Keratin 5 and 14 are produced in which layer
Stratum Basale It has mitotically active cuboidal cells from which the upper layers of the epidermis are derived. Attached to dermis by hemidesmosomes. Keratins 5 and 14 produced here. Cellular proliferation stimulated by various factors, including trauma and UV (|ornithine decarboxylase expression is associated with (a/w) proliferative states). Ornithine decarboxylase is inhibited by coicosteroids, retinoids, and vitamin D3. 10% of cells in the basal layer are stem cells, which give rise to other stem cells and transient amplifying cells that can still replicate, but only for a few cycles, until they reach a terminal differentiation phase, where they move upwards and eventually desquamate. Ref:- Review of Dermatology by Alikhan; pg num:- 1,2
stratum corneum
stratum granulosum
stratum spinosum
stratum basale
Anatomy of skin