Causes of severe hypokalemic metabolic alkalosis with severe hypeension include
Liddle syndrome - AD, gain-in-function mutations of ENaC subunits. Activating kidneys to excrete potassium retaining excessive sodium & water, leading to hypeension. C/F- severe hypeension with hypokalemia, unresponsive to spironolactone yet sensitive to amiloride
Liddle syndrome
Bater syndrome
Gitelman syndrome
Renal tubular acidosis
Bater syndrome, Gitelman syndrome, Liddle and Comparison with SIADH