HIV target binding site:-
Attachment of HIV with host cell is mediated by Gp120 and fusion of HIV to host cell takes place by fusion protein gp41. HIV first attaches to a CD4 cell. The proteins on the outer surface of HIV (called gp41 and gp120) connect with receptors on the surface of the CD4 cell (usually the CD4 receptor and the CCR5 coreceptor). Gp120 is an envelope glycoprotein that is exposed on the surface of the HIV virus. gp41 is a trans-membrane protein complex of HIV. HIV drugs that block this process are called entry inhibitors. This family of drugs block attachment to gp41 or gp120 on the CD4 receptor or block the coreceptor CCR5. Monoclonal antibodies(mAbs) can also block this stage. p24 is the surface protein used in the early diagnosis of HIV.
gp 120, gp 41
gp 120, p24
gp 120
p24, p40
Virology (RNA Virus Pa-1,2 & Miscellaneous Viruses)