Extracellular adenosine is increased by which of the following DMARDs?
Methotrexate: Methotrexate inhibits an enzyme 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase leading to accumulation of AICAR, which blocks adenosine deaminase. Thus adenosine accumulates and it decreases inflammation by acting on adenosine receptors.
Leflunomide
Sulphasalazine
Methotrexate
Hydroxychloroquine
NSAIDs, Gout and Rheumatoid Ahritis