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Modulation of nociceptive transmission by NMDA/glycine site receptor in the ventroposterolateral nucleus of the thalamus. | rons in the ventroposterolateral (VPL) nucleus of the thalamus was recorded in response to pressure stimuli to the contralateral hindpaw. Intravenous injection (iv) of the glycine antagonist had no effect on these cells in normal rats. When tested in rats with CCI induced 2-3 weeks previously; however; GV196771A (0.125; 0.5 and 2.0mg/kg) blocked responses to noxious stimulation in a dose-dependent and reversible manner. Morphine (0.5mg/kg; iv) and the NMDA channel blocker MK801 (0.1mg/kg; iv) suppressed nox | 10666526 | [
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Modulation of nociceptive transmission by NMDA/glycine site receptor in the ventroposterolateral nucleus of the thalamus. | ious stimulus-evoked activity of VPL neurons in both normal and CCI-treated rats. MK801 also decreased the responses of non-nociceptive neurons to brush stimulation in both sets of animals; in contrast to the glycine antagonist which did not alter the responses of these cells. Similar results were obtained from a series of behavior experiments in which the latency for paw withdrawal from heat stimulation was measured in normal and CCI-treated rats. GV196771A (3 and 10mg/kg) injected orally; reduced the hype | 10666526 | [
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Modulation of nociceptive transmission by NMDA/glycine site receptor in the ventroposterolateral nucleus of the thalamus. | ralgesic response in the treated rats but did not change the withdrawal latency in normal rats. Taken together; these findings suggest that block of the NMDA receptor decreases nociceptive transmission in the thalamus and can modulate hyperalgesic states. GV196771A and glycine antagonists in general may represent innovative and safe agents for the treatment of neuropathic pain. | 10666526 | [
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Factors associated with anxiety and depression in facial arthromyalgia. | Facial arthromyalgia (temporomandibular joint pain dysfunction syndrome; TMD) is a chronic pain condition of unknown origin. This paper examines the extent to which the condition is associated with symptoms of anxiety and depression. It also identifies factors which may be predictive of raised levels of these two moods and of the presence of clinical anxiety and clinical depression. Self-report measures of pain beliefs; coping strategies; pain intensity; disability and mood were administered to a sample of | 10666527 | [
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Factors associated with anxiety and depression in facial arthromyalgia. | 80 facial arthromyalgia patients of differing chronicity. The results showed anxious mood to be associated with several factors including beliefs that pain is itself worsened by negative mood; passive coping in terms of catastrophising about pain; and speech problems. Depressed mood was associated with catastrophising and disability in the form of disturbance in taste and digestion. These factors may be considered as potential targets for therapy; rather than the orthodox objective of pain relief. | 10666527 | [
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Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat. | A unilateral chronic constriction injury (CCI) of the sciatic nerve produced bilateral effects in both pain related behaviors and in the pattern of forebrain activation. All CCI animals exhibited spontaneous pain-related behaviors as well as bilateral hyperalgesia and allodynia after CCI. Further; we identified changes in baseline (unstimulated) forebrain activation patterns 2 weeks following CCI by measuring regional cerebral blood flow (rCBF). Compared to controls; CCI consistently produced detectable; we | 10666528 | [
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Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat. | ll-localized and typically bilateral increases in rCBF within multiple forebrain structures in unstimulated animals. For example; the hindlimb region of somatosensory cortex was significantly activated (22%) as well as multiple thalamc nuclei; including the ventral medial (8%); ventral posterior lateral (10%) and the posterior (9%) nuclear groups. In addition; several forebrain regions considered to be part of the limbic system showed pain-induced changes in rCBF; including the anterior dorsal nucleus of th | 10666528 | [
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Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat. | e thalamus (23%); cingulate cortex (18%); retrosplenial cortex (30%); habenular complex (53%); interpeduncular nucleus (45%) and the paraventricular nucleus of the hypothalamus (30%). Our results suggest that bilateral somatosensory and limbic forebrain structures participate in the neural mechanisms of prolonged persistent pain produced by a unilateral injury. | 10666528 | [
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Validity of the pain anxiety symptoms scale (PASS): prediction of physical capacity variables. | Anxious responses to pain may lead to avoidance of behavior expected to produce pain. McCracken et al. (1992) developed the Pain Anxiety Symptoms Scale (PASS) to assess anxiety related specifically to pain. Efforts to validate the scale; however; have been confined mostly to examining associations between the PASS and other self-report instruments. This study tested whether PASS scores were related to behavioral performance variables recorded by therapists during a physical capacity evaluation. Participants | 10666529 | [
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Validity of the pain anxiety symptoms scale (PASS): prediction of physical capacity variables. | were 98 male patients with persistent pain referred to two industrial rehabilitation centers. PASS scores were correlated negatively with amount of weight lifted and carried; and results of hierarchical regressions showed that PASS scores accounted for additional variance in these variables when measures of trait anxiety; depression and pain severity were controlled. However; we did not replicate the findings of McCracken et al. (1992) that PASS scores accounted for variance in self-reported disability wit | 10666529 | [
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Validity of the pain anxiety symptoms scale (PASS): prediction of physical capacity variables. | h trait anxiety; depression or pain severity controlled. Results extend the validity of the PASS and are consistent with models of fear of pain: patients with high PASS scores may avoid potentially painful physical exertion to reduce their fear. | 10666529 | [
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Characteristics of ectopic discharges in a rat neuropathic pain model. | Injured afferent neurons produce spontaneous activity that is generated away from the normal impulse generation site. Since this activity; referred to as ectopic discharges; may play a significant role in neuropathic pain; it is important to systematically analyze the activity in various pain states. The present study used the segmental spinal nerve injury model of neuropathic pain to quantify the ectopic discharges from injured afferents in the neuropathic rat under various conditions. All aspects of measu | 10666530 | [
