A 31-year-old woman has had a persistent fever for the past 2 months. Her temperature has ranged from 38.3degC to 38.6degC on multiple occasions. On physical examination, she has diffuse abdominal pain and mild splenomegaly, but no hepatomegaly or lymphadenopathy. Laboratory studies show Hgb, 13.2 g/dL; Hct, 39.8%; MCV, 930 mm3; platelet count, 242,000/ mm3; and WBC count, 12,290/ mm3 with 71% segmented neutrophils, 19% lymphocytes, and 10% monocytes. CT imaging of her abdomen shows an ill-defined pelvic soft- tissue density mass with a mottled lucent center and a small, square, radiopaque area. Review of her medical record reveals that a salpingo-oophorectomy for ectopic pregnancy was performed on the left side 3 months ago. Which of the following is the most likely cause of her persistent fever?
She has fever of unknown origin (FUO), at least until a record review correlated with the CT imaging suggests that the mass is a residual hemostatic sponge placed at the time of surgery. Radiopaque markers or radio-frequency identification (RFID) chips can be incorporated into such objects for identification. The mild splenomegaly is consistent with intra-abdominal abscess. There is a long differential diagnosis list for FUO. A mass could represent a neoplasm, but lymphomas do not tend to have significant necrosis and a lucent center. Sarcoidosis tends to involve multiple organs, but lymph node enlargement is likely, although central caseation is not. At the prior surgery, an ovarian neoplasm should have been identified, as would pelvic inflammatory disease that may produce a tubo-ovarian abscess.
Abscess
Non-Hodgkin lymphoma
Ovarian cystadenocarcinoma
Sarcoidosis
Misc.