In Wilm's tumor the following leads to emergence of resistance to chemotherapy:
Wilm's tumor : 5% of tumors reveal anaplasia- Large, hyperchromatic, pleomorphic nuclei and abnormal mitoses . The presence of anaplasia correlates with underlying p53 mutation -Emergence of resistance to chemotherapy.
Nephrogenic rests
Monophasic morphology
Anaplasia
Capsular infiltration
Wilms Tumor