Which one of the following drugs is most likely to block K+ channels in the heart responsible for the delayed rectifier current?
Amiodarone is a highly effective antiarrhythmic drug, in part because of its multiple actions, which include Na channel block, beta adrenoceptor block, K channel block, and Ca channel block. Drugs that block K channels (which include class IA and class III antiarrhythmics) prolong APD and ERP and predispose toward torsades de pointes ventricular arrhythmias. Encainide is a class IC drug, lidocaine and phenytoin are class IB, and verapamil is class IV, none of which inhibits the delayed rectifier K current responsible for membrane repolarization during the cardiac action potential.
Amiodarone
Encainide
Lidocaine
Phenytoin
C.V.S