A patient is a known case of polyarteritis nodosa. On examination of biopsy, accumulation of amorphous, basic, proteinaceous material in the vessel wall was seen. This finding is suggestive of:
Ans. (a) Fibrinoid necrosisFibrinoid necrosis is a form of necrosis, or tissue death, in which there is accumulation of amorphous, basic, proteinaceous material in the tissue matrix with a staining pattern reminiscent of fibrin.How to differentiate from hyaline arteriosclerosis?- please remember in fibrinoid necrosis, pink material has fibrin like quality as opposed to glassy homogenous hyaline in hyaline arteriosclerosis, (refer to image 2)
Fibrinoid necrosis
Leucocytoclastic vasculitis
Hyaline arteriosclerosis
Caseous necrosis
C.V.S