Which of the following statements are true regarding benzodiazepines?
Benzodiazepines act on BZD receptors of GABAA-BZD receptor-chloride channel complex and increase the frequency of CI -channel opening GABA facilitatory action. Thus these are not GABA agonists. Coma, respiratory depression though rare,can occur with ultra sho acting agents like midazolam,thriazolam. Diazolam has rapid onset of action but prolonged action due to formation of active metabolized. Ref: KD Tripathi 8th ed.
It acts as GABA agonist
Diazepam is a sho acting benzodiazepines
Diazepam causes lesser respiratory depression than midazolam
Nitrazepam is metabolized in liver
Central Nervous system