Not true regarding serotonin syndrome is:
Dantrolene is not the treatment of choice, though it is at times used to control the hypehermia. Serotonin Syndrome: It is predictable not idiosyncratic Neurotransmitter Basis Serotonin (5-HT) increase Causative Agents SSRI + MAOI (e.g., phenelzine) SSRI + serotonergic pain medication (e.g., meperidine, tramadol) SSRI + cough suppressant (e.g., dextromethorphan) Symptoms 1. Fever2. Autonomic instability3. Diarrhea4. Myoclonus5. Mental status changes6. Hyperkinesia7. Rapid onset Lab Findings No change in CPK or liver enzymes Management Stop agentSuppoive treatment and antiserotonin agent (e.g., cyproheptadine)
It is predictable and not idiosyncratic
SSRIs and MAOIs cause it
IV dantrolene is the treatment of choice
Hypeension, hypehermia and hyperrelfexia are the signs
Mood Disorders