Rifampicin is a powerful enzyme inducer. It is most likely to induce the metabolism of which of the following anti-retroviral drugs?
Rifampicin is a microsomal enzyme inducer - increases several CYP450 isoenzymes, including CYP3A4 , CYP2D6, CYP1A2 and CYP2C subfamily. It thus enhances its own metabolism as well as that of many drugs including warfarin, oral contraceptives, coicosteroids, sulfonylureas, HIV protease inhibitors, non-nucleoside reverse transcriptase inhibitors (NNls), theophylline, metoprolol, fluconazole, ketoconazole, clarithromycin, phenytoin, etc. Among given options, Nevirapine (NNI) is the best answer.
Tenofovir
Nevirapine
Abacavir
Zidovudine
Mycobacterial Diseases (TB, Leprosy and MAC)