H. capsulatum, is found in soil heavily contaminated with bird droppings. Which of the following statements best describes the presence of the organism in tissue biopsies?
H. capsulatum is a dimorphic fungus that forms two types of spores: tuberculate macroconidia and microconidia. Inhalation of the microconidia transmits infection. Inhaled spores (microconidia) are engulfed by macrophages and develop into yeast forms. Most infections remain asymptomatic; small granulomatous foci heal by calcification. However, pneumonia can Occur. The heterophile anti body test is useful for early diagnosis of infectious mononucleosis.
Arthrospores
Oval budding yeast inside macrophages
Single-cell yeast with pseudohyphae
Spherules containing endoscopores