Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides and use as renin inhibitors The invention relates to novel δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amides of formula (I)  or a pharmaceutically acceptable salt thereof. A compound of formula (I)  or a pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, independently of one another, are hydrogen; halogen; hydroxyl, C1-C7-alkanoyloxy, C1-C7-alkyl; or is C1-C7-alkyl that is substituted by: halogen, cyano, hydroxy, C1-C7-alkanoyl-oxy, C1-C7-alkoxy, C1-C7-alkoxy that is substituted by halogen or by hydroxyl, C2-C7-alkenyloxy, C3-C7-cycloalkoxy, C1-C7-alkylthio, S-oxidized C1-C7-alkylthio, amino, N-mono-C1-C7-alkylamino, N,N-di-C1-C7-alkyl-amino, N—C1-C7-alkanoyl-amino, N—C1-C7-alkanesulfonyl-amino, amino that is N,N-disubstituted by C2-C7-alkylene, by unsubstituted or N′-C1-C7-alkyl- or N′-C1-C7-alkanoyl-aza-C2-C7-alkylene, by oxa-C1-C7-alkylene, by thia-C1-C7-alkylene or by S-oxidized thia-C1-C7-alkylene, free or esterified or amidated carboxy, C3-C7-cycloalkyl, aryl, heteroaryl, hydrogenated heteroaryl or by oxo; or is C1-C7-alkoxy-C2-C7-alkenyl; or C1-C7-alkoxy; or is C1-C7-alkoxy that is substituted by: halogen, cyano, hydroxyl, C1-C7-alkanoyl-oxy, C1-C7-alkoxy, C1-C7-alkoxy that is substituted by halogen or by hydroxy, C2-C7-alkenyloxy, C3-C7-cycloalkoxy, C1-C7-alkylthio, S-oxidized C1-C7-alkylthio, amino, N-mono-C1-C7-alkylamino, N,N-di-C1-C7-alkyl-amino, N—C1-C7-alkanoyl-amino, N—C1-C7-alkanesulfonyl-amino, amino that is N,N-disubstituted by C2-C7-alkylene, by unsubstituted or N′-C1-C7-alkyl- or N′-C1-C7-alkanoyl-aza-C2-C7-alkylene, by oxa-C1-C7-alkylene, by thia-C1-C7-alkylene or by S-oxidized thia-C1-C7-alkylene, free or esterified or amidated carboxy, C3-C7-cycloalkyl, aryl, heteroaryl, or by hydrogenated heteroaryl; or is C2-C7-alkenyloxy; C1-C7-alkoxy-C2-C7-alkenyloxy; C3-C7-cycloalkoxy; C1-C7-alkanoyl; C3-C7-cycloalkyl; aryl; heteroaryl; or hydrogenated heteroaryl; or R3 together with R4 form C2-C7-alkylenedioxy or a fused-on benzo or cyclohexeno ring; X is methylene; hydroxymethylene; O; NH; S; SO; or SO2; R5 is C1-C7-alkyl; C2-C7-alkenyl; C3-C7-Cycloalkyl; C3-C7-cycloalkyl-C1-C7-alkyl; aryl-C1-C7alkyl; heteroaryl-C1-C7-alkyl; aryl or heteroaryl; R6 is amino; N-mono-C1-C7-amino; N,N-di-C1-C7-amino; N—C1-C7-alkanoyl-amino; N—C1-C7-alkanesulfonyl or represents a group of the formula —NR10COCHR11NR12R13, the latter may be present either in the (D)-, (L)- or