The main enzyme responsible for activation of xenobiotics is
Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in target tissue metabolic activation of xenobiotic compounds. They may also determine drug efficacy and influence the tissue burden of foreign chemicals or bioavailability of therapeutic agents.
Cytochrome P - 450
Glutathione S - transferase
NADPH cytochrome P - 450 reductase
Glucoronyl transferase
Enzymes