MELAS inhibit all ETC Complexes EXCEPT:
MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke) MELAS inhibits complex I, III & IV of ETC. It is an inherited condition due to NADH-Q oxidoreductase, Caused by a mutation in mitochondrial DNA Involved in Alzheimer disease and diabetes mellitus. ETC is affected, brain is affected and due to anaerobic metabolism, lactic acidosis occurs.
I
II
III
IV
ETC