True about tachyphylaxis is:
Tachyphylaxis refers to rapid development of tolerance when doses of a drug repeated in quick succession result in marked reduction in response . This is usually seen with indirectly acting drugs , such as ephedrine , Tyramine , nicotine. From medical pharmacology padmaja 4th edition page no 70
Direct sympathomimetics involved
Mechanism clearly understood
Ephedrine tachyphylaxis reversed with dopamine
Indirect sympathomimetics involved
Autonomic nervous system