Irreversible injury in myocardium occurs at
Only severe ischemia lasting at least 20 to 40 minutes causes irreversible damage and myocyte death leading to coagulation necrosis. Withlonger periods of ischemia, vessel injury ensues, leading to microvascular thrombosis.( Robbins Basic Pathology, 9th edition, page 377 )
2 minutes
30 minutes
2 hours
5 hours
General pathology