Which of the following provides the best explanation for neostigmine being preferred over physostigmine for treating Myasthenia gravis
Ref-KDT 6/e p103 Neostigmine is a quaternary ammonium derivative and is lipid insoluble. Its absorption from GIT penetration in the brain and cornea is much less than physostigmine . It produces additional action on NM receptor
It is better absorbed orally
It has longer duration of action
It is the additional direct on agonistic action on nicotinic receptor in the muscle end plate
It Penetrates blood brain barrier
Other topics and Adverse effects