A 56-year-old man is surgically treated by a four-vessel coronary aery bypass graft procedure and placed on prophylactic daily aspirin therapy. Aspirin has been shown to prevent recurrent myocardial infarction through its ability to inhibit the synthesis of
Aspirin Irreversibly inhibits the enzymes cyclooxygenase 1 and 2 Inhibits synthesis of Thromboxane A2 (TxA2). TxA2 promotes platelet aggregation,as does ADP. Aspirin inhibits platelet aggregation, which is an impoant early step in atherogenesis.
Adenosine diphosphate (ADP).
Leukotriene B4 (LTB4 )
Nitric oxide (NO).
Thromboxane A2 (TXA2)
Platelet