Prozone phenomenon is due to:
Ans: B (Antibody excess) Ref: Ananthonaravan. Panikar CJ Textbook of .Microbiology. 8th Edition. John Wiley & Sons: 2009. Pg. 104Explanation:Antigen and antibody can combine in various proportions.State of antibody excess - ProzoneOptimal ratio - Zone of equivalenceState of antigen excess - Postzone (See the following figure)The prozone is very important in serodiagnosisSera rich in antibody may sometimes give a false negative precipitation or agglutination resultE.g. Patients with Brucellosis are known to exhibit prozone phenomenonThe serum should be diluted several times when prozone phenomenon is suspected
Antigen excess
Antibody excess
Excessive immune complex
Acute phase reactants
Immunology