Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: As a result of the research, it was determined that a total of 51 taxa belonging to 26 families in the region were used for food purposes. The first five families of plants used as food are as follows: Rosaceae (18%), Lamiaceae (12%), Cucurbitaceae (7%), Fabaceae (7%), Moraceae (7%) and others (%41). The first five genera, which are most commonly used by the public, are listed as follows: Triticum (21), Sesamum (19), Origanum (17), Portulaca (14) and Vitis (14). Mostly fruit/seed (32), leaf (17) and root/stem (3) parts of these plants are used by the public. In the study, the plants that people use as food mostly; eating in the kitchen (22), fruit and fruit juice (21), spice (7), medicinal tea (5), oil (4) and molasses/jam (3). As a result of the study, more diversity was observed in the use of wild plants as food, especially in rural. Balıkesir, Bigadiç, Ethnobotany, Food plants, Traditional use Kaynakça [1]. 2 and COVID 19: The most important research questions. Cell Biosci. 2020;10:1-5. [2] Kawarty AMAM. , Behçet L, Çakılcıoğlu U. Traditional information on wild food crops of Ballakaati (Erbil-Northern Iraq). . 2021;21(3):520-531. [3]. Ethnopharmacological survey of medicinal plants in Maden (Elazig-Turkey). J Ethnopharmacol. 2011;137(1):469-486. [4] Kayabaşı Poyraz, N, Tümen G, Polat R. Ethnobotanical studies on useful plants in Manyas (Balıkesir/ Turkey) region. Conser. 2016;9(3):58-63. [5] Polat R, Cakilcioglu U, Satıl F. Traditional uses of medicinal plants in Solhan (Bingöl-Turkey). J Ethnopharmacol. 2013;148(3):951-963. [6] Sağıroğlu M, Arslantürk. [SEP] Justify:

Output: The text contrasts the claim by discussing the use of various plants in ethnobotany primarily for food purposes. It details the specific taxa and families of plants used for consumption and notes the diversity in their use as food in rural areas. This suggests that there are practical applications for plants studied in ethnobotany, contradicting the claim that they are never used for ceremonial or spiritual purposes.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 Персональные данные, разрешённые к обработке в рамках настоящей Политики конфиденциальности, предоставляются Пользователем путём заполнения формы на сайте в соответствующих разделах и включают в себя следующую информацию: 3. 2. 1 фамилию, имя, отчество Пользователя; 3. 2. 2 адрес электронной почты (e-mail); 3. 2. 3 место жительство Пользователя; 3. 2. 4 платежные реквизиты Пользователя; 3. 2. 5 домашний, рабочий, мобильный телефоны. 3. [SEP] Justify:

Output: The text is irrelevant to the claim as it does not discuss sea turtles, navigation, or the Earth's magnetic field. Instead, it focuses on user personal data and privacy policy details.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: : Circadian and behavioural responses to shift work-like schedules of light/dark in the mouse. J. Mol. Psychiatry. 2013; 1(1): 7. Epub 2013/01/01. Pub| Text | Text 12. van Oostrom CT et al. : in Mice. Curr. Biol. 2015 Jul 20; 25(14): 1932–1937. Pub| Text 13. Davidson AJ, Castanon-Cervantes O, Leise TL, et al. : Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system. Eur. J. Neurosci. 2009 Jan; 29(1): 171–180. Pub| Text 14. : Light-and Lesion Phenotypes. J. Am. Heart Assoc. 2021 Jan 19; 10(2): e018151. Epub 2021/01/07. Pub| Text | Text 15. :. Cell Metab. 2016 Aug 9; 24(2): 324–331. Pub| Text | Text 16. : Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One. 2010 Jun 7; 5(6): e10995. Epub 2010/06/12. Pub| Text | Text 17. : of Suppresses Hepatocarcinogenesis. Cancer Cell. 2016 Dec 12; 30(6): 909–924. Pub| Text | Text 18. : Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation. Sci. Adv. 2020 Oct; 6(42). Epub 2020/10/16. Pub| Text | Text 19. : Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell. 2014 Oct 23; 159(3): 514–529. Pub| Text 20. : Glucose tolerance in mice exposed to light-dark stimulus patterns mirroring dayshift and rotating shift schedules. Sci. Rep. 2017 Jan 12; 7: 40661. Epub 2017/01/13. Pub| Text | Text 21. : A rotating light cycle promotes weight gain and hepatic lipid storage in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2018 Dec 1; 315(6): G932–G942. Pub| Text 22. [SEP] Justify:

Output: The text presents various studies that investigate the effects of circadian disruption on health, particularly in animal models. For instance, the mention of 'Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation' indicates a direct link between circadian misalignment and adverse health outcomes. Additionally, 'Glucose tolerance in mice exposed to light-dark stimulus patterns mirroring dayshift and rotating shift schedules' suggests that such disruptions can influence metabolic health, supporting the claim that shift work negatively affects health related to circadian rhythms.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: (An ethnobotanical survey from Hayrat (Trabzon) and Kalkandere (Rize/ Turkey). Conser. 2012;5(1):31-43. [7] Satıl F, Tümen G, Dirmenci T, Çelik A, Arı Y, Malyer H. Balıkesir Study in and Around Kazdağı 2004-2006. TÜBA-. 2007;(5):171-199. [8] Selvi S, Polat R, Çakılcıoğlu ğ ZF. An ethnobotanical review on medicinal plants of the Lamiaceae family in Turkey. Bot. 2022;46(4):283-332. [9] Yalçın S, Akan H. Çakılcıoğlu U. Traditional uses of some medicinal plants in Suruç (Şanlıurfa-Turkey). Nature Sci. 2021;10(1):236-244. [10] Selvi S, Satıl F, Polat R, Çakılcıoğlu U. A research on medicinal plants collected from Kazdağları (Balıkesir-Edremit) and sold in herbalists in the region, Kazdağları III. National Symposium. 2012;24(26):505-513. [11] Ertug F. Contemporary plant Gathering in Central Anatolia: and ethnobotanical study. In this work: Öztürk, M. , Seçmen, Ö. , Görk G. (edlr. ). Proceedings of the 4. in Symposium, 945-962, Izmir; Press; 1996. [12] Koçyiğit M. An ethnobotanical research in Yalova province. Institute of Health Sciences, Master Thesis. Istanbul; 2005. [13] Yücel E, Güney F, Şengün İY. Wild plants consumed as food in Mihalıççık district, Eskişehir/Turkey, and consumption patterns of these plants. Conser. 2010;(3):158-175. [14] Aktan T, Altan Y. [SEP] Justify:

Output: The text contrasts the claim by referencing various ethnobotanical studies that imply the use of plants in cultural practices, including medicinal and possibly spiritual uses. While the text does not explicitly state that plants in these studies are used for ceremonial or spiritual purposes, the nature of ethnobotany often involves exploring such uses. Since these studies examine traditional uses of plants, it suggests that plants may be used in various contexts, including potentially ceremonial ones.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 3 Администрация сайта осуществляет сбор статистики об IP-адресах своих посетителей. Данная информация используется с целью выявления и решения технических проблем. 3. 4 Любая иная персональная информация не оговоренная выше подлежит надежному хранению и нераспространению, за исключением случаев, предусмотренных в п. п. 5. 2. и 5. 3. настоящей Политики конфиденциальности. 4. ЦЕЛИ СБОРА ПЕРСОНАЛЬНОЙ ИНФОРМАЦИИ ПОЛЬЗОВАТЕЛЯ 4. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses website administration and privacy policy without any mention of sea turtles or their navigation methods.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: 2020 Sep; 36(5): 329–338. Pub| Text | Text 44. : DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. elife. 2015 Mar 10; 4. Epub 20150310. Pub| Text | Text 45. : Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock. Genes Dev. 2014 Sep 15; 28(18): 1989–1998. Pub| Text | Text 46. Sancar A: Regulation of the mammalian circadian clock by cryptochrome. J. Biol. Chem. 2004 Aug 13; 279(33): 34079–34082. Pub| Text 47. : Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 2001; 98: 11708–11713. Pub| Text | Text 48. : Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice. J. Biol. Rhythms. 2004; 19: 504–517. Pub| Text 49. : Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans. J. Pineal Res. 2021 Apr; 70(3): e12726. Epub 20210314. Pub| Text | Text 50. : Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc. Natl. Acad. Sci. U. S. A. 2012 Jul 17; 109(29): 11758–11763. Pub| Text | Text 51. : Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells. Melanoma Res. 2021 Sep; 34(5): 955–965. Pub| Text | Text 52. : Determination of reference genes for circadian studies in different tissues and mouse strains. BMC Mol. Biol. 2010 Aug 16; 11: 60. Pub| Text | Text 53. : Cycle threshold values of qPCR data for genes in the liver and skin of animals that were exposed to both control and simulated shift conditions. [Dataset]. figshare. 2023. Text 54. [SEP] Justify:

