Genotype in Kleinfelters syndrome is -
Ans. is 'a' i.e., 47XXY Klinefelter Syndromeo Klinefelter syndrome is seen in 1:500 males.o The patient with this rare disorder externally resembles a male in general body conformity, the penis is small or normal in size, the testes are small, but as a rule are normally placed,o Sterility is common, gynaecomastia is frequently present, the voice may be high pitched, and the appearance may be eunuchoid.o The patient is often mentally defective or delinquent.o Most of these individuals are sex chromatin positive like females because of the extra X chromosomeo Genetic analysis reveals their karyotype(genotype) to be 47 XXY.o Testicular biopsy usually reveals hyaline degeneration of the seminiferous tubules and overgrowth of Leydig cells as a result of which sterility is so often the presenting symptom,o Sole-to-pubic length is more than normal.o The person should be bred as male and should not be told about chromosomal abnormality. Testosterone may help. The breasts may need surgical excision.
47XXY
46XY
46XX
47XXO
Classification of DSD