Nontoxic form of storage and transpoation of ammonia:
Catabolism of amino acid give rise to ammonia which get transferred to glutamate. From glutamate, NH3 is ultimately taken up by glutamine which is Non-toxic form of storage and transpoation of ammonia in blood (see fig below). Glutamine is neutral in nature and can readily move across cell membrane by facilitative diffusion. Glutamine is formed from glutamate by following reaction:
Aspaic acid
Glutamate
Glutamine
Glutamic acid
Classification and metabolism of amino acids