True about Atosiban:
Ans. a (is an oxytocin receptor antagonist). (Ref. KDT, Pharmacology, 6th ed., p 323)ATOSIBAN# Atosiban is an oxytocin receptor antagonist with high uterine specificity.# It is effective in inhibiting preterm uterine contractions, and is at least as effective as conventional beta-agonist therapy in treating preterm labour, but with significantly fewer maternal and fetal side effects.# The incidence of maternal/fetal side effects is significantly higher with beta-agonists, and serious maternal CV side effects, such as pulmonary edema and myocardial ischemia, were also associated with beta-agonist but not atosiban therapy.# The favourable safety profile of atosiban in combination with equivalent tocolytic effectiveness would appear to represent an advance over current tocolytic therapy. Sr .no.Tocolytic Agents Comments1IsosuprineS/E--hypotension, pulmonary edema, ARDS, hypokalaemia, hyperglycemia.2RitodrineS/E-hypotension, pulmonary edema, ARDS, hypokalemia, hyperglycemiaQ3Salbutamol-4Ethanol-5MgSO4 (UP 2002)- Monitor respiration, urine output and deep reflexes.- Antidote is calcium gluconate.- Therapeutic levels = 4-7 mEq/L6AspirinProstaglandin inhibitor7Nifedipine-8AtosibanOxytocin analogue,oxytocin receptor antagonist - Counteracts effects of endogenous oxytocin.9Sodium nitroprussideNitric oxide donor, increases cGMPQ10Potassium channel opener
is an oxytocin receptor antagonist
is an progesterone receptor antagonist
is least effective in inhibiting preterm uterine contractions
is a anti-tocolytic drug
Pregnancy