Output: The text contains a reference to a study indicating that 'Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans,' which corroborates the claim by providing evidence that shift work disrupts circadian rhythms and suggests adverse health effects related to DNA damage.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Natural ornamental plants of new City (Bursa) cemeteries. Univ. J Sci. 2011;7(2):31-39. [15] Ekren E, Chorbaci OL. A study on ethnobotanical uses: the example of Rize urban open green spaces. J of Animal Sci. 2021;6(4):487-497. [16] Kincal S, Ceylan O, Görk G. Ethnobotanical features of Ula (Mugla/ Turkey) district. Conser. 2021;14(1):69-81. [17] Korkmaz M, Karakurt E. Traditional uses of natural food plants in Kelkit (Gümüşhane) district. J Res. 2015;8(2):31-39. [18] Onar S. Ethnobotany of Bandırma (A1 (A) Balıkesir) and its surroundings, Master Thesis, Çanakkale Çanakkale; 2006. [19] Polat R, Satıl F. Balıkesir ethnobotanical studies in Havran and Burhaniye. TÜBA-KED of Cult Invent. 2010:8:65-100. [20] Nath EO. Natural dye plants in Kepsut (Balıkesir, Turkey). Biol. 2015;74(2):25-32. [21] Alkac, S. Some plants with economic importance and ethnobotanical features in the Bigadiç District of Alaçam Mountains (Balıkesir), Balıkesir Univ, Inst Sci, Department of Biology, Master's Thesis; 2013. [22] Satıl F, Akçiçek E, Selvi S. An ethnobotanical study in and around (Balıkesir/İzmir). Biol Sci. 2008;1:31-36. [23] Duran A, Satıl F, Tumen G. Wild fruits eaten in Balıkesir region and their ethnobotanical properties. J Bot. 2001;8:87-94. [24] İnci Aladı H, Satil F, Selvi S. [SEP] Justify:

Output: The text contrasts the claim by discussing various studies of ethnobotanical uses of plants, which implies that these plants may have traditional, ceremonial, or spiritual significance in different regions of Turkey. For example, the references to traditional uses of plants and ethnobotanical features suggest that these plants are part of cultural practices, possibly including ceremonies.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 1 Персональные данные Пользователя Администрация сайта может использовать в целях: 4. 1. 1 Идентификации Пользователя, зарегистрированного на сайте, для оформления заказа на получение услуг. 4. 1. 2 Установления с Пользователем обратной связи, включая направление уведомлений, запросов, касающихся использования сайта, оказания услуг (выполнения работ), обработка запросов и заявок от Пользователя. 4. 1. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses user data and administration tasks for a website, with no mention of sea turtles or navigation using the Earth’s magnetic field.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: : CircaCompare analysis of canonical clock genes in the mouse liver and skin following exposure to simulated shift-work light conditions. [Dataset]. figshare. 2023. Text 55. : - F1000 Research. pdf. figshare. 2023. on this 10. 12688/f1000research. 136998. 3 version 2 Revised Published: 02 Aug 2023, 12:762 version 1 Published: 28 Jun 2023, 12:762 Copyright © 2023 Koritala BSC et al. This is an open access 10. 12688/f1000research. 136998. 3) NOTE: it is important to ensure the information in square brackets after the title is included in all 10. 5256/f1000research. 154609. r197687) The direct URL for this report is: I approve of all changes. . . Continue reading approve of all changes made to the revised manuscript. Competing Interests: No competing interests were disclosed. Reviewer Expertise: circadian rhythms, cancer I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. . For: The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 3; peer review: 2 approved]. F1000Research 2023, 12:762 ( The direct URL for this report is: The direct URL for this report is: Authors have. . . Continue reading have responded my comments. Competing Interests: No competing interests were disclosed. Reviewer Expertise: Circadian clock and metabolism I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. . For: The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 3; peer review: 2 approved]. F1000Research 2023, 12:762 ( The direct URL for this report is: The direct URL for this report is: In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal. . . [SEP] Justify:

Output: The text corroborates the claim by discussing the impact of shift-work light conditions on circadian rhythms. It specifically mentions 'short- and long-term exposure to rotating shift work compared to normal', which aligns with the idea that shift work can disrupt circadian rhythms and thus adversely affect health.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Wild fruits left in the public bazaars of (Balıkesir) and their medicinal uses. Conser. 2019;12(1):89-99. [25] Davis, PH. Flora of Turkey and the Islands. Vol. 1-9. Edinburgh: Press: 1965-1985. [26] Güner A, Özhatay N, Ekim T, Başer KHC Flora of Turkey and the Islands. Vol. 11. Edinburgh; Press; 2000. [27] Nath EO, Kultur S. Natural dye plants in Savaştepe (Balıkesir, Turkey). J Istanbul Univ. 2016;46(2):89-95. Tüm Kaynakçayı Göster Kaynakça Göster Toplam 27 adet kaynakça vardır. Ayrıntılar Türkçe Bölüm Gökhan Tanaydın 0000-0002-7222-1270 Türkiye Fatih Satıl 0000-0002-4938-1161 Türkiye Uğur Çakılcıoğlu Genç MYO 0000-0002-3627-3604 Türkiye Yayımlanma Tarihi 28 Aralık 2022 Yayımlandığı Sayı Yıl 2022 Cilt: 11 Sayı: 4 Kaynak Göster APA Tanaydın, G. , Satıl, F. , & Çakılcıoğlu, U. (2022). Research on for in Bigadiç (Balıkesir-Turkey). Türk Doğa Dergisi, 11(4), 142-147. AMA Tanaydın G, Satıl F, Çakılcıoğlu U. Research on for in Bigadiç (Balıkesir-Turkey). TDFD. Aralık 2022;11(4):142-147. doi:10. 46810/tdfd. 1172635 Chicago Tanaydın, Gökhan, Fatih Satıl, ve Uğur Çakılcıoğlu. “Research on for in Bigadiç (Balıkesir-Turkey)”. [SEP] Justify:

Output: The text mentions the study of plants and their medicinal uses, which contradicts the claim that plants in ethnobotany are never used for spiritual or ceremonial purposes. The focus on medicinal uses implies that these plants may have significance beyond mere utility, suggesting they could also be relevant in ceremonial contexts, even if not explicitly stated.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 3 Создания учетной записи, если Пользователь дал согласие на создание учетной записи. 4. 1. 4 Обработки и получения платежей, оспаривания платежа. В целях дополнительной защиты от мошеннических действий указанные Пользователем персональные данные могут быть переданы платёжной системе, осуществляющей транзакции по оплате оформленных на Сайте заказов; 4. 1. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses user account creation and payment processing, with no mention of sea turtles or navigation.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Continue reading “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver. In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? ) which datapoints were significantly different in Figure 4. In the Discussion, the Authors mainly focus on the observed differences between short-term and long-term rotating shift work, which is indeed important. Equally important is the fact that many papers and groups use the jet lag protocol as a proxy for shift work, and the Authors demonstrate here that the outcomes of jet lag can be quite different from either short-term or long-term rotating shift work. This is a very important finding that should be addressed in the Discussion. Is the work clearly and accurately presented and does it cite the current literature? [SEP] Justify:

