Amoxicillin+clavulanic acid is active against the following organisms EXCEPT:
(Ref: KDT 6/e p702, 703) Staphylococcus aureus develops resistance to methicillin by acquiring altered penicillin binding proteins that have low affinity. No b-lactam antibiotic is effective against MRSA. Clavulanic acid is n inhibitor of b-lactamase. It can restore the sensitivity of penicillins against the organisms who have developed penicillinases.
Methicillin resistant Staph. aureus
Penicillinase producing Staph. aureus
Penicillinase producingN. gonorrhoea
b-lactamase producing E.coli
Other topics and Adverse effects