Lovastatin causes
Ans. is 'a' and 'c' i.e., Increased LDL receptor and Decreased LDL cholesterol Statins -Mechanism of action -Decrease the synthesis of cholesterol by inhibition of rate limiting enzyme HMG CoA. reductase.Effect on lipids Decrease in lipids Decrease Triglycerides Increase HDLStatins decrease synthesis of cholesterol by liver (inhibition of HMG CoA reductase). This leads to compensatory increase in LDL receptor expression on liver cells.Increased LDL receptor causes increase uptake and catabolism of IDL and LDL. This reduces LDL and IDL concentration.Other important points about statinsStatins are administered at bed time to obtain maximum effectiveness.Simvastatin is more potent than lovastatinSimvastatin has extensive first pass metabolismPravastatin causes decrease in fibrinogen level.Statins cause myopathy and lens opacity
Increased LDL receptor
Decreased HDL cholesterol
Decreased LDL cholesterol
Increased SGOT/SGPT ratio
Hypolipidemic