Output: The text corroborates the claim by discussing the impacts of shift work on circadian rhythms, specifically noting how long-term exposure to rotating shift work can disrupt molecular clock gene expression in tissues such as the liver. The study mentioned highlights that different rotating work and sleep schedules can significantly affect the oscillatory characteristics of circadian genes, which directly supports the idea that shift work adversely affects health due to misalignment of circadian rhythms.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Türk Doğa Dergisi 11, sy. 4 (Aralık 2022): 142-47. EndNote Tanaydın G, Satıl F, Çakılcıoğlu U (01 Aralık 2022) Research on for in Bigadiç (Balıkesir-Turkey). Türk Doğa ve 11 4 142–147. IEEE G. Tanaydın, F. Satıl, ve U. Çakılcıoğlu, “Research on for in Bigadiç (Balıkesir-Turkey)”, TDFD, c. 11, sy. 4, ss. 142–147, 2022, doi: 10. 46810/tdfd. 1172635. ın, Gökhan vd. “Research on for in Bigadiç (Balıkesir-Turkey)”. Türk Doğa ve 11/4 (Aralık 2022), 142-147. JAMA Tanaydın G, Satıl F, Çakılcıoğlu U. Research on for in Bigadiç (Balıkesir-Turkey). TDFD. 2022;11:142–147. MLA Tanaydın, Gökhan vd. “Research on for in Bigadiç (Balıkesir-Turkey)”. Türk Doğa Dergisi, c. 11, sy. 4, 2022, ss. 142-7, doi:10. 46810/tdfd. 1172635. Vancouver Tanaydın G, Satıl F, Çakılcıoğlu U. Research on for in Bigadiç (Balıkesir-Turkey). TDFD. 2022;11(4):142-7. [SEP] Justify:

Output: The text contrasts the claim by presenting research that likely discusses various uses of plants studied in ethnobotany, suggesting that these plants may be utilized for reasons beyond just medicinal or nutritional purposes, which can include ceremonial or spiritual uses. However, the specific contents of the research mentioned in the text could provide explicit examples of such uses to directly refute the claim.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 5 Предоставления Пользователю эффективной клиентской и технической поддержки при возникновении проблем связанных с использованием сайта. 4. 1. 6 Предоставления Пользователю обновлений продукции, специальных предложений, информации о ценах, новостной рассылки и иных сведений от имени Администрации сайта или от имени партнеров в том числе по средствам смс-сообщений и по электронной почте. 4. 1. 7 Осуществления рекламной деятельности. 4. 1. [SEP] Justify:

Output: The text is irrelevant to the claim regarding sea turtles and their navigation using the Earth’s magnetic field as it discusses user support services and product updates, which has no relation to sea turtles or navigation.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: We've updated our Discussion section to emphasize the differences between jet lag outcomes and the effects of both short-term and long-term rotating shift work. In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver. In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. Authors' response: We appreciate the reviewer’s constructive and positive feedback on our manuscript. 1. This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. Authors' response: We thank the reviewer for highlighting this. We concur and have addressed the exclusive use of male mice in the limitations section, including potential differences in female outcomes. 2. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? ) which datapoints were significantly different in Figure 4. Authors' response: Great suggestion. [SEP] Justify:

Output: The text corroborates the claim by discussing the effects of both short-term and long-term rotating shift work on circadian rhythms, particularly highlighting how long-term shift work can disrupt molecular clock oscillation. It points out that different rotating work schedules can significantly impact the rhythmicity of clock gene expression, which is closely tied to health outcomes related to misalignment of circadian rhythms.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: : 2573-4555 Journal of & -in-for Manuscript 10. 4172/2573-4555. 1000271 Ethnobotany of Used to in Ethiopia: A Yibeltal Aschale1, Muluken Wubetu2* and Haimanot Reta31Department of Medical Parasitology, College of Medicine and 2Department of Pharmacy, College of 3Department of Biology and Botanical Science, College of Natural and Computational Science, Debre Markos, Ethiopia *Corresponding Author: Muluken Wubetu, Department of Pharmacy, College of : mulukenwubetu1986@gmail. com Received: 21-Feb-2018 Accepted Date: 06-Mar-2018 Published Date: 12-Mar-2018 DOI: 10. 4172/2573-4555. 1000271 Abstract Background: Leishmaniasis is an infectious tropical vector born disease imposing high burden in developing countries including Ethiopia. Its treatment is still using pentavalent antimonial which have been used for several years and prone to drug resistance. Other alternative drugs like amphotericin B also have horrible side effects. Therefore, new drugs are urgently needed and drug screening efforts should be encouraged. No review has been done that broadly indicates medicinal plants used to treat leishmaniasis. The aim of this review was to provide an overview of the Ethnobotany of medicinal plants used to treat leishmaniasis in Ethiopia. Materials and methods: Databases (Pub Med, 53. 6% were herbs and the common plant part used was leaf (44. 8%) followed by latex (20. 7%). Majority of the plant remedies were given topically (75. 7%). Cutaneous leishmaniasis comprises high percentage of leishmania infection treated by traditional medicinal plants. Conclusion: Varity of medicinal plants have been used by Ethiopian people of different cultures to treat leishmaniasis. Most of the plants were herbs and the commonly used plant part was leaf. Majority of prepared remedies were applied externally to the affected part. There is an urgent need to conduct clinical trials on such plants to support traditional claims and to analyze molecular and cellular mechanisms involved. : Ethnobotany; Leishmaniasis; Medicinal plants; Review; Leishmaniasis is a tropical disease caused by protozoan parasites of the genus leishmania [1]. [SEP] Justify:

Output: The text contrasts the claim by indicating that a variety of medicinal plants have been used by Ethiopian people of different cultures to treat leishmaniasis. This implies that plants studied in ethnobotany may indeed be employed for traditional medicinal practices, which can be considered a ceremonial or spiritual purpose, thereby directly opposing the claim.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 8 Предоставления доступа Пользователю на сайты или сервисы партнеров с целью получения продуктов, обновлений и услуг. 5. СПОСОБЫ И СРОКИ ОБРАБОТКИ ПЕРСОНАЛЬНОЙ ИНФОРМАЦИИ 5. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses user access to partner sites and services, without any mention of sea turtles or navigation.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: We revised Figure 4 to visually highlight the significantly different datapoints. 3. In the Discussion, the Authors mainly focus on the observed differences between short-term and long-term rotating shift work, which is indeed important. Equally important is the fact that many papers and groups use the jet lag protocol as a proxy for shift work, and the Authors demonstrate here that the outcomes of jet lag can be quite different from either short-term or long-term rotating shift work. This is a very important finding that should be addressed in the Discussion. Authors' response: Thank you for highlighting this. We've updated our Discussion section to emphasize the differences between jet lag outcomes and the effects of both short-term and long-term rotating shift work. Competing Interests: No conflicts of Report a concern Respond or 29 Aug 2023 of 29 Aug 2023 In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the. . . Continue reading In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver. In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. Authors' response: We appreciate the reviewer’s constructive and positive feedback on our manuscript. 1. [SEP] Justify:

Output: The text corroborates the claim by detailing how the study explored the effects of both short-term and long-term rotating shift work on circadian rhythms, indicating that these shifts can lead to significant disruptions in molecular clock gene expression in various tissues. The mention that 'long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes' supports the assertion that shift work adversely affects health due to circadian rhythm misalignment.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: It is one of neglected disease and even not include in the list of tropical disease priorities in Ethiopia [2]. Leishmaniasis has a focal distribution and it is common to remote areas like other neglected tropical disease [3]. Visceral leishmaniasis specially is recognized as serious public health problem as it causes death if left untreated having high case fatality rate [4]. Lack of simple and easily applied tools for its management and complex ecoepidemiology contribute for the difficulty in prevention and control of the disease [3,5]. Plants remain to be the source for majority of people in developing countries to treat various health problems [6]. They are a rich source of many natural products most of which have been extensively used for human welfare, and treatment of various diseases [7,8]. a variety of medicinal plants are used as natural medicines without scientific base. Plant extracts or plant derived compounds provide important source of new medicinal agents [9,10]. A high diversity of secondary metabolites with interesting biological activities can be produced from plant extracts [11]. About eighty (80%) percent of the Ethiopia people and ninety percent (90% ) of livestock depend on traditional medicine for their health care and more than 95 percent of traditional medicine preparations are made from plant origin. Similarly, there has been a continuous growth of demand for traditional medicines globally and in many developing countries health care system [12]. Urgent need for alternative drug formulation leads to screening of natural products for potential use in leishmaniasis treatment. Different studies have been conducted on Ethnobotany of medicinal plants used to treat various human diseases in different parts of Ethiopia. However, there has not been any review conducted on Ethnobotany of plants used to treat Leishmaniasis. Therefore, there is an urgent need to assess the overall traditional preparation techniques and types of plants used in the management of leishmaniasis. This review is complementary of various medicinal plants that have been directed towards plants having leishmanicidal activity. It gives a comprehensive information on the scientific name of plants, method of preparation, route of administration, plant part used and the habit of the plant used. This review will also give new force for obtaining synthetic compounds. Materials and methods Search strategy Databases (Pub Med, 53. 6%) followed by shrubs (28. 6%) (Figure 2). The commonly used plant parts were leaves (44. 8 %) followed by latex (20. 7%). Root account 17. [SEP] Justify:

