During a clinic office visit, a 35-year-old male stockbroker shows signs of excessive nervousness and irritability and complains that the office is too hot. History and physical examination reveals the presence of a goiter and exophthalmia. Laboratory analysis of his blood reveals high antibody titers against the thyroid-stimulating hormone (TSH) receptor. Which of the following is the most likely diagnosis?
Loss of tolerance by the immune system to certain self-components can lead to the formation of antibodies, causing tissue and organ damage. Such diseases are referred to as autoimmune diseases. There are a host of autoimmune diseases characterized by the auto anti-bodies. The presence of a "butterfly" rash is a classic cutaneous sign of SLE and is characterized by a rash over the bridge of the nose and on the cheeks.ABO BLOOD GROUPSGroupAntigen on Red CellAntibody in PlasmaAAAnti-BBBAnti-AABA and BNo anti-A or anti-BONo A or BAnti-A and anti-B COMPATIBILITY OF BLOOD TRANSFUSIONS BETWEEN ABO BLOOD GROUPSa RecipientDonorOABABOYesYesYesYesA (AA or AO)NoYesNoYesB (BB or BO)NoNoYesYesABNoNoNoYes a"Yes" indicates that a blood transfusion from a donor with that the blood group to a recipient with that blood group is compatible, that is, no hemolysis will occur. "No" indicates that the transfusion is incompatible and that hemolysis of the donor's cells will occur.
Goodpasture syndrome
Graves' disease
Hashimoto disease
Juvenile-onset diabetes mellitus
Immunology