The clinical effects of the antidepressant drugs is mainly based on ?
Ans. A. Change in neurotransmitter receptor sensitivityTemporal correlation of clinical effects with changes in receptor sensitivity has given rise to hypothesis that changes in neurotransmitter receptor sensitivity may actually mediate the clinical effects of antidepressant drugs.These clinical effects include not only antidepressant and anxiolytic actions but also the development of tolerance to the acute side effects of antidepressant drugs.
Change in neurotransmitter receptor sensitivity
Decreased level of neurotransmitters
Change in efficacy of neurotransmitters
None of the above