Which of the following antimicrobial is effective against an organism producing extended spectrum beta lactamase?
Ans. (C) Piperacillin-tazobactam(Ref: Harrison 18th/1247)Organisms producing ESBL-like Klebsiella are resistant to most beta-lactams except carbapenems.ESBL can be inhibited by beta lactamase inhibitors.Amoxicillin is not effective against Klebsiella whereas piperacillin has wide spectrum including Klesiella.
Amoxicillin-Clavulinic acid
Cefepime
Piperacillin-Tazobactam
Ceftriaxone
Chemotherapy: General Principles