IL -1 produces -
Ans. is 'a' i.e., T-Iymphocyte activation . Also known as leucocyte activating factor (LAF) or B cell activating factor (BAF). . Principally secreted by macrophages and monocytes; and epithelial cells. . Other sources are B lymphocytes, fibroblasts and endothelial cells. . Immunological effects? - Activation of T cells for the production of IL - 2. - B cell proliferation and antibody synthesis - Neutrophil chemotaxis and increased PMN release from bone marrow. - Increases body temperature (impoant endogenous pyrogen). - Bone marrow cell proliferation - Induction of acute phase protein.
T lymphocyte activation
Delayed wound healing
Increased pain perception
Decreased PMN release from bone marrow