Patient with pruritic lesion over Left shoulder showing cigarette paper atrophy and poikiloderma with generalized lymphadenopathy. Histopathologv exmanination of lesion shows CD4 positive sezary leutzner cells. What is the dermo- epidermal manifestation of this disease?
Ans. is 'a' i.e., Pautrier's micro abscess o Patient with pruritic lesion over Left shoulder showing cigarette paper atrophy and poikiloderma with generalized lymphadenopathy. Histopathologv exmanination of lesion shows CD4 positive sezary leutzner cells - points to the diagnosis of Mycosis fungoides.HistplogicaLfeatures of mycpsis fungoideso Histological hallmark is the presence of sezary-Lutzner cells (CD4 positive).o These sezary-Lutzner cells form band like aggregates within superficial dermis and invade epidermis as single cells and small clusters, referred to as pautrier microabscess,o There is pronounced infiltration of sezary-lutzner cells into epidermis which is referred to as epidermotropism.o In more advanced nodular stage these malignant T cells (sezary cells) lose their epidermotropic tendency and grow deeply into the dermis, and eventually seed lymphatics and peripheral circulation.
Pautrier's micro abscess
Pin point ulcers
Discharging sinus
Miliaria
Autoimmune Skin Disorders