All are true about Clozapine except
side effects are sedation, unstable BP, tachycardia, urinary incontinence, weight gain and precipitation of diabetes. Few cases of myocarditis have been repoed which sta like flu but may progress to death. Clozapine is used as a reserve drug in resistant schizophrenia. Its mechhanism as follows Ref: KD TRIPATHI 8TH ED.
More potently blocks D2 as compared to D1 receptors
Blood level below 350 ng/ml should be maintained to avoid agranulocytosis
Should not be used along with Carbamazepine
Should be discontinued if the WBC count is below 3,000/ .' mm cells
Central Nervous system