Which of the following if combined with Rivastigmine, decreases its efficacy
Rivastigmine is used in Alzheimer's disease. It inhibits acetylcholinesterase and increases the level of ACh.
Tricyclic antidepressants have strong anticholinergic actions. Therefore, these can reduce the efficacy of Rivastigmine.
Depression is commonly seen in patients with Alzheimer's disease. The anti-depressants that are used should have minimum anticholinergic activity, therefore SSRI or MAO-inhibitors are preferred.
Selective serotonin reuptake inhibitors
Reversible inhibitor of MAO-A
Tricyclic antidepressants
Atypical antidepressants