Thiazolidinedione is associated with increasedrisk of?
Ans. is 'a' i.e., Hea failure Thiazolidinediones adverse effects Plasma volume expansion, edema, weight gain, headache, myalgia and mild anemia. Few cases of hepatic dysfunction and some cardiovascular events have been repoed - CHF may be precipitated - they are contraindicated in liver disease and in CHF. Rosiglitazone has been found to increase the risk of fracture, especially in elderly women. Glitazones with insulin can precipitate CHF - avoid such combination. These drugs prevent type 2 DM in prediabetics.
Hea failure
Pulmonary fibrosis
Myocarditis
renal dysfunction