Prostaglandin inhibiting action of aspirin is useful in the treatment of all of the following conditions, except:
Ans. (C) Uricosuria(Ref: KDT 8th/e p212, 213)Inhibition of PG synthesis is responsible for analgesic, antipyretic, anti-inflammatory and antiplatelet actions of aspirin. This action is also utilized in the treatment of PDA. High doses of aspirin cause uricosuria whereas therapeutic doses result in hyperuricemia. These effects are unrelated to its action on PG synthesis.
Analgesia and antipyresis
Closure of ductus arteriosus
Uricosuria
Anti-inflammatory and anti platelet aggregation
Prostaglandins