Title: When in Doubt, Summon the Titans: A Framework for Efficient Inference with Large Models. Abstract: Scaling neural networks to "large" sizes, with billions of parameters, has been shown to yield impressive results on many challenging problems. However, the inference cost incurred by such large models often prevent their application in most real-world settings. In this paper, we propose a two-stage framework based on distillation that realizes the modelling benefits of the large models, while largely preserving the computational benefits of inference with more lightweight models. In a nutshell, we use the large teacher models to guide the lightweight student models to only make correct predictions on a subset of "easy" examples; for the "hard" examples, we fall-back to the teacher. Such an approach allows us to efficiently employ large models in practical scenarios where easy examples are much more frequent than rare hard examples. Our proposed use of distillation to only handle easy instances allows for a more aggressive trade-off in the student size, thereby reducing the amortized cost of inference and achieving better accuracy than standard distillation. Empirically, we demonstrate the benefits of our approach on both image classification and natural language processing benchmarks.