Which among the following is true about Super antigens?
A group of antigens have been termed superantigens because they stimulate a much larger number of T cells than would be predicted based on the specificity of combining site diversity. This causes a massive cytokine release. The action of superantigens is based on their ability to bind directly to MHC proteins and to paicular V regions of the TCR without involving the antigen combining site. Individual superantigens recognize exposed poions defined by framework residues that are common to the structure of one or more V regions. Any T cells bearing those V sites may be directly stimulated. Ref: Ray C.G., Ryan K.J. (2010). Chapter 2. Immune Response to Infection. In C.G. Ray, K.J. Ryan (Eds), Sherris Medical Microbiology, 5e.
They bind to the cleft of the MHC
Needs to processed before presentation
They are presented by APC' S to T cells
Directly attached to lateral aspect of TCR B chain