Enzyme level increases in tissue injury is due to
In cell injury, there is increased membrane permeability leading to membrane damage. 1.Mitochondrial membrane damage-decreased ATP production 2.Plasma membrane damage- loss of osmotic balance and influx of ions and fluids. 3.Lysosomal membrane damage results in leakage of enzymes into the cytoplasm and activation of acid hydrolases in the acidic intracellular pH of the injured cell. Lysosomes contain RNases, DNases, proteases, glucosidases and other enzymes.Activation of these enzymes leads to enzymatic digestion of cell components. Refer robbins 9/e p39
Lysis of cell
Enzyme secretion
No inhibitor in serum
All of the above
General pathology