Grave’s disease; all are true except:
Clinical Features

Hyperthyroid symptoms (heat intolerance, increased sweating and thirst, weight loss despite adequate caloric intake)
Symptoms of adrenergic stimulation (palpitations, nervousness, fatigue, emotional liability, hyperkinesis and tremors)
Most common GI symptom is increased frequency of bowel movements and diarrhea.
	
Female patients often develop amenorrhea, decreased fertility and increased incidence of miscarriage.
Children experience rapid growth with early bone maturation.
Older patients present with CVS complications (AF and CHF).
Overt cardiac failure occurs in only 6-19%, increases with age


Weight loss, facial flushing, warm and moist skin, tachycardia, cutaneous vasodilatation, collapsing pulse is seen on examination.
A fine tremor, muscle wasting and proximal muscle group weakness with hyperactive tendon reflexes often are present.
	
Overlying bruit or thrill at upper pole due to increased vascularity.
Loud venous hum in supraclavicular space.
Ophthalmopathy (orbital proptosis) occurs in 50%, dermopathy in 1-2%.
Dermopathy is characterized by deposition of glycosaminoglycans, leading to thickened skin in pretibial region and dorsum of foot (pretibial myxedema)
Cardiac failure is common
Hypertrophy and hyperplasia or thyroid gland is due to TSH-Rab
Remissions and exacerbations are not infrequent
It is highly vascular with audible bruit