Insulin sensitivity increases with following treatment except:
Ans: D (Fasting) Ref: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed, 2011 Pg 1246. 1258. 1264.1270Explanation:Insulin sensitivity refers to the amount of glucose that can be cleared from the blood with a given dose of insulin Insulin sensitivity may be altered b\ age. body weight, exercise, diseases and drugs. Active persons are found to be more sensitive to insulin compared to those with sedentary life style. Insulin sensitivity has been found to be inversely related to age with insulin resistance more common in the elderly due to reduced physical activity.In hyperglycemic state, metformin decreases blood glucose by lowering hepatic glucose production and enhancing peripheral glucose uptake. This is attributed to increase in insulin sensitivity and reduction in insulin resistance.Acarbose an u-glucosidase inhibitor by reducing postprandial plasma glucose increases the release of glucoregulatory hormone. GLIM. As a result acarbose increases insulin sensitivity and reduces blood glucose.Easting leads to hypoglycemia which is associated with reduction of insulin secretion and the release of counter regulatory hormones namely epinephrine, glucagon, glucocorticoids etc. Hence the answer to above question is fasting which does not increase insulin sensitivity.
Metformin
Acarbose
Exercise
Fasting
Endocrinology