A 40 years old patient with liver dysfunction is scheduled for a surgical procedure. Lorazepam can be used for pre-anaesthetic medication in this patient without concern for excessive CNS depression because the drug is:
(Ref: Katzung 6/e p450) Lorazepam and oxazepam are the benzodiazepines which are excreted from the body by glucuronide conjugation without phase 1 metabolism in the liver. So these can be used safely in hepatic dysfunction.
Selective anxiolytic like buspirone
Conjugated directly
Reversible by administration of naloxone
Forming several active metabolites
Other topics and Adverse effects