Which of the following statements best describes the mechanism of action of benzodiazepines?
Benzodiazepines are GABA facilitatory drugs. These activate BZD receptors that increase the binding of GABA to GABAA receptors. That result in increase in frequency of chloride channels in neurons resulting in CNS depression.
Benzodiazepines activate GABAB receptors in the spinal cord
Benzodiazepines block glutamate receptors in neuronal pathways in the brain
They increase the frequency of opening of chloride ion channels that are coupled to GABAA receptors
They are direct acting GABA receptor agonists in the CNS
Sedative-Hypnotics and Parkinsonism