Which of the following is the most likely effect of insulin at the cellular receptor level?
Insulin binding to its receptor stimulates tyrosine kinase activity. Other stimulators of protein kinases include platelet-derived growth factor and epidermal growth factor. Tyrosine phosphorylation results from this interaction. Insulin-resistant states can be caused by pre-receptor resistance (mutated insulin, anti-insulin antibodies) or receptor and post receptor resistance.
stimulating tyrosine kinase
binding to ion channels
binding to intracellular erb A receptors
stimulating guanylate cyclase
Endocrinology