A 30-year-old came with complaints of thyroid swelling. On investigations her TSH levels were found to be elevated. Post operative histopathological examination repos shower lymphocytic infiltration and Huhle cells. Which of the following is the most likely diagnosis?
Hashimoto thyroiditis This autoimmune disorder occurs more often in women than in men. It is a common cause of hypothyroidism; may occasionally have anearly transient hypehyroid phase. Clinical characteristics include a slow, often inapparent course and a modestly enlarged and nontender thyroid; the patient is most often euthyroid at first, but transient hypehyroidism may occur; hypothyroidism develops latewhen the gland is shrunken and scarred. Histologic characteristics includemassive infiltrates of lymphocyteswithgerminal center formation; thyroid follicles are atrophic andHuhle cells(epithelial cells with eosinophilic granular cytoplasm) are prominent. Hashimoto thyroiditis is associated with various autoantibodies, most prominentlyantithyroglobulin, antithyroid peroxidase, anti-TSH receptor, and anti-iodine receptor antibodies. It may also be associated with an increased incidence of other autoimmune disorders such as pernicious anemia, diabetes mellitus, and Sjogren syndrome; incidence isincreased in HLA-DR5- and HLA-B5-positiveindividuals.
Graves disease
Follicular carcinoma
Hashimoto thyroiditis
Medullary carcinoma thyroid
NEET Jan 2020