def is_multi_cool(cooler_file):
    """
    Judge a cooler is muliti-resolution cool or not.

    Parameters
    ----------
    cooler_file : str
        Path to cooler file.
    """
    import re
    if re.match('.+::.+$', cooler_file):
        return False
    import h5py
    h5_file = h5py.File(cooler_file)
    is_multi = 'pixels' not in h5_file
    h5_file.close()
    return is_multi
