A 72-year-old female presents with complaints of generalized lymphadenopathy. Her CBC showed total WBC count of 80,000. Flow cytometry revealed CD19 CD20, CD 5 +, CD 23 -ve. Cyclin D1 + GI examination was done and biopsy was taken. Peripheral blood smear Which of the following genetic abnormality one may expect to find in this condition?
1st image shows the small to intermediate sized cells with cleaved nuclei. 2nd image shows Lymphomatoid polyposis. Mantle cell lymphoma is a B cell lymphoma with CD5+ but CD 23-ve. It shows cyclin D1 positivity and lymphomatoid polyposis. t(11:14) leads to overexpression of cyclin D1- involved in mantle cell lymphoma. t(11:18) in marginal zone lymphoma t(14:18) in follicular lymphoma. Deletion of 13q Is seen in CLL and multiple myeloma.
t(8:21)
13q deletion
t(11:14)
t(11:18)
Integrated QBank