During sleep which hormone is increased?
Ans. D Ach* Awake state: Increase activity of norepinephrine- and serotonin-containing neurons (locus coeruleus and raphe nuclei) and reduced level of activity in acetylcholine- containing neurons (pontine reticular formation). Reduced GABA release and increase histamine release is also there.* REM state: Decrease activity of norepinephrine- and serotonin-containing neurons and increased level of acetylcholine containing neurons* NREM sleep: Increased release of GABA and reduced release of histamineExtra Mile *Serotonin: Old concept- necessary to obtain and maintain behavioral sleep (permissive role on sleep)* Serotonin: recent concept-suggests that during waking, serotonin may complement the action of nor-adrenaline and acetylcholine in promoting cortical responsiveness and participate to the inhibition of REM sleep effector neurons of the brainstem (inhibitory role on REM sleep)* Cortical Ach; Greatest during REM sleep > waking and reduced during non-REM (NREM) sleep.
Serotonin
Dopamine
GABA
Ach
Nervous System