Which of the following metabolic alterations would most likely be present in a chronic alcoholic compared to a non-drinker?
The principal route of metabolism of ethanol is alcohol dehydrogenase, which uses hydrogen from ethanol to form NADH from NAD+, markedly increasing the ratio of NADH to NAD+. The relative excess of NADH has a number of effects, including inhibiting, rather than stimulating fatty acid oxidation; inhibiting gluconeogenesis rather than stimulating it; inhibiting, rather than stimulating glycerophosphate dehydrogenase; and oring the formation of lactate rather than pyruvate from glycolysis (thereby increasing, rather than decreasing the lactate/pyruvate ratio;). Ref: Botham K.M., Mayes P.A. (2011). Chapter 12. Biologic Oxidation. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds),Harper's Illustrated Biochemistry, 29e.
Fatty acid oxidation is stimulated
Gluconeogenesis is stimulated
Glycerophosphate dehydrogenase is stimulated
The ratio of NADH to NAD+ is increased