All of the following are seen in follicular carcinoma of thryoid, except:
Genetics of follicular thyroid carcinomas: 30% to 50% of follicular carcinomas harbor RAS mutation. 20% to 50% of follicular carcinomas harbor PAX8-PPARG fusion. Up to 10% of follicular carcinomas exhibit gain-of-function mutations of PIK3CA (the gene that encodes phosphoinositide 3-kinase ) or loss-of-function mutations of PTEN, a tumor suppressor gene and negative regulator of PI3K pathway. Point mutations of TP53, beta-catenin (CTNNB1), and TE are seen in poorly differentiated and anaplastic carcinomas.
PAX8-PPARG fusion
RAS gene mutations
Point mutations of TP53
Loss-of-function mutations of PTEN gene
Thyroid Tumor