Which anaesthetic agent does not affect blood flow to liver?
- Total hepatic blood flow = hepatic aery blood flow + poal blood flow- Liver maintains total hepatic blood flow by autoregulation- All inhalational anesthetic agents disrupt dual blood supply of liver - Halothane completely disrupts dual blood supply- Halothane - acyl halide (metabolite) - Auto immune hepatitis - Enflurane also affects liver blood flow- Isoflurane, sevoflurane & desflurane - maintain hepatic blood flow - Desflurane - Best in maintaining liver blood flow - Not metabolized by liver and kidney - Sevoflurane - Higher MAC- Decreases little amount of hepatic blood flow
Halothane
Isoflurane
Enflurane
Sevoflurane
JIPMER 2018