True about Wilson’s disease
In Wilson’s disease, there is almost always a failure of synthesis of ceruloplasmin; however, some 5% of patients have a normal circulating ceruloplasmin concentration and this is not the primary pathogenic defect. The amount of copper in the body at birth is normal but thereafter it increases steadily; the organs most affected are the liver, basal ganglia of the brain, eyes, kidneys and skeleton.
Decreased urinary excretion of copper
Increased ceruloplasmin in blood
Decreased copper and ceruloplasmin in serum
Decreased urinary excretion of ceruloplasmin