Aseptic loosening in cemented total hip replacement, occurs as a result of hypersensitivity response to:
B i.e. High density polythene debris Paicles of metal (titanium, nickel, chromium etc), cement (PMMA) and polyethylene all can produce periprosthetic osteolysis (aseptic loosening) ; but because they are most numerous polyethylene paicles appear to be the major culpritQ.
Titanium debris
High density polythene debris
N. N-Dimethyltryptamine (DMT)
Free radicals