Iridocorneal endothelial syndrome is associated with:
IRIDOCORNEAL ENDOTHELIAL (ICE) SYNDROME (Aka. ESSENTIAL IRIS ATROPHY, CHANDLER SYNDROME, COGAN REESE-SYNDROME & IRIS NEVUS SYNDROME) This rare idiopathic condition of young adults is usually unilateral and manifested by corneal decompensation, glaucoma, and iris abnormalities (corectopia and polycoria). It is unilateral, progressive, relatively uncommon and non-familial condition in young adults. It is associated with glaucoma due to the obstruction caused. The etiology of the condition is unknown. Ref: Roy and Fraunfelder's current ocular therapy, Frederick Hampton Roy, F. Frederick W. Fraunfelder, Frederick T. Fraunfelder, Elsevier Health Sciences, 2007.
Progressive atrophy of iris stroma
Bilateral stromal edema of iris & cornea
Deposition of collagen in Descemet's membrane
Deposition of glycosaminoglycan in Descemet's membrane