Alcoholics may develop fatal lactic acidosis due to inhibition of which of the following enzyme?
Pyruvate is decarboxylated by the pyruvate dehydrogenase component of the enzyme complex to a hydroxyethyl derivative of the thiazole ring of enzyme-bound thiamin diphosphate. Arsenite and mercuric ions react with the 'SH groups of lipoic acid and inhibit pyruvate dehydrogenase, as does a dietary deficiency of thiamin allowingpyruvate to accumulate. Many alcoholics are thiamin deficient (both because of a poor diet and also because alcohol inhibits thiamin absorption), and may develop potentially fatal pyruvic and lactic acidosis.Ref: Harper&;s Biochemistry; 30th edition; Chapter 17; Glycolysis & the Oxidation of Pyruvate
Pyruvate dehydrogenase
Dihydrolipoyl transacetylase
Dihydrolipoyl dehydrogenase
Phosphoglycerate kinase
General anatomy