A 10 yr old boy with mass in the abdomen. On imaging the paraaortic LN is enlarged. On biopsy starry sky appearance is seen. What is the underlying abnormality?
Ans. (d) Translocation involving MYC gene(Ref: Robbins 9th/pg 597; 8th/607)Macrophages with abundant clear cytoplasm showing: characteristic "starry sky" pattern are seen in Burkitt lymphoma
p53 gene mutation
RB gene mutation
Translocation involving BCR-ABL genes
Translocation involving MYC gene
Misc. (W.B.C)