The rate-limiting step for norepinephrine synthesis
In the synthesis of Norepinephrine, Tyrosine is hydroxylated to 3,4dihydroxyphenylalanine by tyrosine hydroxylase. This enzyme catalyses the rate limiting reaction and require tetrahydrobiopterin as coenzyme.Ref: Biochemistry, U. Satyanarayana, Fouh edition, page no: 349
Conversion of phenylalanine to Tyrosine
Conversion of Tyrosine to DOPA
Conversion of DOPA to dopamine
Conversion of dopamine to norepinephrine
Metabolism of protein and amino acid