HPV causes which change in cervical epithelium ?
Ans. is 'c' i.e., Immoalization of epithelial cells HPV selectively infects the epithelium of skin and mucous membrane and may immoalize the keratinocytes leading either asymptomatic infection, or was or neoplasia.Products of E-genes (E6, E7) are related to immoalization or malignant transformation of keratinocytes by interfering with p53 and Rb genes, respectively.
Induction of apoptosis
Induction of necrosis
Immoalization of epithelial cells
By stimulating telomerase