What is the most serious adverse effect of streptomycin?
Streptomycin (S) This is a tuberculocidal aminoglycoside. It is not absorbed orally and must be administered by IM injection. It is active only against extra-cellular bacteria. It is NOT HEPATOTOXIC. Major adverse effects are ototoxicity, nephrotoxicity and neuromuscular blockade. Streptomycin is contraindicated in PREGNANCY.
Hepatotoxicity
Ototoxicity
Ocular toxicity
Hematological disturbances
Protein Synthesis Inhibitors