Gamma Gandy bodies are seen in all except-
Ans-C Hemosiderosis Ref- Image Source- Splenic siderotic nodules, also known as Gamma-Gandy bodies, of the spleen, are most commonly encountered in portal hypertension. The pathophysiological process is the result of microhemorrhage resulting in haemosiderin and calcium deposition followed by fibroblastic reaction. Pathology Grossly, Gamna-Gandy bodies are characterized by many well-circumscribed nodules measuring several millimeters, with a dark hemorrhagic center surrounded by a pale inner hyperaemic rim and a dark outer rim. This gives an appearance resembling "tobacco flecks". Histologically, there is deposition of haemosiderin and calcium within the connective tissue stroma and vessels with a fibroblastic reaction, leading to microarchitectural distortion. Associations Recognised associations include 4 portal hypertension per se, or caused by portal or splenic vein thrombosis paroxysmal nocturnal hemoglobinuria sickle cell anemia hemolytic anemias leukemia lymphoma patients receiving blood transfusions acquired hemochromatosis splenic haemangiomatosis - diffuse splenic haemangiomatosis splenic neoplasms benign littoral cell angioma of the spleen haemangioendothelioma of the spleen malignant - angiosarcoma of the spleen cardiac myxomas hepatosplenic schistosomiasis Radiographic features Ultrasound Multiple tiny echogenic foci without acoustic shadowing. MRI Siderotic foci (often less than 1 cm 4) are punctate foci within the spleen. The high magnetic susceptibility effect of haemosiderin typically renders the siderotic foci markedly hypointense on certain sequences. Hence, signal characteristics of the nodules include: T2: very low-signal gradient echo (GE) / SWI: low-signal (considered the most sensitive sequence for detection of siderotic nodules 1)
Cirrhosis with portal hypertension
Chronic myeloid leukemia
Hemosiderosis
Sickle Cell anemia