Which of the following is a Ketolide antibiotic?
ANSWER: (C) TelithromycinREF: Katzung 12th edition page 814, 815KETOLIDE ANTIBIOTIC:Ketolidesare semisynthetic 14-membered-ring macrolides, represented here by telithromycin - the first ketolide on the market, are new-generation macrolides, in which a 3-keto group replaces 1-dadinose in the lactone ring.Ketolides and macrolides have very similar antibacterial propertiesTelithromycin: Telithromycin is the first ketolide antibiotic to enter clinical use >* Oral bioavailablity is 57%Good tissue penetrationMetabolized by liverEliminated by both biliary and urinary routes.Reversible CYP P450 inhibitorProlongs QT intervalOnly approved indication is community acquired pneumonia because it can cause hepatitis and liver failure.
Erythromycin
Azithromycin
Telithromycin
Calathromycin
Anti Microbial