Proton pump inhibitors are most effective when they are given -
Ans. is 'b' i.e., Sholy before meals o Bioavailibility of all PPIs is reduced by food; they should be taken in empty stomach, followed 1 hour later by a meal to activate 1-1+ ATPase and make it more susceptible to the PPI. o PPIs should be administered approximately 1 hour before a meal (usually breakfast) so that the peak serum concentration coincides with the maximal activity of proton pump secretion.
After meals
Sholy before meals
Along with H2 blockers
During prolonged fasting periods