Integrin is associated with all Except
The rolling leukocytes are able to sense changes in the endothelium that initiate the next step in the reaction of leukocytes, which is firm adhesion to endothelial sur- faces. This adhesion is mediated by integrins expressed on leukocyte cell surfaces interacting with their ligands on endothelial cells (Fig. 2-5 and Table 2-2). Integrins are transmembrane heterodimeric glycoproteins that mediate the adhesion of leukocytes to endothelium and of various cells to the extracellular matrix. They are normally expressed on leukocyte plasma membranes in a low- affinity form and do not adhere to their specific ligands until the leukocytes are activated by chemokines. Integrins and Integrin Ligands ICAM-1 (immunoglobulin family) CD11/CD18 integrins (LFA-1, Mac-1) Firm adhesion, arrest, transmigration VCAM-1 (immunoglobulin family) VLA-4 integrin Adhesion Ref Robbins 9/e p35_36
Rolling
Adhesion
Arrest
Transmigration
General pathology