All are examples of competitive enzyme blockage except
Kinetics of enzyme inhibition Competitive inhibitionNon competitive inhibitionKm Increased No change V max No change Decreased Significance Drug action Toxicological (Refer: Harper's Illustrated Biochemistry, 26th edition, pg no: 67-68)
Cyclooxygenase by Aspirin
Thymidylate synthase by 5-FU
Coagulation by Dicumarol
DHFR by Methotrexate
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