Esmolol is a sho acting b blocker because
* Esmolol - Shoest acting b blocker * Nadolol - Longest acting b blocker * Esmolol is metabolized by pseudocholinesterase hence it is sho acting. * Drugs metabolized by pseudocholinesterase SUCCINYLCHOLINE ESMOLOL REMIFENTANIL
It has more plasma protein binding
Its plasma hydrolysis by esterases is rapid
It has high lipid solubility
It has high oral bioavailability
Sympathetic System