Hypophosphatemia is caused by-
Ans. is 'b' i.e., Primary hyperparathyroidism Causes of hypophosphatemia Internal redistribution Decreased intestinal absorption Increased urinary excretion o Increased insulin secretion o Inadequate intake o Primary' and secondary particularly during feeding o Antacids containing hyperparathyroidism o Acute respiratory alkalosis aluminum or magnesium o Vitamin D deficiency or o Hungry' bone syndrome o Steatorrhoea or chronic diarrhea resistance o Catecholamines o Vitamin D deficiency or resistance a Hereditary hypophosphatemia o Recovery' from starvation rickets or acidosis o Oncogenic osteomalacia o Gram negative sepsis o Fanconi syndrome o Other acetazolamide o Bartter syndrome Clinical feature of intracellular phosphate depletion o Most of the syndrome of hypophosphatemia are due to two consequences of intracellular phosphate depletion which virtually affect all organ system. o Red cell 2, 3- DPG (diphosphoglycerate) level falls, Thereby increasing the affinity1 of hemoglobin for oxygen and reducing oxygen release at the tissue level o Intracellular A TP level falls With severe hypophosphatemia those cell function that depend upon the energy rich phosphate compounds begin to fail. Effect of hypophosphatemia on various organs
Primary hypothyroidism
Primary hyperparathyroidism
Primary hyperthyroidism
Hypoparathyroidism