Hepatitis c virus inhibitorsHepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.A compound or pharmaceutically acceptable salt thereof, described compound is selected from:((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-14a-(((1-(methyl fluoride) cyclopropyl) alkylsulfonyl) carbamyl)-2-((3-(4-isopropyl phenyl)-6-methoxyisoquinoliae-1-base) oxygen base)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third also [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base) carboxylamine (s)-3-(trifluoromethyl) tetrahydrochysene-2h-pyrans-3-base ester;((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-14a-(((1-(methyl fluoride) cyclopropyl) alkylsulfonyl) carbamyl)-2-((3-(4-isopropyl phenyl)-6-methoxyisoquinoliae-1-base) oxygen base)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third also [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base) carboxylamine (r)-3-(trifluoromethyl) tetrahydrochysene-2h-pyrans-3-base ester;((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-2-((the fluoro-6-methoxyisoquinoliae of 7--1-base) oxygen base)-14a-(((1-(methyl fluoride) cyclopropyl) alkylsulfonyl) carbamyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third is [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base also) carboxylamine 1, the fluoro-2-methyl-prop of 1,1-tri--2-base ester;((2r, 6s, 7r, 9s, 13as, 14ar, 16as, z)-2-((the fluoro-6-methoxyisoquinoliae of 7--1-base) oxygen base)-14a-(((1-(methyl fluoride) cyclopropyl) alkylsulfonyl) carbamyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third is [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base also) carboxylamine 1, the fluoro-2-methyl-prop of 1,1-tri--2-base ester;((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-7-ethyl-2-((fluoro-3, the 6-dimethoxy-isoquinoline-1-bases of 7-) oxygen base)-9-methyl isophthalic acid 4a-(((1-methylcyclopropyl groups) alkylsulfonyl) carbamyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third is [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base also) carboxylamine 1, the fluoro-2-methyl-prop of 1,1-tri--2-base ester;((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-7-ethyl-2-((fluoro-3, the 6-dimethoxy-isoquinoline-1-bases of 7-) oxygen base)-9-methyl isophthalic acid 4a-(((1-methylcyclopropyl groups) alkylsulfonyl) carbamyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third also [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base) the fluoro-2-methyl fourth of carboxylamine 3,3-bis--2-base ester;((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-7-ethyl-2-((fluoro-3, the 6-dimethoxy-isoquinoline-1-bases of 7-) oxygen base)-9-methyl isophthalic acid 4a-(((1-methylcyclopropyl groups) alkylsulfonyl) carbamyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third also [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base) carboxylamine 3-(trifluoromethyl) tetrahydrochysene-2h-pyrans-3-base ester;((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-2-((the fluoro-6-methoxyisoquinoliae of 7--1-base) oxygen base)-14a-(((1-(methyl fluoride) cyclopropyl) alkylsulfonyl) carbamyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third also [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base) carboxylamine 2-(trifluoromethyl) tetrahydrochysene-2h-pyrans-2-base ester;((2r, 6s, 7r, 9s, 13as, 14ar, 16as, z)-2-((the fluoro-6-methoxyisoquinoliae of 7--1-base) oxygen base)-14a-(((1-(methyl fluoride) cyclopropyl) alkylsulfonyl) carbamyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third also [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base) carboxylamine 2-(trifluoromethyl) tetrahydrochysene-2h-pyrans-2-base ester;((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-7-ethyl-2-((the fluoro-6-methoxyisoquinoliae of 7--1-base) oxygen base)-9-methyl isophthalic acid 4a-(((1-methylcyclopropyl groups) alkylsulfonyl) carbamyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third is [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base also) carboxylamine 2-(trifluoromethyl) tetrahydrochysene-2h-pyrans-2-base ester;((2r, 6s, 7r, 9r, 13as, 14ar, 16as, z)-2-((3,6-dimethoxy-isoquinoline-1-base) oxygen base)-7-ethyl-14a-(((1-(methyl fluoride) cyclopropyl) alkylsulfonyl) carbamyl)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third is [e] pyrrolo-[1,2-a] [isosorbide-5-nitrae] diaza cyclopentadecylene-6-base also) carboxylamine 1, the fluoro-2-methyl-prop of 1,1-tri--2-base ester;((2r, 6s, 7r, 9s, 13as, 14ar, 16as, z)-2-((3,6-dimethoxy-isoquinoline-1-base) oxygen base)-7-ethyl-14a-(((1-(methyl fluoride) cyclopropyl) alkylsulfonyl) carbamyl)-9-methyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-16 hydrogen ring third is [e] pyrrolo-[1,2-a...
