Which of the following treatment for menorrhagia is not suppoed by evidence?
Ethamsylate is known to reduce capillary fragility. Hence it is not effective for uterine bleeding which is more due to the vasodilator prostaglandins. Antiprostaglandins are used since NSAIDs reduce prostaglandin levels by inhibiting cyclooxygenase and decreasing the ratio of prostacyclin to thromboxane. Prostaglandin E2 synthesis Prostaglandin E binding sites are reduced as well.
Ethamsylate
Tranexamic acid
OCP
Progesterone therapy on days 5 -25
Normal Menstruation, Abnormal Menstruation, Menopausal Physiology and forsight of conception