Plasmapheresis (plasma exchange therapy) is used in the treatment of
Ans. is 'c' i.e. Thrombotic thrombocytopenic purpura Plasmapheresis is useful in the treatment ofThrombotic thrombocytopenic purpuraGuillain Barre SyndromeChronic inflammatory demyelinating polyneuropathy.Cryoglobulinemia glomerulopathyGood pasture's diseaseHemolytic uremic syndromeMultiple sclerosisMyasthenia GravisPauci immune glomerulonephritisPoison elimination Treatment of T.T.PPlasmapheresis is the mainstay of therapy for thrombotic thrombocytopenic purpura.The therapy of Thrombotic thrombocytopenic purpura is based on intensive plasmapheresis coupled with infusion of fresh frozen plasma.Therapy removes abnormal forms of VWF, lower the concentration of ADAMTS13 inhibitor and replenish the deficient enzyme. Overall mortality is markedly reduced and majority of patients with T.T.P recover. Most of the patients survive the acute illness, recover completely with no residual renal or neurologic disease.Plasmapheresis has also been used in hemolytic uremic syndrome but it not been as successful as T.T.P.Management of Hemolytic uremic syndrome early dialysisFor acute renal failure and general supportive care including t/t of hypertension.Refractory casesVincristine or cyclosporine Steroids and Antiplatelet agentsQuestionable benefit Fibrinolytic therapyIneffective Platelet transfusionCan worsen the patients status
Autoimmune hemolytic anemia
Disseminated intravascular coagulation
Thrombotic thrombocytopenic purpura
Hemolytic uremic syndrome
Transfusion