All are true regarding superantigens except?
Superantigens activate very large number of T cells. NON -MHC restricted They are medium sized proteins which Attach to TCR on lateral side on Vb (Variable) domain, outside the antibody binding groove. They cause release of cytokines that induce >20% of T lymphocytes activation resulting in massive proliferation of T lymphocytes. They have high resistance to proteases.
Activate very large numbers of B cells
Bind outside the antibody binding groove
Are medium sized proteins
Cause release of cytokines
Immunology Pa 2 ( Hybridoma Technology, Complement Pathways, Interferon, Structure and Functions of Immune Cells )