The following are related to bromocriptine therapy except:
Ans. is c, i.e. If pregnancy occurs, there is increased incidence of multiple pregnancyRef: Leon Speroff 7th/ed, p460-470Bromocriptine:It is a dopamine agonist, used in the management of galactorrhea.Peak of Bromocriptine occurs 1-3 hours after oral administration but very little remains in circulation after 14 hours.Pregnancy following bromocriptine has got no teratogenic effects on off spring.There is no increased incidence of multiple pregnancy.Side effect of bromocriptine: Giddiness, dizziness and postural hypotensionCabergoline: It is longer acting. A single dose of cabergoline can inhibit prolactin secretion for 7 days. Thus it has become DOC in case of hyperprolactinemia.A newer dopamine agonist licensed for treatment of hyperprolactinemia is Guinagolide (non ergot dopamine D, agonist).
It is used to inhibit inappropriate lactation with secondary amenorrhoea
It is specific in suppressing only the prolactin secretion
If pregnancy occurs, there is increased incidence of multiple pregnancy
Its teratogenic effect on the fetus is inconclusive
Disorders in Menstruation