Cobble stone appearance is seen in:
Crohn's Disease Earliest gross pathologic lesion is a superficial aphthous ulcer noted in the mucosa. Linear ulcers may coalesce to produce transverse sinuses with islands of normal mucosa in between (cobblestone appearance) Characteristic histologic lesions of Crohn's disease are noncaseating granulomas with Langerhan's giant cells.
Ulcerative colitis
Crohn's disease
Appendicitis
Carcinoma rectum
Inflammatory bowel disease