Chromophobe variant of renal cell is associated with -
These tumors are unique in having multiple losses of entire chromosomes, including chromosomes 1, 2, 6, 10, 13, 17, and 21. Thus, they show extreme hypodiploidy. Because of multiple losses, the "critical hit" has not been determined. Ref: Robbins basic pathology 9th edition page548
VHL gene mutations
Trisomy of 7 and 17 (+7, +17)
3 p deletions (3p-)
Monosomy of 1 and Y (-1, -Y)
Urinary tract