A male with insulin-dependent diabetes and having macular edema develops glaucoma. Which drug should be used as the least resort to treat?
Ans. B. Prostaglandin analoguesAlthough prostaglandin analogues are the first-line treatment for open angle glaucoma, these should not be given in case a patient with macular edema develops glaucoma. The reason for the same is maculopathy caused by prostaglandin analogues (can cause blurring of vision).Extra Edge: Other drugs causing maculopathy* Niacin* Griseofulvin* Thiazolidinediones* Tamoxifen* Clofazimine, chloroquine (Bulls' eye maculopathy)* PG analoguesDrugs used for treatment of macular degeneration* Monoclonal antibodies: Bevacizumab, Ranibizumab* Photodynamic therapy: Verteporfin* Steroids (Dexamethasone, Prednisolone)* I/V Methotrexate* Pegaptanib: PEGylated oligonucleotide that binds VEGF
Alpha agonist
Prostaglandin analogue
Pilocarpine
Beta blocker
A.N.S.