True about Wallerian degeneration
Distal (Wallerian) degeneration: mediated by calcium influx and activation of axonal proteases 24 hours:neurofilaments break up and the axon fragments into sho lengths. Within 10 days:myelin decomposes into fat droplets (after 10 days, Schwann cells begins to fragment myelin sheath.....a change from myelinating to demyelinating) In 3 months: macrophages phagocytose the debris, leaving behind only endoneural tube/ ghost tube (filled by the rapidly multiplying Schwann cell's cytoplasm)
It is proximal degeneration
Myelin sheath degeneration is the first change to occur
It's a type of nerve regeneration
None
Nerve