Hyperscretory granules seen in with lungCa
Small cell carcinoma: Small cell carcinomas are frequently hilar or central in location, have strong
relationship to cigarette smoking and are highly malignant tumours. They are most often associated with ectopic
hormone production because of the presence of neurosecretory granules in majority of tumour cells which
are similar to those found in argentaffin or Kulchitsky cells normally found in bronchial epithelium. By immunohistochemistry,
these tumour cells are positive for neuroendocrine markers: chromogranin, neuron-specific enolase (NSE) and synaptophysin.
Adeno Ca
Small cell Ca
Large cell Ca
Bronchoalveolar Ca