In G6PD deficiency, which cells are more prone for hemolysis:
- Mature red cells do not synthesize new proteins - Hence, as red cells ages G6PD enzyme levels fall quickly & becomes inadequate to protect against oxidant stress. - Thus, older red cells are much more prone to hemolysis than younger ones.
Older red cells
Young red cells
Reticulocytes
All are susceptible
Hemolytic anemia