Endogenous pyrogens act by ?
Ans. is 'b' i.e., Raising thermostat point of hypothalamusBacterial toxins (exogenous pyrogens) stimulate inflammatory cells to secrete pyrogenic cytokines (endogenous pyrogens), e.g. IL-I, TNF-a , and IL-6.These endogenous pyrogenes stimulate PGE2 release in hypothalamus, which raises temperature set point of hypothalamus to cause fever.
Increasing heat generation
Raising thermostat point of hypothalamus
Causing vasoconstriction
By Non-shivering thermogenesis