All of the following are true regarding Kaposi sarcoma except:
Kaposi's sarcoma is a malignant, proliferative tumour of vascular endothelial cells, now most commonly associated with immune compromise after transplantation or HIV infection . There appears to be a causal link with infection by human herpes virus 8. Kaposi's sarcoma usually stas as a red brown, indurated, plaque-like, skin lesion that becomes nodular and then ulcerates. KAPOSI SARCOMA Kaposi's sarcoma appears as rubbery bluish nodules that occur primarily on the extremitiesQbut may appear anywhere on the skin and visceraQ. Classically, KS is seen in people of Eastern Europe or sub-Saharan AfricaQ. AIDS RELATED KAPOSI SARCOMA AIDS-related KS occurs primarily in male homosexuals and not in IV drug abusers or hemophiliacsQ Lesions spread rapidly to the nodes and GI and respiratory tract often are involvedQ. Development of AIDS-related KS is associated with concurrent infection with a herpes-like virus (HHV-8) PATHOLOGY Usually multifocalQrather than metastatic. Histologically, the lesions are composed of capillaries lined by atypical endothelial cellsQ. Early lesions may resemble hemangiomas, while older lesions contain more spindle cells and resemble sarcomas. Lesions are locally aggressive but undergo periods of remissionQ. TREATMENT Treatment for all types of KS consists of radiationQto the lesions. Combination chemotherapy is effective in controlling the disease, although most patients develop an oppounistic infection during or sholy after treatmentQ. Surgical treatment is reserved for lesions that interfere with vital functions:, such as Bowel obstruction and Airway compromiseQ Most common malignancy in HIV positive individuals: NHL > Kaposi sarcomaQ
Predominant in male
Multicentric origin
Chemotherapy is treatment of choice
Occurs in AIDS patients only
Oncology