Pegloticase used in treatment of gout acts by which of the following mechanism:
Rasburicase and Pegloticase metabolize insoluble uric acid to soluble allantoin and used in the treatment of chronic gout.
It inhibits Xanthine oxidase enzyme
It metabolizes uric acid to allantoin
It inhibits the migration of inflammatory cells
It accumulates in synovial fluid and prevent the action of cytokines