Increasing the concentration of norepinephrine in adrenergic synapses leads to
Classification:- Adrenergic receptors are classified into two types a and b. The a receptors were demonstrated to be present prejunctionally as well. To differentiate these release inhibitory prejunctional a receptors, a subdivision into a1 and a2 was suggested. b receptors were fuher subdivided into b1, b2, beta 3subtypes. Alpha2 receptor is located prejunctionally and inhibits the release of neurotransmitter. Ref:- kd tripathi; pg num:-126,127
Activation of tyrosine hydroxylase
Activation of dopa decarboxylase
Increased release of norepinephrine
Activation of presynaptic Gi (C) coupled receptors
Autonomic nervous system