All of the following changes are seen in dysplasia of squamocolumnar junction, except:
Ans. is a, i.e. Breaking of basement membraneRef: Robbin's 7th/ed, pl076, Shaw 15th/ed, p400Dysplasia: Represents a change in which there is alteration in cell morphology and disorderly arrangement of the cells of the stratified squamous epithelium. It is a premalignant lesion.Characteristics of Dysplastic cell:* Vary in sizeQ, shapeQ and polarityQ.* Have altered nucleo-cytoplasmic ratio (N/C ratio is increased).Q* Have large, irregular hyperchromatic nuclei with marginal condensation of chromatin material.Q* Have several mitotic figures.* The basement membrane, however, is intact and there is no stromal infiltration.
Breaking of basement membrane
Change of epithelium
Hyperchromatic nuclei
Increased mitotic figure
Carcinoma Cervix