Wof is true regarding tolerance occurring in regular opium abusers
Tolerance and dependence :- High degree of tolerance can be developed to morphine and related opioids if the drug is used repeatedly. It is paly pharmacokinetic (enhanced rate of metabolism), but mainly pharmacodynamic (cellular tolerance). Tolerance is exhibited to most actions, but not to constipating and miotic actions. Addicts tolerate morphine in grams: lethal dose is markedly increased. Ref:- kd tripathi; pg num:-473
Tolerance develops to all actions of morphine
No tolerance occurs to euphoric and sedative actions of morphine
No tolerance occurs to constipating and miotic actions of morphine
Lethal dose of morphine is not significantly increased
Central Nervous system