All of the following are true about Hepcidin except
Hepcidin, a 25-amino acid peptide secreted by hepatic Kupffer's cells downregulates duodenal iron absorption by regulating DMT1 activity as well as other proteins in the iron-responsive pathways (e.g., FP1). Hepcidin is a negative regulator of iron absorption because mice that fail to express hepcidin have elevated body iron stores, whereas mice with enhanced hepcidin expression have profound iron deficiency. .
It is a 25- amino acid peptide secreted by Kupffer cells
Decreases duodenal absorption of iron
It regulates activity of transpoers DMT - 1 and ferropoin - 1
Mice with enhanced hepcidin expression have elevate body iron stores
General physiology