5' to 3' exonuclease activity is seen in:
Ans. (b) Repair of damaged DNARef: Harpers Biochemistry, 30th ed. pg. 389-90Two types of exonuclease activity has been described:* 5' to 3' exonuclease activity: responsible for cleavage of phosphodiester bond starting from 5' end of the strand. It is considered as the error correcting activity in damaged DNA.* 3' to 5' exonuclease activity: responsible for cleavage of phosphodiester bond starting from 3' end of the strand. This activity provides a means for proofreading if in case any wrong base is mistakenly incorporated by DNA polymerase III during DNA synthesis.
Proof reading
Repair of damaged DNA
DNA synthesis
DNA polymerase
Proteins and Amino Acids