Action of which anaesthetic agent is through NMDA receptors?
Molecular modeling and electrophysiology studies suggested that Xe and isoflurane selectively inhibit the N-methyl-D-aspaate (NMDA) receptor by binding to its glycine agonist site359 through the phenylalanine 758 residue. Advantages and disadvantages of xenon (Xe) anesthesia. Advantages Ine (probably nontoxic with no metabolism) Minimal cardiovascular effects Low blood solubility Rapid induction and recovery Does not trigger malignant hypehermia Environmentally friendly Nonexplosive Disadvantages High cost Low potency (MAC = 70% Ref: Miller's anesthesia 8th edition Ref: Morgan & Mikhail's clinical anesthesiology 6e
Xenon
NO
Succinylcholine
Etomidate
General anaesthesia