Metoclopromide -
Ans. is 'b' i.e., Increases lower esophageal sphinctor pressure Effects of metoclopramide on GIT Metoclopramide has 5-HT4 agonistic and D2 antagonistic activity in GIT. o These two actions result in enhanced cholinergic smooth muscle stimulation. o Metoclopramide has prominent effect on upper GIT i) Increases gastric peristalsis ii) Relaxes pylorus and first pa of duodenum iii) Tone of lower esophageal sphinctor is increased o Metoclopramide has no or minimal effect on lower GIT --> increases intestinal motility to some extent, but has no action on colonic motility.
Inhibits cholinergic smooth muscle stimulation in the Gastrointestinal tract
Increases lower esophagial sphinctor pressure
Stimulates D2 receptors
Enhances colonic motility