Which of the following is the most common hematological malignancy in children with Down syndrome?
Children with trisomy 21 have a high risk of developing leukemia. There is 20-fold increased risk of developing acute B lymphoblastic leukemias. There is 500-fold increased risk of acute myeloid leukemias, most commonly, acute megakaryoblastic leukemia.
T-cell acute lymphoblastic leukemia
Burkitt leukemia
Acute promyelocytic leukemia
Acute megakaryoblastic leukemia
Specific Cytogenetic Disorders