TRUE about sepsis related acute kidney injury is:
AKI complicates more than 50% of cases of severe sepsis. Decreases in GFR with sepsis can occur even in the absence of ove hypotension Tubular injury associated with AKI in sepsis as manifest by the presence of tubular debris and casts in the urine. The hemodynamic effects of sepsis--arising from generalized aerial vasodilation, mediated in pa by cytokines that upregulate the expression of inducible NO synthase in the vasculature can lead to a reduction in GFR. Ref: Harrison-E-18, P-2294.
AKI seen in 20% cases of severe sepsis
Ove hypotension is the cause of decreased GFR
Tubular injury is manifested by tubular debris and casts in urine
Generalised aerial vasoconstriction is present