Drug induced portal hypertension is seen with -
Normal doses of vitamin A are not associated with liver injury or liver test abnormalities, but higher doses can be toxic
Mechanism of Injury
• Excess vitamin A is stored in stellate cells in the liver and accumulation can lead to their activation and hypertrophy, excess collagen production, fibrosis and liver injury.
• Serum bilirubin is typically only mildly elevated.
• Liver biopsy is diagnostic
Vitamin A toxicity
Methotrexate
Aldomet
Valproic acid