Substance P belongs to the tachykinin family of peptides. Which of the following peripheral tissues contain substance P?
Substance P is found in high concentrations in the endings of primary afferent neurons in the spinal cord, and it is probably the mediator at the first synapse in the pathways for pain transmission in the dorsal horn. It is also found in high concentrations in the nigrostriatal system, where its concentration is propoional to that of dopamine, and in the hypothalamus, where it may play a role in neuroendocrine regulation. It is responsible for the axon reflex and in the intestine, it is involved in peristalsis. Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 7. Neurotransmitters & Neuromodulators. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.
Plasma cell
Mast cell
Nerve terminal
Vascular endothelium