Warfarin induced skin necrosis is more common in patients with
It is due to decreased levels of protein C. It is more likely to occur in patients with genetic deficiency of protein C. Most common side effect of warfarin:Bleeding Dermal vascular necrosis is early appearing adverse effect. Due to decreased osteocalcin synthesis Warfarin causes nasal hypoplasia and therefore contraindicated in pregnancy
Protein C deficiency
Sickle cell anemia
Factor V leiden deficiency
Antithrombin 3 deficiency
Hematology