Drug of choice for schizophrenic patient with poor oral absorption is?
Clozapine REF: Kaplan and sadock's synopsis in psychiatry 10th ed p. 489-490 Antipsychotics can be categorized into two main groups: the older conventional antipsychotics, which have also been called first-generation antipsychotics or dopamine receptor antagonists (DRA), and the newer drugs, which have been called second-generation antipsychotics or serotonin dopamine antagonists (SDAs) Strategies for Poor Responders of Antipsychotic: It may suggest that the patient is a rapid metabolizer of the antipsychotic or that the drug is not being adequately absorbed. Changing to another drug is preferable to changing to a high dose. If a patient has responded poorly to a conventional DRA, it is unlikely that this individual will do well on another DRA. Changing to an SDA is more likely to be helpful. Clozapine is effective for patients who respond poorly to DRAs. Double-blind studies comparing clozapine to other antipsychotics indicated that clozapine had the clearest advantage over conventional drugs in patients with the most severe psychotic symptoms, as well as in those who had previously responded poorly to other antipsychotics.
Haloperidol
Fluphenazine
Clozapine
Olanzapine