Regarding the antibacterial action of gentamicin, which of the following statements is most accurate?
(Ref:Katzung 10/e p756, 757) Aminoglycosides show concentration dependenbt killing and prolonged post antibiotic effect. For details, refer to text.
Efficacy is directly propoionate to the time that the plasma level of the drug is greater than the minimal inhibitory concentration
Gentamicin continues to exe antibacterial effects even after plasma levels decrease below detectable range
Antibacterial activity is often reduced by the presence of an inhibitor of cell wall synthesis
The antibacterial action of gentamicin is time dependent
Other topics and Adverse effects