Bone affection in scurvy is due to which of the following
The most clearly established function of vitamin C is the activation of prolyl and lysyl hydroxylases from inactive precursors, allowing for hydroxylation of procollagen. Inadequately hydroxylated procollagen cannot acquire a stable helical configuration or be adequately cross-linked, so it is poorly secreted from the fibroblasts. Those molecules that are secreted lack tensile strength, are more soluble, and are more vulnerable to enzymatic degradation.collegen is required for osteoid matrix formation. Reference: Robbins basic pathology, pg no:301
Poor mineralization of the osteoid tissue
Defective osteoid matrix formation
Defective calcification in osteoid
Increased degradation of osteoid tissue
Pediatrics, environment and nutrition