Sildenafil, a gra like medicine, can be used for which of the following conditions?
Phosphodiesterase inhibitors like sildenafil are indicated in Erectile dysfunction (Drug of choice) and Pulmonary hypeension Sildenafil selectively inhibits Phosphodiesterase (PDE)-V leading to increased cGMP levels and so is useful in erectile dysfunction. It can be administered orally. Adverse effects include headache, nasal congestion, flushing, visual disturbances (blue vision) etc. Colour vision defect is due to inhibition of PDE-VI present in the retina. Apa from their use in ED, sildenafil can also be used in the management of pulmonary hypeension. Other drugs of this group are vardenafil, udenafil, avanafil and tadalafil. Tadalafil- PDE-6 inhibition is not present
Pulmonary hypeension
Essential hypeension
Malignant hypeension
Hypeension in pregnancy
Respiratory System