Which of the following is NOT secreted in pancreatic tumour :
Answer is none or D (None or ACTH) VIP, Insulin Somatostatin and ACTH may all be secreted from pancreatic endocrine tumors. Amongst the options provided ACTH is the most rare peptide associated with Pancreatic Endocrine Tumors, and hence may be selected as the single best answer of exclusion. Insulin > VIP > Somatostatin (Rare) > ACTH (Rare) Name Biologically active Peptides secreted (New Cases/106 Population/ Year) Tumour location Zollinger Ellison Syndrome Gastrin 0.5-1.5 Duodenum (70%) Pancreas (25%) VIPoma (Verner Morrison Syndrome, Pancreatic cholera, WDHA) VIP 0.05 - 0.2 Pancreas (90% in adult) Glucagonoma Glucagon 0.01 - 0.1 Pancreas (100%) Insulinoma Insulin 1 - 2 Pancreas (> 99%) Somatostatinoma Somatostatin Rare Pancreas (55%) Duodenum-Jejunum (44%) GRFoma Growth hormone releasing hormone Unknown Pancreas (30%) Lung (54%) ACTHoma ACTH Rare Pancreas
VIP
Insulin
Somatostatin
ACTH