All are true about Bater syndrome except?
The defect in Bater syndrome in thick ascending limb of Loop of Henle- | urinary loss of calcium & nephrocalcinosis The salt wasting and polyuria lead to dehydration- stimulates the R.A.A.S- secondary hyperaldosteronism. This explains the hypokalemia. ROMK receptors in TAL are affected leading to urinary loss of potassium. | intra-renal prostaglandins and hence indomethacin is prescribed Secondary aldosteronism explains the development of metabolic alkalosis
Urinary calcium increased
Hypokalemic alkalosis
Mineralocoicoid antagonist can be used.
Normal Blood pressure
Bater syndrome, Gitelman syndrome, Liddle and Comparison with SIADH