Mech of action of bevacizumab
Bevacizumab:- Mech of action:- It is a humanized monoclonal antibody that binds VEGF-A and hinders its access to the VEGF receptor, interrupting angiogenic signalling. Uses:- combined with 5-FU, bevacizumab is used in metastatic colorectal cancer. Added to conventional chemotherapy, it improves survival in metastatic non-small cell lung cancer, breast cancer, clear cell renal carcinoma and glioblastoma. Deafness due to neurofibromatosis can be reversed by growth inhibitory effect of bevacizumab. Ref:- kd tripathi; pg num:-871
Inhibitor of HER-2/Neu
Inhibitor of VEGF
Inhibitor of c-kit
None of the above
Chemotherapy