Which of the following is not true about Xenon anesthesia?
Ans. c. Slow induction and slow recovery Xenon anaesthesia is inert, non-explosive, environment friendly having low blood solubility with minimal cardiovascular side effects. Lower blood gas coefficient of Xenon results in rapid induction and recovery.Xenon Anesthesia* Xenon was isolated by William Ramsay (Nobel prize for chemistry ) in 1904 and 1st used as anesthetic in 1950.* It is one of the noble gases (colourless, odurless, nonirritating, non-flammable, does not support combustion and non-explosive gas)* Heavier than air (4 times) and more viscous than N2 and N2O.* Being extremely unreactive. it does not interact with soda lime, but will diffuse readily through rubber.* Except for cost, xenon would be the most ideal inhaled anesthetic agent because Xenon (MAC of 71%) is more potent than nitrous oxide, can provide anesthesia in 30% O2 is very insoluble (blood-gas partition coefficienct of 0.14) and has positive medical and environmental effects.Characteristic Features of Xenon Anaesthesia* Minimal cardiovascular and hemodynamic side effects* Not known to be metabolized in liver or kidney* Not teratogenic and does not trigger malignant hyperthermia* Neuroprotective and cardioprotective0* Emergence from xenon anesthesia is faster* Xenon is more potent than nitrous oxide with MAC 71%* It is a good analgesic* Blood-gas solubility coefficient of less than one third of N2O, there is still the potential of diffusion hypoxia during recovery.* Lower blood gas coefficient of Xenon results in rapid induction and recovery* It provides good hemodynamic stability with little change in blood pressure.* It inhibits calcium pump in plasma membrane0 and NMDA receptor in dorsal bom neuron.Advantages of Xenon AnesthesiaDisadvantages of Xenon Anesthesia* Inert, non-explosive, environment friendly* Low blood solubility* Not metabolized in the body* Rapid induction and recovery* Eliminated via lungs (can be used in renal and hepatic failure)* Does not trigger malignant hyperthermia* High cost* Less potent* No commercially available anesthesia equipment
Non explosive
Minimal cardiovascular side effects
Slow induction and slow recovery
Low blood gas solubility
Miscellaneous General Anesthesia