All of the following statements are true regarding carbimazole as compared to propylthiouracil except?
Propylthiouracil has less transfer across placenta, so is preferred in first trimester of pregnancy. Propey Carbimazole PTU Potency Plasma half life Frequency of dosing Plasma protein binding Transfer across placenta Peripheral conversion Hepatotoxicity High More Once a day High High No effect Absent Low Less Thrice a day Low Low Inhibits Present
Carbimazole cross placenta less than propylthiouracil
Carbimazole is more potent than propylthiouracil
Carbimazole can be used as single daily dose whereas propylthiouracil needs to given thrice a day
Carbimazole does not inhibit peripheral conversion of T4 to T3
Pituitary-Hypothalmic System and Thyroid