Histology of acute rejection of renal transplant are?
Ans. is 'd' i.e., Neutrophilic infiltration MORPHOLOGICAL CHANGES OF RENAL TRANSPLANT REJECTION - 1.In Hvperacute rejection o The primary target is small blood vessels. There is Fibrinoid necrosis of vessels Thrombosis Ischemic necrosis of renal coical parenchymal cells (Renal coical necrosis). Immunoglobul in and complement deposition in the vessel wall. 2.In acute rejection Acute cellular rejection o Characterized by interstitial infiltrate of mononuclear cells mainly CD4 T cells and CD8 T cells. o Mild interstitial hemorrhage. o Injury to vascular endothelial cells - Endothelitis. o Focal tubular necrosis. Acute humoral rejection o Characterized by nectrotizing vasculitis that involves Significant endothelial damage Neutrophilic infiltration Deposition of immunoglobulins, fibrin and complement Thrombosis o Intimal thickning due to proliferation of fibroblasts myocytes and foam cells. o Necrosis of renal paranchyma. o Presence of C4b in peritubular capillaries is the defenitive indication of humoral rejection. 3)Chronic rejection o It results from prolong slow damage to endothelial cells of the vessels, resulting in progressive obliteration of lumen. o It is characterized - Interstitial infiltrate of mononuclear cells containing large number of plasma cells and eosinophils that cause interstitital fibrosis. Vascular intimal fibrosis, principally in coical aeries. Tubular atrophy (contrast with acute humoral and cellular rejection, where coical necrosis predominate). Duplication of basement membranes of glomeruli --> chronic transplant glomerulopathy.
Aeriolar hyalinosis
Eosinophilic infiltration
Glomerular vasodilation
Neutrophilic infiltration