Mechanism of action of Fluoroquinolones is
(Inhibit DNA gyrase) (628, 647-KDT) (688-KDT 6th)Fluoroquinolones (FQs)* First generation FQs - Norfloxacin, Ciprofloxacin, Ofloxacin, Pefloxacin* Second generation FQs - Lomefloxacin, Sparfloxacin, Levofloxacin, Gatifloxacin, Moxifloxacin.* FQs inhibits the enzyme bacterial DNA gyrase, which nicks double stranded DNA, introduces negative super coils and then reseals the nicked ends.* FQ action is similar enzyme topo isomerase IV, which nicks and separates daughter DNA strands after DNAreplication.
Inhibit cell wall synthesis
Inhibit protein synthesis
Inhibit DNA gyrase
Interfere with DNA synthesis
Anti Microbial