A 35-year-old man presents with symptoms of jaundice, right upper quadrant pain, and vomiting. His ALT is elevated. He is diagnosed with HAV infection after eating at a restaurant where others were also infected. Which of the following should be done to protect his 68-year-old father and his 6-month-old son?
Since this was diagnosed and confirmed as a Hepatitis A infection, there is little likelihood of long-term sequelae. However, persons over 40 and those younger than 12 months are more likely to have severe manifestations. One dose of standard y-globulin (b), which contains antibodies from a series of normal population individuals, will provide passive protection to the family members for several weeks due to the presence of antibodies against HAV. Vaccination with the killed HAV vaccine (c), which is recommended by CDC ( style="font-size: 1.04761904761905em; font-family: Times New Roman, Times, serif">), is for those in the 12 months to 40 years age bracket. IFN-a (a) treatment is approved only for HBV and HCV infections. HAV transmits readily, so the quarantine and observe approach (d) and the no-treatment option (e) will not guarantee that transmission will not occur within the family.
Administer IFN-a to both
Give each one dose of g-globulin
Immunize both with one dose of hepatitis A vaccine
Quarantine household contacts and observe
Virology