Low doses of aspirin therapy is essentially advised for all of the following conditions except:
Answer is A (SLE) Low dose aspirin therapy has definite indication in preecclampsia, IUGR and post MI. There appears no rationale of using low dose aspirin for manifestation of SLE. Neveheless low dose aspirin is of definite benefit in antiphospholipid antibody syndrome. SLE is thus the single best answer of exclusion here. Low dose aspirin therapy markedly decreases thromboxane production but only paially blocks prostocyclin and prostaglandin E2 production. Pre-ecalmpsia: In preeclamptic woman, thromboxane is increased and prostaglandin E2 and prostacyclin are decreased, resulting in vasoconstriction and sensitivity to infused angiotensin II. Low dose aspirin as explained above enhances concentration of vasodilating prostanoids and restores refractoriness to infused angitensin II. Post MI: No confusions on this one. Low dose aspirin is advised to such patients. IUGR: Early antiplatelet therapy with low dose aspirin may prevent uteroplacental thrombosis, placental infarction, and idiopathic fetal growth retardation in women with a history of recurrent severe fetal growth restriction. -Williams 20`"/ 849 Fuher Williams 21st/1212 says: "Low dose aspirin & Dipyridamole are beneficial in reducing incidence of superimposed preeclampsia & growth restriction". SLE: Ahralgias, ahritis, myalgias, fever and, mild serositis may improve on NSAID's including salicyclates. However there appears no rationale of using low dose aspirin therapy for the same. (However low dose aspirin is beneficial in "Antiphospholipid antibody syndrome").
SLE
IUGR
Post myocardinal infarction
Pre ecclampsia