Hydrochlorothiazide works by inhibiting
Thiazide diuretics: Inhibits Na-Cl- sympoer in early DCT acts on distal tubule Includes- chlorothiazide, indapamide Decreases Na+, K+, Mg2+, H+ Increases glucose, uric acid, lipid Increase in calcium - used in osteoporosis Name Site of action Example Mechanism Loop diuretics Thick ascending limb of Loop of Henle Furosemide, Torsemide Na-K-2Cl sympoer inhibition Carbonic anhydrase inhibitors PCT Acetazolamide, Dorzolamide, Brinzolamide Carbonic anhydrase inhibition Thiazides DCT Hydrochlorothiazide, Chlohalidone Na-Cl sympoer inhibition Osmotic diuretics Non-specific Mannitol By osmotic effect Epithelial sodium channel blockers Collecting duct Amiloride, Triamterene eNa channel blockade Aldosterone antagonists Collecting duct Spironolactone, Eplerenone Antagonism of aldosterone receptors
Na+ CI pump in late DCT
Na+ CI pump in early DCT
Na+ K+ 2CT pump in descending limb of loop of Henle
Na+K+2CT pump in ascending limb of loop of Henle
FMGE 2019