Which among the following factors level is not altered in vit K deficiency?
Ans b: (Factor VIII) Ref: Harrison p.367, 728-730Coagulation factors II, VII, IX, X and protein C, S and Z are dependent on Vit K for post translational modification. Vit K also for bone protein osteocalcin and vascular smooth muscle protein- matrix glaproteinFew more points:* Gamma carboxy glutamic acid residues in the Vit k dependent factors will help in their critical action including calcium and phospholipid binding* Mutations in Vit k epoxide reductase complex 1 (VKORC1) andgene encoding gamma glutamyl carboxylase(GGCX) result in defect free enzyme and there in Vit K dependent factors with decreased activity.* Causes mild to severe bleeding episodes from birth* Prolongation of PT is the most common and earliest finding in Vit K deficiency. Factor V11 has the shortest tl/2, so PT prolonged much before changes in aPTT
Prothrombin
Factor VIII
Factor VII
Factor X
Blood