What instruction do you give to a mother who is lactating regarding intake of drug?
ANS. DPlasma concentration of drug varies with time follows the graph as shown below. Certain drugs can be secreted in breast milk and therefore transferred to the infant. Care should be taken to decrease this to the minimum possible levels.Least plasma concentration of the drug will be just before the next loading dose. Hence, the least chance for the drug to be concentrated in milk and thereby transferred to the infant would be at the time just before taking next dose. Hence advice mother to lactate just before taking next dosage of the drug.
No advice as most of drug are not secreted into breast milk
Give longer half-life drugs
Tell the mother to feed when it is least efficacious
Lactate Just before she take the next dose, when the plasma concentration of drug would be least.
General Pharmacology