Which of the following is not true about chromothrypsis?
Chromothrypsis Phenomenon by which up to thousands of clustered chromosomal rearrangements occur in a single event in localized and confined genomic regions Involved in cancer (1% -2%)and congenital diseases. Osteosarcomas and gliomas as well. Chromosome breaks occur within pa or across the entirety of a single chromosome or several chromosomes. Activate oncogenes and inactivate tumor suppressors, thereby expediting the process of carcinogenesis.
It is associated with chromosome rearrangements termed as chromosome shattering.
It is observed in 1% to 2% of cancers as a whole.
Associated with inactivation of oncogenes and activation of tumor suppressors.
Increased frequency of 25% of osteosarcomas and high frequency in gliomas
Miscellaneous