BRAF gene mutation is seen in
Somatic activating mutations in the proto-oncogenes BRAF or NRAS are observed in a high propoion of melanomas. These mutations, which promote cellular proliferation and survival by activating the extracellular signal-regulated protein kinase (ERK) pathway, generally are mutually exclusive, since BRAF functions downstream of RAS. (Robbins Basic Pathology, 9 th edition. page : 867)
Breast carcinoma
Melanoma
Osteosarcoma
Prostate carcinoma
General pathology