Which type of cells are prominently infiltrated in Rheumatoid arthritis?
(B) T-cells[?]Role of T cells in RAoProminent T-cell infiltrate in RA synoviumoGenetic similarities between RA patients-Specific human leukocyte antigen (HLA)-DR genes - HLA DR4, DR14 and DR1oShared Epitope: The third hypervariable region of DR b chains, especially amino acids 70 through 74.oCD4+ T helper (Th) cells may initiate the autoimmune response in RA by reacting with an arthritogenic agent, perhaps microbial or a self-antigenoSynovial lining or intimal layer: Normally, this layer is only 1-3 cells thick. In RA, this lining is greatly hypertrophied (8-10 cells thick).oPrimary cell populations in this layer are fibroblasts and macrophages.
B cells
T-cells
NK-cells
Both B & T Cells
Immunity