Which of the following statement is true about nitrates
Nitrates acts by releasing nitric oxide which increases cGMP that cause dephosphorylation of myosin light chain kinase. These are preferential dilators of venules because glutathione reductase (enzyme that release NO from nitrates) is principally present at these sites. These agents are smooth muscle relaxants and can be used in colic and achlasia cardia Refer kDT 6/e p523
Acts by raising CGMP which causes dephosphorylation of MLCK
Metabolized by glutathione reductase
Used in achlasia cardia
All of the above
Cardiovascular system