Difference between thyrotoxicosis and malignant hypehermia is -
Ans. is D ie. Elevated Serum CPK level Both thyrotoxicosis, and malignant hypehermia can cause myopathy but in hypehyrodism serum CPK level is often normal (In fact many endocrine disorders can cause myopathy but serum CPK level is normal in all of them except for hypothyroidism in which it is elevated upto 10 times) Increased CPK level is seen in malignant hypehermia*. "Malignant hypehermia is a rare complication. It is due to a genetic defect in calcium metabolism at the sarcoplasnic reticulum level of skeletal muscle. It carries a 30% moality rate and is seen after administration of some inhalational anesthetics, amides based local anesthetics, or ocassionally muscle relaxants similar to succinilcholine. Muscle biopsy is usually required to confirm the diagnosis, but the majority of pts. will have an elevated serum CPK minutes after the administration of anesthetic agents and includes high fever, tachycardia, rigidity and cyanosis. Hyperkalemia, hypercalcemia and metabolic acidosis are also associated findings." " Treatment* includes active cooling of the pt. the administration of dantrolene* to block the release of calcium from the sarcoplasmic reticulum and correction of the noted serum electrolyte and acid base abnormalities."
Hypehermia
Tachycardia
Muscle rigidity
Elevated serum CPK level