Hereditary retinoblastomas develop from the following chromosomal deletion?
Retinoblastoma (RB) gene has been identified as 14 band on the long-arm of chromosome 13 (13q14) and is a 'cancer suppressor' or 'antioncogenic' gene.Deletion or inactivation of this protective gene by two mutations (Knudson's two-hit hypothesis) results in the occurrence of retinoblastoma.Ref: Khurana; Comprehensive ophthalmology; 4th edition; Page no: 280
13 q14
13 p14
14 p13
14 q13
Vitreous and retina