Which of the following antiepileptic is not associated with congenital malformation when used in pregnant woman?
Phenytoin, Valproic acid and Phenobarbitone when given during pregnancy are teratogenic. Valproate given during pregnancy causes neural tube defects. Phenytoin produces fetal hydantoin syndrome and carbamazepine is associated with the development of minor foetal malformations. Phenobarbitone is not associated with teratogenic effects. Ref: Essentials of Medical Pharmacology By K D Tripathi 5th Edition, Page 371,4.
Phenytoin
Valproic acid
Carbamazepine
Phenobarbitone