Fibrinogen degradation products help in detection of:
Disseminated intravascular coagulation- Multiple coagulation factors are consumed and are therefore deficient. Plasminogen bound to platelet-fibrin thrombi is conveed to plasmin by plasminogen activators. Plasmin cleaves fibrinogen as well as fibrin to generate fibrin degradation products (FDPs). TTP and HUS Activation of the coagulation cascade is not of primary impoance, Hence laboratory tests of coagulation, such as the PT and PTT, are usually normal.
Haemophilia
DIC
TTP
Thrombosthenia
Hematology