Indomethacin reduce the diuretic action of furosemide by
NSAIDS inhibit specifically PGE2, PGI2 synthesis in renal tubules effecting the hemodynamic changes done by Prostaglandins for water, sodium reabsorption Ref: katzung 12th ed, Autocoids.
Preventing prostaglandin mediated heamodynamic actions
Blockade of furosemide action in loop of henle
Enhancing water reabsorption in distal tubule
Increasing aldosterone secretion
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