Mechanism of action of actinomycin D is ?
Ans. is 'a' i.e., Inhibits DNA dependent RNA synthesis The anticancer antibiotics are Actinomycin - D (Dactinomycin) Daunorubicin (Rubidomycin) Mitomycin C Doxorubicin Mitoxantrone Mithramycin (plicamycin) Bleomycins These anticancer, antibiotics obtained from micro-organisms and have prominent antitumour activity. Mechanism of action : They are intercalated between DNA strands and interfere with its template function. Actinomycin `D' inhibits DNA dependent RNA synthesis. Bleomycin cause DNA breakage and free radical formation . Doxo-and daunorubicin inhibit Topoisomerase I & II. Mitomycin acts like alkylating agents. Mitoxantrane binds to DNA to produce strand breakage and inhibits both DNA & RNA synthesis. Remember All antitumor antibiotics are cell cycle nonspecific except for bleomycin which acts in G2 phase.
Inhibits DNA dependent RNA synthesis
Activates DNA dependent RNA synthesis
Inhibits RNA dependent DNA synthesis
Activates RNA dependent DNA synthesis