Delayed prolonged bleeding is caused by
EndotheliumDirect injury to endothelial cells causes delayed prolonged bleeding because, endothelial cells are central regulators of hemostasis, the balance between the anti-and prothrombotic activities of endothelium determines whether thrombus formation, propagation or dissolution occurs.Robbins basic pathology 9th edition page no 79
Histamine
Leukocyte dependent injury
IL-I
Direct injury to endothelial cells
General pathology