Which of the following condition is associated with increase in LDH levels?
LDH is used in assessment of tissue breakdown in general or hemolysis. It is used to follow-up cancer (especially lymphoma) patients, as cancer cells have a high rate of turnover with destroyed cells leading to an elevated LDH activity. Here all given options are malignancies. But the term 'bulky disease' indicates increased disease burden than others. So that is the answer. LDH levels are raised in: Testicular carcinoma Hemolytic anemia Visceral infarction Lymphoma, Leukemia Pleural effusions and serositis Melanoma Interstitial lung diseases Myopathies Meningitis and encephalitis HIV Dysgerminoma Increased tissue turnover
Bulky disease
Lymphoma
Liver metastasis
Lung metastasis