Which of the following determines the speed of recovery from IV anesthetic?
Ans. c. Redistribution of the drug from sites in the CNSAn IV anesthetic completely bypasses the process of absorption, because the drug is placed directly into the bloodstream. Highly perfused organs (vessel rich) including the brain take up disproportionately large amount of drug compared to less perfused areas (the muscle, fat, and vessel-poor groups).Drugs bound to plasma proteins are unavailable for uptake by an organ.After the highly perfused organs are saturated during initial distribution, the greater mass of the less perfused organs continue to take up drug from the bloodstream.As plasma concentration falls, some drug leaves the highly perfused organs to maintain equilibrium.This redistribution from the vessel-rich group is responsible for termination of effect of many anesthetic drugs.
Liver metabolism of drug
Protein binding of drug
Redistribution of the drug from sites in the CNS
Plasma clearance of the drug
General Anesthesia