All of the following genes may be involved in development of carcinoma of colon Except
.Detection of mutations in congenital conditions like von - Hippel - Lindau disease (vHL gene); haemochromatosis (HFE gene); colorectal carcinoma(APC gene).Familial gastric cancer in associated with mutation of e-cadherin gene (90% risk). It causes hereditary diffuse gastric cancer. Relatives of such family show mutation of this gene. Whether prophylactic total gastrectomy is needed or not in these high risk individuals is a debate. ref:SRB&;s manual of surgery ,ed 3,pg no 777
APC
Beta-Catenin
K-ras
Mismatch Repair Genes
G.I.T