All of the following are true regarding ifosfamide EXCEPT:
Ifosfamide belongs to the group of medicines called alkylating agents. Ifosfamide injection is used in combination with other medicines to treat cancer of the testicles. This congener of cyclophosphamide has a longer and dose-dependent tllz. It has found utility in bronchogenic, breast, testicular, bladder, head and neck carcinomas, osteogenic sarcoma and some lymphomas. The dose limiting toxicity of ifosphamide is haemorrhagic cystitis. To prevent the same mesna is routinely given with it. Mesna is a -SH compound that is excreted in urine--binds and inactivates the vasicotoxic metabolites of ifosfamide and cyclophosphamide. Ifosfamide causes less alopecia and is less emetogenic than cyclophosphamide. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:822
Metabolised by cytochrome p450 enzymes
Less neurotoxic than cyclophosphamide
Chloracetaldehyde is the metabolite of ifofamide
It is a nitrogen mustard
Chemotherapy