Which of the following immunosuppressant drugs is most nephrotoxic?
Among the given drugs Tacrolimus has dose-limiting nephrotoxicity In addition, it can precipitate diabetes, alopecia, and diarrhea. Hypeension, hirsutism, gum hyperplasia is less marked compared to cyclosporin. Other drugs listed above are antiproliferative drugs. These have no excess nephrotoxicity effect. they act mainly by preventing the clonal expansion of T and B Lymphocytes. ESSENTIALS OF MEDICAL PHARMACOLOGY SEVENTH EDITION -K.D TRIPATHI Page:881,882 ,883
Azathioprine
Cyclophosphamide
Mycophenolate mofetil
Tacrolimus
Immunomodulators