Which of the following is the most effective drug against M. leprae ?
Rifampicin is the only bactericidal drug amongst the anti leprosy drugs & can render Leprosy rapidly non contagious. It acts by inhibiting mycobacterial DNA dependent RNA synthesis. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Pages 700, 709-11, 713.
Dapsone
Rifampicin
Clofazamine
Prothionamide