Enzyme-deficient in lactic acidosis caused by thiamine deficiency is?
TPP is the coenzyme for oxidative decarboxylation of alpha-ketoglutaric acid.eg: pyruvate to acetyl CoAPolyneuritis: It is common in chronic alcoholics. Alcohol utilization needs large doses of thiamine. Alcohol inhibits intestinal absorption of thiamine, leading to thiamine deficiency. Polyneuritis may also be associated with pregnancy and old age. Such thiamine deficiency in alcoholism may cause impairment of conversion of pyruvate to acetyl CoA. This results in increased plasma concentration of pyruvate and lactate, leading to lactic acidosis.Ref: DM Vasudevan - Textbook of Biochemistry, 6th edition, page no: 392
Pyruvate dehydrogenase
Succinate thiokinase
Cis aconitase
Isocitrate dehydrogenase
vitamins