Which one of the following drugs does not have active metabolite?
Lisinopril is a lysine derivative of enalaprilat which is an active metabolite of enalapril. It is an oral prodrug that is conveed by hydrolysis to a conveing enzyme inhibitor, enalaprilat. Enalaprilat itself is available only for intravenous use, primarily for hypeensive emergencies. All other ACE inhibitors are prodrugs and are conveed to active metabolites by hydrolysis, primarily in the liver. Lisinopril doesn't require hydrolysis to become active metabolite. Its oral absorption is low and incomplete. Its half-life is about 12 hours. the active metabolite of diazepam-oxazepam Allopurinol is conveed to oxypurinol by xanthine oxidase propranolol undergoes hydrolysis to form active metabolite Pg no- 273 Basics and clinical Pharmacology G. Katzung 13th edition
Diazepam
Propanolol
Allopurinol
Lisinopril
General pharmacology