abdelmo/pubmed-dataset · Datasets at Hugging Face

[Epidemiology of accidental falls in the elderly].

ns. There remains an information gap on the incidence of falls and fall-related sequelae without hospitalization in Germany.Facing; the demographic transgression the prevention of falls and fall-related injuries gains a high priority. Operative management and rehabilitation procedures for elderly trauma patients should be further evaluated and improved.

10666853

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[Thoracoscopic interventions in deformities of the thoracic spine].

We prospectively studied 9 patients with deformities of the thoracic spine who underwent thoracoscopic surgery to critically evaluate the benefits and limitations of thoracoscopy.Seven patients with deformities of the thoracic spine (5 scoliosis; 2 kyphosis) underwent a thoracoscopic release and posterior correction and fusion in a single stage. In one case of a crankshaft-phenomenon a thoracoscopic epiphyseodesis und in another case of a posttraumatic kyphosis a thoracoscopic instrumentation and fusion wer

10666856

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[Thoracoscopic interventions in deformities of the thoracic spine].

e performed. The average age was 21 years; the follow-up was 18 months with a minimum of 12 months. The perioperative data including complications were collected and a radiographic analysis concerning curve correction was carried out.The scoliotic curves measured preoperatively 84 degrees on average with a Cobb angle of 62 degrees on the traction films and were corrected by 57% to averagely 36 degrees at follow-up. In the two cases of Scheuermann kyphosis a preoperative kyphosis of 94 degrees respectively 8

10666856

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[Thoracoscopic interventions in deformities of the thoracic spine].

2 degrees was corrected to 52 degrees respectively 58 degrees. Between 4 and 5 discs were excised with an average operative time of 160 min and a blood loss of 380 ml. A conversion to open thoracotomy was not necessary in any case. There were no intraoperative neurovascular complications.Thoracoscopic procedures in deformities of the thoracic spine are technically demanding; however; it is a minimally invasive procedure with a reduced approach-related morbidity compared to open thoracotomy. The indications

10666856

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[Thoracoscopic interventions in deformities of the thoracic spine].

for a thoracoscopic release are rigid kyphosis and scoliosis with rigid curves between 80 and 90 degrees Cobb angle in which an anterior correction and instrumentation alone is not considered.

10666856

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[Hemostaseology and pre-eclampsia].

nan

10666865

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[Fractures of the upper extremity in the elderly].

The primary goal in treating fractures in elderly persons is safe and rapid restoration of their functional capabilities to secure independence in everyday activities. The intention of this paper is to present an overview of treatment principles useful in this age group.We analysed a series of 404 patients above the age of 70 years who underwent surgery for fractures of the arm between 1981 and 1997.Diaphyseal fractures are less frequent in this age group and their treatment does not differ significantly fr

10666854

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[Fractures of the upper extremity in the elderly].

om principles established for younger patients. The majority of fractures of the proximal humerus and the distal radius can be treated by conservative means. Unstable fractures are frequent in the distal humerus and the olecranon requiring operative reduction and osteosynthesis.Preferred operative techniques in aged persons inflict minimal surgical trauma and have a low rate of complications and secondary interventions. In contrast; anatomical reconstruction has the highest priority in younger individuals.

10666854

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[Pre-eclampsia--endothelial damage of endothelial activation?].

There is considerable evidence that endothelial damage; followed by the release of vasoactive substances contributes to the pathophysiology of preeclampsia. Because of controversial experiences in literature we wanted to evaluate the potential cytotoxic effect of preeclamptic sera on cultured endothelial cells. Therefore cultured human umbilical vein endothelial cells (HUVEC) were stimulated with sera obtained from preeclamptic patients; while sera from normotensive pregnant and nonpregnant women served as

10666866

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[Pre-eclampsia--endothelial damage of endothelial activation?].

controls. To prove the viability of these cells we performed ethidiumbromide/acridinorange immunostaining and determined t-PA/PAI-1 release into the supernatant. These experiments could not show any cytotoxic effect on endothelial cells. In ongoing studies we measured the concentrations of adhesion molecules; markers of endothelial activation; in maternal sera; in the supernatant of cultured endothelial cells; and on cell surface after stimulation with the above mentioned sera. In the supernatant we couldn'

10666866

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[Pre-eclampsia--endothelial damage of endothelial activation?].

t determine any different concentrations of adhesion molecules after stimulation with the different sera; but using immunofluorescence-microscopy an increased concentration of those molecules could be detected on the endothelial surface after stimulation with preeclamptic sera than compared to sera from normotensive controls. In conclusion; our experiments support the hypothesis that sera from preeclamptic women may cause endothelial activation.

10666866

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[Therapy of para-articular hip fractures in the elderly].

