Commonest presentation of sickle cell anaemia is
Sickle cell anemis causes Vaso-occlusive crisis : This means plugging of small vessels in the bone produces severe bone pain. This affects areas of active marrow: the hands and feets in children(dactylitis) or femora, humeri, ribs, pelvis and veebrae in adults. Reference : Davidson, 23rd Edition, page no : 952.
Priapism
Bone pain
Fever
Splenomegaly
Haematology