Mechanism of action of paclitaxei is -
Ans. is 'b' i.e., Increase the polymerization of tubulin Tasaneso Pacliiaxel and docetaxei function as a mitotic spindle poison through high affinity' binding to microtubules with enhancement of tubulin polymerization.o The microtubules are stabilized and their depolymerization is prevented - inhibition of mitosis and cell division.o Paclitaxel is metabolized in liver and undergoes enterohepatic circulation - dose should be reduced in liver dysfunction.o Paclitaxel can cause hypersensivitv reaction which does not occur with a novel albumin-bound paclitaxel preparation.o Paclitaxel and docetaxei both can cause bone marrow depression & peripheral neuropathy.
Topoisomerase inhibition
Increase the polymerization of tubulin
Inhibition of protein synthesis
Alkylation of DNA
Anti-Neoplastic Agents