All are true regarding Primary CNS lymphoma except:
Ans is 'a' i.e. ie Radiotherapy and chemotherapy is of no value Primary CNS lymphomaThese are B cell malignancies that present within the neuraxis without evidence of systemic lymphoma.They occur most frequently in immunocompromised individuals, specifically organ transplant recipients or patients with AIDS.In immunocompromised patients CNS lymphomas are invariably associated with Epstein - Barr virus (EBV) infection of the tumor cells.Treatment:The prognosis of primary CNS lymphoma is poor compared to histologically similar lymphoma occurring outside the CNS.Many patients experience a dramatic and radiographic clinical response to glucocorticoids however it inevitably relapses within weeks.The mainstay of definitive therapy is chemotherapy including high-dose methotrexate. This is followed in patients < 60 years with radiotherapy.The mainstay of definitive therapy is chemotherapy.A single dose of rituximab is generally administered prior to cytotoxic chemotherapyChemotherapy includes high-dose methotrexate, but multi agent chemotherapy, usually adding vincristine and procarbazine, appears to be more effective than methotrexate alone.Chemotherapy is followed in patients <60 years with whole-brain radiation therapy (WBRT).Despite aggressive therapy >90% of patients develop recurrent CNS disease.
Radiotherapy and chemotherapy is of no value
Occurs in AIDS pt.
Commonly occurs in immuno-compromised persons
EBV may be a cause /
Central Nervous System Tumors