A PATIENT ON LITHIUM THERAPY DEVELOPED HTN,HE WAS STAED ON THIAZIDES FOR HYPEENSION .AFTER FEW DAYS HE DEVELOPED COARSE TREMORS AND OTHER SYMPTOMS SUGGESTIVE OF LITHIUM TOXICITY .EXPLAIN THE LIKELY MECHANISM ::
DRUG INTERACTION OF LITHIUM : THIAZIDE DIURETICS INCREASE THE LITHIUM TOXICITY LOOP DIURETICS AND K+ SPARING DIURETICS -- NORMAL OR INC. LITHIUM OSMOTIC DIURETICS AND CARBONIC ANHYDRASE INHIBITORS WILL DECREASE THE LITHIUM LEVELS. REF : KD TRIPATHI 8TH ED
THIAZIDE INHIBIT METABOLISM OF LITHIUM
THIAZIDE AXT AS AN ADD ON DRUG TO LITHIUM
THIAZIDE INCREASE THE TUBULAR REABSORPTION OF Li
THIAZIDE CAUSE LOSS OF WATER THERBY INCREASES Li LEVELS
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