Albright's syndrome includes all except -
cCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues. People with McCune-Albright syndrome develop areas of abnormal scar-like (fibrous) tissue in their bones, a condition called polyostotic fibrous dysplasia. Polyostotic means the abnormal areas (lesions) may occur in many bones; often they are confined to one side of the body. Replacement of bone with fibrous tissue may lead to fractures, uneven growth, and deformity. When lesions occur in the bones of the skull and jaw it can result in uneven (asymmetric) growth of the face. Asymmetry may also occur in the long bones; uneven growth of leg bones may cause limping. Abnormal curvature of the spine may also occur. In addition to bone abnormalities, affected individuals usually have light brown patches of skin called cafe-au-lait spots, which may be present from bih . Girls with McCune-Albright syndrome may reach pubey early. These girls often have menstrual bleeding by age 2. This early onset of menstruation is believed to be caused by excess estrogen, About 50 percent of affected individuals produce excessive amounts of thyroid hormone (hypehyroidism), resulting in a fast hea rate, high blood pressure, weight loss, tremors, sweating, and other symptoms. Excess growth hormone secretion may also lead to increased expansion of the fibrous dysplasia in the bones, most visibly in the skul Rarely, affected individuals develop Cushing syndrome and it causes weight gain in the face and upper body, slowed growth in children, fragile skin, fatigue, and other health problems. In people with McCune-Albright syndrome, Cushing syndrome occurs only before age 2 . Ref - <a style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 14px;" href="
Polyostotic fibrous dysplasia
Precocious pubey in girls
Patchy pigmentation
Pseudo hypoparathyroidism
Endocrinology