True about Sickle cell disease are all, Except:
Sticky patch is generated as a result of replacement of a non polar residue with a polar residue Repeat from May 11 Sticky patch in sickle cell disease results from replacement of a polar residue (Glutamate) with a non polar residue Glutamate is ----Polar (Mnemonic: GP i.e. General Practioner) Valine is Non Polar (Valine) at the 6th position of the beta chain.
Single nucleotide change results in change of Glutamine to Valine
Sticky patch is generated as a result of replacement of a non polar residue with a polar residue
HbS confers resistance against malaria in heterozygotes
RFLP results from a single base change