The most important investigation in the given case to diagnose if the condition is a neoplasm?
Ans. (a) JAK-2The figure shows increased platelets in smear and increased megakaryocytes in bone marrow. To diagnose this as essential thrombocythemia (neoplasm); JAK-2 mutation analysis should be done.
JAK-2
EPO level
PaO2
Bone marrow aspiration and biopsy
Misc. (W.B.C)