<?xml version="1.0" encoding="UTF-8"?>
<!-- generated with COPASI 4.30 (Build 235) (http://www.copasi.org) at 2020-12-27T13:01:18Z -->
<?oxygen RNGSchema="http://www.copasi.org/static/schema/CopasiML.rng" type="xml"?>
<COPASI xmlns="http://www.copasi.org/static/schema" versionMajor="4" versionMinor="30" versionDevel="235" copasiSourcesModified="0">
  <ListOfFunctions>
    <Function key="Function_13" name="Mass action (irreversible)" type="MassAction" reversible="false">
      <MiriamAnnotation>
<rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
   <rdf:Description rdf:about="#Function_13">
   <CopasiMT:is rdf:resource="urn:miriam:obo.sbo:SBO:0000041" />
   </rdf:Description>
   </rdf:RDF>
      </MiriamAnnotation>
      <Comment>
        <body xmlns="http://www.w3.org/1999/xhtml">
<b>Mass action rate law for first order irreversible reactions</b>
<p>
Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant.
</p>
</body>
      </Comment>
      <Expression>
        k1*PRODUCT&lt;substrate_i>
      </Expression>
      <ListOfParameterDescriptions>
        <ParameterDescription key="FunctionParameter_80" name="k1" order="0" role="constant"/>
        <ParameterDescription key="FunctionParameter_81" name="substrate" order="1" role="substrate"/>
      </ListOfParameterDescriptions>
    </Function>
    <Function key="Function_3789" name="MM(expl. enzyme)" type="UserDefined" reversible="true">
      <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Function_3789">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        kcat*E*(S-P/Keq)/(S+Kms*(1+P/Kmp))
      </Expression>
      <ListOfParameterDescriptions>
        <ParameterDescription key="FunctionParameter_264" name="S" order="0" role="substrate"/>
        <ParameterDescription key="FunctionParameter_22225" name="P" order="1" role="product"/>
        <ParameterDescription key="FunctionParameter_24357" name="E" order="2" role="modifier"/>
        <ParameterDescription key="FunctionParameter_25757" name="kcat" order="3" role="constant"/>
        <ParameterDescription key="FunctionParameter_25758" name="Keq" order="4" role="constant"/>
        <ParameterDescription key="FunctionParameter_25759" name="Kms" order="5" role="constant"/>
        <ParameterDescription key="FunctionParameter_25760" name="Kmp" order="6" role="constant"/>
      </ListOfParameterDescriptions>
    </Function>
    <Function key="Function_3790" name="Prot synth" type="UserDefined" reversible="false">
      <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Function_3790">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        V*mRNA/(K+mRNA)
      </Expression>
      <ListOfParameterDescriptions>
        <ParameterDescription key="FunctionParameter_25767" name="mRNA" order="0" role="modifier"/>
        <ParameterDescription key="FunctionParameter_25766" name="V" order="1" role="constant"/>
        <ParameterDescription key="FunctionParameter_25765" name="K" order="2" role="constant"/>
      </ListOfParameterDescriptions>
    </Function>
    <Function key="Function_3791" name="mRNA synthesis w/ repressor &amp; inducer" type="UserDefined" reversible="false">
      <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Function_3791">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        V/(1+(Repressor/Kr)^hr +(Ki/Inducer)^hi)
      </Expression>
      <ListOfParameterDescriptions>
        <ParameterDescription key="FunctionParameter_25762" name="Repressor" order="0" role="modifier"/>
        <ParameterDescription key="FunctionParameter_25763" name="Inducer" order="1" role="modifier"/>
        <ParameterDescription key="FunctionParameter_25764" name="V" order="2" role="constant"/>
        <ParameterDescription key="FunctionParameter_25761" name="Kr" order="3" role="constant"/>
        <ParameterDescription key="FunctionParameter_25768" name="hr" order="4" role="constant"/>
        <ParameterDescription key="FunctionParameter_25769" name="Ki" order="5" role="constant"/>
        <ParameterDescription key="FunctionParameter_25770" name="hi" order="6" role="constant"/>
      </ListOfParameterDescriptions>
    </Function>
  </ListOfFunctions>
  <Model key="Model_1" name="3-enzyme linear pathway with gene expression" simulationType="time" timeUnit="s" volumeUnit="ml" areaUnit="m²" lengthUnit="m" quantityUnit="mmol" type="deterministic" avogadroConstant="6.0221417899999999e+23">
    <MiriamAnnotation>
<rdf:RDF
   xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#"
   xmlns:dcterms="http://purl.org/dc/terms/"
   xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
   xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
  <rdf:Description rdf:about="#Model_1">
    <dcterms:bibliographicCitation>
      <rdf:Description>
        <CopasiMT:isDescribedBy rdf:resource="urn:miriam:isbn:9780262277204"/>
      </rdf:Description>
    </dcterms:bibliographicCitation>
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T15:47:31Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
    <dcterms:creator>
      <rdf:Description>
        <vCard:EMAIL>pmendes@uchc.edu</vCard:EMAIL>
        <vCard:N>
          <rdf:Description>
            <vCard:Family>Pedro</vCard:Family>
            <vCard:Given>Mendes</vCard:Given>
          </rdf:Description>
        </vCard:N>
        <vCard:ORG>
          <rdf:Description>
            <vCard:Orgname>University of Connecticut School of Medicine</vCard:Orgname>
          </rdf:Description>
        </vCard:ORG>
      </rdf:Description>
    </dcterms:creator>
  </rdf:Description>
</rdf:RDF>

    </MiriamAnnotation>
    <Comment>
      We attempt to fit 36 parameters of this model against 1 trajectory. This is the problem first proposed in Mendes (2001) "Modeling large scale biological systems from functional genomic data: parameter estimation" in Foundations of Systems Biology (Kitano ed.) MIT Press, 
Cambidge, MA, pp. 163-186.
