Number of ATP molecules and NADPH formed in each cycle of glycolysis In aerobic condition,
when oxygen is in plenty, the two NADH molecules, generated in the glyceraldehyde3-phosphate dehydrogenase reaction (step 5), can enter the mitochondrial electron transpo chain for complete oxidation. As each NADH provides 2.5 ATPs, this reaction generates 2.5 x 2 = 5 ATPs. Thus when oxygen is available, the net gain of energy from the glycolysis pathway is 7 ATPs. In aerobic conditions, Pyruvate is later oxidatively decarboxylated to acetyl CoA which enters the citric acid cycle for complete oxidation. Complete oxidation of glucose through glycolysis plus citric acid cycle will yield a net 32 ATPs. Ref: DM VASUDEVAN TEXTBOOK OF BIOCHEMISTRY,EIGHTH EDITION,PG.NO.,132.
4,2
2,2
4,4
2,4
Metabolism of carbohydrate