For the generation of a vaccine to prevent attachment of diarrhoeagenic E. coli to the specific receptors in the gastro-intestinal tract, vaccine should be directed against which of the following fimbrial adhesions factor?
P-pilli are pyelonephritis associated pilli that are found an uropathic strains of E. coli and may play a role in pathogeneses of UTI. P pilli binds to Gal-Gal containing disaccharides of the globoseries of glycolipids. Globoseries of glycolipid are found primarily in the epithelial surface of urinary tract. E. coli which lack P pilli also lack the ability to produce UTI in experimental animals. They play no role in attachment of diarrheogenic E. coli to receptors in GIT and hence a vaccine against them would play no role in prevention of diarrhea from E. coli. Ref: Ananthnarayanan, 6th Edition, Page 253 ; Medical Microbiology By Greenwood, 14th Edition, Page 324 ; Irwin and Rippe's Intensive Care Medicine By Richard S. Irwin, 6th Edition, Page 1080 ; Foodborne Infections and Intoxications By Hans P. Riemann, 3rd Edition, Page 221.
CFA-1
CS-2
P Pilli
K88