All of the following conditions are observed in Gout except:-
Answer is B (Deficiency of enzyme Xanthine oxidase): Deficiency of enzyme xanthine oxidase does not lead to gout. Xanthine oxidase is the enzyme that is needed for synthesis of uric acid from purine. Deficiency of xanthine oxidase will result in decreased formation of uric acid and hence will not lead to gout, rather this shall prove protective in gout. Allopurinol is a xanthine oxidase inhibitor that mimic's the deficiency of xanthine oxidase and is actually used in treatment of gout.
Uric acid nephrolithiasis
Deficiency of enzyme Xanthine oxidase
Increase in serum urate concentration
Renal disease involving interstitial tissues