Prolonged prothrombin time is seen in ?
Prothrombin time evaluates extrinsic factors and common pathway factors (factors 1,2,5,7,10).Prolongation of PT time occurs with deficiency of these factors. Haemophilia A is due to factor 8 deficiency, which is an intrinsic factor.So no PT prolongation Haemophilia B due to factor 9 deficiency. No PT Prolongation Thrombocytopenia due to decreased platelet number. so no PT prolongation . Factor 7 is an extrinsic factor .So its deficiency causes prolongation of PT Ref. Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no.657,662,663 Harsh Mohan textbook of pathology 7th edition.Pg no.307
Haemophilia A
Haemophilia B
Thrombocytopenia
Factor VII deficiency
Haematology