Which is the most appropriate definition of Spare receptors ?
Spare receptors : Receptors that are still left unoccupied , even with a concentration of agonist that produces maximal biological response. e.g Myocardial cells are said to contain a large propoion of spare b adrenoceptors.
The receptors which remain unoccupied even after drug produces maximal response
The receptors for binding of Inverse agonist
The receptors that produce adverse drug effects
The receptors that are unable produce maximum response
Pharmacodynamics