PYRROLO [1,2-B]PYRIDAZINE DERIVATIVESProvided is a compound of Formula (I), wherein the variable groups are defined herein.A compound of (I)wherein:R1 and R2 are each independently selected from:a) Ci-io alkyl optionally substituted with Z ;b) C3-10 cycloalkyl optionally substituted with Z1;c) 5-10 membered heteroaryl optionally substituted with Z1;d) C6-io aryl optionally substituted with Z1;e) 4-7 membered monocyclic heterocyclyl optionally substituted with Z1 ; f) 6-12 membered bicyclic heterocyclyl optionally substituted with Z1; or g) -N(R12)( R ), -S(0)2R12, -S(0)2N(R12)( R ), or -H;R3 and R4 are each independently selected from:a) H, halo, -N02, -CN, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)(R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), -N(R12)C(0)- N(R12)( R12), -S(0)2R12 or -S(0)2N(R12)( R12);b) Ci-9 alkyl optionally substituted with Z1;c) C2_9 alkynyl optionally substituted with Z1;d) C2_9 alkenyl optionally substituted with Z1;e) 5-10 membered heteroaryl optionally substituted with Z1;f) C6-io aryl optionally substituted with Z1;g) 4-12 membered heterocyclyl optionally substituted with Z1; orh) C3-10 cycloalkyl optionally substituted with Z1;R5, R6 and R7 are each independently selected from: a) H, halo, -N02, -CN, -O-R , -C(0)-R , -C(0)-N(R1Z)( R1Z), -N(R1Z)( R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, or -N(R12)S(0)2(R12; b) Ci-5 alkyl optionally substituted with Z1 ; orc) Cyclopropyl, oxetanyl or azetidinyl optionally substituted with Z1 ;Z1 is independently oxo, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0- R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0- R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S- R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla; each Zla is independently oxo, halo, -NO2, -CN, -N3, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12or -S(0)2N(R12)( R12);wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zlb; each R12 is independently H, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl or heterocyclyl;wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla; each Zlb is independently oxo, hydroxy, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(Ci_9 alkyl), -0(C2-6 alkenyl), -0(C2-6 alkynyl), -0(C3-i5 cycloalkyl), -0(Ci_8 