Paralysis of 3rd, 4th, 6th nerves with involvement of ophthalmic division of 5th nerve, localizes the lesion to -
Paralysis of 3rd, 4th, 6th nerve and involvement of ophthalmic division of 5th nerve → cavernous sinus thrombosis.
Paralysis of 3rd, 4'h, 6th nerve, ophthalmic division of 5th nerve plus optic nerve signs→ orbital apex syndrome.
Cavernous sinus
Apex of orbit
Brainstem
Base of skull