Lovastatin acts by inhibiting
Ans. a (HMGCoA reductase). (Ref. Harrison Medicine I6th/I43I, 2168, 2296, table 335-6)HMG-CoA REDUCTASE INHIBITORS# HMG-CoA reductase is the rate-limiting step in cholesterol biosynthesis.# By inhibiting cholesterol biosynthesis, HMG-CoA reductase inhibitors (statins) lead to -- increased hepatic LDL receptor activity and accelerated clearance of circulating LDL, resulting in a dose-dependent reduction in plasma LDL-C.# HMG-CoA reductase inhibitors are the drug class of choice for LDL-C reduction.# They also reduce plasma triglycerides in a dose-dependent fashion, which is proportional to their LDL-C lowering effects .# They have a modest HDL-raising effect (5 to 10%), and this effect is not dose-dependent.# HMG-CoA reductase inhibitors are well tolerated and can be taken in tablet form once a day.# Potential Side Effects include:Dyspepsia,- Headaches,- Fatigue,- Muscle or joint pains- Severe myopathy- Rhabdomyolysis (rarely).- Hepatitis# The risk of myopathy is increased by the presence of renal insufficiency and by coadministration of drugs that interfere with the metabolism of HMG-CoA reductase inhibitors, such as erythromycin and related antibiotics, antifungal agents, immunosuppressive drugs, and fibric acid derivatives.# Serum CPK levels do not need to be monitored on a routine basis as an elevated CPK in the absence of symptoms does not predict the development of myopathy and does not necessarily suggest the need for discontinuing the drug.DRUGS USED FOR THE TREATMENT OF HYPERLIPIDEMIADrugMajor indicationsMechanismCommon side effectsHMG-CoA reductase inhibitors (statins)Elevated (LDL)|Cholesterol synthesis;|LDL receptors,| hepatic VLDLProductionMyalgias, arthralgias, DyspepsiaBile acid sequestrantsElevated triglycerides| Bile acid excretion and| LDL receptorsBloating, constipation.Nicotinic acidElevated LDL, |HDL,Elevated TG|VLDL hepatic synthesis and | HDL.Cutaneous flushing;GI upset;Elevated glucose, uric acid, levels and liver function tests.Fibric acid derivatesElevated remnants| LPL, |VLDLDyspepsia myalgia; gall stones.
HMGCoA reductase
HMGCoA synthetase
17- Hydroxyalse
Bile-acid synthetase
Hypolipidemic