Treatment of leukoplakia -
Treatment of oral leukoplakia 

Usually, all that is needed for the treatment of oral leukoplakia is just to remove the source of the irritation. If leukoplakia is caused by a rough edge of a tooth, filling or crown or by a denture that does not fit properly, the surface should be smoothed and the dental appliances repaired.
For most people, changing life habits by stopping smoking or alcohol consumption clears the condition in a few weeks or months.
If removing the irritating factor is not effective in clearing the patches, leukoplakia treatment may include surgical removal (excision) or ablation with laser or cryotherapy.
A biopsy should be conducted to rule out malignancy.
Local excision
Excision and radiotherapy
Topical chemotherapy
Repositioning of ill fitting dentures