In Alzheimer disease, seen are:
Microscopically, the main features are as under: i) Senile neuritic plaque is the most conspicuous lesion and consists of focal area which has a central core containing Ab amyloid. ii) Neurofibrillary tangle is a filamentous collection of neurofilaments and neurotubules within the cytoplasm of neurons. iii) Amyloid angiopathy is deposition of the same amyloid in the vessel wall which is deposited in the amyloid core of the plaque. iv) Granulovacuolar degeneration is presence of multiple, small intraneuronal cytoplasmic vacuoles, some of which contain one or more dark granules called Hirano bodies. Ref: TEXTBOOK OF PATHOLOGY 6th EDITION -HARSH MOHAN PAGE NO:884
Neurofibrillary tangles
Neuritic plaques
Pick's protein
Amyloid angiopathy
Nervous system