Most common type of carcinoma breast in males is-
Ans. is 'c' i.e., Infiltrating ductal carcinoma * Carcinoma of the male breast accounts for less than 0.5% of all cases of breast cancer. * The known predisposing causes include gynecomastia and excess endogenous or exogenous estrogen. * It tends to present as a lump and is most commonly an infiltrating ductal carcinoma. * It usually presents as a unilateral lump in the breast and is frequently not diagnosed promptly. FEMALE BREAST CARCINOMA AND RELATED ONE LINERS = Most common histological subtype- IDC, NOS Most common molecular subtype- Luminal A The histological subtype with the best prognosis- Tubular > Mucinous The molecular subtype with the best prognosis- Luminal A Most common genetic mutation- p53 Most common familial genetic mutation- BRCA1 Highest susceptibility is seen with which mutation BRCA1 Association of male breast cancer, prostate cancer, pancreatic cancer, melanoma and gastric cancer- BRCA2 Association of ovarian cancer (serous)- BRCA1> BRCA2 The most common molecular group associated with BRCA1- Basal The most common molecular group associated with BRCA2- Luminal B Most important prognostic marker- Lymph node status Most important prognostic marker for metastatic cancer- ER/PR status Anti PD1 and PDL1 antibodies are under investigation for use as immune therapy in triple negative breast cancers
Ductal carcinoma in situ
Lobular carcinoma in situ
Infiltrating ductal carcinoma
Infiltrating lobular carcinoma