Regarding PCOS and hyperinsulinaemia true statement is :
In PCOS Hyperinsulinemia is seen in 50-70% cases of PCOS Insulin induces LH to cause thecal hyperplasia and secrete androgens Hyperandrogenism lowers the level of hepatic sex hormone binding globulin Metformin treats the root causes, rectifies endocrine and metabolic function, improves feility rate, used as insulin sensitiser It reduces insulin level, delays glucose absorption, liver production of glucose and improves peripheral resistance Metformin do not cause hypoglycemia in a normoglycemic women Ref: SHAW'S TEXTBOOK OFGYNECOLOGY;15 TH EDITION; PG NO: 370
Hyperinsulinaemia is observed in about 40% to 80% of women with PCOS
Hyperinsulinaemia stimulates hepatic synthesis of SHBG
Metformin causes hypoglycaemia in normoglycaemic women
Metformin has many other health benefits
PCOD, hirsutism and galactorrhea