Mechanism of action of paxclitaxel is
Refer Katzung 10th/893 Refer KDT 6/e p825 Taxanes act by increasing the polymerization of beta tubulin whereas vinca alkaloid cause inhibition of tubulin polymerization. Both of these drugs act by causing the disruption of mitosis and are active in M phase of cell cycle
Topisomaerse inhibition
Increase the polymerization of tubulin
Inhibits protein synthesis
Alkylation of DNA
Chemotherapy