    </Comment>
    <ListOfCompartments>
      <Compartment key="Compartment_1" name="compartment" simulationType="fixed" dimensionality="3" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Compartment_1">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Compartment>
    </ListOfCompartments>
    <ListOfMetabolites>
      <Metabolite key="Metabolite_365" name="S" simulationType="fixed" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_365">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:04:30Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_364" name="M1" simulationType="reactions" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_364">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:03:48Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_363" name="M2" simulationType="reactions" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_363">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:04:08Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_362" name="P" simulationType="fixed" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_362">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:04:16Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_361" name="E1" simulationType="reactions" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_361">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:04:46Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_360" name="E2" simulationType="reactions" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_360">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:04:52Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_359" name="E3" simulationType="reactions" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_359">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:04:59Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_358" name="G1" simulationType="reactions" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_358">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:05:08Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_357" name="G2" simulationType="reactions" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_357">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:05:22Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
      <Metabolite key="Metabolite_356" name="G3" simulationType="reactions" compartment="Compartment_1" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Metabolite_356">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:05:28Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
      </Metabolite>
    </ListOfMetabolites>
    <ListOfReactions>
      <Reaction key="Reaction_3763" name="R1" reversible="true" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Reaction_3763">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T16:03:16Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_365" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfProducts>
          <Product metabolite="Metabolite_364" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_361" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_5818" name="kcat" value="0.0912698"/>
          <Constant key="Parameter_3918" name="Keq" value="1"/>
          <Constant key="Parameter_3826" name="Kms" value="8.20009e+10"/>
          <Constant key="Parameter_9219" name="Kmp" value="18606"/>
        </ListOfConstants>
        <KineticLaw function="Function_3789" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_264">
              <SourceParameter reference="Metabolite_365"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_22225">
              <SourceParameter reference="Metabolite_364"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_24357">
              <SourceParameter reference="Metabolite_361"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25757">
              <SourceParameter reference="Parameter_5818"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25758">
              <SourceParameter reference="Parameter_3918"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25759">
              <SourceParameter reference="Parameter_3826"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25760">
              <SourceParameter reference="Parameter_9219"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3762" name="R2" reversible="true" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3762">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_364" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfProducts>
          <Product metabolite="Metabolite_363" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_360" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_3920" name="kcat" value="252974"/>
          <Constant key="Parameter_3529" name="Keq" value="1"/>
          <Constant key="Parameter_3874" name="Kms" value="0.00400667"/>
          <Constant key="Parameter_4585" name="Kmp" value="0.633694"/>
        </ListOfConstants>
        <KineticLaw function="Function_3789" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_264">
              <SourceParameter reference="Metabolite_364"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_22225">
              <SourceParameter reference="Metabolite_363"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_24357">
              <SourceParameter reference="Metabolite_360"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25757">
              <SourceParameter reference="Parameter_3920"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25758">
              <SourceParameter reference="Parameter_3529"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25759">
              <SourceParameter reference="Parameter_3874"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25760">
              <SourceParameter reference="Parameter_4585"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3761" name="R3" reversible="true" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3761">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_363" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfProducts>
          <Product metabolite="Metabolite_362" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_359" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_7559" name="kcat" value="3.48331e-12"/>
          <Constant key="Parameter_2787" name="Keq" value="1"/>
          <Constant key="Parameter_2783" name="Kms" value="188640"/>
          <Constant key="Parameter_3961" name="Kmp" value="6.37804e+10"/>
        </ListOfConstants>
        <KineticLaw function="Function_3789" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_264">
              <SourceParameter reference="Metabolite_363"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_22225">
              <SourceParameter reference="Metabolite_362"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_24357">
              <SourceParameter reference="Metabolite_359"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25757">
              <SourceParameter reference="Parameter_7559"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25758">
              <SourceParameter reference="Parameter_2787"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25759">
              <SourceParameter reference="Parameter_2783"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25760">
              <SourceParameter reference="Parameter_3961"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3760" name="R4" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3760">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfProducts>
          <Product metabolite="Metabolite_361" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_358" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_2827" name="V" value="0.000145861"/>
          <Constant key="Parameter_3514" name="K" value="2.92705e-07"/>
        </ListOfConstants>
        <KineticLaw function="Function_3790" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_25767">
              <SourceParameter reference="Metabolite_358"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25766">
              <SourceParameter reference="Parameter_2827"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25765">
              <SourceParameter reference="Parameter_3514"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3759" name="E1d" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="#Reaction_3759">