haloalkyl), - O(aryl), -O(heteroaryl), -O(heterocyclyl), -NH2, -NH(Ci_9 alkyl), -NH(C2-6alkenyl), -NH(C2-6 alkynyl), -NH(C3-15 cycloalkyl), -NH(Ci_8 haloalkyl), -NH(aryl), - NH(heteroaryl), -NH(heterocyclyl), -N(C1-9 alkyl)2, -N(C3-15 cycloalkyl)2, -N(C2-6 alkenyl)2, -N(C2-6 alkynyl)2, -N(C3-i5 cycloalkyl)2, -N(Ci-8 haloalkyl)2, -N(aryl)2, - N(heteroaryl)2, -N(heterocyclyl)2, -N(Ci-9 alkyl)(C3_i5 cycloalkyl), -N(Ci-9 alkyl)(C2_6 alkenyl), -N(C1-9 alkyl)(C2_6 alkynyl), -N(C1-9 alkyl)(C3_i5 cycloalkyl), -N(C1-9 alkyl)(C1-8 haloalkyl), -N(C1-9 alkyl)(aryl), -N(C1-9 alkyl)(heteroaryl), -N(C1-9alkyl)(heterocyclyl), -C(0)(C1-9 alkyl), -C(0)(C2_6 alkenyl), -C(0)(C2_6alkynyl), -C(0)(C3-15 cycloalkyl), -C(0)(C1-8 haloalkyl), -C(0)(aryl), -C(0)(heteroaryl), -C(0)(heterocyclyl), -C(0)0(C1-9 alkyl), -C(0)0(C2_6 alkenyl), -C(0)0(C2_6alkynyl), -C(0)0(C3_i5 cycloalkyl), -C(0)0(C1-8 haloalkyl), -C(0)0(aryl), - C(0)0(heteroaryl), -C(0)0(heterocyclyl), -C(0)NH2, -C(0)NH(Ci_9alkyl), -C(0)NH(C2_6 alkenyl), -C(0)NH(C2_6 alkynyl), -C(0)NH(C3_i5cycloalkyl), -C(0)NH(Ci_8 haloalkyl), -C(0)NH(aryl), -C(0)NH(heteroaryl), - C(0)NH(heterocyclyl), -C(0)N(C1-9 alkyl)2, -C(0)N(C3_i5 cycloalkyl)2, -C(0)N(C2_6 alkenyl)2, -C(0)N(C2.6 alkynyl)2, -C(0)N(C3_15 cycloalkyl),, -C(0)N(C1.8 haloalkyl)2, - C(0)N(aryl)2, -C(0)N(heteroaryl)2, -C(0)N(heterocyclyl)2, -NHC(0)(Ci_9alkyl), -NHC(0)(C2_6 alkenyl), -NHC(0)(C2_6 alkynyl), -NHC(0)(C3_i5cycloalkyl), -NHC(0)(d_8 haloalkyl), -NHC(0)(aryl), -NHC(0)(heteroaryl), - NHC(0)(heterocyclyl), -NHC(0)0(Ci_9 alkyl), -NHC(0)0(C2_6 alkenyl), -NHC(0)0(C2_ 6 alkynyl), -NHC(0)0(C3_i5 cycloalkyl), -NHC(0)0(Ci_8 haloalkyl), -NHC(0)0(aryl), - NHC(0)0(heteroaryl), -NHC(0)0(heterocyclyl), -NHC(0)NH(Ci_9alkyl), -NHC(0)NH(C2_6 alkenyl), -NHC(0)NH(C2_6 alkynyl), -NHC(0)NH(C3_i5 cycloalkyl), -NHC(0)NH(Ci_8 haloalkyl), -NHC(0)NH(aryl), - NHC(0)NH(heteroaryl), -NHC(0)NH(heterocyclyl), -SH, -S(C1-9...
피롤로[1,2-b]피리딘 유도체화학식 (I)의 화합물이 제공되며, 여기서 가변기는 본원에 정의되어 있다.화학식 (I)의 화합물 또는 그의 제약상 허용되는 염, 입체이성질체, 입체이성질체의 혼합물 또는 중수소화 유사체.