True statements regarding vancomycin uses are all of the following except: September 2009
Ans. B: Drug of choice for pseudomembranous enterocolitis Vancomycin is used in Proven methicillin-resistant (MR) Staph. aureus (S.A.) or coagulase-negative Staphylococcal infections Serious infections where coagulase-negative Staphylococci is highly suspected (e.g., central line, prosthesis, sternotomy, etc). Endocarditis caused by methicillin-resistant Staphylococci (plus gentamicin and rifampin for prosthetic valve endocarditis caused by coagulase-negative Staphylococci). Meningitis caused by flavobacteria or Penicillin-resistant pneumococcus (plus cefotaxime) CNS shunt infection caused by methicillin resistant Staphylococci (+ rifampin) Infections caused by organisms susceptible only to vancomycin (e.g., Corynebacterium jeikium) Ampicillin-resistant enterococcal infections. Prophylaxis for major surgical procedures for implantation of prosthetic materials or devices at hospitals with a high rate of infections due to methicillin-resistant Staphylococci. A single dose administered immediately before surgery is sufficient unless the procedure lasts more than 6 hours, in which case the dose should be repeated. Prophylaxis should be discontinued after a maximum of two doses. It is second choice drug to metronidazole for antibiotic associated pseudomembranous enterocolitis caused by C.difficile.
Surgical prophylaxis in MRSA prevalent areas
Drug of choice for pseudomembranous enterocolitis
Effective in penicillin-resistant pneumococcal infection
Methicillin-resistant Staphylococcus aureus infection