Dose reduction should be done for which of the following anticancer drug, if Allopurinol is used
Allopurinol inhibits the metabolism of 6-mercaptopurine and result in toxicity. Therefore if Allopurinol is used, dose of 6-mercaptopurine should be decreased by 75%.
Methotrexate
Mitoxantrone
6-Mercaptopurine
Mitomycin-C