Lack of leucocyte adhesion molecules (LAM) is associated with:
a. Delayed fall of umbilical cord(Ref: Nelson's 20/e p 1027, Ghai 8/e p 187)Leukocyte adhesion deficiency (LAD)Salient featuresLAD type 1LAD type 2InheritanceAutosomal recessiveAutosomal recessiveBasic defectDefect in CD 18 moleculeQ required for biosynthesis of B2 chain shared by LFA-1 & Mac-1 integrinsAbsence of Sialyl-Lewis X, the fucose-containing ligand for P & E-selection, due to defect in fucosyl-transferase responsible for binding fucose moieties to protein backbonesClinical featuresRecurrent bacterial infections, delayed separation of umbilical cord stumpQRecurrent bacterial infections, Bombay blood groupQ and mental retardation
Delayed fall of umbilical cord
Normal chemotaxis
Complement opsonization
Neutropenia
New Born Infants