Which one of the following laboratory tests differentiates leukemoid reaction from chronic myeloid leukemia?
<p>Leucocyte alkaline phosphate score in the cytoplasm of mature neutrophils in leukamoid reaction is characteristically high & ia very useful to distinguish it from CML. Leukaemoid reaction is defined as reactive excessive leucocytosis in response to infections,intoxication ,malignant disease ,& in severe hemmorhage & hemolysis.So mature neutrophils will be more resulting in elevated LAP.But in CML,mature neutrophils will be reduced resulting in low LAP score. </p><p>Reference :Harsh mohan textbook of pathology sixth edition pg no 353.</p>
LAP (leukocyte alkaline phosphatase)
LCA (leukocyte common antigen)
MPO (myelo-peroxidase)
TRAP (tarate resistant alkaline phosphatase)
Haematology