Which of the following prokinetic drugs produces extrapyramidal side effects?
(Ref: KDT 6/e p643, 644) Metoclopramide and domperidone act by blocking D2 receptors. Metoclopramide can cross BBB whereas domperidone cannot. Therefore, metoclopramide can produce extra-pyramidal adverse effects while domperidone is devoid of it. Cisapride acts as 5HT4 agonist. It can cause torsades de pointes.
Metoclopramide
Cisapride
Domperidone
All of the above
Other topics and Adverse effects