Maintenance of high urinary pH is impoant during methotrexate treatment because
Ref-KDT 6/e p823 Methotrexate is a weak acid and basic reabsorbed in acids urinary PH. Higher plasma concentration may result in toxicity. Therefore to decrease the reabsorptiion through renal tubes urinary pH must be maintained
Bladder irritation is reduced
It decreases renal tubular secretion of methotrexate
Leucovorin toxicity is increased in a dehydrated patient
Methotrexate is a weak acid
Other topics and Adverse effects