Expected change in Vitamin B,2 deficiency
Ans. is 'b' i.e., Increased methylmalonic acid in urine Isomerization of methvlmalonyl CoA to succinyl CoAIn this reaction, active form of vitamin BI2 is deoxyadenosyl cobalamine.Propionyl-CoA is produced as catabolic end product of some alipathic amino acids andb-oxidation of odd chain fatty acids.Propionyl CoA is then conveed to succinyl CoA through methylmalonyl-CoA.Thus methylmalonyl-CoA is accumulated and excreted in urine as methylmalonic acid (methylmalonate) in vitamin B12 deficiency, i.e. methylmalonic aciduria.
Increased homocysteine in urine
Increased methylmalonic acid in urine
FIGLU in urine
Phenylalanine in urine