Abatacept is used in treatment of which of the following conditions?
Ans. A. Rheumatoid ArthritisAbatacept is a fusion protein composed of Fc region of IgG1 fused to extracellular domain of CTLA-4. It inhibits the co-stimulation of T cells by blocking CD28-CD80/86 interactions. In order for a T cell to be activated, an APC must present two signals to the T cell. One of those signals is the MHC combined with the antigen, and the other signal is the CD80/CD86 molecule. Abatacept binds to CD80 and CD86 molecule and prevents second signal.Belatacept is FDA approved for kidney transplant recipients and is given monthly as an intravenous infusion.
Rheumatoid Arthritis
Asthma
Paroxysmal nocturnal hemoglobinuria
Autoimmune Hemolytic Anemia
Immunomodulator