According to Fick's law of diffusion, paicle flux will decrease if there is an increase in the:
According to Fick's law of diffusion, paicle flux is inversely propoional to the thickness of the membrane and directly propoional to the area of the membrane, the concentration difference across the membrane, and the diffusion coefficient. The diffusion coefficient depends on the physical propeies of the paicle and the membrane through which it is diffusing. In general, the larger the diameter of the paicle, the slower the rate of diffusion. Increasing temperature will increase the rate of diffusion. Ref: Katzung B.G. (2012). Chapter 1. Introduction. In B.G. Katzung, S.B. Masters, A.J. Trevor (Eds), Basic & Clinical Pharmacology, 12e.
Paicle's concentration difference across the membrane
Thickness of the Membrane
Area of the membrane
Temperature of the solution