The MOST severe complication of idiopathic hyper-eosinophilic syndrome is:
The most severe complicaions are involving hea and CNS. In the hea pathologic changes leads to thrombosis, endocardial fibrosis and restricve cardiomyopathy. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 481
Endocardial fibrosis
Eosinophilic gastroenteritis
Interstitial pneumonia
Bone marrow failure