Acantholysis means
Answer is option 2, loss of intercellular connections We performed scanning electron microscopy of an inveed blister roof in a case of pemphigus foliaceus. The loss of intercellular adherence could be easily seen with low magnification. The acantholytic keratinocytes displayed an irregular and sometimes polygonal contour. Round cells, typically seen in light microscopy, were also observed. The examination of a blister roof allows ultrastructural documentation of the acantholytic changes.
Diffuse epidermal hyperplasia
Loss of intercellular connections
Intercellular edema of the epidermis.
Abnormal keratinization
Endocrinology