Bilirubin bound inside hepatocyte to ?
Ans. is 'c' i.e., Ligandin Bilirubin metabolism Bilirubin is the end product of heme degradation. The heme is derived from - i) Senescent erythrocytes by mononuclear phagocytic system in the spleen, liver and bone marrow (major source). ii) Turnover of hemoproteins (e.g. cytochrome p.450). Heme is oxidized to biliverdin by heme oxygenase. Biliverdin is then reduced to bilirubin by biliverdin reductase. Bilirubin is transpoed to liver in bound form with albumin. Bilirubin is transferred to hepatocytes where it is bound to ligandin. There is carrier mediated uptake of bilirubin in the liver. This bilirubin is conjugated with glucuronic acid by UDP glucuronyl transferase (UGT1A1) to from conjugated bilirubin (bilirubin glucronides). Conjugated bilirubin is excreted into bile. Most of the conjugated bilirubin is deconjugated and degraded to urobilinogen. The most of the urobilinogen is excreted in the feces.
Albumin
Ubiquinone
Ligandin
Globulin