Hepatitis B infection persists in 3% asymptomatic individuals. Why is there an increased risk of developing liver cancer in these patients?
Hepatocellular carcinoma and HBV Hepatis B is am impoant risk factor for HCC HBV persists in 3% of asymptomatic patients. But at increased risk of developing Liver cancer because of Integration of viral DNA to host DNA- Inhibition of apoptosis -Hepato-cellular carcinoma =High rate of hepatocyte proliferation- Refers to high infectivity of the virus so basically higher chances of infection but not cancer. =Inability to induce inflammation to remove organism -Explains for carrier stage
Inability to induce inflammation to remove organism
Increased liver transaminases
Recurrent episodes of inflammation
Integration of viral DNA to host DNA
Hepatitis