What of the following is true about plasma tl/2-
Ans. is 'd' i.e., T 1/2 remains constant for the drugs eliminated by first order kinetics Ivermectin* Ivermectin is an extremely potent semisynthetic derivative of nematodal principal obtained from Streptomyces avermitilis.* It is the DOC for single dose treatment of onchocerciasis and strongyloidosis.* It is the only oral drug effective against scabies and pediculosis.* It acts by glutamate gated Cl- channel which causes tonic paralysis in nematodes.* Following table depicts the drugs used for the management of round worm infections.Infection OrganismDrug of ChoiceAlternative DrugsRoundworms (nematodes) Ascaris lumbricoides (roundworm)Albendazole's or pyrantel pamoate or membendazolePiperazineTrichuris trichiura (whipworm)Mebendazole or albendazoleOxantel/pyrantel pamoateNecator americanus (hookworm); Ancylostoma duodenale (hookworm)Pyrantel pamoate or mebendazole or albendazole Strongyloides stercoralis (threadworm)IvermectinThiabendazole, albendazoleEnterobius vermicularis (pinworm)Mebendazole or pyrantel pamoateAlbendazole fTrichinella spiralis (trichinosis)Mebendazole, add corticosteroids for severe infectionAlbendazole; add corticosteroids for severe infectionTrichostrongylus speciesPyrantel pamoate or mebendazoleAlbendazoleCutaneous larva migrans (creeping eruption)Albendazole or ivermectinThiabendazole (topical)Visceral larva migransAlbendazoleMebendazoleAngiostrongylus contonensisThiabendazoleAlbendazole or mebendazoleWuchereria bancrofti (filariasis); Brugia malayi (filariasis); tropical eosinophilia; Loa loa (Ioiasis)DeithylcarbamazineIvermectinOnchocerca volvulus (onchocerciasis)Ivermectin Dracunculus medinensis (guinea worm)MetronidazoleThiabendazole or mebendazoleCapillaria phillippinensis (intestinal capillariasis)AlbendazoleMebendazole or thiabendazole
Is same as bioavailability
It is directly proportional to clearance
It is inversely proportional to volume of distribution
Tl/2 remains constant for the drugs eliminated by first order kinetics
General Pharmacology