A patient with recurrent bacterial infections is diagnosed to have a genetic deficiency in myeloperoxidase. The cause of increased susceptibility to infections is -
Ans. is 'c' i.e., An inability to produce hydroxyhalide redicalso Myeloperoxidase in the presence of halide (C1 ) conves H202 to hypochlorite (HOCI). HOCI is a potent microbicidal agent that destroys microbes by halogenation or by oxidation of lipids and proteins. The H202 myeloperoxidase halide system is the most efficient bactericidal system in neutrophils.
Defective neutrophil degranulation
Defective production of prostaglandins
An inability to produce hydroxyhalide radicals
Decreased oxygen consumption after phagocytosis