Antifungal used as cancer chemo therapeutic agent is?
ANSWER: (A) FlucytosineREF: Goodman Gillman manual of pharmacology and therapeutics 2008 edition page 800,http:// en.wikipedia.org/wiki/FlucytosineFlucytosine, or 5-fluorocytosine, a fluorinated pyrimidine analogue, is a synthetic antimycotic drug.Mechanisms of action: Two major mechanisms of action have been elucidated:1. One is that the drug is intrafungally converted into the cytostatic fluorouracil that undergoes further steps of activation and finally interacts as 5-fluorouridinetriphosphate with RNA biosynthesis and disturbs the building of certain essential proteins.2. The other mechanism is the conversion into 5- fluorodeoxyuridinemonophosphate which inhibits fungal DNA synthesis (Antimetabolite anticancer agent)
Flucytosine
Nystatin
Voriconazole
Terbinafine
Anti-Neoplastic Agents