    <dcterms:created>
      <rdf:Description>
        <dcterms:W3CDTF>2011-05-23T21:20:47Z</dcterms:W3CDTF>
      </rdf:Description>
    </dcterms:created>
  </rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_361" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfConstants>
          <Constant key="Parameter_2808" name="k1" value="1.36308e+10"/>
        </ListOfConstants>
        <KineticLaw function="Function_13" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_80">
              <SourceParameter reference="Parameter_2808"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_81">
              <SourceParameter reference="Metabolite_361"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3758" name="E2s" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3758">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfProducts>
          <Product metabolite="Metabolite_360" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_357" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_3962" name="V" value="1.18071"/>
          <Constant key="Parameter_3825" name="K" value="0.000873788"/>
        </ListOfConstants>
        <KineticLaw function="Function_3790" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_25767">
              <SourceParameter reference="Metabolite_357"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25766">
              <SourceParameter reference="Parameter_3962"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25765">
              <SourceParameter reference="Parameter_3825"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3757" name="E2d" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3757">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_360" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfConstants>
          <Constant key="Parameter_3963" name="k1" value="418.156"/>
        </ListOfConstants>
        <KineticLaw function="Function_13" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_80">
              <SourceParameter reference="Parameter_3963"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_81">
              <SourceParameter reference="Metabolite_360"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3756" name="E3s" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3756">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfProducts>
          <Product metabolite="Metabolite_359" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_356" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_3891" name="V" value="3.91648e+09"/>
          <Constant key="Parameter_3915" name="K" value="0.0590694"/>
        </ListOfConstants>
        <KineticLaw function="Function_3790" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_25767">
              <SourceParameter reference="Metabolite_356"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25766">
              <SourceParameter reference="Parameter_3891"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25765">
              <SourceParameter reference="Parameter_3915"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3755" name="E3d" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3755">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_359" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfConstants>
          <Constant key="Parameter_3930" name="k1" value="5.43385e-08"/>
        </ListOfConstants>
        <KineticLaw function="Function_13" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_80">
              <SourceParameter reference="Parameter_3930"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_81">
              <SourceParameter reference="Metabolite_359"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3754" name="G1s" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3754">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfProducts>
          <Product metabolite="Metabolite_358" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_362" stoichiometry="1"/>
          <Modifier metabolite="Metabolite_365" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_3878" name="V" value="8.0471e-06"/>
          <Constant key="Parameter_4176" name="Kr" value="3.86399e+09"/>
          <Constant key="Parameter_6130" name="hr" value="1.17071"/>
          <Constant key="Parameter_4174" name="Ki" value="128.423"/>
          <Constant key="Parameter_5533" name="hi" value="0.237438"/>
        </ListOfConstants>
        <KineticLaw function="Function_3791" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_25762">
              <SourceParameter reference="Metabolite_362"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25763">
              <SourceParameter reference="Metabolite_365"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25764">
              <SourceParameter reference="Parameter_3878"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25761">
              <SourceParameter reference="Parameter_4176"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25768">
              <SourceParameter reference="Parameter_6130"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25769">
              <SourceParameter reference="Parameter_4174"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25770">
              <SourceParameter reference="Parameter_5533"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3753" name="G1d" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3753">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_358" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfConstants>
          <Constant key="Parameter_4191" name="k1" value="2713.9"/>
        </ListOfConstants>
        <KineticLaw function="Function_13" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_80">
              <SourceParameter reference="Parameter_4191"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_81">
              <SourceParameter reference="Metabolite_358"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3752" name="G2s" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3752">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfProducts>
          <Product metabolite="Metabolite_357" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_362" stoichiometry="1"/>
          <Modifier metabolite="Metabolite_364" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_4205" name="V" value="5.54494e-11"/>
          <Constant key="Parameter_2833" name="Kr" value="0.00165854"/>
          <Constant key="Parameter_2829" name="hr" value="0.58"/>
          <Constant key="Parameter_2832" name="Ki" value="1.99661e-06"/>
          <Constant key="Parameter_2834" name="hi" value="1.04453"/>
        </ListOfConstants>
        <KineticLaw function="Function_3791" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_25762">
              <SourceParameter reference="Metabolite_362"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25763">
              <SourceParameter reference="Metabolite_364"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25764">
              <SourceParameter reference="Parameter_4205"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25761">
              <SourceParameter reference="Parameter_2833"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25768">
              <SourceParameter reference="Parameter_2829"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25769">
              <SourceParameter reference="Parameter_2832"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25770">
              <SourceParameter reference="Parameter_2834"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3751" name="G2d" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3751">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_357" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfConstants>
          <Constant key="Parameter_2838" name="k1" value="6.38701e+06"/>
        </ListOfConstants>
        <KineticLaw function="Function_13" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_80">
              <SourceParameter reference="Parameter_2838"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_81">