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Characteristics of ectopic discharges in a rat neuropathic pain model. | red ectopic discharges declined as postoperative time lengthened. Neuropathic pain behaviors declined in a similar fashion over the same time period. Surgical sympathectomy on neuropathic animals lowered the level of ectopic discharges along with neuropathic pain behaviors. The data indicate that the level of ectopic discharges is well correlated with that of pain behaviors in a rat neuropathic pain model; and this reinforces the supposition that ectopic discharges are important to the maintenance of neurop | 10666530 | [
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Characteristics of ectopic discharges in a rat neuropathic pain model. | athic pain behaviors. The data suggest that there are two components of ectopic discharge generator mechanisms: sympathetically dependent and sympathetically independent components. | 10666530 | [
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Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats. | Hindpaw injection of dilute formalin produces brief (Phase 1) and persistent (Phase 2) nociceptive responses in the rat. We recently showed that systemically-administered remifentanil during Phase 1 interacted with peripheral opioid receptors to delay the onset and termination of Phase 2 (Taylor et al.; 1997b). To test the hypothesis that opioid inhibition of proinflammatory events during Phase 1 contributed to this delay; we evaluated the effects of remifentanil on the time course of formalin-induced infla | 10666531 | [
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Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats. | mmation. We found that formalin increased paw thickness (edema); plasma extravasation and local blood flow within minutes of its injection; i.e. during Phase 1. Each of these responses was blocked during remifentanil administration (30 microg/kg i.v. bolus; followed 90 s later with a 15 microg/kg/min infusion for 13.5 min); indicating that opioids inhibit Phase 1 inflammation. Opioid blockade of the blood flow response could be reversed with a peripherally-acting opioid antagonist; naloxone methiodide; indi | 10666531 | [
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Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats. | cating that remifentanil acted upon peripheral opioid receptors. Although the administration of remifentanil during Phase 1 did not reduce the magnitude of inflammatory responses during Phase 2; it did delay the onset and termination of edema during Phase 2. As this corresponds to the effects of remifentanil on nociceptive responses during Phase 2; we suggest that opioid analgesics act upon peripheral sites to inhibit inflammation during Phase 1; leading to a delay in the temporal profile of inflammatory (a | 10666531 | [
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. | Ziconotide is a selective; potent and reversible blocker of neuronal N-type voltage-sensitive calcium channels (VSCCs). Morphine is an agonist of mu-opioid receptors and inhibits N-type VSCC channels via a G-protein coupling mechanism. Both agents are antinociceptive when they are administered intrathecally (spinally). The present study investigated the acute and chronic (7-day) interactions of intrathecally administered ziconotide and morphine on nociception in several animal models of pain. In the acute s | 10666532 | [
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. | tudy; intrathecal bolus injections of morphine and ziconotide alone produced dose-dependent inhibition of formalin-induced tonic flinch responses and withdrawal responses to paw pressure. The combination of ziconotide and morphine produced an additive inhibition of formalin-induced tonic flinch responses and a significant leftward shift of the morphine dose-response curve in the paw pressure test. After chronic (7-day) intrathecal infusion; ziconotide enhanced morphine analgesia in the formalin test. In con | 10666532 | [
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. | trast; chronic intrathecal morphine infusion produced tolerance to analgesia; but did not affect ziconotide antinociception. Antinociception produced by ziconotide alone was the same as that observed when the compound was co-administered with morphine to morphine-tolerant rats. In the hot-plate and tail immersion tests; chronic intrathecal infusion of morphine lead to rapid tolerance whereas ziconotide produced sustained analgesia with no loss of potency throughout the infusion period. Although ziconotide i | 10666532 | [
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. | n combination with morphine produced an apparent synergistic analgesic effects during the initial phase of continuous infusion; it did not prevent morphine tolerance to analgesia. These results demonstrate that (1) acute intrathecal administrations of ziconotide and morphine produce additive or synergistic analgesic effects; (2) chronic intrathecal morphine infusion results in tolerance to analgesia but does not produce cross-tolerance to ziconotide; (3) chronic intrathecal ziconotide administration produce | 10666532 | [
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. | s neither tolerance nor cross-tolerance to morphine analgesia; (4) intrathecal ziconotide does not prevent or reverse morphine tolerance. | 10666532 | [
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Sleep arousal response to experimental thermal stimulation during sleep in human subjects free of pain and sleep problems. | Although the interaction between sleep and pain is generating considerable interest (NIH Technology Assessment Panel; 1996); it is still unknown if chronic pain is the cause or effect of poor sleep. To further this understanding; subjects free of pain and sleep problems need to be studied in order to assess their response to pain during sleep; defined as a behavioral and a physiological state in which sensory processing is altered. (For example; while auditory perception remains active; other sensory inputs | 10666533 | [
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Sleep arousal response to experimental thermal stimulation during sleep in human subjects free of pain and sleep problems. | are facilitated; attenuated; or suppressed (Velluti; 199746 degrees C) was statistically greater in the lighter sleep stage 2 (48.3%) than in the deeper stages 3&4 (27.9%). A nocifensive behavioral-motor response was associated with only 2.5% of the 351 heat pain stimuli. Two other markers of sleep quality-sleep stage shift and awakening-were not influenced by the thermal stimuli. None of the subjects demonstrated any burns in the morning following the thermal stimulations applied during sleep. We conclude | 10666533 | [
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Sleep arousal response to experimental thermal stimulation during sleep in human subjects free of pain and sleep problems. | that the processing of nociceptive inputs is attenuated across sleep stages. | 10666533 | [
