Which of the following provides the best explanation for neostigmine being preferred over physostigmine for treating myasthenia gravis?
Neostigmine is a quaternary ammonium derivative and is water soluble. Its absorption from GIT and penetration in the brain and cornea is much less than physostigmine. It produces additional action on NM receptors.
It is better absorbed orally
It has longer duration of action
It has additional direct agonistic action on nicotinic receptors at the muscle end plate
It penetrates blood brain barrier
Parasympathetic System & Glaucoma