The most clinically significant skin eruption associated with M. pneumoniae infection is:
Erythema multiforme major (Stevens-Johnson syndrome) is the most clinically significant skin eruption associated with M. pneumoniae infection. Ref:Harrisons Principles of Internal Medicine, 18th Edition, Page 1418
Erythema multiforme major
Bullous eruptions
Toxic epidermal necrosis
Pyostomatitis vegetans