Orexins are implicated in all except
Orexinergic signaling overexpression alters the sleep-wake cycle and secondarily induces beta-amyloid accumulation and tau-mediated neurodegeneration. Therefore, considering that orexinergic system dysregulation impairs sleep-wake rhythms and may influence AD pathology, it is hypothesized that orexin receptor antagonists are likely potential preventive/therapeutic options in AD patients. Orexin cell-specific lesions do not impair sexual performance and motivation but disrupt conditioned responses associated with sexual reward.
Wakefulness
Sexual behaviour
Appetite
Alzheimer's disease
Renal physiology