All of the following are limitations of typical tricyclic antidepressants EXCEPT:
(Ref: KDT 6/e p443, 444) TCAs have very good oral absorption These agents have narrow therapeutic index and thus low safety margin. Sedation and anticholinergic adverse effects are seen frequently with the use of TCAs. Antidepressant actions of both TCAs as well as SSRIs take several weeks to manifest.
Narrow safety margin
Low oral bioavailability
Frequent side effects
Long latent period for response
Other topics and Adverse effects