Which of the following drug combination is supraadditive
Additive: Effect of drug A + B = effect of drug A + effect of drug B Aspirin + paracetamol as analgesic/ antipyretic Nitrous oxide + halothane as general anaesthetic Amlodipine + atenolol as antihypeensive Glibenclamide + metformin as hypoglycaemic Ephedrine + theophylline as bronchodilator Supra additive : Effect of drug A + B > effect of drug A + effect of drug B Acetylcholine + Physostigmine Inhibition of break down Levodopa + carbidopa/ Inhibition of peripheral metabolism benserazide Adrenaline + cocaine/ desipramine Inhibition of neuronal uptake Sulfamethoxazole + trimethoprim Sequential blockade Antihypeensives enalapril+ hydrochlorothiazide: Tackling two contributoryfactors
Nitrous oxide + halothane as general anaesthetic
Glibenclamide + metformin as hypoglycaemic
Sulfamethoxazole + trimethoprim
Ephedrine + theophylline as bronchodilator
Pharmacodynamics