Nitrates act by -
Ans. is 'b' i.e., Activate/Guanyl/cyclase and increase cGMP Mechanism of action of nitrates:* Organic nitrates are rapidly denitrated enzymatically in the smooth muscle cell to release nitric oxide (NO) which activates cytosolic guanyl cyclase - | cGMP - Vasodilatation.* Veins express greater amount of the enzyme that generates NO from organic nitrates than arteries - Account for the predominant venodilatory effect.
Activate guanyl cyclase and decrease cGMP
Activate guanyl cyclase and increase cGMP
Activate adenyl cyclase and decrease cAMP
Activate adenyl cyclase and decrease cAMP
C.V.S