In comparing the de novo synthesis of IMP and UMP, which one of the following best represents commonalities in the pathways?
De novo purine and pyrimidine biosynthesis occurs in the liver and, to a limited extent, in the brain.In pyrimidine biosynthesis, carbamoyl phosphate, produced from glutamine, CO2 , and ATP, reacts with aspartate to form a base that, after oxidation, reacts with phosphoribosyl pyrophosphate (PRPP) to form a nucleotide. This nucleotide is decarboxylated to form UMP. In purine biosynthesis, the base is produced on ribose-5-phosphate, which is generated from PRPP. Glycine is incorporated into the precursor, and tetrahydrofolate derivatives donate carbons 2 and 8 as IMP is formed. Glutamine is a nitrogen donor for both purine and pyrimidine biosynthesis. Aspartate is required for both UMP and IMP synthesis. Aspartate is also required in the conversion of IMP to AMP.
Both Require PRPP - yes; Both Require Folate Derivatives - no; Both Require Glutamine - yes; Both Require Glycine - no; Both Require Aspartic Acid - yes
Both Require PRPP - yes; Both Require Folate Derivatives - no; Both Require Glutamine - no; Both Require Glycine - no; Both Require Aspartic Acid - yes
Both Require PRPP - yes; Both Require Folate Derivatives - yes; Both Require Glutamine - yes; Both Require Glycine - no; Both Require Aspartic Acid - no
Both Require PRPP - no; Both Require Folate Derivatives - yes; Both Require Glutamine - no; Both Require Glycine - yes; Both Require Aspartic Acid - yes
Proteins and Amino Acids