All are true regarding chloroquine, EXCEPT :
Ans. is 'a' acts only on exoerythrocytic cycle.]Reference KDT 5th p. 739 (4th page 793)]Chloroquine is a rapidly acting erythrocytic schizonticide. It is active against all species of plasmodium.It has no effect on pre and exoerythrocytic phase of the parasite.Mechanism of action of chloroquine :|First chloroquine is concentrated inside infected erythrocytes. (Higher cone in infected RBC).|Prevents the polymerization of heme into hemozoin|Heme damages the plasmodium membrane.About choice "B" K.D.T. says -" The earlier hypothesis that chloroquine acts by interfering with DNA function is now considered untenable"
Acts only on exo erythrocytic cycle
Acts on DNA and RNA of parasite
Causes pigmentation of nail and mucosa
Infected RBC has more drug