Zero-order kinetics occur in the following drug with high dose
zero order kinetics -the rate of elimination remains constant irrespective of drug concentration, clearance decreases with increase in concentration, or a constant amount of drug is eliminated in unit time The elimination of some drugs changes from first order to zero order at higher doses eg ; Phenytoin, Tolbutamide, Theophylline, Warfarin, DIGOXIN, aspirin ref; KD Tripathi Pharmacology 7th edition (page no;31 )
Phenytoin and Theophylline
Digoxin and Propranol
Amiloride and Probenecid
Lithium and Theophylline
General pharmacology