GnRH agonist is used in all EXCEPT
(C) Hypoestrogenism# Gonadotropin-Releasing Hormone Agonist (GnRH agonist, GnRH-A) is a synthetic peptide modeled after the hypothalamic neurohormone GnRH that interacts with the gonadotropin-releasing hormone receptor to elicit its biologic response, the release of the pituitary hormones FSH and LH.# H agonists are useful in:> Suppression of spontaneous ovulation as part of controlled ovarian hyperstimulation, which is an essential component in in vitro fertilisation (IVF).> Typically, after GnRH agonists have induced a state of hypoestrogenism, exogenous FSH is given to stimulate ovarian follicle, followed by human chorionic gonadotropins (hCG) to trigger oocyte release.> GnRH agonists routinely used for this purpose are: buserelin, leuprorelin, nafarelin, and triptorelin.> Final maturation induction after having performed controlled ovarian hyperstimulation.> Usage of GnRH agonist for this purpose necessitates using a GnRH antagonist instead of a GnRH agonist for suppression of spontaneous ovulation, because using GnRH agonist for that purpose as well inactivates the axis for which it is intended to work for final maturation induction.> Treatment of cancers that are hormonally sensitive and where a hypogonadal state decreases the chances of a recurrence. Thus they are commonly employed in the medical management of prostate cancer and have been used in patients with breast cancer.> Treatment of delaying puberty in individuals with precocious puberty.> Delaying puberty pending treatment decisions in children with gender incongruency> Management of female disorders that are dependent on estrogen productions.> Women with menorrhagia, endometriosis, adenomyosis, or uterine fibroids may receive GnRH agonists to suppress ovarian activity and induce a hypoestrogenic state.> Suppressing hormone levels in transsexual people, especially trans women.> Severe cases of congenital adrenal hyperplasia> Side effects of the GnRH agonists are signs and symptoms of Hypoestrogenism, including hot flushes, headaches, and osteoporosis.
Delaying puberty in individuals with precocious puberty
Endometriosis
Hypoestrogenism
Congenital adrenal hyperplasia
Miscellaneous (Gynae)