Not true about Fosphenytoin
Fosphenytoin, a more soluble phosphate prodrug of phenytoin, is well absorbed. Fosphenytoin sodium is available for intravenous or intramuscular use and replaces intravenous phenytoin sodium, a much less soluble form of the drug. Used in generalized Tonic-clonic seizures and paial seizures. Highly bound to plasma proteins.Reference: Katzung Pharmacology; 13th edition; Chapter 24; Antiseizure Drugs
Used for GTCS
Prodrug of Phenytoin
Lipid soluble
Highly protein bound
Central Nervous system