Imipeneme is active against which of the following organism/s?
Ans. is 'd' i.e., All the above Imipenem* A derivative of thienamycin,imipenem is an extremely potent and broad spectrum b-lactam antibiotic whose range of activity includes gram-positive cocci, Enterobacteriaceae, Ps. aeruginosa, Listeria as well as anaerobes like Bact. fragilis and Cl.difficile.* It is resistant to most b-lactamases; inhibits penicillinase producing staphylococci.* Though some MRSA are inhibited, it is not reliable for treating such infections.* A limiting feature of imipenem is its rapid hydrolysis by the enzyme dehydropeptidase Ilocated on the brush border of renal tubular cells.* An innovative solution to this problem is its combination with cilastatin, a reversible inhibitor of dehydropeptidase I, which has matched pharma cokinetics with imipenem (tl/2 of both isl hr) and protects it.* Imipenem-cilastatin 0.5 g i.v. 6 hourly (max4 g/day) has proved effective in a wide range of serious hospital- acquired respiratory, urinary,abdominal, pelvic, skin and soft tissue infections including those in neutropenic, cancer and AIDS patients. For Ps. aeruginosa infections, it should be combined with gentamicin.
Gram positive cocci
B. fragilis
CL difficle
All the above
Anti Microbial