Substituted aryl acylthioureas and related compounds, inhibitors of viral replicationThe present invention provides some aryl thiourea derivatives and the pharmaceutically acceptable salts. These compositions have effective antiviral activity. The present invention especially provides the compounds that are effective and/or selective inhibitors of Hepatitis C virus replication. The present invention also provides the pharmaceutical composition combining the compound of the invention and at least one pharmaceutically acceptable excipient, the pharmaceutical composition with a whole set formula, the pharmaceutical composition included in the container and the instruction of using the composition for treating the viral infection. The invention also comprises a method for inhibiting the Hepatitis C virus replication by contacting the compound of the invention with the cell infected with Hepatitis C virus, and a method for treating or inhibiting the Hepatitis C virus replication by using the compound of the invention with a certain amount to the patient.Compound or pharmaceutically acceptable salt thereof, wherein said compound is1-(4-penta phenyl)-3-(1,2,3-thiadiazoles-4-carbonyl) thiocarbamide;1-(3-(4-phenyl-benzyloxy) phenyl)-3-(2-morpholinyl ethanoyl) thiocarbamide;1-(3-cyano group benzoyl)-3-(3-benzyloxy-phenyl) thiocarbamide;1-(1-methyl piperidine-3-carbonyl)-3-(4-pentyloxy phenyl) thiocarbamide;1-(1-methyl piperidine-3-carbonyl)-3-(4-penta phenyl) thiocarbamide;1-(4-(pentyloxy) phenyl)-3-(quinoxaline-7-carbonyl) thiocarbamide;1-(4-penta phenyl)-3-(quinoline-3-carbonyl) thiocarbamide;1-(4-(pentyloxy) phenyl)-3-(quinoxaline-7-carbonyl) thiocarbamide;1-(4-penta phenyl)-3-(quinoxaline-7-carbonyl) thiocarbamide;1-(2-methyl-5-(trifluoromethyl) oxazole-4-carbonyl)-3-(4-penta phenyl) thiocarbamide;1-(2-methyl-5-(trifluoromethyl) oxazole-4-carbonyl)-3-(4-(pentyloxy) phenyl) thiocarbamide;1-(4-penta phenyl)-3-(1,2,3-thiadiazoles-4-carbonyl) thiocarbamide;1-(4-pentyloxy phenyl)-3-(1,2,3-thiadiazoles-4-carbonyl) thiocarbamide;1-(3-fluoro-4-(pentyloxy) phenyl)-3-(h-imidazo [1,2-a] pyridine-6-carbonyl) thiocarbamide;1-(1-(2-amino-2-oxoethyl)-2-oxo-1,2-dihydropyridine-5-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(3-cyclopropyl-4-(pentyloxy) phenyl)-3-nicotinoyl thiocarbamide;1-(1-methyl-2-oxo-1,2-dihydropyridine-5-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(4-(hexyloxy) phenyl)-3-(1-methyl-2-oxo-1,2-dihydropyridine-5-carbonyl) thiocarbamide;2-oxo-2-(5-((3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thioureido) carbonyl) pyridine-2-base is amino) methyl acetate;2-(5-((3-(4-(oxygen base in heptan) phenyl) thioureido) carbonyl) pyridine-2-base is amino)-2-oxo methyl acetate;1-(4-pentyloxy-3-trifluoromethyl-phenyl)-3-(pyridine-3-carbonyl) thiocarbamide;1-(2-(2-amino-2-oxo kharophen) nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(5-methyl-4,5,6,7-tetrahydrofuran (thf) be [3,2-c] pyridine-2-carbonyl