Fractures of the hip in old patients are life-threatening events. A steady increase of that fracture type is likely in the near future. Surgical therapies and strategies have to consider the special requirements and problems of geriatric patients to achieve better results. They have to be designed together with new concepts of geriatric rehabilitation programmes.In 1992 148 patients with hip fractures were treated at the department of traumatology; University Ulm. Follow-up parameters were daily activities

10666855

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[Therapy of para-articular hip fractures in the elderly].

in life pre- and postoperatively as well as mortality; type of fracture and surgical treatment.There were 79 femur fractures of the collum and 69 fractures of the trochanteric region. Mean age was at 81.2 and 81.9 years respectively (68 f/11 m versus 52 f/13 m). At the time point of accident 84 patients lived at home whereas the remaining stayed at a nursing home. The highest mortality was found in patients living in a nursing home (93%). The overall mortality one year following the trauma was 26%. 50% of t

10666855

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[Therapy of para-articular hip fractures in the elderly].

he patients had hip prosthetic replacement; the remaining received a gliding screw; 9 patients a proximal femoral nail or lag screws (n = 6).Our results demonstrate that hip fractures in geriatric patients have a high mortality; especially in those living in a nursing home. The surgical concepts should aim to reduce that number and to allow the same daily activity of life as preoperatively. The main part in these concepts is an early start of geriatric rehabilitation. There are at least two groups. On the o

10666855

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[Therapy of para-articular hip fractures in the elderly].

ne hand; the active old patient who acquires his fracture during an activity. In this cases the aim must be the full rehabilitation and afterwards returning to normal environment. On the other hand there are the patients living in a nursing home who have the highest risk of injury related death. In these patients the first aim must be prevention of the accident.

10666855

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[Thrombocyte activation in pre-eclampsia].

nan

10666867

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[Functional and socioeconomic outcome of inpatient rehabilitation of patients with complex hand injuries].

Evaluation of functional outcome and socio-economic results of patients with complex hand injuries after inpatient rehabilitation.In a prospective investigation 36 patients with complex hand injuries received an intensive therapy regime under inpatient conditions. In all patients functional parameters of the hand (total active range of motion; palm to palm distance; spread between thumb and index finger; spread between thumb and little finger) and the score of Buck-Gramcko were registered initially and at t

10666860

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[Functional and socioeconomic outcome of inpatient rehabilitation of patients with complex hand injuries].

he end of inpatient rehabilitation. Socio-economic data (kind of discharge; job reintegration; further treatment) were documented as well.The total active range of motion could be improved from 36% to 69%; spread D1-D5 from 18.5 to 20.7 cm and spread D1-D2 from 13.9 to 15.6 cm. The palp to palm distance of all fingers was reduced from 4.6 cm to 2.3 cm. The Buck-Gramcko score of all injured fingers improved from 4.2 points (poor) at admission; to 11.8 points (good) at discharge; At the end of inpatient rehab

10666860

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[Functional and socioeconomic outcome of inpatient rehabilitation of patients with complex hand injuries].

ilitation 18 patients could return to their job either gradually or on full-time.Even patients with complex hand injuries; good functional results could be achieved by an intensive inpatient rehabilitation characterised by close medical supervision and guidance and tight clinical controls.

10666860

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[Early diagnosis of isthmic spondylolysis with MRI].

Early diagnosis of isthmic lumbar spondylolysis cannot always be established on plain radiographs and CT scans; only. In the case presented here; magnetic resonance imaging (MRI) showed typical bone marrow changes in T1- and T2-weighted images; even at an early stage.A 11-year old female judoka complained of deep lumbar pain with local tenderness to pressure at L3 to S1. Clinically; there was no neurologic deficit. Conventional x-ray showed no abnormalities. In contrast; MRI revealed a locally ill-defined b

10666858

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[Early diagnosis of isthmic spondylolysis with MRI].

one marrow oedema in both pars interarticularis of the 5th lumbar vertebra. This was interpreted as the typical MR-tomographic feature of occult stress fracture; which has to be seen as early evidence of isthmic spondylolysis. Complete restitution was achieved after conservative treatment.In early spondylolysis--presented here in form of a case report--; changes of MR signal intensity in the pars interarticularis may be detected; even before fracture lines are to be seen on plain radiographs. Further studie

10666858

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[Early diagnosis of isthmic spondylolysis with MRI].

s are necessary to confirm MRI to be the method of choice for early diagnosis.

10666858

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[Trophoblast invasion in pre-eclampsia].

It is generally accepted that insufficient invasion of trophoblast cells into the myometrial portions of the spiral arteries is thought to play a crucial role in the development of preeclampsia. As a consequence; uteroplacental vessels fail to undergo adaptive changes which are imperative to provide a sufficient blood supply to the placenta. Consecutive placental hypoxia is supposed to cause secretion/shedding of still unidentified placental metabolites resulting in different forms of pregnancy-induced hype

10666868

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[Trophoblast invasion in pre-eclampsia].

rtension. This review presents published data concerning the causes of insufficient trophoblast invasion in preeclampsia. Expression of HLA-G by extravillous trophoblast cells seems to be altered; resulting in activation of the maternal immune system. The pattern of integrin expression as well as the secretion of proteases is reported to be disturbed; which could lead to a reduced invasive potential of the trophoblast cells. Recent data indicate a pathophysiological role of NK-cells and macrophages in the a

10666868

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[Trophoblast invasion in pre-eclampsia].

ltered trophoblast invasion. Also angiotensinogen Thr235 polymorphism seems to alter early physiologic changes in spiral arteries. In summary; preeclampsia seems to be induced by a multifactorial disturbance of trophoblast invasiveness which is characterized by reduced invasiveness of the trophoblast cells themselves and by an activated maternal immune response blocking the invasion by the semiallogenic trophoblast.

10666868

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[Hallux valgus: a therapy concept and its outcome from 1993 to 1996].

