Drug used in irritable bowel syndrome with constipation is?
Lubiprostone acts by stimulating cl- channel opening in the intestine increasing liquid secretion in the gut and decresing transit time therefore used for chronic constipation. It has also been approved for constipation dominant irritable bowel syndrome in women.( ref katzung 11/e p1080)
Lubiprostone
Loperamide
Alosetrone
Clonidine
Gastrointestinal tract