also)-3-(4-(pentyloxy) phenyl) thiocarbamide;1-(2-(1h-imidazoles-1-yl) ethanoyl)-3-(4-(pentyloxy) phenyl) thiocarbamide;1-(4-(pentyloxy) phenyl)-3-(3-(pyridin-3-yl) propionyl) thiocarbamide;1-(3-fluoro-4-(4-phenylpiperidine-1-yl) phenyl)-3-nicotinoyl thiocarbamide;1-(4-(cyclohexyl methoxyl group)-3-fluorophenyl)-3-nicotinoyl thiocarbamide;1-(4-(4-hexyl dicyclo [2.2.2] suffering-1-yl) phenyl)-3-nicotinoyl thiocarbamide;1-nicotinoyl-3-(4-((1s, 4r)-4-propyl group cyclohexyl) phenyl) thiocarbamide;1-(4-((1 s, 4r)-4-hexyl cyclohexyl) phenyl)-3-nicotinoyl thiocarbamide;1-(3-phenoxyphenyl)-3-(2-(tetramethyleneimine-1-yl) nicotinoyl) thiocarbamide;1-(3-(benzyloxy) phenyl)-3-(2-(tetramethyleneimine-1-yl) nicotinoyl) thiocarbamide;1-(6-(pentyloxy) pyridin-3-yl)-3-(2-(tetramethyleneimine-1-yl) nicotinoyl) thiocarbamide;1-(3-(2,3-dihydro-1h-indenes-2-base oxygen) phenyl)-3-(2-(tetramethyleneimine-1-yl) nicotinoyl) thiocarbamide;1-(2-(2-(dimethylamino) oxyethyl group) nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(5-methyl-isoxazole-3-carbonyl)-3-(6-(pentyloxy) pyridin-3-yl) thiocarbamide;1-(4-methyl isophthalic acid, 2,3-thiadiazoles-5-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(the 3-tertiary butyl-1-methyl isophthalic acid h-pyrazoles-5-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(2-methyl nicotinoyl)-3-(6-pentyloxy) pyridin-3-yl) thiocarbamide;1-(1,3-dimethyl-1h-pyrazoles-5-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(6-(pentyloxy) pyridin-3-yl)-3-(2-(pyridin-4-yl) thiazole-4-carbonyl) thiocarbamide;1-(6-(pentyloxy) pyridin-3-yl)-3-(2-phenyl-5-(trifluoromethyl) oxazole-4-carbonyl) thiocarbamide;1-(4-(pentyloxy)-3-(trifluoromethyl) phenyl)-3-(2-(pyridin-3-yl) thiazole-4-carbonyl) thiocarbamide;1-(2-methyl isophthalic acid, 8-naphthyridines-3-carbonyl)-3-(6-(pentyloxy) pyridin-3-yl) thiocarbamide;1-(2,7-dimethyl pyrazole [1,5-a] pyrimidine-6-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(2-methyl-5-(trifluoromethyl) oxazole-4-carbonyl)-3-(6-(pentyloxy) pyridin-3-yl) thiocarbamide;1-(4-methyl-2-phenyl-2h-1,2,3-triazole-5-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(5-methyl-isoxazole-4-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(5-methyl-isoxazole-3-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(6-(pentyloxy) pyridin-3-yl)-3-(1,2,3-thiadiazoles-4-carbonyl) thiocarbamide;1-(2-methyl h-imidazo [1,2-a] pyridine-3-carbonyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(isoxazole-5-carbonyl)-3-(6-(pentyloxy) pyridin-3-yl) thiocarbamide;1-(2-methyl nicotinoyl)-3-(4-(pentyloxy)-3-(trifluoromethyl) phenyl) thiocarbamide;1-(benzo [c] [1,2,5] oxadiazole-6-carbonyls)-3-(6-(pentyloxy) pyridin-3-yl) thiocarbamide;1-(4-(pentyloxy)-3-(trifluoromethyl) phenyl)-3-(2-(pyridin-4-yl) thiazole-4-carbonyl) thiocarbamide;1-(1,3-dimethyl-1h-thieno-[2,3-c] pyrazoles-5-carbonyl)-3-(6-(pentyloxy) pyridin...
