In the fed state, major fate of glucose-6-phosphate in tissues is:
Ans. D. Stored as Glycogen(Ref: Harper 31/e page 136,137)The uptake of glucose into the liver GLUT 2 is independent of insulin.In the well fed state, the concentration of glucose entering the liver increases, so does the rate of synthesis of glucose-6-phosphateThis is in excess of the liver's requirement for energy-yielding metabolism. So it is used mainly for synthesis of glycogen.In both liver and skeletal muscle, insulin acts to stimulate glycogen synthetase and inhibit glycogen phosphorylase.
Storage as fructose
Storage as glyceraldehyde-3-phosphate
Enters HMP shunt via ribulose-5-phosphate
Storage as glycogen
Carbohydrates