Pharmacokinetic characteristics of propranolol include Vd = 300 L/70 kg, C1 = 700 mL/min, and oral bioavailability f = 0.25. What is the dose needed to achieve a plasma level equivalent to a steady state level of 20 mg/L?
LD = 300L x 20 mg/L / 0.25 = 6000 mg/0.25 = 24,000 mg or 24 mg Ref:- kd tripathi; pg num:-33
4 mg
12 mg
24 mg
48 mg
General pharmacology