치환된 아릴 아실티오우레아 및 관련 화합물； 바이러스복제 억제제본 발명은 하기 식 (I)의 화합물 및 그것의 약제학적으로 허용되는 염을 제공하는데, 식에서 변수 A1, A2, R1, R2, V, W, X, Y, 및 Z는 본원에서 규정된 것과 같다:  식 I 본원에서 설명되는 식 (I)의 특정 화합물은 강력한 항-바이러스 활성을 나타낸다. 본 발명은 특히 C형 간염 바이러스 복제의 강력한 및/또는 선택적인 억제제인 식 (I)의 화합물을 제공한다. 본 발명은 또한 하나 또는 둘 이상의 식 (I)의 화합물 또는 그러한 화합물의 염, 용매 화합물, 또는 아실화된 선구약물과, 하나 또는 둘 이상의 약제학적으로 허용되는 담체, 부형제, 또는 희석제를 함유하는 약제학적 조성물을 제공한다. 본 발명은 또한 특정 감염성 질병에 걸려있는 환자에게 질병 또는 질환의 신호 또는 증상을 감소시키기에 효과적인 양의 식 I의 화합물을 투여하는 것으로 이루어지는, 환자의 치료 방법을 포함한다. 그러한 감염성 질병으로는 바이러스 감염, 특히 HCV 감염이 있다. 본 발명은 특히 감염성 질병에 걸린 사람 환자를 치료하는 방법뿐 아니라, 가축과 애완용 동물을 포함하여, 감염성 질병에 걸린 기타 동물을 치료하는 방법도 포함한다. 치료 방법은 단일 활성제로서 식 (I)의 화합물을 투여하는 것 또는 식 (I)의 화합물을 하나 또는 둘 이상의 다른 치료제와 함께 투여하는 것을 포함한다.화합물이 다음의 것인 것을 특징으로 하는 화합물 또는 그것의 약제학적으로 허용되는 염: l-(4-펜틸페닐)-3-(l,2,3-티아디아졸-4-카르보닐)티오우레아; 1-(3-(4-페닐-벤질옥시)페닐)-3-(2-모르폴리노아세틸)티오우레아; l-(3-시아노벤조일)-3-(3-벤질옥시-페닐)티오우레아; l-(l-메틸피페리딘-3-카르보닐)-3-(4-펜틸옥시페닐)티오우레아; 1-(1-메틸피페리딘-3-카르보닐)-3-(4-펜틸페닐)티오우레아; l-(4-(펜틸옥시)페닐)-3-(퀴녹살린-7-카르보닐)티오우레아; l-(4-펜틸페닐)-3-(퀴놀린-3-카르보닐)티오우레아; l-(4-(펜틸옥시)페닐)-3-(퀴녹살린-7-카르보닐)티오우레아; l-(4-펜틸페닐)-3-(퀴녹살린-7-카르보닐)티오우레아; l-(2-메틸-5-(트리플루오로메틸)옥사졸-4-카르보닐)-3-(4-펜틸페닐)티오우레아; l-(2-메틸-5-(트리플루오로메틸)옥사졸-4-카르보닐)-3-(4-(펜틸옥시)페닐)티오우레아; l-(4-펜틸페닐)-3-(l,2,3-티아디아졸-4-카르보닐)티오우레아; l-(4-펜톡시페닐)-3-(l,2,3-티아디아졸-4-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(H-이미다조[l,2-a]피리딘-6-카르보닐)티오우레아; l-(l-(2-아미노-2-옥소에틸)-2-옥소-l,2-디히드로피리딘-5-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(3-시클로프로필-4-(펜틸옥시)페닐)-3-니코티노일티우오레아; l-(l-메틸-2-옥소-l,2-디히드로피리딘-5-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(4-(헥실옥시)페닐)-3-(l-메틸-2-옥소-l,2-디히드로피리딘-5-카르보닐)티오우레아; 메틸 2-옥소-2-(5-((3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레이도)카르보닐)피리딘-2-일아미노)아세테이트; 메틸 2-(5-((3-(4-(헵틸옥시)페닐)티오우레이도)카르보닐)피리딘-2-일아미노)-2-옥소아세테이트; l-(4-펜틸옥시-3-트리플루오로메틸-페닐)-3-(피리딘-3-카르보닐)티오우레아; l-(2-(2-아미노-2-옥소아세트아미도)니코티노일)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(5-메틸-4,5,6,7-테트라히드로퓨로[3,2-c]피리딘-2-카르보닐)-3-(4-(펜틸옥시)페닐)티오우레아; 1 -(2-(1H-이미다졸-1-일)아세틸)-3-(4-(펜틸옥시)페닐)티오우레아; l-(4-(펜틸옥시)페닐)-3-(3-(피리딘-3-일)프로파노일)티오우레아; l-(3-플루오로-4-(4-페닐피페리딘-l-일)페닐)-3-니코티노일티오우레아; l-(4-(시클로헥실메톡시)-3-플루오로페닐)-3-니코티노일티오우레아; l-(4-(4-헥실비시클로[2.2.2]옥탄-l-일)페닐)-3-니코티노일티오우레아; 1-니코티노일-3-(4-((1s,4r)-4-프로필시클로헥실)페닐)티오우레아; l-(4-((ls,4r)-4-헥실시클로헥실)페닐)-3-니코티노일티오우레아; l-(3-페녹시페닐)-3-(2-(피롤리딘-l-일)니코티노일)티오우레아; l-(3-(벤질옥시)페닐)-3-(2-(피롤리딘-1-일)니코티노일)티오우레아; l-(6-(펜틸옥시)피리딘-3-일)-3-(2-(피롤리딘-l-일)니코티노일)티오우레아; l-(3-(2,3-디히드로-lH-인덴-2-일옥시)페닐)-3-(2-(피롤리딘-l-일)니코니노일)티오우레아; l-(2-(2-(디메틸아미노)에톡시)니코티노일)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; 1-(5-메틸이소옥사졸-3-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; l-(4-메틸-l,2,3-티아디아졸-5-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; 1-(3-tert-부틸-1-메틸-lH-피라졸-5-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(2-메틸니코티노일)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; l-(l,3-디메틸-lH-피라졸-5-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(6-(펜틸옥시)피리딘-3-일)-3-(2-(피리딘-4-일)티아졸-4-카르보닐)티오우레아; l-(6-(펜틸옥시)피리딘-3-일)-3-(2-페닐-5-(트리플루오로메틸)옥사졸-4-카르보닐)티오우레아; l-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)-3-(2-(피리딘-3-일)티아졸-4-카르보닐)티오우레아; l-(2-메틸-l,8-나프티리딘-3-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; 