The mechanism of the development of Acute Rheumatic Fever is which of the following?
Acute rheumatic fever results from immune response to group A streptococci (Strep. pyogenes) which cross-reacts with host tissues. The antibodies directed against the M proteins of streptococci cross react with the self antigens in the hea. In addition, CD4+ T cells specific for streptococcal peptides also react with self proteins in the hea and produce macrophage activating cytokines. So, the damage to the hea tissue is a combination of antibody and T-cell mediated reactions
Cross reactivity with exogenous antigen
Innocent bystander effect
Due to toxin secretion by streptococci
Release of pyrogenic cytokines
Rheumatic Fever