All of the following are features of Goodpasture syndrome, except:
Goodpasture syndrome Uncommon autoimmune disease in which kidney and lung injury are caused by circulating autoantibodies. Most common in 2nd & 3rd decades of life. Anti-GBM antibody-mediated disease Goodpasture syndrome applies to the 40% to 60% of patients with these autoantibodies who develop pulmonary hemorrhage in addition to renal disease. Characterized by linear deposits of IgG and, in many cases, C3 in the GBM. The antigen common to the alveoli and GBM is a peptide within the noncollagenous poion of the a3 chain of collagen type IV (COL4A3).
Antibody to alpha-3 chain of type IV collagen (COL4A3)
Glomerular basement membrane is involved
Pulmonary haemorrhage
Subendothelial IgG deposits in renal biopsy
Nephritic Syndrome