The plasma half life of aspirin:
Aspirin and other salicylates show saturation kinetics (zero order) and thus, their half life is not constant. Clearance at high doses (anti-inflamatory) is lesser than at low (analgesic) doses. Thus t1/2 is more for anti-inflammatory dose than for analgesic dose.
Is independent of dose
Is longer for anti-inflammatory doses compared to that for analgesic dose
Is shoer for anti-inflammatory doses compared to that for analgesic dose
Can be increased by alkalinizing the urine
NSAIDs, Gout and Rheumatoid Ahritis