A highly ionized drug
Ionized molecules cannot cross the biological membranes .therfore they are less likely to be absorbed . Entry of the molecules through blood brain barrier and blood placental barrier is also restricted .these drugs cannot be reabsorbed in the nephron,thus are excreted by the kidney . Refer kDT 7/e p29
Is excreted mainly by kidney
Can carry placental barrier easily
Is well absorbed from intestine
Accumulates in cellular lipids
General anatomy