A 45-year-old female underwent hysterectomy for dysfunctional uterine bleeding. Following are the gross and histological findings. Which of the following is the most likely diagnosis?
Diagnosis- Leiomyoma of uterus Well circumscribed growth arising in uterine wall from myometrium Can be Multiple in number hanges which can be seen- hyaline degeneration, calcification. Common signs and symptoms include abnormal bleeding, urinary frequency due to compression of the bladder, sudden pain from infarction of a large or pedunculated tumor, and impaired feility. Mutations in the gene MED12 occur in roughly 70% of uterine leiomyomas. Microscopic Examination: Well differentiated spindle shaped smooth muscle cells in a whorl pattern. Individual muscle cells are uniform in size and shape and have a characteristic oval nucleus and long, slender bipolar cytoplasmic processes. Mitotic figures are scarce.
Leiomyosarcoma
Leiomyoma
Mixed Mullerian tumor
Vaginal carcinoma
Systemic Pathology