Side effect of topiramate is ?
Ans. is 'a' i.e., Weight loss Topiramate Weak carbonic anhydrase inhibitor with broad spectrum anticonvulsant activity. Acts - prolongation of Na+ channel inactivation, GABA potentiation, gultamate receptor antagonism, neuronal hyperpolarisation K+ channels. Used in SPS, CPS, GTCS, myoclonic epilepsy, prophylaxis of migraine. Readily absorbed orally and mainly excreted in urine. T1/2 - 24hrs. Adverse effects impairment of attention, sedation, ataxia, word finding difficulties, poor memory, weight loss, paresthesias, and renal stones.
Weight loss
Visual impairement
Insomnia
Hemolysis