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Efficacy of a vibratory stimulus for the relief of HIV-associated neuropathic pain. | Pain related to HIV disease is frequently debilitating. Of the many pain syndromes that occur in persons with HIV; distal symmetrical polyneuropathy (DSPN) is particularly devastating. Because DSPN often responds; at best; only partially to available pharmacologic interventions; non-pharmacologic interventions need to be investigated. Vibration has been suggested to be effective for reducing pain in other populations with chronic pain. This randomized; sham-controlled; double-masked study tested the short-t | 10666534 | [
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Efficacy of a vibratory stimulus for the relief of HIV-associated neuropathic pain. | erm efficacy of a 45-min vibration treatment for DSPN foot pain in persons infected with HIV. Vibration therapy was delivered using a portable platform foot vibrator that provided stimulation at a frequency of 60 Hz. For all patients; the control box for the vibrator emitted an audible hum and part of the control box lit up during treatment; but only patients randomized to active treatment received vibration. Pain intensity (0-10) was measured immediately prior to and after treatment. Subjects were also que | 10666534 | [
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Efficacy of a vibratory stimulus for the relief of HIV-associated neuropathic pain. | stioned regarding pain relief (0-100%) immediately after the treatment. The mean percentage pain relief was 61.0+/-33.1% (median 70.0; range 0-100) for all patients; 67.3+/-34.0% (median 80.0; range 0-100) for vibration patients; and 55.0+/-32.0% (median 60.0; range 0-100) for sham patients. No statistically significant differences were found between the vibration and sham groups with respect to percentage pain relief (Mann-Whitney test; P=0.19) or the pre- and post-treatment current-pain difference (Mann-W | 10666534 | [
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Efficacy of a vibratory stimulus for the relief of HIV-associated neuropathic pain. | hitney test; P=0.92). These results underscore the necessity for control groups in studies of non-pharmacologic therapies for pain. | 10666534 | [
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Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia. | Irritable bowel syndrome (IBS) and fibromyalgia (FM) are considered chronic syndromes of altered visceral and somatic perception; respectively. Because there is a significant overlap of IBS and FM; shared pathophysiological mechanisms have been suggested. Although visceral perception has been well studied in IBS; somatic perception has not.To compare hypervigilance and altered sensory perception in response to somatic stimuli in patients with IBS; IBS+FM; and healthy controls.Eleven IBS females (mean age 40 | 10666535 | [
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Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia. | ); 11 IBS+FM females (mean age 46); and ten healthy female controls (mean age 39) rated pain perception in response to pressure stimuli administered to active somatic tender points; non-tender control points and the T-12 dermatome; delivered in a predictable ascending series; and delivered in an unpredictable randomized fashion (fixed stimulus).Although IBS patients had similar pain thresholds during the ascending series compared with controls; they were found to have somatic hypoalgesia with higher pain th | 10666535 | [
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Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia. | resholds and lower pain frequency and severity during fixed stimulus series compared with IBS+FM patients and controls (P<0.05). Patients with IBS+FM were more bothered by the somatic stimuli and had somatic hyperalgesia with lower pain thresholds and higher pain frequency and severity.Both hypervigilance and somatic hypoalgesia contribute to the altered somatic perception in IBS patients. Co-morbidity with FM results in somatic hyperalgesia in IBS patients. | 10666535 | [
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Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. | After mechanical injury of a peripheral nerve some axotomized afferent neurons develop spontaneous activity; which is thought to trigger abnormal pain behavior in rats and neuropathic pain in humans. Here; we analysed the ectopic activity in axotomized afferent fibers recorded from the L5 dorsal root in different time periods after L5 spinal nerve lesion and the effects of sympathectomy on it. The following results were obtained: (1) Up to 6 hours after spinal nerve transection there was almost no spontaneo | 10666536 | [
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Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. | us activity in axotomized afferents; except short-lasting injury discharges at the time of transection; (2) Three to 8 days following spinal nerve lesion; the rate of spontaneous activity was 7.3+/-7.7 imp/s (mean+/-SD; median 5.0 imp/s; n=204); 41.6% of the spontaneously active afferent neurons exhibited a bursting pattern with interspike intervals of 32.4+/-18.3 ms; (3) Twenty to 53 days after nerve lesion the rate of spontaneous activity had decreased significantly to 3.4+/-4.3 imp/s (median 2.6 imp/s; n | 10666536 | [
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Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. | =120). The frequency of bursting and non-bursting neurons remained roughly the same; (4) In sympathectomized rats; 15-45 days following spinal nerve lesion; the mean discharge rate was 3.8+/-4.3 imp/s (median 2. 3 imp/s; n=255). However; the percentage of bursting neurons and the intraburst frequency decreased significantly; (5) Spontaneous activity occurred in afferent A-fibers but not in afferent C-fibers. These results suggest that ectopic activity in axotomized afferent neurons develops within the first | 10666536 | [
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Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. | days after L5 spinal nerve lesion; decreases with time and is only marginally dependent on the sympathetic innervation. There was a positive correlation between this ectopic activity and the allodynia-like behavior in spinal nerve-lesioned rats. | 10666536 | [
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] |
Distribution and regulation of alpha(2)-adrenoceptors in rat dorsal root ganglia. | Using in situ hybridization with riboprobes the distribution of alpha(2A)-; alpha(2B)- and alpha(2C)-adrenoceptor mRNAs were studied in normal rat dorsal root ganglia and after unilateral peripheral nerve injury (total nerve transection) or inflammation. The most common adrenoceptor mRNA was of the alpha(2C) subtype (almost 80% of all neuron profiles) followed by the alpha(2A) subtype (almost 20%); whereas alpha(2B)-adrenoceptor mRNA was only found in small numbers of neuron profiles. The most dramatic effe | 10666537 | [
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Distribution and regulation of alpha(2)-adrenoceptors in rat dorsal root ganglia. | ct of peripheral nerve injury was observed for the alpha(2A)-adrenoceptor mRNA; which increased to 45% of all neuron profiles. In contrast; alpha(2C) adrenoceptor mRNA showed a small decrease in this situation. Carrageenan-induced peripheral inflammation did not affect the percentage of alpha(2A)- or alpha(2C)-adrenoceptor mRNA-positive profiles. These findings suggest that; if any of the alpha(2) adrenoceptor; the alpha(2A) subtype represents the most likely candidate in DRG neurons to be involved in sympa | 10666537 | [
