True statement about diphtheria toxin is
Toxigenicity of the diphtheria bacilli depends on the presence in it of corynephages which acts as the genetic determinant controlling toxin production. The diphtheria toxin acts by inhibiting protein synthesis. Specifically, a fragment B heparin binding and fragment A inhibits polypeptide chain elongation in the presence of nicotinamide adenine dinucleotide by inactivating the elongation factor EF-2. Reference: Textbook of Microbiology; Anathanarayan and panicker&;s; 9th edition; Page no: 238
Toxin is phage mediated
Toxin is required for local infection
Endotoxaemia causes systemic manifestation
Toxin acts by inhibiting synthesis of capsule
Bacteriology