Datasets:

hcw-00

/

demo

like 0

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[ "PY:", "1995", "LA:", "ENGLISH", "AB:", "Pulmonary", "eosinophilic", "granuloma", "is", "a", "disorder", "caused", "by", "localized", "collections", "of", "proliferating", "histiocytes", "in", "the", "lung.", "Little", "is", "known", "about", "its", "etiology", "except", "that", "the", "majority", "(38", "to", "97%)", "of", "patients", "are", "current", "or", "ex-smokers,", "making", "the", "potential", "etiologic", "role", "of", "tobacco", "products", "an", "important", "area", "for", "research.", "Tobacco", "glycoprotein", "(TGP)", "is", "a", "potent", "immunostimulator", "that", "has", "been", "isolated", "from", "cigarette", "smoke.", "TGP-specific", "lymphocyte", "proliferation,", "and", "cytokine", "production", "in", "vitro,", "were", "measured", "in", "three", "patients", "with", "pulmonary", "eosinopbilic", "granuloma", "in", "remission", "and", "in", "three", "closely", "matched", "normal", "subjects", "with", "similar", "smoking", "histories.", "One", "patient", "with", "eosinophilic", "granuloma", "of", "bone", "and", "a", "matched", "control", "subject", "were", "also", "studied.", "Peripheral", "blood", "mononuclear", "cells", "were", "cultured", "with", "TGP,", "the", "recall", "antigen", "streptokinase", "(SK),", "and", "the", "mitogen", "concanavalin", "A", "(Con", "A).", "All", "three", "of", "the", "patients", "with", "pulmonary", "eosinophilic", "granuloma", "exhibited", "significant", "decreases", "in", "lymphocyte", "stimulation", "to", "TGP,", "despite", "normal", "responses", "to", "SK", "and", "Con", "A.", "In", "contrast,", "the", "response", "of", "the", "patient", "with", "eosinophilic", "granuloma", "of", "bone", "was", "higher", "than", "her", "matched", "control.", "The", "mean", "responses", "of", "the", "patients", "with", "pulmonary", "eosinophilic", "granuloma", "to", "TGP", "was", "significantly", "lower", "than", "the", "mean", "of", "nondiseased", "smokers", "or", "of", "normal", "nonsmokers.", "Twenty-four-hour", "culture", "supernatants", "were", "collected", "and", "assayed", "for", "cytokine", "levels", "(IL-1,", "IL-2,", "and", "TL-", "6).", "TGP-stimulated", "IL-2", "production", "was", "significantly", "lower", "in", "the", "patients", "with", "pulmonary", "eosinophilic", "granuloma", "than", "in", "the", "normal", "subjects,", "confirming", "the", "reduced", "T-cell", "proliferative", "response.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS)", "MESH:", "Adult-;", "Analysis-of-Variance;", "Cell-Division-drug-effects;", "Cells,-Cultured;", "Comparative-Study;", "Eosinophilic-Granuloma-etiology;", "Female-;", "Human-;", "Interleukins-blood;", "Lung-Diseases-etiology;", "Lymphocytes-cytology;", "Male-;", "Middle-Age;", "Smoking-blood;", "Statistics,-Nonparametric;", "Support,-Non-", "U.S.-Gov't;", "Support,-U.S.-Gov't,-P.H.S.", "MESH:", "*Eosinophilic-Granuloma-blood;", "*Glycoproteins-pharmacology;", "*Lung-Diseases-blood;", "*Lymphocytes-drug-effects;", "*Tobacco-", "PT:", "JOURNAL-ARTICLE", "RN:", "0", "(Glycoproteins);", "O", "(Interleukins)", "ISSN:", "1073-449X", "CO:", "BZS", "UDh:", "9504", "AN:", "95111735", "Record", "21", "of", "34", "TOXLINE", "1/94-12/97", "SF:", "TOXBIB", "TI:", "The", "role", "of", "airway", "mucus", "in", "pulmonary", "toxicology.", "AU:", "Samet-JM;", "Cheng-PW", "AD:", "Center", "for", "Environmental", "Medicine", "and", "Lung", "Biology,", "University", "of", "North", "Carolina", "at", "Chapel", "Hill,", "SO:", "Environ-Health-Perspect;", "VOL", "102", "Suppl", "2,", "1994,", "P89-103", "(REF:", "178)", "PY:", "1994", "Support,-U.S.-Gov't,-P.H.S.", "MESH:", "*Air-Pollutants-adverse-effects;", "*Lung-drug-effects;", "*Lung-Diseases-chemically-induced;", "*Mucus-physiclogy", "LA:", "ENGLISH", "AB:", "Airway", "mucus", "is", "a", "complex", "airway", "secretion", "whose", "primary", "function", "as", "part", "of", "the", "mucociliary", "transport", "mechanism", "is", "to", "to", "serve", "as", "renewable", "and", "transportable", "barrier", "against", "inhaled", "particulates", "and", "toxic", "agents.", "The", "rheologic", "properties", "necessary", "for", "this", "function", "are", "imparted", "by", "glycoproteins,", "or", "mucins.", "Some", "respiratory", "disease", "states,", "e.g.,", "asthma,", "cystic", "fibrosis,", "and", "bronchitis,", "are", "characterized", "by", "quantitative", "and", "qualitative", "changes", "in", "mucus", "biosynthesis", "that", "contribute", "to", "pulmonary", "pathology.", "Similar", "alterations", "in", "various", "aspects", "of", "mucin", "biochemistry", "and", "biophysics,", "leading", "to", "mucus", "hypersecretion", "and", "altered", "mucus", "rheology,", "result", "from", "inhalation", "of", "certain", "air", "pollutants,", "such", "as", "ozone,", "sulfur", "dioxide,", "nitrogen", "dioxide,", "and", "cigarette", "smoke.", "The", "consequences", "of", "these", "pollutant-induced", "alterations", "in", "mucus", "biology", "are", "discussed", "in", "the", "context", "of", "pulmonary", "pathophysiology", "and", "toxicology.", "MESH:", "Animal-;", "Carbohydrate-Sequence;", "Human-;", "Lung-Diseases-physiopathology;", "Molecular-Sequence-", "Data;", "Mucus-chemistry;", "Mucus-cytology;", "Support,-Non-U.S.-Gov't;", "Support,-U.S.-Gov't,-Non-P.H.S.;", "209s2Zreloz" ]

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