All are true regarding reticuloendothelial system, EXCEPT:
At the end of the life span, the red cell is recognized as senescent by the cells of the reticuloendothelial (RE) system, and the cell undergoes phagocytosis. Once within the RE cell, the hemoglobin from the ingested red cell is broken down, the globin and other proteins are returned to the amino acid pool, and the iron is shuttled back to the surface of the RE cell, where it is presented to circulating transferrin. The formation of bilirubin occurs in reticuloendothelial cells and its fuher metabolism takes place in hepatocytes and excreted into the intestine. Also know: The reticuloendothelial system comprises, Monocyte-derived phagocytic cells (Kupffer cells) Ito cells in the liver Alveolar macrophages in the lungs Macrophages and dendritic cells in the spleen Mesangial cells in the kidneys Microglia in the brain Macrophages and dendritic cells in the lymph nodes Macrophages are long-lived phagocytic cells capable of many of the functions of neutrophils. They are also secretory cells that paicipate in many immunologic and inflammatory processes distinct from neutrophils. Ref: Gallin J.I. (2012). Chapter 60. Disorders of Granulocytes and Monocytes. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.
Antibody production
Destruction of RBCs
Bilirubin metabolism
Phagocytosis