Mechanism of action of furosemide as a diuretic is:-
Name Site of action Example Mechanism Loop diuretics Thick ascending limb of Loop of Henle Furosemide, Torsemide Na-K-2Cl sympoer inhibition Carbonic anhydrase inhibitors PCT Acetazolamide, Dorzolamide, Brinzolamide Carbonic anhydrase inhibition Thiazides DCT Hydrochlohiazide, Chlohalidone Na-Cl sympoer inhibition Osmotic diuretics Non-specific Mannitol By osmotic effect Epithelial sodium channel blockers Collecting duct Amiloride, Triamterene eNa channel blockade Aldosterone antagonists Collecting duct Spironolactone, Epleronone Antagonism of aldosterone receptors
Inhibition of Na-K-Cl ion sympoer
Aldosterone antagonism
Inhibition of Na-Cl sympoer in distal tubules
Carbonic anhydrase inhibition
Kidney