Which of the following increases the susceptibility to coronary aery disease :
Answer is C (Nephrotic syndrome) Nephrotic syndrome is associated with hyperlipidemia with an increased level of LDL and cholesterol in most patients. This hyperlipidemia may accelerate atherosclerosis and increase the susceptibility to coronary aery disease Type V hyperlipoprotenemia is associated with normal / low levels of LDL and does not appear to increase the risk of CHD. Hyperlipidemia in Nephrotic syndrome ma). accelerate Atherosclerosis Hyperlipidemia is pa of the clinical complex of Nehrotic syndrome Hyperlipedemia in Nephrotic syndrome is a consequence of increased hepatic lipoprotein synthesis Low density lipoproteins and cholesterol are increased in majority of patients This Hyper lipidemia may accelerate atherosclerosis and progression of Renal disease - Harrison's Hyperlipidemia in Type B hyperlipoprotenemia does not appear to increase risk of CHD This disorder does not appear to increase risk of CHD either because large trylyceride rich lipoproteins are not atherogenic or because only normal amount of LDL can be generated Condition Risk Of Coronary Aery Disease Type I (Familial Hyper Chylomicronemia) Not increased Type II A (Familial Hyper Cholesterolemia) Accelerated Type II B (Familial Combined Hyperlipidemia) Accelerated Type III (Familial Dysbetalipoprotenemia Accelerated Type IV (Familial Hyper Triglyceredemia) Accelerated Type V (Familial Mixed Hyperiglyceredemia) Not increased Hyperlipidemia in type V hyperlipoprotenemia is not associated with increased LDL Type V hyper liprotenemia : VLDL and Chylomicrons are increased LDL is normal or decreased Nephrotic syndrome is a clinical complex characterized by - Proteinuria Hypoalbuminemia Edema Hyperlipidemia / Lipiduria
Type V hyperlipoproteinaemia
Von willebrands disease
Nephrotic syndrome
Systemic lupus erythematosus