A 19-year-old female presented with fever, cough shoness of breath and diffuse chest pain. She gave a history of reduced water intake since yesterday. On examination, Hypeension Tachycardia SpO2 is 80% on room air B/L wheezing in lower lung zones Lab findings revealed anemia, leukocytosis, reticulocytosis, thrombocytosis, increased serum bilirubin. Peripheral blood smear Chest x-ray CT scan of chest Which is the most appropriate therapy in the above condition: -
This is a case of acute chest syndrome in a patient of sickle cell anemia. Presents as acute fever, cough, chest pain and wheezing in a background of sickle cell anemia. X-ray and CT are suggestive of subsegmental atelectasis of right lower lobe. Management: - Transfusion to maintain hematocrit > 30% Emergency exchange transfusion Hydroxyurea is the mainstay.
Hydroxyurea
Sildenafil
IV ceftriaxone
Streptokinase
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