Pancuronium differs from tubocurarine in that:
* Pancuronium possesses vagolytic activity and can cause hypeension and tachycardia on rapid i.v. injection. * Pancuronium is a competitive NM blocker (Non-depolarizing NM blocker). Its actions can be reversed by anticholinesterases like neostigmine. * Unlike d-TC, histamine release is not seen with pancuronium.
It is a depolarizing blocker
Its action is not reversed by neostigmine
It can cause rise in BP on rapid I.V. injection
It causes marked histamine release
Anaesthesia