Aim of this study is to present the treatment concept and the results of hallux valgus surgery of our department.The criteria for decision making are 1st intermetatarsal angle; congruency of the first metatarsophalangeal joint and sesamoid position. According to our concept we performed between 1993 and 1996 42 Chevron osteotomies for mild; 138 Chevron with lateral soft tissue release (Chevron + LSR) for moderate and 93 basal crescentic (Mann) osteotomies with lateral soft tissue release for severe hallux v

10666861

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[Hallux valgus: a therapy concept and its outcome from 1993 to 1996].

algus deformities.31 Chevron; 118 Chevron with lateral soft tissue release and 80 basal crescentic osteotomies (Mann) were seen at an average follow up of 19 months (12-29) after a Chevron; respectively. 16 months (12-43) after Chevron with lateral soft tissue release and 18 months (12-32) after a basal crescentic osteotomy. 83% of all patients classified the results of the surgery as "very satisfactory" and "satisfactory". The average hallux valgus angle was corrected from preoperatively. 25.3 degrees (Che

10666861

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[Hallux valgus: a therapy concept and its outcome from 1993 to 1996].

vron); 29.9 degrees (Chevron + LSR) and 41.8 degrees (Mann) to 16.5 degrees (Chevron); 12.1 degrees (Chevron + LSR) and 14.1 degrees (Mann) at final follow up; the average first intermetatarsal angle was corrected from preoperatively 12.1 degrees (Chevron); 14.0 degrees (Chevron + LSR) and 17.4 degrees (Mann) to 7.9 degrees (Chevron); 5.8 degrees (Chevron + LSR) and 7.8 degrees (Mann) at final follow up.Our analysis of the three osteotomies revealed that with this differentiated concept we were able to achi

10666861

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[Hallux valgus: a therapy concept and its outcome from 1993 to 1996].

eve excellent and good results in more than 80% of our patients. Only with a treatment plan that includes different procedures to address the various stages of hallux valgus can one achieve the optimum result for the patient.

10666861

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[Guillain-Barré syndrome as differential diagnosis of intervertebral disk-induced nerve root compression].

Diagnosis of Guillian-Barré Syndrome usually is not difficult; but diagnostic failure occurs for the variable initial presentation. Diagnosis is based on physical examination showing loss of motor strength in more than one limb and loss of deep tendon reflexes. Ventilatory assistance; pharmacologic maintenance of cardiovascular homeostasis; corticosteroids; IgG and plasma exchange are the dominant therapeutic measures.This article reports on a case of a 59-year old surgeon suffering from degenerative disc d

10666857

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[Guillain-Barré syndrome as differential diagnosis of intervertebral disk-induced nerve root compression].

isease in the lumbar spine. The patient developed a severe course of the Guillian-Barré Syndrome with persisting motor weakness of the legs.If the primary problem at presentation is limb and back pain the pathology appears to be in the musculoskeletal rather than in neurological system. The awareness of this presentation of Guillian-Barré-Syndrome will eliminate delay in diagnosis.

10666857

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[Animal experiment models of hypertension in pregnancy--an alternative to clinical studies?].

Because of ethical constraints upon research during human pregnancy and of the heterogeneity of preeclampsia a number of experimental animal models were used to study pathophysiology of preeclampsia. We reduced the uteroplacental flow by aortic clip technique in 72 SHR-rats in 4 groups (G 1 not gravid--no clip; G 2 not gravid--aortic clip; G 3 gravid--no clip; G 4 gravid--aortic clip). While gravidity normalised blood pressure in SHR (G 3); reduction of the uteroplacental flow significantly increased matern

10666869

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[Animal experiment models of hypertension in pregnancy--an alternative to clinical studies?].

al blood pressure (G1 240/180 mmHG; G2 238/183 mmHg; G3 148/99 mmHG; G4 200/145 mmHg) and leads to significant higher hematocrit; significant lower plasma renin activity and aldosterone plasma concentration; as it is found in human superimposed preeclampsia. SDS-page electrophoresis proved a significant increase of urinary high density proteins.In comparison to chronical inhibition of NO-synthesis or chronical application of ultra-low-doses-endotoxin; reduction of uterine flow by aortic compression is a rel

10666869

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[Animal experiment models of hypertension in pregnancy--an alternative to clinical studies?].

iable animal model and leads in SHR to a superimposed preeclampsia-like syndrome with many similarities to human clinical findings. Animal models for preeclampsia are no alternative to clinical studies; but they are furthering our understanding of pathophysiology in many fields.

10666869

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[Osteogenesis in exposure to ionizing radiation in vitro].

Irradiation is a well established therapeutical concept to prevent heterotopic ossification after joint replacement. The influence of irradiation on proliferation of mature osteoblasts and their potential osteoprogenitors; matrix formation and mineralization are not well known in this setting. We therefore studied the effect of different doses of ionizing irradiation on the several steps of osteogenesis in vitro; using cells isolated from the juvenile rat. A colony forming test; the MTT-viability assay; a c

10666862

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[Osteogenesis in exposure to ionizing radiation in vitro].

ell count; measurement of the cellular protein content and alkaline phosphatase activity; as well as determination of in vitro mineralisation have been applied to calvarian osteoblasts; fibroblasts and stromal bone marrow cells. Irradiation results in a dose-dependent suppression of clonogenic activity in all mitotically active cells; but metabolic activity and matrix synthesis were not impaired. In dense cultures alkaline phosphatase expression and in vitro mineralisation were not significantly affected by

10666862

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[Osteogenesis in exposure to ionizing radiation in vitro].

irradiation. Our experimental in vitro data suggest that irradiation inhibits the initial phase of in vivo osteogenesis due to the cytostatic effect. Postoperative irradiation after THR must therefore take place as early as possible. The homoeostasis of normal; orthotopic bone does not seem to be severely affected by local low-dose irradiation.

