Title: Self-supervised Graph-level Representation Learning with Local and Global Structure. Abstract: This paper focuses on unsupervised/self-supervised whole-graph representation learning, which is critical in many tasks including drug and material discovery. Current methods can effectively model the local structure between different graph instances, but they fail to discover the global semantic structure of the entire dataset. In this work, we propose a unified framework called Local-instance and Global-semantic Learning (GraphLoG) for self-supervised whole-graph representation learning. Specifically, besides preserving the local instance-level structure, GraphLoG leverages a nonparametric strategy to learn hierarchical prototypes of the data. These prototypes capture the semantic clusters in the latent space, and the number of prototypes can automatically adapt to different feature distributions. We evaluate GraphLoG by pre-training it on massive unlabeled graphs followed by fine-tuning on downstream tasks. Extensive experiments on both chemical and biological benchmark datasets demonstrate the effectiveness of our approach. 