The parenteral administration of streptokinase
Streptokinase (SK) is thrombolytic (or fibrinolytic) because it activates plasminogen, resulting in the increased formation of plasmin. Its efficacy is equivalent to that of tissue plasminogen activator (t-PA), but SK is not clot-specific. All thrombolytics can cause bleeding, which may be counteracted to some extent by administration of antifibrinolysins, such as aminocaproic acid.
increases the formation of plasminogen
is less effective following a myocardial infarct than t-pA
causes a high incidence of thrombocytopenia
may cause bleeding reversible by aminocaproic acid
Anti-Cancer