A 19-year-old male complains of Shoness of breath associated with wheezing after he takes aspirin for headache. In cases of aspirin hypersensitivity, which of the following mediators will be responsible for above mentioned condition?
Aspirin act by inhibiting PG synthesis by cyclo-oxygenase pathway, so PG precursors are diveed to form leukotrienes in the lipoxygenase pathway. In patients having aspirin hypersensitivity, this leads to bronchoconstriction and shoness of breath.
Leukotriene LTC4
PGE2
Prostacyclin
Thromboxane
Histamine, 5-HT and PGs