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Distribution and regulation of alpha(2)-adrenoceptors in rat dorsal root ganglia. | thetically maintained pain. | 10666537 | [
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No effect of sympathetic sudomotor activity on capsaicin-evoked ongoing pain and hyperalgesia. | Complex regional pain syndromes (causalgia and RSD) can be relieved by blockade of the sympathetic efferent activity. The mechanisms of sympathetically maintained pain (SMP) are unclear. So far an adrenergic interaction between sympathetic vasoconstrictor neurons and nociceptors has been proposed. Alternatively; a cholinergic coupling of sympathetic sudomotor neurons and nociceptors is possible.To determine the effect of cutaneous sympathetic sudomotor activity on pain induced by primary afferent C-nocicept | 10666538 | [
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No effect of sympathetic sudomotor activity on capsaicin-evoked ongoing pain and hyperalgesia. | or activation with capsaicin in humans.In 10 healthy volunteers capsaicin was injected into the forearm skin to induce ongoing pain and dynamic and punctate mechanical hyperalgesia. Intensity of pain and hyperalgesia and area of hyperalgesia (planimetry) were assessed. The local skin temperature at the application and measurement sites was kept constant at 35 degrees C. In each individual the analyses were performed during the presence of low and high sympathetic sudomotor skin activity induced by whole-bod | 10666538 | [
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No effect of sympathetic sudomotor activity on capsaicin-evoked ongoing pain and hyperalgesia. | y temperature changes with a thermal suit. By altering whole-body temperature from a moderately warm to an intensely warm state; sympathetic sudomotor activity is modulated selectively in the widest range that can be achieved physiologically while sympathetic vasoconstrictor activity is continuously inhibited. The degree of sudomotor discharge was monitored by measuring cutaneous sweat production at the forearm with the colour indicator ponso-red. The inhibition of vasocontrictor discharge was monitored by | 10666538 | [
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No effect of sympathetic sudomotor activity on capsaicin-evoked ongoing pain and hyperalgesia. | measuring cutaneous blood flow at the index finger with laser Doppler flowmetry.The intensity and spatial distribution of capsaicin-evoked ongoing pain and dynamic and punctate mechanical hyperalgesia were not significantly different during the presence of high and low sympathetic sudomotor discharge.Cutaneous sympathetic sudomotor activity does not influence capsaicin induced pain and mechanical hyperalgesia. | 10666538 | [
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Effect of propranolol and granisetron on experimentally induced pain and allodynia/hyperalgesia by intramuscular injection of serotonin into the human masseter muscle. | We have previously reported that intramuscular injection of serotonin (5-HT) into the masseter muscle elicits pain and allodynia/hyperalgesia in healthy subjects. The aim of this study was to investigate whether the 5-HT(3) receptor antagonist granisetron or 5-HT(1A) receptor antagonist propranolol can reduce 5-HT induced pain and allodynia/hyperalgesia in the masseter muscle. Twenty-four healthy individuals (12 males and 12 females) without pain from the masseter muscle region participated. They were exami | 10666539 | [
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Effect of propranolol and granisetron on experimentally induced pain and allodynia/hyperalgesia by intramuscular injection of serotonin into the human masseter muscle. | ned clinically including tenderness to digital palpation (TDP) and pressure pain threshold (PPT) of the masseter muscle. 5-HT in combination with granisetron or propranolol was randomly injected on one side in a double-blind manner. 5-HT in combination with saline was used on the contralateral side. After the injections the pain intensity and PPT were recorded 10 times during 30min. After the last recording the TDP was assessed again. The injections were repeated with the other antagonist within 1 week. All | 10666539 | [
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Effect of propranolol and granisetron on experimentally induced pain and allodynia/hyperalgesia by intramuscular injection of serotonin into the human masseter muscle. | three combinations of substances elicited pain after injection; which lasted for 5-8min. 5-HT induced significantly more pain than granisetron+5-HT and propranolol+5-HT. The TDP increased significantly after injection of all combinations of substances; but there was no significant difference between them. The PPT decreased significantly after injection of 5-HT and increased significantly after injection of granisetron+5-HT; while it did not change significantly after injection of propranolol+5-HT. The diff | 10666539 | [
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Effect of propranolol and granisetron on experimentally induced pain and allodynia/hyperalgesia by intramuscular injection of serotonin into the human masseter muscle. | erence between 5-HT and granisetron+5-HT was significant. In conclusion; the results of this study indicate that injection of granisetron and propranolol into the human masseter muscle reduces pain induced by local administration of 5-HT; but that the effect of granisetron is stronger than that of propranolol. In addition; granisetron totally abolishes allodynia/hyperalgesia. | 10666539 | [
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The relation between pain beliefs, negative thoughts, and psychosocial functioning in chronic pain patients. | Cognitions and beliefs appear important in predicting adjustment to chronic pain. The current study examines how cognitions and beliefs are related to psychosocial functioning. One hundred and sixty-three chronic pain out-patients were assessed. Regression analyses were performed using scores on the Pain Beliefs and Perceptions Inventory and the Inventory of Negative Thoughts in Response to Pain as predictor variables and responses to the West Haven Yale Multidimensional Pain Inventory as criterion variable | 10666540 | [
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The relation between pain beliefs, negative thoughts, and psychosocial functioning in chronic pain patients. | s. Pain cognitions and pain beliefs were correlated. After controlling for demographics; employment status and pain severity; pain beliefs and cognitions accounted for a significant amount of the variance in general activity; pain interference; and affective distress. Negative cognitions; particularly negative self-statements; were more predictive of outcome than pain beliefs. Although these data are correlational; they provide additional support for a biopsychosocial model of adjustment to chronic pain. | 10666540 | [
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Long-term changes in sciatic-evoked A-fiber dorsal horn field potentials accompany loose ligation of the sciatic nerve in rats. | The goal of the present study was to examine whether loose ligation of the sciatic nerve was associated with long-term changes in neuronal excitability in the spinal dorsal horn in urethane-anesthetized rats. The sciatic nerve was stimulated with 0. 1 ms long pulses at 1 stimulus/5 min; and the evoked dorsal horn field potentials remained stable in the absence of tetanic stimulation. In one set of control and ligated animals; high-frequency tetanic stimulation was applied to the nerve at 50 Hz (one 400 ms t | 10666541 | [
