The primary direct stimulus for excitation of central chemoreceptors regulating ventilation is
The main chemoreceptors involved in respiratory feedback are: Central chemoreceptors: These are located on the ventrolateral surface of medulla oblongata and detect changes in the pH of spinal fluid. Ref: guyton and hall textbook of medical physiology 12 edition page number:371,372,373
Increased H+
Increased CO2
Increased O2
Decreased CO2
Respiratory system