여기서R1 및 R2는 각각 독립적으로 하기로부터 선택되고:a) Z1로 임의로 치환된 C1-10 알킬;b) Z1로 임의로 치환된 C3-10 시클로알킬;c) Z1로 임의로 치환된 5-10원 헤테로아릴;d) Z1로 임의로 치환된 C6-10 아릴;e) Z1로 임의로 치환된 4-7원 모노시클릭 헤테로시클릴;f) Z1로 임의로 치환된 6-12원 비시클릭 헤테로시클릴; 또는g) -N(R12)(R12), -S(O)2R12, -S(O)2N(R12)(R12), 또는 -H;R3 및 R4는 각각 독립적으로 하기로부터 선택되고:a) H, 할로, -NO2, -CN, -O-R12, -C(O)-R12, -C(O)-N(R12)(R12), -N(R12)(R12), -N(R12)C(O)-R12, -N(R12)C(O)O-R12, -N(R12)S(O)2(R12), -N(R12)C(O)-N(R12)(R12), -S(O)2R12 또는 -S(O)2N(R12)(R12);b) Z1로 임의로 치환된 C1-9 알킬;c) Z1로 임의로 치환된 C2-9 알키닐;d) Z1로 임의로 치환된 C2-9 알케닐;e) Z1로 임의로 치환된 5-10원 헤테로아릴;f) Z1로 임의로 치환된 C6-10 아릴;g) Z1로 임의로 치환된 4-12원 헤테로시클릴; 또는h) Z1로 임의로 치환된 C3-10 시클로알킬;R5, R6 및 R7은 각각 독립적으로 하기로부터 선택되고:a) H, 할로, -NO2, -CN, -O-R12, -C(O)-R12, -C(O)-N(R12)(R12), -N(R12)(R12), -N(R12)C(O)-R12, -N(R12)C(O)O-R12, 또는 -N(R12)S(O)2(R12);b) Z1로 임의로 치환된 C1-5 알킬; 또는c) Z1로 임의로 치환된 시클로프로필, 옥세타닐 또는 아제티디닐;Z1은 독립적으로 옥소, 할로, -NO2, -N3, -CN, C1-9 알킬, C2-6 알케닐, C2-6 알키닐, C3-15 시클로알킬, C1-8 할로알킬, 아릴, 헤테로아릴, 헤테로시클릴, -O-R12, -C(O)-R12, -C(O)O-R12, -C(O)-N(R12)(R12), -N(R12)(R12), -N(R12)2(R12)+, -N(R12)C(O)-R12, -N(R12)C(O)O-R12, -N(R12)C(O)N(R12)(R12), -N(R12)S(O)2(R12), -NR12S(O)2N(R12)(R12), -NR12S(O)2O(R12), -OC(O)R12, -OC(O)OR12, -OC(O)-N(R12)(R12), -Si(R12)3, -S-R12, -S(O)R12, -S(O)(NH)R12, -S(O)2R12 또는 -S(O)2N(R12)(R12)이고;여기서 임의의 알킬, 알케닐, 알키닐, 시클로알킬, 할로알킬, 아릴, 헤테로아릴 또는 헤테로시클릴은 Z1a로 임의로 치환되고;각각의 Z1a는 독립적으로 옥소, 할로, -NO2, -CN, -N3, C1-9 알킬, C2-6 알케닐, C2-6 알키닐, C3-15 시클로알킬, C1-8 할로알킬, 아릴, 헤테로아릴, 헤테로시클릴, -O-R12, -C(O)R12, -C(O)O-R12, -C(O)N(R12)(R12), -N(R12)(R12), -N(R12)2(R12)+, -N(R12)-C(O)R12, -N(R12)C(O)O(R12), -N(R12)C(O)N(R12)(R12), -N(R12)S(O)2(R12), -N(R12)S(O)2-N(R12)(R12), -N(R12)S(O)2O(R12), -OC(O)R12, -OC(O)OR12, -OC(O)-N(R12)(R12), -Si(R12)3, -S-R12, -S(O)R12, -S(O)(NH)R12, -S(O)2R12 또는 -S(O)2N(R12)(R12)이고;여기서 임의의 알킬, 알케닐, 알키닐, 시클로알킬, 할로알킬, 아릴, 헤테로아릴 또는 헤테로시클릴은 Z1b로 임의로 치환되고;각각의 R12는 독립적으로 H, C1-9 알킬, C2-6 알케닐, C2-6 알키닐, C3-15 시클로알킬, 아릴, 헤테로아릴 또는 헤테로시클릴이고;여기서 임의의 알킬, 알케닐, 알키닐, 시클로알킬, 아릴, 헤테로아릴 또는 헤테로시클릴은 Z1a로 임의로 치환되고;각각의 Z1b는 독립적으로 옥소, 히드록시, 할로, -NO2, -N3, -CN, C1-9 알킬, C2-6 알케닐, C2-6 알키닐, C3-15 시클로알킬, C1-8 할로알킬, 아릴, 헤테로아릴, 헤테로시클릴, -O(C1-9 알킬), -O(C2-6 알케닐), -O(C2-6 알키닐), -O(C3-15 시클로알킬), -O(C1-8 할로알킬), -O(아릴), -O(헤테로아릴), -O(헤테로시클릴), -NH2, -NH(C1-9 알킬), -NH(C2-6 알케닐), -NH(C2-6 알키닐), -NH(C3-15 시클로알킬), -NH(C1-8 할로알킬), -NH(아릴), -NH(헤테로아릴), -NH(헤테로시클릴), -N(C1-9 알킬)2, -N(C3-15 시클로알킬)2, -N(C2-6 알케닐)2, -N(C2-6 알키닐)2, -N(C3-15 시클로알킬)2, -N(C1-8 할로알킬)2, -N(아릴)2, -N(헤테로아릴)2, -N(헤테로시클릴)2, -N(C1-9 알킬)(C3-15 시클로알킬), -N(C1-9 알킬)(C2-6 알케닐), -N(C1-9 알킬)(C2-6 알키닐), -N(C1-9 알킬)(C3-15 시클로알킬), -N(C1-9 알킬)(C1-8 할로알킬), -N(C1-9 