Pick the false statement about pattern recognition receptors out of the following:
The best known of the pattern recognition receptors are the Toll-like receptors (TLRs). The TLRs are present in the plasma membrane and endosomal vesicles. Act by activation of:- NF-kB Interferon regulatory factors (IRFs) -NOD-like receptors (NLRs) are cytosolic receptors. They recognize products of necrotic cells, ion disturbances, and some microbial products. Several of the NLRs signal a cytosolic multiprotein complex called the inflammasome, which activates an enzyme (caspase-1) that cleaves a precursor form of the cytokine interleukin-1 (IL-1) to generate the biologically active form. IL-1 recruits leukocytes and induces fever. Gain-of-function mutations in one of the NLRs result in periodic fever syndromes, called autoinflammatory syndromes.
Toll like receptors are best known of the pattern recognition receptors
Toll like receptors are present in the plasma membrane and act by activation of NF-kB and interferon regulatory factor
NOD-like receptors (NLRs) are cytosolic receptors whose mutations lead to autoimmune disorders
RIG-like receptors (RLRs) are located in the cytosol and stimulate the production of antiviral cytokines
Basic Concepts