Impaired function of Aquaporin results in
ADH acts V2 receptors on DCT casuing facultative reabsorption of water by inseing Aquaporin -2 channels into apical (luminal side ). Nephrogenic DI-defect in aquaporins BATER SYNDROME - Autosomal recessive Defect in"Na-K-2Cl cotranspoer, Cl channel & ROMK"in loop of Henle LIDDLE SYNDROME - Gain of function of epithelial Na channel (ENaC) Cystic fibrosis - CH-7 defect in CFTR gene - causing defect in transmembrane chloride ion regulation.
Nephrogenic DI
Liddle syndrome
Cystic fibrosis
Baer syndrome
NEET Jan 2020