Low Vd means
The volume of distribution (V) relates the amount of drug in the body to the concentration of drug (C) in blood or plasmaVd = amount of drug in body/concentration of drug (C)Drugs with low volumes of distribution have much lower concentrations in extravascular tissue than in the vascular compament.Katzung Pharmacology 12th edition Pg: 38
The drug has low half life
The drug does not accumulate in tissues
The drug has low bioavailability
The drug has weak plasma protein binding
General pharmacology