Morphological features of celiac disease include all except:
- Distended macrophages with PAS positive granules in lamina propria is feature of Whipple's disease not celiac disease. - Remaining all features given in other options are features of celiac disease. CELIAC SPRUE: Associated with HLA- DQ2/ DQ8 Caused d/t intestinal immune reaction to gluten - Major storage protein of wheat & similar grains T-cells & antibodies like anti-tissue transglutaminase Ab, anti-gliadin Ab & anti-endomycial Ab are involved. Celiac disease. (A) Advanced cases of celiac disease show complete loss of villi, or total villous atrophy. Note the dense plasma cell infiltrates in the lamina propria. (B) Infiltration of the surface epithelium by T lymphocytes
Increase in intraepithelial lymphocytes
Increase in crypt: villous ratio
Distended macrophages with PAS positive granules in lamina propria
Elongated hyperplastic and touous crypts
Systemic Pathology