Action of physiological uncoupler ?
Ans. is 'b' i.e., Inhibition of ATP synthesis only not ETC As the name suggests, these componds block the coupeling of oxidation with phosphorylation. These compounds allow the transfer of reducing equivalents in respiratory chain but prevent the phosphorylation of ADP to ATP by uncoupling the linkage between ETC and phosphorylation. Thus the energy instead of being trapped by phosphorylation is dissipated as heat. Uncouplers may be :? i) Natural :- Thermogenin, thyroxine ii) Synthetic :- 2, 4-dinitrophenol (2, 4-DNP), 2, 4-dinitrocresol (2, 4-DNC), and CCCP (chlorocarbonylcyanidephenyl hydrazone).
Inhibition of both ATP synthesis and ETC
Inhibition of ATP synthesis only not ETC
Inhibition of only ETC not ATP synthesis
None of the above