All of the following are true statements about membranous nephropathy except?
Type I MPGN is characterized by the presence of discrete subendothelial electron-dense deposits of IgG and C3 (deposited in a granular pattern seen on IF). Membranous nephropathy Diffuse thickening of the glomerular capillary wall due to the accumulation of deposits containing Ig along the subepithelial side of the basement membrane. Basement membrane material is laid down between these deposits, appearing as irregular spikes protruding from the GBM, best seen by silver stains. Results in nephrotic syndrome (selective proteinuria) Primary cause :Idiopathic (75%) Secondary cause : Hepatitis B/C infection SLE/ Diabetes mellitus Drugs (NSAIDs, gold, captopril, etc.) Cancers (malignant melanoma)
Irregular 'spikes' on silver staining
Selective proteinuria
Granular subendothelial IgG accompanied by C3 deposits
SLE is a secondary cause
Membranous Glomerulopathy and Membranoproliferative Glomerulopathy