Local Anesthetic first used clinically aEUR'
Cocaine [Ref- Miller Anaesthesia, Lee Synopsis of Anaesthesia I2th/e p. 591-5921 The origin of modern local anaesthesia is credited to Carl poller, an ophthalanzologist who demonstrated the use of topical cocaine for surgical anaesthesia of the eye. - Cocaine had been isolated from the coca plant in 1855 by Gaedicke and later purified in 1860 by Albe neimann. - In 1884 the Surgeon William Halsted demonstrated the use of cocaine for intradermal infiltration and nerve blocks (including the .facial nerve, the brachial plexus, the pudendal nerve and posterior tibial nerve).
Procaine
Lignocaine
Bupivacaine
Cocaine