Diazoxide acts by -
Ans. is 'b' i.e., Inhibiting insulin release Diazoxide inhibits insulin release from P-cells and causes hyperglycemia. o Its action on ATP sensitive IC channel is opposite to that of sulfonylureas --> opening (activation) of IC channels --> Hyperpolarization --> inhibition of insulin release. o Other actions which contribute to hyperglycemia a) peripheral utilization of glucose b) Release of catecholamines It is used in insulinoma.
Increasing insulin release
Inhibiting insulin release
Inhibiting insulin release
Inhibiting glucagon release