All of the following statements about amlodipine are true except:
(Ref: KDT 6/e p531) Amlodipine is the longest acting DHP. It undergoes little first pass metabolism and is distributed widely. metabolites of amlodipine are inactive.
It acts by conversion to an active metabolite in the liver
It has a very large volume of distribution
It undergoes very little first pass metabolism and possesses high and consistent oral bioavailability
It has a very long elimination half life
Other topics and Adverse effects