Dicumarol is a drug that impairs the utilization of vitamin K by the liver. Dicumarol therapy, therefore, would decrease the plasma concentration of which of the following procoagulants?
Dicumarol inhibits the action of vitamin K, which is a necessary cofactor for the enzyme that catalyzes the conversion of glutamic acid residues to g-carboxyglutamic acid residues.Six of the proteins involved in clotting require conversion of a number of glutamic acid residues to g-carboxyglutamic acid residues before being released into the circulation, and hence all six are vitamin K-dependent. These proteins include factors II (prothrombin)Others are; factors VII, IX, and X, protein C, and protein S Ref: Ganong's Review of Medical Physiology Twenty-Third Edition Page No: 535
Prothrombin
Fibrinogen
Factor XI
Ac-globulin (factor V)
Cardiovascular system