All statements regarding ketamine are true except –
Cerebrovascular responsiveness to CO2 is preserved, and reducing the arterial CO2 tension by hyperventilation attenuates the ketamine induced rise in IOT.
Ketamine has direct myocardial depressant and vasodilator effect. It also has indirect sympathomimetic action which predominates over direct depressant and vasodilator action → usual response is raised BP, CO & HR.
Ketamine can cause arrhythmias as it sensitizes the heart to adrenaline.
It can produce emergence psychiatric reaction.
May be arrythmogenic
Raised ICT do not respond to CO2 level
Vasodilator and negative ionotropic effect
Psychomimetic emergence