True regarding clavulanic acid is -
Ans. is 'a' i.e., Deactivates Beta lactamase Clavulanic acido Clavulanic acid is a beta-lactamase inhibitor. Addition of clavulanic acid re-estabilishes the activity of amoxicillin against b-lactamase producing organisms,o Clavulanic acid has a b-lactam ring but no antibacterial activity of its own.o Clavulanic acid is a suicide inhibitor, it gets inactivated offer binding to the enzyme because of irreversible binding.o Clavulanic acid is a progressive inhibitor, binding is reversible initially, but become irreversible later due to covalent bonding, i.e. inhibition increases with time.Other beta-lactamase inhibitorso Sulbactam is combined with ampicillin.o Tazobactom is combined with piperacillin.
Deactivates beta lactamase
Decreases renal excretion of amoxycillin
Potentiates action of penicillin
Decreases the side effects of amoxicillin
Anti Microbial