Which of the following liver disorders is a complication associated with oral contraceptives?
Oral contraceptives produce an intrahepatic cholestasis that is unpredictable (not related to the dose). The incidence of liver cell adenomas is also increased as a result of oral contraceptive use. These vascular tumors have a tendency to rupture during pregnancy, paicularly those in a subcapsular location. A purpoed increase in the incidence of focal nodular hyperplasia (FNH) is associated with oral contraceptive use. Grossly, FNH is characterized by a poorly encapsulated nodule that has a lighter color than the surrounding hepatic parenchyma. On cut section, a centrally located stellate scar radiates out to the periphery of the lesion. Microscopically, the hepatocytes between the scar tissue are normal. A slightly increased risk for hepatocellular carcinoma is another effect of bih control pills on the liver. Oral contraceptives are not associated with drug-induced hepatitis with fatty change, cholangiocarcinoma, cavernous hemangiomas, or fulminant hepatic failure.
Drug-induced hepatitis with fatty change
Cholangiocarcinoma
Cavernous hemangiomas
Intrahepatic cholestasis
Contraception