All of the following effects are produced by inhibitors of prostaglandin synthesis EXCEPT:
Prothrombin time is increased by the drugs interfering with the coagulation pathway (e.g. warfarin). As COX has no role in coagulation, inhibitors of PG synthesis do not prolong PT. However, bleeding time (BT) is prolonged by the drugs interfering with platelet function. Aspirin increases BT by acting as an antiplatelet agent.
Prolongation of bleeding time
Prolongation of prothrombin time
Prolongation of labour
Gastric mucosal damage
Histamine, 5-HT and PGs