Changes in which amyloid structure makes it insoluble?
Ans. is 'b' i.e., Secondary * Amyloid is a protein that has an alteration in its secondary structure which imparts it a particular insoluble form, called the beta-pleated sheet conformation.* Amyloid material is composed of two components -i) Major component (95%) - Fibril amyloid protein.ii) Minor components (5%) - P-component, proteoglycans and sulfated glycosaminoglycans.* Fibril amyloid protein is responsible for tissue dysfunction due to pressure effect, while Pcomponent contributes to amyloid deposition by stabilizing fibril amyloid protein and decreasing their clearance.
Primary
Secondary
Tertiary
Quaternary
Immunity