Arrange the incidence of various types of breast cancers in increasing incidence. a. PTEN ( Cowden disease )b. Sporadic breast cancerc. Hereditary breast cancerd. BRCA1e. BRCA2f. Familial breast cancer
Breast cancer Incidence Sporadic breast cancer 65-75 % Familial breast cancer 20-30 % Hereditary breast cancer 5-10 % BRCA1 45 % BRCA 2 35 % p53 ( Li-Fraumeni syndrome ) 1 % STK11/LKB1a (Peutz-Jegherssyndrome), PTENa (Cowdendisease), MSH2/MLH1a ( Muir-Torresyndrome), ATMa (Ataxiatelangiectasia ) Less than 1 % Unknown 20 %
a,b,c,d,e,f
a,d,b,c,f,e
c,a,f,d,b,e
a,c,f,e,d,b
Breast