A 60 yr old lady is concerned about the wrinkles around her eyes.This is due to defect in
Collagen cross-linking: Cross linking occurs when a protein linked to other protein,lipid or sugar which is necessary for normal collagen function. Abnormal cross linking causes wrinkles/ages skin which is due to glucose mediated advance glycation end products(AGE),UV mediated free radical damage. Collagenase: Defect in collagen leads to increased level of collagen Collagenase inhibitor are given to treat wrinkles Desmosine: Desmosine is formed by 3allsyl side chains and one unaltered lysyl side chain of elastin. Fibrillin: It is a glycoprotein secreted by fibroblasts. It forms a framework of elastin deposition Defect in fibrillin-1 results in Marfans syndrome Reference: Harpers illustrated biochemistry 30th edition
Collagenase
Desmosine
Fibrillin
collagen cross linking
General anatomy