Bleomycin toxicity affects which type of cells:
Ans. (A) Type I pneumocytes(Oncologic Emergencies by Sai Citing p92)Bleomycin causes necrosis of Type I pneumocytes that results in compensatory hyperplasia of type-II pneumocytes. Same kind of injury can also occur in response to radiations. In experimental models, this type of injury has been ameliorated by keratinocyte growth factor.
Type-I pneumocytes
Type-II pneumocytes
Endothelial cells
Pulmonary alveolar macrophages
Chemotherapy: General Principles