Which of the following statements about fluconazole is most accurate?
* Fluconazole (Azoles) act by inhibiting the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. * It has very good CNS penetration and oral bioavailability. * It is not very effective against aspergillosis (voriconazole is the drug of choice).
It is highly effective in the treatment of aspergillosis
It does not penetrate the blood-brain barrier
Its oral bioavailability is less than that of ketoconazole
It inhibits demethylation of lanosterol
Anti-Fungal Drugs