1-(2,7-디메틸피라졸로[l,5-a]피리미딘-6-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(2-메틸-5-(트리플루오로메틸)옥사졸-4-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; l-(4-메틸-2-페닐-2H-l,2,3-트리아졸-5-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(5-메틸이소옥사졸-4-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(5-메틸이소옥사졸-3-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(6-(펜틸옥시)피리딘-3-일)-3-(l,2,3-티아디아졸-4-카르보닐)티오우레아; l-(2-메틸lH-이미다조[l,2-a]피리딘-3-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(이소옥사졸-5-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; 1-(2-메틸니코티노일)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(벤조[c][l,2,5]옥사디아졸-6-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; l-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)-3-(2-(피리딘-4-일)티아졸-4-카르보닐)티오우레아; l-(l,3-디메틸-lH-티에노[2,3-c]피라졸-5-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; 1-(2-메틸-l,8-나프티리딘-3-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(2-메틸-5-(트리플루오로메틸)옥사졸-4-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)-3-(l,2,3-티아디아졸-4-카르보닐)티오우레아; l-(이소옥사졸-5-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(벤조[c][l,2,5]옥사디아졸-6-카르보닐)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; 1-(3-플루오로-4-(펜틸옥시)페닐)-3-(4-메틸-1,2,3-티아디아졸-5-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(4-메틸-l,2,3-티아디아졸-5-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(2-(피리딘-3-일)티아졸-4-카르보닐)티오우레아; l-(2,7-디메틸피라졸로[1,5-a]피리미딘-6-카르보닐)-3-(3-플루오로-4-(펜틸옥시)페닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(4-메틸-2-페닐-2H-l,2,3-트리아졸-5-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(5-메틸이소옥사졸-4-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(5-메틸이소옥사졸-3-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(2-(피리딘-4-일)티아졸-4-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(2-페닐-5-(트리플루오로메틸)옥사졸-4-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(2-메틸-l,8-나프티리딘-3-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(2-메틸-5-(트리플루오로메틸)옥사졸-4-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(l,2,3-티아디아졸-4-카르보닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(이소옥사졸-5-카르보닐)티오우레아; 1-(벤조[c][1,2,5]옥사디아졸-6-카르보닐)-3-(3-플루오로-4-(펜틸옥시)페닐)티오우레아; l-(l,3-디메틸-lH-티에노[2,3-c]피라졸-5-카르보닐)-3-(3-플로우로-4-(펜틸옥시)페닐)티오우레아; 1 -(4-메틸-1,2,3-티아디아졸-5-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; 1-(1,3-디메틸-1H-피라졸-5-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; 1-(6-(펜틸옥시)피리딘-3-일)-3-(2-(피리딘-3-일)티아졸-4-카르보닐)티오우레아; 1-(2,7-디메틸피라졸로[1,5-a]피리미딘-6-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; 1-(4-메틸-2-페닐-2H-1,2,3-트리아졸-5-카르보닐)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; l-(3-(벤질옥시)페닐)-3-(2-(4-메틸피페라진-l-일)니코티노일)티오우레아; l-(2-(4-메틸피페라진-1-일)니코티노일)-3-(3-페녹시페닐)티오우레아; l-(2-(4-메틸피페라진-1-일)니코티노일)-3-(4-펜틸페닐)티오우레아; 1-(2-(4-메틸피페라진-1-일)니코티노일)-3-(4-(펜틸옥시)페닐)티오우레아; 1-(3-플루오로-4-(펜틸옥시)페닐)-3-(2-(4-메틸피페라진-1-일)니코티노일)티오우레아; 1-(2-(4-메틸피페라진-1-일)니코티노일)-3-(6-(펜틸옥시)피리딘-3-일)티오우레아; 1-(2-(4-메틸피페라진-1-일)니코티노일)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(3-메틸-4-(펜틸옥시)페닐)-3-(2-(4-메틸피페라진-l-일)니코티노일)티오우레아; l-(2-히드록시니코티노일)-3-(3-페녹시페닐)티오우레아; 1-(2-히드록시니코티노일)-3-(4-(펜틸옥시)페닐)티오우레아; 1-(2-히드록시니코티노일)-3-(4-펜틸페닐)티오우레아; l-(3-플루오로-4-(펜틸옥시)페닐)-3-(2-히드록시니코티노일)티오우레아; l-(2-히드록시니코티노일)-3-(4-(펜틸옥시)-3-(트리플루오로메틸)페닐)티오우레아; l-(2-히드록시니코티노일)-3-(4-(피페리딘-l-일)-3-(트리플루오로메틸)페닐)티오우레아; l-(4-(메틸(펜틸)아미노)-3-(트리플루오로메틸)페닐)-3-니코티...