A syndrome of multiple congenital anomalies including microcephaly, cardiac anomalies and growth retardation has been described in children of women who are heavy users of:
Teratogenecity of alcohol is the Fetal alcohol syndrome(dose related) which includes pre and post natal growth restriction,facial abnormalities like shoened palpebral fissure,low set ears,smooth philtrum,thinned upper lip, and mid facial hypoplasia CNS defects like microcephaly,mental retardation and behavioral disorders. TEXT BOOK OF OBSTETRICS,Sheila Balakrishnan,2nd edition,page no.565
Amphetamines
Barbiturates
Heroin
Ethyl alcohol
Medical, surgical and gynaecological illness complicating pregnancy