Staphylococcus aureus causes vomiting in 16-18 hours. The mechanism of action is by
It has been suggested that SEs(staph enterotoxins) stimulate the vagus nerve in the abdominal viscera, which transmits the signal to the vomiting centre in the brain. Enterotoxin is responsible for the manifestations of staph food poisoning - nausea, vomiting, and diarrhoea 2-6 hr after consuming food contaminated with enterotoxin.
The toxin directly acts on ANS to cause the illness rather than on the gastrointestinal mucosa.
Stimulation of cyclic AMP
Vagal stimulation
Stimulation of Cyclic GMP
Acts through ganglioside GM receptor