Which is not a 2nd generation anti–histaminic agent ?
Antihistaminics may be classified into the first generation and the second generation compounds on the basis of CNS penetration and anticholinergic properties. First Generation Anti-histaminics can penetrate the blood-brain barrier and possess additional anticholinergic properties which are lacking in second-generation drugs. Cyclizine is the first generation whereas cetirizine, loratadine and fexofenadine are second generation drugs.
Cetirizine
Cyclizine
Loratadine
Fexofenadine