High titers of which of the following are considered to be highly specific for Systemic lupus erythematosus (SLE)?
A wide variety of autoantibodies can be seen in systemic lupus erythematosus, including all of those listed. However, high titers of anti-double-stranded DNA and anti-Sm (not listed above) are considered to be the most specific for systemic lupus erythematosus. MUST KNOW: Anti-Jo-1 is associated with inflammatory myopathies. Anti SS-A and anti-SS-B are associated with Sjogren syndrome. Ref: Costner M.I., Sontheimer R.D. (2012). Chapter 155. Lupus Erythematosus. In L.A. Goldsmith, S.I. Katz, B.A. Gilchrest, A.S. Paller, D.J. Leffell, N.A. Dallas (Eds), Fitzpatrick's Dermatology in General Medicine, 8e.
Anti dsDNA
Anti Jo-1
Anti SS-A
Anti SS-B