Which of the following is not a major criteria for diagnosis of multiple myeloma?
"Lytic bone lesions" is not a major criteria for the diagnosis of multiple myeloma. It is a minor criteria for the diagnosis of multiple myeloma. So "Lytic bone lesions" is the single best answer of choice. Ref: The Washingtom Manual of Surgical Pathology: Depament of Pathology By Peter A Humphrey, Loius P.Dehner, Ohn D. Pfeifer, Page 565.
Lytic bone lesions
Plasmacytoma on tissue biopsy
Bone marrow plasmacytosis > 30%
M' spike > 3g% for Ig G, > 2g% for IgA