What is TRUE about Lovastatin
Ans. is 'b' i.e., Inhibits HMG CoA reductase 'c' i.e., Myositis results from prolonged use 'd' i.e., Decrease synthesis of cholesterol and cause lenticular opacityLovastatin:Mechanism of actionInhibition of HMGCoA reductase Mode of actionDecreased cholesterol synthesis Increased LDL receptors Lipoproteins affectedLDL- DecreasedVLDL- DecreasedTG- DecreasedHDL- IncreasedSite EffectsHepatic dysfunction Severe myositis, | CPK Lens opacities ContraindicationsImpaired renal function andIn combination with Gemfibrozil or Nicotinic acid Risk of myositis is increased in these conditions
Inhibits HMG CoA synthetase
Inhibits HMG CoA reductase
Myositis may result from its prolonged use
Decrease synthesis of cholesterol and causes lenticular opacity
Hypolipidemic