A patient in the surgical ICU is in septic shock after surgery for perforated diverticulitis. His temperature is 102.3degF and his heart rate is 120 bpm. He is requiring dopamine for BP support. Which of the following drugs would be appropriate for use in this situation?
Recombinant activated protein C (drotrecogin) was shown to reduce mortality in severe septic shock, but not mild septic shock. The major side effect of recombinant activated protein C is bleeding. Anti-TNF antibody, IL-1 receptor antagonist, and antiendotoxin antibody have failed to change outcomes in randomized, prospective trials. Sodium nitroprusside is a vasodilator and would worsen septic shock.
Recombinant activated protein C
Antitumor necrosis factor (TNF) antibody
Interleukin-1 (IL-1) receptor antagonist
Antiendotoxin antibody
Miscellaneous