True statement regarding development of drug resistance in MRSA is?
MRSA have emerged in many areas. These are insensitive to all penicillinase-resistant penicillins and to other beta-lactams as well as to erythromycin, aminoglycosides, tetracyclines, etc. The MRSA have altered PBPs which do not bind penicillins. ESSENTIALS OF MEFICAL PHARMACOLOGY page no 721
Results due to penicillinase enzyme production
Occurs due to change in penicillin blinding proteins
Chromosome mediated
Treated with amoxicillin + clavulanic acid
Chemotherapy