              <SourceParameter reference="Metabolite_357"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3750" name="G3s" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3750">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfProducts>
          <Product metabolite="Metabolite_356" stoichiometry="1"/>
        </ListOfProducts>
        <ListOfModifiers>
          <Modifier metabolite="Metabolite_362" stoichiometry="1"/>
          <Modifier metabolite="Metabolite_363" stoichiometry="1"/>
        </ListOfModifiers>
        <ListOfConstants>
          <Constant key="Parameter_3202" name="V" value="17319.1"/>
          <Constant key="Parameter_4195" name="Kr" value="452.268"/>
          <Constant key="Parameter_4203" name="hr" value="0.451442"/>
          <Constant key="Parameter_4204" name="Ki" value="0.140194"/>
          <Constant key="Parameter_4185" name="hi" value="0.936739"/>
        </ListOfConstants>
        <KineticLaw function="Function_3791" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_25762">
              <SourceParameter reference="Metabolite_362"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25763">
              <SourceParameter reference="Metabolite_363"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25764">
              <SourceParameter reference="Parameter_3202"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25761">
              <SourceParameter reference="Parameter_4195"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25768">
              <SourceParameter reference="Parameter_4203"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25769">
              <SourceParameter reference="Parameter_4204"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_25770">
              <SourceParameter reference="Parameter_4185"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
      <Reaction key="Reaction_3749" name="G3d" reversible="false" fast="false" addNoise="false">
        <MiriamAnnotation>
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Reaction_3749">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-22T20:36:54Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ListOfSubstrates>
          <Substrate metabolite="Metabolite_356" stoichiometry="1"/>
        </ListOfSubstrates>
        <ListOfConstants>
          <Constant key="Parameter_4206" name="k1" value="9170.7"/>
        </ListOfConstants>
        <KineticLaw function="Function_13" unitType="Default" scalingCompartment="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]">
          <ListOfCallParameters>
            <CallParameter functionParameter="FunctionParameter_80">
              <SourceParameter reference="Parameter_4206"/>
            </CallParameter>
            <CallParameter functionParameter="FunctionParameter_81">
              <SourceParameter reference="Metabolite_356"/>
            </CallParameter>
          </ListOfCallParameters>
        </KineticLaw>
      </Reaction>
    </ListOfReactions>
    <ListOfModelParameterSets activeSet="ModelParameterSet_1">
      <ModelParameterSet key="ModelParameterSet_1" name="Initial State">
        <MiriamAnnotation>
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#ModelParameterSet_1">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-27T13:00:55Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
        </MiriamAnnotation>
        <ModelParameterGroup cn="String=Initial Time" type="Group">
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression" value="0" type="Model" simulationType="time"/>
        </ModelParameterGroup>
        <ModelParameterGroup cn="String=Initial Compartment Sizes" type="Group">
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment]" value="1" type="Compartment" simulationType="fixed"/>
        </ModelParameterGroup>
        <ModelParameterGroup cn="String=Initial Species Values" type="Group">
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[S]" value="6.0221417900000003e+21" type="Species" simulationType="fixed"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[M1]" value="8.5456216085945752e+20" type="Species" simulationType="reactions"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[M2]" value="5.6285174080355933e+20" type="Species" simulationType="reactions"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[P]" value="6.0221417900000005e+20" type="Species" simulationType="fixed"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[E1]" value="2.4088567159935739e+20" type="Species" simulationType="reactions"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[E2]" value="2.1925733386581279e+20" type="Species" simulationType="reactions"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[E3]" value="1.7739528629097041e+20" type="Species" simulationType="reactions"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[G1]" value="4.0147611933333337e+20" type="Species" simulationType="reactions"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[G2]" value="3.4479048222822833e+20" type="Species" simulationType="reactions"/>
          <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[G3]" value="2.514717648606094e+20" type="Species" simulationType="reactions"/>
        </ModelParameterGroup>
        <ModelParameterGroup cn="String=Initial Global Quantities" type="Group">
        </ModelParameterGroup>
        <ModelParameterGroup cn="String=Kinetic Parameters" type="Group">
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R1]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R1],ParameterGroup=Parameters,Parameter=kcat" value="0.091269799999999998" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R1],ParameterGroup=Parameters,Parameter=Keq" value="1" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R1],ParameterGroup=Parameters,Parameter=Kms" value="82000900000" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R1],ParameterGroup=Parameters,Parameter=Kmp" value="18606" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R2]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R2],ParameterGroup=Parameters,Parameter=kcat" value="252974" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R2],ParameterGroup=Parameters,Parameter=Keq" value="1" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R2],ParameterGroup=Parameters,Parameter=Kms" value="0.0040066700000000004" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R2],ParameterGroup=Parameters,Parameter=Kmp" value="0.63369399999999998" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R3]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R3],ParameterGroup=Parameters,Parameter=kcat" value="3.48331e-12" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R3],ParameterGroup=Parameters,Parameter=Keq" value="1" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R3],ParameterGroup=Parameters,Parameter=Kms" value="188640" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R3],ParameterGroup=Parameters,Parameter=Kmp" value="63780400000" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R4]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R4],ParameterGroup=Parameters,Parameter=V" value="0.000145861" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R4],ParameterGroup=Parameters,Parameter=K" value="2.92705e-07" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E1d]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E1d],ParameterGroup=Parameters,Parameter=k1" value="13630800000" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E2s]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E2s],ParameterGroup=Parameters,Parameter=V" value="1.1807099999999999" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E2s],ParameterGroup=Parameters,Parameter=K" value="0.00087378800000000002" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E2d]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E2d],ParameterGroup=Parameters,Parameter=k1" value="418.15600000000001" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E3s]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E3s],ParameterGroup=Parameters,Parameter=V" value="3916480000" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E3s],ParameterGroup=Parameters,Parameter=K" value="0.059069400000000001" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E3d]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E3d],ParameterGroup=Parameters,Parameter=k1" value="5.43385e-08" