The antiepileptic drug which causes weight loss:
(Ref: Katzung 14th ed. pg. 427-28)* The only antiepileptic drug which causes weight loss: Topiramate, Zonisamide* MOA of topiramate:# VG-Na+ channel blocker# Activate GABA receptor# Inhibit AMPA receptor (receptor of Glutamate)* Use:# GTCS, Partial seizure# Maintenance therapy of alcohol withdrawal# LGS# Decreases alcohol craving* Side effects: Urolithiasis, Somnolence
Valproate
Vigabatrin
Topiramate
Felbamate
C.N.S