Maximum histamine is released by ?
Ans. is 'a' i.e., d Tubocurarine Impoant facts about muscle relaxants (from Goodman & Gilman) Longest acting Neuromuscular blocker Pancuronium (duration of action 120-180 minutes). Note - KDT has mentioned doxacurium as longest acting. Shoest and fastest acting neuromuscular blocker Succinylcholine (suxamethonium) - duration of action 5-8 minutes. Shoest acting competitive (nondepolarizing) neuromuscular blocker Mivacurium (duration of action 12-18 minutes). Fastest acting nondepolarizing blocker Rocuronium (can be used for endotracheal intubation as an alternative to Sch). Histamine release is caused by --> D-TC (maximum tendency), succinylcholine, mivacurium, doxacurium, atracurium, tubocurarine can cause bronchoconstriction. Viually no histamine release.---- Pancuronium Maximal vagal block and tachycardia is caused by -9 Pancuronium (Previously it was gallamine, but it is not used now). Vagal stimulation is caused by --) succinylcholine. Maximum ganglion blockade is caused by d-TC Ganglion stimulation is caused by Succinylcholine Most commonly used muscle relaxant for routine surgery -9 vecuronium. Most potent skeletal muscle relaxant --> Doxacurium. oelaxa Least potent skeletal muscle relaxant Succinylcholine (Gallamine was least potent but it is not used now). Least potent nondepolarizing muscle rnt --> Rocuronium.
dTubocurarine
Succinylcholine
Pancronium
Gallamine