Which of the following is not true about PTEN gene?
PTEN (phosphatase and tensin homologue) Membrane-associated phosphatase encoded by a gene on chromosome 10q23 that is mutated in Cowden syndrome Autosomal dominant disorder C/F:- Marked by frequent benign growths, such as skin appendage tumors Increased incidence of epithelial cancers, paicularly of the breast, endometrium, and thyroid. PTEN acts as a tumor suppressor by serving as a brake on the PI3K/AKT arm of the receptor tyrosine kinase pathway. PTEN gene function is lost in many cancers through deletion, deleterious point mutations, or epigenetic silencing.
It is the membrane associated phosphatase
Encoded by gene located on chromosome 10q23
It is mutated in endometrial, breast, thyroid carcinoma
It acts as a proto-oncogene
Genetic Basics Of Carcinogenesis