All have effects on oxygen-hemoglobin dissociation curve except:
Ans: C (Chloride..) Ref: Fetal Hb, Hypothermia, Hypocarbia & alkalosis cause left shift of the curve. Right Shift cause more O2 delivery to tissue.Hb-O2 dissociation curveLeft ShiftingRight Shifting | 2, 3- BPG | 2, 3-BPG Alkalosis Acidosis Hypothermia Hyperthermia Foetal Hb High altitude Hypocarbia Excercise Stored blood Hypercarbia Hb Chesapeake Anaemia Hb Ranier Sickle cell anaemia HbM Diabetic Ketoacidosis Thyroid hormone Growth hormone Androgen Diseases causing chronic hypoxiaNote: Mb-O2 dissociation curve lies left to of Hb-O2 dissociation curveFactor Affecting Affinity of Hb for O2 - Ganong 667-69Three important condition affecting Hb-O2 dissociation curve - pH, temperature & concentration of 2, 3-BPG. A rise in temperature or fall in pH shift the curve to right. 2,3-BPG is very plentiful in red cell. It is formed from 3-phosphoglycoraldehyde (3-PGA], which is a product of glycolysis via the Embden-Meyerhof pathway. Because acidosis inhibit glycolysis., 2,3-BPG concentration falls when pH is low. Thyroid hormone, Growth hormone, & androgen increase the concentration of 2, 3-BPG & the P50 The affinity of foetal Hb (HbF) for O2, which is greater than that of adult Hb (HbA), shifts the curve to left,Excercise has been reported to produce an increase in 2,3- BPG within 60 minutes .although the rise may not occur in trained athletes. The P50 is also increased during excercise. Ascend to high'4 altitude trigger a substantial rise in 2,3-BPG concentration. The rise in 2, 3-BPG, which has a half-like of 6 hours, is secondary to the rise in blood pH. 2,3-BPG level drops to normal on return to sea level."Certain Hb like sickle cell anaemia shift the O2 dissociation cu rve to right"- Kumar & Clark 4th/357 & 6th/430"HbM O2 affinity is much lower than normal HbA while O2. affinity of Hb Chesapeake & Rainier is more "- Chatterjea & Shinde 7th/ 149"Because Mb-O2 dissociation curve lies left5 of Hb-O2 dissociation curve, it takes up O2 from Hb in the blood"- Ganong 22nd/669
2,3-DPG
CO, pressure
Chloride ion
Acidosis
Principles of Gas Exchange -  Respiratory Membrane