Is Continuous or Cyclic Oral Contraceptives Better Post-Surgery?
Ludovico Muzii, MD, from the Sapienza University of Rome, and colleagues conducted a systematic review and meta-analysis to compare a continuous versus a cyclic oral contraceptive schedule after surgical excision of ovarian endometriomas. Data were included from three randomized clinical trials and one prospective controlled study, with 557 patients with endometriosis, of whom 343 had ovarian endometriomas and completed the assigned treatment and follow-up.
The researchers found that a continuous schedule correlated with lower recurrence rates for dysmenorrhea (risk ratio, 0.24; 95% confidence interval, 0.06 to 0.91; P = 0.04). There were nonsignificant between-group differences for chronic pelvic pain and dyspareunia. Compared with a cyclic schedule, a continuous oral contraceptive schedule correlated with a nonsignificant reduction of cyst recurrence rates (risk ratio, 0.54; 95% confidence interval, 0.28 to 1.05; P = 0.07).
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