All of the following statements about Penicillin Resistance is true, EXCEPT:
Alteration in target Penicillin Binding Proteins (PBPs) is an impoant resistance mechanism in gram positive bacteria and not gram negative. It is very unusual to encounter Gram Negative bacteria that have acquired Resistance to b -Lactam Antibiotics due to an alteration in target (Penicillin Binding Proteins). Ref: Antimicrobial Resistance : A Crisis in Health Care By Jungkind, Page 17; Jawetz, Melnick and Adelberg's Medical microbiology, 23rd Edition, Page 175.
b- Lactamase production is the most common mechanism of resistance
Alteration in target PBPs is an impoant resistance mechanism in Gram negative bacteria
Alteration in permeability / penetration of antibiotic causes resistance only in Gram negative bacteria
b-Lactamase production causes resistance in both Gram positive and Gram negative bacteria