Regarding opioid induced seizures:
Controlled-release oxycodone-induced seizures. ... However, opioid-related seizure in patients with epilepsy or other conditions that may decrease seizure threshold has been described in the literature; in paicular, oxycodone has been associated with seizure in a patient with acute renal failure Ref KD Tripathi 8th ed,
They usually occur at therapeutic doses
Children are more susceptible
Seizures occur only with u-opioid agonists
Diazepam is the drug of choice in treatment
Central Nervous system