Most common genetic play in Neisseria infection is -
Ans. is 'c' i.e., Complement deficiency Complement deficiency and ncisserial infectionso The complement system is an essential component of the innate immune defence against infection by Neisseria (N. Meningitidis and N. gonorrhoeae).o People who lack or have a deficiency in complement mediated bactericidal activity are most susceptible to neisserial diseases.o Terminal complement component (C5 through C9) deficiencies and deficiencies of the alternative pathway (Properdin, C3 Factor D) have a strong effect on susceptibility to, as well as severity of, neisserial infections.1) Deficiency of terminal complement (C5 - C9) component:- Deficiency of one of the terminal components that compose membrane attack complex (MAC) predisposes patients to infection with Neisseria meningitidis or Neisseriagonorrhoeae. However, N. meningitidis infection is more common.2) Deficiencies of terminal pathway Deficiencies in components of alternative pathway, namely properdin, C3 and factor D, have been associated with increased susceptibility, almost exclusively, to meningococcal infection (amongst Neisseria).
Male gender
HLA b27
Complement deficiency
IgA deficiency
Bacteria