All of the following statement about vincristine are true except
Ref-KDT 6/e 824,825 Vincristine is a vinca allkaloid. It acts in M-phase of cell cycle by inhibiting the formation of spindle. It is a marrow sparing drug and causes peripheral neuropathy as a prominent adverse effect. It is used for the treatment of hematological malignancies like Hodgkin's lymphoma and leukemias.It is ineffective against solid tumors.
It is cell cyclic specific and kills cells in the S phase
Its toxicity primarily affects bone marrow and epithelial structure
Folic acid reverses its toxic effects
It is a drug of choice for choriocarcinoma
Other topics and Adverse effects