Uremia occurs when total GFR is reduced by-
There is no specific time for the onset of uremia for people with progressive loss of kidney function. People with kidney function below 50% (i.e. a glomerular filtration rate between 50 and 60 mL) and over 30 years of age may have uremia to a degree. Ref: Wikipedia
25%
50%
60%
80%
Urinary tract