Which of the following is not true regarding Medullary Ca thyroid?
Medullary thyroid cancer (MTC) originates from the parafollicular cells (C cells), which produce the hormone calcitonin. Approximately 25% of medullary thyroid cancer is genetic in nature, caused by a mutation in the RET proto-oncogene. When it coexists with tumors of the parathyroid gland and medullary component of the adrenal glands (pheochromocytoma) it is called multiple endocrine neoplasia type 2 (MEN2). The majority of C cells are located at the junction of the upper third and lower two thirds of the thyroid gland; hence, this is the most common location of MTC. On FNAC, MTC is characterized by the presence of stromal amyloid and the absence of thyroid follicles.
Hereditary
Secrets calcitonin
Hormone dependant
Amyloid stroma