A highly ionized drug:
Ans. (A) Is excreted mainly by the kidneys(Ref: KDT 8th/e p36)Ionized molecules cannot cross the biological membranes. Therefore, these are less likely to be absorbed. Entry of these molecules through blood brain barrier and blood placental barrier is also restricted. These drugs cannot be reabsorbed in the nephron, thus are excreted by the kidneys.
Is excreted mainly by the kidney
Can cross the placental barrier easily
Is well absorbed from the intestine
Accumulates in the cellular lipids
General Pharmacology