In Bater syndrome the defect lies in?
Bater Syndrome- defect in thick ascending limb of loop of Henle *Loss of function of (Na+ Cl- K+ co transpoer) *Damage to ROMK & Cl- channel C/F: 1. Hypokalemia, salt wasting 2. Normal BP 3.Met. Alkalosis Dx: 24 hr. urine chloride : elevated *24 hr. urine Ca2+ : elevated DOC: indomethacin
Distal convoluted tubule
Thick ascending limb of loop of Henle
Thin ascending limb of loop of Henle
Proximal convoluted tubule
Bater syndrome, Gitelman syndrome, Liddle and Comparison with SIADH