Mediator of acute inflammation not derived from the cell is (D. REPEAT Feb 2014)
Chemical Mediators of Inflammation
Aka permeability factors or endogenous mediators of increased vascular permeability.
They are broadly classified into 2 groups:
i. Mediators released by cells.
ii. Mediators originating from plasma.
Chemical Mediators of Acute Inflammation
A. Cell-Derived Mediators
1. Vasoactive amines

Histamine
5-hydroxytryptamine
Neuropeptides

2. Arachidonic acid metabolites (Eicosanoids)
i. Metabolites via cyclo-oxygenase pathway

Prostaglandins
Thromboxane A2
Prostacyclin
Resolvins

ii. Metabolites via lipo-oxygenase pathway

5-HETE
Leukotrienes
Lipoxins

3. Lysosomal components (from PM Ns, macrophages)
4. Platelet-activating factor (PAF)
5. Cytokines

IL-1
TNF-α
TNF-β
IFN-γ
Chemokines

6. Free radicals

Oxygen metabolites
Nitric oxide

B. Plasma-Derived Mediators (Plasma Proteases) Products of:
1. The Kinin system.
2. The Clotting system.
3. The Fibrinolytic system.
4. The Complement system.
Histamine
Kinins
Leukotrienes
Cytokines