Drug with high plasma protein binding have
Ref-KDT 6/e p22 Plasma protein binding causes restriction of drugs in the vascular compament and thus lower volume of distribution. Longer duration of action - as the protein-bound fraction is not available for metabolism ofexcretion. Plasma protein bound drugs tend to have more drug internactions due to displacement of a drug with lower affnity by a drug ywith higher affinity for plasma proteins. Hypoalbuminemia can lead to high concentration of free drug and thus drug toxity.
Sho duration of action
Less drug interaction
Lower volume of distribution
All of the above
General anatomy