All of the following are true regarding penicillin G except:-
Probenecid inhibits tubular secretion and increase the duration of action of penicillin G Penicillin G is sho acting. To overcome this problem: Benzathine and procaine group can be added to penicillin G to make it long acting. Benzathine penicillin G is longest acting penicillin. Probenecid can be administered with penicillins. Former inhibits the tubular secretion. Penicillins have wide therapeutic index. A high initial dose can be used.
Probenecid decreases it duration of action
It is active against gram positive organisms
It Splits into 6 amino penicillanic acid by amidase
It acts by inhibiting cell wall synthesis
Cell Wall Synthesis Inhibitors