Which of the following statement about Bedaquiline is TRUE:
Bedaquiline: - New antitubercular drug for MDR or XDR,- It act by inhibiting ATP synthase in mycobacteria- Food increases the bioavailability - Given along with base line antitubercular drug- Recent studies have shown cross resistance with clofazimine only. It is approved for use for 6 month. Side effect: - Derangement of LFT- Prolongs QT interval Pretomanid in combination withBedaquiline and Linezolid is approved by the FDA for the treatment of extensively drug-resistant, treatment-intolerant or nonresponsive multidrug-resistant pulmonary TB
Mycobacterial ATP synthase inhibitor
Does not prolongs QT interval
It should be given alone
It has cross-resistance with rifampicin
Antimicrobial Drugs