Which of the following group of antibiotics possess additional anti inflammatory and immunomodulatory activities ?
Tacrolimus is a macrolide antibiotic, it acts by inhibiting cytokine production. It possess anti-inflammatory and immunomodulatory activities. Mechanism: Tacrolimus binds to FKBP 12 and forms a complex. This then binds to calcineurin and inhibits calcineurin phosphates activity. Because of this it cannot dephosphorylate NFATc, and prevents its migration into nucleus and activation of cytokines. Ref: Immunopharmacology By Manzoor M. Khan, Pages 91-3
Tacrolimus
Polypeptide antibiotics
Fluoroquinolones
Macrolides