Peripheral necrosis of liver is caused by
Hepatocellular damageExamplesMicrovascular fatty changeTetracycline, salicylates, yellow phosphorus, ethanolMacrovascular fatty change Ethanol, methotrexate, amiodaroneCentrilobular necrosisBromobenzene , CCL4,acetaminophen,halothane ,rifampinDiffuse or massive necrosisHalothane, isoniazid, acetaminophen, methyldopa, trinitrotoluene, Amanita phalloides toxinHepatitis Methyldopa, isoniazid, nitrofurantoin, phenytoin, oxyphenisatinFibrosis-cirrhosis Ethanol, methotrexate, amiodarone, most drugs that cause chronic hepatitisGranuloma formation Sulfonamides, methyldopa, quinidine, phenylbutazone, hydralazine, allopurinolCholestasis Chlorpromazine, anabolic steroids, erythromycin, estolate, OCP, organic arsenicalsPeripheral necrosisPhosphorus (Refer: Robbins & Cotran's - Pathologic Basis of Disease, SAE, 1st edition, Vol II-pg no: 840 &841)
Carbon tetrachloride
Benzene
Phosphorus
Rifampicin
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