Hemolytic uremic syndrome
Hemolytic uremic syndrome: Caused by deficiencies of complement regulatory proteins or agents that damage endothelial cells, such as a Shiga-like toxin elaborated by E. coli strain O157:H7. The endothelial injury initiates platelet activation, platelet aggregation, and microvascular thrombosis. Ref: ROBBINS BASIC PATHOLOGY 10th ed Pg no: 491
Most commonly caused by verocytogenic E.Coli
Causes mild to severe coombs positive hemolytic anemia
Recurrences rare
Transient thrombocytopenia
Urinary tract