Which of the following is ultrastructural feature of irreversible cell injury? September 2010
Ans. B: Formation of amorphous densities in the mitochondrial matrixIrreversible cell injuryAfter the initiation of irreversible death, the cell and its organelles sta to disintegrate, leading to rupture of the cells.Gradually, the cytotoxic edema stas to resolve and interstitial edema develops as the cell membranes disintegrate and the intracellular components become extracellular.This results in increased Brownian water motion and marked reduction in diffusion restriction.The neuronal death result in reduction of its markers (NAA)
Formation of phagolysosomes
Formation of amorphous densities in the mitochondrial matrix
Formation of blebs in plasma membrane
Detachment of ribosomes from rough