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Long-term changes in sciatic-evoked A-fiber dorsal horn field potentials accompany loose ligation of the sciatic nerve in rats. | rain of twenty 0.1 ms pulses); and the field potentials were recorded again (1 stimulus/5 min) for up to 4 h post-tetanus. In control animals; this protocol produced significant increases in field potential amplitudes at 15; 30 and 60 min post-tetanus. Interestingly; after this time the evoked field potentials began to decrease; and attained less than 50% of their pre-tetanic values at 240 min post-tetanus. In contrast; in ligated rats the pattern of post-tetanic potentiation was significantly different as | 10666541 | [
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Long-term changes in sciatic-evoked A-fiber dorsal horn field potentials accompany loose ligation of the sciatic nerve in rats. | the increases in amplitude persisted; and at 240 min post-tetanus the field potentials were almost twice their baseline values. In another set of control and ligated animals; low-frequency tetanic stimulation was applied at 5 Hz (one 400 ms train of two 0.1 ms pulses). Again a differential pattern of post-tetanic responses between control and ligated rats was seen. In control animals; a significant decrease in amplitude was evident within 30 min; and the depression became progressively more pronounced as th | 10666541 | [
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Long-term changes in sciatic-evoked A-fiber dorsal horn field potentials accompany loose ligation of the sciatic nerve in rats. | e field potentials attained about a quarter of their baseline values at 180 min; and remained at these low levels at 240 min post-tetanus. On the other hand; in ligated animals; the depression was not significant; and at 240 min post-tetanus the field potentials were still at about 80% of their baseline values. These data demonstrate that long-term changes in spinal dorsal horn neuronal excitability accompany sciatic ligation to perhaps contribute to the development of neuropathic pain. These changes may re | 10666541 | [
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Long-term changes in sciatic-evoked A-fiber dorsal horn field potentials accompany loose ligation of the sciatic nerve in rats. | sult from a lessening of normally strong inhibitory processes in the spinal dorsal horn to generate conditions which favor post-tetanic potentiation over depression of dorsal horn neuronal responses. | 10666541 | [
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Lower limb cold exposure induces pain and prolonged small fiber dysfunction in Fabry patients. | In Fabry disease; an X-linked alpha-galactosidase A deficiency; painful crises and limb paresthesias are possibly linked to thermal exposure. Small nerve fiber function has not yet been tested after cold challenge. In two Fabry patients (15 and 17 years old); their heterozygote mother; their healthy sister; and eight controls; we determined warm and cold perception thresholds at the dorsal foot and the lower medial calf (method of limits; Somedic-Thermotest); before and 1; 5; 10 and 15 min after 30 s immers | 10666542 | [
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Lower limb cold exposure induces pain and prolonged small fiber dysfunction in Fabry patients. | ion of one leg into 5 degrees C water. Discomfort was rated from 0 to 10. At baseline; thermal thresholds of all participants were normal. In contrast to controls; the patients tolerated 30 s cold stimulation only with interruptions. The mother aborted stimulation after 6 s because of pain. The patients and their mother reported intense burning pain and numbness during and after stimulation. After cold exposure; thermal sensation was highly abnormal for 20 min in one and 80 min in the other brother. In cont | 10666542 | [
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Lower limb cold exposure induces pain and prolonged small fiber dysfunction in Fabry patients. | rols; thermal thresholds were somewhat elevated after stimulation but normalized within 10.0+/-4.6 min. Discomfort during cold exposure was rated 8-10 by the patients and their mother; but 3-5 by the healthy persons. We assume that glycolipid accumulation in cutaneous and vasa nervorum vessels as well as small nerve axons accounts for skin and small fiber malperfusion during cold induced vasoconstriction. Transitory ischemia initiated burning pain and prolonged small fiber dysfunction. | 10666542 | [
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The reliability and validity of the COMFORT scale as a postoperative pain instrument in 0 to 3-year-old infants. | The aim of this study was to test the reliability and validity of the COMFORT scale as a postoperative pain instrument for children aged 0-3 years. Subjects were 158 neonates and toddlers after major abdominal or thoracic surgery. Trained nurses rated the children's pain at 3; 6 and 9 h postoperative on the Pediatric Surgical Intensive Care Unit using the COMFORT and a VAS for pain. Interrater reliability of the COMFORT items proved to be good (Kappa 0.63-0.93) for all items with the exception of the item ' | 10666543 | [
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The reliability and validity of the COMFORT scale as a postoperative pain instrument in 0 to 3-year-old infants. | Respiratory response'; which was moderate (Kappa 0.54). LISREL analyses showed that the structure of the COMFORT data was best represented by three latent variables: COMFORT 'behaviour' with loadings from the behavioural items (Alertness; Calmness; Respiratory response/Crying; Physical movement; Muscle tone and Facial tension) and separate latent variables for 'Heart rate baseline' (HR) and 'Mean arterial blood pressure baseline' (MAP). Factor loadings of the items were invariant across time; indicating sta | 10666543 | [
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The reliability and validity of the COMFORT scale as a postoperative pain instrument in 0 to 3-year-old infants. | bility of the structure. The latent variables COMFORT 'behaviour' and VAS pain were highly interrelated indicating congruent validity. Stability of COMFORT 'behaviour' and VAS pain was moderate which might be due to varying painful episodes in this sample. HR and MAP; although stable across time; were weakly related to VAS pain and COMFORT 'behaviour'. These findings support the use of the COMFORT 'behaviour' scale to assess postoperative pain in neonates and infants. | 10666543 | [
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The prevalences of cytochrome c oxidase negative and superpositive fibres and ragged-red fibres in the trapezius muscle of female cleaners with and without myalgia and of female healthy controls. | The association of cytochrome c oxidase negative fibres (COX-negative) and ragged-red fibres (RR-fibres) with work related trapezius myalgia has been proposed. Hitherto studies have been small or without control groups. The aim of the present study was to investigate the prevalences of RR-fibres and COX-negative fibres in female cleaners with (n=25) and without (n=23) trapezius myalgia and in clinically healthy female teachers (n=21). The cleaners did mainly floor cleaning requiring monotonous loading on th | 10666544 | [
