In which of the following diseases decrease in levels of single neurotransmitter was first identified?
Neurons of the substantia nigra communicate with neurons of the basal ganglia by liberating the neurotransmitter dopamine (DA). In Parkinson's disease, neurons of the substantia nigra progressively degeneration; as a result, the amount of DA available for neurotransmission in the corpus striatum is lowered. Ref Harrison20th edition pg 2456
Alzheimer's disease
Parkinson's disease
Huntington disease
Schizophrenia
C.N.S