What is involved in the formation of d-TMP from d-UMP?
The following reaction is catalyzed by thymidylate synthetase:5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMPBy means of reductive methylation, deoxyuridine monophosphate (dUMP) and N5, N10-methylene tetrahydrofolate together used to form dTMP, yielding dihydrofolate as a secondary product.
N5, N10-methylene tetrahydrofolate
Form imino folate
N5 formyl folate
Dihydro folate
Metabolism of nucleic acids