True statement about ductus arteriosus is:
d. May cause a machinery murmur by its patency.(Ref: Nelson's 20/e p 497, Ghai 8/e p 413)Closure of ductus arteriosusPhysiological closure: occurs almost immediately after birth by contraction of muscular wall, mediated by bradykininAnatomic closure: occurs by proliferation of intima in 10-21 days; After obliteration, it forms ligamentum arteriosum. Note: Murmur due to PDA is classically referred to as a continuous machinery murmur.
It undergoes anatomic closure within 24 hours of birth
Forms the ligamentum venosum in later life
It is induced to close by high levels of prostaglandins
May cause a machinery murmur by its patency.
C.V.S.