A patient is admitted with 3rd episode of deep venous thrombosis. There is no history of any associated medical illness. All of the following investigations are required for establishing the diagnosis except :
Answer is C (Antibodies to factor VIII) Antibodies to factor VIII should be suspected in a disorder presenting with 'bleeding' and not in presenting with recurrent thrombosis. 'Antibodies against factor VIII should be suspected in any acquired severe bleeding disorder associated with a prolonged PTT' -- CMDT Factor VIII antibodies are distinguished from lupus anticoagulant by presence of clinical bleeding.' Major coagulation defects associated with venous thrombosis Factor V leiden (commonest association with DVT) Antithrombin III deficiency Protein C deficiency Protein S deficiency Prothrombin gene mutation Homocyteinemia Antiphospholipid antibody Homocyteinemia and Antiphospholipid antibodies are also associated with aerial thrombi (others being associated with venous thrombosis only).
Protein C deficiency
Antithrombin III deficiency
Antibodies to factor VIII
Antibodies to cardiolipin