True about myasthenia gravis
*The weakness increase during repeated use and may improve following sleep or rest.only 10% of cases are associated with thymomas 65% with hyperplasia of thymus. Edrophonium test is positive. In electrodiagnostic testing MG patients show a rapid reduction of >10-15% in the amplitude of evoked response. Ref Harrison20th edition pg 2445
Associated with thymomoa in 3/4 of cases
Incremental response seen with repetitive electric stimuli
Skeletal muscle function improve after rest
Edrophonium test negative
C.N.S