True regarding endothelin-1 are all except
Endothelin 1 is a broncho constrictor that it is implicated in the pathophysiology of asthma Endothelin-1, one of the most potent vasoconstrictor agents yet isolated. Endothelins cause contraction of mesangial cells which reduce GFR Endothelin-1 appears to be primarily a paracrine regulator of vascular tone. Endothelin is a positive inotropic agent in human hea Ref: Ganong's Review of Medical Physiology Twenty-Third Edition Page No:565
Bronchodilatation
Vasoconstriction
Decreased GFR
Has inotropic effect
Cardiovascular system