Pro-apoptotic gene and anti-apoptotic gene belong to which gene family?
* The major mechanism of intrinsic mitochondrial pathway of apoptosis is by pro- and anti-apoptotic members of bcl proteins.* Bcl protein was first detected on B cell lymphoma and hence its name.* It is located on mitochondrial inner membrane and regulates cell growth and cell death.* Pro-apoptotic mechanisms can damage mitochondrial membranes and allow leakage of cytochrome C into the cytoplasm. Cytochrome C is the lifeline of intact mitochondria.Growth promoter/anti-apoptotic proteinsPro-apoptotic proteinsBcl-2, Bcl-X and Mcl-1Bim, Bad and Bid
p53
Bcl
BRAF
Rb
Cellular Pathology