Neutrophilic leukocytosis, lymphoenia, and eosinopenia are most likely associated with which of the following disorders?
Neutrophilic leukocytosis, lymphopenia, and eosino­penia are most likely associated with Cushing syn­drome and the hypercortisolism associated with the syndrome. Cortisol decreases neutrophil adhesion in the peripheral blood, thus releasing the marginating pool into the circulation. Cortisol also increases lym­phocyte adhesion in the efferent lymphatics and is toxic to eosinophils.
Endotoxic shock results in a neutropenia because endotoxins increase neutrophil adhesion. Absolute neutropenia is a feature of typhoid fever, splenomegaly, and sinus bradycardia. Whooping cough due to Bordetella pertussis produces an absolute lymphocyto­sis. Paroxysmal nocturnal hemoglobinuria, an ac­quired stem-cell disorder with increased sensitivity of hematopoietic cells to complement destruction, is as­sociated with aplastic anemia and pancytopenia.
Endotoxic shock
Typhoid fever
Whooping cough
Cushing syndrome