A feature of Renal vaculitis in children is ?
Answer is A (IgA Raised): The most common systemic vasculitis in children is Henoch Schonlein Purpura, and the most common primary glomerular disease is IgA Nephropathy. H.S purpura and IgA nephropathy may actually represent spectra of same disease and both are associated with elevated levels of IgA which is the single best answer of choice. Antinuclear Antibodies (ANA) and Antineutrophilic Cytoplasmic Antibodies (ANCA) are characteristicaly Negative and serum complement levels are typically normal. Laboratory Feature of Renal vasculitis in children due to HSP Serum IgA levels Elevated (60% of patients have an elevated serum IgA) Antinuclear Antibody (ANA) Negative Antineutrophil cytoplasmic Negative Antibodies (ANCA) Complement (C3, C4) Normal Even though immune complexes containing IgA are essential to the pathophvsiology of HSP, serum complement levels are usually normal Cryoglobulins Negative
IgA raised
Antinuclear antibody in serum
Low complement level
Cytoplasmic antinuclear Ab in serum