A patient of DVT was stabilized on warfarin. This person was given phenobarbitone. Which of the following is the likely interaction between the two drugs?
-- Barbiturates like phenobarbitone are powerful enzyme inducers -- These increase the metabolism of warfarin and decrease its anticoagulant effect.
Phenobarbitone increases the absorption of warfarin
Phenobarbitone increases the metabolism of warfarin
Phenobarbitone displaces warfarin from plasma protein binding sites
All of the above
Sedative-Hypnotics and Parkinsonism