A 15-year-old boy presented with 1 day history of bleeding gums, subconjunctival bleed and purpuric rash. Investigations revealed: Hb 6.4 gm/dL; TLC-26,500/mm3; prothrombin time-20 sec with a control of 13 sec; partial thromboplastin time-50 sec; and fibrinogen 10 mg/dL. Peripheral smear was suggestive of acute myeloblastic leukemia. Which of the following is the most likely?
c. Promyelocytic leukemia(Ref: Nelson's 20/e p 2442-2443, Ghai 8/e p 605-607)This patient has complaints of bleeding along with thrombocytopenia, decreased fibrinogen & increased PT & APTT. This is consistent with DIC; DIC is most commonly seen with M3 AML
Myeloblastic leukemia without maturation
Myeloblastic leukemia with maturation
Promyelocytic leukemia
Myelomonocytic leukemia
C.V.S.