Glyceryl trinitrate is given by sublingual route because of:
Ans. (B) High hepatic first pass metabolism(Ref: KDT 8th/e p588)Main advantage of sublingual route of drug administration is that liver is bypassed and drugs with high first pass metabolism are absorbed directly into systemic circulation.
Short t1/2 in plasma
High hepatic first pass metabolism
High bioavailability by oral route
Extensive protein binding
C.V.S