In vitamin B12 deficiency, folate is trapped in the form of
Methylation of homocysteine to methionine is the only way of regeneration of active THFA from methyl THFA. Methionine synthase reaction requires methyl cobalamin. So, deficiency of methyl-B12 leads to trapping of THFA in less utilised methyl-THFA - phenomenon known as folate trap.
Formyl THFA
Methenyl THFA
Methyl-THFA
Methylene-THFA
Vitamins and Minerals