The pathogenesis of hypochromic anemia in lead poisoning is due to
Lead interferes with the synthesis of Heme. Deficiency of heme causes microcytic hypochromic anemia because heme is an integral part of hemoglobin and it is well known that hemoglobin deficiency causes microcytic hypochromic anaemia.
Inhibition of enzymes involved in heme biosynthesis
Binding of lead to transferrin, inhibiting the transport of iron
Binding of lead to cell membrane of erythroid precursors
Binding of lead to ferritin inhibiting their breakdown into hemosiderin