Atorvastatin is used as an anti-dyslipidemic drug. These drugs inhibit their target enzyme by:-
Atorvastatin - anti dyslipidemic drug Inhibits HMG COA reductase Competitive Inhibition Atorvastatin Antioxidant properly High efficacy, most commonly used statin capable lowering LDH by 55-60 % Longer plasma t 1/2 14 - 18 hrs Competitive Non competitive Antagonist bind with the Same receptor as the agonist Antagonist resembles chemically with the agonist Km increase Binds to another site of receptor Does not resemble Vm decrease
Competitive inhibition
Noncompetitive inhibition
Uncompetitive
Irreversible inhibition
FMGE 2017