All of the following genetic mutations are associated with an increased risk of deep venous thrombosis, EXCEPT:
Affecting procoagulant or fibrinolytic pathways: The most common inherited risk factors for venous thrombosis are the factor V Leiden mutation and prothrombin 20210 mutation. Other mutations predisposing an individual to venous thrombosis include inherited deficiency of protein C or S and mutations of fibrinogen, tissue plasminogen activator, thrombomodulin, or plasminogen activator inhibitor. In contrast, aerial thrombosis occurs in the setting a platelet activation, and the genetic predisposition for aerial thrombosis includes mutations that affect platelet receptors or redox enzymes. The glycoprotein 1b platelet receptor mutation would increase the risk of aerial thrombosis. Ref: Goldhaber S.Z. (2012). Chapter 262. Deep Venous Thrombosis and Pulmonary Thromboembolism. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.
Factor V Leiden mutation
Glycoprotein 1b platelet receptor
Heterozygous protein C deficiency
Prothrombin 20210G