Antihypertensive safe in renal disease is?
ANSWER: (B) AmlodipineREF: KDT 6 th edition page 543, 544See APPENDDC- 88 ANTI HYPERTENSIVE MEDICATIONS"Calcium channel blockers are drug of choice for in cyclosporine induced hypertension in renal transplant recipients""The dihydropyridines (DHPs) are the most potent Ca2+ channel blockers. DHPs reduces albuminuria and slows progression in Diabetic nephropathy"Calcium channel blockersPhenyl alkylamine: verapamilBenzothiazepin: DiltiazemDHP; Dihydropyridines: Nifedipine, Felodipine Amlodipine, Nitrendipine, Nimodipine, Lacidipine, Lercanidipine, BenidipineMonotherapy with CCBs is effective in - 50% hypertensives; their action is independent of patient's renin status, and they may improve arterial compliance. Other advantages of CCBs are:Do not compromise haemodynamics: no impairment of physical work capacity.No sedation or other CNS effects; cerebral perfusion is maintained.Not contraindicated in asthma/ angina (especially variant) and PVD patients: may benefit these conditions.Do not impair renal perfusion.Do not affect male sexual function.No deleterious effect on plasma lipid profile, uric acid level and electrolyte balanceShown to have no/minimal effect on quality of life.No adverse foetal effects; can be used during pregnancy (but can weaken uterine contractions during labour).
Atenolol
Amlodipine
Thiazide
Methyl dopa
Anti-Hypertensive