The granuloma is characterized by
Granulomatous inflammation is a distinctive pattern of chronic inflammation characterized by aggregates of activated macrophages with scattered lymphocytes granuloma:-is an aggregation of macrophages surrounded by a collar of mononuclear cells principally lymphocytes Macrophages may get activated to form epithelioid cells Some of the cells may fuse together to form a bigger cell called a giant cell Older granulomas may have a rim of fibroblasts and connective tissue Common conditions resulting in granuloma formation with impoant features Tuberculosis Sarcoidosis (Non-caseating granuloma) Brucellosis Cat scratch disease (Stellate shaped or round granuloma) Syphilis (Gumma) Leprosy Inflammatory bowel disease ref pathology robbins 9th ed page 56
Focal accumulation of activated macrophages
Collection of neutrophils
Newly formed vessels
Collection of eosinophils
General pathology