Dose of drug require no or minor adjustment in renal failure, except -
Ans. is 'b' i.e., Vancomycin o Vancomycin causes renal toxicity which is dose related therefore significant dose reduction is needed in renal failure. o Rest of the drugs asked in the question are metabolised mainly in liver therefore no adjustment needed in renal failure.
Doxycycline
Vancomycin
Chloramphenicol
Clindamycin