Prophylactic antibiotics are most effective during
In the first 4 hours, after a breach in an epithelial surface and underlying connective tissues, there is delay in the mobilisation of host defences. This period is called 'decisive period' and during this period, bacterial colonisation and established infection can begin. It is logical that prophylactic antibiotics will be most effective during this time.
Decisive period
Infection period
Latent period
Golden period