Which of the following statement is true regarding Fixed Dose Combination of drugs
Fixed Drug Combination (FDC) Two different drug moieties are combined into a single pharmaceutical formulation. * As a rule, two drugs are ideal for combination into a FDC only when they have comparable pharmacokinetics. E.g: Cotrimoxazole = Sulfamethoxazole (t1/2 -11h) + Trimethoprim(t1/2 - 10h) Syndopa = Levodopa (t1/2 -1.7h) + Carbidopa (t1/2 -2h) Ref:- HL & KK Sharma's Principles of Pharmacology 3rd Ed; Pg.No: 57-8
Adverse effect of one drug may be reduced by the other drug
Two drugs with different pharmacokinetics can be combined easily
Dose of one drug can be altered independently as per requirement
Adverse effect can be ascribed to a single drug
General pharmacology