True statement regarding development of drug resistance in MRSA is:
Ans. (B) Occurs due to change in penicillin-binding proteins(Ref: Katzung's 11/e p776, KDT 8/e p743)Methicillin resistance occurs due to altered PBPs, thus no penicillin, (infact no beta-lactam antibiotic) is useful against methicillin-resistant Staphylococcus aureus (MRSA) infections.
Results due to penicillinase enzyme production
Occurs due to change in penicillin-binding proteins
Chromosome mediated
Treated with amoxicillin + clavulanic acid
Chemotherapy: General Principles