2, 3 DPG causes ?
Ans. is 'a' i.e., Decrease binding of O2 and hemoglobinDPG is an optional by-product of the glycolytic pathway . DPG binds with deoxygenated hemoglobin but not with oxygenated hemoglobin . Therefore raised DPG concentration releases oxygen from oxyhemoglobin by shifting thefollowing reversible reaction to the right : -HbO, + DPGHb - DPG + 02One molecule of DPG binds with one mole of deoxyhemoglobin.That is why in the presence of raised DPG concentration, less oxygen can combine with hemoglobin at a given PO2. Hence an increase in DPG concentration shifts the oxygen-hemoglobin dissociation curve to the right. Thus 2,3 DPG causes delivery (unloading) of O2 to the tissues.
Decrease binding of O2 and hemoglobin
Increased acidity in RBC
Decreased acidity in RBC
Lysis of RBC