The following are features of polycythemia rubra vera, except -
<p>In PV, the major pathogenetic mechanism is a tyrosine kinase JAK2 mutation which removes the autoinhibitory control & activates the kinases.</p><p>Due to erythrocytosis, red cell mass will be increased .Splenomegaly produces abdominal fullness.But in PV, oxygen saturation will be high.</p><p>Reference :Harsh mohan textbook of pathology sixth edition pg no 359.</p>
Increased red cell mass
Low aerial oxygen saturation
Presence of JAK2 mutation
Splenomegaly
Haematology