Arrange the steps in oncogenesis in the sequence: 1. increased activity of telomerase2. angiogenesis3. Evasion of host defense 4. Activation of proto-oncogene 5. Warburg effect
All cancers display eight fundamental changes in cell physiology, which are considered the hallmarks of cancer: * Self-sufficiency in growth signals* Insensitivity to growth-inhibitory signals* Altered cellular metabolism* Evasion of apoptosis* Limitless replicative potential (immoality)* Sustained angiogenesis* Invasion and metastasis* Evasion of immune surveillance
3-5-4-2-1
4-5-1-2-3
1-2-3-4-5
4-5-3-2-1
General Concepts