10666862

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[Heparin-induced thrombocytopenia after elective hip joint replacement with postoperative prevention of thromboembolism with low-molecular-weight heparin].

Heparin-induced thrombocytopenia (HIT) is a severe side effect of the prophylaxis of venous thromboembolism with unfractionated heparin. The aim of the present study is to gain more information on the incidence of HIT during prophylaxis of venous thromboembolism with low-molecular-weight heparin in elective hip surgery.586 consecutive patients were included into the prospective study; who were admitted to hospital for elective hip replacement. The incidence of thrombocytopenia; clinically manifest venous th

10666863

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[Heparin-induced thrombocytopenia after elective hip joint replacement with postoperative prevention of thromboembolism with low-molecular-weight heparin].

romboembolism and of the heparin-induced IgG antibodies were analysed during prophylaxis with low molecular-weight heparin. Patients received once daily subcutaneously low molecular-weight heparin for a mean of 28 days postoperatively. Platelet counts and clinical examinations for the presence of venous thromboembolism were done at days 0; 2; 7 (+/- 1) and 12 (+/- 2). Heparin-induced IgG antibodies were determined before and after a 12 (+/- 2) days prophylaxis with low molecular-weight heparin in 265 of 586

10666863

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[Heparin-induced thrombocytopenia after elective hip joint replacement with postoperative prevention of thromboembolism with low-molecular-weight heparin].

patients randomly. Patients were reexamined for thromboembolic complications after 3 and 6 months. The clinical suspicion of thromboembolic complication was documented objectively.None of the patients developed a decrease of platelets of < 50% of the initial value. Ten of 265 patients had elevated IgG antibodies against heparin/platelet factor 4 before prophylaxis (3.8%). After the 12 (+/- 2) days prophylaxis 13 of 265 patients had elevated IgG antibodies (4.9%). C14 serotonin assay was positive in 0 of 10

10666863

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[Heparin-induced thrombocytopenia after elective hip joint replacement with postoperative prevention of thromboembolism with low-molecular-weight heparin].

patients before treatment and in 3 of 19 patients at day 12 (+/- 2). Ten patients developed venous thromboembolism postoperatively (8 x deep venous thrombosis; 2 x pulmonary embolism; no fatal embolism). Only 1/19 patients with elevated antiheparin IgG titres developed venous thromboembolism. The C14 serotonin assay was negative in this patient. Two patients died in the postoperative phase due to underlying cardiovascular diseases.In patients with elective hip replacement prophylaxis of venous thromboembol

10666863

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[Heparin-induced thrombocytopenia after elective hip joint replacement with postoperative prevention of thromboembolism with low-molecular-weight heparin].

ism with low molecular-weight heparin was associated with a very low incidence of HIT; and hence screening for HIT antibodies is not required.

10666863

[ null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null ]

[Significance of the renin-angiotensin-aldosterone system for pathogenesis and early diagnosis of pregnancy-induced hypertension with special reference to mineralocorticoid receptors].

In women with pregnancy-induced hypertension (PIH) the density of mineralocorticoid receptors (MR) in human mononuclear leukocytes (HML) is reduced compared with healthy pregnant women. The same applies to plasma levels of aldosterone and 18-hydroxycorticosterone. In this study; we investigated whether alterations of these parameters preceded the development of clinical symptoms and; therefore; might be potential predictors of PIH involved in the pathogenesis.In eighty-four women belonging to the risk-group

10666870

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[Significance of the renin-angiotensin-aldosterone system for pathogenesis and early diagnosis of pregnancy-induced hypertension with special reference to mineralocorticoid receptors].

for PIH but not showing any symptoms neither of PIH nor preeclampsia (PE) we characterized prospectively before the onset of disease in the second trimester of pregnancy mineralocorticoid receptor status in HML and steroid plasma levels of aldosterone and its precursors as well as cortisol through radioimmunoassay.15 women developed PIH; three of which developed PE. Neither in the density of MR nor in the affinity the women that developed PIH showed any difference from healthy women. Steroid plasma levels

10666870

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[Significance of the renin-angiotensin-aldosterone system for pathogenesis and early diagnosis of pregnancy-induced hypertension with special reference to mineralocorticoid receptors].

were identical as well.We conclude that a reduction of mineralocorticoid receptors does not precede PIH within the peripheral blood. But still one can assume that the RAAS may be involved in the pathogenesis of PIH; possibly on a local level within the placenta or as a secondary change; initiated by still unknown factors.

10666870

[ null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null, null ]

[The autonomic nervous system and pre-eclampsia].

Alterations in the autonomic cardiovascular control have been implicated to play an important etiologic role in preeclampsia. Earlier assessments of sympathetic nervous system activity by measurements of urinary and plasma levels of catecholamines showed contradictory results; due to serious methodological problems. The microneurographic technique enables the assessment of sympathetic outflow to the vascular bed of skeletal muscles. By the use of this technique it has been shown that preeclampsia represents

10666871

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[The autonomic nervous system and pre-eclampsia].

a state of sympathetic overactivity as compared to healthy pregnant women. Other studies have shown that exogenous stimulation of the celiac ganglion causes a HELLP-syndrome-like disease in pregnant rats and that preeclamptic human plasma increases norepinephrine release in isolated sympathetic neurons of chicken embryos. These data suggest that the autonomic nervous system may play a fundamental role in the etiology of preeclampsia.

