Hepatitis can be a complication of ......
Metabolic byproduct of halothane can cause autoimmune hepatitis. Halothane hepatitisis rare with an incidence of 1 per 35,000 cases but very fatal, with amoality of 50-75%. It is an immune mediated due to antibodies against highly reactive trifluoroacetyl chloride which is a metabolite of halothane. Risk factors for halothane hepatitis: Multiple exposures to halothane at sho intervals middle-aged obese women - because halothane undergo extensive metabolism in obese patients familial predisposition to halothane Another theory for halothane hepatitis is that it is caused by a hypersensitivity reaction associated with oxidative metabolism of halothane. The liver in halothane hepatitis shows centrilobular necrosis. In a patient with prior history of halothane hepatitis, inhalational induction agent of choice is Sevoflurane. Other points related to effect of halothane on hepatic system : Disrupts dual blood supply of liver ( Among all volatile anesthetic agent , it cause max decrease in hepatic flow) Contraindicated in Pre-existing liver days function C/I in hepatic surgery
Halothane
Enflurane
Methoxyflurane
Enflurane
Inhalational Anesthetic Agents