A female suffering from psychosis, taking phenothiazine's now complains of sudden onset of high grade fever, muscle rigidity and altered sensorium. The diagnosis is :
Ans. is 'b' Neuroleptic malignant syndrome History of intake of antipsychotic drugs and high grade fever, muscle rigidity, altered sensorium suggests Neurolept Malignant Syndrome.Neurolept Malignant SyndromeUsually occurs in patients who are extremely sensitive to extrapyramidal effects of antipsychotics.C/F:Marked muscle rigidity *High fever*Increase CPK*Autonomic instability*Severe extrapyramidal syndromes*TreatmentVigorous treatment with antiparkinson drugsDiazepamDantroline*Bromocriptine*
Malignant hyperthermia
Neuroleptic malignant syndrome
Tardive dyskinesia
Akathesia
Anti-Psychotic