Neostigmine antagonizes nondepolarizing blockade by all of the following mechanisms, except:
Ans. is 'c' Increasing the release of Acetylcholine at the motor end plate Non-depolarizing muscle relaxants have antagonistic action on acetylcholine They act by blocking the action of acetylcholine released at the neuromuscular junction which is then not able to combine with its receptors to generate endplate potential. The antagonistic action of non-depolarizing muscle relaxant can be overcome by increasing the concentration of acetylcholine at the neuromuscular junction. This is achieved by administering anticholinesterases to the patient Anticholinesterases act by inhibiting the action of acetylcholinesterase (an enzyme that degrades acetylcholine by causing its hydrolysis). Anticholinesterases thus increase the level of acetylcholine at the neuromuscular junction. Neostigmine also has some additional direct action on cholinergic receptors.
Decreasing the breakdown of Acetylcholine at the motor end plate.
Preventing K efflux from the cell
Increasing the release of Acetylcholine at the motor end plate
Depolarization of the motor end plate
D.O.C