Pethidine is pharmacologically different from morphine because it
Uses of opioids IV morphine Myocardial infarction, Acute pulmonary edema Codeine, Pholcodeine, Dextromethorphan, Noscapine Cough suppressants Loperamide, Diphenoxylate Noninfective diarrhea Morphine Pre-anesthetic medication Pethidine Reduces shivering after anesthesia ( a2 receptor action) Methadone Neuropathic / Cancer pain Methadone Opioid abuse & Opioid rotation treatment (Refer: K. D. Tripathi&;s Essentials of Medical Pharmacology, 7th edition, pg no: 475)
Causes more sedation
Causes more constipation
Has additional Anticholinergic action
Causes spasm of sphincter of Oddi
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