Which of the following is not used in the management of thyroid storm -
Ans. is 'b' i.e., Reserpine Thyroid storm (thyrotoxic crisis) o It is an emergency due to decompensated hypehyroidism. o Treatment includes Non-selective b-blocker o It is the most valuable measure in thyroid storm. In thyroid storm most of the symptoms are because of adrenergic overactivity due to increased tissue sensitivity to catecholamines in hypehyroidism. This increased sensitivity is due to increased number of b-receptors. So, quick relief can be obtained by blocking b-receptors. Prophythiouracil o It is the antithyroid drug of choice for thyroid storm because it reduces hormone synthesis as well as peripheral conversion of T4 to T3. Note: Prophylthiouracil is the DOC amongst antithyroid drugs, but the DOC for thyroid storm is 13-blockers. Coicosteroid (Hydrocoisone) o It inhibits both release of thyroid hormone from the gland and peripheral conversion of T4 to T3. Iodides (Potassium iodide or ipanoic acid) o They are used to inhibit fuher hormone release from the gland. Diltiazem (a calcium channel blocker) may be added if tachycardia is not controlled by propranolol alone. Rehydration, anxiolytics, external cooling and appropriate antibiotics are the other measures.
Potassium iodide
Reserpine
Propranolol
Calcium channel blockers