A patient comes to you complaining that whenever he takes aspirin for headache, he develops severe shoness of breath. Which of the following may be paly responsible for this effect?
Aspirin inhibits COX enzyme and results in the diversion of AA pathwaytowards LT synthesis. As LTs are powerful bronchoconstrictor agents, these may result in the shoness of breath in patients who are susceptible. Aspirin acetylated COX stas producing lipoxins (known as aspirin triggered lipoxins) that also have bronchoconstrictor propeies.
Leukotrienes
Prostaglandin E
Thromboxane A2
Prostacyclin
NSAIDs, Gout and Rheumatoid Ahritis