True statement about penicillin G is?
PnG is a narrow spectrum antibiotic; activity is limited primarily to gram-positive bacteria and few others. Penicillin G is acid labile-destroyed by gastric acid. As such, less than 1 /3rd of an oral dose is absorbed in the active form. Absorption of sod. PnG from i.m. site is rapid and complete; peak plasma level is attained in 30 min. Uses Penicillin G is the drug of choice for infection caused by organisms susceptible to it, unless tho: patient is allergic to this antibiotic. However, use has declined very much due to fear of causing anaphylaxis.Topical use of penicillin is highly sensitizing (contact dermatitis and other reactions). Therefore, all topical preparations of penicillin (including eye ointment) have been banned, except for use in eye as freshly prepared solution in case of gonococcal ophthalmia. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:696
It is administered orally
It has a wide spectrum
It can be used for rate bite fever
Co-administration of probenecid decreases its duration of action
Chemotherapy