A female child with virilization, hypeension with low plasma renin diagnosis is
Renin is produced from the juxta glomerular cells in the kidney. It acts on the angiotensinogen produced in the liver and conves it to angiotensin I. The latter is conveed to Angiotensin II by the Angiotensin conveing enzyme in the lung. Angiotensin II is a potent vasoconstrictor and acts on the angiotensin receptors. Both high as well as low levels of renin may be associated with hypeension. This aicle deals with hypeensive disorders associated with low renin levels The causes of low renin hypeension are as follows: Low renin essential hypeension (LREH) Primary aldosteronism Conn's syndrome Glucocoicoid-remediable (GRH)/Familial hyperaldosteronism Type I Familial Type II Liddle syndrome Mineralocoicoid receptor mutation Apparent mineralocoicoid excess (AME) Glucocoicoid resistance Gordon syndrome Congenital adrenal hyperplasia (CAH) 11 beta hydroxylase deficiency Ref Robbins 9 /e pg 158
21 alpha hydroxylase deficiency
11 beta hydroxylase deficiency
3 beta hydroxylase deficiency
Conn's syndrome
Genetics