More than 90% of this drug is excreted in the urine in intact form. Because it's urinary solubility is low, patient should be well hydrated to prevent nephrotoxicity. The drug is:
(Ref: Katzung 10/e p793; KDT 6/e 769) Both indinavir and acyclovir can cause nephrotoxicity bad renal stone formation. But indinavir is metabolized mainly in the liver and acyclovir is excreted unchanged in the urine.
Indinavir
Zidovudine
Acyclovir
Amantadine
Other topics and Adverse effects