Which of the following statments about the biodisposition of penicillins and cephalosporins is NOT accurate?
(Ref: KDT 6/e p697) Probenecid inhibits renal tubular secretion of penicillins (not reabsorption) Beta lactams eliminated by biliary route are: - Ampicillin - Nafcillin - Ceftriaxone - Cefoperazone Penicillin G has to be given by i.m. route because it is broken down by gastric acid (decreases oral bioavailability).
Oral bioavailability is affected by lability to gastric acid
Procaine penicillin G is used intramuscular injection
Renal tubular reabsorption of beta-lactams is inhibited by probenecid
Nafcillin and ceftriaxone are eliminated minly biliary secretion
Other topics and Adverse effects