First step in synthesis of eicosanoids is?
Eicosanoids synthesis is governed by the rate of release of arachidonic acid from membrane lipids in response to appropriate stimuli. These stimuli activate hydrolases, including phospholipase A , which conves arachidonic acid into Prostaglandins, thromboxanes by the COX pathway or Leukotrienes and lipoxins by the LOX pathway Reference: Harpers illustrated biochemistry 31st edition Page no 224
Activation of lipooxygenase
Activation of PGH2 synthetase
Activation of hydrolase
None
Metabolism of lipid