In alveolar variant of rhabdomyosarcoma , the resultant fusion protein is believed to function as
In Alveolar rhabdomyosarcoma, there is frequently fusion of the FOXO1 gene to either the PAX3 or the PAX7 gene, rearrangements marked by the presence of (2;13) or(1;13) translocations, respectively. PAX3 is a transcription factor that initiates skeletal muscle differentiation, and it appears that the chimeric PAX3-FOXO1 fusion protein interferes with the gene expression program that drives differentiation.
Activated growth factor receptor
Chimeric transcription factor
Constitutively active kinase
Novel growth factor
JIPMER 2019