Which teratogen causes deafness Imatinib is used in the treatment of ?
Isotretinoin Isotretinoin can cause nzicrotia or anotia. These defects are frequency associated with agenesis or stenosis of the external ear canal and may lead to deafness. According to international journal of pediatrics otorhinolaryttgology "Despite extensive precautions for its use, isotretinoin remains a cause of major bih defects including sensorieneural, conductive or mixed hearing loss". Isotretinoin is one of the most potent teratogene in common use. Abnormalities commonly occur after 1st trimester. Any organ system can be affected by isotretinoin exposure but malformations typically involve the cranium, face, hea, central nervous system and thymus. Facial defects include cleft palate and maldevelopment of the facial bones and cranium. Cardiac anomalies include conotruncal or outflow tract defects. Hydrocephalus is the most common central nervous defect. Thymic abnormalities include aplasia, hypoplasia or malposition. Features of Fetal Alcohol syndrome Behaviour disturbances Brain defects Cardiac defects Spinal defects Craniofacial anomalies - Absent or h)poplastic philtrum - Broad upper lip - Flattened nasal bridge - Hypoplastic upper lip vermilion - Micrognathia - Microphthalmia - Sho nose - Sho palpebral tissues Warfarin First trimester - Hypoplastic nasal bridge, chondrodysplasia Second trimester - C.N.S. malformation Third trimester - Risk of bleeding, Discontinue the use one month before delivery
Chronic myelomonocytic leukemia
MDS
ALL
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