The following methods can be used to detect the point mutation in the beta (β)-globin gene that causes sickle cell anemia, except -
To detect point mutation, DNA analysis is required. While northern blot is a test for study of RNA.
Polymerase chain reaction, DNA sequencing and southern blot testing are rapid methods for DNA analysis, and can all be used to detect the point mutation in the globin gene.
Polymerase chain reaction with allele-specific oligonucleotide hybridization
Southern blot analysis
DNA sequencing
Northern blot analysis