Ram Prasad is admitted to Guru Teg Bahadur Hospital with respiratory infection for which antibiotic tobramycin is ordered. The clearance and vd of tobramycin in him are 160ml/min and 40L ,respectively.if you wish to give Ram Prasad and intravenous loading dose to achieve the therapeutic plasma concentration of 4mg/L rapidly, how much should be given
Ref-Katzung 10/e p45 Loading dise= Vd xtarget Plasma concentration =40Lx4mg/L =160mg clearance plays no role in the determination of loading dose. it is given to confuse you
0.1mg
10mg
115.2mg
160mg
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