Which of the following is typical of apoptosis?
Apoptosis is characterized by the activation of endonucleases, which leads to DNA fragmentation. The chromatin of apoptotic nuclei appears clumped as inpyknosism, but karyolysis does not occur. Nuclei may become fragmented, but this fragmentation is distinct from the mitotic division. Apoptosis does not induce an influx of inflammatory cells, and the dead cell fragments are taken up by adjacent cells in the tissue itself. Similar to other forms of cell death, apoptosis is associated with an influx of calcium into the cytosol.
Activation of DNA synthesis, as in the mitotic cycle
Activation of endogenous endonucleases
Reduced cytosolic free calcium
Karyolysis
General pathology