All of following are histomorphological features of Graves disease, except:
- Papillary formation which lack fibrovascular core is seen in Graves disease - Papillary formation with fibrovascular core is feature of papillary carcinoma of thyroid Graves disease: Most common cause of endogenous hypehyroidism. Caused by autoantibodies against TSH receptor that bind & stimulate thyroid follicular cells independent of endogenous trophic hormones. Thyroid gland is usually symmetrically enlarged d/t diffuse hyperophy & hyperplasia of follicular epithelial cells. Histologically, follicular epithelial cells in untreated cases are tall & more crowded than usual. This crowding often results in formation of small papillae, which project into follicular lumen & encroach on colloid, sometimes filling the follicles. Colloid within follicular lumen is pale, with scalloped margins.
Symmetrical enlargement of thyroid gland
Tall and crowded follicular epithelial cells
Small papillae having fibrovascular core projecting into the follicular lumen
Pale colloid in the follicular lumen with scalloped margins
Hypehyroidism and Goitre