Fifth clinical sign i.e., loss of function (functio laesa) was added by:
Acute inflammation Four cardinal signs of inflammation was given by Celsus. Rubor (redness) Tumor (swelling) Calor (heat) Dolor (pain). These signs are hallmarks of acute inflammation. A fifth clinical sign, loss of function (functio laesa), was added by Rudolf Virchow in the 19th century. Metchinkoff described process of phagocytosis.
Rudolf Virchow
Elie Metchinkoff
Louis Pasteur
George Bernard
Basic Concepts and Vascular changes of Acute Inflammation