A 34 year old patient presented with thyroid nodule. Ultrasonography of the thyroid nodule shows foci of calcification. Histological features are shown in the diagram below, what is your likely diagnosis?
Given histopathological slide shows branching papillae having a fibrovascular stalk covered by a single to multiple layers of cuboidal epithelial cells. These features along with given history point towards papillary carcinoma of thyroid. Nuclei of papillary carcinoma cells contain finely dispersed chromatin, which impas optically clear / empty appearance, giving rise to ground-glass nuclear appearance or Orphan annie eye nuclei. In addition, invagination of cytoplasm may give appearance of intranuclear inclusions ("pseudo-inclusions") / intranuclear grooves. These nuclear features are sufficient for diagnosis of papillary carcinoma,even in absence of papillary architecture. Concentrically calcified structures termed Psammoma bodies are often present, usually within cores of papillae.
Follicular carcinoma
Medullary carcinoma
Papillary carcinoma
Anaplastic carcinoma
Thyroid Tumor