Thalidomide is not used in
D i.e. HIV associated neuropathy Peripheral neuropathy is a dose limiting toxicity of thalidomide & not a therapeutic indicationQ. It causes painful sensory ganglionopathy & axonal neuropathy. Indications of Thalidomide - Erythema nodosum leprosum (ENL)Q: Only FDA approved use for treatment of cutaneous manifestations . of moderate to severe ENL and for maintenance therapy for prevention and suppression of cutaneous manifestations of ENL recurrence. - Severe, recurrent apthous stomatitisQ, especially in AIDS patients is common off label use. - Behects syndromeQ - Chronic graft versus host disease. * HIV associated colitis and wasting, multiple myeloma, myelodysplasia, chronic idiopathic myelofibrosis, glucocoicosteroid refractory fistulosis-Chron's disease, sarcoidosis, prurigo, stomatitis are other rare uses.
ENL
Bechet's syndrome
HIV associated Oral ulcers
HIV associated neuropathy