Which is not true about PBC?
.PBC(primary biliary cirrhosis) is a chronic & slowly progressive cholestatic disease of autoimmune etiology characterised by injury of the intrahepatic bile ducts that may eventually lead to liver failure.The risk for HCC is increased in PBC.So screening for it can be done by ultrasound scan every 6 months. Most of the patients with PBC(>90%) have antimitochondrial Ig M antibodies against pyruvate dehydrogenase complex(PDC-E2).
No increase in risk of hepatocellular carcinoma
Often asymptomatic
Elevated 1gM
Positive antimitochondrial antibody
G.I.T