The recently approved antiepileptic drug lacosamide acts by:
(Ref: Katzung, 14th ed. pg. 417)* CRMP is Collapsing Response Mediator Protein, which causes neuronal excitotoxicity by releasing BDNF (Brain Derived Neurotropic Factor).* The drug Lacosamide acts by inhibiting CRMP protein, thereby causing protective action against neuronal excitotoxicity.
Inhibiting synaptic vesicular protein
Inhibing CRMP protine
Inhibing GABA metabolism
Inhibing glutamate release
C.N.S