Which antibody is incriminated in causing Henoch Schonlein Purpura?
Ans. (a) IgARef: Harrison 18th edition, Chapter 326* The Presumptive pathogenic mechanism for Henoch- Schonlein purpura is immune-complex deposition.* IgA is the antibody class most often seen in the immune complexes and has been demonstrated in the renal biopsies of these patients.* A number of inciting antigens have been suggested including upper respiratory tract infections, various drugs, foods, insect bites, and immunizations.
IgA
IgG
IgM
IgD
Vasculitis