Acid phosphatase is specific to which of the following cells -
Ans. is 'a' i.e. Monocytes Wintrobes Hematology llth/e "Acid phosphatase is found in all hematopoietic cells, but the highest levels are found in macrophages and osteoclasts". Acid phosphatase Acid phosphate is a hydrolytic enzyme secreted by a number of cells. There are several isoenzymes of acid phosphatase with some tissue specificity. The isoenzymes can be fractionated by electrophoresis into five bands Band 5 Found mainly in osteoclastes, is also resistant to taarate inhibition. An identical protein is found in monocytes and kupffer cells. Band 3 The major form of plasma acid phosphatase found in normal plasma, comes from platelets, erythrocytes and monocytes. Band 2 and 4 Originates from granulocytes Band 1 Major source is prostate Resistant to taarate inhibition Remember these impoant point about acid phosphatase The activity of prostatic acid phosphate in serum is negligible. Nearly all of the acid phosphatase in normal individuals comes from platelets and erythrocytes. There is little or no acid phosphatase activity in lymphocytes, lymphoblasts, myeloblasts or erythroblasts.
Monocyte
Tlymphocyte
B lymphocyte
Myelocytes