Which of the followng parameters is not monitored in a patient on methotrexate therapy?
Ans. is 'c' i.e., Eye examination If you know the adverse effects of methotrexate, you can easily understand the investigations which are required in patients taking methotrexate. Adverse effects of methotrexate o Hematological toxicity: Myelosuppression, megaloblastic anemia and pancytopenia. So, hemogram is required. Organ toxicity: Nephrotoxicity (renal function test), Liver toxicity (Liver function test), Pulmonary toxicity (Pulmonary function test) and Neurotoxicity (with intrathecal administration). Nodulosis, oral ulceration, GI upsets, and photosensitivity.
Liver function tests
Lung function test
Eye examination
Hemogram