What is true regarding sulfasalazine?
Around 90% of a dose of sulfasalazine reaches the colon, where most of it is metabolized by bacteria into sulfapyridine and mesalazine (also known as 5-aminosalicylic acid or 5-ASA).5 ASA is the active moiety produced in the colon in U.Colitis.In rheumatoid ahritis the active moiety is sulphapyridine.Ref: Katzung 13th ed. Pg: 1072
Active moiety is 5 amino salicylic acid in ulcerative colitis
Inactive moiety is 5 amino salicylic acid in ulcerative colitis
Inactive moiety in rheumatoid ahritis is Sulfapyridine
It gets activated in the stomach
Immunomodulators