Congenital 17-hydroxylase deficiency leads to hypeension due to accumulation of?
* Two forms of adrenal hyperplasia (ie, 11-hydroxylase and 17-hydroxylase deficiency) result in hypeension due to the accumulation of supraphysiologic concentrations of deoxycoicosterone. * This weak mineralocoicoid has little consequence at physiologic concentrations but causes sodium retention and hypeension at the supraphysiologic concentrations that occur in these conditions.
Deoxycoicosterone
Coisol
17 hydroxy pregnediol
17 hydroxy progesterone
Disorders of Adrenal Gland