racemic (D, L)-configuration, but preferably in the L-form; R7 is C1-C7-alkyl, C2-C7-alkenyl; C3-C7-cycloalkyl; C3-C7-cycloalkyl-C1-C7-alkyl; aryl-C1-C7-alkyl; heteroaryl-C1-C7-alkyl; aryl or heteroaryl; R8 is hydrogen; C1-C7-alkyl; or is C1-C7-alkyl that is substituted by: halogen, cyano, hydroxy, C1-C7-alkanoyl-oxy, C1-C7-alkoxy, C1-C7-alkoxy that is substituted by halogen or by hydroxyl, C2-C7-alkenyloxy, C3-C7-cycloalkoxy, C1-C7-alkylthio, S-oxidized C1-C7-alkylthio, amino, N-mono-C1-C7-alkylamino, N,N-di-C1-C7-alkyl-amino, N—C1-C7-alkanoyl-amino, N—C1-C7-alkanesulfonyl-amino, amino that is N,N-disubstituted by C2-C7-alkylene, by unsubstituted or N′-C1-C7-alkyl- or N′-C1-C7-alkanoyl-aza-C2-C7-alkylene, by oxa-C1-C7-alkylene, by thia-C1-C7-alkylene or by S-oxidized thia-C1-C7-alkylene, free or esterified or amidated carboxy, or is C1-C7-alkanoyl; C3-C7-cycloalkyl, aryl, heteroaryl, hydrogenated heteroaryl; C3-C7-cycloalkyl; aryl; heteroaryl or hydrogenated heteroaryl; R9 represents C1-C7-alkanoyl, C1-C7-alkanesulfonyl or a group of the formula —COCHR14NR11R12 which may be present either in the (DY, (L)- or racemic (D, L)-configuration, but preferably in the L-form; or a group of the formula —CH2O—COR15; R10 is hydrogen; C1-C7-alkyl; C3-C7-cycloalkyl; C3-C7-cycloalkyl-C1-C7-alkyl; aryl-C1-C7-alkyl; heteroaryl-C1-C7-alkyl; aryl or heteroaryl; R11 is hydrogen; C1-C7-alkyl; aryl-C1-C7-alkyl; heteroaryl-C1-C7-alkyl; aryl or heteroaryl; R12 and R13, independently of another, are hydrogen; C1-C7-alkyl; C1-C7-alkyl that is substituted by: halogen, C3-C7-cycloalkyl, aryl, heteroaryl, C1-C7-alkoxycarbonyl, C1-C7-alkylthio, by S-oxidized C1-C7-alkylthio, by aminocarbonyl, by N—C1-C7-alkanoyl-aminocarbonyl, by N—C1-C7-alkyl-aminocarbonyl; by N,N-di-C1-C7-alkyl-aminocarbonyl, or by aminocarbonyl that is disubstituted by C2-C7-alkylene; or are C3-C7-cycloalkyl; aryl or heteroaryl; R14 is hydrogen; C1-C7-alkyl; aryl-C1-C7-alkyl; heteroaryl-C1-C7-alkyl; aryl or heteroaryl; and R15 is C1-C7-alkyl, aryl-C1-C7-alkyl; heteroaryl-C1-C7-alkyl; aryl or heteroaryl. 
델타-아미노-감마-히드록시-오메가-아릴-알칸산 아미드 및레닌 억제제로서의 용도본 발명은 하기 화학식 I의 신규한 δ-아미노-γ-히드록시-ω-아릴-알칸산 아미드 또는 그의 제약상 허용가능한 염에 관한 것이다. <화학식 I> 하기 화학식 I의 화합물 또는 그의 제약상 허용가능한 염. <화학식 I>  식 중, R1, R2, R3, R4는 서로 독립적으로 수소, 할로겐, 히드록실, C1-C7-알카노일옥시, C1-C7-알킬, 또는 할로겐, 시아노, 히드록시, C1-C7-알카노일옥시, C1-C7-알콕시, (할로겐 또는 히드록실로) 치환된 C1-C7-알콕시, C2-C7-알케닐옥시, C3-C7-시클로알콕시, C1-C7-알킬티오, S-산화된 C1-C7-알킬티오, 