The therapeutic efficacy of antihypeensive drug is blunted by NSAIDs because they:
Ans. is 'd' i.e., Decrease the synthesis of vascular prostacyclin o NSA IDs blunt the antihypeensive effect of diuretics. o Loop diuretics act paly (intrarenal hemodynamics) by increasing the synthesis of prostaglandins by stimulation of COX o Prostaglandins (especially PGE2 and PGI2) cause renal vasodilation, natriuresis and increased water clearance due to inhibition of the ADH action. o NSAIDs inhibit the synthesis of prostaglandins by inhibiting COX. Therefore, NSAIDs blunt the diuretic effect of loop diuretics.
Cause sodium excretion
Increase the clearance of antihypeensive drugs
Decrease the absorption of antihypeensive drugs
Decrease the synthesis of vascular prostacyclin