FUSED PYRAZOLE AS p38 MAP KINASE INHIBITORSFused pyrazoles effective as p38 MAP kinase inhibitors, methods of making the compounds, and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.A compound selected from the group consisting of: l-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidin-4-yl- amino] -2-methyl-propan-2-ol; [3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidin-4-yl]-(2- methoxy-ethyl)-amine; 3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-4-(2-methyl-propane-2-sulfonylmethyl)- lH-pyrazolo[3,4-d]pyrimidine; l-[3-Cyclohexyl-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidin-4-ylamino]- propan-2-ol;3-Cyclopentyl-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[4,3-b]pyridine; 3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-4- (propane- 2- sulfonylmethyl)- IH- pyrazolo[3,4-d]pyrimidine;5-{2-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidin-4-yl- amino] -ethyl }-2,4-dimethyl-2,4-dihydro-[ 1,2,4] triazol-3-one;2-[6-(2,4-Difluoro-phenoxy)-3-isobutyl-lH-pyrazolo[3,4-d]pyrimidin-4-ylamino]- propane-l,3-diol; [3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-b]pyridin-4-yl]-[2-(2- methyl-imidazol- l-yl)-ethyl] -amine; 6-(2,4-Difluoro-phenoxy)-3-(tetrahydro-pyran-4-yl)-lH-pyrazolo[3,4-d]pyrimidine;3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-4-ethanesulfonylmethyl-lH-pyrazolo[3,4- d]pyrimidine; 3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-b]pyridine-5-carb- aldehyde; [3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-b]pyridin-5-yl]- methanol; 4-{2-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidin-4-yl- amino] -ethyl }-2-methyl-2,4-dihydro-[ 1,2,4] triazol-3-one; 6-(2,4-Difluoro-phenoxy)-3-isopropyl-lH-pyrazolo[3,4-d]pyrimidine; [6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-yl]-(3-methanesulfonyl-propyl)-amine; [6-(2,4-Difluoro-phenoxy)-3-(2,4-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-yl]-(3-methanesulfonyl-propyl)-amine; l-{[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-b]pyridin-5-yl- methyl] -amino }-propan-2-ol;3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-5-methoxy-lH-pyrazolo[3,4-b]pyridine; 3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-b]pyridin-5-ol; [6-(2,4-Difluoro-phenoxy)-3-(2,4-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-yl]-(l-methanesulfonyl-piperidin-4-yl)-amine; [6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-yl]-(l-methanesulfonyl-piperidin-4-yl)-amine;3-[2-Chloro-5-(tetrahydro-pyran-2-yloxy)-phenyl]-6-(2,4-difluoro-phenoxy)-lH- pyrazolo[3,4-d]pyrimidine;N-{2-[6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-ylamino] -ethyl }-methanesulfonamide; N-{2-[6-(2,4-Difluoro-phenoxy)-3-(2,4-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-ylamino] -ethyl }-methanesulfonamide; 4-Chloro-3-[6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidin-3-yl]-phenylamine; 2-[6-(2,4-Difluoro-phenoxy)-3-(2,4-difluoro-phenyl)-lH-pyrazolo[3,4-b]pyridin-4-yl- amino] -propane- 1,3-diol; 2-[6-(2,4-Difluoro-phenoxy)-3-(2,4-difluoro-phenyl)-lH-pyrazolo[4,3-c]pyridin-4-yl- amino] -propane- 1,3-diol; [6-(2,4-Difluoro-phenoxy)-3-(2,4-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-yl]- dimethyl- amine; l-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenylamino)-lH-pyrazolo[3,4-b]pyrazin-5-yl- amino] -propan-2-ol;3-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-b]pyridin-5-yloxy]- propane- 1,2-diol;3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-5-(tetrahydro-pyran-4-yloxy)-lH- pyrazolo [ 3,4-b] pyridine; 3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-5-(2-methoxy-ethoxy)-lH-pyrazolo[3,4- bjpyridine; 