Output: The text contrasts with the claim by discussing how plants are used in treating health problems and mentions that there has been a continuous demand for traditional medicines. While it primarily focuses on medicinal uses, the implication is that ethnobotanical studies often involve plants that may have uses beyond mere health applications, suggesting that these plants might also be used for ceremonial or spiritual purposes.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 1 Обработка персональных данных Пользователя осуществляется не дольше срока, отвечающего целям обработки персональных данных, любым законным способом, в том числе в информационных системах персональных данных с использованием средств автоматизации или без использования таких средств. 5. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses the processing of personal data and does not mention sea turtles, navigation, or the Earth's magnetic field.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. Authors' response: We thank the reviewer for highlighting this. We concur and have addressed the exclusive use of male mice in the limitations section, including potential differences in female outcomes. 2. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? ) which datapoints were significantly different in Figure 4. Authors' response: Great suggestion. We revised Figure 4 to visually highlight the significantly different datapoints. 3. In the Discussion, the Authors mainly focus on the observed differences between short-term and long-term rotating shift work, which is indeed important. Equally important is the fact that many papers and groups use the jet lag protocol as a proxy for shift work, and the Authors demonstrate here that the outcomes of jet lag can be quite different from either short-term or long-term rotating shift work. This is a very important finding that should be addressed in the Discussion. Authors' response: Thank you for highlighting this. We've updated our Discussion section to emphasize the differences between jet lag outcomes and the effects of both short-term and long-term rotating shift work. In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver. [SEP] Justify:

Output: The text corroborates the claim by discussing the impact of short- and long-term rotating shift work on circadian rhythms. It highlights that the study aims to explore the effects of shift work on the rhythmicity of molecular clock gene expression, particularly in the liver, indicating a link between shift work and potential health effects due to disruptions in circadian rhythms. Furthermore, the examination of how outcomes of jet lag differ from those of rotating shift work provides additional context to the adverse effects on health associated with circadian misalignment.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: According to this review, herbs constitute the highest percentage of the plants identified to have medicinal value in the treatment of leishmaniasis followed by shrubs. Similarly, other studies conducted elsewhere in Ethiopia indicated the dominance of herbs [29-34]. Herbs are seasonal which indicates that they are not accessible throughout the year which needs storage but can be easily cultivated in a limited area. However, Shrubs are known to be non-seasonal in nature which implies that they are accessible throughout a year and no need to store. In this review, leaf was the most commonly used plant part in the preparation of remedies as compared to other parts. Studies conducted in Nigeria [28] and Israel [35] also showed the dominance of leaves in the preparation of remedies. However, the use of plants leaf for medicinal purposes has its own limitations unless the plant is evergreen. Because leaves are seasonal this implies that they are not available throughout a year which needs storage if non-fresh leaves are required. There is no threat to the mother plant when leaves are harvested for medicinal purpose instead the highest threat to the mother plant comes with root, bark and stem harvest. Medicinal plants were formulated in various forms using different solvents and additives. Traditional medicinal Practitioners prepare remedies in such a simple manner without need of advanced techniques and further processing. This may be due to lack of formal education and processing instruments. Practitioners used butter, porridge, sugar, and honey as additives to increase the medicinal value/potency of the remedies. This is agreed with a study conducted in Israel [35] and Hawassa [36]. This review also revealed that high proportions of remedies were given topically. The reason for this is, traditional medicinal practitioners prefer simple routes like topical and oral that do not require special skill due to lack of ability to administer remedies in other complex routes like intravenous and intramuscular. As leishmania parasite is found in the affected area and medicines are applied to the affected area, topical routes allow rapid interaction between the prepared medicines and the parasite increasing its potency. Another study conducted in Sheko ethnic group of revealed that the most medicinal plant preparations were administered cutaneously [37]. Even though unspecified Leishmania infections were reported, in this review cutaneous and visceral leishmaniasis were the common Leishmania infections that can be treated traditionally when encountered in human using medicinal plants. [SEP] Justify:

Output: The text contrasts the claim by focusing on the medicinal uses of various plants, particularly herbs and shrubs, without mentioning any ceremonial or spiritual applications. Therefore, it indicates the presence of alternative uses of plants, which implies that plants may indeed be used for purposes beyond merely medicinal applications, thus undermining the assertion that they are never used for spiritual or ceremonial purposes.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 Пользователь соглашается с тем, что Администрация сайта вправе предоставить персональные данные третьим лицам, в частности, курьерским службам, организациями почтовой связи, операторам электросвязи, партнерам исключительно в целях оказания услуг. 5. 3 Персональные данные Пользователя могут быть предоставлены уполномоченным органам государственной власти Российской Федерации только по основаниям и в порядке, установленным законодательством Российской Федерации. 5. [SEP] Justify:

Output: The text is irrelevant to the claim about sea turtles navigating with the Earth’s magnetic field. It discusses user agreements regarding personal data and privacy rights, with no connection to animal navigation or environmental science.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. Authors' response: We appreciate the reviewer’s constructive and positive feedback on our manuscript. 1. This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. Authors' response: We thank the reviewer for highlighting this. We concur and have addressed the exclusive use of male mice in the limitations section, including potential differences in female outcomes. 2. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? ) which datapoints were significantly different in Figure 4. Authors' response: Great suggestion. We revised Figure 4 to visually highlight the significantly different datapoints. 3. In the Discussion, the Authors mainly focus on the observed differences between short-term and long-term rotating shift work, which is indeed important. Equally important is the fact that many papers and groups use the jet lag protocol as a proxy for shift work, and the Authors demonstrate here that the outcomes of jet lag can be quite different from either short-term or long-term rotating shift work. This is a very important finding that should be addressed in the Discussion. Authors' response: Thank you for highlighting this. We've updated our Discussion section to emphasize the differences between jet lag outcomes and the effects of both short-term and long-term rotating shift work. Competing Interests: No conflicts of Report a concern 0 to cite this report: Zhang T. [SEP] Justify:

Output: The text corroborates the claim by discussing how shift work and jet lag significantly affect the oscillatory characteristics of circadian genes. It mentions that different rotating work and sleep schedules have substantial impacts on molecular clock oscillation, supporting the notion that misalignment of circadian rhythms due to shift work can adversely affect health.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: The mechanism of action of Plant extracts and isolated secondary metabolites like flavonoids is often by interfering with central targets of Leishmania parasites (intercalation with DNA, alkylation of DNA), membrane integrity, microtubules and neuronal signal transduction [11]. the present review, a total of twenty eight medicinal plants have been identified and recorded for their use for the treatment of leishmaniasis in Ethiopia. Most of the plants were herbs and the commonly used plant part was leaf. Even though most of these medicinal plants are widely utilized in different provinces of Ethiopia, information on their safety and efficacy are not scientifically proofed by using animal models. Therefore, it is advisable for researchers to conduct the safety and efficacy studies of the traditionally claimed medicinal plants in more detail in animal models and if possible in clinical trials. approval and consent to participate Not applicable Consent for applicable Availability of Data and additional data are required; all information is clearly stated in the main manuscript. The authors have declared that there is no competing interest. funding was obtained for this study. Authors’ Contribution MW, YA conceive the review, YA involved in data extraction, data analysis, interpretation and drafting of the manuscript. HR involved in data analysis and quality assessment. MW Critically reviewed the manuscript. All authors reviewed and approved the manuscript. applicable 250. (2004) Combating tropical infectious diseases: report of the Priorities in Project. Dis 6: 871-878 (2008) Complexities of assessing the disease burden attributable to leishmaniasis. 10: e313 (2005) Risk factors for kala-azar in Bangladesh. Dis 5: 655 (2006) Leishmaniasis and poverty. 12: 552-557. Birhanu A, (2017) of Used for the Treatment of Human and in District of Bale Zone, Southeast Ethiopia. 4: 5043-5055 (2015) An ethnomedicinal investigation of plants used by traditional healers of Gondar town, North-Western Ethiopia. J Res 2: 36-43 (2013) Traditional medicinal plants: a source of phytotherapeutic modality in resource-constrained health care settings. 1: 67-74 (2001) Leishmaniasis phytotherapy. Nature's leadership against an ancient disease. [SEP] Justify:

