Aquaporin deficiency cause?
1. Nephrogenic diabetes insipidus: Aquaporin 2" gene mutation impede the normal functionality of the kidney water channel, which results in the kidney being unable to absorb water. Autosomal recessivemanner. 2. Liddle syndrome: Gain of function of epithelial Na channel (ENaC) 3. Bater syndrome:- Defect in "Na-K-2Cl cotranspoer, Cl channel & ROMK" in loop of Henle. 4. Gitelman syndrome: Defect in "Na+-Cl- cotranspoer and TRPM6 transpoer" in DCT.
Nephrogenic diabetes insipidus
Liddle syndrome
Baer syndrome
Gitelman syndrome
NEET Jan 2020