Abnormalities in synthetic function of liver results in: (PGI Dec 2006)
Ans: A (|PT); B {Hyperbilirubinemia} & C (| Acute phase reactants) 411]Liver Function Test - Harrison 17th/ 1918"The most commonly used liver ''function" testsQ are measurements of serum bilirubin, albumin, and prothrombin timeQ. The serum bilirubin level is a measure of hepatic conjugation and excretion, and the serum albumin level and prothrombin time are measures of protein synthesis. Abnormalities of bilirubin, albumin, and prothrombin time are typical of hepatic dysfunctionQ"The aminotransferases (transaminases) are sensitive indicators of liver cell injury and are most helpful in recognizing acute hepatocellular diseases such as hepatitis. They include the aspartate aminotransferase (AST) and the alanine aminotransferase (ALT)-.Serum prothrombin time, collectively measures factors II, V, VII, and XQKupffer cells usually lie within the sinusoidal vascular space and represent the largest group of fixed macrophages'3 in the bodLiver abnormalities are diagnosed by assessing prothrombin time (PT *), direct & total serum bilirubin (hyperbilirubinemia), albumin, and levels of acute phase reactants (serum alanine & aspartate aminotransferase = ALT & AST)(r)Principal Function of Liver Ganona 22nd / 501Formation and secretion of bileQNutrient and vitamin metabolismQGlucose and other sugarsQAmino acidsLipids: Fatty acids, cholesterol, LipoproteinsFat soluble vitaminsWater soluble vitaminsInactivitation of various substancesToxinsQSteroidsOther hormonsesSynthesis of plasma proteins:Acute phase reactantsQAlbuminQClotting factors (e.g. II, VII, IX, X)QImmunity : Kupffer cells(r)
|PT
Hyperbilirubinemia
|Acute phase reactant
Disturbance in Kupffer cells
Liver and Gall Bladder