A 20 years old male presents with chronic constipation, headache and Marfanoid habitus, neuromas of tongue, medullated corneal nerve fibers and nodule of 2x2 cm size in the left lobe of thyroid. The most probable diagnosis is:
- 2x2cm size of nodule most commonly medullary thyroid carcinoma - Headache because of pheochromocytoma - Therefore, diagnosis is MEN-2B MEN-2B Also known as MEN-3 Gene mutated is tyrosine kinase codon of RET oncogene. Pheochromocytoma M - MTC (most aggressive) M - marfanoid features M - mucosal neuromas. RET oncogene (tyrosine kinase domain) Autosomal dominant
Sporadic medullary carcinoma of thyroid
Familial medullary carcinoma of thyroid
MEN 2A
MEN 2B
Parathyroid and adrenal glands