All are true about Wilson's disease except
Refer Robbins page no 849 Free copper dissociates and is taken up by hepatocytes. In the liver copper binds to an a2-globulin (apoceruloplasmin) to form ceruloplasmin, which is secreted into the blood. Excess copper is transpoed into the bile. Ceruloplasmin accounts for 90% to 95% of plasma copper. Circulating ceruloplasmin is eventually desialylated, endo- cytosed by the liver, and degraded within lysosomes, after which the released copper is excreted into bile. This degradation/excretion pathway is the primary route for copper elimination. The estimated total body copper is only 50 to 150 mg
Increase in liver Cu
Increase in urine Cu
Increase in Ceruolplasmin
Increase in serum Cu
miscellaneous