Which of the following is not seen on hemoglobin electrophoresis in sickle cell anemia
Ref Harrison 19 th ed pg 634 sickle cell syndromes are caused by a mutation in the b-globin gene that changes the sixth amino acid from glutamic acid to valine. HbS (a2 b2 6 Glu-Val) polymerizes reversibly when deoxygenated . No beta chains and therfther no HbA
HbA
HbA2
HbF
HbS
Haematology