All are true about Leptin EXCEPT:
Leptin is a protein secreted by adipocytes (of the white adipose tissue). It is related to cytokines; hence sometimes it is called adipocytokine. Option D is a correct. It is sends signals to the hypothalamus regarding the degree of adiposity and nutrition, which in turn controls eating behavior and energy expenditure. Option C is a correct. As fat stores increase, plasma leptin levels increase (option B); and, as the fat stores are depleted, leptin levels decrease. High leptin levels inhibit the neuropeptide Y (NPY) secreting neurons of the hypothalamus. NPY is an orexigenic agent; inhibition of NPY neurons will decrease the appetite and food intake.Thus, option A is an incorrect. Diet-induced obesity, advanced age, and type II DM are associated with leptin resistance. Leptin signaling mechanism is ineffective in such conditions.
It increases appetite
It is increased in obesity
Its receptor is in hypothalamus
Expressed in adipose tissue
Endocrine System