Xeroderma pigmentosum is characterized by
Xeroderma pigmentosum is a genetically determined disorder, in which defective DNA repair mechanisms lead to chronic UV damage and subsequent development of different sun related skin tumors, including melanoma, in sun exposed areas.
AutosomaL dominant inheritance
Inability to repair sunlight induced damage to DNA
Irregular accumulation of melanin in the basal cell layer
Acanthosis of epithelium with elongation of rete ridges