10666871

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[Hypertensive illnesses in pregnancy: when is ambulatory management possible, when is hospitalization indicated?].

Hypertensive disorders complicating pregnancy are the most common medical complications of pregnancy and are a major cause of maternal and perinatal morbidity and mortality. Thorough ambulatory obstetric care is likely to achieve a risk reduction. The main topics of ambulatory obstetric care are early identification of typical signs of preeclampsia; detection of uteroplacental insufficiency; and their consequences; detailed information of the patient; and early admission to a specialised obstetric care unit

10666872

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[Hypertensive illnesses in pregnancy: when is ambulatory management possible, when is hospitalization indicated?].

or perinatal center. Early diagnosis; close medical supervision; and timely delivery are the keys of the treatment of preeclampsia.

10666872

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[Doppler ultrasound findings in therapy with urapidil].

In a prospective study we investigated; whether changes in fetal or maternal circulation can be found by Doppler sonography under therapy with urapidil.We investigated in 11 patients with severe pregnancy-induced hypertension (PIH) or superimposed preeclampsia in the third trimester. Doppler flow results of maternal and fetal vessels before and during therapy with urapidil. Hemodynamic parameters; like maternal blood pressure; and heart rate as well as other clinical parameters were assessed.Whereas the ant

10666873

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[Doppler ultrasound findings in therapy with urapidil].

ihypertensive effects in the systolic and diastolic blood pressure were significant; we couldn't find changes in the resistance indices of fetal circulation. In contrast we found a decrease in the resistance indices in maternal vessels after an average of six days of urapidil therapy. These changes were significant in the uterine artery on the side of placental insertion.Because of only few side effects and a safe lowering of blood pressure; therapy with urapidil seems preferable to other well known drugs.

10666873

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[Doppler ultrasound findings in therapy with urapidil].

Although Doppler flow velocimetry of uteroplacental vessels has no diagnostic benefit in monitoring PIH; the findings with this method under prolonged antihypertensive therapy are a chance for a better understanding of hemodynamic changes. The decrease in the resistance indices is another argument for the use of urapidil.

10666873

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[Early detection of pre-eclampsia within the scope of prenatal care].

Pregnancy-induced hypertension and preeclampsia account for about 25% of perinatal morbidity and mortality and are a leading cause of maternal death in developed countries. Consequently; early diagnosis of the disease seems very important. Numerous clinical and biochemical methods have been described and tested for the prediction of preeclampsia. The results of these studies are critically described here. In summary; no test presently available serve as a reliable early marker of developing preeclampsia. Ho

10666874

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[Early detection of pre-eclampsia within the scope of prenatal care].

wever; vaginal Dopplerultrasound may allow prediction as early as the 12th to 16th week of gestation. Moreover; methods detecting underlying mechanisms of the disease such as endothelial dysfunction and platelet activation; are being developed and might provide improved early identification of pregnant women at high risk.

10666874

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[The role of antiphospholipid antibodies in patients with pre-eclampsia].

nan

10666875

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[Pre-eclampsia and anesthesia].

The management of anaesthesia in patients suffering preeclampsia has to be selected individually. There is a high rate of caesarean sections in patients with preeclampsia. Intubation anaesthesia or regional anaesthesia are commonly used methods and can be considered comparable and equally useful. In our opinion; the application of regional anaesthesia should be preferred; if the initial criteria; such as normal neurologic status and blood coagulation; are fulfilled. We believe in a considerable reduction of

10666876

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[Pre-eclampsia and anesthesia].

vital risks when using regional anaesthesia. Our aim was to figure out the risk-factors of preeclampsia and preterm maturity regarding anaesthesia management. Preeclampsia is a severe illness in pregnancy with a frequency of 5-10%. In 1997; we experienced 73 patients with praeeclampsia according to the definition of ISSPH. Mode of delivery was conventional in 10 patients; 2 patients had a vacuum extraction and 61 patients needed a caesarean section. The rate of epidural anesthesia for delivery was 51%. We

10666876

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[Pre-eclampsia and anesthesia].

used epidural anaesthesia in 6 spontaneous deliveries; in 2 vacuum extractions and in 30 caesarean sections. There were no problems with epidural anaesthesia and the outcome of mother and child was also considered to be excellent. We suggest to use regional anesthesia techniques whenever possible.

10666876

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[Current aspects of antihypertensive therapy in pregnant patients with pre-eclampsia].

Preeclampsia is a disease which occurs in Europe in about 6-8%; in the USA in about 7-10% and in Africa in about 18% of all pregnancies. A causal treatment of preeclampsia is; with the exception of delivery; not possible up to now. Since a prematurely delivery of the newborn has to be avoided because of the risks caused by immaturity of lungs; treatment and care of pregnant women having preeclampsia or any other kind of hypertensive diseases is restricted to the following approaches: antihypertensive treatm

10666877

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[Current aspects of antihypertensive therapy in pregnant patients with pre-eclampsia].

ent; volume expansion; and eclampsia prophylaxis with magnesium sulfate. Object of this treatment is to avoid complications on the mother's side caused by the disease and to postpone delivery; as far as possible from the child's side; in order to reduce the consequences of premature birth. During antihypertensive treatment of patients with serious hypertension; i.e. with diastolic blood pressure of 110 x mm Hg and higher; dihydralazine is in clinical use since 40 years; although many patients suffer from si

10666877

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[Current aspects of antihypertensive therapy in pregnant patients with pre-eclampsia].

de-effects of dihydralazine such as distinctive tachycardia; headaches; fluid retention and nausea. With urapidil a well controllable antihypertensive is available; which prevents the effect of catecholamines at the vascular wall by a postsynaptic alpha-1 receptor blockade. Previous studies related to the application of urapidil in the treatment of hypertension during pregnancy certify the good controllability of urapidil following intravenous application as well as minor side-effects after start of treatme

10666877

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[Current aspects of antihypertensive therapy in pregnant patients with pre-eclampsia].

nt.

