Acetylcholine is not used commersially because:
[Cl (Rapidly destroyed in the body): Ref: 80KDT,435-BB (93-KDT 6th)Acetylcholine is not used because of evanescent and nonselective action* Acetylcholine injected IV. Does not penetrate blood brain barrier and no central effects are seen.* Acetylcholine has such great importance in the body it is not surprising that attempts have been made to use it in therapeutics, But a substance with a huge variety of effects and so rapidly destroyed in the body is unlikely to be useful when given systemically, as its history in psychiatry illustrates.
Long duration of action
Costly
Rapidly destroyed in the body
Crosses blood brain barrier
A.N.S.