Which of the following is the chromosomal composition of the complete mole?
The chromosomal composition of complete moles is usually diploid and of paternal origin. About 85 percent are 46,XX with both sets of chromosomes paternal in origin. Termed androgenesis, the ovum is feilized by a haploid sperm, which duplicates its own chromosomes after meiosis. The chromosomes of the ovum are either absent or inactivated. In other complete moles, the chromosomal pattern may be 46,XY due to dispermic feilization. Ref: Cunningham F.G., Leveno K.J., Bloom S.L., Hauth J.C., Rouse D.J., Spong C.Y. (2010). Chapter.11. Gestational Trophoblastic Disease. In F.G. Cunningham, K.J. Leveno, S.L. Bloom, J.C. Hauth, D.J. Rouse, C.Y. Spong (Eds), Williams Obstetrics, 23e.
46 XX
45X0
69 XXY
69 XXX