Anti cancer drug causing nephrotoxicity -
Ans. is 'c' i.e., Cisplatin Platinum compoundo These are alkylating agents and act by similar mechanism,o Drugs are -First generation-CisplatinSecond generation-CarboplatinThird generation-OxaliplatinSide effects of Cisplatino Vomitingo Ototoxicityo Hyperuricemiao Nephrotoxicityo Neuropathy Note-o Cisplatin is most nephrotoxic where as carboplatin is more hematotoxic (bone marrow suppression),o Carboplatin has less nephrotoxic, neurotoxic and ototoxic effects,o Dose limiting toxicity of oxaliplatin is neurotoxicity (Peripheral neuropathy).
Cyclophosphamide
Busulfan
Cisplatin
Procarbazine
Anti-Neoplastic Agents