3-(2-Chloro-phenyl)-N*6*-(2,4-difluoro-phenyl)-N*5*-(2-methanesulfonyl-ethyl)-lH- pyrazolo[3,4-b]pyrazine-5,6-diamine; l-[6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-yl- amino] -2-methyl-propan-2-ol; l-{2-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidin-4-yl- amino] -ethyl }-3-methyl-urea; l-{2-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidin-4-yl- amino] -ethyl }-3-methylamino-sulfonamide; 2-[6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[3,4-b]pyridin-4-yl- amino] -propane- 1,3-diol; 3-Cyclohexyl-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidine;3-[2-Chloro-5-(tetrahydro-pyran-2-yloxy)-phenyl]-6-(2,4-difluoro-phenoxy)-lH- pyrazolo [ 3,4-b] pyridine;4-Chloro-3-[6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-b]pyridin-3-yl] -phenol; 3-[6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[4,3-c]pyridin-4-yl- oxy] -propane- 1,2-diol;3-{4-Chloro-3-[6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-b]pyridin-3-yl]-phenoxy}- propane- 1,2-diol; l-[6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[3,4-b]pyridin-4-yl- amino] -2-methyl-propan-2-ol; l-[6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[4,3-c]pyridin-4-yl- amino] -2-methyl-propan-2-ol;3-Cyclopentyl-6-(2,4-difluoro-phenoxy)-lH-pyrazolo[3,4-d]pyrimidine; l-[6-(2,4-Difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-lH-pyrazolo[3,4-d]pyrimidin-4-yl- amino] -propan-2-ol; l-[6-(2,4-Difluoro-phenoxy)-3-(2,...
ｐ38 ＭＡＰ 키나아제 저해제로서의 융합형 피라졸 p38 MAP 키나아제 저해제로서 효과적인 융합형 피라졸, 이 화합물의 제조 방법, 및 이 화합물을 p38 MAP 키나아제 매개 질환의 치료에 사용하는 방법이 개시되어 있다.  하기로 이루어지는 군에서 선택되는 화합물: 1-[3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-2-메틸-프로판-2-올; [3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-4-일]-(2-메톡시-에틸)-아민; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-4-(2-메틸-프로판-2-설포닐메틸)-1H-피라졸로[3,4-d]피리미딘; 1-[3-사이클로헥실-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-4-일아미노]-프로판-2-올; 3-사이클로펜틸-6-(2,4-디플루오로-페녹시)-1H-피라졸로[4,3-b]피리딘; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-4-(프로판-2-설포닐메틸)-1H-피라졸로-[3,4-d]피리미딘; 5-{2-[3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-에틸}-2,4-디메틸-2,4-디하이드로-[1,2,4]트리아졸-3-온; 2-[6-(2,4-디플루오로-페녹시)-3-이소부틸-1H-피라졸로[3,4-d]피리미딘-4-일아미노]-프로판-1,3-디올; [3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-4-일]-[2-(2-메틸-이미다졸-1-일)-에틸]-아민; 6-(2,4-디플루오로-페녹시)-3-(테트라하이드로-피란-4-일)-1H-피라졸로[3,4-d]피리미딘; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-4-에탄설포닐메틸-1H-피라졸로[3,4-d]-피리미딘; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-카르브알데하이드; [3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-일]-메탄올; 4-{2-[3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-에틸}-2-메틸-2,4-디하이드로-[1,2,4]트리아졸-3-온; 6-(2,4-디플루오로-페녹시)-3-이소프로필-1H-피라졸로[3,4-d]피리미딘; [6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일]-(3-메탄설포닐-프로필)-아민; [6-(2,4-디플루오로-페녹시)-3-(2,4-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일]-(3-메탄설포닐-프로필)-아민; 1-{[3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-일-메틸]-아미노}-프로판-2-올; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-5-메톡시-1H-피라졸로[3,4-b]피리딘; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-올; [6-(2,4-디플루오로-페녹시)-3-(2,4-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일]-(1-메탄설포닐-피페리딘-4-일)-아민; [6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일]-(1-메탄설포닐-피페리딘-4-일)-아민; 3-[2-클로로-5-(테트라하이드로-피란-2-일옥시)-페닐]-6-(2,4-디플루오로-페녹시)-1H-피라졸로-[3,4-d]피리미딘; N-{2-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일아미노]-에틸}-메탄설폰아미드; N-{2-[6-(2,4-디플루오로-페녹시)-3-(2,4-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일아미노]-에틸}-메탄설폰아미드; 