Ivermectin act by ?
Ivermectin : MOA :induce paralysis by activating Glutamate-gated Cl- channels foundonly in Inveebrates(Nematode nerve or muscle cells) and causes hyperpolarizationby increasing intracellular Chloride concentration, resulting in paralysis.It also binds with high affinity to GABA-gated and other ligand-gated Cl- channels in nematodes such as Ascaris . USES: It is drug of choice for Strongyloidiasis and Onchocerciasis. It is also useful for Ascariasis, Enterobiasis, Cutaneous Larva Migrans and Uncomplicated Scabies.
Inhibition of pyruvate ferridoxin oxidoreductase
Inhibition of Nicotinic Acetycholine receptor
Activation of Glutamate gated Chloride channels
Inhibition of heme polymerase
Anti-Parasitic Drugs