PNH patients will be having deficient surface proteins that normally protect the red cells from activated compliments. What are the two deficient surface proteins?
The definitive diagnosis of PNH is based on the demonstration that a substantial propoion of the patient's red cells have an increased susceptibility to complement (C), due to the deficiency on their surface of proteins (paicularly CD59 and CD55). Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 884
CD 45 and CD 59
CD 51 and CD 59
CD 55 and CD 59
CD58 and CD 59