Dose response curve of diazepam was produced alone and in the presence of flumazenil. Which of the following is true regarding the effect of flumazenil on the graph given below
Competitive antagonist decrease potency with no change in efficacy. The effect of antagonist (flumazenil) can be overcome by increasing the concentration of agonist(diazepam)
Decrease in Potency and no effect on efficacy
Decrease in Potency and decrease in efficacy
No effect on Potency and no effect on efficacy
No effect on Potency and decrease in efficacy
Sedative-Hypnotics and Parkinsonism