True regarding gestational trophoblastic neoplasia are all except: March 2008
Ans. A: 13HCG is highly elevated in both the forms of molar pregnancy Molar pregnancy is characterized by the presence of a hydatidiform mole (or hydatid mole, mola hydatidosa. Molar pregnancies are categorized into paial and complete moles. Complete moles have no identifiable embryonic or fetal tissues and arise when an empty egg with no nucleus is feilized by one (or occasionally two) normal sperm; the genotype is typically 46,XX but can also be 46,XY or 23,X. In contrast, a paial mole occurs when a normal egg is feilized by two (or occasionally three) spermatozoa, and the genotypes can be 69, XXY or 92, XXXY. Difference between complete mole and paial mole: Fetus is absent in complete mole while present in paial mole Trophoblast hyperplasia is diffuse in complete moles while focal in paial mole Uterine size is more than date in complete mole while less than date in paial mole Beta hCG is high in complete mole while only slightly elevated in paial mole Classical symptoms are common in complete mole only.
13HCG is highly elevated in both the forms of molar pregnancy
Classical symptoms are only seen with complete moles
The genotype is 46XX in majority of complete moles
The genotypes is 69XXY in majority of incomplete moles