All are true about splenic marginal zone lymphoma, EXCEPT:
Splenic Marginal Zone Lymphoma This tumor originates in the marginal zone of the spleen white pulp (Tumor of small lymphocytes) Splenic hilar nodes are involved The circulating tumor cells are called villous lymphocytes The cells express surface immunoglobulin and CD20 The median age of patients is fifties Patients present with incidental splenomegaly and lymphocytosis in the peripheral blood Autoimmune anemia / thrombocytopenia present The clinical course of disease is indolent Long remissions after splenectomy Ref: Harrison, E-18, e-21.
Autoimmune anemia / thrombocytopenia present
This tumor of small lymphocytes originates in the marginal zone of the spleen white pulp
Splenic hilar nodes are involved
The clinical course is virulent