Which of the following drug do not cross the blood-brain barrier?
Neostigmine being a quaternary ammonium compound and highly polar cannot cross BBB.Pralidoxime which is used in OP poisoning also can&;t cross the BBB.Ref: Katzung 11th ed.Pg 121
Diacetyl monoxime
Obidoximine
Physostigmine
Neostigmine
Anesthesia