Which of the following is the etiology of Werner syndrome?
Werner syndrome: It is a hereditary condition with premature aging due to mutation in the WRN gene There is Loss of function DNA helicase. This results in the shoening of the telomeres with damaged DNA. There is increased risk of cancer in the individuals with Werner syndrome.
Increased length of telomere
Sho telomere with damaged DNA and loss of helicase
Increased advanced glycation end products
Decreased lipid peroxidation
NEET Jan 2020