Valproic acid causes all EXCEPT
It causes Hirsutism REF: KDT 7th ed p. 408 Adverse effects of valproate: Anorexia, vomiting, hea burn are common Drowsiness, ataxia, tremor are dose related Alopecia, curling of hair Increased bleeding tendency, thrombocytopenia Rashes and hypersensitivity phenomenon Asymptomatic rise in serum transaminase Fulminant hepatitis in children below 3 yrs. of age Pancreatitis has been repoed Menstrual irregularities and PCOD and obesity in young girls Use in pregnancy has led to development of spina bifida and neural tube defects Interactions of valproate Valproate increases plasma levels of Phenobarbitone by inhibiting its metabolism Displaces phenytoin from its protein binding sites and decreases its metabolism causing thereby toxicity Valproate and carbamazepine induce each other's metabolism Concurrent administration of clonazepam is contra indicated because it precipitates seizures absence
It is an enzyme inducer
It causes obesity
It causes Hirsutism
It causes neural tube defects