Cisatracurium, pure CIS isomer of atracurium all true except:-
Atracurium molecule is mixture of 10 stereoisomers in which Cis isomer is only 15 %. A total Cis isomer was seperated and new drug was prepared which is Cisatracurium. Cisatracurium a pure CIS isomer of atracurium produces no /minimal histamine release and is more potent than atracurium. Thus it is given in less dose and causes less by product laudanosine production at equipotent dose.
Is metabolized primarily by Hoffman degradation
Is cardiovascular stable
Produces more laudanosine than an equipotent dose of atracurium
Has onset & duration similar to atracurium
Neuromuscular Blocker