Which of the following opioid should not be used with MAO inhibitors?
Ref: KD Tripathi 6/e p440 Most of Pethidine is metabolized by MAO-A and is inactivated. Small amount is conveed to nor-Pethidine, which has CNS stimulant propeies. Therefore if combined with MAO inhibitors, most of Pethidine will form nor-Pethidine and the risk of seizures will increase.
Morphine
Pentazocine
Buprenorphine
Pethidine
Central Nervous system