All of the following statements about an alpha?glucosidase inhibitor are true except -
Ans. is 'c' i.e., Hypoglycemia is a serious and common side effect Alpha glucosidase inhibitors: acarbose: Miglital These are a class of oral glucose lowering agents that reduce postprandial hyperglycemia by delaying glucose absorption. o They are FDA approved for use in individuals with type -2 diabetes as monotherapy and in combination with sulfonylureas Katzung 101)Ve - 700 o These agents are unique as they reduce post prandial glucose rise even in individuals with type -I diabetes mellitus. Adverse effects: Major adverse effects include flatulence, diarrhea and abdominal distension/pain: This results from appearance of undigested carbohydrates in the colon that is then fermented into sho chain fatty acids releasing gas. Hypoglycemia: Not a problem with monotherapy May occur with concurrent use sulfonylureas.
Reduces intestinal absorption of carbohydrates
Effective in both type 1 & 2 diabetes
Hypoglycemia is a common & serious side effect
Can be used with other oral Hypoglycemic Agents