High plasma protein binding of a drug results in:-
* High plasma protein binding (PPB) of a drug decreases its distribution into tissue and thus lower the volume of distribution. * As only free drug can be metabolized or excreted, high PPB usually increases the duration of action. * With higher PPB, there is more chance of getting displaced by other drugs leading to more drug interactions. * Drugs with high plasma protein binding have lesser glomerular filteration as proteins cannot be filtered across the glomerulus.
Decreased glomerular filtration
High volume of distribution
Lowers duration of action
Less drug interaction
Pharmacokinetics