Increased alkaline phosphatase is seen in ?
Ans. is 'c' i.e., Paget's disease Whenever the activity of osteoblasts increase, serum alkaline phosphatase is raised. Therefore, serum alkaline phosphatase acts as an index of osteoblastic activity. The conditions in which osteoblastic activity is increased and hence the alkaline phosphatase in increased are : - Rickets/osteomalacia Primary hyperparathyroidism Renal osteodystrophy (secondary hyperparathyroidism) Chronic renal failure and secondary hyperparathyroidism Paget's disease (osteitis deformans) Osteoblastic secondaries
Osteoporosis
Multiple myeloma
Paget's disease
Osteolytic metastasis