Which of the following statement about Phenytoin is true?
Phenytoin follows zero order kinetics at therapeutic plasma concentration. Other drugs following zero order kinetics are warfarin, alcohol, aspirin, theophylline, and tolbutamide. *Phenytoin is a powerful microsomal enzyme inducer. *Phenytoin is metabolized to inactive products by liver. *Use of Phenytoin during pregnancy can cause Fetal hydantoin syndrome characterized by hypoplastic phalanges, cleft lip, cleft palate and microcephaly. It occurs due to a metabolite of phenytoin, arene oxide. REF: KATZUNG 14TH ED.
It follows zero order kinetics
It is not teratogenic
It is excreted unchanged in urine
It does not induce microsomal enzymes
Central Nervous system