For therapeutic effect in manic depressive illness, steady-state serum lithium concentration should be maintained between
The margin of safety is narrow for lithium. monitoring of serum lithium concentration is essential for optimising therapy. Serum lithium level is measured 12 hours after the last dose to reflect the steady-state concentration; 0.5-0.8 mEq/L is considered optimum for main- tenance therapy in bipolar disorder, while 0.8-1.1 mEq/L is required for episodes of acute mania. Toxicity symptoms occur frequently when serum levels exceed 1.5 mEq/L. Ref:- kd tripathi;pg num:-449
0.2-0.4 mEq/L
0.5-0.8 mEq/L
1.0-1.3 mEq/L
1.5-2.5 mEq/L
Central Nervous system