True about polycythemia rubra vera is all Except:
Answer is D (Increased Infection) Polveheinia vera is not associated with an increased predisposition to infections. ESR levels are characteristically normal or reduced 'ESR' is characteristically low or normal. If this is abnormal another diagnosis or a complication shiuld be considered' - Diagnostic Hematology Polycythemia vera is associated with an increased incidence of both thrombosis and bleeding Both aerial and venous thrombosis may be seen in Polycythemia vera. Paradoxically patients may show a tendency of bleeding and bruising, mainly due to platelet of dysfunction. Clinical Features Clinical Features Clinical Features These result from Erythrocytosis (polycythemia) and increased blood viscocity These result from 1' Basophils and increased secretion of Histamine These result from increased and Platelets functional abnormalities (Increase risk of both thrombosis and / or platelet bleeding) * Patients are plethoric or * Intense pruritis Platelets Abnormal platelet cyanotic * Peptic ulceration (Along with hyperviscocity) function * Neurological symptoms Q . - veigo. tinnitus - heaacdhe Thrombosis Bleeding * Deep viens thrombosis * Upper GI - dizziness - visual disturbance * Hepatic vein thrombosis bleeding from Dimness or vision/ from * Budd chiari syndrome bleeding peptic blockade of retinal vessels * Poal and mesenteric ulcer * Systolic Hypeension Q venous thrombosis (most common * Splenomegaly * Myocardial infarction site of bleeding) * Stroke * Digital ischemia Laboratory features Laboratory features Laboratory features * Increased red cell count * Mild to moderate leucocytosis * Increased platelet count * Increased hemoglobin it TLC) * Platelet functional abnormalities( In upto 80% patients) * Increased hematocrit * Neutrophils are normal * Abnormal platelet aggregation studies. * MCV, MCH and MCHC are normal or low * I Leukocyte alkaline phosphatase (LAP)Q * i blood viscosity * I Transcobalamine I and III * I ESR (ESR is reduced)Q * I Vitamin B12 binding capacity Neutrophils are essentially normal and hence there is no increased predisposition Jar injections
Bleeding
Thrombosis
led ESR
Infection