All of the following factors increased acid secretion in the stomach, EXCEPT:
Factors which increase the acid secretion in stomach are vagal stimulation(acetyl choline), gastrin and histamine. Gastrin and acetylcholine promote secretion by elevating cytosolic free calcium concentrations, whereas histamine increases intracellular cAMP. Factors that inhibit HCl secretion are: Low pH in the stomach by negative feedback mechanism Intestinal influences Somatostatin Prostaglandins, epidermal growth factor transforming growth factor Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 25. Overview of Gastrointestinal Function & Regulation. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.
Histamine
Acetylcholine
Food in stomach
Gastrin