Anti-TNF alpha drugs are used for the treatment of all of following diseases except
Ans. (A) Systemic lupus erythematosus(Ref: Harrison 17/e p2039; KDT 8/e p943)There is already under-expression of TNF-a in SLE, therefore we cannot use anti-TNF drugs for this condition. It is further strengthened by the fact that anti-TNF alpha drugs like infliximab cause SLE as the adverse effect.Indications for TNF-a inhibitorsRheumatoid arthritisJuvenile arthritisPsoriatic arthritisPsoriasisAnkylosing spondylitisCrohn's disease
Systemic lupus erythematosis
Seronegative arthritis
Psoriatic arthritis
Crohn's disease
Immunomodulatory: DMARDS, Monoclonal Antibodies