Response to iron in iron deficiency anemia is denoted by?
Ans. is 'b' i.e., Reticulocytosis Response to iron therapy When specific iron therapy is given, patients often show rapid subjective improvement, with disappearance or marked diminution of fatigue, lassitude, and other non-specific symptoms. This response may occur before any improvment in anemia is observed. The earliest hematological evidence of recovery is increase reticulocytes and their hemoglobin content. The reticulocytes attain a maximal value on the 5th to 10th day after institution of therapy and thereafter gradually return to nonnal. The reticulocyte response may not be detectable in mild iron deficiency anemia. The blood hemoglobin level is the most accurate measure of the degree of anemia in iron deficiency anemia. During the response to therapy, the red cell count may increase temporarily to values above normal, but the hemoglobin value lags behind. The red cell indices may remain abnormal for some time after the normal hemoglobin level is restored. As recovery occurs, a normocytic cell population gradually replaces the microcytic population; and one of the early signs of response to therapy is an increase in RBW from pretreatment level. When treatment is fully effective, hemoglobin reaches normal levels by 2 months after therapy is initiated, regardless of staing values. Of the epithelial lesions in iron deficiency, those affecting the tongue and nails are the most responsive to treatment.
Restoration of enzymes
Reticulocytosis
Increase in iron binding capacity
Increase in hemoglobin