LCAT deficiency increases the following
* HDL is synthesized and secreted from both liver and intestine * Lecithin:cholesterol acyltransferase (LCAT) activity is associated with HDL containing apo A-I. * As cholesterol in HDL becomes esterified, it creates a concentration gradient and draws in cholesterol from tissues and from other lipoproteins thus enabling HDL to function in reverse cholesterol transpo * Absence of LCAT leads to block in reverse cholesterol transpo. HDL remains as nascent disks incapable of taking up and esterifying cholesterol. Ref:- Harper 30/e; pg num:- 249, 272
Chylomicrons
IDL
VLDL
HDL
Metabolism of lipid