Hypersensitivity Pneumonitis is classically described as a:
Answer is C (Immune complex) Hypersensitivity pneumonitis is an immunologically mediated response to an extrinsic antigen that involves both immune complex (Type III) and cell mediated (Type IV) hypersensitivity reactions. Classically however, Hypersensitivity pneumonitis was believed to be a immune complex (Type III) mediated hypersensitivity response which is therefore the better answer amongst the options provided. However in strict terminology both option C and D should be correct. Types of Hypersensitivity Reactions: Review Type I Hypersensitivity (IgE)Q Type II Hypersensitivity (IgG & IgM)Q Cytotoxic, complement mediated lysisQ Includes.- * Local: Eczema, Hay fever, Asthma (Atopy).Q * Systemic: Anaphylaxis. Examples based on type 1.11S Q: Includes: * Complement mediated lysisY * Antibody dependent cell mediated toxicity (formerly classified as type * Changes in cellular function (former type V).Q - Increased function: Grave's disease.Q - Decreased function: M. Gravis.e * PhagocytosisY Examples includes: 1).Q * Theoblad Smith phenomenon:Q This is anaphylaxis in guinea pigs. * PK reaction (Prusnitz Kunster):Q Demonstrate that IgE is homocytotropic i.e. species specific. * Casoni's test: Immediate type (IgE) H.S * Those with Ag on RBC. - Blood transfusion reaction.Q - Hemolytic anemia e.g. with I.M. and mycoplasma.Q * Those with Ag on Neutrophils: Agranulocytosis.Q * Those with Ag on platelets: e.g. 1TP.Q * Those with Ag on basement membrane: Goodpasture'sQ Type III Immune complex (IgM & IgG) Type IV Delayed hypersensitivity (cellular immunity) Includes: * Local: Ahus reactionY * Systemic: Serum sickness.Q Examples: Includes: * Tuberculin test.Q * Lepromin test.Q * Contact dermatitis.Q * Jones-Mote reaction (cutaneous basophilic hypersensitivity).Q * Graft rejection (chronic).Q * Shick's test.Q * Post streptococcal G.N.Q * Detected by RAJ1 Assay.Q Hyprsensitivity Pneumonitis is associated with both Type III and Type IV Hypersensitivity
Type I hypersensitivity reaction
Tye II hypersensitivity reaction
Type III (Immune complex) Hypersensitivity
Type IV (Cell mediated) Hypersensitivity