Mechanism of action of Clomiphene Citrate is:
Clomiphene citrate binds to both Estrogen receptors (ER a and B) and acts as a pure estrogen antagonist, in all human tissues. It induces the Gn secretion in women by blocking estrogenic feedback inhibition of pituitary which inturn increases the amount of LH and FSH released at each secretory pulse and results in ovulation. Ref: KDT, 6th Edition, Page 303 ; Essentials of Medical Pharmacology By K D Tripathi, 4th Edition, Page 278
Binds to estrogen receptors and causes negative feedback at hypothalamus
Binds estrogen receptors and prevents negative feed back at hypothalamus
Binds to progesterone receptors
Progesterone agonist