Drug used in LUMINATE programme for non infectious uveitis is -
Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various pas of the eye and is a leading cause of visual loss. Currently available therapies are burdened with toxicities and/or lack definitive evidence of efficacy. Voclosporin, a rationally designed novel calcineurin inhibitor, exhibits a orable safety profile, a strong correlation between pharmacokinetic and pharmacodynamic response, and a wide therapeutic window. The LUMINATE (Lux Uveitis Multicenter Investigation of a New Approach to TrEatment) clinical development program was initiated in 2007 to assess the safety and efficacy of voclosporin for the treatment, maintenance, and control of all forms of noninfectious uveitis. If LUMINATE is successful, voclosporin will become the first Food and Drug Administration-approved coicosteroid-sparing agent for this condition Ref khurana 6/e
Cyclosporine
Voclosporin
Methotrexate
Infliximab
Uveal tract