Which is not a characteristic of wegeners granulomatosis?
Wegener granulomatosis is a necrotizing vasculitis characterizedby a specific triad of findings:* Granulomas of the lung and/or the upper respiratorytract (ear, nose, sinuses, throat)* Vasculitis of small to medium-sized vessels (capillaries,venules, aerioles, and aeries), most prominently inthe lungs and upper respiratory tract* GlomerulonephritisWegener granulomatosis is likely to be initiated as acell-mediated hypersensitivity response directed againstinhaled infectious or environmental antigens. PR3-ANCAsare present in almost 95% of cases and probably drive thesubsequent tissue injury.(Robbins basic pathology,9th edition,pg no.353)
Granuloma in vessel wall
Focal necrotising glomerulonephritis
Positive for cANCA
Involves large vessels
Cardiovascular system