Neuroblastomas: Good prognostic factor is
Prognostic Factors in Neuroblastomas: Variable Favourable Unourable Stage Stage 1, 2A, 2B, 4S Stage 3,4 Age <18 months >18 months Evidence of Schwannian stroma and ganglionic differentiation Present Absent Mitosis-Karyorrhexis index <200/5000 cells >200/5000 cells DNA-ploidy Hyperdiploidy or near-triploid Near-diploid N-MYC Not amplified Amplified Chromosome 17q gain Absent Present Chromosome 1p loss Absent Present Chromosome 11q loss Absent Present TRKA expression Present Absent TRKB expression Absent Present Telomerase expression Low or absent Highly expressed Ref: Sabiston 20th edition Pgno: 1887
N-myc amplification
RAS oncogene
Hyperdiploidy
Translocations
Endocrinology and breast