True regarding endothelin-l are all except
Bronchodilatation ET, is primarily a paracrine regulator. It causes vasoconstriction, Bronchoconstriction, cardiac stimulation (ionotropic action), a release of aldosterone and ANP, and a decrease in GFR due to contraction of mesangial cells of the kidney.
Bronchodilation
Vasoconstriction
Decreased GFR
Has inotropic effect