In which of the following disorders is administration of barbiturates contraindicated in
Contraindications of barbiturates: Acute intermittent porphyria- Barbiturates exacerbate it by inducing microsomal enzymes (d aminolevulinic acid synthetase) and increasing porphyrin synthesis. Liver and kidney disease Severe pulmonary insufficiency e.g. emphysema Obstructive sleep apnoea Uses of barbiturates: Anxiety disorders Epilepsy Kernicterus / Congenital nonhemolytic jaundice : Phenobarbitone induces conjugation of bilirubin and hastens clearance of jaundice.
Anxiety disorders
Acute intermittent porphyria
Kernicterus
Refractory status epilepticus
Sedative-Hypnotics and Parkinsonism