A 37 year old male patient was diagnosed with sarcoidosis of lung and was kept on glucocoicoid therapy. The treatment may result in the bone loss because glucocoicoids causes which of the following?
Glucocoicoids increase bone resorption. They have multiple actions that alter bone metabolism.Glucocoicoids decrease intestinal Ca++ absorption and renal Ca++reabsorption. Both mechanisms serve to lower serum . As serum drops, secretion of parathyroid hormone PTH) increases, which mobilizes Ca++from bone by stimulating resorption of bone. Glucocoicoids also directly inhibit osteoblast bone-forming functions.Reference: Berne & Levy Medical Physiology; 6th edition; Page no: 749
Increases calcium absorption from the gastrointestinal tract
Increased osteoblast growth
Inhibit bone formation
Inhibit bone resorption
General physiology