Which of the following statement regarding cell ageing is TRUE?
Lipofuscin is a complex pigment that is thought to result from end stage lipid peroxidation probably by the oxidation of fat with free radical reactants. Its exact composition varies from cell to cell. It appears to accumulate in cells with highest metabolic activity. It is associated with atrophy of an organ. Lipofuscin is a mixture of lipids and proteins containing a golden brown pigment called ceroid. It tends to accumulate by accretion of oxidized, cross linked proteins and is not digestible. It occurs mainly in terminally differentiated cells (neurons and cardiac myocytes) or in cells that cycles infrequently(hepatocytes). Ref: Physiology Secrets edited by Hershel Raff page 317
Free radicals injury
Mitochondria are increased
Lipofuscin accumulation in the cell
Size of cell increased