Mechanism of action of Levetiracetam are all except
(C) Inhibits post synaptic calcium channels# Mechanism of Action:> Inhibits a specific high-voltage activated calcium channel, the N-type> Inhibit the release of calcium from intracellular stores.> Oppose the inhibitory action of zinc and beta-carbolines on GABA- and glycine-gated currents. Inhibits burst firing without affecting normal neuronal excitability.> Hypersynchronization of epileptiform activity is inhibited, and its distinguished Levetiracetam from other AEDs.> Saturable and reversible stereoselective binding site specific for levetiracetam in CNS, SV2A.> Exact mechanism by which levetiracetam acts to treat epilepsy is unknown However, the drug binds to a synaptic vesicle glycoprotein, SV2A, and inhibits presynaptic calcium channels reducing neurotransmitter release and acting as a neuromodulator.> Levetiracetam: Binds to a synaptic vesicle glycoprotein (involved in the regulation of vesicle exocytosis), SV2A, & inhibits presynaptic calcium channels reducing neurotransmitter release & acts as a neuromodulator. Levetiracetam is an anticonvulsant used to treat epilepsy. Levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity.
Used in myoclonic epilepsy
Acts on GABA receptors
Inhibits post synaptic calcium channels
Binds to SV2A and regulates exocytosis of neurotransmitter
Miscellaneous