Which one of these drug causes QT prolongation in a premature baby?
Cisapride is a non-selective serotonin 5HT4 agonist and paial 5HT3 antagonist. This drug accelerates gastric emptying, so it is used in patients with Gastro Esophageal Reflex Disease (GERD). One of the rare complications includes QT prolongation in ECG, ventricular dysarhymias and sudden death. The drug has been withdrawn from most countries. Ref: Henry P. Parkman, Richard W. McCallum (2012) Chapter 22, "Prokinetic Agents for Gastroparesis", In the book, "Gastroparesis: Pathophysiology, Presentation and Treatment", Springer Publications, Newyork, Page 267 ; Katzung, 9th Edition, Page 1046
Cisapride
Metoclopramide
Omeprazole
Domperidone