Absolute contraindication to thrombolytic therapy is
Ans. b (History of hemorrhagic stroke in past one year). (Ref. Harrison's Medicine - 18th/Table 370-1).Thrombolytic therapyIndicationContraindicationClinical diagnosis of strokeOnset of symptoms to time of drug administration 3 hCT scan showing no hemorrhage or edema of >1/3 of the MCA territoryAge 18 yearsConsent by patient or surrogateSustained BP >185/110 mm Hg despite treatmentPlatelets <100,000; HCT <25%; glucose <50 or >400 mg/dLUse of heparin within 48 h and prolonged PTT, or elevated INRRapidly improving symptomsPrior stroke or head injury within 3 months; prior intracranial hemorrhageMajor surgery in preceding 14 daysMinor stroke symptomsGastrointestinal bleeding in preceding 21 daysRecent myocardial infarctionComa or stupor
Pregnancy
History of hemorrhagic stroke in past one year
Patients on nitrates
Hypertension
Hematology