The mechanism of action of Sofosbuvir?
Sofosbuvir is used orally for Hep C. Orally given once daily in combination with ledipasvir or ribavirin or PEG-interferon for 24 weeks. It is a Hep C NS5B polymerase inhibitor. Ref: HL.Sharma 3rd ed. Pg 800
Inhibits RNA dependent RNA polymerase of HCV
Inhibits DNA dependent RNA polymerase of HCV
Inhibits RNA dependent RNA polymerase of HBV
Inhibits DNA dependent RNA polymerase of HBV
Gastrointestinal tract