The H3 receptor agonist exhibits all of the following actions except:
Ans. (B) Increase in H1 mediated gastrin secretion(Ref: KDT 6th/e p153)H3 receptors act as pre-synaptic receptors and decrease the release of histamine and other neurotransmitters. These antagonize H1 mediated wakefulness and bronchoconstriction. These also decrease gastrin release and produce negative chronotropic effect. Inverse agonist of H3 receptor (tiprolisant) is approved for Narcolepsy.
Inhibition of H1 receptor induced wakefulness
Increase in H1 mediated gastrin secretion
Inhibition of H1 mediated bronchoconstriction
Negative chronotropic effect on atria
Anti Histaminics