Mechanism of action of paclitaxel is -
Ans. is 'b' i.e., Increases the polymerization of tubulin o Paclitaxel and docetaxel function as a mitotic spindle poison through high affinity binding to microtubules with enhancement of tubulin polymerization. o The microtubules are stabilized and their depolymerization is prevented inhibition of mitosis and cell division.
Topoisomerase inhibition
Increases the polymerization of tubulin
Inhibits protein synthesis
Alkylation of DNA