In a patient with breast cancer, the following are poor prognostic factors except
Prognostic factor of breastcarcinoma Age: Younger the age worser the prognosis. ( less than 35 years) Sex: Carcinoma male breast has got worser prognosis compared to female breast. Because of early spread in carcinoma male breast. Invasive carcinoma has got worser prognosis. Infl ammatory carcinoma breast has worst prognosis. ER +ve tumours has got better prognosis. Tumour grade, growth factor and oncogene factors. ErbB2--Her-2/Neu positive has got poor prognosis. ErbB1 with overexpression of epidermal growth factor (EGF), TGF alpha and cathepsin D has got poor prognosis. DNA flow aneuploid status has got poor prognosis. Low S phase fraction (< 5%) has got good prognosis. Ref; (page no; 559 ) 5th edition of SRB&;S manual of Surgery
High grade
Absence of estrogen receptor
Aneuploid status
Age less than 35 years
Endocrinology and breast