Rofecoxib as compared to indomethacin is :
Selective COX-2 inhibitors are less likely to cause GI complications like PUD. However a COX-2 is also present constitutively in the kidney, chances of renal complications are similar. These drugs have similar or less efficacy than non-selective COX inhibitors.
Less likely to cause gastric ulcer and their complications
Likely to be more effective in rheumatoid arthritis
Not likely to produce renal complications
All of the above