Bacterial drug resistance genome occur due to
B. i.e. (Genetic mechanism) (53-60 - Ananthanarayan 7th)* Bacteria may acquire drug resistance by mutation or by one of the methods of genetic transfer. The biochemical mechanisms of resistance may be several, including decreased permeability to the drug, development of alternative pathways and production of enzymes inactivating the drugs* Plasmid** is of great medical importance as it leads to the spread of multiple drug resistance among bacteria* Genotypic variations are stable, heritable* and not influenced by environment* The discovery of gene transformation" came from the study of streptococcus pneumoniae*.* Multiple drug resistance is spread by conjugation*** F cells are able to transfer chromosomal genes to recipient cells are able to transfer chromosomal gene to recipient cells with high frequency and are known as HFr cells (does not transfer drug resistance)
After experimental of drug
Genetic mechanism
Man made
Environmental factor
General