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license: cc-by-4.0 |
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## Citation |
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DepMap, Broad; Corsello, Steven; Kocak, Mustafa; Golub, Todd (2019). PRISM Repurposing 19Q4 Dataset. figshare. Dataset. |
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Current dataset: [https://doi.org/10.6084/m9.figshare.9393293.v4](https://doi.org/10.6084/m9.figshare.9393293.v4) |
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General guidance: [https://doi.org/10.1101/730119](https://doi.org/10.1101/730119) |
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## Dataset Fields |
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- **broad_id**: ID used to identify drug-batch combinations |
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- **name**: Name of the drug |
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- **depmap_id**: ID to identify a cell line |
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- **ccle_name**: ID to identify a cell line |
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- **screen_id**: ID to identify a screen |
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- **upper_limit**: Limit of the curve as dose approaches infinity |
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- **lower_limit**: Limit of the curve as dose approaches zero |
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- **slope**: Slope of the dose-response curve |
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- **r2**: Goodness of fit measure between dose-response curve and replicate viability data |
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- **auc**: Area under the dose-response curve |
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- **ec50**: Dose at the inflection point of the dose-response curve |
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- **ic50**: Dose that corresponds to a viability of 50 on the dose-response curve |
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- **moa**: Broad Repurposing Hub mechanism of action annotation |
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- **target**: Broad Repurposing Hub gene target annotation |
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- **disease_area**: Broad Repurposing Hub disease area annotation |
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- **indication**: Broad Repurposing Hub indication annotation |
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- **smiles**: Simplified Molecular Input Line Entry System (SMILES) molecular identifier |
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- **phase**: Broad Repurposing Hub latest clinical phase annotation |
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- **passed_str_profiling**: Indicator for problems identified by STR profiling |
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