Methotrexate mechanism of action:
Ans. (a) Inhibit dihydrofolate ReductaseRef. KD Tripathi 6th Ed. / 823METHOTREXATE (MTX)DHFADHFRase---------------THFA* Methotrexate is a highly efficacious antineoplastic drug which inhibits dihydrofolate reductase (DHFRase) enzyme- blocking the conversion of dihydrofolic acid (DHFA) to tetrahydrofolic acid (THFA).* This conversion is essential for formation of an essential coenzyme required for one carbon transfer reactions in denovo purine synthesis and amino acid interconversions.* Methotrexate has cell cycle specific action kills cells in S phase; primarily inhibits DNA synthesis.Also Know*Drug of choice for Mtx toxicity: FOLINIC ACID.
Inhibit dihydrofolate reductase
Stimulate dihydrofolate reductase
Inhibit tetrahydrofolate reductase
Stimulate tetrahydrofolate reductase
Anti-Neoplastic Agents