Patient with hemophilia A have bleeding disorder because of:
Hemophilia A - X- linked disorder -90% cases- deficiency of factor 8 -10% cases - functional defect of factor 8 -Intrinsic Pathway affected -Factor VIIIa complex is the most impoant activator of factor X required for conversion of prothrombin to thrombin. -In symptomatic cases there is a tendency toward easy bruising and massive hemorrhage after trauma or operative procedures
Lack of platelet aggregation
Lack of reaction accelerator during activation of factor X in coagulation cascade
Neutralization of antithrombin III
Release of Thromboxane A2
Bleeding disorder