This type of lesion is seen in which condition?
Ans. B. Pseudohypoparathyroidisma. The hands in pseudohypoparathyroidism. Note the characteristic shortening of the fourth and fifth metacarpals.b. Pseudohypoparathyroidism is a condition associated primarily with resistance to the parathyroid hormone.c. Patients have a low serum calcium and high phosphate, but the parathyroid hormone level (PTH) is actually appropriately high (due to the hypocalcemia).d. Its pathogenesis has been linked to dysfunctional G Proteins (in particular, Gs alpha subunit).Presentation and differentiala. Patients may present with features of hypocalcaemia including carpopedal muscular spasms, cramping, tetany, and if the calcium deficit is severe, generalized seizures.b. IQ is typically mildly depressed or unaffected. Additional characteristics include short stature, obesity, developmental delay, and calcification of the basal ganglia in the deep white matter of the brain.c. Type 1a Pseudohypoparathyroidism is clinically manifest by bone resorption with blunting of the fourth and fifth knuckles of the hand, most notable when the dorsum of the hand is viewed in closed fist position.d. This presentation is known as 'knuckle knuckle dimple dimple' sign (Archibald's Sign).e. This is as opposed to Turner syndrome which is characterized by blunting of only the fourth knuckle, and Down's syndrome, which is associated with a hypoplastic middle phalanx.
Rheumatoid arthritis
Pseudohypoparathyroidism
Osteoarthrosis
Psoriasis
Skin