Neurofibrillary tangles are seen in?
ANSWER: (A) Alzheimer's diseaseREF: Harrison's Internal Medicine 17th ed> Chapter 365. DementiaAlzheimer's disease most often presents with subtle onset of memory loss followed by a slowly progressive dementia that has a course of several years. Pathologically, there is diffuse atrophy of the cerebral cortex with secondary enlargement of the ventricular system. Microscopically, there are neuritic plaques containing A amyloid, silver-staining neurofibrillary tangles (NFTs) in neuronal cytoplasm, and accumulation of A42 amyloid in arterial walls of cerebral blood vessels.NFT also seen in supra nuclear palsy
Alzheimer's disease
Lewy body disease
Neurosyphilis
Shy dragger syndrome
Neurodegenerative Diseases