Which vitamin deficiency is most commonly seen in a pregnant mother who is on phenytoin therapy for epilepsy?
Phenytoin inhibits the enzyme intestinal conjugase, an impoant enzyme in folic A. Metabolism. Folate is present in food in a polyglutamate form. This is conveed into monoglutamates by intestinal conjugase to be absorbed in the jejunum. Phenytoin acts by inhibiting this enzyme thereby causing folate deficiency and thus megaloblastic anemia.
Vitamin B6
Vitamin B12
Vitamin A
Folic acid
Medical Illness Complicating Pregnancy