Mutations in COL 4A5 gene manifests as -
Ans. is 'a' i.e., Alport's syndrome o Manifestations of Alport's syndrome are due to abnormal a} (COL4A3), OC4 (COL4A4), or a. (COL4A5).o This is due to mutations of:i) COL4 A5 in classic X-linked formii) COL4A3 or COL4A4 in autosomal forms.
Alport's syndrome
HNPCC
Good pasture
Vitiligo
Mendelian Disorders: Single-Gene Defects