Treatment with anti-hypeensive drug spironolactone leads to formation of spironolactone bodies in:
Aldosterone-producing adenomas Solitary, small (<2 cm in diameter), well-circumscribed lesions Bright yellow on cut section and, surprisingly, are composed of lipid-laden coical cells that more closely resemble fasciculata cells than glomerulosa cells (the normal source of aldosterone). Hallmark feature is presence of eosinophilic, laminated cytoplasmic inclusions, known as spironolactone bodies, found after treatment with the antihypeensive drug spironolactone. Do not suppress ACTH secretion. Adjacent adrenal coex and that of the contralateral gland are not atrophic.
Adrenal coex
Adrenal medulla
Renal coex
Renal medulla
Adrenal Gland