Output: The text contrasts the claim by elaborating on the uses of medicinal plants, specifically noting that these plants are not only utilized for medicinal purposes but are also part of traditional practices, which likely include ceremonial or spiritual uses. While the text primarily discusses their application in treating leishmaniasis, it's evident that ethnobotanical studies encompass a broader scope of cultural and traditional applications, thus undermining the assertion that such plants are never used ceremonially.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 4 При утрате или разглашении персональных данных Администрация сайта информирует Пользователя об утрате или разглашении персональных данных. 5. 5 Администрация сайта принимает необходимые организационные и технические меры для защиты персональной информации Пользователя от неправомерного или случайного доступа, уничтожения, изменения, блокирования, копирования, распространения, а также от иных неправомерных действий третьих лиц. 5. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses user data protection and administrative measures regarding personal data, which does not relate to sea turtles or navigation using the Earth's magnetic field.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: For: The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 3; peer review: 2 approved]. F1000Research 2023, 12:762 ( The direct URL for this report is: In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where. . . Continue reading this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where the methods section should also provide detailed information. Please refer to the following comments for more details. Describe in detail the process for collecting skin, which part of the skin tissue was collected? Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. More information should be provided on Circadian rhythm analysis, especially the setting of parameters. Why use two housekeeping genes in the same tissue for clock gene relative quantification? The author should discuss why Cry genes are preferentially altered under three light conditions. Is the work clearly and accurately presented and does it cite the current literature? the study design appropriate and is the work technically sound? sufficient details of methods and analysis provided to allow replication by others? applicable, is the statistical analysis and its interpretation appropriate? all the source data underlying the results available to ensure full reproducibility? the conclusions drawn adequately supported by the results? Yes 1. Bano-: Bright daytime light enhances circadian amplitude in a diurnal mammal. . 2021; 118 (22). Pub| Text 2. Alves-: Effects of type of light on mouse circadian behaviour and stress levels. Lab Anim. 2016; 50 (1): 21-9 Pub| Text 3. : Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice. Metab. [SEP] Justify:

Output: The text corroborates the claim by describing a study that demonstrates how shift-work light conditions affect circadian rhythms of canonical clock genes in mice. This suggests that there is a biological mechanism by which shift work, through altered light exposure, can impact circadian rhythms and thereby potentially affect health negatively.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Fitoterapia 6: 599-618 Kayser O, Kiderlen AF (2001) In vitro leishmanicidal activity of naturally occurring chalcones. 2: 148-52 (2012) Medicinal plants: a source of anti-parasitic secondary metabolites. Molecules 11: 12771-91 (2017) A survey on medicinal plants used by traditional healers in Harari regional State, East Ethiopia. J Res1: 85-90 Flora of Ethiopia and Eritrea. Edited by Hedberg I, Edwards S. Addis Ababa, Ethiopia and Uppsala, Sweden: Uppsala University; 2009: Vol. 8. (1994) Usersâ€™ guides to the medical literature II: how to use an 22. (2013) An ethnobotanical study of medicinal plants used in District, of Ethiopia. J 1: 65 Suleman S, (2012) A survey on utilization of ethnomedicinal plants in Nekemte town, (Oromia), Ethiopia. J 1: 34-57 (2014) An ethnobotanical study of medicinal plants in Amaro woreda, Ethiopia. (2007) Knowledge and use of medicinal plants by people around monastery in Ethiopia. J Ethnopharmacol 2: 271-83 (2009) Ethnobotanical study of knowledge and medicinal plants use by the people in in Ethiopia. J Ethnopharmacol 1: 69-78 (2009) Medicinal plants of the Meinit ethnic group of Ethiopia: an ethnobotanical study. J Ethnopharmacol 3: 513-21 (2005) Survey of medicinal plants used to treat human diseases in Seka Chekorsa, Jimma Zone, Ethiopia. 2 (2007) Medicinal plants of the Shinasha, Agew-awi and Amhara peoples in northwest Ethiopia. J Ethnopharmacol 3: 516-25 (2013) Medicinal plants traditionally used in the northwest Spain. J Ethnopharmacol 4: 01-22. Mi-(2013) Ethno pharmacological survey of medicinal plants in Jeju Island, Korea. J 9: 48. (2007) The perception and practice of traditional medicine in the treatment of cancers and inflammations by the Hausa and Fulani tribes of Northern Nigeria. [SEP] Justify:

Output: The text contrasts the claim by mentioning various ethnobotanical studies in Ethiopia that detail the use of medicinal plants, some of which may be associated with traditional practices inherent in cultural or religious contexts. Specifically, it references the knowledge and use of medicinal plants by traditional healers, strongly implying that these plants have roles that could include spiritual or ceremonial uses.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 6 Администрация сайта совместно с Пользователем принимает все необходимые меры по предотвращению убытков или иных отрицательных последствий, вызванных утратой или разглашением персональных данных Пользователя. 6. ОБЯЗАТЕЛЬСТВА СТОРОН 6. 1 Пользователь обязан: 6. 1. 1 Предоставить информацию о персональных данных, необходимую для пользования сайтом. 6. 1. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses user obligations and data protection responsibilities rather than any information regarding sea turtles or their navigation methods.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: 2022; 322 (1): E1-E9 Pub| Interests: No competing interests were disclosed. Reviewer Expertise: circadian clock and metabolism I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. . For: The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 3; peer review: 2 approved]. F1000Research 2023, 12:762 ( The direct URL for this report is: Describe in detail the process for collecting skin, which part of the skin tissue was collected? Authors' response: As per the suggestion of the reviewer, we have elaborated on the procedure of skin tissue collection within the '' section in our methods. 2. Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. Authors' response: Our study maintained similar light intensities across control and shift simulation groups to focus on shift impacts, thereby reducing potential variation from light intensity differences. However, recognizing the significance of light intensity on chronic jet-lag, we will consider incorporating this factor into future experimental designs, perhaps by comparing the effects of different light intensities on chronic jet-lag. 3. More information should be provided on Circadian rhythm analysis, especially the setting of parameters. Authors' response: In response to the reviewer’s suggestion, we have clarified our use of the standard parameters of the Circapackage (as per Parsons et al. , Bioinformatics, 2020, PMID: 31588519). This approach includes a fixed period of 24 hours. 4. Why use two housekeeping genes in the same tissue for clock gene relative quantification? Authors' response: Vandesompele et al. (Genome Biol. 2002, PMID: 12184808) showed that normalizing with the geometric mean of carefully chosen control genes improves qPCR accuracy. Using a single universal control gene is less effective due to variations across different cells or tissues. [SEP] Justify:

Output: The text corroborates the claim as it discusses multiple studies indicating that bright light can affect circadian rhythms, activity, metabolism, and clock gene expression. Specifically, it notes that the impact of shift work light conditions on circadian rhythms has been studied, and acknowledges that light intensity affects chronic jet-lag, which relates directly to the misalignment of circadian rhythms caused by shift work.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: HomeBIJEthnobotany of medicinal plants used to treat malaria by traditional healers from ten indigenous colombian communities located in waupes medio Submit manuscript. . . eISSN: 2575-906X 167. DOI: 10. 15406/bij. 2017. 01. 00022 indigenous communities from possess knowledge in the use of plants to treat their illnesses. This knowledge has been transmitted orally from generation to generation. The present 3. 2billion people remain at risk of malaria. Annually, it produces between 149-303million clinical cases and kills more than 400,000 people. Among those killed, 90% are children under 5years old. 1 America, the transmission of paludism is found in nine countries sharing the amazon forest region and in 8 countries representing the Caribbean and Central America. 2 in 2016, 83 356 cases of malaria were reported to the Institute (INS) through the (Sivigila), and the distribution by species corresponded to 47 497 cases (57%) by P. falciparum, followed by P. vivax with 33 055 cases (39. 7%) and 2 804 cases (3. 3%) of mixed infections (P. falciparum and P. vivax). In addition, 19 deaths were confirmed because of this disease in Colombian territory. 3 These data show the importance of this disease in the panorama of morbidity and mortality at local and global level. Natural or vector borne infection in humans is by six species from the genus Plasmodium: P. falciparum, P. vivax, P. ovale, P. malariae, P. knowlesi,1 and recently P. cynomolgi. 4 This parasite is transmitted to humans by the bite of the Anopheles mosquito. Once inside the organism, the parasite causes clinical symptoms that can range from mild to grave, or even lead to fatal. 5,6 Traditional medicine uses plants to treat different illnesses, and their use is so efficient that the Organization (WHO) estimates that 80% of the world population uses plants as alternative therapy. 7 Since 1670, medical plants like Quina have been used to treat paludic feavers. It was not until 1820 that two French chemists, isolated a metabolite called quinina from this plant. [SEP] Justify:

