Drugs that can be used in kernicterus-
Ans. is 'a' i.e., Barbiturate Treatment of hyperbilirubinemia o The following are the treatment options for treatment of hyperbilirubinemia. A) Drugs (Pharmacological therapy) B) Phototherapy C) Exchange transfusion Pharmacological therapy Following drugs are used in hyperbilirubinemia ? 1) Barbiturates (Phenobarbitone) It is effective only if given to mother before delivery. It acts by inducing the conjugation of bilirubin --> Phenobarbitone is an enzyme inducer. 2) Metalloporphyrins (Tin-Sn & Zinc-Zn) o These compounds decrease the formation of bilirubin by inhibiting heme oxygenase. 3) Miscellaneous o Frequent milk feeding Prevents reabsorption of unconjugated bilirubin from intestine by reducing enterohepatic circulation. Charcol & agar --> These are bilirubin binding agents which prevent bilirubin reabsorption from gut.
Barbiturates
Benzodiazepines
Phenytoin
Chlorpromazine