Flare response in triple response occurs due to-
Ans. is 4a' i.e., Vasodilation due to release of secondary mediatorsTriple responseo When a pointed object is stroked very firmly over the skin, a characteristic 3 part response develops. Its feature are-1) Red reaction {red line) is due to transient capillary engorgement (vasodilation) caused by histamine released from damaged tissue. Histamine relaxes precapillary sphincter thus leads to capillary dilatation.2) Flush or flare is spreading of redness beyond the injury (red line). It is due to arteriolar dilation mediated by axon reflex (may be an indirect effect of histamine).3) Wheal is local edema and elevation of skin due to increased permeability of capillaries and post capillary venules with consequent extravasation of fluid. Capillary permeability' is increased due to histamine and other mediators.
Vasodilation due to release of secondary mediators
Chemotaxis, adhesion of leucocytes to vessel wall
Direct vessel injury
Increased permeability
Blood: Hemostasis and Blood Coagulation