Pilocarpine reduce the intraocular pressure in person with closed angle glaucoma by
Refer kDT 7/e p 156 It has also been used in the treatment of chronic open-angle glaucoma and acute angle-closure glaucoma It acts on a subtype of muscarinic receptor (M3) found on the iris sphincter muscle, causing the muscle to contract -resulting in pupil constriction (miosis). Pilocarpine also acts on the ciliary muscleand causes it to contract. When the ciliary muscle contracts, it opens the trabecular meshwork through increased tension on the scleral spur. This action facilitates the rate that aqueous humor leaves the eye to decrease intraocular pressure
Reducing aqueous humour secretion
Contacting iris spincter muscle
Increasing aqueous humour outflow
Relaxin ciliary muscle
Autonomic nervous system