Antiparkinson's drug known to cause cardiac valvular fibrosis is
Pergolide, ergot derivative, directly stimulates both D1 and D2 receptors. It has been widely used for parkinsonism but is no longer available because its use has been associated with the development of valvular hea disease.Reference: Katzung Pharmacology; 13th edition; Chapter 28; Pharmacologic Management of Parkinsonism & Other Movement Disorders
Levodopa
Ropinirole
Pramipexole
Pergolide
Central Nervous system