Family of Toll-like receptors (TLRs) are?
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.They are the Most impoant receptors for microbial products to initiate acute inflammation. Ref - Harrison's internal medicine 20e p1067,2511
Most impoant for oncogene activation by virus and plays impoant role in cancer
Essential for glucose homeostasis
Most impoant for entry of retrovirus into the immune cells
Most impoant receptors for microbial products to initiate acute inflammation
Immune system