Title: A Simple Unified Information Regularization Framework for Multi-Source Domain Adaptation. Abstract: Adversarial learning strategy has demonstrated remarkable performance in dealing with single-source unsupervised Domain Adaptation (DA) problems, and it has recently been applied to multi-source DA problems. While most of the existing DA methods use multiple domain discriminators, the effect of using multiple discriminators on the quality of latent space representations has been poorly understood. Here we provide theoretical insights into potential pitfalls of using multiple domain discriminators: First, domain-discriminative information is inevitably distributed across multiple discriminators. Second, it is not scalable in terms of computational resources. Third, the variance of stochastic gradients from multiple discriminators may increase, which significantly undermines training stability. To fully address these issues, we situate adversarial DA in the context of information regularization. First, we present a unified information regularization framework for multi-source DA. It provides a theoretical justification for using a single and unified domain discriminator to encourage the synergistic integration of the information gleaned from each domain. Second, this motivates us to implement a novel neural architecture called a Multi-source Information-regularized Adaptation Networks (MIAN). The proposed model significantly reduces the variance of stochastic gradients and increases computational-efficiency. Large-scale simulations on various multi-source DA scenarios demonstrate that MIAN, despite its structural simplicity, reliably outperforms other state-of-the-art methods by a large margin especially for difficult target domains.