Output: The text contrasts the claim by highlighting the use of plants in traditional medicine within indigenous communities, which implies that these plants are likely used for purposes beyond mere medicinal applications, possibly including ceremonial or spiritual practices. The statement that traditional medicine uses plants for various illnesses suggests a broader context where plants may play significant roles in cultural and spiritual contexts.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 Обновить, дополнить предоставленную информацию о персональных данных в случае изменения данной информации. 6. 1. 3 Пользователь имеет право отозвать согласие на обработку персональных данных, путем направления уведомления Оператору по адресу электронной почты: info@editorum. ru. 6. 2 Администрация сайта обязана: 6. 2. 1 Использовать полученную информацию исключительно для целей, указанных в п. 4 настоящей Политики конфиденциальности. 6. 2. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses user privacy rights and data processing instead of any information regarding sea turtles or their navigation methods.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Moreover, fluctuations within standard housekeeping genes depending on the time of day have been recognized in studies (Kosir et al. , BMC Mol Biol. 2010; PMID: 20712867). Thus, the utilization of more than one housekeeping gene minimizes this variability. 5. The author should discuss why Cry genes are preferentially altered under three light conditions. Authors' response: In the discussion section of the revised manuscript, we covered the response of Cry genes to simulated shift conditions. In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where the methods section should also provide detailed information. Please refer to the following comments for more details. 1. Describe in detail the process for collecting skin, which part of the skin tissue was collected? Authors' response: As per the suggestion of the reviewer, we have elaborated on the procedure of skin tissue collection within the '' section in our methods. 2. Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. Authors' response: Our study maintained similar light intensities across control and shift simulation groups to focus on shift impacts, thereby reducing potential variation from light intensity differences. However, recognizing the significance of light intensity on chronic jet-lag, we will consider incorporating this factor into future experimental designs, perhaps by comparing the effects of different light intensities on chronic jet-lag. 3. More information should be provided on Circadian rhythm analysis, especially the setting of parameters. Authors' response: In response to the reviewer’s suggestion, we have clarified our use of the standard parameters of the Circapackage (as per Parsons et al. , Bioinformatics, 2020, PMID: 31588519). This approach includes a fixed period of 24 hours. 4. Why use two housekeeping genes in the same tissue for clock gene relative quantification? Authors' response: Vandesompele et al. (Genome Biol. [SEP] Justify:

Output: The text corroborates the claim by discussing how shift work and light exposure can affect the circadian rhythms of canonical clock genes in the liver and skin of mice, specifically noting that 'shift-work light affects the circadian rhythms.' It refers to multiple studies that have shown direct effects of light on circadian rhythms, aligning with the notion that shift work can lead to health issues through disruption of these biological rhythms.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Quinina served as a template for the synthesis of the aminochinolines such as cloroquine, which was used as a first-line medicine until 1971 when the first cases of P. falciparum resistance appeared. 8 This stimulated the search for new antimalarial agents. In 1972 Chinese scientists isolated artemisinin from the Artemisa anua plant. This permitted the synthesis of the artemisinin derivatives artesunate, arteheter, artemether, constituting a new pilar of antimalarial therapy. 9,10 is a region both endemic to malaria and to some of the most diverse ecosystems in the world. One third of the worlds species are found in tropical rain forests. 11 Concurrenty, there exists a wide cultural diversity linked to traditional knowledge from different ethnic groups. This diversity has been affected and threatened by colonization which began in the 15th century and advanced in the 20th century. 12 In the case of Vaupes medio, it was due to the bonanaza of rubber, coca farming, and the sale of animal skins. These processes led to deforestation and an alteration in social structure, bringing about a loss of plant diversity and of the knowledge associated with it. 13 Among the indigenous and mestizo communities located in the of the southeastern part of Colombia, the population is 85% indigenous representing 27 ethnic groups. Among those groups, the most numerous are: Cubeo, Tucano, Desano and Guanano. 14 These communities are effected by malaria, above all, those which are located in the Vaupés Alto, Vaupés Medio, Papunahua, Apaporis river, and at the Querarí river head. In this zone, malaria has been treated by diverse traditional healers from the region using medicinal plants (for preventing it or curing it). Nevertheless, these practices are disappearing due to the social phenomena explained previously. The purpose of this study is to contribute to and preserve the ancestral knowledge related to medicinal use of plants among the communities located in the Vaupés Medio. More specifically, information was collected about medicinal plants used to cure malaria from 33 indigenous traditional healers from this zone. In the presence of the healers, plants were identified and collected. They were later studied taxonomically and the greater frequency of use was determined by the Friedman’s index. Materials and methods Study area An area of 10,901. [SEP] Justify:

Output: The text contrasts the claim by describing the use of medicinal plants by traditional healers in indigenous communities, which implies that these plants are not only used for therapeutic purposes but likely hold cultural, ceremonial, or spiritual significance as well. It specifically mentions that knowledge related to the medicinal use of plants among these communities is important to preserve, which suggests a broader context of plant usage beyond mere material utility.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 Обеспечить хранение конфиденциальной информации в тайне, не разглашать без предварительного письменного разрешения Пользователя, а также не осуществлять продажу, обмен, опубликование, либо разглашение иными возможными способами переданных персональных данных Пользователя, за исключением п. п. 5. 2. и 5. 3. настоящей Политики Конфиденциальности. 6. 2. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses confidentiality and privacy policies, which do not relate to sea turtles or their navigation methods.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: 2002, PMID: 12184808) showed that normalizing with the geometric mean of carefully chosen control genes improves qPCR accuracy. Using a single universal control gene is less effective due to variations across different cells or tissues. Moreover, fluctuations within standard housekeeping genes depending on the time of day have been recognized in studies (Kosir et al. , BMC Mol Biol. 2010; PMID: 20712867). Thus, the utilization of more than one housekeeping gene minimizes this variability. 5. The author should discuss why Cry genes are preferentially altered under three light conditions. Authors' response: In the discussion section of the revised manuscript, we covered the response of Cry genes to simulated shift conditions. Competing Interests: No conflicts of Report a concern Respond or 29 Aug 2023 of 29 Aug 2023 In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the. . . Continue reading In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where the methods section should also provide detailed information. Please refer to the following comments for more details. 1. Describe in detail the process for collecting skin, which part of the skin tissue was collected? Authors' response: As per the suggestion of the reviewer, we have elaborated on the procedure of skin tissue collection within the '' section in our methods. 2. Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. Authors' response: Our study maintained similar light intensities across control and shift simulation groups to focus on shift impacts, thereby reducing potential variation from light intensity differences. However, recognizing the significance of light intensity on chronic jet-lag, we will consider incorporating this factor into future experimental designs, perhaps by comparing the effects of different light intensities on chronic jet-lag. 3. [SEP] Justify:

