The amino acid derived neurotransmitter used for treating depression is
Serotoninergic neurons project from the brainstem( dorsal raphe nuclei* to the cerebral coex, hypothalamus, thalamus, basal ganglia, septum, and hippocampus. serotonin is an impoant regulator* of sleep, appetite, body temperature, metabolism, and libido. Serotoninergic neurons projecting to the suprachiasmatic nucleus (SCN) of the hypothalamus help regulate circadian rhythms. The serotonin "tone" shows a seasonal fluctuation and temporal response to stress. chronic stress causes decreased 5-HT activity and depletion of 5-HT stores. 5-HT dysfunction has been documented by low CSF levels of 5-HIAA, decreased regional cerebral metabolism. HISTAMINE is a neurotarnsmitter that controls wakefulness, that is the reason for some of the psychotropic medications having anti hystmainergic side effect causes sedation ACETYLCHOLINE is a nurotransmitter that is in charge of parasympathetic nervous system. in psychiatry the main disorder that is is involved with acetylcholine is sleep disorders and dementia. acetylcholine is called as REM ON neuro transmitter, that is it controls RAPID EYE MOVEMNT SLEEP in dementia there is degradation of acetylcholine , thus we use CHOLINE ESTERASE INHIBITORS in the treatment of dementia Reference: P.1669 1670 chap 13.4 Mood Disorders: Neurobiology (Kaplan & Sadock's Comprehensive Textbook of Psychiatry, 9th Edition)
Seratonin
Histamine
Ach
None
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