All of the following statements regarding penicillin-G are true, EXCEPT:
Penicillin G is acid labile and it is destroyed easily by gastric acid, and hence it can only be given parenterally (intravenously or intramuscularly) and not orally. Ref: KDT, 6th Edition, Pages 696-97 ; Streptococcal Pharyngitis: Optimal Management By Jean Claude Pechere, 3rd Volume, Page 188 ; Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk By Gerald Briggs, Roger K. Freeman, Sumner J. Yaffe, Page 205
Can be given orally
Active against gram positive organisms
Probenecid given along with penicillin-G increases its duration of action
Acts by inhibition of cell wall synthesis