False statement about Acyclovir is
(C) Doesn't work on other viruses # ACYCLOVIR is an antiviral drug.> Acyclovir is active only againist herpes group of viruses.> Both simplex and varicella zoster have been found to develop resistance to acyclovir during therapy the former primarily due to mutants deficiency in thymidine kinase activity.> This deoxiguanosine analogue antiviral drug requires a virus specific enzyme for conversion to the active metabolite that inhibits DNA synthesis and viral replication.> Acyclovir is preferentially taken up by the virus infected cells.> Because of selective generation of the active inhibitor in the virus infected cell and its greater inhibitory effect on viral DNA syn- thesis, acyclovir has low toxicity for host cells: a several hundred-fold chemotherapeutic index has been noted.> Acyclovir is active only against herpes group of viruses; H. simplex type I is most sensitive followed by H. simplex type II > varicella- zoster virus= Epstein-Barr virus; while cytomegalovirus (CMV) is practically not affected.> Both H. simplex and varicella-zoster virus have been found to develop resistance to acyclovir during therapy; the former primarily due to mutants deficient in thymidine kinase activity and the latter primarily by change in specificity of virus directed enzyme so that its affinity for acyclovir is decreased.
Useful and efficient only for recurrent herpes infections
Inhibits thymidine kinase
Doesn't work on other viruses
Metabolized and excreted through kidneys
Miscellaneous (Pharmacology)