A 70 Year old male complains of ulceration on Lower lip since 1 moth with Lymph node involvement. Patient has history of tobacco chewing since 30 years 6-7 times per day, patient also complains of loss of weight since 2 months and change in voice since one month

A reliable clinical condition to consider for the diagnosis as malignancy is
An ulcerative lesion
An ulcerative and painful lesion
Ulceration and fixation of the lymph node
Bilateral involvement of lymph node