Mechanism of action of paclitaxel is :
Taxanes (paclitaxel and docetaxel) act by increasing the polymerization of tubulin whereas vinca alkaloids (vincristine, vinblastine and vinorelbine) cause inhibition of tubulin polymerization. Both of these drugs act by causing the disruption of mitosis and are active in M-phase of the cell cycle.
Topoisomerase inhibition
Increases the polymerization of tubulin
Inhibits protein synthesis
Alkylation of DNA