Which of the following virus produces punched out ulcer in the esophagus and biopsy demonstrate multinucleated epithelial cells with intranuclear inclusions at the margin of ulcer?
Various ulcers: Virus Herpes simplex virus Cytomegalovirus (CMV) Endoscopy Punched-out ulcers Shallow ulcerations Biopsy Diagnostic Cowdry A inclusions and multinucleated cells with nuclear molding and ground glass nuclei within a rim of degenerating epithelial cells at the margin of the ulcer. Cytomegalic cells, typically 2-4 fold larger than normal, containing basophilic cytoplasmic & intranuclear inclusion bodies surrounded by a clear halo, giving the appearance of an owl's eye within capillary endothelium & stromal cells Microscopic
Cytomegalovirus (CMV)
Herpes simplex virus (HSV)
Adenovirus
Coxasackie virus
Esophageal disorders