Mechanism of action of vincristine in the treatment of ALL is:
Vinca alkaloids like vincristine and vinblastine act by inhibiting the formation of mitotic by spindle inhibiting polymerization of tubulin. These drugs are selective for M phase of cell cycle.
Inhibition of topoisomerase II to cause breaks in DNA strands
Alkylation and cross linking DNA strands
Inhibition of DNA mediated RNA synthesis
Inhibition of polymerization of tubulin to form microtubules
Cytotoxic Anticancer Drugs