In full-term neonates, the ductus aeriosus closure is due to
The increasing oxygen saturation and the high aerial po2 causes the muscle of ductus to constrict and eventually closes the ductus aeriosus which eventually becomes ligamentum aeriosum.Anatomical closure of ductus aeriosus occurs within 10 to 25 days.Flow through ductus venosus disappears by the 7th day of postnatal life.
Cardiac output
Prostaglandins
Low pressure CO2
Low pressure O2
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