Which one of the following is true of hyaline membrane disease of the newborn –
In HMD surfactant is reduced and its measurement can be used for diagnosis e.g. in shake test.
Constituent of surfactant are - dipalmitoyl phosphatidylcholine (lecithin), phosphatidylglycerol, apoproteins (surfactant proteins SPA, SPB, SPC, SPD) and cholesterol.
Prematurity provides relative protection of the occurrence
Maternal steroid exposure increase severity of the disease
Phosphatidyl glycerol estimation is a reliable method of diagnosis
Surfactant increases the surface tension of a iveoli