Which of the following anticancer drugs can cause hypercoagulable state?
Ref: Katzung 11/e p955 L-asparaginase cause the breakdown of asparagine and thus interference with protein synthesis. It can inhibit the production of clotting factors (responsible for cerebal hemorrhage) as well as anti-clotting protiens(can lead to coical viens thrombosis and other hypercoagulable state).
5-FU
L-asparaginase
Melphalan
Carmustine
Chemotherapy