Chloroquine is a weak base that neutralizes acidic organelles. In a pancreatic beta cell, which of the following would be a direct effect of chloroquine treatment?
Increased proinsulin content in secretory vesicles * Chloroquine neutralizes acidic compaments such as the sectetory vesicles. * Chloroquine treatment inhibits the conversion of proinsulin to insulin, resulting in decreased formation of insulin within secretory vesicles. * Acidification causes concentration of the contents of secretory vesicles, facilitates breakdown of the contents of phagosomes and lysosomes, and is involved in the cleavage of prohormones to their active forms (e.g., proinsulin to insulin).
Increase proinsulin content in secretory vesicles
Increased release of C peptide
Increased number of amylase-containing secretory vesicles
Reduced translation of glucagon mRNA