Schilling Test is Abnormal in-
Ans. is 'a' i.e., Intrinsic factor deficiency Schilling testStep 1o Administer an intramuscular injection of Vitamin B12This will saturate the vitamin B12 receptors because otherwise the body would be hungry-' for the oral dose of vitamin B12 and radiolabelled vitamin B12 will not appear in urine even if there is no abnormalityt in vitamin B12 absorption.Step 2o Give a radiolabelled oral dose of vitamin B12If the vitamin BI2 absorption is normal the radiolabelled vitamin B12 would appear in the urine. In that case Vitamin B12 deficiency-> is believed to be due to dietarydeficiency.If the vitamin B12 does not appear in the urine malabsorption of Vitamin B12 is suspected. It has to be find out whether its due to pernicious anemia or some other cause.Step 3o Now adminster intrinsic factor along with radiolabelled Vitamin BI2If vitamin B12 apears in the urine then the diagnosis is pernicious anemia.If the Vitamin B12 still does not appear in the urine then it is a case of malabsorption but not due to pernicious anemia and most commonly due to ileal resection or small bowel infection and bacterial overgrowth.
Intrinsic factor deficiency
Amylase deficiency
Lipase deficiency
Pancreatic insufficiency
Disorder of Absorption