About first order kinetics,true statement is
Clearance is variable in zero-order kinetics because a constant amount of the drug is eliminated per unit time, but it is constant in first-order kinetics, because the amount of drug eliminated per unit time changes with the concentration of drug in the blood Ref-KDT 6/e p32
Clearance remains constant
Fixed amount of drug is eliminated
Half life increases with dose
Decreases clearance with increased dose
General anatomy