All of the following are true about pyruvate dehydrogenase deficiency, EXCEPT
PDH complex deficiency results in : Rise in pyruvate Upregulating other reactions of pyruvate metabolism (reduction to lactate by NADH-requiring LDH leading to lactic acidosis.) The most common form of PDH complex deficiency is caused by mutations to E1.
Mutation in the E1 component of PDH is the most common
Decrease in blood lactate
Ketogenic diet rich in leucine is given as a treatment
Rise in pyruvate
Link reaction