Which of the following inflammatory condition has 90% association with HLA-B27?
Ankylosing spondylitis (AS) is defined by the presence of sacroiliitis on X-ray and other structural changes on spine X-rays, which may eventually progress to bony fusion of the spine. There is a male-to-female ratio of about 3 : 1. In Europe, more than 90% of those affected are HLA-B27-positive (Caucasian HLA-B27 population prevalence is 9%). The overall prevalence of AS is below 0.5% in most populations. Over 75% of patients are able to remain in employment and enjoy a good quality of life. Even if severe ankylosis develops, functional limitation may not be marked, as long as the spine is fused in an erect posture. Ref Davidsons 23e p1030
Ankylosing spondylitis
Psoriasis
Reiters
Rheumatoid ahritis
Immune system