All of the following will cause a shift to the right of the oxygen-hemoglobin dissociation curve, EXCEPT
In oxygen dissociation curve (ODC) of Hb, paial pressure of oxygen is plotted on the X-axis and percentage of hemoglobin saturated with oxygen is plotted on the Y-axis. We get a sigmoidal curve for hemoglobin. Shift of oxygen dissociation curve to right refers to the increased unloading of oxygen. Imagine a person doing exercise in a warm room. Raised CO2, temperature, 2,3-DPG and decreased pH causes shift of ODC to right.
Hypoxia
2,3 DPG
Increase in pH
Increase in temperature
HAEM synth and porphyrias