10666877

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[Epidemiology, risk factors and predictors of pre-eclampsia].

nan

10666878

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[Mannerfelt arthrodesis of the wrist joint in patients with chronic polyarthritis. A retrospective analysis of 24 cases].

Mannerfelt established his technique of wrist arthrodesis with stabilisation by an intraosseous rushpin as a secure method for patients with rheumatoid arthritis. This study was performed to evaluate the mid-term results in a consecutive group of patients.Out of a group of 39 operations 24 wrist arthrodeses (61%) in 19 patients have been followed 12-96 months postoperatively (average 44 mths) by clinical testing and radiographic examination. All operations were performed in the original technique. All patie

10666859

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[Mannerfelt arthrodesis of the wrist joint in patients with chronic polyarthritis. A retrospective analysis of 24 cases].

nts suffered from rheumatoid arthritis in an advanced stage (Larsen III-V).All but one patient were free of pain. Function and strength of the hand increased significantly in all patients. All patients had additional resection of the ulnar head that led to normal pro-supination of the forearm. 18 patients were very satisfied with the result of the procedure. All but one of the wrists showed complete fusion. In one case there was an intraoperative perforation of the pin through the radial cortex; in another

10666859

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[Mannerfelt arthrodesis of the wrist joint in patients with chronic polyarthritis. A retrospective analysis of 24 cases].

case we saw a fissure of the shaft of the third metacarpal bone. One patient showed a dysesthesia in the third finger.The results in this group of patients confirmed the advantages of Mannerfelt's technique such as simple operative technique; high fusion rate and low incidence of complications.

10666859

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[Psychiatry in XXI century].

nan

10666879

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[Cerebral strokes at young age].

791 patients aged 15-44 years with different forms of cerebral stroke that accounted for 9.4% from all the patients hospitalized because of stroke were treated. Ischemic stroke (IS) was diagnosed in 477 patients (60.3%); hemorrhagic stroke (HS) in 293 patients (37.3%); thromboses of the sinuses and veins of the brain in 19 patients (2.4%). IS to HS was 1.6:1; cerebral strokes were observed in men twice as frequently as in women. The main causes of HS (180 men; 115 women) were anomalies of cerebral vessels a

10666880

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[Cerebral strokes at young age].

nd arterial hypertension. Intracerebral and subarachnoidal hemorrhage occured with the same frequency. 38% of the patients died. The main causes of IS in 477 patients (285 men; 192 women) were arterial hypertension; rheumatism and atherosclerosis of cerebral and precerebral arteries. Embolic strokes occurred 4;5 times more frequently in women; than in men. 6.7% of the patients died. Among the patients with disorders of venous cerebral circulation (13 women; 6 men) 2 women with thrombosis of upper longitidin

10666880

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[Cerebral strokes at young age].

al sinus died. According to authors' data pregnancy and delivery are a significant risk factor for development of all forms of cerebral stroke.

10666880

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[Collagen type VI content in healthy and arthritis knee joint cartilage].

Since collagen type VI seems to play an important role in cartilage metabolism and is increased in osteoarthritis; the aim of this study was to investigate whether different stages of osteoarthritis can be characterised by the content of collagen type VI in human knee cartilage.Collagen type VI was investigated in 148 histologically normal and 117 osteoarthritic cartilage samples from 18 different localisations of human knee joints. It was quantified in cartilage extracts using an inhibition-ELISA.In normal

10666864

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[Collagen type VI content in healthy and arthritis knee joint cartilage].

cartilage the average content of collagen type VI was 0.48 per cent of total collagens. Interestingly; there was a high variability not only in osteoarthritic; but also in normal cartilage. The statistical analysis showed significant differences between normal femoral; tibial or retropatellar cartilage samples. Therefore; normal and osteoarthritic samples from different localizations had to be compared separately. A significant increase of collagen type VI was already found in early osteoarthritic lesions.

10666864

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[Collagen type VI content in healthy and arthritis knee joint cartilage].

Inspite of a statistically significant increase of collagen type VI in osteoarthritic cartilage; the range of concentrations found in normal and osteoarthritic samples overlap. In view of the high interindividual variability; collagen type VI is not very precise in the diagnosis of early osteoarthritic lesions if used as the only marker.

10666864

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[Dreams and psychologic defence in children and juveniles with neurotic disorders].

The examination of 78 patients at different stages of neurotic disorders and 25 healthy individuals (10-17 years old) has shown that the dynamics of dreams at compensatory stage was directed to their intensification; affective and cognitive activation and to reduction of dreams' activity during decompensation of neurotic disorders. This may indicate their role in psychologic defence. In neurotic patients peculiarity of the reaction to stress was the presence of some latent period after stress; that preceded

10666881

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[Dreams and psychologic defence in children and juveniles with neurotic disorders].

the very reaction of dream to stress; its longer duration than in healthy individuals and its qualitative peculiarity. That may reflect complexity of adaptation to stress influence in neurotic patients.

