All of the following statements about immunosuppressants are true EXCEPT :
Mycophenolate mofetil acts by blocking IMP dehydrogenase.
Cyclosporine and tacrolimus are calcineurin inhibitors that act by decreasing the transcription of IL-2 gene. Cyclo­sporine is commonly used to prevent rejection in transplant recipients.
Sirolimus acts by inhibiting mTOR (a tyrosine kinase) that is the target of IL-2.
Sirolimus acts by inhibiting the action of IL–2
Tacrolimus inhibits calcineurin pathway
Mycophenolate acts by inhibiting GMP dehydrogenase
Cyclosporine is an integeral component of transplant rejection regimen