Primary biliary cirrhosis is most commonly associated with______
Primary Biliary Cirrhosis Autoimmune disorder Clinical manifestation - obstructive jaundice F > M Antibody seen in antimitochondrial ab which is formed against E2 subunit of PDH enzyme. Interlobular bile ducts are actively destroyed by lymphoplasmacytic inflammation with or without granulomas.
Systemic sclerosis
Sjogren syndrome
Ulcerative colitis
Pancreatitis
Bilirubin Metabolism