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=V" value="8.0470999999999996e-06" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=Kr" value="3863990000" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=hr" value="1.1707099999999999" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=Ki" value="128.423" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=hi" value="0.23743800000000001" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1d]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1d],ParameterGroup=Parameters,Parameter=k1" value="2713.9000000000001" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=V" value="5.5449400000000002e-11" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=Kr" value="0.00165854" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=hr" value="0.57999999999999996" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=Ki" value="1.9966099999999999e-06" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=hi" value="1.04453" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2d]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2d],ParameterGroup=Parameters,Parameter=k1" value="6387010" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=V" value="17319.099999999999" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=Kr" value="452.26799999999997" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=hr" value="0.45144200000000001" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=Ki" value="0.14019400000000001" type="ReactionParameter" simulationType="fixed"/>
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=hi" value="0.93673899999999999" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
          <ModelParameterGroup cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3d]" type="Reaction">
            <ModelParameter cn="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3d],ParameterGroup=Parameters,Parameter=k1" value="9170.7000000000007" type="ReactionParameter" simulationType="fixed"/>
          </ModelParameterGroup>
        </ModelParameterGroup>
      </ModelParameterSet>
    </ListOfModelParameterSets>
    <StateTemplate>
      <StateTemplateVariable objectReference="Model_1"/>
      <StateTemplateVariable objectReference="Metabolite_364"/>
      <StateTemplateVariable objectReference="Metabolite_361"/>
      <StateTemplateVariable objectReference="Metabolite_360"/>
      <StateTemplateVariable objectReference="Metabolite_359"/>
      <StateTemplateVariable objectReference="Metabolite_358"/>
      <StateTemplateVariable objectReference="Metabolite_357"/>
      <StateTemplateVariable objectReference="Metabolite_356"/>
      <StateTemplateVariable objectReference="Metabolite_363"/>
      <StateTemplateVariable objectReference="Metabolite_365"/>
      <StateTemplateVariable objectReference="Metabolite_362"/>
      <StateTemplateVariable objectReference="Compartment_1"/>
    </StateTemplate>
    <InitialState type="initialState">
      0 8.5456216085945752e+20 2.4088567159935739e+20 2.1925733386581279e+20 1.7739528629097041e+20 4.0147611933333337e+20 3.4479048222822833e+20 2.514717648606094e+20 5.6285174080355933e+20 6.0221417900000003e+21 6.0221417900000005e+20 1 
    </InitialState>
  </Model>
  <ListOfTasks>
    <Task key="Task_28" name="Steady-State" type="steadyState" scheduled="false" updateModel="false">
      <Report reference="Report_23" target="" append="1" confirmOverwrite="0"/>
      <Problem>
        <Parameter name="JacobianRequested" type="bool" value="0"/>
        <Parameter name="StabilityAnalysisRequested" type="bool" value="0"/>
      </Problem>
      <Method name="Enhanced Newton" type="EnhancedNewton">
        <Parameter name="Resolution" type="unsignedFloat" value="1.0000000000000001e-09"/>
        <Parameter name="Derivation Factor" type="unsignedFloat" value="0.001"/>
        <Parameter name="Use Newton" type="bool" value="1"/>
        <Parameter name="Use Integration" type="bool" value="1"/>
        <Parameter name="Use Back Integration" type="bool" value="1"/>
        <Parameter name="Accept Negative Concentrations" type="bool" value="0"/>
        <Parameter name="Iteration Limit" type="unsignedInteger" value="50"/>
        <Parameter name="Maximum duration for forward integration" type="unsignedFloat" value="1000000000"/>
        <Parameter name="Maximum duration for backward integration" type="unsignedFloat" value="1000000"/>
        <Parameter name="Target Criterion" type="string" value="Distance and Rate"/>
      </Method>
    </Task>
    <Task key="Task_27" name="Time-Course" type="timeCourse" scheduled="false" updateModel="false">
      <Report reference="Report_13" target="" append="1" confirmOverwrite="1"/>
      <Problem>
        <Parameter name="AutomaticStepSize" type="bool" value="0"/>
        <Parameter name="StepNumber" type="unsignedInteger" value="1"/>
        <Parameter name="StepSize" type="float" value="120"/>
        <Parameter name="Duration" type="float" value="120"/>
        <Parameter name="TimeSeriesRequested" type="bool" value="1"/>
        <Parameter name="OutputStartTime" type="float" value="0"/>
        <Parameter name="Output Event" type="bool" value="0"/>
        <Parameter name="Start in Steady State" type="bool" value="0"/>
        <Parameter name="Use Values" type="bool" value="0"/>
        <Parameter name="Values" type="string" value=""/>
      </Problem>
      <Method name="Deterministic (LSODA)" type="Deterministic(LSODA)">
        <Parameter name="Integrate Reduced Model" type="bool" value="0"/>
        <Parameter name="Relative Tolerance" type="unsignedFloat" value="9.9999999999999995e-07"/>
        <Parameter name="Absolute Tolerance" type="unsignedFloat" value="9.9999999999999998e-13"/>
        <Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
        <Parameter name="Max Internal Step Size" type="unsignedFloat" value="0"/>
      </Method>
    </Task>
    <Task key="Task_26" name="Scan" type="scan" scheduled="true" updateModel="false">
      <Report reference="Report_11" target="3enzyme_nl2sol.out" append="1" confirmOverwrite="0"/>
      <Problem>
        <Parameter name="Subtask" type="unsignedInteger" value="5"/>
        <ParameterGroup name="ScanItems">
          <ParameterGroup name="ScanItem">
            <Parameter name="Number of steps" type="unsignedInteger" value="100"/>
            <Parameter name="Type" type="unsignedInteger" value="0"/>
            <Parameter name="Object" type="cn" value=""/>
          </ParameterGroup>
        </ParameterGroup>
        <Parameter name="Output in subtask" type="bool" value="0"/>
        <Parameter name="Adjust initial conditions" type="bool" value="0"/>
        <Parameter name="Continue on Error" type="bool" value="0"/>
      </Problem>
      <Method name="Scan Framework" type="ScanFramework">
      </Method>
    </Task>
    <Task key="Task_25" name="Elementary Flux Modes" type="fluxMode" scheduled="false" updateModel="false">
      <Report reference="Report_21" target="" append="1" confirmOverwrite="0"/>
      <Problem>
      </Problem>
      <Method name="EFM Algorithm" type="EFMAlgorithm">
      </Method>
    </Task>
    <Task key="Task_24" name="Optimization" type="optimization" scheduled="false" updateModel="false">
      <Report reference="Report_20" target="" append="1" confirmOverwrite="0"/>
      <Problem>
        <Parameter name="Subtask" type="cn" value="CN=Root,Vector=TaskList[Steady-State]"/>
        <ParameterText name="ObjectiveExpression" type="expression">
          
        </ParameterText>
        <Parameter name="Maximize" type="bool" value="0"/>
        <Parameter name="Randomize Start Values" type="bool" value="0"/>
        <Parameter name="Calculate Statistics" type="bool" value="1"/>
        <ParameterGroup name="OptimizationItemList">
        </ParameterGroup>
        <ParameterGroup name="OptimizationConstraintList">
        </ParameterGroup>
      </Problem>
      <Method name="Random Search" type="RandomSearch">
        <Parameter name="Log Verbosity" type="unsignedInteger" value="0"/>
        <Parameter name="Number of Iterations" type="unsignedInteger" value="100000"/>
        <Parameter name="Random Number Generator" type="unsignedInteger" value="1"/>
        <Parameter name="Seed" type="unsignedInteger" value="0"/>
