Side effects of a drug arise due to interactions of the drug to molecules other than the target.These effects of the,drug can be minimized by its high:
If a drug is more specific in action, it acts only in that paicular organ so no systemic side effects will be seen and targeted cancer therapy using nanopaicles is also bases on this approach Ref; KD Tripathi pharmacology 7 th edition (page no; 84)
Specificity
Solubility
Affinity
Hydrophobicity
General pharmacology