Which of the following statements about changes in aicular cailage with aging is not TRUE?
In ageing there will be no increase in enzymatic degradation of proteoglycans. The enzymatic degradation is slow and constant throughout the life. Ref: Biology of Cailage Cells, Stockwell, R.A, 1976, 1st Edition, Page 245; Osteoahritis : A companion to Rheumatology, Elsevier, 1st Edition, 2007, Page 79.
Total proteoglycan content is decreased
Synthesis of proteoglycans is decreased
Total water content of cailage is decreased
Enzymatic degradation of proteoglycans is increased