Which of the following substrates links urea cycle to Kreb's cycle?
Arginosuccinate an intermediate of urea cycle is cleaved by argininosuccinate lyase to arginine and fumarate. This fumarate formed in the urea cycle can be funnelled into TCA cycle to be conveed to malate and then to oxaloacetate. Oxaloacetate formed in the krebs cycle can be transaminated to aspaate which is an intermediate of urea cycle. Ref: Textbook of Biochemistry By D M Vasudevan, 3rd Edition, Page 161
Fumarate
Oxaloacetate
Ornithine
Citrullin