Destruction of fat in acute pancreatitis is due to
Pathophysiology AP is the final result of abnormal pancreatic enzyme activation inside acinar cells Colocalization hypothesis: Cathepsin B-mediated intra acinar cell activation of the digestive enzymes leads to acinar cell injury and triggers an Inflammatory response Digestive enzymes are released which consists of trypsin and lipase which is responsible for the digestion of fat in acute pancreatitis Ref: Sabiston 20th edition Pgno :1524-1528
Lipase and trypsin
Secretion
Lipase and elastase
Cholecystokinin and trypsin
G.I.T