First order kinetics is characterized by:
First order (exponential) kinetics; The rate of elimination is directly propoional to the drug concentration, Clearance remains constant, or a constant fraction of the drug present in the body is eliminated in unit time. Ref:KD Tripathi pharmacology 7th edition (page.no: 30)
Dose independent elimination
Decreasing clearance as plasma concentration increases
Increasing rate of elimination as plasma concentration increases
No relationship between rate of elimination and plasma concentration
General pharmacology