Extent of nicotinic receptor blockade required for neuromuscular transmission failure due to non-depolarizing neuromuscular blockers:-
Non depolarising neuromuscular blocker are competitive blockers and when more than 80 -90 % receptor is blocked then only neuromuscular transmission fails. Characteristic of NDNB 1. Decreased twitch response to a simple stimulus. 2. Fade on tetanic stimulus 3. Train of four response is seen 4. TOF ratio <1 5. Post tetanic potentiation 6. Potentiation of other nondepolarising drugs Antagonism by anticholinesterase
<5%
About 20%
About 30%
>80% - 90%
Neuromuscular Blocker