Mechanism of action of Temozolomide is :
Temozolomide is an alkylating agent . It is the drug of choice for brain tumors.Other alkylating agents are:* If: Ifosfamide* Bus: Busulfan* Not: Nitrosoureas* Present: Procarbazine* Take: Temozolamide* My: Mephalan, Mechlorethamaide* Cycle: CyclophosphamideTopoisomerase inhibitor is Etoposide.Microtubule inhibitors are Vincristin, Vinblastin.Proteosome inhibitors are Boezomib.
Alkylation of DNA
Inhibition of topoisomerase
Microtubule inhibition
Proteasome inhibition
JIPMER 2018