All are causes of spastic paraplegia except:
Ans: d (Fluorosis)Ref: Harrison, 17 ed. pg. 2595 Adam & Victor NeurologySACD ( B defeciency)* Subacute paraesthesia in hand & feet, spatic paraparesis, loss of posterior column sensations, optic atrophy, irritability/mental changes.Causes loss of ankle jerk with extensor plantar.Motor neuron disease* Usually presents as insidious onset assymetric weakness of distally in one of the limbs.* Progressive wasting and atrophy of the muscles with fasciculations* Exaggerated DTR with spastic weakness of the limbs in predominant corticospinal involvement* Spares cognitive functions, bowel & bladder, sensory system and ocular motility till late stages.ADEM: Clinical featuresEncephalitic form - fever, headache, confusion, convulsions, coma, decerebrate rigidity.Myelitic form -Partial or complete paraplegia/quadriplegiawith varying degree of bowel& bladder involvement.Flurosis: Even though there are case reports about fluorosis presenting as spastic paraparesis due to involvement of the spine it is very rare and hence the most possible answer here.
Subacute combined degeneration
Motor neuron disease
Acute demyelinating encephalopathy
Fluorosis
C.N.S.