In which of the following ways does aldosterone react with renal tubular cells?
Aldosterone increases transpo of ENaCs (epithelial sodium channels) from the cytoplasm to the cell membrane. This is a rapid effect of aldosterone. Adosterone diffuses into the tubular epithelial cells. In the cytoplasm of these cells, aldosterone combines with a mineralocoicoid receptor (MR) protein. The aldosterone-receptor complex diffuses into the nucleus and induces transcription of DNA to form mRNA. The mRNA diffuses back into the cytoplasm and protein formation occurs in the ribosomes. This occurs slowly. The impoant products formed are: Na+K+ATPase, and membrane transpo proteins like epithelial sodium channel proteins. Ref: Guyton And Hall 13th edition Pgno: 970,971
Increases transpo of ENaCs from the cytoplasm to the cell membrane
Binds to steroid receptor inside the nucleus of renal tubular cells
Binds to ENaC's on the cell membrane and increase Na+ transpo
Binds to G-protein coupled receptors on the cell surface
Endocrinology