All of these are true about GnRH analogues used in treatment of endometriosis , EXCEPT?
GnRH is given continuously to downregulate and suppress pituitary gonadotropins and cause atrophy of endometriotic tissue. The risk of osteoporosis increases after prolonged use as the estrogen mediated osteoblastic action stops while the estrogen independent osteoclast action continues Add back therapy is given to reduce the risk of hypoestrogenic side effects like osteoporosis, hot flushes, vaginal dryness, urogenital atrophy. Drugs include: progesterones, low dose estrogens, tibolone Discontinuation causes recurrence within a year in upto 50 % cases Commonly used GnRH agonists are: Leuprolin Naferelin Goserelin Buserelin
Continuous administration causes downregulation of pituitary gonadotropins
The risk of osteoporosis decreases with prolonged use as the estrogen mediated osteoblastic action continues
Add back therapy includes estrogens
Discontinuation causes recurrence
Endometriosis, Adenomyosis