Which of the following opioids should not be used with MAO inhibitors?
pethidine Nonselective MAO inhibitors interfere with hydrolysis but not with demethylation of pethidine - norepithidine is produced in excess and excitement occurs. Excitatory effects include trmors, mydriasis, hyperreflexia, delirium, myoclonus, convulsions etc. Ref: KD Tripathi 8th ed.
Morphine
Pentazocine
Buprenorphine
Pethidine
Central Nervous system