Within the RCBC, hypoxia stimulates glycolysis by which of the following regulating pathways?
Rapapo Leubering Cycle (BPG Shunt) In the erythrocytes, step 6 of glycolysis is bypassed. Bis phosphoglycerate mutase conves 1,3- bisphosphoglycerate (BPG) to 2,3-BPG. Then BPG phosphatase removes the phosphate group to form 3-phosphoglycerate Significance of BPGThe 2,3-BPG combines with hemoglobin and reduces the affinity towards oxygen. So, in presence of 2,3-BPG, oxyhemoglobin will unload oxygen more easily in tissues.Under hypoxic conditions, the 2,3-BPG concentration in the RBC increases, thus oring the release of oxygen to the tissues even when PO2 is lowThe compensatory increase in 2,3-BPG in high altitudes ors oxygen dissociation. BPG is increased in fetal circulation.In this shunt pathway, no ATP is generatedRef: DM Vasudevan, 7th edition, page no: 100
Hypoxia Stimulates pyruvate dehydrogenase by increased 2, 3 BPG
Hypoxia inhibits hexokinase
Hypoxia stimulates release of all Glycolytic enzymes from Band 3 on RBC membrane
Activation of the regulatory enzymes by high PH
Metabolism of carbohydrate