Which antibody is a/w the condition showing following features?
Systemic Sclerosis (Scleroderma) Characterized by vascular injury and progressive perivascular and interstitial fibrosis of multiple organs. Females>Males with age group is 30 to 50 years. Cutaneous involvement is most common. Etiology and pathogenesis Microvascular injury is a hallmark feature of systemic sclerosis. Two clinical categories are: Diffuse scleroderma: Widespead cutaneous involvement. It has two Auto-antibodies: Anti-topoisomerase I (anti-Scl-70) antibodies are specific. RNA polymerase III antibodies.
Anti ds. DNA
Anti-Ro
Anti CCP
Anti SCL - 70
Other Autoimmune Disorders