On 14 November 2001, a declaration was adopted at Doha, during the WTO ministerial conference, to make the application of TRIPS more flexible not only for developing countries without the manufacturing capability but also for exporting countries.
Regulas pamatu veido daudzpusējās (PTO) sarunās panākts līdzsvars, tāpēc Eiropas Savienības rīcības brīvība nav plaša.