Complete deficiency of UDP glucoronyl transferase (UGT) is seen in:
UGT1A1, generated from the UGT1A1 gene, is responsible for bilirubin glucuronidation. Mutations of UGT1A1 cause hereditary unconjugated hyperbilirubinemias: Crigler-Najjar type 1 is caused by severe UGT1A1 deficiency and is fatal around the time of bih, Crigler-Najjar type II and Gilbe syndrome there is some UGT1A1 activity and the phenotypes are much milder
Criggler - Najjar Type I
Criggler - Najjar Type II
Gilbe's syndrome
Dubin-Johnson syndrome
Bilirubin Metabolism