Deficiency of purine nucleoside phosphorylase causes -
Ans. is 'b' i.e., Cellular immunodeficiency o Purine nucleoside phosphorvlase is involved in purine nucleoside catabolism.o Purine nucleoside phosphorylase (PNP) deficiency is an autosomal recessive disorder,o It is characterized by decreased cell mediated immunity and recurrent infection,o There is a severe T-cell deficiency with normal B-cel! function.o They usually present with hypoplastic anemia with recurrent pneumonia, diarrhea and candidiasis.Also knowo Adenosine deaminase deficiency causes severe combined immunodeficiency.
Complement deficiency
Cellular immunodeficiency
Humoral immunodeficiency
Combined immunodeficiency
Metabolism of Purines and Pyrimidines