All of the following factors tend to increase the volume of distrubtion of a drug except
Ref-katzung 10/e per,35 If a drug is highly bound to plasma proteins ,it is more likely to stay in blood.thus it's Vd will be less . Low ionization ours the distribution of a drug because unionized molecules can cross the membrane of blood vessels and the tissue More lipid soluble drugs can easily cross the membrane and are more likely to be highly distributed
High plasma protein binding
Low ionization at physiological pH values
High lipid solubility
High tissue binding
Other topics and Adverse effects