A 50 year old male is taking medication for tuberculosis since the last 2 months comes to the OPD with a complaint of hearing problems. The drug with which of the following mechanisms of action is most likely causing these symptoms?
Streptomycin used in Tuberculosis produce ototoxicity. Aminoglycosides act by inhibiting protein synthesis after binding to the 30s ribosome and inhibiting 1st step - initiation complex formation.Ref: Katzung 13th ed Pg 799
Binds to 30S Ribosome subunit and inhibits initiation complex
Inhibits DNA Dependent RNA Polymerase
Inhibits synthesis of mycolic acid
Inhibits synthesis of arabinoglycan subunits
Respiratory system