Resistance to Zidovudine develops due to
Zidovudine is a nucleoside reverse transcriptase inhibitors which is a viral enzyme .HIV undergoes mutations in this enzyme to become resistant to NIs Refer :KDT 6/e p770
Mutation at reverse transcriptase
Increased efflux of the drug from inside the cell
Increased metabolism of drug
Decreased Zidovudine 5 triphosphate formation
General anatomy