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The prevalences of cytochrome c oxidase negative and superpositive fibres and ragged-red fibres in the trapezius muscle of female cleaners with and without myalgia and of female healthy controls. | e trapezius muscle. A questionnaire covering background data and aspects of pain (prevalence; duration; intensity and influence on daily living) was answered. Biopsies were obtained from the trapezius muscle by an open surgical technique. The three groups did not differ in prevalence of COX-negative or COX-superpositive (i.e. type-I fibres with extremely strong brownish reaction in both the COX and SDH/COX stainings) fibres. The prevalence of COX-negative fibres was age dependent. Two subgroups of RR-fibres | 10666544 | [
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The prevalences of cytochrome c oxidase negative and superpositive fibres and ragged-red fibres in the trapezius muscle of female cleaners with and without myalgia and of female healthy controls. | were present when stained for COX; COX-negative (73%) and COX-superpositive (26%) fibres. Forty-two percent of the COX-negative fibres were RR-fibres and 79% of the COX-superpositive were RR-fibres. A significantly (P=0.002) higher proportion of the COX-superpositive fibres in the cleaners were RR-fibres compared to the teachers. Multivariate regression analysis revealed that age; occupation as cleaner and a tender point in the trapezius were significantly associated with increased prevalences of RR-fibres | 10666544 | [
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The prevalences of cytochrome c oxidase negative and superpositive fibres and ragged-red fibres in the trapezius muscle of female cleaners with and without myalgia and of female healthy controls. | ; a cleaner with a tender point had a 4.35 higher prevalence of RR-fibres compared to a teacher without a tender point. No correlations between other pain related variables and prevalence of RR-fibres were noted. In conclusion; RR-fibres but not COX-negative or COX-superpositive fibres were correlated with cleaning work tasks and with a tender point in the trapezius. | 10666544 | [
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Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion. | The central terminals of the primary sensory trigeminal ganglion (TG) neurons projecting into the caudal trigeminal nucleus (CTN) of the rat exhibit neurokinin A (NKA)-; substance P (SP)-; and calcitonin gene-related peptide (CGRP)-immunoreactivities (IRs). We stimulated the TG in the rat to induce some of the alterations which might occur during migraine (neurogenic inflammation). Under a stereotaxic apparatus and by means of a bipolar electrode; one-side TG of the animals were electrically stimulated (7.5 | 10666545 | [
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Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion. | Hz; 5 ms; 0.8-1. 4 mA) with square pulses for 5 min. Then; using immunohistochemical methods; the lower medulla of each rat was studied for NKA-; SP- and CGRP-IRs. Light microscopic examination of brain-stem sequencial sections revealed a simultaneous decrease in the immunoreactivities of all neuropeptides (NKA; SP and CGRP) in the CTN ipsilateral to TG stimulation in comparison with the other (not stimulated) side CTN. It is suggested that this decrease in immunoreactivity would be due to the co-release o | 10666545 | [
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Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion. | f neuropeptides following noxious stimuli and that NKA; SP and CGRP might therefore act as co-transmitters or co-modulators at the first central synapses of the trigeminal sensory pathway. | 10666545 | [
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Functional interplay between gelatinases and hyperalgesia in endotoxin-induced localized inflammatory pain. | The role of ECM-degrading proteinases in normal developmental processes and in pathological conditions is extensively studied. However; few reports describe the role ECM-degrading proteinases play in modulating hyperalgesia. The goal of this study is to describe the regulation of gelatinases during endotoxin mediated local inflammation; induced by intra plantar endotoxin (ET; 1.25 microg/50 microl) injection in Balb/c mice; and to correlate that with hyperalgesia. ET injections induced hyperalgesia; as dete | 10666546 | [
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Functional interplay between gelatinases and hyperalgesia in endotoxin-induced localized inflammatory pain. | rmined by hot plate and paw pressure tests; which peaked by 24 h and recovered by 48 h post-injection. Contralateral paw of ET injected mice and saline injected paws in control mice elicited no hyperalgesia. Zymography showed that ET and saline injected paws elicited increased gelatinase activity by 9 h after injection. However; only the former maintained high levels of expression of a 90 kD gelatinase up to at least 96 h post ET injection; while in the latter gelatinase expression was down regulated by 24 | 10666546 | [
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Functional interplay between gelatinases and hyperalgesia in endotoxin-induced localized inflammatory pain. | h. Interestingly; the 90-kD gelatinase was upregulated in the contralateral paw of the ET-injected mice beyond 48 h post injection. Saline injection in that paw; during a time when gelatinases are upregulated; induced hyperalgesia. Intraperitoneal injection of either ZnCl(2) (100 microM); thymulin (5 microg/100 microl); or morphine (2 mg/kg/100 microl) reversed the ET-induced hyperalgesia and suppressed gelatinase activity. Furthermore; intraperitoneal injection of MPI; an ECM-degrading proteinase inhibitor | 10666546 | [
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Functional interplay between gelatinases and hyperalgesia in endotoxin-induced localized inflammatory pain. | ; reversed ET induced hyperalgesia. Taken together; the above suggests that a functional interplay exists between gelatinase upregulation triggered by ET injections and hyperalgesia. The exact mechanism underlying such correlation remains to be determined. | 10666546 | [
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Intramuscular and intradermal injection of capsaicin: a comparison of local and referred pain. | The present study compared capsaicin-induced muscle and skin pain in humans. Twelve healthy subjects received; in a randomised; balanced order; 3 intramuscular (i.m.) injections into the brachioradial muscle: capsaicin 100 microg/1 ml; capsaicin 100 microg/20 microl or 1 ml solvent (Tween 80); and one intradermal injection (i.d.): capsaicin 100 microg/20 microl. Local and referred pain intensities and areas were assessed from 0 to 60 min after injection. Intradermal capsaicin produced more intense local pai | 10666547 | [
