70-year-old female came with multiple erosion & flaccid bulla over skin. Slight rubbing of the skin results in exfoliation of the outermost layer, forming a blister within minutes. Erosions were present over oral mucosa. No target lesion seen. Diagnosis?
Ans. a. Pemphigus vulgarisMucosal involvement, nikolsky sign (exfoliation of skin on rubbing) positive, flaccid bulla with erosions - all are features of pemphigus vulgaris.Target lesions are seen in erythema multiformeMucosal involvement is absent in bullous pemphogoid.
Pemphigus vulgaris
Bullous pemphigoid
Dermatitis herpetiformis
SJS
Vesiculobullous (Blistering) Disorders