Chromosomal mutation in low grade transitional cell cancer of bladder is?
Ans. (c) FGFR3(Ref: Robbins 9th/968)*Noninvasive high-grade urothelial carcinoma is associated with loss of the TP53 and RB tumor suppressor genes while Noninvasive low-grade papillary urothelial carcinoma is associated with gain of function FGFR3 and HRAS mutations.
P53
Rb gene
FGFR3
HRAS
Kidney