A 20 yr old female presents with primary amenorrhea. She has low LH, FSH, estrodial levels. She has anosmia and no secondary sex characteristics on examination. What is the likely diagnosis?
Kallmann syndrome Kallmann syndrome is caused from defective gonadotropin releasing hormone (GnRH) synthesis. Clinical features- Anaemia & hyposmia due to olfactory bulb agenesis & hypophasia. Color blindness, optic atrophy, nerve deafness. Cleft palate, cryptoorchidism & mirror movements (neurological defects) In males- delayed pubey, micropenis. In females- primary amenorrhea, failure of secondary sexual development. Low LH & FSH levels & sex steroids.
Kaagener syndrome
Kallman syndrome
Alpo's syndrome
None