The most common cause of severe hypercalcemia is-
Causes of hypercalcaemia are listed in Box 20.36. Of these, primary hyperparathyroidism and malignant hypercalcaemia are by far the most common. Familial hypocalciuric hypercalcaemia (FHH) is a rare but impoant cause that needs differentiation from primary hyperparathyroidism (HPT). Lithium may cause hyperparathyroidism by reducing the sensitivity of the calcium-sensing receptor. Causes of hypercalcaemia- With normal or elevated PTH levels *Primaryoeiaryhyperparathyroidism *Lithium-inducedhyperparathyroidism *Familialhypocalciuric hypercalcaemia With low PTH levels *Malignancy(lung,breast,myeloma,renal,lymphoma, thyroid) *Elevated1,25(OH)2vitaminD(vitaminDintoxication, sarcoidosis,HIV,othergranulomatousdisease) *Thyrotoxicosis *Paget'sdiseasewithimmobilisation *Milk-alkalisyndrome *Thiazidediuretics *Glucocoicoiddeficiency DAVIDSONS PRINCIPLE AND PRACTICE OF MEDICINE 22ND EDITION PAGENO-767
Vitamin D toxicity
Sarcoidosis
Chronic renal failure
Malignancy
Endocrinology