All of the following statements about hybridoma technology are true except -
Myeloma cells lacks HGPRT enzyme, hence they cannot grow well in HAT medium.'
Ref: Apurba Sastry’s Essentials of Medical Microbiology p117
Specific antibody producing cells are integrated with myeloma cells
Myeloma cells with mutation salvage pathway grows well in HAT medium.
Aminopterin, a folate antagonist, inhibits denovo pathway
HGPRT ase and thymidylate synthetase are required for salvage pathway