Zidovudine causes:
Nucleoside reverse transcriptase inhibitors (Nis) Zidovudine :It is a thymidine analogue (azidothymidine, AZT), the prototype NI. Adverse effects Toxicity is mainly due to paial inhibition of cellular DNA polymerase. Anaemia and neutropenia are the most impoant and dose-related adverse effects. Nausea, anorexia, abdominal pain, headache, insomnia and myalgia are common at the sta of therapy but diminish later. Myopathy, lactic acidosis, hepatomegaly, convulsions and encephalopathy are infrequent. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:770,771
Neurotoxicity
Nephrotoxicity
Neutropenia
Ototoxicity
Chemotherapy