The initiating mechanism in endotoxic shock is
ref Robbins 9/e p131-132 The principal mechanism for septic shock includes: Peripheral vasodilation and pooling of blood Endothelial activation/injury Leukocyte induced injury Disseminated intravascular coagulation Activation of cytokine cascades
Peripheral vasodilation
Endothelial injury
Increased vascular permeability
Reduced cardiac output
General anatomy