Alport syndrome is characterized by antibodies act against?
Ans is 'c' i.e. Collagen IV o Alport syndrome is a type hereditary nephritis characterized by glomerulonephritis, sensorineural hearing loss and eye defects. It is due to defect in a -5 chain of collagen IV (COL4 A5).o The most common inheritence is X-linked which causes defect in a -5 chain of collagen IV. Very rare autosomal forms (dominant and recessive) also exist, which affect a-3 or a-4 chains of collagen 4 (COL 4 A3 or COL 4 A4).
Laminin
Fibronectin
Collagen IV
Heparan sulphate
Miscellaneous (Urinary Tract)