Vitamin B12 and folic acid supplementation in megaloblastic anemia leads to the improvement of anemia due to
Deficiency of folic acid Reduced DNA Synthesis because THF derivatives are involved in purine synthesis and thymidylate Synthesis Megaloblastic Anemia Vitamin B12 deficiency and Folate deficiency can lead to this condition In Vitamin B12 deficiency Megaloblastic anemia is due to folate trap ref DM Vasudevan 8th ed page 476
Increased DNA synthesis in bone marrow
Increased hemoglobin production
Erythroid hyperplasia
Increased iron absorption
vitamins