Which is the best prognosticator of survival from nasopharyngeal carcinoma?
WHO type PATHOLOGY Risk factor Other factors Survival/ Recurrence I 25% Keratinizing Squamous cell differentiated carcinoma Smoking Low risk population Older age Non familial factors 10% Survival II 12% Non keratinizing Squamous cell differentiated carcinoma EBV Preserved foods Familial factors 50% Survival III 60% Non keratinizing Squamous cell undifferentiated carcinoma EBV High risk population, Children Preserved foods Familial factors 60% Survival Best prognosis Type 3 NPC- Poorly differentiated, EBV Associated & Best prognosis The undifferentiated NPC havea higher local tumour control rate with therapy although theincidence of distant metastasis is also higher.
High angiogenesis in the tumor
WHO type III histology
Lung metastases
WHO type I histology
Nasopharynx