Digoxin toxicity is precipitated by all except :
Hepatic disease Digoxin toxicity is enhanced by renal failure as it is excreted through kidneys where as digitoxin toxicity is enhanced by liver failure because it is eliminated by hepatic metabolism. Other factors precipitating Digitalis toxicity Advanced age Acute myocardial infarction or ischemia Hypoxemia Hypomagnesemia Renal insufficiency Hypercalceinia Electrical cardioversion Hypothyroidism Hypokalemia (most common precipitating cause of digitalis intoxication. This often occurs in patients with hea failure as a result of diuretic therapy and secondary hyperaldosteronism). ALSO REMEMBER The administration of following drugs raises the serum concentration of Digoxin by reducing both the renal and nonrenal elimination of digoxin and by reducing its volume of distribution. - Quinidine - Verapamil - Amiodarone - Propafenone
>Electrolyte disturbance
>Acute myocardial infarction
>Hepatic disease
>Renal disease