Genetic abnormality in case of late adenoma to carcinoma in Ca colon:
The most frequently mutated tumor suppressor gene in human neoplasia is p53 (TP53), located on chromosomes 17p. Mutations in p53 are present in 75% of colorectal cancers and occurs, rather late in the adenoma-carcinoma sequence. FEARON - VOGELSTEIN ADENOMA CARCINOMA MULTISTEP MODEL
APC
K-ras
DCC
p53
Large intestine