Which of the following pathway is seen in basal cell carcinoma
Answer- B. Sonic HedgehogBasal cell carcinomaLocally aggressive tumorAssociated with mutations which activate Hedgehog pathway signalling.Gorlin syndrome is associated with gene PTCH, a tumor suppressor genePTCh is receptor for Sonic hedgehog, which determines polarity during embryonic development.Basal cell carcinoma presents as pearly papules.
mTOR
Sonic Hedgehog
WNT
RAS