10666881

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[Clinical features of ischemic heart disease and modes of subjective perception of illness].

The sample included 91 inpatients with different clinical forms of ischemic heart disease (IHD) and modes of subjective perception of illness (subjective meaning of illness). Prichard's Reaction to Illness Questionnaire; Hospital Anxiety and Depressive Scale; Rotter's Internal-External Control Scale and Illness Locus of Control Scale (Bevz I.A.;1998) were used on day 14 after admission for qualification of the patient's subjective perception of illness. The following clinical predictors of hypernosognia (in

10666882

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[Clinical features of ischemic heart disease and modes of subjective perception of illness].

adequately high subjective significance of illness) were revealed: 1) the onset of IHD in midlife (<65 years) with its subsequent fast progression including high incidence of recurrent coronary events and/or congestive heart failure; 2) "typical" and protracted angina pectoris; 3) cardiac arrhythmias accompanying persistent high heart rate (sinus tachycardia; chronic atrial fibrillation; frequent extrasystoles) and defying any self-care; and 4) severe heart failure. On the other hand clinical predictors of

10666882

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[Clinical features of ischemic heart disease and modes of subjective perception of illness].

hyponosognosia (inadequately low subjective significance of illness) included 1) the onset of IHD in elderly individuals (>65 years) and its subsequent slow progression without recurrent coronary events and/or congestive heart failure; 2) the socalled "anginal syndrome" (lack of angina's coupling with psychical exertion; atypical pain location; inconstant efficiency of nitroglycerin) and silent myocardial ischemia; 3) the paroxysmal cardiac arrhythmias (infrequent extrasystoles; paroxysmal atrial fibrillati

10666882

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[Clinical features of ischemic heart disease and modes of subjective perception of illness].

on; supraventricular tachyarrhythmias) with normal or slow heart rate between the paroxysms and high efficiency of self-care; and 4) mild to moderate heart failure. The findings are discussed in terms of prediction of specific modes of subjective perception of illness and its practical implications for correction of patient's attitude to his/her disease; correction of non-compliance; optimization of therapeutical alliance and use of heart care resources.

10666882

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[Therapy of autonomic disorders by xanax (alprazolam)].

The paper presents an open noncomparative investigation of 36 patients with different manifestations of the syndrome of autonomic dystonia. 20 patients (group 1) had permanent autonomic disorder in context of generalyzed anxious disorders; 16 patients (group 2) had panic attacks. The examination was performed before and 4 weeks after monotherapy with xanax (1.5-2.5 mg/day). Clinical-neurologic study estimated both presence and a degree of manifestations of the syndrome of autonomic dysfunction; hyperventila

10666883

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[Therapy of autonomic disorders by xanax (alprazolam)].

tory syndrome and sleep disorders. Psychologic investigation included estimation of anxiety according to Spilberg's test; depression according to Beck's scale; SCL Scale was also used. Algesic syndrome was estimated by complex algesic questionnaire. Neurophysiologic study determined a contingent negative deviation and nociceptive flexory reflex. A positive therapeutic activity of xanax was established. The highest therapeutic effect was achieved in group 1 (83%) using lower doses (1.5 mg/day). In group 2 hi

10666883

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[Therapy of autonomic disorders by xanax (alprazolam)].

gher doses were needed (2.5 mg/day). In this case the effect was achieved in 83% of the cases; but full absence of panic attacks was observed only in 25% of the patients. Predictors of the drug's efficiency appeared to be short duration of the disease; slight manifestation of depression and absence of the algesic syndrome.

10666883

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[24-h ambulatory monitoring of cardiovascular indices in patients with panic disorders].

24-h monitoring of arterial pressure (AD) and heart rate (HR) was twice performed in 14 patients with panic attacks (in exacerbation and after a course of fluoxetine for 6 weeks). Panic attacks were followed by objective increase of both AD and HR in only 1/3 of the cases and by objective HR increase in 60% of the patients. Although patients with panic attacks were normothymics; hypertensive reactions can arise in them; during sleep for the most part. Alteration of HR variability in sleep-awakening cycle wa

10666884

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[24-h ambulatory monitoring of cardiovascular indices in patients with panic disorders].

s the most paradoxical (excess HR variability in awakening state and decreased change during a sleep). These alterations of HR variability persisted after control of panic attacks with fluoxetine. This allows to consider HR variability as a factor which reflects predispositional peculiarities of autonomic system functioning in patients with panic disorders.

10666884

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0.036872752, 0.00016958026, 0.07555325, 0.018396499, 0.056784566, -0.026650997, 0.00914508, 0.036792997, -0.043359376 ]

[Neurophysiologic mechanisms of the disorders in recognition of emotions in endogenic depression].

In 46 male patients with endogenic depressions of different nosology (22 patients with affective disorder; 24 with juvenile slow-progredient schizophrenia) and 22 healthy individuals (a control group) visual evoked potentials (EPs) were registered during recognition of emotionally positive; negative or neutral facial expression. It was found that deficient recognition of emotions in depressions was determined by alteration of different stages of information analysis. In inferio-temporal and occipetal cortic

10666885

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[Neurophysiologic mechanisms of the disorders in recognition of emotions in endogenic depression].

al areas the Eps revealed delayed primary analisis of visual information and reduction of components responsible for classification stage and decision making. In anteriocentral cortical areas only late stages of analysis were altered; and they were depending on nosology of depressive sindrom. Dynamics of topographic maps revealed disturbance of analysis in the right hemisphere in patients with affective disorders and in left hemisphere in schisophrenics. In both groups of patients deficit of interhemispheri

10666885

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[Neurophysiologic mechanisms of the disorders in recognition of emotions in endogenic depression].

c transfere was found.

