Tolvaptan is used for:
Ans. (A) SIADH(Ref: Harrison 20th/302)Vaptans like tolvaptan are vasopressin receptor antagonists.V1 receptor antagonists may be useful when total peripheral resistance is increased (e.g. CHF and hypertension) whereas V2 antagonists may be useful for the treatment of SIADH.Relcovaptan is selective V1 antagonist whereas lixivaptan, mozavaptan and tolvaptan are V2 selective antagonists.Conivaptan is V1a/V2 receptor antagonist used as an aquaretic (increase water excretion without affecting electrolytes like sodium) in CHF.Conivaptan is administered by i.v. injection whereas lixivaptan and tolvaptan can be given orally.
SIADH
Central DI
Von Willebrand disease
Catecholamine resistant shock
C.V.S