Nitric Oxide Synthase
Nitric oxide is formed from arginine by the enzyme nitric-oxide synthase (NOS).It contains heme, FAD, FMN and tetrahydrobiopterin. The enzyme utilizes NADPH and molecular oxygen. Calmodulin is required to modulate its activity.The guanidino nitrogen of arginine is incorporated into NO.. From the molecular oxygen, one atom is added to NO. and the other into citrulline. Therefore, the enzyme is a di-oxygenase Ref: D M Vasudevan 7th edition Page no: 228
Is inhibited by Ca++
Catalyzes a dioxygenase reaction
Accepts electrons from NADH
Requires NADH, FAD, FMN & Heme iron
miscellaneous