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Intramuscular and intradermal injection of capsaicin: a comparison of local and referred pain. | n than i.m. capsaicin in the first min (skin: 68+/-6; muscle: 51+/-6 mm VASxmin; P<0.05). In contrast; the local pain offset was later (muscle: 38+/-5; skin: 23+/-5 min; P<0.05) and referred pain was more frequent (muscle: 9/12; skin: 1/12 subjects; P<0.01) following i.m. capsaicin compared with i.d. capsaicin. Capsaicin (1 ml) produced significantly more pain than 20 microl i.m. (pain in the first min: 1 ml: 71+/-6; 20 microl: 51+/-6 VASxmin; P<0.05; offset: 1 ml: 50+/-4; 20 microl: 38+/-5 min; P<0.05). Th | 10666547 | [
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Intramuscular and intradermal injection of capsaicin: a comparison of local and referred pain. | e different local and referred pain following identical noxious stimulation of muscle and skin indicates that the neurophysiological mechanisms underlying skin and muscle pain differs. The model with identical noxious stimulation of muscle and skin may be suitable for the study of differences in deep and superficial pain as seen in the clinic. | 10666547 | [
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Density of sympathetic axons in sural nerve biopsies of neuropathy patients is related to painfulness. | In this study; differences of unmyelinated nerve fiber density in sural nerve biopsy material from patients suffering from neuropathies of unknown origin with (n=14) or without pain (n=13) were analyzed. Immunocytochemistry was applied to differentiate afferent sensory and efferent sympathetic nerve fibers. All patients were evaluated for deficits of small fiber function with thermotesting; quantitative sudomotor-axon reflex-testing and testing of painfulness of mechanical stimuli before performing the biop | 10666548 | [
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Density of sympathetic axons in sural nerve biopsies of neuropathy patients is related to painfulness. | sy. No difference was found between patients with and without pain concerning clinical deficits or results in any of the neurophysiological examinations. There were also no histopathological differences concerning the density of afferent C-fibers. However; absolute and relative density of efferent sympathetic nerve fibers was significantly higher in patients with painful neuropathy (P<0.001); although none of the patients demonstrated clinical sympathetic abnormalities. We conclude that an imbalance between | 10666548 | [
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Density of sympathetic axons in sural nerve biopsies of neuropathy patients is related to painfulness. | afferent and sympathetic nerve fiber density in the periphery may contribute to neuropathic pain even in those patients without obvious clinical autonomic disturbances. | 10666548 | [
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Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. | Oxycodone and morphine are structurally related; strong opioid analgesics; commonly used to treat moderate to severe pain in humans. Although it is well-established that morphine is a mu-opioid agonist; this is not the case for oxycodone. Instead; our recent studies have shown that oxycodone appears to be a kappa-opioid agonist (Ross and Smith; 1997). In the current study; we now show that co-administration of sub-antinociceptive doses of oxycodone (putative kappa-opioid agonist) with morphine (mu-opioid ag | 10666549 | [
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Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. | onist) to rats by both the intracerebroventricular and by systemic routes (intraperitoneal and subcutaneous); results in markedly increased (synergistic) levels of antinociception. Behaviourally; rats co-administered sub-antinociceptive doses of oxycodone and morphine were similar to control rats dosed with saline; whereas rats that received equi-potent doses of either opioid alone; were markedly sedated. These results suggest that co-administration of sub-analgesic doses of oxycodone and morphine to patien | 10666549 | [
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Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. | ts may provide excellent pain relief with a reduction in opioid-related CNS side-effects. Controlled clinical trials in appropriate patient populations are required to evaluate this possibility.(1) | 10666549 | [
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Bilateral hand oedema related to acupuncture. | We report the case of bilateral hand swelling following acupuncture therapy for chronic low back pain. Despite thorough history; examination and laboratory testing no systemic cause for the swelling could be elicited. This case highlights the incomplete knowledge of acupuncture mechanisms and that limited acupuncture therapy can have significant adverse effects. | 10666550 | [
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Motor cortex stimulation for chronic neuropathic pain: a preliminary study of 10 cases. | There is growing evidence to support the use of motor cortex stimulation (MCS) in the management of patients with chronic neuropathic pain. A prospective audit of ten patients using a modified staged technique for motor cortex implantation provides further evidence for the analgesic effectiveness of this technique. Ten patients suffering from phantom limb pain (n=3); post stroke pain (n=5); post traumatic neuralgia secondary to gunshot injury to the brain stem (n=1) and brachyalgia secondary to neuro-fibrom | 10666551 | [
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Motor cortex stimulation for chronic neuropathic pain: a preliminary study of 10 cases. | atosis (n=150% pain relief) and long-term benefit in 4/5 of patients who initially responded to intermittent cortical stimulation (longest follow up 31 months after implantation). Of those patients who benefited two had post stroke pain; two phantom limb pain and one post-traumatic neuralgia. We conclude that motor cortex stimulation is an effective analgesic intervention in some patients with chronic neuropathic pain; but it is difficult if not impossible to predict those patients who may respond to treatm | 10666551 | [
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Motor cortex stimulation for chronic neuropathic pain: a preliminary study of 10 cases. | ent prior to implantation. Randomised controlled trials are now urgently needed to test the effectiveness of motor cortex stimulation under double-blind conditions. | 10666551 | [
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Replication and further studies of neural mechanisms of spatial mnemonic processing in humans. | Changes in neuronal firing rates during periods of time when subjects are required to remember information (retention delays) have been reported in non-human primates. In humans; tests for such functional changes using hemodynamic markers of neural activity have typically relied on cognitive subtraction. However; the temporal resolution of fMRI allows a more direct test than that afforded by cognitive subtraction of the idea that certain brain regions may increase their neural activity during retention dela | 10666552 | [
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Replication and further studies of neural mechanisms of spatial mnemonic processing in humans. | ys in humans. Using a method that exploits this temporal resolution; increased functional activity attributable to a retention delay for spatial information in regions proximate to/within the right frontal eye field and the right superior parietal lobule were detected (in four out of four and three out of four subjects; respectively; this is an internal replication of the results of [E. Zarahn; G.K. Aguirre; M. D'Esposito; Temporal isolation of the neural correlates of spatial mnemonic processing with fMRI; | 10666552 | [
