True about senile systemic amyloidosis ?
Ans. is `d' i.e., TransthyretinSenile systemic amyloidosis (SSA) SSA is characterized by deposition of wild - type transthyretin (TTR) - based amyloid in parenchymal organs in elderly individuals.SSA is common disease, affecting approximately 25% of the population greater than 80 years old.SSA is characterized by amyloidosis clinically limited to hea; therefore, initially it was referred to as senile cardiac amyloidosis.o This form of cardiac amyloidosis tends to run a benign clinical course and is not associated with extracardiac manifestations. However, some elderly male patients may have extensive amyloid deposits in the atria, ventricles or hea valves, producing CHF and death.
Systemic involvement present
AA amyloid
Hea failure is predominant presentation
Transthyretin