The following can be used to antagonise the action of heparin in case of overdose
HEPARIN ANTAGONIST Protamine sulfate Given i.v. it neutralises heparin weight for weight, i.e. 1 mg is needed for every 100 U of heparin. For the treatment of heparin induced bleeding, due consideration must be given to the amount of heparin that may have been degraded by the patient's body in the mean time. However, it is needed infrequently because the action of heparin disappears by itself in a few hours, and whole blood transfusion is needed to replenish the loss when bleeding occurs. Protamine is more commonly used when heparin action needs to be terminated rapidly, e.g. after cardiac or vascular surgery. Ref:- kd tripathi; pg num:-620
Heparan sulfate
Dextran sulfate
Ancrod
Protamine sulfate
Hematology