Which of the following is the best explanation for the mechanism of the action of the intrauterine device (IUD)?
The making of a sterile inflammatory reaction: Polymorphonuclear leukocytes, giant cells, plasma cells, and macrophages are seen in the endometrium after placement of an IUCD. Biochemical changes in the endometrium include changing levels of lysosomal hydrolases, glycogen deposition, oxygen composition, total proteins, acid and alkaline phosphatases, urea phospholipids, and RNA/DNA ratios. IUDs treated with copper and progesterone exe additional effects. Copper decreases in sperm motility and function with inability of the sperm to pass through the uterine cavity. Progesterones cause the endometrium to become atrophic and un receptive for an implantation, along with making the cervical mucus thick
Hyperperistalsis of the fallopian tubes accelerates oocyte transpo and prevents feilization
A subacute or chronic bacterial endometritis interferes with implantation
Premature endometrial sloughing associated with menorrhagia causes early aboion
A sterile inflammatory response of the endometrium prevents implantation
Contraceptives