Botulinum toxin produces skeletal muscle paralysis by:
Ref: KD Tripathi pharmacology 7th edition (page.no: 99) Botulinum toxin A and B are highly potent exotoxins produced by Clostridium botulinum that is responsible for Botulism. These neurotoxic proteins cause long-lasting loss of cholinergic transmission by interacting with an axonal protein involved in the exocytic release of Ach
Enhancing release of norepinephrine
Inhibiting release of acetylcholine
Direct damage to nerve endings
Producing hemolysis
Autonomic nervous system