True about Dyshormonogenesis is all Except
Thyroid dyshormonogenesis is usually inherited in an autosomal recessive pattern. Thyroid enlargement may be the only manifestation and dyshormonogenesis should be considered in young patients presenting with euthyroid goitre. The most common abnormalities affect TPO activity and thyroglobulin synthesis. A classic example of dyshormonogenesis due to TPO deficiency is Pendred syndrome, in which goiter is associated with severe sensorineural hearing impairment and abnormality of the bony labyrinth observed on CT examination of the temporal bones.
Autosomal dominant inheritance
Most common abnormality is with thyroid peroxidase activity
Young patients may present with euthyroid goitre
Pendred syndrome is a classic example of dyshormonogenesis due to TPO deficiency
Endocrinology and breast