All of the following are true regarding adverse effects of chlorpropamide except: March 2010
Ans. B: Less incidence of hypoglycemia Chlorpropamide is a long-acting sulphonylurea. It has more side effects than other sulphonylureas and its use is no longer recommended. Like other sulphonylureas, chlorpropamide acts to increase the secretion of insulin, so it is only effective in patients who have some pancreatic beta cell function. It can cause relatively long episodes of hypoglycemia; this is one reason why shoer-acting sulfonylureas such as gliclazide or tolbutamide are used instead. The risk of hypoglycemia makes this drug a poor choice for the elderly and patients with mild to moderate hepatic and renal impairment. Chlorpropamide and other sulphonylureas encourage weight gain, so they are generally not ored for use in very obese patients. Metformin is considered a better drug for these patients. Sulfonylureas should be avoided in patients with hepatic and renal impairment, patients with porphyria, patients who are breastfeeding, and patients with ketoacidosis. Not indicated for patients more than 65 years of age. It may cause facial flushing after the ingestion of alcohol. It may increase secretion of antidiuretic hormone (ADH), which can lead to hyponatremia.
Sensitizes the kidney to ADH action
Less incidence of hypoglycemia
More incidence of weight gain
Disulfiram like reaction may occur