The type mutation that leads to replacement of valine for glutamate in sickle cell disease is
Sickle-cell anemia is caused by apoint mutation in the b-globin chain of hemoglobin, causing the hydrophilic amino acid glutamic acid to be replaced with the hydrophobic amino acid valine at the sixth position. The b-globin gene is found on the sho arm of chromosome 11. Ref ganong's review of medical physiology 25e
Point mutation
Silent mutation
Nonsense mutation
Any of above
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