In sickle cell anemia
Sickle cell anemia is caused by mutation in the beta globin chain, that changes the amino acid glutamate to valine in the 6th position of beta globin chain of HbRef: Textbook of medical physiology by N Geetha, 3rd edition, page no. 94
Glutamate replaces valine
Valine replaces glutamate
Valine replaces aspaate
Aspaate replaces valine
Cardiovascular system