Title: Data-driven Feature Sampling for Deep Hyperspectral Classification and Segmentation. Abstract: The high dimensionality of hyperspectral imaging forces unique challenges in scope, size and processing requirements.  Motivated by the potential for an in-the-field cell sorting detector, we examine a Synechocystis sp. PCC 6803 dataset wherein cells are grown alternatively in nitrogen rich or deplete cultures.  We use deep learning techniques to both successfully classify cells and generate a mask segmenting the cells/condition from the background. Further, we use the classification accuracy to guide a data-driven, iterative feature selection method, allowing the design neural networks requiring 90% fewer input features with little accuracy degradation.