Isotretinoin is:
Isotretinoin is a synthetic retinoid i.e. 13 cis retinoic acid uses:- Acne vulgaris Oral leukoplakia Pityriasis rubra pilaris Side effects:- Alopecia Tendon rupture/tendinitis Elevation of Lipoprotein (a) Teratogenicity. All-trans retinoic acid is involved in cell differentiation. All-trans retinoic acid binds to nuclear receptors (retinoic acid receptors). The activated retinoic acid-receptor complex interacts with response elements on the DNA and regulates the transcription of specific genes in different tissues. Ex: Control of expression of keratin gene in epithelial tissues. NOTE: All-trans retinoic acid (ATRA) is used in the treatment of acute promyelocytic leukemia.
All trans retinoic acid
All cis retinoic acid
13 trans retinoic acid
13 cis retinoic acid
Vitamins and Minerals