The endothelins are secreted mainly by endothelial cells. All of the following are true, EXCEPT:
Endothelin-1 (ET-1), the most powerful vasoconstrictor produced in humans. ET-1 decreases GFR and renal plasma flow through stimulation of vascular smooth muscle and mesangial cell contraction. ET-1 can also act on the hea to cause hyperophy, on the adrenal gland to release aldosterone, and on the kidney to promote sodium and water retention. Ref: Hall J.E., Granger J.P., Jones D.W., Hall M.E. (2011). Chapter 69. Pathophysiology of Hypeension. In V. Fuster, R.A. Walsh, R.A. Harrington (Eds), Hurst's The Hea, 13e.
Enhances renal pressure natriuresis
Vasoconstriction
Decreased GFR
Act on the hea to cause hyperophy