If a thiazide diuretic is administered for hypertension, the response seen within 24 hrs on excretion of different electrolytes is:
Ans. (C) |Na+|K+|Ca++(Ref: Goodman and Gilman 12/e p678)The following table taken from Goodman and Gilman clearly explains the answer:Excretory and Renal Hemodynamic Effects of Diuretics Na+K+H+Ca2+Mg2+Cl-HCO3- Carbonic anhydrase inhibitors||||NCV|||Osmotic diuretics|||||||||Loop Diuretics||||||||||||Thiazides||||||||Epithelial sodium channels blockers|||||||Aldosterone antagonists||||||||: Increase, |: Decrease, NC: No change, V: Variable change, I: Insufficient dataDo not get confused by the term 'within 24 hours' in the question. These are the acute effects of diuretics and these may be modified later on by the compensatory responses of the body.
|Na+|K+|Ca++
|Na+|K+|Ca++
|Na+|K+|Ca++
|Na+|K+|Ca++
Diuretics and Antidiuretics