Acantholysis is due to destruction of :
Ans. is 'c' Intercellular Substance It is loss of cohesion b/w epidermal cells due to destruction of intercellulare substance. IgG Antibodies are formed against the intercellular substance.Acantholysis occurs in stratum Basale in Pemiphus Vulgaris*Acantholysis is demonstrated by Nikolsky's sign*Acantholytic cells are demonstrated by Tzanck smear*
Epidermis
Subepidermis
Intercellular substance
Basement membrane
Vesiculobullous (Blistering) Disorders