True about hCG
Ans: B (Prevent involution of corpus luteum) hCG is produced by the syncytiotrophoblast of the placenta. Its value reach maximum levels ranging 100 IU & 200 IU/ml b/w 60-70 days of pregnancyIt can be detected in the material serum or urine as early as 8-9 days following ovulation.The rescued maintenance of corpus luteum till 6 wk of pregnancy is the major biological function ofhCG7- Dutta obstetrics 6th/ 58"It can be measured by radioimmunoassay & detected in blood as early as 6 days after conception0"- Ganong22th/449Human Chorionic Gonadotropin (hCG) - Dutta 6th/ 58, 186. 207# High level of hCG could be detected in - mu Itiple pregn ancy hydatiform mole or choriocarcinoma' & relatively high in pregnancy with a 21 - trisomy fetus (Dawn's syndrome }# Estimation of bhCG by ELISA is positive in 95% of ectopic pregnancies, A single estimation of bhCG level either in serum or in urine confirms pregnancy but cannot determine its location. The suspicions findings are lower concentration of bhCG compared to normal intra-uterine pregnancy & doubling time3 in plasma fails to occur in 2 days.Maternal serum chorionic gonadotropin is approximately doublet in twins than those of singleton pregnancies. But their values cannot diagnose clearly a twin from a single fetus.hCG : Review of facts# It is a glycoprotein 1 consisting of a hormone non-specific & a hormone specific b subunit.# hCG is chemically & functionally similar to pituitary luteinising hormone'3. The a subunit is biochemically similar to LH, FSH & TSH where as the P subunit is relatively unique to hCG.# It is produced by the syncytiotrophoblast of the placenta and secreted into the blood of both mother & fetus# Half life of hCG is about 24 hours# By radioimmunoassay it can be detected in the maternal serum or urine as early as 8-9 days'3 following ovulation. In early pregnancy, the doubling time of hCG concentrations is plasma is 1.4-2 days1'. The blood & urine values reach maximum levels ranging 100 IU & 200 IU/ml b/w 60-70 days of pregnancy# It is commercially obtained from the urine of pregnant women- Shows Gynaecology 14th/ 137# The rescue & maintaince of corpus luteum till 67 weeks of pregnancy is the major biological function of hCG.
Produced by cytotrophoblast
Prevent involution of corpus iuteum
Value reach maximum level at 20 wk of pregnancy
Its secretion starts after 2 day of ovulation
Endocrine Control of the Menstrual Cycle