In this axis, skills in extraction, biotechnologies, and synthesis chemistry under microwave, are applied to different biomasses (micro/macro algae and marine bacteria), biological polymers or secondary metabolites. This way, different families of natural molecules or analog synthesis are obtained (glycomolecules, heterocyclic compounds, peptides, pigments, polyphenols) with the purpose to have anti-cancerous, cardio-metabolic, anti-microbial, and dermo-cosmetic applications.
The different skills of the team enable us to evaluate the molecules for their different biological activities: anti-proliferative, cytotoxic, regulators of tumorous progress’s process (invasion, migration, angiogenesis), anti-microbial, anti-oxidant, anti-inflammatory… (on cellular lines or molecular targets).
These projects are also accompanied by the development of technological methods for the purification and the characterization (mass spectrometry-chromatography) of biological actives.
Conception and synthesis of new pharmacologic inhibitors of key kinases in carcinogenesis. Original synthesis of new indigoid’s analogs. (diazaindoles, 3rd indolin-substitution-2-one). Valérie Thiery, Lisianne Domon, Jean-René Cherouvrier.
Sifting and identification of probiotic stems able to produce growth inhibitors. Sophie Sablé, Romain Chevrot, Sandrine Didelot, Sabrina Saltaji (PhD student).