About first-order kinetics, the true statement is
Most of the drugs follow 1st order kinetics in 1st order kinetics-clearance is constant and, elimination is not saturable, and the rate of drug elimination is directly propoional to the concentration. This is usually referred to as first-order elimination Reference: Katzung Pharmacology; 13th edition; Chapter 3; Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action
Clearance remains constant
Fixed amount of the drug is eliminated
Half life increase with dose
Decreased clearance with increasing dose
General anatomy