Tubocurare affects which muscle first?
Sequence of blockade : face - jaw- pharynx - larynx - respiratory (including diaphragm) - trunk muscle - limb muscle. Face muscles are involved earliest. 1)in non-depolarising blocker (d-Tc), earliest clinical sign is Ptosis and diploia 2)In succinylcholine (depolarising blocker ),First clinical sign is Fasciculation of eye lids.
Head and neck
Limbs
Respiratory muscles
Abdominal muscles
Muscle relaxants