In sickle cell anemia change in the amino acid is
(A) valine instead of glutamic acid in the 6th position of beta chain# Molecular basis of Sickle cell hemoglobin:> In case of sickle cell disease, the hemoglobin (HbS) has two normal a chains and two abnormal b chains.> This is due to a difference in a single amino acid. In HbS, glutamate at 6th position b-chain of is replaced by valine.> This occurs due to a change (missense mutation) in the single nucleotide (thymine a adenine) of the b globin gene. This error causes the formation of altered codon (GUG in place of GAG) which leads to the incorporation of valine at the 6th position.
Valine instead of glutamic acid in the 6th position of b chain
Glutamic acid instead of valine in the 6th position of b chain
Valine instead of glutamic acid in the 6th position of a chain
Glutamic acid instead of valine in the 6th position of a chain
Misc.