How does MDR gene act?
The multidrug resistance (MDR) gene encodes a protein that actively pumps drugs out of tumor cells. This gene confers resistance on a variety of antitumor drugs, including the antibiotics and plant-derived compounds. Tumor resistance to a given chemotherapeutic agent can often be overcome by the administration of multiple drugs. Ref: Sabel M.S. (2010). Chapter 44. Oncology. In G.M. Dohey (Ed), CURRENT Diagnosis & Treatment: Surgery, 13e.
Block drug activation
Block intracellular DNA synthesis
Cause efflux of drug
DNA repair inhibition