All of the following statements about pralidoxime in organophosphate poisoning are true except:-
Organophoshate poisoning - AchE (inhibit Acetyl cholinestrase enzyme) Atropine is drug of choice for organophosphate poisoning Atropine reverses the symptom by blocking receptors Organophosphate poisoning DRUG OF CHOICE- Atropine | | Pralidoxime | | Reactivate Inhibit Receptors Ache enzyme All the oximes are given Intra venously PAM (Pralidoxime ) - periphery (do not cross blood brain barrier) DAM (Diacetyl monoxime) - both in the brain and outside the brain Oximes should be staed as soon as possible after atropine is given If we take long time enzyme aging may occur (enzyme cannot work)
It is given intravenously
It should be staed after 24 hours of poisoning
It does not cross blood brain barrier
Reactivates the AChE enzyme
FMGE 2017