Which of the following antiarrhythmic drugs can decrease the slope of Phase 0 and prolong the action potential duration?
Na+ channel blockers reduce the slope of phase 0 whereas K+ channel blockers prolong the APD. Both of these propeies are present in class Ia antiarrhythmics like quinidine and procainamide.
Lignocaine
Propanolol
Quinidine
Adenosine
Hematology and CVS