Features of Parvovirus infection include
Ans. d (All of the above) (Ref. Harrison 18th/ Ch. 184)PARVOVIRUSIntroduction# smallest DNA viruses.# The virus is stable and retains infectivity after incubation at 60degC for 16 h.# The name B19 is derived from the code number of the human serum in which the virus was discovered.# B19 binds specifically to a cellular receptor, erythrocyte P antigen; this specific binding explains the tropism of B19 for erythroid progenitor cells, particularly pronormoblasts and normoblasts. Few persons who lack P antigen cannot be infected with B19.# Most commonly occurs as outbreaks of erythema infectiosum in schools during winter and spring months.Clinical Manifestations# Erythema Infectiosum- Erythema infectiosum is the most common manifestation of B19 and occurs in children (winter and spring).- Called fifth disease as it was classified in late 19th century as the fifth in a series of six exanthems of childhood.- Normally a mild illness, erythema infectiosum typically presents as a facial rash with a "slapped-cheek" appearance that is sometimes preceded by low-grade fever. Rash resolves in about a week but can recur.# Arthropathy- B19 infection in adults most commonly presents as acute arthritis (symmetric and peripheral), with rash.- It normally resolves in about 3 weeks and is nondestructive.# Transient Aplastic Crisis, pure red-cell aplasia and Chronic Anemia in Immunodeficient Patients.# Fetal and Congenital Infection- It is estimated that fewer than 10% of maternal B19 infections in the first 20 weeks of pregnancy lead to fetal death; usually attributable to the development of nonimmune hydrops fetalis.# Possible Clinical Associations- with several rheumatic diseases, most notably rheumatoid arthritis but also vasculitis (including polyarteritis, Wegener's granulomatosis, Raynaud's phenomenon, and giant cell arteritis), lupus erythematosus, dermatomyositis, and juvenile rheumatoid arthritis is noted. Other associations include those involving multiple systems: cardiac (myocarditis), hematologic (hemophagocytic syndrome, idiopathic thrombocytopenic purpura), hepatic (fulminant hepatitis), neurologic (meningoencephalitis), renal (glomerulonephritis), and respiratory (pneumonia).Diagnosis# Diagnosis most commonly relies on measurements of B 19-specific IgM and IgG antibodies.Rx# Erythema infectiosum and arthropathy usually requires no treatment.# Transient aplastic crisis is usually treated with erythrocyte transfusions.# In immunodeficient anemic patients, B19 infection should be treated with iv Igs.# Prophylaxis of B19 infection with immunoglobulin should be considered for patients with chronic hemolysis or immunodeficiency and for pregnant women.Also know:# Medically vital DNA viruses: parvoviruses, papovaviruses (e.g., HPVs, polyomaviruses), Adeno, Herpes, and Pox.
Arthralgia
Pure red cell aplasia
Lymphadenopathy
All of the above
Virology