Which of the following inborn error of metabolism has porphyria like clinical features?
Succinylacetone accumulates in hereditary tyrosinemia type I (fumarylacetoacetate hydrolase deficiency). Succinylacetone is structurally similar to ALA and inhibits ALA dehydratase leading to porphyria like features.
Phenylketonuria
Tyrosinemia type I
Alkaptonuria
Metachromatic leukodystrophy
HAEM synth and porphyrias