Transition from G2 to M phase of the cell cycle is controlled by -
o Resting cells are in G0 phase of cell cycle and need to be recruited into the G, stage and beyond in order to replicate. The entry and progression of cells through the cell cycle is controlled by changes in levels and activities of cyclins and cyclin dependent kinases (CDKs), and their inhibitors.
Retinoblastoma gene product
p53 protein
Cyclin E
Cyclin B