Flare response in triple response occurs due to
When the skin is stroked more firmly with a pointed instrument, instead of the white reaction there is reddening at the site that appears in about 10 s (red reaction). This is followed in a few minutes by local swelling and diffuse, mottled reddening around the injury. The initial redness is due to capillary dilation, a direct response of the capillaries to pressure. The swelling (wheal) is local edema due to increased permeability of the capillaries and postcapillary venules, with consequent extravasation of fluid. The redness spreading out from the injury (flare) is due to aeriolar dilation. This three-pa response--the red reaction, wheal, and flare--is called the triple response and is pa of the normal reaction to injury Ref: Ganong&;s Review of medical physiology 25th edition. Page: 613
Vasodilation due to release of secondary mediators
Chemotaxis, adhesion of leucocytes to vessel wall
Direct vessel injury
Increased permeability
Cardiovascular system