Aganglionic segment is encountered in which pa of colon in case of Hirschsprung's disease ?
Ans. is 'a' i.e., Distal to dilated segmentCongenital aganglionic megacolon (Hirschsprung disease) Hirschsprung disease is a congenital disorder characterized by aganglionosis of a poion of the intestinal tract.An intestinal segment lacks both Meissner submucosal and Auerbach myenteric plexuses. This loss of enteric neural coordination leads to functional obstruction and intestinal dilation proximal to the affected segment.Histological findings are ?i) Absence of ganglion cells and ganglia in the muscle wall and submucosa of the affected segment. Thickening and hyperophy of nerve trunk.ii) Rectum is always affected with involvement of more proximal colon to variable extent --> most cases involve the rectum and sigmoid only.o Proximal to the aganglionic segment, the colon undergoes progressive dilation and hyperophy. o With time, the proximal innervated colon may become massively distended --> megacolon.
Distal to dilated segment
In whole colon
Proximal to dilated segment
In the dilated segment