The pathogenesis hypochromic anemia in lead poisoning is due to -
Ans. is 'a' i.e., Inhibiton of enzymes involved in Heme biosynthesis o Lead interferes with the syntheiss of Heme by inhibiting the enzymes d Aminolevulinic acid dehydrase and Ferrochelatase. These two enzymes are involved in the synthesis of Heme.
Inhibition of enzymes involved in heme biosynthesis
Binding of lead to transferrin, inhibiting the transpo of iron
Binding of lead to cell membrane of erythroid precursors
Binding of lead to ferritin inhibiting their breakdown into hemosiderin