Alpha 2 agonists cause all of the following except:
Ans. (B) Hyperalgesia(Ref: Goodman and Gilman 12th/296; Katzung 12th/176; KDT 8th/e p140)* Alpha 2 agonists cause analgesia, not the hyperalgesia.* Clonidine is used for treatment of hypertension. It decreases blood pressure by acting on central alpha 2 adrenergic receptors.* Dexmedetomidine is another alpha 2 receptor agonist that is used to produce sedation and anxiolytic state by action on alpha 2 receptors in the brain. It can also produce analgesia by acting on alpha 2 receptors in spinal cord.
Analgesia
Hyperalgesia
Sedation
Anxiolysis
Adrenergic System