Substrate-level phosphorylation seen in reaction catalysed in
5th Step of TAC CYCLE: Generation of Succinate The next reaction involves a substrate level phosphorylation whereby a high energy phosphate is generated from the energy trapped in the thioester bond of succinyl CoA. The enzyme is succinate thiokinase (step 5, Fig.18.2). A molecule of GDP is phosphorylated to GTP and succinate is formed. The GTP can be conveed to ATP by reacting with an ADP molecule: GTP + ADP - GDP + ATPRef: DM Vasudevan Textbook of Medical Biochemistry, 6th edition, page no: 218
Succinate dehydrogenase
Alfa-ketoglutarate dehydrogenase
Succinyl CoA thiokinase
Malate dehydrogenase
Respiratory chain