Acquired mutations in PIGA  gene gives rise to :
Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic anemia that stems from acquired mutations in PIGA, a gene required for the synthesis of phosphatidylinositol glycan (PIG), which serves as a membrane anchor for many proteins. Because PIGA is X-linked, normal cells have only one active PIGA gene, a mutation of which is sufficient to cause PIGA deficiency.
Paroxysmal Nocturnal Hemoglobinuria
Hereditary Spherocytosis
Isoimmune hemolytic anemia
Fanconi’s anemia