A person with prolonged usage of contact lenses presented with irritation of left eye. A diagnosis of keratitis was made and corneal scrapings revealed growth of multidrug resistant pseudomonas aeroginosa. Which of the following, best explains the mechanism of antimicrobial resistance in these isolated pseudomonas aeroginosa strains?
Pseudomonas aeruginosa and streptococcus pneumoniae are common nosocomial pathogens well known for their ability to aggregate and form biofilms. Cells which form biofilm are not susceptible to host immunity. If a microbe successfully forms a biofilm, it will be biocide-resistant and hence highly virulent. Ref: Contact Lens Practice By Nathan Efron, 2002, Chapter 39; Biofilm Eradication and Prevention : A Pharmaceutical Approach to Medical Device Infections, Page 69, 177; Textbook of Ophthalmology By Sunita Agarwal, Athiya Agarwal, David J Apple, 2002, Pages 216, 1007; Microbiology By Richard A. Harvey, Pamela C. Champe, Bruce D. Fisher, William A. Strohl, 2nd Edition, Page 139
Improper contact lens hygiene
Ability of Pseudomonas to produce biofilms
Frequent and injudicious use of topical antibiotics
Ability to transfer resistance genes from adjacent commensal flora