Which of the following is not synthesised from mevalonate?
Cholesterol synthetic pathway is also involved in the synthesis of many other impoant compounds such as: Farnesyl pyrophosphate and geranyl pyrophosphate - involved in prenylation of proteins. Dolichol - involved in N-glycosylation of proteins in endoplasmic reticulum. Ubiquinone (Q10) - is the electron carrier in the mitochondrial respiratory chain. Inhibition of ubiquinone synthesis is one of the reasons for statin-induced myopathy. Ubiquitin protein is not synthesized by any of the cholesterol synthesis pathway intermediate.
Farnesyl pyrophosphate
Geranyl pyrophosphate
Dolichol
Ubiquitin
Cholesterol synthesis and bile acids