What is the mode of inheritance of Hereditary spherocytosis?
- Hereditary spherocytosis is inherited in an Autosomal dominant pattern. - Results from instability of spectrin & ankyrin which are major skeletal membrane proteins. - Degree of protein deficiency correlates with degree of hemolysis. - Demonstrated by Increase in osmotic fragility after 24hrs incubation of blood at 37oC.
Autosomal dominant
Autosomal recessive
X-linked recessive
X-linked dominant
Hemolytic anemia