All are toxicities seen with amiodarone therapy except?
Ans. is 'd' i.e., Productive cough Amiodarone and cirrhosis o Abnormal liver function is frequently repoed with amiodarone use but clinically symptomatic disease is rare.o Hepatomegaly, cholestasis, acute hepatitis and rarely fulminant liver failure have been recorded, however amiodarone toxicity presenting with cirrhosis is exceedingly rare.o But there have been repoed cases of cirrhosis with amiodarone use, referred to as pseudo-alcoholic cirrhosis. Amiodarone and cough o The most impoant adverse effect of amiodarone is pulmonary toxicity.o Patient usually present with chest pain, dyspnea and dry cough (not productive cough)o Fatal pulmonatyfibrosis may occur.o Pulmonary toxicity is dose related.
Pulmonary cirrhosis
Corneal micro-deposits
Cirrhosis of liver
Productive cough