What is implied if a drug has more clearance than the GFR?
The clearance of the substance equals the GFR if there is no net tubular secretion or reabsorption (Inulin), exceeds the GFR if there is net tubular secretion (PAH), and is less than the GFR if there is net tubular reabsorption (Glucose). Ref: Ganong 25th ed/page 679
Drug is reabsorbed in the tubules
Drug is secreted in the tubules
Drug is excreted in bile
Drug is neither secreted nor reabsorbed
Renal physiology