The most appropriate drug used for chelation therapy in beta-thalassemia major is :
Drug of choice for acute iron poisoning is desferrioxamine, however it has to be administered parenterally. It is not effective by oral route.
In beta thalassemia major, iron excess can result due to repeated blood transfusions and massive hemolysis. Chelating agent has to be administered for long time in this case. Therefore, oral Deferiprone is preferred in this case.
Oral Desferrioxamine
Oral deferiprone
Intramuscular EDTA
Oral succimer