Busulfan may cause: September 2007
Ans. B: Pulmonary Fibrosis Toxicity of busulphan may include: Interstitial pulmonary fibrosis Hyperpigmentation Seizures Hepatic (veno-occlusive disease) Wasting syndrome. Phenytoin may be used concurrently to prevent the seizures. Levetiracetam, has shown efficacy for the prophylaxis against busulfan-induced seizures. Benzodiazepines can also be used for busulfan-induced seizures.
Cystitis
Pulmonary fibrosis
Loss of hair
Peripheral neuropathy