Side effects of fluoxetine are A/E
C i.e. Urinary retention SSRIs (ex. Fluoxetine) are almost devoid of sedation, hypotension, cardiac arrhythmia, seizure precipitation & anticholinergic side effectsQ, such as dry mouth, bad taste, urinary retention, constipation & epigastric distressQ when compared to tricyclic antidepressants. - Least sedative antidepressants are - Venlafaxine (atypical), Tianeptine & Citalopram (SSRI) > other SSRIs fluoxetine, fluvoxemine, paroxetine, seraline)Q. At that time (1993), Selective serotonin reuptake inhibitors fluoxetine, fluvoxamine, paroxetine, Seraline & Citolapram were the latest antidepressant. Now Venlafaxine, Nifazodone, Reboxetine, Miazapine, Tianeptine are novel antidepressants. - Fluoxetine is a longest acting SSRI (Selective serotonin reuptake inhibitor). It is devoid of anticholinergic, arrythmogenic, sedative (abuse liability) & Hypotensive side effectsQ. It has new constellation of mild S/E viz - Nervousness, Anxiety, Insomnia, Anorexia, Nausea, DiarrheaQ & Headache, Weight lossQ. Fluoxetine, by inhibiting drug metabolism can elevate drug levels of TCA & Haloperidol to dangerous level. - Gastrointestinal S/E of SSRI's are anorexia, nausea, vomiting, diarrheoa. Anorexia is most common in fluoxetine & weight loss begin as soon as drug is taken & peak at 20 weeks, after which weight often returns to baseline. Although most patient loose weight but some person gain weight while taken fluoxetine. (Kaplan & Sadock's - Synopsis of Psychiatry 9/e P. 1099) - Buprenorphine & Dextroprophoxyphene are opioids & have abuse liability. - Increased psychomotor activity like anxiety, akathesia, agitation and insomnia is seen in one quaer of persons initiating treatment with SSRIs specifically fluoxetine. Tianeptine is an antidepressant which increase rather than inhibit 5-HT (Serotonin) uptakeQ. Treatment of choice for OCD - Behaviour therapyQ. Drug of choice for OCD is fluoxetineQ > ClomipramineQ
Weight gain
Sweating
Urinary retention
Diarrhoea