Imipenem is combined with cilastatin to:
Ans. (A) Cilastatin prevents degradation of imipenem in kidney(Ref: Goodman and Gilman 13th/e p1035)Imipenem is rapidly inactivated by renal dehydropeptidase I, so it is combined with cilastatin, an inhibitor of this enzyme.Cilastatin increases the half life of imipenem and also inhibits the formation of nephrotoxic metabolite.Meropenem, doripenem and ertapenem are not metabolized by renal dehydropeptidase
Cilastatin prevents degradation of imipenem in kidney
Cilastatin inreases intestinal absorption of imipenem
Cilastatin inhibits beta lactamase activity
Both have synergistic activity against Pseudomonas
Anti Microbial