True regarding IgA nephropathy is
IgA nephropathy, characterized by mesangial deposits of IgA-containing immune complexes, is the most common cause of the nephritic syndrome worldwide; it is also a common cause of recurrent hematuria; it commonly affects children and young adults and has a variable course. Ref: Robbins basic book of pathology 9th edition page 531 The clinical picture is usually characterized by recurrent bouts of haematuria that are often precipitated by mucosal infections. Mild proteinuria is usually present and occasionally nephrotic syndrome may develop. Ref: HARSH MOHAN TEXTBOOK OF PATHOLOGY 6th ed. pg no: 674 Histologically, the lesions in IgA nephropathy vary considerably.The glomeruli may be normal or may show mesangial widening and segmental inflammation confined to some glomeruli (focal proliferative GN); diffuse mesangial proliferation (mesangioproliferative GN); or (rarely) ove crescentic GN. The characteristic immunofluorescence picture is of mesangial deposition of IgA, often with C3 and properdin and smaller amounts of IgG or IgM. Ref: Robbins basic pathology 9th edition page 530
Usually seen in children <10 years of age
Microscopic hematuria is common presentation
Recurrent gross hematuria following respiratory infections
Decreased serum IgA
Urinary tract