About lidocaine all are true, except
Local anaesthetics are poorly water-soluble and this limits their renal excretion to less than 5%. For treating ventricular arrhythmias initial loading dose is to be followed by infusion. The amides are so stable that they are not effected even by autoclaving. Effective refractory period (of cardiac tissue) is prolonged by local anaesthetics.
Dose need to altered in renal failure
Loading dose before infusion
It is little effected by heat & pH
Prolongs refractory period
All India exam