GNAS mutation is associated with malignancy of
GNAS encodes for alpha subunit of stimulatory G-protein , Gsalpha . Oncogenic activation of GNAS constitutively activates Gsalpha leading to Growth hormone(GH) adenomas. Ref: Robbins and cotrans 9e Pg 1076
Lactotrophs
Somatotrophs
Thyrotrophs
Coicotrophs
Endocrinology