All are uses of metronidazole except ?
Ans. is 'd' i.e., Malaria Metronidazole It has broad spectrum antiprotozoal activity against trichomonas, E. histolytica and G. lamblia. It is also active against many anaerobic bacteria. It does not affect aerobic bacteria. It acts by inhibiting pyruvate : Ferredoxin oxidoreductase (PFOR) enzyme pathway of pyruvate oxidation in anaerobes. In protozoa the mechanism of action is different, i.e. damage to DNA. Metronidazole is a nitroimdazole, nitro group is activated by reduction to form reactive cytotoxic product that damages the DNA. It inhibit cell mediated immunity to induce mutagenesis and causes radiosensitization. Uses Amoebiasis Pseudomembranous enterocolitis. Giardiasis Ulcerative gingivitis, trench mouth. Trichomonas vaginitis H. pylori gastritis, peptic ulcer. Anaerobic bacterial infection
Amoebiasis
Giardiasis
Trichomonas vaginitis
Malaria