Fibroblast proliferation is stimulated by?
“TFG-β is practically always involved as an important fibrogenic agent” - Robbins
• The most important fibrogenic mediator (causing fibrosis) is transforming growth factor- β. It induces the proliferation of fibroblasts, endothelial cells and specialized fibrogenic cells. It is chemotactic for fibroblasts, neutrophils, macrophages, lymphocytes and smooth muscle cells.
TGF-β
IFN-γ
TNF-α
IL-10