The drug which can be considered as an alternative for splenectomy in severe autoimmune hemolytic anemia is:
Rituximab is effective in more than 80% of patients with severe autoimmune hemolytic anemia not responding to steroids. Ref: Harrison's principles of internal medicine, 18th edition ; Page :882.
Adalimubab
Eculizumab
Rituximab
IV immunoglobulin