Which of the vitamin deficiency lead to lacticacidosis?
Thiamin "The role of thiamin diphosphate in pyruvate dehydrogenase means that in deficiency there is impaired conversion of pyruvate to acetyl CoA. In subjects on a relatively high carbohydrate diet, this results in increased plasma concentrations of lactate and pyruvate, which may cause life-threatening lactic acidosis."- Harper Biologically active form of Thiamin (vitamin B1) is Thiamin pyrophosphate or Thiamin diphosphate. Thiamin diphosphate is the coenzyme for 3 multi-enzyme complexes that catalyze oxidative decarboxylation reactions: a. Pyruvate dehydrogenase complex which conves pyruvic acid to acetyl CoA b. Alpha-ketoglutarate dehydrogenase complex in the citric acid cycle which conves alpha-ketoglutarate to succinyl CoA c. Branched-chain keto-acid dehydrogenase involved in the metabolism of leucine, isoleucine, and valine. Thiamin diphosphate is also the coenzyme for transketolase in the HMP pathway of glucose metabolism.
Riboflavin
Thiamin
Niacin
Panthotheic acid