A new born presented with bloated abdomen sholy after bih with passing of less meconium. A full-thickness biopsy of the rectum was carried out. Which one of the following rectal biopsy findings is most likely to be present?
Delayed passage of less meconium, together with abdominal distension after bih suggests the diagnosis of Hirschprung's disease. Confirmation of diagnosis is based on lack of ganglion cells (aganglionosis), in the myentric plexus together with hyperophic nerve fibres in the plexus. Ref: Bailey and Love's Sho Practice of Surgery, 24th Edition, Page 1154
Fibrosis of submucosa
Hyalinisation of the muscular coat
Thickened Muscularis propria
Lack of ganglion cells