All of the following are true regarding the actions of endothelin-1 except ?
Endothelin-1 Potent vasoconstrictor agent Produced by endothelial cells. They are secreted locally and act in a paracrine fashion. Actions of Endothelin-1 (ET-1) Potent vasoconstrictor Platelet activation Inotrophic effect Closure of ductus aeriosus Have a role in the pathogenesis of hypeension, myocardial infarction, and congestive hea failure. In the brain, regulate the transpo of substances across blood brain barrier (BBB).. In the kidneys, they are involved in tubuloglomerular feedback- decreased GFR In the lungs, it causes bronchoconstriction (mediated ET-B receptors) In GIT, they are involved in the migration of myenteric plexus to distal colon (failure leads to Hirschsprung&;s/ Megacolon) Deletion of both alleles of ET-1 gene- craniofacial abnomalities and respiratory failure at bih. Ref: Ganong&;s Review of Medical Physiology 26th edition PGno: 584
Bronchodilation
Vasoconstriction
Decreased GFR
Has inotrophic effect
General anatomy