A 20-year-old female presents for an infertility workup. She has never had a menstrual period. She is short with a broad chest, webbed neck, and low-set ears. It is demonstrated that she has an abnormal karyotype.The cause of the woman's abnormal karyotype is which one of the following?
Monosomy X (Turner syndrome) can be as a result of either maternal nondisjunction (an egg is created lacking an X chromosome, whereas another egg has two X chromosomes) or paternal nondisjunction (a sperm lacks the X chromosome, whereas another sperm contains both the X and Y chromosomes). Turner syndrome is not caused by translocation events, either reciprocal or Robertsonian (recall that Robertsonian translocations only occur among acrocentric chromosomes, and the X chromosome if not acrocentric).
Maternal nondisjunction
Paternal nondisjunction
Both maternal and paternal nondisjunction
Either maternal or paternal nondisjunction
Molecular Genetics