Mechanism of action of tetanospasmin is
Tetanus toxin acts presynaptically. It specifically blocks synaptic inhibition in the spinal cord, presumably at inhibitory terminals that use glycine and GABA as neurotransmitters. The abolition of spinal inhibition causes the uncontrollrd spread of impulses initiated anywhere in the central nervous system. This results in muscle rigidity and spasms. Reference: Textbook of Microbiology; Anathanarayan and paniker's; 10th edition; Page no: 265
Inhibition of GABA release
Inhibition cAMP
Inactivation of Ach receptors
Activation of cAMP
Bacteriology