Which of the following anticancer drugs can cause a hypercoagulable state
L-asparginase causes the breakdown of aspargine and thus interferes with protein synthesis. It can inhibit the pro­duction of clotting factors (responsible for cerebral hemorrhage) as well as anti-clotting proteins (can lead to cortical vein thrombosis and other hypercoagulable states).
5–FU
L–asparginase
Melphalan
Carmustine