Syndrome associated with increased risk of leukemia is:
Genetic disease association of Lympho-haematopoietic malignancies:
Acute leukaemia occurs with increased frequency with a variety of congenital disorders such as:

Down’s syndrome
Bloom’s syndrome
Klinefelter’s syndrome
Wiskott-Aldrich’s syndrome

Mohan H. Textbook of pathology. Jaypee Brothers Medical Publishers; 2015. Edition 7. Page 334
Plummer Vinson syndrome
Klinefelter syndrome
Sturge Weber syndrome
Multiple hamartoma sydrome