Effect of Vmax and Km in competitive inhibition is as follows
In competitive inhibition, Drug binds to enzyme only .So, Velocity remains unchanged and Conc- km increases. In non- competitive inhibition, drug binds to enzyme substrate complex deceasing velocity unaffecting km. Ref: K.D.Tripati.7th ed. Pg 39
Km unchanged
Vmax increased, Km unchanged
Km increased, V max unchanged
Km and Vmax increased
General pharmacology