Features of hereditary spherocytosis include all of the following except :
Answer is C (MCV Ted) Mean corpuscular volume of RBC is decreased in patients with hereditary spherocytosis. Hereditary spherocytosis is characterised by defect in one of the proteins in the cytoskeleton of Red cell membrane, leading to loss of membrane, and hence decreased ratio of surface area to volume and consequently spherocytosis. Characteristic Laboratory abnormalities The mean corpuscular volume (MCV) : is decreasedQ The mean corpuscular Hb. concentration (MCHC) : is increasedQ Osmotic fragility is : increasedQ Remember the following also : * Most common membrane defect is that of Ankyrin Q * One characteristic clinical presentation is Striking splenomegaly Q * Treatment of choice is (anemia, splenomegaly, jaundice) Splenectomy Q
|Osmotic fragility
|MCHC
|mcv
Decrease surface area per unit volume .