Anaplasia in Wilm's tumor is evident by-
ROBBINS BASIC PATHOLOGY. 10th edition. Chapter Genetic and Pediatric Diseases. Page no. 290. Approximately 5% of tumors contain foci of anaplasia (cells with large, hyperchromatic, pleomorphic nuclei and abnormal mitoses). The presence of anaplasia correlates with the presence of acquired TP53 mutations and the emergence of resistance to chemotherapy.
Increased mitosis
Pleomorphic nuclei
Large nucleus
p53 mutation
Pediatrics, environment and nutrition