When nitrates are combined with Calcium channel blockers
Really Kk sharma 1e p276 Recommendations for combination therapy decisively depend on the choice of the first-line drug. Only nitrates reduce myocardial preload by venodilation and substitute for EDRF-deficiency. ... Therefore, the combination of nitrates with hea-rate-increasing calcium channel blockers, such as nifedipine, should be avoided.
Aerial pressure will decrease
Hea rate will increase
Ejection time will decrease
End diastolic volume will increase
General anatomy