Best method of estimation of amount of proteinuria in a child with nephrotic syndrome is -
Ans. is 'b' i.e., 24 hr urine for protein and creatinine Methods Available to Test for ProteinuriaMethodIndicationsNormal RangeCommentsDipstick testingRoutine screening for proteinuria performed in the officeNegative of trace in a concentrated urine specimen (specific gravity: > 1.020)False-positive test can occur if urine is very alkaline (pH > 8.0) or very concentrated (specific gravity: > 1.025)24hr urine for protein and creatinine* excretionQuantitation of proteinuria (as well as creatinine clearances)<100 mg/m2/24hr or < 150 mg/24 hr in a documented 24 hr collectionMore accurate than spot urine analysis: inconvenient for patient; limited use in pediatric practice.Spot urine for protein/ creatinine ratio-preferably on first morning urine specimen.Semiquantitative assessment of proteinuria.< 0.2 mg protein/mg creatinine in children > 2yr old.< 0.5 mg protein/mg creatinine in those 6-24 mo old.Simplest method to quantitate proteinuria: less accurate than measuring 24hr proteinuria.MicroalbuminuriaAssess risk of progressive glomerulopathy in patients with diabetes mellitus.< 30mg urine albumin per gram of creatinine on first morning urine.Therapy should be intensified in diabetics with microablbuminuria.
Dipstick testing
24 hr urine for protein and creatinine
Spot urine sample for protein/ creatinine ratio
Microalbuminuria
Kidney