Patient is treated with dentrolene. All the following are adverse effects except:
- Central muscle relaxant - Used in malignant hypehermia, neuroleptic malignant syndrome etc- Cause respiratory muscle weakness - breathlessness- Chronic dantrolene use - liver dysfunction, kidney dysfunction- Bradycardia Dantrolene contributes to prolonged non depolarizing neuromuscular blockade, In addition to volatile anesthetics, other drugs, such as aminoglycoside antibiotics, local anesthetics, cardiac antiarrhythmic drugs, dantrolene, magnesium, lithium, and tamoxifen (an anti-estrogenic drug), may enhance the neuromuscular blockade produced by nondepolarizing NMBDs. A few drugs may diminish the effects of a nondepolarizing NMBD, including calcium, coicosteroids, and anticonvulsant (phenytoin) drugs.
Hypokalemia
Muscle weakness
Breathlessness
Bradycardia
JIPMER 2017