Best antihypeensive drug used in pulmonary hypeension is:
Ans: D. Bosentan(Ref Harrison 19/e p1659, 18/e p2079)Treatment of Pulmonary Aerial HypeensionEndothelin-Receptor AntagonistsBosentan & ambrisentan are approved for the treatments of Bosentan is contraindicated in patients who are on cyclosporine or glyburide concurrently.Phosphodiesterase-5 InhibitorsSildenafil and tadalafil are approved for the treatment of PAHMC side effect is headacheNeither drug should be given to patients who are taking nitro vasodilators.ProstacyclinsIloprost is approved inhalation for PAHdeg.Epoprostenol is approved as a chronic IV treatment of PAH.Treprostinil, an analogue of epoprostenol, is approved for PAH and may be given intravenously, subcutaneously, or inhalation.The intravenous prostacyclins have the greatest efficacy as treatments for PAH and are often effective in patients who have failed all other treatments.Lung TransplantationLung transplantation is considered for patients who, while on an intravenous prostacyclin, continue to manifest right hea failure.
Digoxin
Furosemide
Amlodipine
Bosentan