True about polycystic ovarian syndrome
i.e. (Associated with carcinoma endometrium): (369-Shaw's 15th) (467-HI 7th)* The increased conversion of androstenedione to estrogen which occurs to a greater degree in women with lower body obesity may contribute to the increased incidence of uterine cancer in post menopausal women with obesity (467-H17th)* PCOS is most strongly associated with a risk of endometrial carcinoma and may also be associated with an increased risk of ovarian and breast cancer**** Long term sequelae of PCOS- Diabetes mellitus- CVS disorders - MI- Lipidaemia- Hypertension- Endometrial cancer- Breast cancer- Premature ovarian failure following surgery* Autosomal dominant inherited factor** were added as aetiological factor in the development of PCOS. CYP21 gene mutation has been discovered in this connection
Associated with carcinoma endometrium
Always associated with obesity
Diabetes incipidus
Hypo androgenemia
Miscellaneous (Gynae)