In carcinoma head of pancreas, nausea and vomiting is due to:
Depending upon the location of the tumor, the symptoms may vary. - Periampullary carcinoma - at the ampulla; most common symptom is Jaundice. - Carcinoma at the head of pancreas - External compression of duodenum , compression of bile duct; most common symptom is jaundice. - Carcinoma at the body or tail of pancreas - asymptomatic at early stages. Most common symptom at later stages is weight loss. Due to involvement of retroperitoneal nerve plexus, there is abdominal pain. - When malignancy advances and infiltrates the 2nd pa of duodenum, it causes nausea, vomiting or gastric outlet obstruction.
External compression of duodenum
Poal vein infiltration
Proliferation infiltration of tumor into duodenum
Chemotherapy related
Pancreas