All are true regarding Toxoplasmosis, except -
Toxoplasmosis Transmission increases from 1st to 3rd trimester Severity decreases from 1st to 3rd trimester Option 1 Toxoplasmosis in Adult - Mostly asymptomatic Option 2 Congenital toxoplasmosis: 1st Trimester: More severe infection 3rd Trimester: More chance of transmission If Mother is previously infected: Fetus is asymptomatic. Incidence: Approximately 1 per 1000 live bihs. Featured by: 3C + 2M (chorioretinitis, cerebral calcification, convulsion, microcephaly and mental retardation) Most common manifestation: Chorioretinitis Option 3 Congenital toxoplasmosis Diagnosis: IgM detection in fetal blood, IgA can also be used. Toxoplasma Ag in amniotic fluid, PCR to detect Toxoplasma genes. Option 4 Congenital infection occurring in 1st trimester of pregnancy may cause aboion and still bih, but when acquired late in pregnancy, it may produce retinitis and mental defects.(less severe)
Subclinical in most cases among adults
Intracerebral calcification in children
IgM Ab in new born suggests congenital infection
More severe in 3rd trimester in pregnancy
Parasitology Pa 1 (Protozoology)