Which of the following drug inhibits the enzyme 11-beta- hydroxylase responsible for coisol synthesis:-
Etomidate Inhibits the activity of II-B- hydroxylase an enzyme necessary for the synthesis of coisol, aldosterone ,17- hydroxyl-progesterone and coicosterone. Associated with adrenocoical suppressionwhich canlast for 72 hours. Inhibits the enzyme 11b-hydroxylase, - decreased biosynthesis of coisol and mineralocoicoid and increases the formation 11-deoxycoicosterone. More potent inhibitor of steroid synthesis than as a sedative-hypnotic as the concentration which produces adrenocoical suppression(10 ng/mL)is much lower than that needed for hypnosis (>200 ng/mL).
Thiopentone
Propofol
Etomidate
Ketamine
Intravenous Anesthetic Agents