In genetic deficiency of MPO the increased susceptibility to infections is due to
Ref Robbins 8/e p53 ,56,9/e p76 Myeloperoxidase (MPO) is a hemoprotein expressed in azurophilic granules of neutrophils and in the lysosomes of monocytes. The enzyme has strong antibacterial propeies and is unique in its ability to generate potent bactericidal compounds such as hypochlorous acid (HOCl) from hydrogen peroxide and the halide, chloride
Defective production of prostaglandin
Defective rolling of neutrophil
Inability to produce hydroxyl halide radicals
Inability to produce hydrogen peroxide
General anatomy