All of the following statements about unfractionated heparin are true except:-
Heparin Warfarin 1. Route of administration parenteral (IV, SC) Oral 2. Onset of action Rapid Delayed (1-3 days) 3. Activity In vitro and in vivo In vivo only 4. MOA Activates Antihrombin III | Activation of II, VII, IX, X 5 Monitoring by aPTT PT 6. Antagonist Protamine sulphate Vit. K1 (Phytonadione) 7. Placental barrier Does not cross placenta Fetal warfarin syndrome 8. Use To initiate therapy For maintenance
It is a powerful anticoagulant only in vivo
Protamine sulfate is the antidote
It should not be given by intramuscular route
It acts by inhibiting factor IIa and Xa
Hematology