Androgenic activity of the 19 noestosterone nucleus is decreased by ?
Ans. is 'b' i.e., Removal of methyl group at C 19Substitution of a 7a-methyl group in 17b-hydroxyestr-4-en-3-one (19-noestosterone) or its 17a-methyl derivative enhanced the androgenic activities of the parent compounds as well as their ability to bind to b protein and to prostate cell nuclei. Thus, 7a, 17a-dimethyl-19-noestosterone had an apparent affinity for bprotein several times higher than that of 5a-dihydrotestosterone.
Adding alkyl group at C 17
Removal of methyl group at C 19
Adding methyl group at C 18
Substituting chlorine atom at C21