True regarding clavulanic acid is ?
Ans. is 'a' i.e., Deactivates Beta lactamase Clavulanic acid Clavulanic acid is a beta-lactamase inhibitor. Addition of clavulanic acid re-estabilishes the activity of amoxicillin against (3-lactamase producing organisms. Clavulanic acid has a b-lactam ring but no antibacterial activity of its own. Clavulanic acid is a suicide inhibitor, it gets inactivated ofter binding to the enzyme because of ireversible binding. Clavulanic acid is a progressive inhibitor, binding is reversible initially, but become irreversible later due to covalent bonding, i.e. inhibition increases with time. Other beta-lactamase inhibitors Sulbactam is combined with ampicillin. Tazobactom is combined with piperacillin.
Deactivates beta lactamase
Decreases renal excretion of amoxycillin
Potentiates action of penicillin
Decreases the side effects of amoxicillin