All are true about macula densa except
This mechanism involves a feedback loop in which the concentration of NaCl in the tubular fluid is sensed by the macula densa of the juxtaglomerular apparatus and conveed into a signal or signals that affect afferent aeriolar resistance and thus the GFR. When the GFR increases and causes in the tubular fluid at the macula densa to rise, more NaCl enters the macula densa cells. This leads to an increase in the formation and release of ATP and adenosine, a metabolite of ATP, by macula densa cells, which causes vasoconstriction of the afferent aeriole. Vasoconstriction of the afferent aeriole returns the GFR to normal levels.
Sensor for glomerulotubular balance
The Na+ and Cl- enter the macula densa cells the Na-K-2Cl cotranspoer in their apical membranes
Increased formation and release of adenosine in macula densa cells
Causes vasoconstriction of afferent aeriole
Renal physiology