All are true regarding oral hypoglycemic agent, EXCEPT :
Ans. is 'a' Effective only after total pancreatectomy Mechanism of action of sulfonylureasPresence of at least 30% functional pancreas is necessary for the action of oral hypoglycemics (Sulfonyl ureas).They act on sulfonylurea receptors present on beta cells of pancreas. This increase insulin secretion.Oral hypoglycemics are used only in uncomplicated type 11 diabetes (N1DDM).Both phenformin and metformin cause lactic acidosis (Phenformin > metformin).
Effective only after total pancreatectomy
Metformin causes lactic acidosis
Causes release of insulin from beta-cells
Useful in obese maturity onset diabetics
Anti Diabetes