All of the following are associated with cardiac looping, EXCEPT ?
Cardiac looping is dependent in pa upon the laterality-inducing genes nodal and left. These genes induce expression of the transcription factor PITX2 in lateral plate mesoderm on the left side and later in mesoderm on the left side the hea. PITX2 may play a role in the deposition and function of extracellular matrix molecules during looping. In addition, NKX2.5 upregulates expression of HAND1 and HAND2, transcription factors that are expressed in the primitive hea tube and that later become restricted to the future left and right ventriclesRef: LANGMAN'S EMBRYOLOGY 11TH ED Chapter 12.
Lefty
PITX2
HAND1
None of the above