Prolonged intake of PPI does not cause
Long-term acid suppression, especially with PPIs, has been associated with A higher incidence of community-acquired pneumonia Community and hospital acquired Clostridium difficile associated disease. Long-term use of PPIs was associated with the development of hip fractures in older women. PPIs may exe a negative effect on the anti-platelet effect of clopidogrel. The mechanism involves the competition of the PPI and clopidogrel with the same cytochrome p450 (CYP2C19).
Hypothyroidism
Pelvic fracture
Clostridium difficile infection
Increased community acquired pneumonia
Peptic Ulcer Disease