A patient was taking warfarin and INR comes out to be 8. Next step would be to stop the drug and:-
Management of warfarin overdose is done as follows: *INR < 5 but above therapeutic range - Discontinue warfarin temporarily and resta at low dose. *INR 5-9 - Vitamin K1 (1 mg oral) *INR > 9 but no bleeding - Vitamin K1 (2 - 3 mg oral) *INR > 20 or bleeding - Four factor prothrombin complex or Fresh frozen plasma.
Resta at a lower dose once the INR is in therapeutic range
Give oral vitamin K1
Administer fresh frozen plasma
Transfuse fresh blood
Hematology