Brown atrophy occurs due to:
Lipofuscin is an insoluble pigment,also known as Lipochrome or wear and tear pigment. -Its a sign of free radical injury and lipid peroxidation. -In sectioned tissue it appears as yellow-brown,finley granular cytoplasmic,often perinuclear pigment. -It is seen in the aging cells and is paicularly prominent in the liver and hea of aging patients. -Also seen in patients with severe malnutrition and cancer cachexia. Brown atrophy of the hea
Melanin
Hemosiderin
Bilirubin
Lipofuscin
Pigmentation