Viral enterotoxin is detected as a possible mechanism of pathogenesis in :
Mechanism of Rotavirus diarrhea :
a. Rotavirus destroy mature enterocytes of proximal small intestine.

Loss of absorptive villi and proliferation of secretory crypt cells

– Secretory diarrhea

Brush border enzymes are reduced so unmetabolized disaccharides accumulates resulting.

– Osmotic diarrhea
b. NSP4 = enterotoxin which alteres epithelial cell function and permeability causing secretory diarrhea.
c. Virus evoke fluid secretion by the activation of enteric nervous system in intestinal wall.
Adeno virus
Rota virus
Calcivirus
Astrovirus