      </Method>
    </Task>
    <Task key="Task_23" name="Parameter Estimation" type="parameterFitting" scheduled="false" updateModel="false">
      <Report reference="Report_19" target="" append="0" confirmOverwrite="0"/>
      <Problem>
        <Parameter name="Maximize" type="bool" value="0"/>
        <Parameter name="Randomize Start Values" type="bool" value="0"/>
        <Parameter name="Calculate Statistics" type="bool" value="0"/>
        <ParameterGroup name="OptimizationItemList">
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R1],ParameterGroup=Parameters,Parameter=kcat,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R1],ParameterGroup=Parameters,Parameter=Kms,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R1],ParameterGroup=Parameters,Parameter=Kmp,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R2],ParameterGroup=Parameters,Parameter=kcat,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R2],ParameterGroup=Parameters,Parameter=Kms,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R2],ParameterGroup=Parameters,Parameter=Kmp,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R3],ParameterGroup=Parameters,Parameter=kcat,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R3],ParameterGroup=Parameters,Parameter=Kms,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R3],ParameterGroup=Parameters,Parameter=Kmp,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R4],ParameterGroup=Parameters,Parameter=K,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[R4],ParameterGroup=Parameters,Parameter=V,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E1d],ParameterGroup=Parameters,Parameter=k1,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E2s],ParameterGroup=Parameters,Parameter=V,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E2s],ParameterGroup=Parameters,Parameter=K,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E2d],ParameterGroup=Parameters,Parameter=k1,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E3s],ParameterGroup=Parameters,Parameter=K,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E3s],ParameterGroup=Parameters,Parameter=V,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[E3d],ParameterGroup=Parameters,Parameter=k1,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=V,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=Kr,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="0.1"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=hr,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="1"/>
            <Parameter name="UpperBound" type="cn" value="10"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=Ki,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="0.1"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1s],ParameterGroup=Parameters,Parameter=hi,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="1"/>
            <Parameter name="UpperBound" type="cn" value="10"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G1d],ParameterGroup=Parameters,Parameter=k1,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=V,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=Kr,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="0.1"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=hr,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="1"/>
            <Parameter name="UpperBound" type="cn" value="10"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=Ki,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="0.1"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2s],ParameterGroup=Parameters,Parameter=hi,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="1"/>
            <Parameter name="UpperBound" type="cn" value="10"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G2d],ParameterGroup=Parameters,Parameter=k1,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=V,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=Kr,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="0.1"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=hr,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="1"/>
            <Parameter name="UpperBound" type="cn" value="10"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=Ki,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="0.1"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3s],ParameterGroup=Parameters,Parameter=hi,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="1"/>
            <Parameter name="UpperBound" type="cn" value="10"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
          <ParameterGroup name="FitItem">
            <ParameterGroup name="Affected Experiments">
            </ParameterGroup>
            <Parameter name="LowerBound" type="cn" value="1e-12"/>
            <Parameter name="ObjectCN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Reactions[G3d],ParameterGroup=Parameters,Parameter=k1,Reference=Value"/>
            <Parameter name="StartValue" type="float" value="0.001"/>
            <Parameter name="UpperBound" type="cn" value="1e6"/>
            <ParameterGroup name="Affected Cross Validation Experiments">
            </ParameterGroup>
          </ParameterGroup>
        </ParameterGroup>
        <ParameterGroup name="OptimizationConstraintList">
        </ParameterGroup>
        <Parameter name="Steady-State" type="cn" value="CN=Root,Vector=TaskList[Steady-State]"/>
        <Parameter name="Time-Course" type="cn" value="CN=Root,Vector=TaskList[Time-Course]"/>
        <Parameter name="Create Parameter Sets" type="bool" value="0"/>
        <Parameter name="Use Time Sens" type="bool" value="0"/>
        <Parameter name="Time-Sens" type="cn" value=""/>
        <ParameterGroup name="Experiment Set">
          <ParameterGroup name="Experiment">
            <Parameter name="Data is Row Oriented" type="bool" value="1"/>
            <Parameter name="Experiment Type" type="unsignedInteger" value="1"/>
            <Parameter name="File Name" type="file" value="linear3.perturbations.dyn"/>
            <Parameter name="First Row" type="unsignedInteger" value="1"/>
            <Parameter name="Key" type="key" value="Experiment_0"/>
            <Parameter name="Last Row" type="unsignedInteger" value="20"/>
            <Parameter name="Number of Columns" type="unsignedInteger" value="9"/>
            <ParameterGroup name="Object Map">
              <ParameterGroup name="0">
                <Parameter name="Role" type="unsignedInteger" value="3"/>
              </ParameterGroup>
              <ParameterGroup name="1">
                <Parameter name="Object CN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[M1],Reference=Concentration"/>
                <Parameter name="Role" type="unsignedInteger" value="2"/>
              </ParameterGroup>
              <ParameterGroup name="2">
                <Parameter name="Object CN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[M2],Reference=Concentration"/>
                <Parameter name="Role" type="unsignedInteger" value="2"/>
              </ParameterGroup>
              <ParameterGroup name="3">
                <Parameter name="Object CN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[E1],Reference=Concentration"/>
                <Parameter name="Role" type="unsignedInteger" value="2"/>
              </ParameterGroup>
              <ParameterGroup name="4">
                <Parameter name="Object CN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[E2],Reference=Concentration"/>
                <Parameter name="Role" type="unsignedInteger" value="2"/>
              </ParameterGroup>
              <ParameterGroup name="5">
                <Parameter name="Object CN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[E3],Reference=Concentration"/>
                <Parameter name="Role" type="unsignedInteger" value="2"/>
              </ParameterGroup>
              <ParameterGroup name="6">
                <Parameter name="Object CN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[G1],Reference=Concentration"/>
                <Parameter name="Role" type="unsignedInteger" value="2"/>
              </ParameterGroup>
              <ParameterGroup name="7">
                <Parameter name="Object CN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[G2],Reference=Concentration"/>
