The peripheral smear of Hereditiary spherocytosis will show spherocytes -
Various mutations involving membrane skeletal proteins weakens interactions b/w proteins and cause red cells to lose memb fragments . This causes decrease in size of the spherocytes compared to normal RBCs Ref: Robins 9/e pg:632
Usually of same size as RBCs
Reticulocytosis absent
Anemia is negligible
Smaller size than RBCs
Haematology