Hereditary spherocytosis is due to deficiency of: September 2007
Ans. A: Spectrin Hereditary spherocytosis (HS) is due to a deficiency of a protein called ankyrin. Ankyrins are cell membrane proteins (thought to interconnect integral proteins with the spectrin-based membrane skeleton) The ankyrin of red blood cells (erythrocytic ankyrin) is called ankyrin-R/ankyrin-1/ ANK1.
Spectrin
Pyruvate kinase
Cytokeratin
Integrin