Drug of Choice for hypehyroidism in pregnancy:
In a case of thyrotoxicosis during pregnancy, lodine-131 is contraindicated. Propylthiouracil is the drug of choice for thyrotoxicosis in pregnancy. It is highly protein bound and therefore less amount of drug is transferred across placenta and in milk. With carbimazole and methimazole there is risk of fetal hypothyroidism, aplasia cutis, and fetal agranulocytosis.
Methimazole
Carbimazole
Propylthiouracil
I-131
Medical Illness Complicating Pregnancy