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Replication and further studies of neural mechanisms of spatial mnemonic processing in humans. | Cognit. Brain Res.; 7 (1999) 255-268. ]). Second; a model in which ventral and not dorsal prefrontal cortex in humans is involved in simply maintaining spatial information was tested. The results disputed this model as increases in fMRI signal attributable to the retention delay were detected more frequently in dorsal than ventral prefrontal cortex. Third; a model which posited that the intensity of neural activity is causally related to the accuracy of spatial mnemonic representation was tested by compari | 10666552 | [
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Replication and further studies of neural mechanisms of spatial mnemonic processing in humans. | ng retention delay signal between correct and incorrect trials. The results did not support this model in any of the regions tested. | 10666552 | [
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Neurocognition of auditory sentence comprehension: event related fMRI reveals sensitivity to syntactic violations and task demands. | The present study investigates the sensitivity of distinct brain regions to the syntactic processing of running speech. Experimental conditions varied the grammaticality of sentence types (correct vs. incorrect). Moreover; two different groups of subjects listened to the same sentence material; but followed two different task instructions. All participants were asked to listen to the auditory stimuli and to perform in a grammaticality judgment-task; whereas only half of the subjects were instructed to addit | 10666553 | [
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Neurocognition of auditory sentence comprehension: event related fMRI reveals sensitivity to syntactic violations and task demands. | ionally repair incorrect sentences covertly. Significantly increased brain responses occurred in several left temporal areas as a function of sentences' grammaticality; particularly; in the 'pure' judgment-group. Spatial extent as well as the strength of focal brain activation changed as a function of grammaticality and task demand. A generally enhanced pattern of local blood supply to the right peri-sylvian cortex could be observed when individuals additionally realized the repair-task. In particular; the | 10666553 | [
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Neurocognition of auditory sentence comprehension: event related fMRI reveals sensitivity to syntactic violations and task demands. | right inferior frontal gyrus (pars opercularis and pars triangularis) and the right temporal transverse gyrus (Heschl's gyrus) were more strongly affected by the repair-task demand. In contrast; an anterior portion of the superior temporal gyrus (planum polare) displayed increased activation bilaterally. Although left hemisphere activation varied clearly as a function of a sentence's grammaticality; the present findings demonstrate an involvement of the right peri-sylvian cortex; in particular; when task de | 10666553 | [
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Neurocognition of auditory sentence comprehension: event related fMRI reveals sensitivity to syntactic violations and task demands. | mands explicitly require an on-line repair. The results as a whole suggest a reconsideration of the notion that auditory language comprehension is restricted to the left hemisphere. The underlying mechanisms and the respective roles of both the left and the right hemisphere during speech processing are discussed. | 10666553 | [
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Learning of spatial and temporal patterns in sequential hand movements. | Speed and accuracy in performing a complex movement sequence improve with practice. To examine how the temporal and spatial patterns of movement sequence are learned; the sequence of target locations and the consistency in the timing of target presentation were manipulated independently while subjects produced a series of visually guided hand movements. When the sequence of target locations and the timing of target presentation followed a consistent pattern; performance for a particular movement sequence im | 10666554 | [
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Learning of spatial and temporal patterns in sequential hand movements. | proved with practice for both temporal and spatial movement parameters. However; when the same temporal and spatial patterns were recombined with a phase shift; there was a small but consistent deficit in performance. These results suggest that whereas spatial and temporal patterns in a learned movement sequence can be recombined flexibly; optimal performance is obtained for a specific spatio-temporal pattern of movement sequence. Whereas subjects were largely aware of the spatial and temporal patterns; the | 10666554 | [
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Learning of spatial and temporal patterns in sequential hand movements. | y were unaware of the phase-shift; suggesting that learning of a specific spatio-temporal pattern was implicit. | 10666554 | [
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False recognition in a verbal memory task: an event-related potential study. | Brain potentials were recorded from 15 healthy young subjects during the performance of a word recognition task. During the study phase; subjects had to intentionally memorise a series of words. These words were presented again together with the same number of new words in a following test phase where the instruction was to discriminate between repeated words and new words. We compared event-related potentials (ERPs) evoked by correctly identified repeated words (hits) and ERPs evoked by incorrectly classif | 10666555 | [
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False recognition in a verbal memory task: an event-related potential study. | ied new words (false alarms). Although both types of words were thought to be repeated the ERPs indicated differences between these two conditions starting at about 450 ms after the stimulus onset. These differences were mostly pronounced over frontal scalp locations but occurred also over parietal scalp locations (false alarms produced significantly more negative going ERPs than hits). We interpret that frontal and parietal brain areas show greater activation during false recognition because of a more inte | 10666555 | [
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Interhemispheric interaction in semantic categorization of pictures. | Interhemispheric processing may either increase or decrease the processing power of the brain. The two experiments presented here examined in normal subjects whether hemispheric interaction would be useful or not in semantic categorization of pictures. It was tested whether the advantages of dividing the processing between the hemispheres would increase when the experimental task was kept constant but the computational demands of the stimuli was increased. The critical stimuli were either identical (two cop | 10666556 | [
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