A 15 year old boy with epilepsy on treatment with combination of valproate and phenytoin has good control of seizures. Levels of both drugs are in the therapeutic range. All of the following adverse effects can be attributed to valproate except -
Ans. is 'd' i.e., Lymphadenopathy o Lymphadenopathy is due to phenytoin, not due to valproate. o Weight gain, hepatotoxicity (elevated serum alanine aminotransaminase) and hyperammonemia can be caused by valproate.
Weight gain of 5 kg
Serum alanine aminotransaminase 150 IU/L
Rise in serum ammonia level by 20 01
Lymphadenopathy