All of the following statements are true, EXCEPT:
Cycloxgenase enzyme exist in two isoforms COX 1 and COX2. Cycloxygenase 1 is not an inducible enzyme, it has physiological house keeping functions. Cycloxygenase 2 is normally present only in minute quantities. It is an inducible enzyme, it is induced by cytokines and other signal molecules at the site of inflammation leading to the generation of prostaglandins which mediate inflammatory changes. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 168.
Cycloxygenase I is an inducible enzyme
Cycloyegenase II is induced by cytokines at sites of inflammation
PG's and leukotrienes are derived from arachidonic acid
Leukotrienes cause smooth muscle constriction