All of the statements are true about FLUORO QUINOLONES, except -
Ans. is 'd' i.e., Increased Neuromuscular blocking action Fluoroquinolones are contraindicated in children < 18 years of age, because of evidence in animals of cailage damage in developing joints. o They are contraindicated in pregnancy because of concerm for the developing fetus (teratogenicity) o Fluoroquinolones are enzyme inhibitors and thus inhibit the metabolism of many drugs. Plasma concentration of theophylline is increased because of inhibition of its metabolism and this results in theo phylline toxicity. Fluoroquinolenes have no N-M blocking propeies. Antibiotics with N.M blocking propey are o Aminoglycosides o Polypeptide antibiotics o Lincomycin o Tetracyclines o Clindamycin
Suspected of having teratogenic potential
Ahropathy of limb-in children may occur
Increase theophylline toxicity
Increase neuromuscular blocking action