Which of the following conditions is associated with microcytic hypochromic anemia
Ref Harrison 19 th ed pg 637 Hypochromia and microcytosis characterize all forms of b thal- assemia because of the reduced amounts of hemoglobin tetramers . In heterozygotes (b thalassemia trait), this is the only abnormality seen. Anemia is minimal. In more severe homozygous states, unbalanced a- and b-globin accumulation causes accumulation of highly insoluble unpaired a chains. They form toxic inclusion bod- ies that kill developing erythroblasts in the marrow. Few of the pro- erythroblasts beginning erythroid maturation survive. The surviving RBCs bear a burden of inclusion bodies that are detected in the spleen, shoening the RBC life span and producing severe hemolytic anemia
Sickle cell anemia
Thalassemia
Fanconi's anemia
Hereditary spherocytosis
Haematology