All of the following cause inhibition of CYP3A except.
Ans. (A) Saquinavir(Ref: Katzung 11th/e p58, 863)All the drugs given in the options are microsomal enzyme inhibitors. Among protease inhibitors, ritonavir is the strongest inhibitor of CYP3A4 enzymes whereas saquinavir is the weakest.
Saquinavir
Ritonavir
Itraconazole
Erythromycin
Chemotherapy: General Principles