A study under Australian collaborative trial on steroids use in neonates was done. Which of the following is true -
Ans is 'b' i.e., Coicosteroid to children causes behavioural worsening o The Australian Collaborative Trial of Repeat Dose of Steroids (ACTORDS) conducted as multicentric RCT, in Australia and New Zealand by Crowtheriv, v and colleagues enrolled 982 pregnant women less than 32 weeks to receive either single dose of intramuscular Betamethasone or salined placebo weekly till 32 weeks of gestation or delivery which ever was earlier. This study showed some sho term benefits in the repeat coicosteroid group with significant reduction in RDS (33% vs. 41%, RR = 0. 82. There was also shoer duration of mechanical ventilation, lesser need for oxygen therapy and less severe lung disease. The mean weight, length and head circumference were not different. However the weight and head circumference Z scores were lower in the repeat steroid dose group. In the long term follow up these infants at 18-22 months corrected age there was no difference in growth, major disability or lung disease between the two groups. There was increased occurrence of attention problems in repeat steroid group.
No difference between placebo & coicosteroid
Coicosteroid to children causes behavioural worsening
Coicosteroid to children causes reduction in head circumference
Coicosteroid to children causes neuro sensitivity degradation