A genetic disorder renders fructose 1,6 bisphosphatase in liver less sensitive to regulation by fructose 2,6- bisphosphate. All of the following metabolic changes occur EXCEPT:
Note that question is asking about the wrong statement. as shown in flow cha below, The level of fructose 1,6 bisphosphate is lower than normal not higher in case of mutation. so option a is wrong. Explanation: Normally Fructose 2, 6 bisphosphate is the inhibitor of Fructose 1,6 bisphosphatase (an enzyme of gluconeogenesis). So, it decreases the activity of Fructose 1,6 bisphosphatase. Thus increases the rate of glycolysis. BUT now due to mutation, activity of Fructose 1,6 bisphosphatase is not decreased. So, Fructose 1,6 bisphosphatase will increase. So its substrate (Fructose 1, 6 bisphosphate ) is decreased. This is committed molecule of glycolysis. So glycolysis decreases. Therefore, ATP & Pyruvate decreases.
Level of fructose 1,6 bisphosphate is higher than normal
Level of fructose 1,6 bisphosphate is lower than normal
Less Pyruvate formed
Less ATP formed
Glycolysis