Multiple sclerosis is characterized by all EXCEPT -
i.e. (Oligodendrocytes): (884-Harsh Mohan 6th) (1310-1312-Robbins & Cotran 8th)MULTIPLE SCLEROSIS - is an autoimmune demyelinating disorder characterized by distinct episodes of neurologic deficits separated in time, attributable to white matter lesions that are separated in space*Pathologic hallmark is the presence of many scattered discrete areas of demyelination termed plaques**MORPHOLOGIC FEATURES*Grossly - plaque appears as grey-pink swollen sharply defined usually bilaterally symmetric areas in the white matter*Microscopically - according to the age of the plaque1. Inactive enlarging plaque, the histologic features are an accumulation of lymphocytes and macrophages around venules and at the plaque margin where demyelination is occurring. In addition, there is a loss of oligodendrocytes and presence of reactive astrocytes with numerous lipid-laden macrophages (microglia) in the plaque. The axons in the plaque are generally intact.2. In old inactive plaque - there is no perivascular inflammatory cell infiltrate and nearly total absence of oligodendrocytes. Demyelination in the plaque area is complete as there is an only limited regeneration of myelin gliosis is well developed but astrocytes are less prominent. Some axonal loss may be present.
Demyelination
Grey-tan plaques in the white matter
Increased protein concentration in CSF
Oligodendrocytes