Glucocoicoids act in inflammation mainly by
Glucocoicoid helps in induction of lipocoins in macrophages. Lipocoins inhibits phospholipase A2 enzyme present in the cell membrane and thus lead to decrease production of prostaglandins, Leukotriens which are responsible for inflammation. (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 279)
(downward arrow) Lipocoin
increasing IL-2
(upword arrow) Lipocoin
increasing CRP
Endocrinology