A 63-year old man presented with massive splenomegaly, lymphadenopathy and a total leucocyte count of 17000 per mm3. The flow cytometery showed CD 23 negative and C 5 positive monoclonal cells with bright kappa positively comprising 80% of the peripheral blood lymphoid cells. The most likely diagnosis is -
65 years old man with splenomegaly, lymphodenopathy CD-23 negative and CD-5 positive B-cell suggest the diagnosis of mantle cell lymphoma.

Clinical features of mantle cell lymphoma 

It is usually present in fifth to sixth decade with male preponderance.
The most common presentation is painless lymphodenopathy.
Splenomegaly may occur.
Occasionally, multifocal mucosal involvement of the small bowel and colon produces lymphomatoid polyposis → of all forms of NHL, mantle cell lymphoms is most likely to spread in this fashion.
Mantle cell lymphoma
Splenic lymphoma with villous lymphocytes
Follicular lymphoma
Hairy cell leukemia