Which of the following is not true of acute PSGN (Post Streptococcal glomerulonephritis)?
In PSGN, ASO titer is increased in more than 80% patients following streptococcal sore throat; anti-DNase B is elevated in cases of streptococcal skin infection. The level of serum C3 is low in 90% patients but normalizes by 6 - 8 weeks. Persistent low C3 levels indicate other forms of GN and requires renal biopsy On electron microscopy, electron-dense deposits, or "humps," are observed on the epithelial side of the glomerular basement membrane
Electron dense humps on GBM
PSGN following streptococcal skin infection will usually show ASLO titre positive
Renal biopsy is indicated if prolonged hypocomplementemia persists beyond 2 months
C3 is low in acute phase returns to normal in 6 - 8 weeks
Nephritic & Nephrotic Syndrome