Zileuton, a 5-lipooxigenase inhibitor, acts by which of the following mechanisms?
Ans. d (All of the above) (Ref. KDT, Pharmacology, 6th ed. 175, 223)ZILEUTON# 5-Lipoxygenase inhibitor and blocks LTC4, LTD4 as well as LTB4 Synthesis# Duration of action - Short 3-4 hrs# Adverse effect - Hepatotoxicity.MONTELEUKAST, ZAFIRLUKAST# Cys LT1 receptor antagonist used in asthma prophylaxis# Side effects:- Eosinophilia, Neuropathy, Churg-Strauss disease
LT C4 synthesis inhibitor
D4 synthesis inhibitor
LT B4 synthesis inhibitor
All of the above
Asthma