Which of the following is the most effective buffer for pH of 7.4?
Blood pH - 7.4 Buffer is most effective when pH = pKA +- 1 Therefore the most effective buffer for pH- 7.4 will be the one whose pKA +- 1 will cover this pH. Out of given options pKA +- 1 of phosphate buffer (5.9 to 7.9) covers pH 7.4. So most effective buffer for blood will be Phosphate buffer with pKA of 6.9.
Carbonic acid buffer with pKA-6.1
Phosphate buffer with pKA of 6.9
Glutamate buffer with pKA-8.7
Acetate buffer with pKa 4.5
JIPMER 2018