The most impoant mechanism by which gram negative bacilli acquire chloramphenicol resistance is:
Resistance to chloramphenicol is usually by a plasmid encoded enzyme acetyltransferase which inactivates the drug. it can also be due to decreased permeability of the drug into the cell and also due to ribosomal mutation. Antimicrobial resistance through inactivating enzymes develops against: A: Aminoglycosides B: Beta lactams C: Chloramphenicol
Decreased permeability into the bacterial cell
Acquisition of a plasmid encoded for chloramphenicol acetyl transferase
Lowered affinity of the bacterial ribosome for chloramphenicol
Switching over from ribosomal to mitochondrial protein synthesis
Protein Synthesis Inhibitors