Mechanism of action of actinomycin D is -
Ans. is 'a' i.e.. Inhibits DNA dependent RNA synthesis The anticancer antibiotics are :o Actinomycin - D (Dactinomycin)o Daunorubicin (Rubidomycin)o Mitomycin C* Doxorubicino Mitoxantroneo Mithramycin (plicamvcin)o Bleomycins o These anticancer, antibiotics obtained from micro-organisms and have prominent antitumour activity,o Mechanism of action : They are intercalated betw een DNA strands and interfere w ith its template functionActinomycin "D' inhibits DNA dependent RNA synthesis.Bleomycin cause DNA breakage and free radical formation .Doxo-and daunorubicin inhibit Topoisomerase I & II.Mitomycin acts like alkylating agents.Mitoxantrane binds to DNA to produce strand breakage and inhibits both DNA & RNA synthesis.RememberAll antitumor antibiotics are cell cycle nonspecific except for bleomycin which acts in G2 phase.
Inhibits DNA dependent RNA synthesis
Activates DNA dependent RNA synthesis
Inhibits RNA dependent DNA synthesis
Activates RNA dependent DNA synthesis
Anti-Neoplastic Agents