Which of the following statement about Schilling's test is false?
In the Schilling test, 58Co-labeled cobalamin is administered orally, and urine is collected for 24 h. The test is dependent on normal renal and bladder function. Urinary excretion of cobalamin reflects cobalamin absorption, provided that intrahepatic binding sites for cobalamin are fully occupied. To ensure saturation of these binding sites so that all absorbed radiolabeled cobalamin will be excreted in urine, 1 mg of cobalamin is administered intramuscularly 1 h after ingestion of the radiolabeled cobalamin. The Schilling test may yield an abnormal result (usually defined as <10% excretion in 24 h) in pernicious anaemia, chronic pancreatitis, blind loop syndrome, and ileal disease. ref - harriosn's internal medicine 20e pg 2251, 2323t
Abnormal in pernicious anemia
The test is dependent on normal renal function.
Abnormal in ileal disease
58Co-labeled cobalamin is administered intramuscularly
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