True statement regarding Barrett's esophagus: September 2011
Ans. D: Metaplastic change in the lining mucosa of the esophagusBarrett's esophagus is a metaplastic change in the lining mucosa of the esophagus in response to chronic gastro-esophageal refluxEsophageal cancer:Impoant predisposing factors:- Excess alcohol- Smoking- Chronic achalasia- Tylosis- Barrett's esophagus- Plummer Vinson syndromeFeatures:- Progressive dysphagia (MC)- Weight loss- WeaknessEsophagoscopy is diagnosticChemotherapy:- Limited role- Cisplatin- Bleomycin- 5-FluorouracilMC type: Squamous cell CaMC site: Lower endMC site of adenoCa: Lower end.MC site of squamous cell Ca: Middle third
Patient present with severe symptoms
Normal pH profile
Increased risk of squamous cell carcinoma
Metaplastic change in the lining mucosa of the esophagus