Anti-inflammatory action of steroids due to
PLA2 has been shown to promote inflammation in mammals by catalyzing the first step of the arachidonic acid pathway by breaking down phospholipids, resulting in the formation of fatty acids including arachidonic acid. This arachidonic acid is then metabolized to form several inflammatory and thrombogenic molecules. Excess levels ofsPLA2 is thought to contribute to several inflammatory diseases.Ref: Ganong&;s review of medical physiology; 24th edition
Inhibiton of phospholipase A2
Inhibhition of cyclooxegenase
Increased activity of lipolipase
Inhibition of lipo oxegenase
Endocrinology