Regarding termination of drug action
Ref-KDT 6/e p23 Action of drug can be terminated by hepatic metabolism or by anal excretion. Most of the dexa inactivated by metabolism. However some Ducks may be activated from inactive form (prodrugs) and others may produce active metabolite Some drugs main activate from Blood example decoction lives bloodstream and enters the hea to produce it's action
Drugs must be excreted from the body to terminate their action
Metabolism of drugs always abolishes their Pharmalogical activity
Hepatic metabolism and renal excretion are the two most impoant mechanism involved
Distribution of a drug out of bloodstream terminated drugs effect
Other topics and Adverse effects