Can anyone suggest a chiral nucleophile so this prochiral eta-3 complex becomes chiral? how would it attach?
Which complex, can you draw it and post the structure?
sorry forgot to click upload!
How about an amino acid? Cysteine.
could i use a grignard reagent? how would it add to the complex?
its got to be chiral, i need to modify the eta structure, should be a simple chiral nucleophile to add, any other ideas?
How about a chiral boron reagent?
that could work, would it add to one side of the multiple bonds leaving the other side a double bond to the other ph group? would the metal un-complex?
It may do that I'm not sure. You have an allylic double bond so I assume it would add normally.
I have no idea if it would un-complex the metal. If the C=C is gone then it may do.
It could indeed un-complex to leave a double bond. A simple chiral nucleophile would be a modified Lithium diisopropylamide (LDA) Just modify it so you form a chiral carbon on one of the alkyl parts. The good thing about using Nitrogen as the bonding point is that you need not worry about having two chiral centers next to one another as nitrogen cannot form a chiral centre. Reacting a chiral nucleophile with a PROCHIRAL electrophilic multihapto complex would yield a pair of epimers.