Wire loop thickening of glomerular basement membrane is seen in -
Ans. is 'a' i.e., Systemic lupus erythematosus o Wire loop thickening is a characteristic features of lupus nephritis. o It occurs because extensive subendothelial deposit in kidney causes a peculiar thickening of the capillaries which on light microscopy appear as wire loop lesions. o Wire loop lesions indicate active disease and poor prognosis. o Wire loop lesions are especially common in diffuse proliferative glomerulonephritis, but can also occur in focal proliferative and membranous glomerulonephritis.
Systemic lupus erythematosus (SLE)
Non Insulin Dependent Diabetes Mellitus
Rapidly progressive glomerulonephritis
Malignant hypeension