Which of the following statements about anti-epileptics is false
Ans. a. Phenytoin and carbamazepine act by prolonging Na+ channel activation Phenytoin and carbamazepine act by prolonging Na+ channel activation, it is a false statement. Phenytoin and carbamazepine limit the repetitive firing of action potentials evoked by sustained depolarization. This effect is mediated by slowing of the rate of recovery of voltage-activated Na+ channels from inactivation, an action that is both voltage-and use-dependent (greater effects if membrane is depolarized.)"-
Phenytoin and carbamazepine act by prolonging Na* channel activation
Carbamazepine is also used in trigeminal neuralgias
Diazepam is an anti-epileptic
Lamotrigine acts by GABA mediated Cl- channel opening