Person had severe pruritis while taking hot shower and presents with deep vein thrombosis. He also had JAK 2 mutation and hypeension. Which of the following is the most likely diagnosis of this patient?
The presence of JAK2 mutation indicates that it is an example of Myeloproliferative disorder. Polycythemia vera is strongly associated with activating point mutations in the tyrosine kinase JAK2. Clinical features: Headache, dizziness, hypeension,Intense pruritus and peptic ulceration possibly resulting from the release of histamine from basophils. Hot showers ( AQUAGENIC PRURITUS ) will result in degranulation of the basophils thus releasing histamines.
Myelofibrosis
Polycythemia Vera
CML
AML
Myeloproliferative Disorders