Volume of distribution is NOT affected by all EXCEPT
(Binding to plasma protein) (31-33-KDT 6th)* The extent of distribution of drug depends on* Lipid solubility* Ionization at physiological pH (dependent on pKa)* The extent of binding to plasma and tissue proteins* Differences in regional bloodflow
Binding to plasma protein
Drug clearance
Lipid insolubility
Absence of blood brain barrier