A 32-year-old woman is confirmed as being 6 weeks pregnant. She feels well, and has no past medical history. This is her second pregnancy; the first pregnancy was uncomplicated and she delivered at term, but the baby was anemic due to beta-thalassemia. She is now worried that the current pregnancy may also be affected. Which of the following methods is most likely to establish an accurate prenatal diagnosis?
Chorionic villus sampling in the first trimester with deoxyribonucleic acid (DNA)-based diagnosis has a high degree of accuracy. Cord blood electrophoresis is suitable for screening high-risk infants at birth.
fetal ultrasound at 12 weeks
cord blood electrophoresis
chorionic villus sampling
buccal mucosal cytology of both parents
Blood