Most sensitive antibody for SLE:
Autoantibodies in Systemic Lupus Erythematosus (SLE) Antibody Clinical Utility Antinuclear antibodies Best screening test/Most sensitive Anti-ds DNA Specific, correlate with disease activity, nephritis, vasculitis Anti-Sm Most Specific for SLE, marker for CNS lupus Anti-RNP Not specific for SLE Anti-Ro/La (SS-A) Sicca syndrome, neonatal lupus with congenital hea block Anti-histone Drug-induced lupus
Anti-nuclear
Anti-ds DNA
Anti-Smith
Anti-histone
Primary Immunodeficiency