As per immunisation schdule, Hepatitis A vaccine is recommended at?
2 year REF: Nelson Textbook of Pediatrics 17th edition page 1178, WHO website: vaccines/en/hepatitisa.shtml Hepatitis A vaccines "Hepatitis A vaccine is recommended at 24 months of age in states and regions with an increased incidence of disease. A second dose is administered 6-12 months later to complete the series"' The vaccines are given parenterally, as a two-dose series, 6-18 months apa. Four vaccines are available commercially; three vaccines are manufactured from cell-cultureadapted HAV propagated in human fibroblasts (One vaccine is formulated without preservative; the other two are prepared with 2-phenoxyethanol as a preservative). The fouh vaccine is manufactured from HAV purified from infected human diploid cell cultures and inactivated with formalin. A combination vaccine containing inactivated hepatitis A and recombinant hepatitis B vaccines has been licensed since 1996 for use in children aged one year or older in several countries. The combination vaccine is given as a three-dose series, using a 0, 1, 6 month schedule. Hepatitis A vaccines are all highly immunogenic. Nearly 100% of adults will develop protective levels of antibody within one month after a single dose of vaccine. 99%-100% of vaccinated individuals had levels of antibody indicative of protection five to eight years after vaccination. Kinetic models of antibody decay indicate that the duration of protection is likely to be at least 20 years, and possibly lifelong.
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