아미노, N-모노-C1-C7-알킬아미노, N,N-디-C1-C7-알킬-아미노, N-C1-C7-알카노일-아미노, N-C1-C7-알칸술포닐-아미노, 또는 (C2-C7-알킬렌, 비치환된- 또는 N'-C1-C7-알킬- 또는 N'-C1-C7-알카노일-아자-C2-C7-알킬렌, 옥사-C1-C7-알킬렌, 티아-C1-C7-알킬렌 또는 S-산화된 티아-C1-C7-알킬렌, 유리 또는 에스테르화 또는 아미드화 카르복시, C3-C7-시클로알킬, 아릴, 헤테로아릴, 수소화 헤테로아릴 또는 옥소로) N,N-이치환된 아미노로 치환된 C1-C7-알킬, 또는 C1-C7-알콕시-C2-C7-알케닐, 또는 C1-C7-알콕시, 또는 할로겐, 시아노, 히드록실, C1-C7-알카노일옥시, C1-C7-알콕시, (할로겐 또는 히드록시로) 치환된 C1-C7-알콕시, C2-C7-알케닐옥시, C3-C7-시클로알콕시, C1-C7-알킬티오, S-산화된 C1-C7-알킬티오, 아미노, N-모노-C1-C7-알킬아미노, N,N-디-C1-C7-알킬-아미노, N-C1-C7-알카노일-아미노, N-C1-C7-알칸술포닐-아미노, 또는 (C2-C7-알킬렌, 비치환된- 또는 N'-C1-C7-알킬- 또는 N'-C1-C7-알카노일-아자-C2-C7-알킬렌, 옥사-C1-C7-알킬렌, 티아-C1-C7-알킬렌 또는 S-산화된 티아-C1-C7-알킬렌, 유리 또는 에스테르화 또는 아미드화 카르복시, C3-C7-시클로알킬, 아릴, 헤테로아릴 또는 수소화 헤테로아릴로) N,N-이치환된 아미노로 치환된 C1-C7-알콕시, 또는 C2-C7-알케닐옥시, C1-C7-알콕시-C2-C7-알케닐옥시, C3-C7-시클로알콕시, C1-C7-알카노일, C3-C7-시클로알킬, 아릴, 헤테로아릴, 또는 수소화 헤테로아릴이거나; 또는 R3및 R4는 함께 C2-C7-알킬렌디옥시 또는 융합된-벤조 또는 시클로헥세노 고리를 형성하고; X는 메틸렌, 히드록시메틸렌, O, NH, S, SO, 또는 SO2이고; R5는 C1-C7-알킬, C2-C7-알케닐, C3-C7-시클로알킬, C3-C7-시클로알킬-C1-C7-알킬, 아릴-C1-C7-알킬, 헤테로아릴-C1-C7-알킬, 아릴 또는 헤테로아릴이고; R6은 아미노, N-모노-C1-C7-아미노, N,N-디-C1-C7-아미노, N-C1-C7-알카노일-아미노, N-C1-C7-알칸술포닐이거나, 또는 화학식 -NR10COCHR11NR12R13의 기 (이는 (D)-, (L)- 또는 라세미 (D,L)-배열로 존재할 수 있지만, L-형태가 바람직함)를 나타내고; R7은 C1-C7-알킬, C2-C7-알케닐, C3-C7-시클로알킬, C3-C7-시클로알킬-C1-C7-알킬, 아릴-C1-C7-알킬, 헤테로아릴-C1-C7-알킬, 아릴 또는 헤테로아릴이고; R8은 수소, C1-C7-알킬, 또는 할로겐, 시아노, 히드록시, C1-C7-알카노일옥시, C1-C7-알콕시, (할로겐 또는 히드록실로) 치환된 C1-C7-알콕시, C2-C7-알케닐옥시, C3-C7-시클로알콕시, C1-C7-알킬티오, S-산화된 C1-C7-알킬티오, 아미노, N-모노-C1-C7-알킬아미노, N,N-디-C1-C7-알킬-아미노, N-C1-C7-알카노일-아미노, N-C1-C7-알칸술포닐-아미노, 또는 (C2-C7-알킬렌, 비치환된- 또는 N'-C1-C7-알킬- 또는 N'-C1-C7-알카노일-아자-C2-C7-알킬렌, 옥사-C1-C7-알킬렌, 티아-C1-C7-알킬렌 또는 S-산화된 티아-C1-C7-알킬렌, 유리 또는 에스테르화 또는 아미드화 카르복시로) N,N-이치환된 아미노로 치환된 C1-C7-알킬, 또는 C1-C7-알카노일, C3-C7-시클로알킬, 아릴, 헤테로아릴, 수소화 헤테로아릴, C3-C7-시클로알킬, 아릴, 헤테로아릴 또는 수소화 헤테로아릴이고; R9는 C1-C7-알카노일, C1-C7-알칸술포닐, 화학식 -COCHR14NR11R12의 기 (이는 (D)-, (L)- 또는 라세미 (D,L)-배열로 존재할 수 있지만, L-형태가 바람직함), 또는 화학식 -CH2O-COR15의 기를 나타내고; R10은 수소, C1-C7-알킬, C3-C7-시클로알킬, C3-C7-시클로알킬-C1-C7-알킬, 아릴-C1-C7-알킬, 헤테로아릴-C1-C7-알킬, 아릴 또는 헤테로아릴이고; R11은 수소, C1-C7-알킬, 아릴-C1-C7-알킬, 헤테로아릴-C1-C7-알킬, 아릴 또는 헤테로아릴이고; R12 및 R13은 서로 독립적으로 수소, C1-C7-알킬, 또는 할로겐, C3-C7-시클로알킬, 아릴, 헤테로아릴, C1-C7-알콕시카르보닐, C1-C7-알킬티오, S-산화된 C1-C7-알킬티오, 아미노카르보닐, N-C1-C7-알카노일-아미노카르보닐, N-C1-C7-알킬-아미노카르보닐, N,N-디-C1-C7-알킬-아미노카르보닐, 또는 (C2-C7-알킬렌으로) 이치환된 아미노카르보닐로 치환된 C1-C7-알킬, 또는 C3-C7-시클로알킬, 아릴 또는 헤테로아릴이고; R14는 수소, C1-C7-알킬, 아릴-C1-C7-알킬, 헤테로아릴-C1-C7-알킬, 아릴 또는 헤테로아릴이며; R15는 C1-C7-알킬, 아릴-C1-C7-알킬, 헤테로아릴-C1-C7-알킬, 아릴 또는 헤테로아릴이다.