Which is activated for nuclear fragmentation in apoptosis -
Caspases and endonuclease cause chromatin fragmentation in apoptosis. They are inactive, so first they should be activated. Cytochrome &;c&; binds with Apaf-1 and this complex activates caspases. Caspases cause fragmentation of chromatin and also activate endonuclease. About option &;b&; Though Apaf-1 helps in activation of caspases, it has no role in chromatin framentation and It does not have two seprate forms active or inactive. It just forms complex with cytochrome &;C&; to activate caspases. REF: ROBBINS pathology 10th edition
Caspases
Apaf - 1
Oxygen free radicals
All
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