An old man, Om prakash presented with anorexia, weakness and paraesthesia. On fuher investigation his hemoglobin came out to be 5.8 g% and the peripheral smear showed the presence of macrocytes and neutrophils having hypersegmented nuclei. His tendon reflexes also were sluggish. Endoscopy revealed atrophic gastritis. Deficiency of which of the following factors can lead to such a clinical situation?
Diagnosis of the patient is pernicious anemia. Factors ouring this diagnosis are: Megaloblastic anemia. Demyelination (decreased tendon reflexes) Atrophic gastritis So, he would require parenteral vitamin B12 supplementation.
Folic acid
Vitamin B12
Pyridoxine
Riboflavin
Hematology