Which is related to sunlight exposure
A i.e. Actinic Keratosis Etiological Factors & Premalignant lesions for Squamous Cell CA Actinic (Solar) KeratosisQ, Arsenic (As) Keratosis Bowen's diseaseQ (Intra-epidermal epithelioma) Chemical carcinogens eg. tar, pitch, Arsenic DLEQ, Dystrophic epidermolysis bullosa Erythema ab igne (persistent heat injury) Erythroplasia of queyratQ (Bovven's ds. of glans penis) Epidermal naevus Epidermodysplasia verruciformis Giant way tumor of genitalia, Genodermal disease (i.e. Xeroderma)Q Hyperophic lichen planusQ Human Papilloma virus infection (more commonly in immunosuppressed renal transplant patients) Xeroderma pigmentosa (Genodermal disease)Q UV radiation - UV-BQ Actinic/ Solar Keratosis (AK) These are hyperkeratotic lesions that develop in response to prolonged exposure to ultraviolet radiation (i.e. on chronically light exposed adult skin)Q. Risk factors for development of AK include old age, male gender, fair skin that easily burns and freckles, blond/red hair, light colored eyes, immunosuppression, gentic syndromes (like XP, Bloom's and Rothmund-Thomoon syndromes), prior history of AK or other skin cancer and most impoantly cumulative /IV radiation exposureQ. - Historically being considered premalignant lesionsQ with focal areas of abnormal proliferation and differentiation that carry a low risk (0.2%) of progression to invasive sauqmous cell carcinomaQ. However, now these are defined as malignant neoplasm with intra epithelial SCCs in evolution. - It is raised, pink or grey, scaling or way hyperkeratotic plaque or papule with alternating parakeratoses & hyperkeratosis in histology. Premalignant lesion Predisposed Cancer Actinic (Solar) KeratosisQ Squamous cell carcinoma Bowen's ds. (intra-epidermal- epithelioma)Q Squamous cell CA ErythroplasiaQ of QueyratQ (bowen's ds. affecting glans penis) Squamous cell CA Lan ago maligna (Hutchinson's freckle)Q Malignant Melanoma Also Know -UV - radiation & Xeroderma pigmentosa are risk factors for all 3 types of skin cancer (Basal, Squamous Cell, & Melanoma). Lentigo maligna (Hutchinson's freckle) is premalignant lesion for malignant melanomaQ.
Actinic keratosis
Molluscum contagiosum
Icthyosis
Basal cell carcinoma