Which of the following statements is true regarding kappa, lambda and heavy chain immunogloblins ?
Ans. is 'c' i.e., The chains are formed by genetic rearrangement after maturation Genetic rearrangement of antibody . During B cell development, diversity of the antigen binding variable region of Ig is generated by an ordered set of Ig gene rearrangement. . An antibody is composed of two identical light and two identical heavy chains, and the genes specifying them are found in the 'V' ( variable ) region and the 'C' ( constant ) region. . As the name suggests, genetic rearrangement occurs in variable region , constant region remains constant, i.e. there is no rearrangement at constant region. In the heavy chain, 'V' region there are three segments ; 'V', 'D' and . For heavy chain, there is first a rearrangement of D segment to J segment, followed by a second rearrangement between a V gene segment and the newly formed D-J sequence; the C segment is aligned to the V-D-J complex to yield a functional Ig heavy chain gene (V-D-J-C). . Similar rearrangements occur for light chain V- region except there are only two segments involved; 'V' and %Y. . Light chain rearrangement occurs during later stages. A functional K or X chain is generated by rearrangement of 'V' segment to J segment, ultimately yielding an intact Ig molecule composed of heavy and light chain.
Coded in the same site of a chromosome
Coded in different sites of same chromosome
The chains are formed by genetic rearrangement after maturation
All