malaria. Quinine can be used when aesunate is not available. Aemether by intramuscular route is acceptable as an alternative in the treatment of severe falciparum malaria during an epidemic. Ref: Harrison's 17th/1288, 1289; Harrison's Self Assessment & Review (17th) /104/Q iv-7; Guidelines for the treatment of malaria By World Health Organization 2nd edition page 17 and 57; Essentials of medical pharmacology by KD Tripathi 5th edition/page 747-8.
Chloroquine
Intravenous aesunate
Intravenous quinine
Intravenous quinidine