For which of the following seizures would carbamazepine, phenytoin, and primidone be prescribed as the appropriate drug treatment for prevention?
Generalized tonic-clonic seizures are convulsive and can be the result of paial seizures. Carbamazepine, phenytoin, and primidone are among the drugs recommended for generalized seizures. Primidone is a prototype deoxy barbiturate. Phenytoin is a hydantoin and these drugs are highly fat soluble. They stabilize membranes by decreasing Na+ conductance during the period of high-frequency firing. Ref: Greenberg D.A., Aminoff M.J., Simon R.P. (2012). Chapter 12. Seizures & Syncope. In D.A. Greenberg, M.J. Aminoff, R.P. Simon (Eds), Clinical Neurology, 8e.
Complex paial
Simple paial
status epilepticus
Generalized tonic clonic