Mechanism of action in pathogenesis of Pseudomembranous colitis by CI difficle ?
Ans. is 'c' i.e., Due to exotoxin Pathogenesis of pseudomembranous colitis is due to production of two large toxins by C. difficile : i) Toxin A (an enterotoxin) Is a potent neutrophil chemoattractant Causes disruption of cell cytoskeleton by glycosylation of GTP - binding proteins that regulate the actin cell cytoskeleton. ii) Toxin B (a cytotoxin) Causes disruption of cell cytoskeleton by similar mechanism.
Due to invasiveness
Due to endotoxin
Due to exotoxin
Due to NM blockade