The therapeutic efficiency of antihypeensive drugs is blunted by NSAIDs because they
PG E2 and PGI2 cause renal vasodilatation, natriuresis and increased water clearance due to inhibition of the action of ADH. Loop diuretics act paly by increasing the stimulation of cox. therefore NSAIDs attenuate the diabetic action of these drugs. Refer kDT 6/e p708
Cause of sodium excretion
Increase the clearance of anti Hypeensive drugs
Decrease the absorption of antihypeensive drugs
Decrease the synthesis of Vascular prostacyclin
Autacoids