True regarding multiple myeloma is all. except :
Answer is C (Increased alkaline phosphatase) Serum Alkaline phosphatase is usually normal even with extensive bone involvement because of absence of osteoblastic activity - Harrisons 16th/ 659 Bone pain is the most common symptom in myeloma Q Bone lesions are lytic in nature and are rarely associated with osteoblastic new bone formation. Therefore Radioisotope bone scanning is less useful in diagnosis than plain radiography c) No hot spot is seen on bone scan Q Alkaline phosphatase (marker of osteoblastic activity) is not raised.
Bone pain
Lytic lesion
Increased alkaline phosphatase
Taerate resistance acid phosphatase positive