A 15-year-old boy is bitten by an Ixodes tick while camping with his parents and presents 1 week later with fatigue, fever, headache, and a reddish rash over his trunk and extremities. Positive IgM antibody (1 :200) to Borrelia burgdorferi is associated with which of the following?
Borrelia burgdorferi, the causative agent of Lyme disease, elicits an acute antibody response. IgM appears within days to a few weeks following tick bite, and IgG appears a few weeks later. IgG persists; IgM does not. Cross-reactions occur with other treponemes.
Acute Lyme disease
Fifth disease
Possible hepatitis B infection
Possible subacute sclerosing panencephalitis (SSPE)
Immunology