What is mechanism of action of colchicine in acute gout?
Ans. c. Binding to tubulin and inhibition of leucocyte migrationRef: Goodman Gilman 12th e/P 995Colchicine inhibits tubulins required for mobilization of leucocytes (neutrophils) in to joints in an acute attack of gout.It also inhibits release of chemotactic factors form neutrophils and inhibits adhesion of neutrophils to endothelium of blood vessels.
Inhibition of leukotriene B4
Inhibition of release of chemotactic factors
Binding to tubulin and inhibition of leucocyte migration
Promotes metabolism of urate crystal
Immunomodulator