Which characteristic feature is seen in the kidney in Malignant hypeension -
Ans. is 'c' i.e., Fibrinoid necrosiso Malignant nephrosclerosis is the form of renal disease associated with malignant or accelerated phase of hypeension.Pathology of kidney in Malignant Hypeension On Gross Inspection :o The kidneys are normal in size or slightly enlarged. They have a smooth surface with numerous small petechial hemorrhages.o These small pinpoint petechial hemorrhages appear on the coical surface from rupture of aerioles or glomerular capillaries.On Histology ?Two distinct vascular lesions are seen(i) Fibrinoid necrosiso It affects the aerioles and is characterized by infiltration of aeriolar walls with eosinophilic material including fibrin, thickening of vessel walls and occasionally, an inflammatory infiltrate (necrotizing aeriolitis).(ii) Hyperplastic aeriolitiso This affects the interlobular aeries and aerioles.o There is concentric hyperplastic proliferation of the smooth muscles together with fine concentric layering of collagen to form a hyperplastic aeriolitis (Onion skin lesion).
Hyaline necrosis
Fibrinoid necrosis
Medial wall hyperplasia
Medial wall hyperplasia