All of the following statements about `Aprepitant' are true, except:
Ans is 'a' i.e. Agonist at Neurokinin receptor (NK1) Aprepitant is an antiemetic substance that belongs to a class of drugs called substance P antagonists. o The compound mediates its effect by blocking the neurokinim 1 (NK1) receptor. o Aprepitant crosses the blood brain barrier. o Aprepitant is used for chemotherapy induced nausea & vomiting (CINY), and post- operative nausea & vomiting (PONV). o After absorption aprepitant is bound extensively to plasma proteins (>95%); it is metabolized avidly, primarily by hepatic CYP 3A4 and is excreted in the stools.
Agonist at Neurokinin receptor (NK1)
Crosses the blood brain barrier
Metabolized by CyP3A4 pathway
Ameliorates nausea and vomiting of chemotherapy