A patient with recent onset primary generalized epilepsy, develops drug reaction and skin rash and neutropenia due to phenytoin sodium. The most appropriate course of action is:
(Ref: Katzung, 14th ed. pg. 418-19; KDT 6th ed. pg. 405)Hypersensitivity reactions like rashes, DLE, lymphadenopathy and neutropenia require that phenytoin to be stopped.
Shift to sodium valproate
Shift to clonazepam
Shift to ethosuximide
Restart phenytoin after 2 weeks
C.N.S