Which of the following drug is used to counter central anticholinergic effect?
Physostigmine is effective in the treatment of central anticholinergic toxicity caused by overdoses of atropine or scopolamine. In addition, it reverses some of the central nervous system depression and delirium associated with use of benzodiazepines and volatile anesthetics. Physostigmine (0.04 mg/kg) has been shown to be effective in preventing postoperative shivering. It repoedly paially antagonizes morphine-induced respiratory depression, presumably because morphine reduces acetylcholine release in the brain. Ref: Butterwoh IV J.F., Butterwoh IV J.F., Mackey D.C., Wasnick J.D., Mackey D.C., Wasnick J.D. (2013). Chapter 12. Cholinesterase Inhibitors & Other Pharmacologic Antagonists to Neuromuscular Blocking Agents. In J.F. Butterwoh IV, J.F. Butterwoh IV, D.C. Mackey, J.D. Wasnick, D.C. Mackey, J.D. Wasnick (Eds), Morgan & Mikhail's Clinical Anesthesiology, 5e.
Physostigmine
Atropine
Neostigmine
Hyoscine