Warfarin induced skin necrosis is seen in:
It is due to decreased levels of protein C. It is more likely to occur in patients with genetic deficiency of protein C. Most common side effect of warfarin:Bleeding Dermal vascular necrosis is early appearing adverse effect. Due to decreased osteocalcin synthesis Warfarin causes nasal hypoplasia and therefore contraindicated in pregnancy
Protein C deficiency
Sickle cell anemia
Factor V leiden deficiency
Antithrombin 3 deficiency
JIPMER 2017