Co-translational inseion is seen with
The signal hypothesis states that protein is inseed into ER membrane at the same time its mRNA being translated on polyribosomes known as " co-translational inseion ". This is translocation endoplasmic reticulum. Components: N terminal signal peptide: Polyribosomes SRP SRP-R Sec 61 translocon TRAM TRAP proteins Reference: Harper; 30th edition
Translocon
Chaperons
Ubiquitin
Mannose 6- P
Structure and function of protein