Giant Papillary Conjunctivitis is caused by –
Giant papillary conjunctivitis
It is conjunctivitis characterized by the formation of giant papillae. It occurs most probably due to mechanical irritation of the palpebral conjunctiva in cases of :-

Contact lenses
Artificial eyes
Prominent suture following surgery
Contact Lens wear
Ocular Prosthesis
Protruding corneal sutures
All of the above