Immunoglobulin variation does not depend on -
Ans. is 'a' i.e., Light chain The isotype variation or class of antibody is due to variation in the amino acid sequence in the constant region of the heavy chain.Because there are five potential variation in the aminoacid sequence in the constant region there are five classes of antibody i.e. IgG, IgM, IgA, IgD, IgE.
Light chain
Heavy chain
Amino acid sequence
Constant region