Output: The text corroborates the claim by stating that 'shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice.' This indicates that shift work can disrupt the normal functioning of circadian rhythms, supporting the claim that such work can adversely affect health.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: During the presentation, it was highlighted the benefits and importance of recovering the oral knowledge of traditional antimalarial medicinal plants, and conserving it by recording it in the books. Once consent was obtained and the work consolidated with the communities, each community was visited in search of the key partners. In conclusion of the conciliation process, communities expressed their interest in the project and signed agreements between themselves and researchers of the University of Antioquia. The indigenous authorities recognized the project as an opportunity to gather and preserve the oral tradition of medicinal plants used to cure malaria. Ultimately, they desire to give ownership of this knowledge to the younger generations so that it is not lost over time. Traditional healer selection The key traditional healers were chosen according to participant observation. 17‒23 More specifically, the snowball or avalanche sampling approach was used,24 under the premise that the members of the population know each other and can identify which other person from the indigenous community to interview. Additionally, the following criteria were considered: living within the study area, to be recognized by their inhabitants as traditional healers, cure malaria with plants or prayers. In this context, 30 men and 3 women between the ages of 22 and 62 years old were chosen. Ethnobotanical survey Open interviews, semi-structured interviews and ethnobotanical walks were conducted with 33 traditional healers (31 indigenous and 2 belonging to a group of mestizos known as “cabuco”, according to the methodology described by Cunnigham. 25,19,26 They collected information about: Description and identification of plants used for treating malaria in their natural habitat Detailed description of each plant collection process (hour, station, place, among others) Part of the plant used (bark, root and leaf) and mode of preparation (infusion, decoction and etc. ) Recipe directions and warnings Overview of the illness (causes, diagnosis, prevention and treatments to cure and prevent it) During the walks, with each traditional healer, specimens following the described methodology (1. Thirty (91%) of the traditional healers are male. Eighteen (55%) of 33 performed surveys reported information from the ethnic Cubeo, and the rest from Carapana, Desano, Yuruti, Guanano and Mestizo groups. Among all the traditional healers, only one payé (shaman) from community was interviewed. [SEP] Justify:

Output: The text contrasts the claim by describing the significance of traditional healers who cure malaria with 'plants or prayers'. This indicates that plants studied in ethnobotany are indeed used for spiritual purposes, as it emphasizes the role of prayers alongside plant usage in the healing process.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 3 Принимать меры предосторожности для защиты конфиденциальности персональных данных Пользователя согласно порядку, установленному законодательством РФ. 6. 2. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses measures to protect user personal data according to Russian law and does not mention anything related to sea turtles or navigation.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: More information should be provided on Circadian rhythm analysis, especially the setting of parameters. Authors' response: In response to the reviewer’s suggestion, we have clarified our use of the standard parameters of the Circapackage (as per Parsons et al. , Bioinformatics, 2020, PMID: 31588519). This approach includes a fixed period of 24 hours. 4. Why use two housekeeping genes in the same tissue for clock gene relative quantification? Authors' response: Vandesompele et al. (Genome Biol. 2002, PMID: 12184808) showed that normalizing with the geometric mean of carefully chosen control genes improves qPCR accuracy. Using a single universal control gene is less effective due to variations across different cells or tissues. Moreover, fluctuations within standard housekeeping genes depending on the time of day have been recognized in studies (Kosir et al. , BMC Mol Biol. 2010; PMID: 20712867). Thus, the utilization of more than one housekeeping gene minimizes this variability. 5. The author should discuss why Cry genes are preferentially altered under three light conditions. Authors' response: In the discussion section of the revised manuscript, we covered the response of Cry genes to simulated shift conditions. In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where the methods section should also provide detailed information. Please refer to the following comments for more details. 1. Describe in detail the process for collecting skin, which part of the skin tissue was collected? Authors' response: As per the suggestion of the reviewer, we have elaborated on the procedure of skin tissue collection within the '' section in our methods. 2. Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. Authors' response: Our study maintained similar light intensities across control and shift simulation groups to focus on shift impacts, thereby reducing potential variation from light intensity differences. [SEP] Justify:

Output: The text corroborates the claim by discussing the impact of shift work light on circadian rhythms and referencing studies that indicate how bright light can influence the circadian rhythm of activity, metabolism, and clock gene expression. In particular, it notes that 'Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice,' which supports the notion that shift work can disrupt circadian rhythms and adversely affect health.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Description about the role of traditional healers within the middle vaupés indigenous communities The payé is a traditional healer and shaman from the Vaupés aboriginal societies that has magical powers and establishes a relationship with the supernatural world. He has knowledge about the community’s myths, treatments for illness and witchcraft practices. He is the master of a universe inhabited by spirits, and at the same time is a healer, protector of the community and exorcist. He reaches some level of trance to establish a connection with the supernatural universe in which one or more spirits are in his favor, hears his requests and assists him to practice good or evil. He is able to diagnose an illness, foresee the fate of the sick person and fight against witchcraft and other cultural ailments. Historically, in the Vaupés region the payé uses the aid of sacred plants like yage and yopo, to reach the psychological states of mind to communicate with the supernatural universe. 28 The payé is the community member who knows more about illnesses, the diagnosis and treatment techniques, and to some extent, the use of medicinal plants. Additionally, in some occasions, is the only person in charge of diagnosing, preventing and treating the illnesses of some communities which are beyond the reach of the state health programs. In addition to the payé, there are members in the community identified as traditional healers, they possess less knowledge than the payé, but also use plants to prevent and treat illness. However, they do not use sacred plants to reach a different psychological state of mind, nor are able to establish communication with the supernatural universe to be favored by the spirits. Reported species There were registered 41 morphospecies belonging to 37 genera, distributed in 25 families and locally labeled with 47 vernacular names (Table 2). Among the registered morphospecies 35 were identified down to species, 5 to genus, and one to family. The families with the larger number of genera and species were the Bignoniaceae (8 spices/7 genres) and Fabaceae (5 species/4 genres). The most frequent plant types for the antimalarial species were trees 19(46. 34 %), followed by vines 12(29. 26%), and in a less proportion, bushes 7(17. 07%), herbs 2(4. 87%) and palms 1(2. 43%), Table 2. [SEP] Justify:

Output: The text contrasts the claim by describing the use of sacred plants such as yage and yopo by traditional healers in the Vaupés region to establish communication with the supernatural universe, indicating that these plants are indeed used for ceremonial or spiritual purposes. It highlights that the payé, a traditional healer and shaman, utilizes these plants to reach psychological states necessary to interact with spirits, thus directly opposing the claim that plants in ethnobotany are never used for such purposes.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 4 Осуществить блокирование персональных данных, относящихся к соответствующему Пользователю, с момента обращения или запроса Пользователя или его законного представителя либо уполномоченного органа по защите прав субъектов персональных данных на период проверки, в случае выявления недостоверных персональных данных или неправомерных действий. 7. ОТВЕТСТВЕННОСТЬ СТОРОН 7. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses the blocking of personal data and responsibilities of parties, which does not relate to sea turtles or their navigation methods.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Molecular cancer biology, lung biology, immunology, circadian rhythms, metabolism I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. replyRespond to this report Responses (1) 29 Aug 2023 of “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver. In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. Authors' response: We appreciate the reviewer’s constructive and positive feedback on our manuscript. 1. This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. Authors' response: We thank the reviewer for highlighting this. We concur and have addressed the exclusive use of male mice in the limitations section, including potential differences in female outcomes. 2. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? [SEP] Justify:

Output: The text corroborates the claim by discussing a study that investigates the impact of shift work on circadian rhythms, particularly noting that long-term shift work and jet lag disrupt the oscillation characteristics of circadian genes. The findings indicate that different rotating work and sleep schedules can have significant impacts on molecular clock oscillation, supporting the idea that shift work affects health through circadian rhythm misalignment.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Among all 35 morphospecies identified down to the species, 31 are native to the region. The species Cosmos caudatus, Mangifera indica, Crescentia cujete and Citrus limon are introduced. 95. 12% of the species grow wild (38) and three (7. 31%) are cultivated. The part of the plant most commonly used by the traditional healers of the Middle Vaupés region to fabricate the medicine is the stem bark. Decoction with water was identified as the only procedure for preparing the medicine. The traditional healers described two ways for administering the medicine, oral, according to Pérez,29 and in baths and ointments for preventing the disease. Numbers of Number of 6. 1 Stem bark soothe toothaches and make axe handles. S6. 1 Stem bark Reed or reported. Pleonotoma variabilis (Jacq. ) Miers 194107 1 3 Stem bark Reed or reported. Callichlamys latifolia (Rich. ) K. Schum. 194120 1 3 Stem bark Reed or treat stomach ailments, epilepsy and poisoning by venom Crescentia cujete L. 1 3 Stem bark fruit is used to make totumas, a type of gourd used to make vessels for drinking or eating Jacaranda copaia (Aubl. ) D. Don subsp. spectabilis (Mart. ex DC. ) A. H. Gentry 194113 2 6. 1 Stem bark combat pruritis and skin infections Tabebuia serratifolia (Vahl) G. Nicholson 1 3 Stem bark cure rheumatism cf. glandifera Planch. & Triana 194125 4 12. 1 Stem bark, Not reported. spinescens (Hoffmanns. ex Vogel) H. S. Irwin & Barneby 194115 1 3 Stem bark Reed or reported. Cf. spruceana 194109 1 3 Stem bark reported. nervosa (Vahl) Boeckeler 1 3 Flower bud flu remedy dentatus (Aubl. ) Standl. 194111 1 3 or soo the headaches, fever and stomach pain. macrocarpa Ducke 194109 3 9. 1 Stem bark leaves of the tree are used for packaging farina (Amazon cereal). [SEP] Justify:

