What is the primary toxicity of busulfan
Busulfan It is highly specific for myeloid elements( doses myelosupression occurs); granulocyte precursors being the most sensitive, followed by those of platelets and RBC. It produces little effect on lymphoid tissue and g.i.t. Side effects:- Hyperuricaemia is common; pulmonary fibrosis and skin pigmentation are the specific adverse effects. Sterility also occurs. Uses It is the drug of choice for chronic myeloid leukaemia. Ref:-kd tripathi; pg num:-861
Lung fibrosis
Severe myeloidsupression
Cystitis
Hyperuricaemia
Chemotherapy