TRUE about Heparin Indiced Thrombocytopenia (HIT) syndrome are all, EXCEPT:
Frequency of HIT after exposure to unfractionated heparin (UFH) is 1% to 5%, whereas the frequency of HIT associated with the used of low-molecular-weight heparin (LMWH) is only 1%. HIT occur due to the formation of antibodies against the complex of heparin bonded to platelet factor 4. Most patients develop HIT after exposure to heparin for 4 days but may occur suddenly in patients with recent exposure (< 100 days). It is paradoxically associated with increased risk of aerial and venous thrombosis. The 4 "T"s have been recommended to be used in a diagnostic algorithm for HIT: thrombocytopenia, timing of platelet count drop, thrombosis and other sequel such as localized skin reactions, and other cause of thrombocytopenia not evident.
LMWH shouldn't be used for treatment
It causes both aerial and venous thrombosis
More common with fractionated heparin
Occurs commonly in about a week of heparin therapy