Treatment of hypeensive crisis in pheochromocytoma
Ref:KD Tripathi 7thE pg: 565 Phentolamine is used for pheochromocytoma. Note Non selective alfa-blockers cause fall in t.p.r, which is compensated by increased HR and C.O. So, they are not used routinely for htn. They block both alfa-1 and alfa-2 receptors- NA release is accentuated. Reserved for special situations like pheochromocytoma, clonidine withdrawal, cheese reaction, where circulating CA&;s are responsible for the rise in BP.
Phentolamine
Hydralazine
Guanethidine
Salameterol
Endocrinology and breast