Why is Glucose-6-phosphate is not acted upon by Glucose-6-phosphatase enzyme in cytoplasm, even if glycogen synthesis and breakdown takes place in the same cell, having an enzymes present in cytoplasm.
Glycogen synthesis as well as breakdown both occurs in cytoplasm But the last step of breakdown of glycogen in liver i.e. glucose -6-phosphate to glucose formation occurs in endoplasmic reticulum and not in cytoplasm, as glucose-6-phosphatase is present in the membrane of endoplasmic reticulum.
Stearic inhibition of phosphatase by albumin
Glucose-6-phosphatase is present in endoplasmic reticulum while glycogen metabolism occurs in the cytoplasm
It is thermodynamically ble only when gluconeogenesis is occurring
Require protein kinase for its activation
Glycogen