Following statement is true for hemophilia patients?
Ans. is 'c' i.e., Females are mostly carriers and all males are affected Hemophilia is an X-linked recessive hemorrhagic disease due to mutations in the F8 gene (hemophilia A or classic hemophilia) or F9 gene (hemophilia B). The disease affects I in 10,000 males worldwide, in all ethnic groups; hemophilia A represents 80% of all cases. Male subjects are clinically affected; women, who carry a single mutated gene, are generally asymptomatic. Family history of the disease is absent in 30% of cases and in these cases, 80% of the mothers are carriers of the de novo mutated allele.
All Females are carriers and all males are affected
All Males are carriers and all females are affected
Females are mostly carriers and all males are affected
Males are mostly carriers and all females are affected