Slow acetylators of Isoniazid are more prone to develop
acetylator status of a person determines the response of drugs metabolised by acetylation Isoniazid is metabolised to acetyl-isoniazid and then to acetyl hydrazine. Accumulation of Isoniazid is responsible for peripheral neuropathy whereas acetyl hydrazine accumulation may cause hepatotoxicity. Thus slow acetylators will not be able to maetobolize the drug quickly. Refer Sharma 2/e p754
Failure of therapy
Peripheral neuropathy
Hepatotoxicity
Allergic reactions
Chemotherapy