AZT, DD1, HAART are combination of three drugs are used in AIDS acts by
(Nucleoside reverse transcriptase inhibitors) (770-KDT 6th)* Nucleoside reverse transcriptase inhibitors (NRTIs) -Zidovudine (AZT), Didanosine (ddl) Stavudine (d4T) Lamivudine (3TC) abacavir(ABC)Single- stranded viral RNA||Virus directed reverse transcriptase(Inhibited by zidovudine triphosphate)Double - stranded viral DNA* Non nucleoside reverse transcriptase inhibitors (NNRTIs)Nevirapine (NVP) Efavirenz (EFV) Delavirdine* Protease inhibitors - Ritonavir, Indinavir, Nelfinavir, Saquinavir* Fusion inhibitor - Enfuvirtide (binding to HIV envelope glycoprotein (grp 41) and preventing fusion of viral and cellular membranes
Inhibitory effects on viral DNA
Nucleoside reverse transcriptase inhibitors
Inhibit the synthesis of group 24
P53 anti- apoptotic molecule synthesis
Anti Microbial