In tumor lysis syndrome following electrolyte abnormalities are seen:
Tumor Lysis Syndrome:Tumor with very high rate of growth- during chemotherapy there will be rapid destruction of the cells that will lead to Tumor Lysis Syndrome. It releases: K+-Hyperkalemia PO42-Hyperphosphatemia Hypocalcemia:Ca2+sequestration by PO42. Hyperuricemia:Nucleic Acid Break down. | can lead to AKI Can prevent/ Tx with aggressive hydration, alopurinol and rasburicase. Common tumors associated with Tumor lysis syndrome - ALL, Burkitt's Lymphoma.
Hyperuricemia, Hyperphosphatemia, Hyperkalemia
Hypocalcemia, Hypokalemia, Hyponatremia
Hypercalcemia, Hyperkalemia, Hyperphosphatemia
Hypophosphatemia, Hypokalemia, Hypocalcemia
DNB 2018