Certain highly toxic chemicals will be banned unless exposure to them would in practice be negligible, namely those which are carcinogenic, mutagenic or toxic to reproduction, those which are endocrine-disrupting, and those which are persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB).
Vairākas toksiskas vielas, proti, vielas, kas kaitē reproduktīvajai veselībai vai var veicināt vēža saslimšanas, būs aizliegtas, izņemot gadījumus, ja šo vielu ietekme nav būtiska.