Increasing severity of mental retardation of male members over generations is a result of -
Ans. (d) Trinucleotide repeat mutation(Ref: Robbins 9th/pg 168-171; 8th/pg 168-171)Increasing severity of mental retardation of male members over generations is a result of "anticipation", seen in disorders caused by Trinucleotide repeat mutation. Eg Fragile X syndrome
Mitochondrial DNA mutation
Frameshift mutation
Y linked disorder
Trinucleotide repeat mutation
Genetics