Mechanism of action of aminophylline in bronchial asthma:
Aminophylline and other methylxanthines act byInhibiting phosphodiesterase enzyme causing - cAMPBlocking adenosine receptorsReleasing Ca2+ from sarcoplasmic reticulum in cardiac and skeletal muscles.Use-Asthma, COPD, chronic bronchitis
Decreasing phosphodiesterase activity
Direct action on smooth muscles
Releasing catecholamines
Stabilizing membrane of mast cells
A.N.S.