True about hyperophic scar
Ans is 'b' i.e. More common in blood group A Etiology of hyperophic scarsThey follow damage to deep dermisAutosomal dominant with incomplete inheritance.Associated with HLA B14, B21, Bw16, Bw35, DR5 & DQw3.They are more common in people with 'A' blood group. PathophysiologyHigh level of production of collagen, elastin, fibronectin, proteoglycan & hyaluronic acid by fibroblast.Collagen produced is predominantly type I.There is increased level of TGE-131, P2, activin A, IFN-a & y, plasminogen activator inhibitor 1(PAI1) & low level of urokinaseIL-6 plays a key role in keloid formation.
No genetic predisposition
More common in blood group A
No HLA association
Predominantly collagen type 4