The form of THF used in treatment is :
N5 Formyl THFA/ Folinic acid has high stability so it is used therapeutically. Extra reading : N5 Formyl THFA/ Folinic Acid (5-formyl tetrahydrofolic acid or leucovorin) is necessary co-factor in the body (an essential B vitamin). Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. Uses : 1. to counteract the toxic effects of folic acid antagonists, such as methotrexate (inhibits DHFR) 2. in the treatment of megaloblastic anemias due to folic acid deficiency
N5 formyl THF
N5 methyl THF
N10 formyl THF
N5 formimino THF
Vitamins and Minerals