All are true about immunosuppressants except?
Ans. is 'c' i.e., Mycophenolate inhibits purine synthesis GMP dehydrogenase o Mycophenolate inhibits purine synthesis inosine monophosphate (IMP) dehydrogenase (not GMP dehydrogenase). About other options o Tacrolimus enters target cells and binds to FKBP. The complex then inhibits calcineurin response of the helper T cell to antigenic stimulation fails. o Glucocoicoids bind cytosolic receptors and heat shock proteins, block transcription of IL-1, 2, 3, 6, IFN-y and TNF-cs o Sirolimus complexes with FkBP -12 and then blocks p7deg S6 kinase in the IL-2 receptors pathway for proliferation.
Tacrolimus inhibits calcineurin pathway
Steroids binds to cytosolic receptors and heat shock proteins
Mycophenolate inhibits purine synthesis GMP dehydrogenase
Sirolimus will block kinase in the IL-2 receptor pathway