Paget's disease is associated with _____:
Ans. C. Increase in bone turnoverPaget's disease is characterized by increased bone turnover with enlargement and thickening of the bone, but the internal architecture of new bone is abnormal and so the bone is unusually brittle.Paget's disease is also called osteitis deformans.It manifests in 4th and 5th decade Males.The pathologic process in Paget's disease is initiated by overactive osteoclastic bone resorption followed by a compensatory increase in osteoblastic new bone formation.The presence of inclusion bodies resembling paramyxovirus in the pagetic osteoclasts suggests that the viral infection may contribute to the clinical features of Paget's disease.This results in a structurally disorganized mosaic of woven and lamellar bone.The following radiological image of Paget's disease shows widened diploic space and there are ill-defined sclerotic and lucent areas throughout. The cortex is thickened and irregular.
Decrease in bone mineralization
Increased bone resorption
Increase in bone turnover
Increased degradation of collagen
Metabolic Bone Disease