10666885

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[Sporadic amyotrophic lateral sclerosis associated with Asp90Ala CuZn-superoxide dismutase mutations in Russia].

16 blood samples from Russian patients (Moscow) with idiopathic motor neuron disease were analysed for mutations in the CuZn-superoxide dismutase gene. Two patients (12.5%) with amyotrophic lateral sclerosis (ALS) were found to have a disease related mutation. One patient appears to have autosomal recessive adult-onset ALS associated with homozygosity for Asp90Ala and presents the characteristic phenotype of very slowly ascending paresis with both lower and upper motor neuron signs. The other patient hetero

10666886

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[Sporadic amyotrophic lateral sclerosis associated with Asp90Ala CuZn-superoxide dismutase mutations in Russia].

zygous for Asp90Ala presents ALS with lumbar onset and rapid progression. Both of cases are apparently sporadic.

10666886

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0.007279715, -0.02526966, 0.046541553, 0.035520688, -0.0403018, 0.0015109797, -0.001230731, 0.000063309206, -0.03700634, 0.07390464 ]

[The level of middle mass molecules and lipid peroxidation in blood of patients with different forms of stroke].

To elucidate correlation between processes of lipid peroxidation (LP) and accumulation of peptides from the group of "middle molecules" (PMM) in blood; we made investigation of blood of 81 patients with ischemic and hemorrhagic stroke. Gel-filtration column chromatography for PMM separation was performed. Divided fractions were registered with UV-monitor at wave length equal to 254 nm. The character of both spontaneous and Fe(2+)-induced chemiluminescence; the level of malonic dialdehyde (MDA) and conjugate

10666887

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-0.013422207, 0.022496559, -0.04037107, -0.052069806, -0.016738588, -0.043165192, -0.04501923, -0.0046122517, -0.008780578, 0.029064039 ]

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[The level of middle mass molecules and lipid peroxidation in blood of patients with different forms of stroke].

d dienes (CD) were estimated. It was established that the level of LP processes was significantly increased in blood and erythrocytes of patients with stroke; especially in hemorrhagic form. The total content of PMM; especially of A and A4 fractions; as well as D and F fractions was almost twice as much in blood. A correlation was observed between accumulation of PMM in blood of patients with stroke and PL induction; that may be the factor of PMM generation. A conclusion was made; that accumulation of some

10666887

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[The level of middle mass molecules and lipid peroxidation in blood of patients with different forms of stroke].

PMM classes in blood of patients with strokes was related to LP processes; which were responsible for the severity of the secondary pathochemical alterations in tissues of the brain. These findings should be considered in elaboration of drug treatment and estimation of the disease prognosis.

10666887

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[Peculiarities of polymorphism in gene of serotonin transporter in men from different ethnic groups with acute alcoholic psychoses].

Analysis of polymorphism in locus of the gene of serotonin transporter (hSERT) was performed in men of Russian and Tatar nationalities with acute alcoholic psychoses by polymerase chain reaction. An absence of the differences in the distribution of the frequences of genotypes and alleles of hSERT gene was observed between populations examined; that corresponded to such values in Caucasians. An association was found between the allelic variations with 9 units of the repetitions of hSERT gene and an early ons

10666888

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[Peculiarities of polymorphism in gene of serotonin transporter in men from different ethnic groups with acute alcoholic psychoses].

et of chronic alcoholization and development of acute alcoholic psychosis. Among the men; who developed acute alcoholic psychosis at the age over 35 there were significant differences in distribution of frequences of genotype of hSERT-gene between the populations. Genetic heterogeneity of such pathology in Russians and Tatars and impact of hSERT in the development of the disease in Tatars; are suggested.

10666888

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-0.01348729, 0.022457056, -0.040292136, -0.05204292, -0.016712228, -0.043269, -0.045044675, -0.004703578, -0.008786975, 0.029063608 ]

[Factors of lonely living in old psychiatric patients].

70 lonely patients 60-83 years old were examined. Loneliness in the disintegrated first group (54 patients) resulted from the disintegrated family (the patients were early married). The loneliness in the second group was determined by the absence of their own family (16 patients). The main factors leading to loneliness were such diseases as schizophrenia and epilepsy; paranoic disorders of persecutive character directed to the nearest family; hypochondric depression; psychopathic-like disturbances; mental d

10666889

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[Factors of lonely living in old psychiatric patients].

efect; personality disorders in premorbid state. Among social-psychologic factors the following ones had a significance: underestimation of the mental disorders in patients by their relatives; conflicts in the family; the patient's negative orientation to marriage; their deep emotional interrelation with the parents in young and mature age; alcoholism of married couple and special psychopathic features of the relatives. The events relating with the old age (loss of elderly couple); separation with adult chi

10666889

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-0.049608756, 0.00081591157, 0.055866435, -0.04441621, -0.02282056, 0.009885803, -0.045587864, 0.07716917, 0.032220393 ]

[Factors of lonely living in old psychiatric patients].

ldren and parents; bad domestic living conditions were of less significance.

10666889

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[Classification of the dementias].

nan

10666890

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[Diagnosis of celiac disease].

nan

10666891

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[Rational management of acute community-acquired pneumonia].

nan

10666892

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