Which of the following coagulation factors causes cross-linking and stabilization of clot?
The loose aggregation of platelets in the temporary plug is bound together and conveed into definitive clot bg fibrin. Fibrin is initially a loose mesh of interlacing strands. It is conveed by the formation of covalent cross-linkages to a dense tight aggregate. The latter reaction is catalyzed by activated factor 13 and requires calcium. Ref: Ganong&;s Review of medical physiology, 24th edition.Pg no. 566
Factor XIII
Thrombin
Factor VIII
Factor IX
Cardiovascular system