Listeria resists phagocytosis in phogosomes (phagolysosomes) due to -
Ans. is 'a' i.e., b - hemolysin o Most important step in pathogenesis of listeriosis is the survival and multiplication of L monocytogenes in phagocytes (macrophages), host epithelial cells and hepatocytes.o The most important determinant of pathogenesis is listeriolysin O (LLO), a b- hemolysin. LLO causes lysis of membrane of phagosomes within phagocytes and helps in intracellular survival of L monocytogeneso Iron is an important virulence factor. Listeria produce siderophores and are able to obtain iron from transferringo Immunity to listeria is primary cell mediated. Immunity can be transferred by sensitized lymphocytes but not by antibodies.
b-hemolysin
Caspases
Cell membrane adhesion molecules
Opacity associated protein (OAP)
Listeria Monocytogenes