                <Parameter name="Role" type="unsignedInteger" value="2"/>
              </ParameterGroup>
              <ParameterGroup name="8">
                <Parameter name="Object CN" type="cn" value="CN=Root,Model=3-enzyme linear pathway with gene expression,Vector=Compartments[compartment],Vector=Metabolites[G3],Reference=Concentration"/>
                <Parameter name="Role" type="unsignedInteger" value="2"/>
              </ParameterGroup>
            </ParameterGroup>
            <Parameter name="Row containing Names" type="unsignedInteger" value="4294967295"/>
            <Parameter name="Separator" type="string" value="&#x09;"/>
            <Parameter name="Weight Method" type="unsignedInteger" value="0"/>
            <Parameter name="Normalize Weights per Experiment" type="bool" value="1"/>
          </ParameterGroup>
        </ParameterGroup>
        <ParameterGroup name="Validation Set">
          <Parameter name="Weight" type="unsignedFloat" value="1"/>
          <Parameter name="Threshold" type="unsignedInteger" value="5"/>
        </ParameterGroup>
      </Problem>
      <Method name="NL2SOL" type="NL2SOL">
        <Parameter name="Log Verbosity" type="unsignedInteger" value="0"/>
        <Parameter name="Iteration Limit" type="unsignedInteger" value="2000"/>
      </Method>
    </Task>
    <Task key="Task_22" name="Metabolic Control Analysis" type="metabolicControlAnalysis" scheduled="false" updateModel="false">
      <Report reference="Report_18" target="" append="1" confirmOverwrite="0"/>
      <Problem>
        <Parameter name="Steady-State" type="key" value="Task_28"/>
      </Problem>
      <Method name="MCA Method (Reder)" type="MCAMethod(Reder)">
        <Parameter name="Modulation Factor" type="unsignedFloat" value="1.0000000000000001e-09"/>
        <Parameter name="Use Reder" type="bool" value="1"/>
        <Parameter name="Use Smallbone" type="bool" value="1"/>
      </Method>
    </Task>
    <Task key="Task_21" name="Lyapunov Exponents" type="lyapunovExponents" scheduled="false" updateModel="false">
      <Report reference="Report_17" target="" append="1" confirmOverwrite="0"/>
      <Problem>
        <Parameter name="ExponentNumber" type="unsignedInteger" value="3"/>
        <Parameter name="DivergenceRequested" type="bool" value="1"/>
        <Parameter name="TransientTime" type="float" value="0"/>
      </Problem>
      <Method name="Wolf Method" type="WolfMethod">
        <Parameter name="Orthonormalization Interval" type="unsignedFloat" value="1"/>
        <Parameter name="Overall time" type="unsignedFloat" value="1000"/>
        <Parameter name="Relative Tolerance" type="unsignedFloat" value="9.9999999999999995e-07"/>
        <Parameter name="Absolute Tolerance" type="unsignedFloat" value="9.9999999999999998e-13"/>
        <Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
      </Method>
    </Task>
    <Task key="Task_20" name="Time Scale Separation Analysis" type="timeScaleSeparationAnalysis" scheduled="false" updateModel="false">
      <Report reference="Report_16" target="" append="1" confirmOverwrite="0"/>
      <Problem>
        <Parameter name="StepNumber" type="unsignedInteger" value="100"/>
        <Parameter name="StepSize" type="float" value="0.01"/>
        <Parameter name="Duration" type="float" value="1"/>
        <Parameter name="TimeSeriesRequested" type="bool" value="1"/>
        <Parameter name="OutputStartTime" type="float" value="0"/>
      </Problem>
      <Method name="ILDM (LSODA,Deuflhard)" type="TimeScaleSeparation(ILDM,Deuflhard)">
        <Parameter name="Deuflhard Tolerance" type="unsignedFloat" value="9.9999999999999995e-07"/>
      </Method>
    </Task>
    <Task key="Task_19" name="Sensitivities" type="sensitivities" scheduled="false" updateModel="false">
      <Report reference="Report_15" target="" append="1" confirmOverwrite="0"/>
      <Problem>
        <Parameter name="SubtaskType" type="unsignedInteger" value="1"/>
        <ParameterGroup name="TargetFunctions">
          <Parameter name="SingleObject" type="cn" value=""/>
          <Parameter name="ObjectListType" type="unsignedInteger" value="7"/>
        </ParameterGroup>
        <ParameterGroup name="ListOfVariables">
          <ParameterGroup name="Variables">
            <Parameter name="SingleObject" type="cn" value=""/>
            <Parameter name="ObjectListType" type="unsignedInteger" value="41"/>
          </ParameterGroup>
          <ParameterGroup name="Variables">
            <Parameter name="SingleObject" type="cn" value=""/>
            <Parameter name="ObjectListType" type="unsignedInteger" value="0"/>
          </ParameterGroup>
        </ParameterGroup>
      </Problem>
      <Method name="Sensitivities Method" type="SensitivitiesMethod">
        <Parameter name="Delta factor" type="unsignedFloat" value="0.001"/>
        <Parameter name="Delta minimum" type="unsignedFloat" value="9.9999999999999998e-13"/>
      </Method>
    </Task>
    <Task key="Task_18" name="Moieties" type="moieties" scheduled="false" updateModel="false">
      <Report reference="Report_12" target="" append="1" confirmOverwrite="1"/>
      <Problem>
      </Problem>
      <Method name="Householder Reduction" type="Householder">
      </Method>
    </Task>
    <Task key="Task_17" name="Linear Noise Approximation" type="linearNoiseApproximation" scheduled="false" updateModel="false">
      <Report reference="Report_14" target="" append="1" confirmOverwrite="1"/>
      <Problem>
        <Parameter name="Steady-State" type="key" value="Task_28"/>
      </Problem>
      <Method name="Linear Noise Approximation" type="LinearNoiseApproximation">
      </Method>
    </Task>
    <Task key="Task_16" name="Cross Section" type="crosssection" scheduled="false" updateModel="false">
      <Problem>
        <Parameter name="AutomaticStepSize" type="bool" value="0"/>
        <Parameter name="StepNumber" type="unsignedInteger" value="100"/>
        <Parameter name="StepSize" type="float" value="0.01"/>
        <Parameter name="Duration" type="float" value="1"/>
        <Parameter name="TimeSeriesRequested" type="bool" value="1"/>
        <Parameter name="OutputStartTime" type="float" value="0"/>
        <Parameter name="Output Event" type="bool" value="0"/>
        <Parameter name="Start in Steady State" type="bool" value="0"/>
        <Parameter name="Use Values" type="bool" value="0"/>
        <Parameter name="Values" type="string" value=""/>
        <Parameter name="LimitCrossings" type="bool" value="0"/>
        <Parameter name="NumCrossingsLimit" type="unsignedInteger" value="0"/>
        <Parameter name="LimitOutTime" type="bool" value="0"/>
        <Parameter name="LimitOutCrossings" type="bool" value="0"/>
        <Parameter name="PositiveDirection" type="bool" value="1"/>
        <Parameter name="NumOutCrossingsLimit" type="unsignedInteger" value="0"/>
        <Parameter name="LimitUntilConvergence" type="bool" value="0"/>
        <Parameter name="ConvergenceTolerance" type="float" value="0"/>
        <Parameter name="Threshold" type="float" value="0"/>
        <Parameter name="DelayOutputUntilConvergence" type="bool" value="0"/>
        <Parameter name="OutputConvergenceTolerance" type="float" value="0"/>
        <ParameterText name="TriggerExpression" type="expression">
          
        </ParameterText>
        <Parameter name="SingleVariable" type="cn" value=""/>
      </Problem>
      <Method name="Deterministic (LSODA)" type="Deterministic(LSODA)">
        <Parameter name="Integrate Reduced Model" type="bool" value="0"/>
        <Parameter name="Relative Tolerance" type="unsignedFloat" value="9.9999999999999995e-07"/>
        <Parameter name="Absolute Tolerance" type="unsignedFloat" value="9.9999999999999998e-13"/>
        <Parameter name="Max Internal Steps" type="unsignedInteger" value="100000"/>
        <Parameter name="Max Internal Step Size" type="unsignedFloat" value="0"/>
      </Method>
    </Task>
    <Task key="Task_29" name="Time-Course Sensitivities" type="timeSensitivities" scheduled="false" updateModel="false">
      <Problem>
        <Parameter name="AutomaticStepSize" type="bool" value="0"/>
        <Parameter name="StepNumber" type="unsignedInteger" value="100"/>
        <Parameter name="StepSize" type="float" value="0.01"/>
