All of the following are good prognostic factors for pediatric acute lymphoblastic leukemia, except:
Favorable prognostic markers include Age between 1 and 10 years, A low white cell count at diagnosis, Hyperdiploidy, Trisomy of chromosomes 4, 7, and 10, and the presence of a t(12;21). Several factors are associated with a worse prognosis: Infancy, older age at diagnosis (presentation in adolescence or adulthood) Translocations involving the MLL gene Higher WBC count at diagnosis (peripheral blood blast counts greater than 100,000/cumm) Presence of CNS disease at diagnosis Hypodiploidy
CNS disease at diagnosis
Initial WBC count of 50000/cumm
Hyperdiploidy
t(12;21)
Acute Lymphoblastic Leukemia