Your medical student patient suffers from troublesome allergic rhinitis due to pollen, and you want to prescribe a drug for her that is least likely to cause sedation. Your best choice would be
The usual choice for pollen-induced allergies would be an H1 antagonist. Of the two listed, loratadine would be the best choice in this case because it does not cross the blood-brain barrier and is nonsedating; hydroxyzine is an effective CNS depressant used for preoperative sedation. Cromolyn (not listed) can also be used in allergic rhinitis and is also non-sedating. Betamethasone, a potent anti-inflammatory steroid, is less effective than antihistamines in this situation and would cause more serious side effects. Metoclopramide is a DA receptor antagonist and prokinetic used as an antiemetic and in GERD. Cimetidine is the prototype H2 antagonist used in GI ulcers.
betamethasone
cimetidine
hydroxyzine
loratadine
General Pharmacology