What is mechanism of action of curonium drugs as muscle relaxant?
Persistently depolarizing at neuromuscular junction - propey of succinylcholine depolarising eg : succinylcholine 1. MOA - persistent / prolonged depolarising of nicotinic cholinergic receptors 2. fasiculation seen 3. post operative myalgia 4. not reversed by neostigmine 5. train of four response not seen 6. TOF ratio (B/A = 1 ) 7. neuromuscular monitoring not done 8. no post tetanic facilitation non - depolarising 1. MOA - competitive antagonist 2. fasiculation not seen 3. no post operative myalgia 4. reversed by neostigmine 5. train of four response seen 6. TOF ratio (B/A< 1 ) 7. neuromuscular monitoring done 8. post tetanic facilitation seen
Persistently depolarizing at neuromuscular junction
Act competitively on Ach receptors blocking postsynaptically
Repetitive stimulation of Ach receptors on muscle end plate
Inhibiting the calcium channels on presynaptic membrane
NEET 2018