Which of the following is a Polygenic disorder:
d. Hypertension(Ref: Nelson's 20/e p 650, Ghai 8/e p 643)Polygenic disorders:Disorders caused by interactions between variant forms of genes and environmental factors.Occur when many polymorphisms, each with a modest effect and low penetrance, are co-inheritedE.g. HypertensionQ, Diabetes mellitus, Coronary Artery disease, Septal DefectsQ, Cleft lip
Cystic fibrosis
Phenylketonuria
Multiple sclerosis
Hypertension
Genetics And Genetic Disorders