Activated protein C inhibit clotting mechanism by inactivating which of the following clotting factors:
Protein-C is a vitamin K-dependent protease that requires a cofactor (Protein S). Activated Protein C/protein S forms a complex which is a potent inhibitor of coagulation factors Va and Factor VIIIa. Protein C acts as a Tissue factor pathway inhibitor (TFPI)
Factor IIIa and Factor VIIIa
Factor VIIIa and Factor IXa
Factor Va and Factor VIIIa
Factor Va and Factor VIIa
Clotting system