Nitrogylerine is effective when admistered sublingually because it is
Nitroglycerin is effective when retained sublingually because it is non inonized and has very high lipid solubiility.thus the drug is absorbed very quickly Refer KDT 7th/e P6
Non ionized and lipid soluble
Ionized and lipid soluble
Non ionized and water insoluble
Ionized and water water insoluble
General anatomy