Which of the following does not occur in lysosomal storage disorders:
Lysosomal storage disorders : Inborn diseases due to lack or inactivity of lysosomal hydrolases, transpoers or integral membrane proteins. Have severe neurological abnormalities. Large vacuoles and ubiquitinated aggregates, promoting degradation and induction of lysosome biogenesis. Defects in apoptosis. Substrate accumulation in lysosomes increase the size of lysosomes.
Increased number and size of lysosomes
Accumulation of the polyubiquinated proteins
No neurological deficit
Apoptosis defects
Miscellaneous