True about pioglitazone are all except:
Pioglitazone cause activation of genes regulating fatty acid metabolism and lipogenesis in adipose tissue contributes to the insulin sensitizing action. (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 270)
Metabolized in the liver by CYP3A4
Selective agonist for the nuclear peroxisome profilerator activated receptor gamma
It causes transcription of gene for carbohydrate and fat metabolism in the absence of insulin
It should be avoided in a patient with cardio-vascular disease
Endocrinology