Cause of vasodilatation in spider nevi
Spider angiomas form due to failure of the sphincteric muscle surrounding a cutaneous aeriole. The central red dot is the dilated aeriole and the red "spider legs" are small capillaries carrying away the freely flowing blood. If momentary pressure is applied, it is possible to see the emptied capillaries refilling from the center. No other angiomas show this phenomenon. The dilation, in turn, is caused by increased estrogen levels in the blood. Many pregnant women and women using hormonal contraception have spider angiomas, which is due to high estrogen levels in their blood. Individuals with significant liver disease also show many spider angiomas, as their liver cannot metabolize circulating estrogens, specifically estrone, which derives from the androgen androstenedione Ref - Wikipedia https://en.m.wikipedia.org/wiki/Spider_angioma
Hepatotoxins
FSH
Estrogen
Testosterone
G.I.T