All of the following are true about gastrinoma except:
Gastrinoma OR Zollinger-Ellison syndrome (ZES) Increased gastrin, increased acid, increased risk of peptic ulcer disease. Triangle of Passaro/ Gastrinoma Triangle. M.C site of gastrinoma is duodenum (1st, 2nd& 3rd)> pancreas Gastrinoma is associated with MEN-1 syndrome. Diagnosis Basal acid output > 15 mEq / hour Best provocative test - Secretin Stimulation Test (gastrin release > 200Pg/ ml) IOC for localization - Somatostatin Receptor Scintigraphy Drug of choice - PPI Treatment of choice: pylorus preserving pancreatoduodenectomy
Mostly found in triangle of Passaro
Basal acid output >15 mEq/hour is diagnostic
Most common site is pancreas
Lymphadenectomy is not required as there is no improvement in survival
Pancreas