Recent oral direct thrombin inhibitor which can be used for prevention of stroke is:
Ans. (A) Dabigatran:(Ref: Katzung 11/e p594, CMDT 2012/537, KDT 8/e p671,672)Ximelagatran was the first oral direct thrombin inhibitor approved; however it was later withdrawn because of hepatotoxicity. Recently a new direct thrombin inhibitor dabigatran has been approved for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation. It is administered as a prodrug; dabigatran etexilate. It is not metabolized by CYP enzymes however dose adjustment is required in renal failure.
Dabigatran
Ximelagatran
Lepirudin
Saxagliptin
Anticoagulants and Coagulants