Which of the following does not indicate megaloblastic anemia
Ans. a. Increased reticulocyte count Megaloblastic anemia is characterized by hypercellular bone marrow with abnormally large nucleated RBC, raised unconjugated bilirubin and mild splenomegaly Characteristic Features of Megaloblastic Anemia Bone marrow: Hypercellular with a decreased myeloid/erythroid ratio and abundant stainable iron RBC precursors: Abnormally largedeg and have nuclei that appear much less mature than would be expected from the development of the cytoplasm (nuclear-cytoplasmic asynchronydeg). Nuclear chromatin is more dispersed than expected and it condenses in a peculiar fenestrated patterndeg Raised unconjugated bilirubindeg Mild reversible splenomegalydeg (Wintrobes 12/e p1151)
Increased reticulocyte count
Raised Bilirubin
Mild splenomegaly
Nucleated RBC