Diffusion of lipid-insoluble substances across the cell membrane depends on all of the following except
Ans: C. Lipid solubility(Ref: Principle of medicalphysiolog p. 712).Simple diffusion of lipid-soluble substancesThe rate of diffusion through the lipid bilayer of the cell membrane is directly propoional to the solubility of a substance in lipids.Therefore, molecules of substances like orygen, nitrogen, carbon dioxide, alcohol, steroid hormones and weak organic acids and bases, being lipid soluble, diffuse very rapidly through the lipid bilayer of the cell membrane.
Hydrated radius
Electrical charge
Lipid solubility
Shape