A patient of prinzmetal's angina is started on isosorbide mononitrate. What is the mechanism of action of nitrates in this condition?
Ans. (D) Endothelium independent coronary vasodilation(Ref: KDT 7th/e p541)Predominant mechanism of action of nitrates in angina:*In Classical angina: Decrease in preload*In Variant angina: Coronary vasodilation
Reduced cardiac contractility
Increased left ventricular end diastolic volume
Decreased diastolic perfusion pressure
Endothelium independent coronary vasodilation
C.V.S