All of the following statements regarding volume of distribution are true except:
Vd = Amount of drug given / Plasma concentration . So, option 'B' is wrong.t1/2 = (0.693 * Vd ) / Clearance * So, Half life is directly propoional to volume of distribution. * Skeletal muscle relaxants have low Vd so that they can't go to brain etc. * High plasma protein bound drugs are less distributed so less volume of distribution.
Half life is usually propoional to Vd
Calculated by t1/2 multiplied by log2
Skeletal muscle relaxants have low Vd
High plasma protein bound drugs have low Vd
Pharmacodynamics