Allopurinol is used in organ preservation as:
Ans is c i.e. Free radical scavenger Organ preservation is the supply line for organ transplantation. Currently, the liver, pancreas, and kidney can be successfully preserved for up to two days by flushing the organs with the University of Wisconsin (UW) solution and storing them at hypothermia (0-5deg C). The UW solution is effective because it uses a number of cell impermeant agents (lactobionic acid, raffinose, hydroxyethyl starch) that prevent the cells from swelling during cold ischemic storage. Additionally, the UW solution contains glutathione, allopurinol and adenosine, agents that may stimulate recovery of normal metabolism upon reperfusion by augmenting the antioxidant capacity of the organs (glutathione) or by stimulating high-energy phosphate generation (adenosine) upon reperfusion and allopurinol as free-radical scavenger. Glutathione as antioxidant Adenosine as precursor for energy metabolism Allopurinol as free-radical scavenger
Antioxidant
Preservative
Free radical scavenger
Precursor for energy metabolism