Retinoblastoma –
Rosettes are feature of well differentiated retinoblastoma, therefore suggest the good prognosis.
Hereditary retinoblastoma accounts for 40% of cases and the gene is located at 13q14 chromosome.
Prognosis is fair with 70-85% survival rate if the eyeball is enucleated before the occurrence of extra ocular extension.
Is inherited in 50% of cases
Is caused by deletion of 11q14
Rosettes suggest good prognosis
Causes death in 60% of sufferers in the UK