b-hydroxybutyric aciduria is associated with deficiency of
b-hydroxybutyric aciduria, a pyrimidine catabolism disorder due to total or paial deficiency of the enzyme dihydropyrimidine dehydrogenase. This disorder can develop toxicity to 5-fluorouracil, also a substrate for this dehydrogenase enzyme. Reference: Harpers illustrated biochemistry 30th edition
Orotidylic acid decarboxylase
Orotate phosphoribosyl transferase
PRPP Synthase
Dihydropyrimidine dehydrogenase
Metabolism of nucleic acids