Which of the following change is observed following neonatal thymectomy?
T lymphocytes are selectively seeded into ceain sites in the peripheral lymphatic tissues, such as white pulp of the spleen, around the central aerioles and in the paracoical areas of lymph nodes. These regions have been termed as thymus dependent regions as they are depleted after neonatal thymectomy. Secondary to thymectomy, there is a reduction in the size of paracoical regions of the lymph node and periaeriolar tissue in the spleen. In the lymph node the thymus dependent paracoical areas shows depletion of lymphocytes, while there is a loss of lymphoid cells around the small blood vessels in the spleen. Ref: Nutrition, Immunity and Infections By Prakash S. Shetty, Page 44 ; Histology By Ray C. Henrikson, Volume 518, Page 220
Decrease in size of germinal center
Increased antibody production by B cells
Increased bone marrow production of lymphocytes
Decrease in size of paracoical areas of lymph nodes