Which of the following statement is false regarding phenobarbitone?
Phenobarbitone induces metabolism of warfarin BARBITURATES Phenobarbitone and primidone act as anticonvulsant drugs due to GABA mimetic as well as GABA facilitatory propeies. These drugs increase the duration of opening of chloride channels. These drugs are useful in generalized tonic clonic seizures (GTCS) and paial seizures. These drugs are highly sedating but tolerance develops to this effect. Phenobarbitone is a powerful enzyme inducer and increase the metabolism of several drugs including warfarin. Barbiturates are contraindicated in acute intermittent porphyria. These drugs can cause paradoxical excitation in some patients. Phenobarbitone is drug of choice for GTCS in infants but can cause hyperkinesia in older children.
It acts primarily at the GABA: BZD receptor -chloride ion channel complex
It can cross the placenta
Contra-indicated in Acute intermittent porphyria
It has no significant drug interactions with warfarin
Sedative-Hypnotics and Parkinsonism