Which of the following statements about the biodisposition of penicillins and cephalosporins is NOT accurate?
* Probenecid inhibits renal tubular secretion of penicillins (not reabsorption) * Beta lactams eliminated by biliary route are: -- Ampicillin -- Nafcillin -- Ceftriaxone -- Cefoperazone * Penicillin G has to be given by i.m. route because it is broken down by gastric acid (decreases oral bioavailability).
Oral bioavailability is affected by lability to gastric acid
Procaine penicillin G is used intramuscular injection
Renal tubular reabsorption of beta-lactams is inhibited by probenecid
Nafcillin and ceftriaxone are eliminated mainly biliary secretion
Cell Wall Synthesis Inhibitors