Not true regarding Waldenstrom&;s macroglobulinemia,
WALDENSTROM'S MACROGLOBULINEMIAIt is a malignancy of lymphoplasmacytoid cells that secreted IgM. In contrast to myeloma, the disease was associated with lymphadenopathy and hepatosplenomegaly, but the major clinical manifestation was hyperviscosity syndrome.Reference: Harrison&;s principles of Internal Medicine; 19th edition; Chapter 136 Plasma Cell Disorders
Lymphadenopathy is usually present
Blood viscosity increased
Ig M immunoglobulin increased
Hypercalcemia
General pathology