Cyclo-oxygenase-1 (COX-1) isoenzyme:
Option A, C & E is incorrect as Cyclo-Oxygenase -1 (COX-1) is a constitutive Enzyme.
Option B is correct as – Indomethacin does affect it as it’s nonselective.
​Option D is incorrect as COX-1, plays a central role in protection of the gastric mucosa, by helping in the synthesis of Prostaglandins.
Is increased by inflammation
Is predominant mode of action of Indomethacin
Is increased by lipopolysaccharide ie G –ve endotoxin
Is NOT involved in gastric mucosal protection