Hb saturation with oxygen is mostly dependent on
Increased pH (decreased H+), decreased temperature, decreased PaCO2, and decreased 2,3-DPG will increase oxygen binding to the haemoglobin Ref: Biochemistry by U. Satyanarayana 3rd edition Pgno : 198,199
pO2
pCO2
HCO3-levels
Hb %
Metabolism of protein and amino acid