Which of the following substances is primarily found in tendons?
Ans. is 'a' i.e., Collagen o Tendon is primarily made up of collagen.o Main component of connective tissue. Most abundant protein in mammals.Major collagen typesTypeTissue distributionIIIIIIVBone, dermis, tendon, ligament corneaCartilage, vitreous body, nucleus pulposusSkin, vessel wall, reticular fibres of most tissues (lung, liver, spleen etc)Lung, cornea, bone, fetal membranes together with type I collagenSome key points about collageno Protein makes up about 20% of the body's mass and collagen makes up around 30% of the protein in the human body.o There are at least 16 types of collagen but 80-90% of collagen in the body consists of type I, II and III.Characterizations of collageno The various isoforms are the most abundant proteins in the animal kingdomo There are at least 16 types (or 24 types)o Types I, II and III are the most abundant and form fibrilso Type IV forms sheets (found in the basal lamina)o They form triple heliceso They have unique segments that interrupt the triple helix and are responsible for the unique properties of individual collageno They contain a three residue repeat of: glycine, proline, Xo They are rich n hydroxyprolineo There are three amino acids per turn of the helix, with pyrrolidone rings on the outside of the helixo The helix is stabilized by hydrogen bondso The fibrous backbone of the extracellular matrix
Collagen
Fibrin
Fibrillin
Protedglycans
Disorder of Metabolism & Connective Tissue