Resistance to acyclovir is most commonly due to mutation in the viral gene that encodes a protein that
Ref-KDT 6/e p768 Nucleoside/tide analogues act by conveing to NTPs. First phosphorylation step occurs inside the virus and resistance occurs if there is mutation in this gene
Conves viral RNA into DNA
Phosphorylates acyclovir
Transpos acyclovir into the cell
Transpos acyclovir out of the cell
Other topics and Adverse effects