Fluconazole is more effective than itraconazole in the following systemic fungal disease
Ref-KDT 6/e p763,764 Fluconazole has maximum CNS penetration whereas itraconazole has limited entry in the brain. Therefore fluconazole is preferred over itraconazole for the treatment of cryptococcal meningitis. For all other conditions listed in the question, itraconazole is first choice drug.
Pulmonary histoplasmosis
Cryptococcal meningitis
Non-meningeal blastomycosis
Disseminated sporotrichosis
Other topics and Adverse effects