False about Paget disease of the nipple:
Ans: b (It is an eczematous condition) Ref: Bailey, 24th ed, p. 837Paget's disease of nippleIs a superficial manifestation of an underlying carcinoma(DCIS or invasive ductal carcinoma)It presents as an eczema - like condition of nipple and areola, which persists despite local treatment.Nipple is eroded slowly and eventually disappears (poor prognosis)- Microscopy - Characterised by presence of large, ovoid cells with abundant clear, pale-staining cytoplasm in the Malpighian layer of epidermis.Eczema of nipplePaget disease of nipple- Often bilateral- Unilateral- Is often seen during lactation- Is seen at menopause- Itches- Does not itch- Vesicles present- No vesicles found- Nipple remain intact- Nipple may be destroyed- No lump felt deep to nipple- May feel a lump deep to the nipple
Leads to destruction of whole nipple
It is an eczematous condition
Associated with underlying carcinoma
Associated with poor prognosis
Breast Cancer - Types and Staging