4-클로로-3-[6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-3-일]-페닐아민; 2-[6-(2,4-디플루오로-페녹시)-3-(2,4-디플루오로-페닐)-1H-피라졸로[3,4-b]피리딘-4-일-아미노]-프로판-1,3-디올; 2-[6-(2,4-디플루오로-페녹시)-3-(2,4-디플루오로-페닐)-1H-피라졸로[4,3-c]피리딘-4-일-아미노]-프로판-1,3-디올; [6-(2,4-디플루오로-페녹시)-3-(2,4-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일]-디메틸-아민; 1-[3-(2-클로로페닐)-6-(2,4-디플루오로-페닐아미노)-1H-피라졸로[3,4-b]피라진-5-일-아미노]-프로판-2-올; 3-[3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-일옥시]-프로판-1,2-디올; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-5-(테트라하이드로-피란-4-일옥시)-1H-피라졸로-[3,4-b]피리딘; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-5-(2-메톡시-에톡시)-1H-피라졸로[3,4-b]-피리딘; 3-(2-클로로페닐)-N*6*-(2,4-디플루오로-페닐)-N*5*-(2-메탄설포닐-에틸)-1H-피라졸로[3,4-b]피라진-5,6-디아민; 1-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-2-메틸-프로판-2-올; 1-{2-[3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-에틸}-3-메틸-우레아; 1-{2-[3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-에틸}-3-메틸아미노-설폰아미드; 2-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-b]피리딘-4-일-아미노]-프로판-1,3-디올; 3-사이클로헥실-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘; 3-[2-클로로-5-(테트라하이드로-피란-2-일옥시)-페닐]-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘; 4-클로로-3-[6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-3-일]-페놀; 3-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[4,3-c]피리딘-4-일-oxy]-프로판-1,2-디올; 3-{4-클로로-3-[6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-3-일]-페녹시}-프로판-1,2-디올; 1-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-b]피리딘-4-일-아미노]-2-메틸-프로판-2-올; 1-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[4,3-c]피리딘-4-일-아미노]-2-메틸-프로판-2-올; 3-사이클로펜틸-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘; 1-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-프로판-2-올; 1-[6-(2,4-디플루오로-페녹시)-3-(2,4-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-프로판-2-온; 2-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[4,3-c]피리딘-4-일-아미노]-프로판-1,3-디올; [3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-일]-(4-메틸-피페라진-1-일)-메타논; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-카르복실산 (2-하이드록시-프로필)-아미드; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-카르복실산 (2-디메틸아미노-에틸)-아미드; 1-[3-[2-클로로-5-(2-하이드록시-에톡시)-페닐]-6-;(2,4-디플루오로-페녹시)-1H-피라졸로-[3,4-d]피리미딘-4-일아미노]-프로판-2-올 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-카르복실산 (2,3-디하이드록시-프로필)-아미드; 1-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일-아미노]-프로판-2-온; 3-[2-클로로-5-(4H-[1,2,4]트리아졸-3-일메틸)-페닐]-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘; 2-{4-클로로-3-[6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-3-일]-페닐}-아세트아미드; 3-tert-부틸-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘; 6-(2,4-디플루오로-페녹시)-3-(2,2-디메틸-프로필)-1H-피라졸로[3,4-d]피리미딘; [6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일]-[2-(1,1-디옥소-1람다*6*-이소티아졸리딘-2-일)-에틸]-아민; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-4-(모르폴린-4-설포닐메틸)-1H-피라졸로[3,4-d]피리미딘; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-일아민; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-카르복실산 메틸 에스테르; 3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-카르복실산; 3-{5-클로로-4-[6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-3-일]-피리딘-2-일옥시}-프로판-1,2-디올; 3-{5-클로로-4-[6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-3-일]-피리딘-2-일아미노}-프로판-1,2-디올; 1-[3-(3,5-디클로로-피리딘-4-일)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-4-일아미노]-2-메틸-프로판-2-올; N-[3-(2-클로로페닐)-6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-b]피리딘-5-일]-아세트아미드; 3-{2-[6-(2,4-디플루오로-페녹시)-3-(2,5-디플루오로-페닐)-1H-피라졸로[3,4-d]피리미딘-4-일아미노]-에틸}-1,5,5-트리메틸-이미다졸리딘-2,4-디온; 1-{5-클로로-4-[6-(2,4-디플루오로-페녹시)-1H-피라졸로[3,4-d]피리미딘-3-일]-...