Pancreatitis, pituitary tumor and pheochromocytoma may be associated with:
Answer is A (Medullary Carcinoma of Thyroid); Out of all the histological variants of carcinoma thyroid it is the medullary variant that is associated with multiple endocrinal neoplastic syndromes and hence is the answer here. (No confusion regarding the answer) What puzzles the situation? is the fact that the combination of pancreatitis, pituitary tumor and pheochromocytoma, suggests a diagnosis of MENI syndrome. MEN I has been mentioned to be associated with C cell hyperplasia, and not Medullary carcinoma thyroid. Medullary thyroid carcinomas is a feature of MEN II syndromes. Justification: Medullary carcinoma thyroid arises from parafollicular C cells. C cell hyperplasia thus, may be regarded as a precursor of Medullary carcinoma thyroid. If present in the options, C cell hyperplasia would have been a more correct answer, however in its absence, Medullary thyroid carcinoma is ceainly the option of choice MEN SYNDROMES (Broad Perspective) MEN I (WERMER'S) MEN II Characterized by tumors of Characterized by association of 1. Parathyroid - Medullary carcinoma thyroid & 2. Pituitary - Pheochromocytoma 3. Pancreatic islet cells - Zollinger Ellison syndrome (gastrin) II A (Sipple syndrome) [I B - Insulinoma (Insulin) When associated with hyper- When associated with mucosal - Glucagonoma (Glucagen) parathyroidism neuromas and marfinoid habitus - Verner morrison or watery diarrhea syndrome (pancreatic cholera)
Medullary carcinoma of the thyroid
Papillary carcinoma of the thyroid
Anaplastic carcinoma of the thyroid
Follicular carcinoma of the thyroid