Bullous disease in which autoantibodies are formed against antigens of epidermal intercellular junctions
Bulla development in pemphigus vulgaris is due to Acantholysis, this is disruption of intercellular attachment leading to intraepidermal bullae. Autoantibodies against desmosomal protein-desmoglein-3 mediate the pathogeneis.
Pemphigus Vulgaris
Epidermolysis bullosa
Dermatitis herpatitis
Bullous pemphigoid