Peau d'orange in carcinoma breast is due to:(AIIMS November 2015, DNB 2012, PGI June 95, December 95)
Ans. a. Obstruction of suh-dermal lymphatics (Ref: Bailey 26/e p811, 25/e p840)Peau-d-orange is due to cutaneous lymphatic edema, caused by obstruction of subdermal lymphatics.Peau-d-orangePeau-d-orange is due to cutaneous lymphatic edema, where the infiltrated skin is tethered by sweat ducts, it can not swell, leading to an appearance like orange skinQ.Due to obstruction of subdermal lymphatics (lymphatic permeation by tumor cellsQ)Seen in advanced breast cancerQ (may be seen in chronic abscessQ)
Obstruction of sub-dermal lymphatics
Infiltration of Coopers ligament
Hematogenous dissemination
Nipple involvement
Clinical Presentation and Physiology