All of the following are associated with pheochromocytoma except: March 2010
Ans. C: Hypotension Pheochromocytoma is a neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue that failed to involute after bih and secretes excessive amounts of catecholamines, usually adrenaline (epinephrine) if in the adrenal gland and not extra-adrenal, and noradrenaline (norepinephrine). Extra-adrenal paragangliomas (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the ganglia of the sympathetic nervous system. Because of excessive catecholamine secretion, pheochromocytomas may precipitate life-threatening hypeension or cardiac arrhythmias. Nonspecific myocardial changes includes focal necrosis, mononuclear infiltrates and interstitial fibrosis. In some cases pheochromocytoma secrete other hormones, such as ACTH and somatostatin.
Ventricular arrhythmias
Interstitial fibrosis
Hypotension
Ectopic ACTH production