Gastrointestinal stromal tumor (GIST) occur from mutation of-
GIST is the most common mesenchymal tumor of the abdomen PATHOGENESIS Approximately 75% to 80% of all GISTs have oncogenic, gain-of-function mutations of the gene encoding the tyrosine kinase c-KIT, which is the receptor for stem cell factor. Another 8% of GISTs have mutations that activate a related tyrosine kinase, platelet-derived growth factor receptor A (PDGFRA); thus activating mutations in tyrosine kinases are found in viually all GISTs. However, either mutation is sufficient for tumorigenesis, and c-KIT and PDGFRA mutations are almost never found in a single tumor. GISTs appear to arise from, or share a common stem cell with, the interstitial cells of Cajal, which express c-KIT, are located in the muscularis propria, and serve as pacemaker cells for gut peristalsis. TEXT BOOK OF ROBBINS BASIC PAYHOLOGY NINTH EDITION PAGE.572 IMAGE REF:
c-KIT oncogene
c-KTT oncogene
c-KTT oncogene
c-RET oncogene
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