Tear drop cell together with leukoerythroblast seen in ?
Ans. is 'd' i.e., Primary myelofibrosisPrimary Myelofibrosis :?The hallmark of primary myelofibrosis is the development of obliterative marrow fibrosis. The chief pathologic feature is the extensive deposition of collagen in the marrow by non-neoplastic fibroblasts. It is probably caused by the inappropriate release of fibrogenic factors; platelet-derived growth factor and TGF-fl from neoplastic megakaryocytes.Marrow distoion leads to the premature release of nucleated erythroid and early granulocyte progenitors (leukoerythroblastosis) in peripheral blood.Teardrop-shaped red cells (dacryocytes), cells that were probably damaged during the bihing process in the fibrotic marrow, are also often seen in peripheral blood.
Megaloblastic anemia
Iron deficiency anemia
Aplastic anemia
Primary myelofibrosis