The population frequency for phenylketonuria is 1 in 10,000. What is the carrier frequency for the disease?
a. 1/50(Ref: Nelson's 20/e p 598)It is based on Hardy Weinberg principle: Simplifying it,Carrier frequency for an autosomal recessive disorder = twice the square root of disease incidenceSo 2 X square root of 1/10,000 gives 1/50 as the answer.
Jan-50
1/100
1/500
1/1000
Genetics And Genetic Disorders