True statement regarding mechanism of action of sulfonylureas is:-
SULFONYLUREAS These bind to sulfonuyl urea receptors 1 (SUR1) on b cells of pancreas and inhibit ATP sensitive K+ channels. This cause depolarization of b cells resulting in release of insulin. These drugs are effective only if 30 % or more of the b cells in the pancreas are available. Major limitation of these drugs is like insulin, can also cause hypoglycemia.
Increase peripheral utilization of glucose
Reduce hepatic glucose output
Act on SUR1 receptors on pancreatic beta cell membrane
Increase transcription of genes regulating glucose metabolism
Pancreas