The ligand-receptor complex dissociates in the endosome because
Ligand-gated channels are opened by binding of effectors. The binding of a ligand to a receptor site on the channel results in the opening (or closing) of the channel (Fig. 2.11). The ligand may be an extracellular signaling molecule or an intracellular messenger.Ref: DM Vasudevan, page no: 15
Of its large size
The vesicle looses its clathrin cost
Of the acidic pH of the vesicle
Of the basic pH of the vesicle
membrane structure and function