The therapeutic efficacy of antihypeensive drugs is blunted by NSAIDs because of :
NSAIDs inhibit Prostaglandin production including PGI2 which causes vasodilatation Ref: KD Tripathi 8th ed
Cause sodium excretion
Increase in the clearance of antihypeensive drugs
Decrease in the absorption of antihypeensive drugs
Decrease in the synthesis of vascular prostacyclin
Autacoids