Bleeding disorders with it APTT andt PT:
Answer is option 2, severe liver disease Liver disease is associated with impairment of the haemostatic function due to the abnormal and decreased synthesis of the clotting factors. It is thus only logical to have considered assessment of the clotting profile (to include prothrombin time (PT) and activated paial thromboplastin time (aPTT)) to be an integral pa of the comprehensive assessment of a patient who presents with liver impairment. Laboratory abnormalities of coagulation are considered to be a predictive risk factor for bleeding, but patients with liver disease do not have bleeding pattern as those who have coagulation factor deficiencies. Ref Robbins 9/e pg 450
Factor 13 deficiency
Severe liver disease
Immune thrombocytopenic purpura
Leiden (Factor V) deficiency
Haematology