Output: The text contrasts the claim by detailing various plants used by traditional healers in the Middle Vaupés region for medicinal purposes, which implies their importance in cultural practices. The description of how parts of plants are utilized for concoctions and applications such as baths suggests that these plants could also hold ceremonial or spiritual significance, thus challenging the claim that they are never used in such contexts.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 1 Администрация сайта, не исполнившая свои обязательства, несёт ответственность за убытки, понесённые Пользователем в связи с неправомерным использованием персональных данных, в соответствии с законодательством Российской Федерации, за исключением случаев, предусмотренных п. п. 5. 2. , 5. 3. и 7. 2. настоящей Политики Конфиденциальности. 7. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses responsibilities related to the use of personal data and privacy policies under Russian law, which does not relate to sea turtles or their navigation methods.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: replyRespond to this report Responses (1) 29 Aug 2023 of this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where the methods section should also provide detailed information. Please refer to the following comments for more details. 1. Describe in detail the process for collecting skin, which part of the skin tissue was collected? Authors' response: As per the suggestion of the reviewer, we have elaborated on the procedure of skin tissue collection within the '' section in our methods. 2. Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. Authors' response: Our study maintained similar light intensities across control and shift simulation groups to focus on shift impacts, thereby reducing potential variation from light intensity differences. However, recognizing the significance of light intensity on chronic jet-lag, we will consider incorporating this factor into future experimental designs, perhaps by comparing the effects of different light intensities on chronic jet-lag. 3. More information should be provided on Circadian rhythm analysis, especially the setting of parameters. Authors' response: In response to the reviewer’s suggestion, we have clarified our use of the standard parameters of the Circapackage (as per Parsons et al. , Bioinformatics, 2020, PMID: 31588519). This approach includes a fixed period of 24 hours. 4. Why use two housekeeping genes in the same tissue for clock gene relative quantification? Authors' response: Vandesompele et al. (Genome Biol. 2002, PMID: 12184808) showed that normalizing with the geometric mean of carefully chosen control genes improves qPCR accuracy. Using a single universal control gene is less effective due to variations across different cells or tissues. Moreover, fluctuations within standard housekeeping genes depending on the time of day have been recognized in studies (Kosir et al. , BMC Mol Biol. 2010; PMID: 20712867). [SEP] Justify:

Output: The text corroborates the claim by indicating that shift work affects the circadian rhythms of canonical clock genes, as mentioned in the report on multiple studies which suggest that bright light impacts the circadian rhythm of activity and metabolism. This aligns with the claim that shift work can adversely affect health, as misalignment of circadian rhythms due to environmental factors such as light is a significant influencing factor.


Input: Task: contrast the claim using the given text. Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: The stem bark is applied to the skin to alleviate itchiness and as a deodorant Machaerium sp 1 3 or the Cubeos, it is used to treat stomachaches and headaches. Monopteryx uaucu Spruce ex. Benth. 1 3 Stem bark reported Myroxylon balsamum (L. ) Harms 1 3 Stem bark reported Fabaceae pagapunisuore 194133 1 3 Stem bark calm headache, fever and stomach pain. brasiliensis Kosterm. 194122 1 3 Stem bark fruit is used against snakebites. resinifera Mart. 194119 2 6. 1 Stem bark snake bites and to reduce fever japurensis A. Juss. 1 3 Stem bark fruit of the plant is used as bate for fishing 194135 1 3 Stem bark Reed or reported. guidonia (L. ) Sleumer 194112 1 3 Stem bark soo the stomach pains, diarrhea and as a purgative. grandifolia (Mart. ) Sandwith 194130 9 27. 2 Stem bark, to treat snake bites, to prevent and treat whooping cough and a pain killer for headaches. It is also used as an emetic to maintain youth and gain strength. Historically, the Cubeos used it to make hunting arrows due to its tough stem Abuta rufescens Aubl. 194121 1 3 or cure fever, and treat headache and rheumatism. 194132 2 6. 1 or treat diarrhea and common illnesses (e. g. vomiting, headache, fever). laeta (Benth. ) Barneby & J. W. Grimes 194124 1 3 Stem bark a purgative and to soothe stomach pains. Inga umbellifera (Vahl) Steud. 194110 2 6. 1 Stem bark other diseases which manifest fever and headache. decorticans Ducke 194117 1 3 Stem bark reported. cf. duplipilosa McVaugh 194129 1 3 Stem bark cure diarrhea Psidium cf acutangulum Mart. ex DC 94128 1 3 Stem bark leaves are used to package farina and the stem bark to relieve skin irritations and as a body deodorant flava 194216 1 9 or soothe stomach pains and treat diarrhea cornifolia (Kunth) Standl. [SEP] Justify:

Output: The text contrasts the claim by detailing various medicinal uses of plant components, such as the stem bark for treating ailments like stomachaches and headaches, as well as its historical use for making hunting arrows. This suggests that these plants have ceremonial significance linked to their application in traditional practices, contradicting the claim that these plants are never used for ceremonial or spiritual purposes.


Input: Task: pass the claim using the given text. Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 В случае утраты или разглашения персональных данных Администрация сайта не несёт ответственность, если данные персональные данные: 7. 2. 1 Стали публичным достоянием до их утраты или разглашения. 7. 2. 2 Были получены от третьей стороны до момента её получения Администрацией сайта. 7. 2. 3 Были разглашены с согласия Пользователя. 8. РАЗРЕШЕНИЕ СПОРОВ 8. [SEP] Justify:

Output: The text is irrelevant to the claim as it discusses issues related to personal data disclosure and dispute resolution, without any mention of sea turtles or their navigation methods.


Input: Task: corroborate the claim using the given text. Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: To investigate the impact of shift-work light conditions on circadian rhythms of canonical clock genes, a group of C57BL/6J male mice were randomly assigned and housed (3 mice per cage) in a controlled environment that simulated shift-work light conditions. The mice were subjected to different simulated conditions: either short-term (15 days) or long-term (45 days) rotating shifts, where the light conditions changed every seventh day, or a jet-lag condition lasting 21 days with an 8-hour phase advance every two days. As a comparison, a control group of mice followed the standard light-dark cycle of the facility (Figure 1). A total of 72 mice were included in this study, to cover 24 timepoints across 4 light conditions. An n = 3 was chosen per time point as the minimum number required to identify statistical differences per time-point, which translates to n = 18 per experimental condition for circadian analyses. Following exposure to simulated light conditions with an intensity of ~590 lux, the mice were housed in constant dark for up to 48 hours. On the second day, mice were sacrificed at the age of 11 to 12 weeks old, and samples of liver and skin tissues were collected from three mice at each time point over a 24-hour period, with four-hour intervals (Figure 1). Specifically, whole skin tissue was collected from dorsal lateral side of the mouse following post-cervical dislocation, placed on fixed card stock, covered with foil, snap-frozen, and stored at -80 °C for RNA extraction. To manipulate the light conditions, the mice were housed in light-tight circadian chambers provided by Phenome Technologies, Inc. The light schedules were regulated by an external timer (XT-4, Chrontrol Corporation), and the light status and intensity were monitored using HOBO data loggers (UA-002-08, Corporation). All mice, regardless of the light conditions or constant darkness, were given ad libitum feeding. Throughout the time-course sample collection, red light was utilized, and animals were killed per housed group, where one cage of 3 mice represented one time-point. This was done to limit variability in any time-point. Mice were anesthetized with 3-4% isoflurane and euthanized by cardiac puncture blood collection followed by cervical dislocation as a secondary method of euthanasia. [SEP] Justify:

Output: The text corroborates the claim by describing an investigation into the impact of shift-work light conditions on circadian rhythms. It discusses how the mice were subjected to various light conditions simulating shift work, suggesting the potential for such conditions to affect the body's internal clock and emphasizing the importance of light exposure on circadian rhythms.