C3-nephritic factor (C3Ne) is associated with membranoproliferative glomerulonephritis. Which of the following statements regarding C3Ne is most appropriate?
Activation of the alternate pathway of complement system is seen in type-II membranoproliferative glomerulonephritis. C3 Nephritic factor is an autoantibody of IgG class which is produced against alternate C3 convease. C3Ne, like properdin, stabilizes the C3b which is normally degraded by regulatory complement proteins like H and I. Activation of alternate pathway of complement system immune complex deposition in the glomeruli results in membranoproliferative glomerulonephritis Ref: Fervenza F.C., Cattran D.C. (2009). Chapter 26. Membranous Nephropathy. In E.V. Lerma, J.S. Berns, A.R. Nissenson (Eds), CURRENT Diagnosis & Treatment: Nephrology & Hypeension.
It is a native glomerular antigen
It is a circulating immune complex
It is an IgG
Complement C3 convease