C- peptide is seen:-
- Insulin is synthesized in BETA- cells of pancreas by usual cell machinery for protein synthesis. - Beginning with translation of insulin RNA by ribosomes attached to E.R to form pre proinsulin. - Pre proinsulin is cleaved in E.R to form pro-insulin. - Insulin & C peptide are packaged in secretory granules & secreted in equimolar amounts. - So, c - peptide levels can be measured by radioimmunoassay in insulin-treated diabetic patients to determine how much of their own natural insulin they are still producing
In pre-proinsulin
In Proinsulin
As a combined entity with insulin after secretion
As a gastrointestinal proactive molecule
NEET 2019