All of the following cause intravascular hemolysis, Except:
Answer is C (Thalassemia) Hemoglobinopathies including thalassemia cause extravascular hemolysis and not intravascular hemolysis. Causes of intravascular hemolysis Blood transfusion - ABO mismatched transfusion - Infected blood Thermal burns Snake bites Sepsis - Bacterial / parasitic infections - Clostridial sepsis - Malaria - Baonellosis - Mycoplasma pneumoniae Mechanical hea valves Paroxysmal hemoglobinuria - PNH - PCH Causes of extravascular hemolysis Blood and viral infections - Malaria - Mycoplasma pneumoiae - Infectious mononucleosis Drug-induced hemolysis - G6PD/GSH deficiency - Autoimmune drug reactions - Strong oxidant drugs/chemicals Autoimmune hemolysis - Warm-reacting (IgG) AIHA - Cold-reacting (IgM) AIHA Hemoglobinopathies - Thalassemia Membrane structural defect - Hereditary sperocytosis - Hereditary spherocytosis - Acanthocytosis Environmental disorders - Malignancy/D1C - TTP/HUS
Mismatched Blood transfusion
Snake bite
Thalassemia
Paroxysmal Nocturnal Hemoglobinuria (PNH)