Mutation in COL4A5 chain the diagnosis ?
Ans. is 'a' i.e., Alpo's syndromeo Manifestations of Alpo's syndrome are due to abnormal a3 (COL4A3), a4 (COL4A4), or a5 (COL4A5). o This is due to mutations of :i) COL4A5 in classic X-linked formii) COL4A.3 or COL4A4 in autosomal forms.
Alpo's syndrome
Good pasture's syndrome
Hereditary Non-polyposis colon cancer
Keroderma pigmentosum