C형 간염 바이러스 억제제하기 화학식 I을 갖는 C형 간염 바이러스 억제제가 개시되어 있다. 하기 화합물을 포함하는 조성물, 및 하기 화합물을 사용하여 HCV를 억제하는 방법이 또한 개시되어 있다. <화학식 I>(S)-3-(트리플루오로메틸)테트라히드로-2H-피란-3-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1-(플루오로메틸)시클로프로필)술포닐)카르바모일)-2-((3-(4-이소프로폭시페닐)-6-메톡시이소퀴놀린-1-일)옥시)-7,9-디메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;(R)-3-(트리플루오로메틸)테트라히드로-2H-피란-3-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((1-(플루오로메틸)시클로프로필)술포닐)카르바모일)-2-((3-(4-이소프로폭시페닐)-6-메톡시이소퀴놀린-1-일)옥시)-7,9-디메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-플루오로-6-메톡시이소퀴놀린-1-일)옥시)-14a-(((1-(플루오로메틸)시클로프로필)술포닐)카르바모일)-7,9-디메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-플루오로-6-메톡시이소퀴놀린-1-일)옥시)-14a-(((1-(플루오로메틸)시클로프로필)술포닐)카르바모일)-7,9-디메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-에틸-2-((7-플루오로-3,6-디메톡시이소퀴놀린-1-일)옥시)-9-메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;3,3-디플루오로-2-메틸부탄-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-에틸-2-((7-플루오로-3,6-디메톡시이소퀴놀린-1-일)옥시)-9-메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;3-(트리플루오로메틸)테트라히드로-2H-피란-3-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-에틸-2-((7-플루오로-3,6-디메톡시이소퀴놀린-1-일)옥시)-9-메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;2-(트리플루오로메틸)테트라히드로-2H-피란-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-플루오로-6-메톡시이소퀴놀린-1-일)옥시)-14a-(((1-(플루오로메틸)시클로프로필)술포닐)카르바모일)-7,9-디메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;2-(트리플루오로메틸)테트라히드로-2H-피란-2-일 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-플루오로-6-메톡시이소퀴놀린-1-일)옥시)-14a-(((1-(플루오로메틸)시클로프로필)술포닐)카르바모일)-7,9-디메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;2-(트리플루오로메틸)테트라히드로-2H-피란-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-에틸-2-((7-플루오로-6-메톡시이소퀴놀린-1-일)옥시)-9-메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,6-디메톡시이소퀴놀린-1-일)옥시)-7-에틸-14a-(((1-(플루오로메틸)시클로프로필)술포닐)카르바모일)-9-메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-디메톡시이소퀴놀린-1-일)옥시)-7-에틸-14a-(((1-(플루오로메틸)시클로프로필)술포닐)카르바모일)-9-메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((시클로프로필술포닐)카르바모일)-7-에틸-2-((8-플루오로-9-메톡시-2,3-디히드로-1H-피라노[2,3-c]이소퀴놀린-6-일)옥시)-9-메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((8-플루오로-9-메톡시-2,3-디히드로-1H-피라노[2,3-c]이소퀴놀린-6-일)옥시)-7,9-디메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-에틸-2-((8-플루오로-9-메톡시-2,3-디히드로-1H-피라노[2,3-c]이소퀴놀린-6-일)옥시)-9-메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;3,3-디플루오로-2-메틸부탄-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-에틸-2-((8-플루오로-9-메톡시-2,3-디히드로-1H-피라노[2,3-c]이소퀴놀린-6-일)옥시)-9-메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-에틸-2-((6-플루오로-2,7-디메톡시퀴놀린-4-일)옥시)-9-메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;3,3-디플루오로-2-메틸부탄-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-에틸-2-((6-플루오로-2,7-디메톡시퀴놀린-4-일)옥시)-9-메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((시클로프로필술포닐)카르바모일)-7-에틸-2-((6-플루오로-2,7-디메톡시퀴놀린-4-일)옥시)-9-메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;3,3-디플루오로-2-메틸부탄-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((시클로프로필술포닐)카르바모일)-7-에틸-2-((6-플루오로-2,7-디메톡시퀴놀린-4-일)옥시)-9-메틸-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;1,1,1-트리플루오로-2-메틸프로판-2-일 ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-플루오로-2,7-디메톡시퀴놀린-4-일)옥시)-7,9-디메틸-14a-(((1-메틸시클로프로필)술포닐)카르바모일)-5,16-디옥소-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-헥사데카히드로시클로프로파[e]피롤로[1,2-a][1,4]디아자시클로펜타데신-6-일)카르바메이트;3,3-디...