A 36-yrs-old woman presents with increased trouble swallowing. Physical examination finds hypeension and sclerodactyly. Lab tests find Anti- Scl- 70. Which of the following biopsies is most characteristic of this disorder?
A skin biopsy that reveals dermal fibrosis with an absence of adnexal structures * The combination of trouble swallowing, hypeension, and sclerosis of the skin should raise the possibility of progressive systemic sclerosis (scleroderma), a multisystem disease that involves the cardiovascular, * a peripheral nerve biopsy that reveals rare acid-fast bacteria is diagnostic of leprosy; and a temporal aery biopsy that reveals fragmentation of the internal elastic lamina is characteristic of ternporal aeritis.
A conjunctival biopsy that reveals noncaseating granulomas
A peripheral nerve biopsy that reveals rare acid- fast bacteria
A skin biopsy that reveals dermal fibrosis with an absence of adnexal structures
A subcutaneous fat biopsy that reveals an infiltrate of plasma cells and eosinophils