All of the following statements regarding primary effusion lymphoma are true except -
Two variants of immunoblastic lymphoma that are seen primarily in HIV-infected patients are primary effusion lymphoma (PEL) and its solid variant, plasmacyticlymphoma of the oral cavity. PEL, also referred to as body cavity lymphoma, presents with lymphomatous pleural, pericardial, and/ or peritoneal effusions in the absence of discrete nodal or extranodal masses. The tumor cells do not express surface markers for B cells or T cells and are felt to represent a preplasmacytic stage of differentiation. While both HHV-8 and EBV DNA sequences have been found in the genomes of the malignant cells from patients with body cavity lymphoma, KSHV is felt to be the driving force behind the oncogenesis (Harrison's Principles of internal medicine, 20 th edition, page 1566)
Also referred to as body cavity lymphoma
There is often an association with HHV-8
The proliferating cells are NK cells
Patients are commonly HIV positive
Infection