'Knudson's two-hit' hypothesis is associated with-
Harshmohan textbook of pathology 7th edition. Familial retinoblastoma comprises 40% of cases and may be bilateral . In this cases all somatic cells inherit one mutant RBgene from a carrier parent. Later during life the other mutational event of 2nd allele affecting the somatic cells occurs. This forms the basis of two hot hypothesis given by Knudson in 1971..
Retinoblastoma
Melanoma
Ulcerative colitis
Crohn's disease
General pathology