A 40-year-old male presented with symptoms of anemia along with weight loss, night sweats, and low-grade fever.On examination, splenomegaly, petechiae, ecchymosis, lymphadenopathy was noted along with some features of poal hypeension.Lab findings revealed anemia, leukocytosis and thrombocytosis. Bone marrow aspiration reveals a dry tap. Bone marrow biopsy was taken and subjected to reticulin staining.. All of the following genes can be mutated in the above condition except: -
This is a case of primary myelofibrosis. Primary myelofibrosis. Peripheral smear shows teardrop red blood cells (RBCs) and a leukoerythroblastic picture with nucleated RBC precursors and immature myeloid cells. Bone marrow biopsy from a patient with primary myelofibrosis shows extensive fibrosis which is confirmed by reticulin staining. Mutations in the JAK2, MPL, CALR, and TET2 genes are associated with most cases of primary myelofibrosis.
JAK2
CALR
MPL
ACTN3
Integrated QBank