A 27 year old female having a family history of autoimmune disease presents with the complaints of a skin rash and recurrent joint pains 3 months after delivering a baby. She is most likely to have which of the following disorders?
Acquired factor VIII deficiency Muscle and soft tissue bleeds are common. Bleeding into a joint results in severe pain and swelling, as well as loss of function, but is rarely associated with discoloration from bruising around the joint. Life-threatening sites of bleeding include bleeding into the oropharynx, where bleeding can obstruct the airway, into the central nervous system, and into the retroperitoneum. Mixing studies -used to evaluate a prolonged aPTT or PT. -to distinguish between a factor deficiency and an inhibitor. In this assay, normal plasma and patient plasma are mixed in a 1:1 ratio, and the aPTT or PT is determined immediately and after incubation at 37degC for varying times, typically 30, 60, and/or 120 min. -With isolated factor deficiencies, the aPTT will correct with mixing and stay corrected with incubation. With aPTT prolongation due to a lupus anticoagulant, the mixing and incubation will show no correction. -In acquired neutralizing factor antibodies, the initial assay may or may not correct immediately after mixing but will prolong with incubation at 37degC.
Megakaryocytic thrombocytopenia
Amegakaryocytic thrombocytopenia
Functional platelet defect
Acquired Factor VIII inhibitors
Clotting factor