Marker for the renal vasculitis in children is ?
Ans is 'a' i.e., Increased IgA o IgA nephropathy or Berger's disease affects children and young adult and is perhaps the most frequent type of glomerulonephritis in children. IgA nephropathy (Berger nephropathy) C.) It is the most common type of glomerulonephritis world wide. Children and young adults are commonly affected. o It occurs after an upper respiratory tract infection or gastrointestinal infection. Clinical presentation Gross hematuria within 1-2 days after on upper respiratory tract infection. This feature distinguish it from PSGN. In PSGN hematuria occurs 7-21 days after respiratory infection. o Can also present with nephritic or nephrotic syndrome. o Mild to moderate hypeension. Pathology o Focal and segmental mesangial proliferation. o IgA deposition in mesangium. o Serum complement level is normal. This feature also differentiates it from PSGN. In PSGN complement (C3) level is decreased. o Whereas IgA nephropathy is an isolated renal disease, similar IgA deposits are also found in systemic disorders of children like Henoch shonlein purpura, which also have renal vasculitis as a component In view of the high frequency of IgA nephropathy in children, IgA can be used as marker for renal vasculitis.
Increased IgA level
Low complement level
| Antineutrophilic cytoplasmic antibody titre
Increase antinuclear antibody