Why oxygen transpo by haemoglobin is impaired by decreased glycolytic activity?
2,3 bisphosphoglycerate is an impoant allosteric modifier of haemoglobin oxygen saturation and desaturation. During decreased glycolytic activity decreased production of 2,3 bisphosphoglycerate is responsible for increased oxygen affinity for Hb and decreased dissociation from it leading to impaired oxygen delivery to tissues.
Reduced synthesis of haemoglobin
Reduced energy production
Increased production of 2,3 bisphosphoglycerate
Decreased production of 2,3 bisphosphoglycerate