Which insulin has the late onset of action, longer duration of action, and has no pronounced peak?
Insulin glargine is a soluble, "peakless" (ie, having a broad plasma concentration plateau), long-acting insulin analog. This product was designed to provide reproducible, convenient, background insulin replacement.Insulin glargine has a slow onset of action (1-1.5 hours) and achieves a maximum effect after 4-6 hours. This maximum activity is maintained for 11-24 hours or longer. Glargine is usually given once daily, although some very insulin-sensitive or insulin-resistant individuals benefit from split (twice a day) dosing.Reference: Katzung Pharmacology; 13th edition; Chapter 41; Pancreatic Hormones & Antidiabetic Drugs
NPH
Glulisine
Glargine
Aspa
Endocrinology