A one year old child presents with sho stature, lethargy, & constipation. Clinical examination shows a palpable goiter. Laboratory investigations revealed a low T4 and elevated TSH which of the following is the most likely diagnosis.
Child with presence of a palpable goitre ,along with clinical and laboratory features of hypothyroidism suggests a diagnosis of thyroid dyshormonogenesis from the options listed in the question. Ref: Pediatrics By Lloyd J. Brown, Lee Todd Miller page 168.
Thyroid Dyshormonogenesis
Thyroid Dysgenesis
Central Hypothyroidism
TSH Receptor Blocking Antibody