Select the false statement among the following?
* Lipid soluble drugs (nonpolar) have high volumes of distribution than drugs which are more polar* Volume of distribution may be increased in renal failure & hepatic failure due to fluid retention, altered body fluid. However high plasma protein binding reduces the Vd. Loading dose = volume of distribution x target plasma concentration Maintenance dose = clearance x target plasma concentration T 1/2 is constant in first order kinetics T 1/2 is directly propoional to plasma concentration in zero order kinetics Clearance is indirectly propoional to plasma concentration
Lipid soluble drugs tend to have higher distribution
Volume of distribution is reduced by high plasma protein binding
Loading dose is equal to Vd divided by target plasma concentration
T1/2 is constant in first order kinetics
Pharmacodynamics