The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDs because they:
Ans. (D) Decrease the synthesis of vascular prostacyclins(Ref: KDT 8th/e p215)*PGE2 and PGI2 cause renal vasodilation, natriuresis and increased water clearance due to inhibition of the action of ADH.*Loop diuretics act partly by increasing the stimulation of COX; therefore NSAIDs attenuate the diuretic action of these drugs.
Cause sodium excretion
Increase the clearance of antihypertensive drugs
Decrease the absorption of antihypertensive drugs
Decrease the synthesis of vascular prostacyclin
C.V.S