Hanup disease is mainly due to:
Hanup's disease is an autosomal recessive disorder, in which there is: * Defect in neutral amino acid transpoer (tryptophan) * Failure to absorb tryptophan from intestine and also reabsorb it from kidneys =Clinical feature: Aminoaciduria i.e. tryptophan in urine Pellagra (niacin deficiency ) like symptoms (neurological and dermatologic), despite an adequate intake of both tryptophan and niacin. NORMAL AND ABNORMAL ROUTES OF TRYPTOPHAN METABOLISM
Niacin deficiency
Defective transpo of tryptophan
Defective serotonin biosynthesis
Thiamine deficiency
Tryptophan metabolism detail