Drugs causing macular toxicity when given intravitreally?
(Refer: AK Khurana Comprehensive Ophthalmology, 6th edition, pg no. 445)Intravitreal aminoglycosides (gentamycin, amikacin) are a repoed cause of macular toxicityAminoglycosides induced macular toxicity is thought to be paially due to the gravity-induced settling of drugs on the macula in the supine positionThis may result in a higher concentration of drug locally at the macula.
Gentamycin
Vancomycin
Dexamethasone
Ceftazidime
Miscellaneous