Neostigmine antagonizes nondepolarizing blockade by all of the following mechanisms, except ?
Ans. is 'c' i.e., Increasing the release of Acetylcholine at the motor end palate o Anticholinestrases act by inhibiting the action of acetylcholinesterase (an enzyme that degrades acetylcholine by causing its hydrolysis). o Anticholinesterases thus increase the level of acetylcholine at the neuromuscular junction. o Neostigmine also has some additional direct action on cholinergic receptors i.e., it depolarizes motor end plate. o It does not increase the release of ACH. Accumulated ACH acts on prejunctional muscarinic autoreceptors and inhibits the release of ACH.
Decreasing the breakdown of Acetylcholine at the motor end plate
Preventing K+ efflux from the cell
Increasing the release of Acetylcholine at the motor end plate
Depolarization of the motor end plate