Histamine causes all EXCEPT:
Platelet aggregation REF: Robbin's pathology 7th edition page 63 Preformed histamine is present in mast cell granules and is released by mast cell degranulation in response to variety of stimuli. In humans histamine causes: Aeriolar dilatation Increased permeability of venules (however constricts large aeries) Via binding to H1 receptor on endothelial cells
Aeriolar dilatation
Increased permeability of venules
Constriction of large aeries
Platelet aggregation