CD59 deficiency leads to:
Ref. Robbins Pathology. 9th edition. Page. 642
PNH :

Defect in GPI linked proteins  - CD55 and CD 59
Mutation in PIGA gene
Intravascular hemolysis
Triad – IV hemolysis, Thrombosis, Pancytopenia
Can result in AML
Diagnostic methods


HAM test – no more used
Gel card test
Flow cytometry – IOC
Best – FLAER (Fluorescent Aerolysin test)
PNH
Chediak-Higashi disease
Hairy cell leukemia
Hemolytic uremic syndrome