Bisphosphonates act by
Bisphosphonates (BPNs) are analogues of pyrophosphate: carbon atom replacing oxygen in the P-0-P skeleton. They inhibit bone resorption by inhibiting osteoclast function- useful to prevent osteoporosis in addition to metabolic bone diseases and hypercalcaemia. (REF.Essentials of Pharmacology TD TRIPATHI 6th EDITION page no 333)
Increasing the osteoid formation
Increasing the mineralization of osteoid
Decreasing the osteoclast mediated resorption of bone
Decreasing the parathyroid hormone secretion
Endocrinology