Which of the following increases the susceptibility to coronary artery disease -
• Nephrotic syndrome is a clinical complex characterized by proteinuria (> 3.5 g/day), hypoalbuminemia, edema and hyperlipidemia.
• A hypercoagulable state frequently accompanies severe nephrotic syndrome due to urinary loss of AT-III, reduced serum levels of protein C and S, hyperfibrinogenimia and enhanced platelet aggregation.
• Due to increased coagulation state, predisposition to CAD is present in patients with nephrotic syndrome.
Potential future questions
Among hyperlipoproteinemias type II, III and IV are associated with increased risk of CAD whereas Type I and V are not associated with CAD.
Type V hyperlipoproteinaemia
Von willebrand's disease
Nephrotic syndrome
Systemic lupus erythematosus