Choose the TRUE/FALSE statements regarding polycythemia vera: a) The JAK2 gene is located on the sho arm of chromosome 12 b) Splenomegaly will be the initial presenting sign in PV c) Venous and aerial thrombosis may be the presenting manifestation of PV d) Red cell mass and plasma volume determinations are mandatory to establish the presence of an absolute erythrocytosis e) A bone marrow aspirate and biopsy provide specific diagnostic information
The JAK2 gene is located on the sho arm of chromosome 9. A bone marrow aspirate and biopsy provide no specific diagnostic information unless there is a need to exclude some other disorder, these procedures need not be done. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 898, 899
b,c,d-True & a,e-False
a,b,c,e-True & d-False
a,c,d,e-True & b-False
b,c,e-True & a,d-False