Causes for less bioavailability -
Ans. is 'a' i.e., High first pass metabolism o Causes for less bioavailability. Incomplete absorption o High first pass metabolism. About other options Increased absorption increases bioavailability. o I.V. administration has 100% bioavailahi I ity. High lipid solubility causes more absorption and better bioavailability.
High first pass metabolism
Increased absorption
IV drug administration
High solubility