Preformed antibodies cause
Rejection- Antibody mediated Humoral or hyperacute rejection When preformed antidonor antibodies are present in circulation of recipient Previous rejection of a transplant Multiparous women Prior blood transfusions Mechanisms of injury - complement dependent cytotoxicity, inflammation, ADCC. Target is graft vasculature - rejection vasculitis
Hyperacute rejection
Acute rejection
Chronic rejection
Acute humoral rejection
General pathology