E6 gene product of HPV causes malignance transformation by acting on ?
Ans. is 'a' i.e., p-53 gene HPV selectively infects the epithelium of skin and mucous membrane and may immoalize the keratinocytes leading either asymptomatic infection, or was or neoplasia.Products of E-genes (E6, E7) are related to immoalization or malignant transformation of keratinocytes by interfering with p53 and Rb genes, respectively.
p53 gene
RAS gene
C-myc gene
N-myc gene