There is mutation of gene coding for the ryanodine receptors in malignant hypehermia. Which of the following statements best explains the increased hea production in malignant hypehermia
Malignant hypehermia (MH) or malignant hyperpyrexia is a rare life-threatening condition that is usually triggered by exposure to ceain drugs used for general anesthesia -- specifically the volatile anesthetic agents and succinylcholine, a neuromuscular blocking agent. In susceptible individuals, these drugs can induce a drastic and uncontrolled increase in oxidative metabolism in skeletal muscleRef: Ganong&;s review of medical physiology; 24th edition; page no: 320
Increased muscle metabolism by excess of calcium ions
Thermic effect of food
Increased sympathetic discharge
Mitochondrial thermogenesis
Endocrinology