The detection rate of Down syndrome with first-trimester screening with NT, PAPP-A, and hCG is
Selected Down Syndrome Screening Strategies and Their Detection Rate: Screening test Detection rate Quadruple screen 80-82% First-trimester screen NT alone 64-70% NT, hCG, PAPP-A 80-84% Integrated screening 94-96% Sequential screening Stepwise 92% Contingent 91% Cell-free DNA 91%
64-70%
80-84%
94-96%
99%
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