Most common extra articular manifestation of Ankylosing spondylitis is
(A) Anterior uveitis # Most common extra articular manifestation is ACUTE ANTERIOR UVEITIS, which occurs in 40% of patients and can antedate the spondylitis. Attacks are typically unilateral, causing pain, photophobia, & increased lacrimation. These tend to recur, often in opposite eye. Up to 60% of patients have inflammation in the colon or ileum. This is usually asymptomatic, but in 5 to 10% of patients with AS, frank IBD will develop. Aortic insufficiency, sometimes producing symptoms of congestive heart failure, occurs in a few percent of patients, occasionally early in the course of the spinal disease but usually after prolonged disease. Third-degree heart block may occur alone or together with aortic insufficiency. Gall stones are not a prominent feature. Mortality attributable to AS is largely the result of spinal trauma, aortic insufficiency, respiratory failure, amyloid nephropathy, or complications of therapy such as upper gastrointestinal hemorrhage.
Anterior uveitis
Inflammatory bowel disease
Gallstones
Heart block
Miscellaneous