A patient presents with cervical lymphadenopathy. Biopsy demonstrates a nodular lymphoma with follicle formation. This lesion would most likely be associated with which of the following?
Nodular lymphomas of all types are derived from the B-cell line. The translocation t(14, 18), with bcl-2 activation, is associated with these lymphomas. Must know: An abl-bcr hybrid and t(9, 22) translocation are associated with chronic myeloid leukemia (CML). c-myc activation and t(8, 14) are associated with Burkitt's lymphoma. Ref: Robbins Basic Pathology, 8th Ed, page 20-21;198-199
bcr-abl hybrid
bcl-2 activation
c-myc activation
t(8, 14)