Mechanism of action of ciprofloxacin in gram negative bacteria:-
MECHANISM OF FLUOROQUINOLONES (FQ) In gram negative bacteria, FQ inhibit DNA gyrase by binding to its A subunit and interfere with cutting and resealing function. In gram positive bacteria, FQ inhibit similar enzyme DNA topoisomerase IV.
Inhibition of mycolic acid
Inhibition of topoisomerase IV
Inhibition of DNA gyrase
Inhibition of helicase
Antimetabolites and Quinolones