The positive inotropic effect of digitalyzers is due to invitation of Na+/K+ ATPase pump in cardiac muscle cell membrane leading to
Ref-Goodman and Gillman 12/e p802,803 The positive inotropic effect of digitalis is due to inhibition of Na+/K+ ATPase pump in cardiac muscle cell membrane leading to decreased activity of Na+/Ca++ exchanger causing decrease the influx of sodium and decreased efflux of CA++ in the sarcolemma
Decrease the activity of Na+/Ca+ exchanger causing decrease the influx of sodium and decreased efflux of Ca++ in the sarcolemma
Decreased efflux of Na+ leading to less negative resting membrane potential and opening of voltage gated Ca+ + channels on the T tubules
Increased intracellular Na+ causing increased efflux of any place and increase the influx of Ca + + through Na+/ Ca + + exchanges in sarcolemma
Increased intracellular Na+ decreasing the activity of Ca + + pump in the sarcoplasmic reticulum
Cardiovascular system