The anti- acetylcholine receptor (AChR) antibodies in myasthenia gravis reduce the number of available AChRs at neuromuscular junctions with which of the following mechanism ?
The anti-AChR antibodies reduce the number of available AChRs at NMJs by three distinct mechanisms: (1) accelerated turnover of AChRs by a mechanism involving cross-linking and rapid endocytosis of the receptors; (2) damage to the postsynaptic muscle membrane by the antibody in collaboration with complement; and (3) blockade of the active site of the AChR. Ref harrison 20th edition page 3232
accelerated turnover of AChRs
damage to the postsynaptic muscle membrane
blockade of the active site of the AChR
all of the above
C.N.S