Which of the following aminoglycosides has highest nephrotoxicity?
Small amounts that are absorbed from the gut or topical sites are excreted unchanged by kidney. This may accumulate in patients with renal insufficiency-cause fuher kidney damage and ototoxicity. Neomycin is contraindicated if renal function is impaired. ESSENTIALS OF MEDICAL PHARMACOLOGY page 750
Paramomycin
Streptomycin
Amikacin
Neomycin
Chemotherapy