알킬)(아릴), -N(C1-9 알킬)(헤테로아릴), -N(C1-9 알킬)(헤테로시클릴), -C(O)(C1-9 알킬), -C(O)(C2-6 알케닐), -C(O)(C2-6 알키닐), -C(O)(C3-15 시클로알킬), -C(O)(C1-8 할로알킬), -C(O)(아릴), -C(O)(헤테로아릴), -C(O)(헤테로시클릴), -C(O)O(C1-9 알킬), -C(O)O(C2-6 알케닐), -C(O)O(C2-6 알키닐), -C(O)O(C3-15 시클로알킬), -C(O)O(C1-8 할로알킬), -C(O)O(아릴), -C(O)O(헤테로아릴), -C(O)O(헤테로시클릴), -C(O)NH2, -C(O)NH(C1-9 알킬), -C(O)NH(C2-6 알케닐), -C(O)NH(C2-6 알키닐), -C(O)NH(C3-15 시클로알킬), -C(O)NH(C1-8 할로알킬), -C(O)NH(아릴), -C(O)NH(헤테로아릴), -C(O)NH(헤테로시클릴), -C(O)N(C1-9 알킬)2, -C(O)N(C3-15 시클로알킬)2, -C(O)N(C2-6 알케닐)2, -C(O)N(C2-6 알키닐)2, -C(O)N(C3-15 시클로알킬)2, -C(O)N(C1-8 할로알킬)2, -C(O)N(아릴)2, -C(O)N(헤테로아릴)2, -C(O)N(헤테로시클릴)2, -NHC(O)(C1-9 알킬), -NHC(O)(C2-6 알케닐), -NHC(O)(C2-6 알키닐), -NHC(O)(C3-15 시클로알킬), -NHC(O)(C1-8 할로알킬), -NHC(O)(아릴), -NHC(O)(헤테로아릴), -NHC(O)(헤테로시클릴), -NHC(O)O(C1-9 알킬), -NHC(O)O(C2-6 알케닐), -NHC(O)O(C2-6 알키닐), -NHC(O)O(C3-15 시클로알킬), -NHC(O)O(C1-8 할로알킬), -NHC(O)O(아릴), -NHC(O)O(헤테로아릴), -NHC(O)O(헤테로시클릴), -NHC(O)NH(C1-9 알킬), -NHC(O)NH(C2-6 알케닐), -NHC(O)NH(C2-6 알키닐), -NHC(O)NH(C3-15 시클로알킬), -NHC(O)NH(C1-8 할로알킬), -NHC(O)NH(아릴), -NHC(O)NH(헤테로아릴), -NHC(O)NH(헤테로시클릴), -SH, -S(C1-9 알킬), -S(C2-6 알케닐), -S(C2-6 알키닐), -S(C3-15 시클로알킬), -S(C1-8 할로알킬), -S(아릴), -S(헤테로아릴), -S(헤테로시클릴), -NHS(O)(C1-9 알킬), -N(C1-9 알킬)(S(O)(C1-9 알킬), -S(O)N(C1-9 알킬)2, -S(O)(C1-9 알킬), -S(O)(NH)(C1-9 알킬), -S(O)(C2-6 알케닐), -S(O)(C2-6 알키닐), -S(O)(C3-15 시클로알킬), -S(O)(C1-8 할로알킬), -S(O)(아릴), -S(O)(헤테로아릴), -S(O)(헤테로시클릴), -S(O)2(C1-9 알킬), -S(O)2(C2-6 알케닐), -S(O)2(C2-6 알키닐), -S(O)2(C3-15 시클로알킬), -S(O)2(C1-8 할로알킬), -S(O)2(아릴), -S(O)2(헤테로아릴), -S(O)2(헤테로시클릴), -S(O)2NH(C1-9 알킬), 또는 -S(O)2N(C1-9 알킬)2이고;여기서 임의의 알킬, 시클로알킬, 아릴, 헤테로아릴, 또는 헤테로시클릴은 1개 이상의 할로, C1-9 알킬, C1-8 할로알킬, -OH, -NH2, -NH(C1-9 알킬), -NH(C3-15 시클로알킬), -NH(C1-8 할로알킬), -NH(아릴), -NH(헤테로아릴), -NH(헤테로시클릴), -N(C1-9 알킬)2, -N(C3-15 시클로알킬)2, -NHC(O)(C3-15 시클로알킬), -NHC(O)(C1-8 할로알킬), -NHC(O)(아릴), -NHC(O)(헤테로아릴), -NHC(O)(헤테로시클릴), -NHC(O)O(C1-9 알킬), -NHC(O)O(C2-6 알키닐), -NHC(O)O(C3-15 시클로알킬), -NHC(O)O(C1-8 할로알킬), -NHC(O)O(아릴), -NHC(O)O(헤테로아릴), -NHC(O)O(헤테로시클릴), -NHC(O)NH(C1-9 알킬), -S(O)(NH)(C1-9 알킬), S(O)2(C1-9 알킬), -S(O)2(C3-15 시클로알킬), -S(O)2(C1-8 할로알킬), -S(O)2(아릴), -S(O)2(헤테로아릴), -S(O)2(헤테로시클릴), -S(O)2NH(C1-9 알킬), -S(O)2N(C1-9 알킬)2, -O(C3-15 시클로알킬), -O(C1-8 할로알킬), -O(아릴), -O(헤테로아릴), -O(헤테로시클릴), 또는 -O(C1-9 알킬)로 임의로 치환되고;단 R1이 C3 알킬이고, R2가 F 및 히드록실로 치환된 C5 알킬이고, R3, R...