Which of the following organism plays an impoant role in pathogenesis of 'malt worker's lung'?
Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is an inflammatory disorder of the lung involving alveolar walls and terminal airways that is induced by repeated inhalation of a variety of organic agents in a susceptible host. Malt worker's lung is caused by Aspergillus fumigatus or A. clavatus and source of antigen is moldy barley. Examples of Hypersensitivity Pneumonitis (HP): Disease Antigen Source of Antigen Bagassosis & Farmer's lung Thermophilic actinomycetes "Moldy" bagasse (sugar cane), hay, grain, silage Bird fancier's, breeder's, or handler's lung Parakeet, pigeon, chicken, turkey proteins An droppings or feathers Compost lung Aspergillus Compost Humidifier or air conditioner lung (ventilation pneumonitis) Aureobasidium pullulans, Candida albicans, Thermophilic actinomycetes, mycobacterium spp., other microorganisms Contaminated water in humidification or forced-air air conditioning systems Miller's lung Sitophilus granarius (wheat weevil) Infested wheat flour Mushroom worker's lung Thermophilic actinomycetes, Hypsizygus marmoreus, Bunashimeji, and other exotic mushrooms Mushroom compost; mushrooms Potato riddler's lung Thermophilic actinomycetes, Aspergillus "Moldy" hay around potatoes Sausage worker's lung Penicillium nalgiovense Dry sausage mold Tap water lung Mycobacteria spp. Contaminated tap water Tobacco worker's disease Aspergillus spp. Mold on tobacco Wine Grower's lung Botrytis cinerea Mold on grapes Wood trimmer's disease Rhizopus spp., Mucor spp. Contaminated wood trimmings Woodman's disease Penicillium spp. Oak and maple trees Woodworker's lung Wood dust, Alternaria Oak, cedar, pine, and mahogany dusts Ref: Gerke A.K., Hunninghake G.W. (2012). Chapter 255. Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.
Aspergillus clavatus
Aspergillus fumingatus
Pseudomonas
Micropolyspora faeni