In hypogonadotropic hypogonadism?
- LH and FSH are decreased in hypogonadotropic hypogonadism. Hypogonadotropic hypogonadism: - Reversible - if its d/t to Chronic systemic illness (CKD, Chronic liver Disease) Severe malnutrition Endocrine causes (hypothyroidism, type 1 DM) - Permanent if its d/t Isolated delayed pubey - Genetic mutations - KAL 1 (Kallmann Syndrome), GnRH Receptor, DAX -1 gene - Syndromes- Prader Willi Syndrome, Laurence Moon Syndrome MPHD (multiple pituitary hormone disease) - Injury - Infiltration by tumors- Langerhan cell histiocytosis - Genetic - PROP1,LH - Malformations - Trauma
Both LH and FSH decreased
Both LH and FSH increased
LH increased and FSH decreased
LH decreased and FSH increased
Disorders of Pubey