Periodic Acid Schiff (PAS) stain positive intra-alveolar material is seen in?
PAS material in alveoli is accumulated surfactant due to decreased turnover in pulmonary alveolar proteinosis. Characterized by dysfunction of alveolar macrophages which results in decreased surfactant clearance The same material may be coughed up by patients and described as chunky gelatinous plugs. Lipoid pneumonia will show fat globules in macrophages.
Alpha 1 antitrypsin deficiency
Pulmonary Alveolar Proteinosis
Abetalipoproteinemia
Lipoid pneumonia
Interstitial Lung Disease