Mutation not seen in diffuse type of gastric cancer?
Hereditary diffuse gastric cancer is an inherited form of gastric cancer. Patients with this disorder, resulting from a gene mutation for the cell adhesion molecule E-cadherin, have an 80% lifetime incidence of developing gastric cancer. Inactivation of the tumor suppressor genes p53 and p16 has been repoed in diffuse and intestinal-type cancers. Adenomatous polyposis coli gene mutations tend to be more frequent in intestinal-type gastric cancers. Sabiston 20e pg: 1240.
E-cadherin
APC
p16
p53
G.I.T