        <Parameter name="Duration" type="float" value="1"/>
        <Parameter name="TimeSeriesRequested" type="bool" value="1"/>
        <Parameter name="OutputStartTime" type="float" value="0"/>
        <Parameter name="Output Event" type="bool" value="0"/>
        <Parameter name="Start in Steady State" type="bool" value="0"/>
        <Parameter name="Use Values" type="bool" value="0"/>
        <Parameter name="Values" type="string" value=""/>
        <ParameterGroup name="ListOfParameters">
        </ParameterGroup>
        <ParameterGroup name="ListOfTargets">
        </ParameterGroup>
      </Problem>
      <Method name="LSODA Sensitivities" type="Sensitivities(LSODA)">
        <Parameter name="Integrate Reduced Model" type="bool" value="0"/>
        <Parameter name="Relative Tolerance" type="unsignedFloat" value="9.9999999999999995e-07"/>
        <Parameter name="Absolute Tolerance" type="unsignedFloat" value="9.9999999999999998e-13"/>
        <Parameter name="Max Internal Steps" type="unsignedInteger" value="10000"/>
        <Parameter name="Max Internal Step Size" type="unsignedFloat" value="0"/>
      </Method>
    </Task>
  </ListOfTasks>
  <ListOfReports>
    <Report key="Report_23" name="Steady-State" taskType="steadyState" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Footer>
        <Object cn="CN=Root,Vector=TaskList[Steady-State]"/>
      </Footer>
    </Report>
    <Report key="Report_21" name="Elementary Flux Modes" taskType="fluxMode" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Footer>
        <Object cn="CN=Root,Vector=TaskList[Elementary Flux Modes],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_20" name="Optimization" taskType="optimization" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Optimization],Object=Description"/>
        <Object cn="String=\[Function Evaluations\]"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="String=\[Best Value\]"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="String=\[Best Parameters\]"/>
      </Header>
      <Body>
        <Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Function Evaluations"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Best Value"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="CN=Root,Vector=TaskList[Optimization],Problem=Optimization,Reference=Best Parameters"/>
      </Body>
      <Footer>
        <Object cn="String=&#x0a;"/>
        <Object cn="CN=Root,Vector=TaskList[Optimization],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_19" name="Parameter Estimation" taskType="parameterFitting" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Object=Description"/>
        <Object cn="String=\[Function Evaluations\]"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="String=\[Best Value\]"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="String=\[Best Parameters\]"/>
      </Header>
      <Body>
        <Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Function Evaluations"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Value"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Problem=Parameter Estimation,Reference=Best Parameters"/>
      </Body>
      <Footer>
        <Object cn="String=&#x0a;"/>
        <Object cn="CN=Root,Vector=TaskList[Parameter Estimation],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_18" name="Metabolic Control Analysis" taskType="metabolicControlAnalysis" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Metabolic Control Analysis],Object=Description"/>
      </Header>
      <Footer>
        <Object cn="String=&#x0a;"/>
        <Object cn="CN=Root,Vector=TaskList[Metabolic Control Analysis],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_17" name="Lyapunov Exponents" taskType="lyapunovExponents" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Lyapunov Exponents],Object=Description"/>
      </Header>
      <Footer>
        <Object cn="String=&#x0a;"/>
        <Object cn="CN=Root,Vector=TaskList[Lyapunov Exponents],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_16" name="Time Scale Separation Analysis" taskType="timeScaleSeparationAnalysis" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Time Scale Separation Analysis],Object=Description"/>
      </Header>
      <Footer>
        <Object cn="String=&#x0a;"/>
        <Object cn="CN=Root,Vector=TaskList[Time Scale Separation Analysis],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_15" name="Sensitivities" taskType="sensitivities" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Sensitivities],Object=Description"/>
      </Header>
      <Footer>
        <Object cn="String=&#x0a;"/>
        <Object cn="CN=Root,Vector=TaskList[Sensitivities],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_14" name="Linear Noise Approximation" taskType="linearNoiseApproximation" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Linear Noise Approximation],Object=Description"/>
      </Header>
      <Footer>
        <Object cn="String=&#x0a;"/>
        <Object cn="CN=Root,Vector=TaskList[Linear Noise Approximation],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_13" name="Time-Course" taskType="timeCourse" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Time-Course],Object=Description"/>
      </Header>
      <Footer>
        <Object cn="CN=Root,Vector=TaskList[Time-Course],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_12" name="Moieties" taskType="moieties" separator="&#x09;" precision="6">
      <Comment>
        Automatically generated report.
      </Comment>
      <Header>
        <Object cn="CN=Root,Vector=TaskList[Moieties],Object=Description"/>
      </Header>
      <Footer>
        <Object cn="String=&#x0a;"/>
        <Object cn="CN=Root,Vector=TaskList[Moieties],Object=Result"/>
      </Footer>
    </Report>
    <Report key="Report_11" name="Speed test (scan)" taskType="scan" separator="&#x09;" precision="8">
      <Comment>
      </Comment>
      <Header>
        <Object cn="CN=Root,CN=Information,String=COPASI Version"/>
        <Object cn="Separator=&#x09;"/>
        <Object cn="CN=Root,CN=Information,Timer=Current Date/Time"/>
      </Header>
      <Footer>
        <Object cn="CN=Root,Timer=CPU Time"/>
      </Footer>
    </Report>
  </ListOfReports>
  <GUI>
  </GUI>
  <ListOfUnitDefinitions>
    <UnitDefinition key="Unit_1" name="meter" symbol="m">
      <MiriamAnnotation>
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Unit_0">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-26T20:53:32Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        m
      </Expression>
    </UnitDefinition>
    <UnitDefinition key="Unit_5" name="second" symbol="s">
      <MiriamAnnotation>
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Unit_4">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-26T20:53:32Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        s
      </Expression>
    </UnitDefinition>
    <UnitDefinition key="Unit_13" name="Avogadro" symbol="Avogadro">
      <MiriamAnnotation>
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Unit_12">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-26T20:53:32Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        Avogadro
      </Expression>
    </UnitDefinition>
    <UnitDefinition key="Unit_17" name="item" symbol="#">
      <MiriamAnnotation>
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Unit_16">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-26T20:53:32Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        #
      </Expression>
    </UnitDefinition>
    <UnitDefinition key="Unit_35" name="liter" symbol="l">
      <MiriamAnnotation>
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Unit_34">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-26T20:53:32Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        0.001*m^3
      </Expression>
    </UnitDefinition>
    <UnitDefinition key="Unit_41" name="mole" symbol="mol">
      <MiriamAnnotation>
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#Unit_40">
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2020-12-26T20:53:32Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
      </MiriamAnnotation>
      <Expression>
        Avogadro*#
      </Expression>
    </UnitDefinition>
  </ListOfUnitDefinitions>
</COPASI>
