Mechanism of action of theophylline in bronchial asthma is:
Ans. (A) Phosphodiesterase 4 inhibition(Ref: Katzung 11th/e p345; KDT 8th/e p245)Theophylline is used in bronchial asthma. Its mechanism of action is:Inhibition of phosphodiesterases particularly PDE-4.Antagonism of adenosine receptors.Enhancement of histone deacetylation. Acetylation of histone is required for activation of inflammatory gene transcription. By inhibiting this process, low-dose theophylline may restore responsiveness to corticosteroids.
Phosphodiesterase 4 inhibition
Beta2 agonism
Anticholinergic action
Inhibition of mucociliary clearance
Asthma