Which of the following combinations can result in severe toxicity due to inhibition of cytochrome 450 enzymes?
Atorvastatin is a statin which is anti dyslipidemic agent and itraconazole is an azole which is anti fungal which are metabolised by Cytochrome 450 oxidase enzyme. Due to inhibition of Cytochrome enzyme toxicity occurs. So third option is a better one.
Amiodarone + phenytoin
Carbamazepine + phenytoin
Atorvastatin + Itraconazole
Phenytoin + Rifampin
JIPMER 2019