Which of these is characteristic of amyloidosis?
Ans. is 'c' i.e., Beta Pleated, congophilic, fibrillary Amyloidosis o Amyloidosis refers to a variety of condition in which amyloid proteins are abnormally deposited extracellularly between the cells in various organs / tissues. What is Amyloid ? o Amyloid is a protein that has an alteration in its secondary structure which impas it a paicular insoluble form, called the beta pleated sheet conformation. Chemical nature of amyloid material o Amyloid material is composed of two components ? 1) Major component (95%) --> Fibril amyloid protein. 2) Minor components (5%) P-component, proteoglycans and sulfated glycosaminoglycans. o Fibril amyloid protein is responsible for tissue dysfunction due to pressure effect, while P-component contributes to amyloid deposition by stabilizing fibril amyloid protein and decreasing their clearance.
Beta pleated, metachromasis, PAS +ve
Congophilic, beta pleated, PAS +ve
Beta pleated, fibrillary, congophillic
Alpha pleated, small fibrils