MAC of the volatile agent is reduced in all of the following except
Hypernatremia causes CNS excitation thus increases MAC. Pregnancy decreases MAC because there is increase in progesterone level in pregnancy. progesterone has sedative effect on brain. age decreases MAC by 6%/decade Acute alchohol intoxication produce sedation thus decreases MAC
Elderly
Acute alcoholic intoxication
Pregnancy
Hypernatremia
Inhalational Anesthetic Agents