Sickle cell trait can cause following except
Ans. B. (Leg ulcers) (Ref. H-17th/637; Table 99-2; 18th Table 104-2)ConditionClinical AbnormalitiesHemoglobin Level g/L (g/dL)MCV, fLHemoglobin ElectrophoresisSickle cell traitNone; rare painless hematuriaNormalNormalHb S/A:40/60Sickle cell anemiaVasoocclusive crises with infarction of spleen, brain, marrow, kidney, lung; aseptic necrosis of bone; gallstones; priapism; ankle ulcers70-100 (7-10)80-100Hb S/A: 100/3Hb F:2-25%S/Bdeg thalassemiaVasoocclusive crises; aseptic necrosis of bone70-100 (7-10)60-80Hb S/A:100A)Hb F:l-10%S/B+ thalassemiaRare crises and aseptic necrosis100-140 (10-14)70-80Hb S/A:60/40Hemoglobin SCRare crises and aseptic necrosis; painless hematuria100-140(10-14)80-100Hb S/A:50/3Hb C:50%
Anaemia
Leg ulcers
Normal osmotic fragility
None
Blood