A 72-year-old man is recently found to have hypocalcemia and Osteomalacia is suspected based on the decrease in the cortical bone thickness and osteopenia seen on x-rays. Which of the following is the most likely mechanism of the resistance to the effects of vitamin D?
Deficient or defective 1,25(OH)2 vitamin D receptors will result in vitamin D resistance. Parathyroid hormone levels increase secondary to decreased vitamin D effect. The 1(OH) vitamin D is an intermediate metabolite.
excess parathyroid hormone secretion
insufficient parathyroid hormone secretion
defective receptors for 25(OH) vitamin D
defective receptors for 1,25OH2 vitamin D
Immunology and Rheumatology