Patient complaints of muscle weakness. It was rivers on administration of neostigmine because
(Ref: Katzung 11/e p105) Neostigmine acts by inhibiting the enzyme acetylcholinesterase. This enzyme is involved in degradation of ACh,consequently neostigmine inereases the synaptic level of ACh. Muscle weakness can be improved by stimulation of NM receptors at muscle end plate due to increased ACh.
It blocks action of acetylcholine
It interferes with the action of monoamine oxidase
It interferes with the action of carbonic anhydrase
Interferes with the action of Acetyl chlolinesterase
Autonomic nervous system