Most common Cause of fracture in hemophilic ahropathy
Hemophilic ahropathy is a disabling condition characterized by joint impairment, chronic pain, and reduced quality of life . Recent evidence indicates that intra-aicular inflammation and angiogenesis may be pivotal processes in the pathogenic cascade of hemophilic ahropathy . Joint bleeding ors iron release from hemoglobin, thus inducing a chronic inflammatory process mediated by cytokines and pro-angiogenic factors and consequently leading to progressive synol pannus growth and aicular cailage damage . Spontaneous joint bleeding and repeated hemahroses lead to hemophilic ahropathy--a debilitating disease with a significant negative impact on mobility and quality of life. Iron, cytokines, and angiogenic growth factors play a pivotal role in the onset of the inflammatory process that involves the synol tissue, aicular cailage, and subchondral bone, with early damages and molecular changes determining the perpetuation of a chronic inflammatory condition. Synovitis is one of the earliest complications of hemahrosis, and is characterized by synol hyperophy, migration of inflammatory cells, and a high degree of neo-angiogenesis with subsequent bleeding. Ref - pubmed.com <a href="
Osteoporosis & restrictive joint movement
Cailage destruction
inflammatory ahropathy
Osteosclerosis
Immune system