Fluconazole differs from ketoconazole in the following aspect
Fluconazole is a preferred agent because it has

Very good oral absorption.
Maximum CNS penetration. (therefore effective in cryptococcal meningitis).
No inhibitory action on microsomal enzymes.
No anti-androgenic property.
It is not active by the oral route
It is a more potent inhibitor of drug metabolism
It is not effective in cryptococcal meningitis
It is unlikely to produce anti-androgenic side effects