Hypersensitivity angitis is seen in -
Ans. is 'c' i.e., Henoch schonlein purpurao HSP is not hypersensitivity angitis. But the best answer amongst the given options is HSP because it is the most impoant differential of hypersensitivity angitis.Hypersensitivity angitis Hypersensitivity vasculitis or hypersensitivity angitis or leukocytoclastic angitis is a small vessel vasculitis due to hypersensitivity reaction.It is usually to a known drug, e.g. cefoperazone, autoantigens or infectious agents.Immune complexes lodge in the vessel wall, attracting polymorphoneuclear leukocytes who in turn release tissue-degrading substances leading to an inflammatory process.Hypersensitivity angitis usually present with skin manifestation, e.g. palpable purpura, but sometimes nerves, kidneys, joints and hea may also be involved.Diagnostic criteriao At least 3 out of the 5 criteria are requiredAge > 16Use of possible triggering drug in relation to symptoms.Palpable purpuraMaculopapular rashSkin biopsy showing neutrophil infiltrate around vessel.o Henoch-schonlein purpura is the most impoant differential.
SLE
Polyaeritis nodosa
Henoch schonlein purpura
Buergers disease