A 37-year-old man is admitted to the hospital with a productive cough, fever, and night sweats. An X-ray film of the chest shows an ill-defined area of consolidation at the periphery of the right middle lobe and mediastinal lymphadenopathy. Sputum culture grows acid-fast bacilli. Lymph node biopsy in this patient would most likely show which of the following pathologic findings?
Tuberculosis is a chronic, communicable disease in which the lungs are the prime target. The disease is caused principally by Mycobacterium tuberculosis hominis (Koch bacillus), but infection with other species occurs, notably M. tuberculosis bovis (bovine tuberculosis). Primary tuberculosis consists of lesions in the lower lobes and subpleural space, referred to as the Ghon focus. The infection then drains to hilar lymph nodes. The combination of Ghon focus and hilar lymphadenopathy is known as "Ghon complex." The typical lesion of tuberculosis is a caseous granuloma, with a soft core surrounded by epithelioid macrophages, Langhans giant cells, lymphocytes, and peripheral fibrosis. Noncaseating granulomas (choice D) are a feature of sarcoidosis, among other causes.Diagnosis: Primary tuberculosis
Caseating granulomas
Follicular hyperplasia
Nodular amyloidosis
Noncaseating granulomas
Infectious Disease