Bile acids are synthesized from ?
Primary bile acids are cholic acid and chenodeoxycholic acid, which are synthesized from cholesterol in liver. In the intestine some of the primary bile acids are conveed into secondary bile acids, i.e., deoxycholic acid (formed from cholic acid) and lithocholic acid (derived from chenodexoxycholic acid). Glycine and taurine conjugates of these bile acids are called as bile salts. For example, cholic acid is a bile acid, and its glycine conjugate (glycocholic acid) is a bile salt. Bile salts help in digestion and absorption of fat by emulsification and micelles formation. Bile salts act as detergents, i.e., they have surface tension lowering action. Detergent action is due to amphipathic nature of bile salts (Note : Amphipathic molecules are molecules that contain both hydrophobic non-polar as well as hydrophilic-polar ends). Ref: Guyton 12th Ed.
Heme
Cholesterol
Ribulose
Arachidonic acid
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