Increased formation of ketone bodies during fasting is a result of which of the following?
During a fast, catabolism is increased to provide additional sources of energy. This is characterized by increased utilization of fatty acids. When the production of acetyl CoA (produced by enhanced β-oxidation) exceeds the oxidative capacity of the citric acid cycle, ketone bodies are formed. During fasting conditions, glucagon concentrations are increased and glycogenesis is inhibited due to limited energy availability. Acetyl CoA production in the liver is increased due to enhanced β-oxidation.
Increased oxidation of fatty acids as a source of fuel
Decreased formation of acetyl CoA in the liver
Decreased levels of glucagon
Increased glycogenesis in muscle