Most common cause of hereditary spherocytosis:
Most common cause of hereditary spherocytosis is ankyrin gene mutation. Ankyrin is the principal binding site for spectrin on the red cell membrane. Mutations of alpha-spectrin are associated with recessive forms of HS, whereas mutations of beta-spectrin occur in families with autosomal dominant forms of HS.
Spectrin
Glycophorin
Ankyrin
Band 4