What is the mechanism by which Phenoparbitons and Metalloporphysin act respectively to reduce bilirubin levels in neonatal jaundice
Phenobarbitone:
It induces UDP Glucuromyltransferase
↓
Increase Bilirubin conjugation
Metalloporphyrins:
It is competitive inhibitor of hence oxygenase, which converts hence to bilirubin.
Enhance secretion of conjugated bilirubin and induce bilirubin conjugation by UDP Glucuronyltransferare
Induce bilirubin conjugation by UDP Glucuronyltransferare and competitive inhibition of hemeoxygenase
Induce bilirubin conjugation by UDP Glucuronyltransferare and enhance secretion of conjugated bilirubin
Competitive inhibition of hemeomygenase and enhance secretion of conjugated bilirubin