True statement about p53 are all except
TP53 Transcription factor; Has propeies of both an oncogene and a tumour suppressor gene Small arm of Chr 17 (17p13.1) Protein product: p53 "Guardian of the genome"; "molecular policeman"; critical gatekeeper Li Fraumeni syndrome - Hereditary loss an allele Ca lung, colon, breast LOF mutation of TP53 - MC mutation in >50% cancers
It regulates ceain genes involved in cell cycle
Its increased levels can induce apoptosis
Its activity in cells decrease following UV radiation & stimulates cell cycle
Mutations in p53 are the MC genetic alterations seen in human cancer
General pathology