Which of the following is calculated as the ratio of the area under the curve (AUC) obtained by oral administration vs. the AUC for intravenous administration of the same drug?
bioavailabilitygenerally refers to the fraction of drug absorbed systemically, and is thus available to produce a biological effect. This is often measured by quantifying the "AUC". In order to determine the respective AUCs, the serum concentration vs. time plots are typically gathered using C-14 labeled drugs and AMS (accelerated mass spectroscopy). Ref k d tripati 6/e p27
Absorption
Bioavailability
Clearance
Elimina on rate constant
General pharmacology