Drug distribution is inversely propoional to
The extent of distribution of a drug depends on its lipid solubility, ionization at physiological pH, the extent of binding to plasma and tissue proteins, differences in regional blood flow. If PPB is high VD is low, PPB is inversly propoional to vd drugs with low vd usually have high ppb ref; KD Tripathi pharmacology 6th edition (page no;18)
Plasma protein binding
Lipid Solubility
fat layer in the body
structure of drug
General pharmacology