Ciprofloxacin should not be given to an asthmatic using theophylline because:
Ans. (A) Ciprofloxacin inhibits theophylline metabolism(Ref: KDT 8/e p761)Theophylline has a narrow margin of safety (low therapeutic index) Ciprofloxacin inhibits theophylline metabolism and increases its plasma level leading to toxicity. Thus, ciprofloxacin should not be given to an asthmatic using theophylline.
Ciprofloxacin inhibits theophylline metabolism
Theophylline inhibits ciprofloxacin metabolism
Ciprofloxacin decreases effect of theophylline
Theophylline induces metabolism of ciprofloxacin
Chemotherapy: General Principles