Kallmans syndrome is associated with all of the following except
When congenital GnRH deficiency is associated with anosmia or hyposmia (an absent or grossly impaired sense of smell), the disorder is known as Kallmann&;s syndrome. Two genetic mutations associated with Kallman&;s Syndrome : KAL gene - X - linked inheritance (Xp22.3) encoding anosmin - 1. Gene encoding FGFR1 (Fibroblast growth factor - 1 receptor) - autosomal dominant form. Anosmin - 1 is a neural adhesion molecule that promotes migration of GnRH neurons and olfactory neurons, from the olfactory placode into the hypothalamus during embryonic development. REF : Shaw book of gynecology 9th Ed.
Amenorrhea
Excess stimulation of the HPO axis
Genetic mutation
Anosmia
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