Maximum collagen in wound healing is seen at-
STEPS IN WOUND HEALING Within 24 hours, neutrophils are seen at the incision margin, migrating toward the fibrin clot (neutrophilic infiltration + blood clot) Within 24 to 48 hours, epithelial cells from both edges have begun to migrate and proliferate along with the dermis and form a continuous thin epithelial layer. day 3, neutrophils have been largely replaced by macrophages, and granulation tissue progressively invades the incision space, Collagen fibres are now evident at the incision margins but do not bridge the incision day 5, neovascularization reaches its peak as granulation tissue fills the incisional space, collagen fibrils bridge the incision, full epithelial thickness with surface keratinisation second week, there is continued collagen accumulation and fibroblast proliferation end of the first month, the scar consists of a cellular connective tissue, largely devoid of inflammatory cells, replacement of collagen type 3 with collagen type 1 ref:-basic pathology, robbins 9thed, page 71
End of first week
End of second week
End of third week
End of 2 months
General pathology