Carbimazole as compared to propylthiouracil:
(Ref: KDT 6/e p250) Carbimazole Propylthiouracil Produces an active metabolite, methimazole No active metabolite Less plasma protein binding (PPB) More PPB Crosses placenta Does not cross placenta More potent Less potent Does not inhibit 5'-deiodinase Inhibits 5'-deiodinase
Is less potent
Is shoer acting
Does not produce an active metabolite
Does not inhibit peripheral conversion of T4 to T3
Other topics and Adverse effects