All of the following are genetic motor neuron diseases affecting predominantly lower motor neurons except
Spinal muscular atrophy, Sandhoff's disease, Adult tay sachs disease are genetic motor neuron disease affecting lower motor neurons. Adrenoleukodystrophy is a genetic motor neuron disease affecting upper motor neurons. Ref Harrison 20th edition page 3144 , table 429-3
Spinal muscular atrophy
Sandhoff's disease
Adult tay sachs disease
Adrenoleukodystrophy
C.N.S