Following change occurs in pregnancy :
Ans. is d i.e. Fibrinogen level increases Lets see each option separately : Option -a" Plasmin activity decreases : it is incorrect as COGDT clearly says : "Plasminogen levels increase Concomitantly with fibrinogen levels, causing an equilibration of clotting and lytic activity." Option "b" Fibrinolytic activity decreases : This is still a debatable issue studies are going on, Williams says? "Studies of the fibrinolytic system in pregnancy have produced conflicting results, although the majority of evidence suggests that fibrinolytic activityis actually reduced in normal preg? nancy." So option 'b' can be kept in +/- status, if we don't have a better option, it can be our answer of choice. Option "c" Hemodilution does not occur : "The dispropotionate increases in plasma and RBC volume produces a state of hemodilution during pregnancV" So, option "c is incorrect. As far as option `d' is concerned : We have studied time and again that fibrinogen level is raised by 50% in pregnancy. Therefore, option Tr is absolutely correct and is our answer of choice.
Plasmin level decreases
Fibrinolytic activity decreases
Hemodilution does not occur
Fibrinogen level increases