glipizide differs from chlorpropamide in that it:
(Ref: KDT 6/e p266) Second generation (like glipizide) sulfonylureas are more potent than first generation agents (like chlorpropamide). Chlorpropamide is the longest acting sulfonylurea. Sulfonylureas can cause hypoglycemia (even in non-diabetics) due to release insulin.
Is more potent
Is longer acting
Does not lower blood sugar in nondiabetic subjects
Is less prone to cause hypoglycemic reaction
Other topics and Adverse effects