Leflunomide used against Rheumatoid arthritis acts by inhibiting:
Leflunomide inhibits Dihydroorotate Dehydrogenase and inhibits synthesis of pyrimidine and arrests growth of B-cells.
Ionisne monophosphate dehydrogenase
Dihydroorotate dehydrogenase
Aldehyde  dehydrogenase
TNF-α receptor