Which of the following statement regarding first order kinetics is true?
According to first order kinetics of elimination the rate of elimination of a drug is directly propotional to the drug concentration. Clearence of the drug remains constant and a constant fraction of drug is eliminated in unit time. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 27-8
It is independent of plasma concentration
Tl/2 of the drug increases with dose
Clearance of the drug decreases with dose
A constant propoion of plasma concentration is eliminated