Long term use of aspirin in rheumatoid ahritis is limited by its propensity to cause:
All non-selective COX inhibitors including aspirin on long-term used can cause gastric toxicity ranging from gastritis to peptic ulcer. Selective COX-2 inhibitors have lesser propensity to cause this adverse effect. Salicylism and metabolic acidosis are seen in overdose, not with long term use.
Metabolic acidosis
Hypersensitivity reactions
Gastric mucosal damage
Salicylism
NSAIDs, Gout and Rheumatoid Ahritis