COX 2 inhibits the following step in inflammation:
COX-1, expressed constitutively in most cells, is the dominant source of prostanoids for housekeeping functions, such as gastric epithelial cytoprotection and hemostasis. Conversely, COX-2, induced by cytokines, shear stress, and tumor promoters, is the more impoant source of prostanoid formation in inflammation. COX-2 is found in endothelial cells and inflammatory cells. In endothelial cells, COX-2 initiates the synthesis of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. Ref: Weitz J.I. (2012). Chapter 118. Antiplatelet, Anticoagulant, and Fibrinolytic Drugs. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.
Cell adhesion
Cell differentiation
Cell migration
Platelet aggregation