Folinic acid is specifically indicated for
Methotrexate toxicity:- Folinic acid (Leucovorin, citrovorum factor, 5-formyl-THFA) is an active coenzyme form which does not need to be reduced by DHFRase before it can act. Methotrexate is a DHFRase inhibitor; its toxicity is not counteracted by folic acid, but antagonized by folinic acid. Ref:- kd tripathi; pg num:-611
Anaemia associated with renal failure
Pernicious anaemia
Counteracting toxicity of high dose methotrexate
Prophylaxis of neural tube defect in the offspring of women receiving anticonvulsant medication
Hematology