GTN is given sub-lingually, why?
Ans: a (To avoid first pass metabolism) Ref: Goodman & Gilman, 11th ed, p. 3SUBLINGUAL ADMINISTRATIONVenous drainage from the mouth is to the superior vena cava, which protects highly soluble drugs like nitroglycerin from rapid hepatic first-pass metabolism. If a tablet of nitroglycerin were swallowed, the accompanying hepatic metabolism would be sufficient to prevent the appearance of any active nitroglycerin in the systemic circulation.
To avoid first pass metabolism
Rapid effect
Gastric irritation
To avoid side effects
C.V.S