Before the onset of pubey, the GnRH neurons are under the inhibitory control of :
C i.e. Gamma amino butyric acidGn RH neurosecretion has been shown to be under the control of many neurotransmitter & neuropeptides:- GABA - exes an inhibitory action on GnRH secretion before onset of pubeyQ.- Glutamate - has an excitatory effectQ & whose levels increase at the onset of pubeyQ.Gama amino butyric acid (GABA)Q appears to be an inhibitory neurotransmitter responsible for restricting LHRH release before onset of pubey in female rhesus monkey.Recent studies suggest that during prepubeal period an inhibitory neuronal system suppresses LHRH release & that during the subsequent maturation of hypothalamus this prepubeal inhibition is removed allowing the adult pattern of pulsatile LHRH release. (Endocrine review by E. tersawa & D. Fernandez)
Glycine
Glutamate
Gamma amino butyric acid (GABA)
Beta-endorphin