Which of the following statements about baricitinib is FALSE?
Baricitinib andtofacitinib are oral JANUS kinase inhibitors (JAK). These drugs are used in rheumatoid ahritis.Tofacitinib is also used in ulcerative colitis. Major side-effects of these drugs are:* Increased risk of infection: TB , Herpes zoster.* Increased risk of malignancy like Lymphoma.* Hyperiglyceridemia.They require dose reduction in kidney and liver failure. So, they are avoided in lymphopenia and anemia.So, the answer is 'B' because it is not used in Crohn's disease.
Oral JAK inhibitor
Approved for use in moderate to severe Crohn's disease
Increases triglycerides
Dose reduction is required in renal and hepatic impairement
Targeted Anticancer Drugs and Immunosuppressants