Most common mitochondrial enzyme for metabolism detoxification reaction is -
Ans. is 'a' i.e., CYP 3A4 Subtypes of cytochrome P-450o Depending upon the extent of amino acid sequence homology, the cytochrome PASO (CYP) isoenzymes are grouped into families designated by capital letters (A, B, C....).o Individual isoenzymes are again alloted numerals (1, 2, 3 ....).o Examples are CYP1A2, 2A6, 2B6, 2C8, 3A4/3A5.o In human beings, only a few members of three isoenzyme families carry out metabolism of most of the drugs,o Cyp 3 A 4/5 carryout biotransformation of largest number (nearly 50%) of drugs.Important inducers of CYP 3A4/3A5o Barbiturateso Carbamazepineo Glucocorticoidso Phenytoino Rifampino Pioglitazoneo Macro)ide antibiotics
CYP 3A4
CYP 1A2
CYP 2A6
CYP 2B6
Pharmacokinetics