Cyclosporine in nephrotic syndrome acts by -
Ans. is 'a' i.e., Inhibiting calcineurin Stroid dependent nephrotic syndromeo The treatment options for steroid resistant nephrotic syndrome are:i) Calcineurin inhibitors (cyclosporine, Tacrolimus)ii) IV or oral cyclophosphamideiii) Levamisoliv) Mycophenolatev) Pulse corticosteroido All above immunosuppressants are used along with corticosteriods (Prednisolone or methylprednisolone).o Cyclosporine and cyclophosphamide are most commonly used.o Despite these options, there is lack of consensus on first line appropriate therapy for steroid resistant nephrotic syndrome.
Inhibiting calcineurin
Inhibition of GMPD
Acts as an alkylating agent
Antibiotic
Nephropathy