Which of the following are intracellular events occurring in fibroblast during synthesis of collagen-
Formation of triple helix (of pre-a-chains) takes place intracellularly in RER.
Formation of a cross-link between fibrils (i.e. self-assembly of tropocollagen monomers into mature collagen fiber) occurs extracellularly after secretion from fibroblasts.
Glycosylation also occurs intracellularly, but its glycosylation of hydroxylysine (not of proline).
Hydrolysis of procollagen to collagen
Glycosylation of proline
Formation of triple helix
Formation of covalent cross link b/w fibrils