Growth hormone has its effect on growth through-
Ans. is 'b' i.e., IGF -1 o GH has two major functions:- The growth of skeletal system The growth is mediated by somatomedins (IGF). Increased deposition of cartilage (including chondroitin sulfate) and bone with increased proliferation of chondrocytes and osteocytes. Metabolic effects- most of the metabolic effects are due to the direct action of GH. These include gluconeogenesis, decreased peripheral utilization of glucose (decreased uptake), lipolysis and anabolic effect on proteins.
Directly
IGF -1
Thyroxine
Intranuclear receptors
Pituitary