A female neonate with DiGeorge syndrome develops severe muscle cramps and convulsions soon after bih. Which of the following is the cause of convulsions in this neonate?
DiGeorge syndrome: - Caused by failure in development of 3rd and 4th branchial pouches, resulting in Agenesis/ hypoplasia of thymus & parathyroid glands Congenital hea defects Dysmorphic facies -Occurs secondary to deletions on chromosome 22q11.2 - As a result of parathyroid agenesis, patients with DiGeorge syndrome exhibit hypocalcemia, which manifests as increased neuromuscular excitability. - Symptoms range from mild tingling in hands & feet to severe muscle cramps & convulsions.
Acute hemorrhagic adrenalitis
Hypocalcemia
Hypoglycemia
Hypokalemia
Parathyroids