True about epidural opioids are all except:
Ans. (C) Function of the intestine is not affected(Ref: Katzung 11/e p542)Because of their direct action on the superficial neurons of the spinal cord dorsal horn, opioids can also be used as regional analgesics by administration into the epidural or subarachnoid spaces of the spinal column.It was initially assumed that the epidural application of opioids might selectively produce analgesia without impairment of motor, autonomic, or sensory functions other than pain. However, respiratory depression can occur after the drug is injected into the epidural space and may require reversal with naloxone.Effects such as pruritus and nausea and vomiting are common after epidural and subarachnoid administration of opioids and may also be reversed with naloxone if necessary.Currently, the epidural route is favored because systemic adverse effects are less common
Act on dorsal horn substantia gelatinosa
Can cause Itching
Function of the intestine is not affected
Can cause respiratory depression
Opioids