Myeloma associated with good prognosis:
Multiple Myeloma:- Plasma cell tumor that manifest with multiple lytic bone lesion associated with pathologic fractures and hypercalcemia. Neoplastic plasma cell suppress normal humoral immunity and secrete paial Ig that are nephrotoxic Associated with diverse Translocation involving the Ig H locus, frequent dysregulation and overexpression of D cyclin. Translocation t (11:14 ):- Good prognosis.
t(11:14)
deletion of 13q
del 17p
t(14,16)
JIPMER 2018