Continuous GnRH is useful in all except:
Ans. (C) Male infertility(Ref: Goodman Gilman 13th E/P781)GnRH agonists can be used by pulsatile and non-pulsatile or continuous dosing.By pulsatile dosing they increase release of LH/FSH and cause ovulation, spermatogenesis and increase synthesis estrogen and testosterone. Hence used for treatment of anovulation, oligospermia (male infertility), delayed puberty and sexual infantilism.By continuous dosing, they decrease synthesis of estrogen and testosterone. Hence used for treatment of estrogen and testosterone dependent conditions like ER positive breast cancer, endometriosis, uterine fibroids and prostate cancer.
Precautious puberty
Prostate cancer
Male infertility
Endometriosis
Miscellaneous (Gynae)