COMPOUNDS FOR TREATING HUNTINGTON'S DISEASEThe present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.A compound comprising a compound of formula (i),or a form thereof, wherein:w1、w2、w3、w4、w5and w6independently is c-ra、c-rbor the number of n is greater than the number of n,wherein when w1、w5and w6when one, two or three of them are n, w2、w3and w4is c-raor c-rband is andwherein when w2、w3and w4when one, two or three of them are n, w1、w5and w6is c-raor c-rb；r1is c1-8alkyl, c1-8alkylamino radical, (c)1-8alkyl radical)2-amino, c1-8alkoxy-c1-8alkyl-alkyl, (c)1-8alkoxy-c1-8alkyl radical)2-amino, (c)1-8alkoxy-c1-8alkyl) (c1-8alkyl) amino, amino-c1-8alkyl radical, c1-8alkyl-amino-c1-8alkyl, (c)1-8alkyl radical)2-amino-c1-8alkyl radical, c1-8alkoxy-c1-8alkyl-amino-c1-8alkyl, (c)1-8alkoxy-c1-8alkyl radical)2-amino-c1-8alkyl, (c)1-8alkoxy-c1-8alkyl) (c1-8alkyl) amino-c1-8alkyl, amino-c1-8alkyl-amino, (amino-c)1-8alkyl radical)2-amino, (amino-c)1-8alkyl) (c1-8alkyl) amino, c1-8alkyl-amino-c1-8alkyl-amino, (c)1-8alkyl-amino-c1-8alkyl radical)2-amino, (c)1-8alkyl-amino-c1-8alkyl) (c1-8alkyl) amino, (c)1-8alkyl radical)2-amino-c1-8alkyl-amino, [ (c)1-8alkyl radical)2-amino-c1-8alkyl radical](c1-8alkyl) amino, amino-c1-8alkoxy radical, c1-8alkyl-amino-c1-8alkoxy group, (c)1-8alkyl radical)2-amino-c1-8alkoxy radical, c1-8alkoxy-c1-8alkyl-amino-c1-8alkoxy radical, c1-8alkoxy-c1-8alkyl-amino-c1-8alkoxy group, (c)1-8alkoxy-c1-8alkyl) (c1-8alkyl) amino-c1-8alkoxy, amino-c2-8alkenyl radical, c1-8alkyl-amino-c2-8alkenyl, (c)1-8alkyl radical)2-amino-c2-8alkenyl, amino-c2-8alkynyl, c1-8alkyl-amino-c2-8alkynyl, (c)1-8alkyl radical)2-amino-c2-8alkynyl, halogen-c1-8alkyl-amino, (halogen-c)1-8alkyl radical)2-amino, (halogen-c1-8alkyl) (c1-8alkyl) amino, hydroxy-c1-8alkyl, hydroxy-c1-8alkoxy-c1-8alkyl, hydroxy-c1-8alkyl-amino, (hydroxy-c)1-8alkyl radical)2-amino, (hydroxy-c)1-8alkyl) (c1-8alkyl) amino, hydroxy-c1-8alkyl-amino-c1-8alkyl, (hydroxy-c)1-8alkyl radical)2-amino-c1-8alkyl, (hydroxy-c)1-8alkyl) (c1-8alkyl) amino-c1-8alkyl, hydroxy-c1-8alkyl-amino-c1-8alkoxy group, (hydroxy-c)1-8alkyl radical)2-amino-c1-8alkoxy group, (hydroxy-c)1-8alkyl) (c1-8alkyl) amino-c1-8alkoxy, hydroxy-c1-8alkyl-amino-c1-8alkyl-amino, (hydroxy-c)1-8alkyl-amino-c1-8alkyl radical)2-amino, (hydroxy-c)1-8alkyl radical)2-amino-c1-8alkyl-amino, (hydroxy)-c1-8alkyl-amino-c1-8alkyl) (c1-8alkyl) amino, (hydroxy-c)1-8alkyl) (c1-8alkyl) amino-c1-8alkyl-amino, [ (hydroxy-c)1-8alkyl radical)2-amino-c1-8alkyl radical](c1-8alkyl) amino, [ (hydroxy-c)1-8alkyl) (c1-8alkyl) amino-c1-8alkyl radical](c1-8alkyl) amino, c3-14cycloalkyl, aryl-c1-8alkyl-amino, (aryl-c)1-8alkyl radical)2-amino, (aryl-c)1-8alkyl) (c1-8alkyl) amino, aryl-c1-8alkyl-amino-c1-8alkyl, (aryl-c)1-8alkyl radical)2-amino-c1-8alkyl, (aryl-c)1-8alkyl) (c1-8alkyl) amino-c1-8alkyl, heterocyclyl-c1-8alkyl, heterocyclyl-c1-8alkoxy, heterocyclyl-amino, (heterocyclyl) (c)1-8alkyl) amino, heterocyclyl-amino-c1-8alkyl, heterocyclyl-c1-8alkyl-alkyl, (heterocyclyl-c)1-8alkyl radical)2-amino, (heterocyclyl-c)1-8alkyl) (c1-8alkyl) amino, heterocyclyl-c1-8alkyl-amino-c1-8alkyl, (heterocyclyl-c1-8alkyl radical)2-amino-c1-8alkyl, (heterocyclyl-c1-8alkyl) (c1-8alkyl) amino-c1-8alkyl, heterocyclyl-oxy, heterocyclyl-carbonyl-oxy, heteroaryl-c1-8alkyl, heteroaryl-c1-8alkoxy, heteroaryl-amino, heteroaryl-c1-8alkyl-amino, (heteroaryl-c)1-8alkyl radical)2-amino, (heteroaryl-c)1-8alkyl) (c1-8alkyl) amino, heteroaryl-c1-8alkyl-amino-c1-8alkyl, (heteroaryl-c)1-8alkyl radical)2-amino-c1-8alkyl, or (heteroaryl-c)1-8alkyl) (c1-8alkyl) amino-c1-8an alkyl group, a carboxyl group,wherein c is3-14each example of cycloalkyl, aryl, heterocyclyl and heteroaryloptionally substituted by one, two or three r3is substituted by a substituent and is optionally substituted by one additional r4a substituent is substituted, orwherein, optionally, c3-14each instance of cycloalkyl, aryl, heterocyclyl, and heteroaryl is optionally substituted with one, two, three, or four r3substituent group substitution;r2is aryl, heteroaryl-amino, (heteroaryl) (c)1-8alkyl) amino or (heterocyclyl) (c)1-8alkyl) amino group(s),wherein each instance of aryl and heteroaryl is optionally substituted with one, two or three r6is substituted by a substituent and is optionally substituted by one additional r7substituent group substitution;in each instance, raindependently selected from hydrogen or c1-8an alkyl group;in each instance, rbindependently selected from hydrogen or halogen;in each instance, r3independently selected from cyano, halogen, hydroxy, c1-8alkyl, halogen-c1-8alkyl radical, c1-8alkyl-c1-8carbonyl group, c1-8alkoxy, halogen-c1-8alkoxy radical, c1-8alkoxy-c1-8alkyl radical, c1-8alkoxy-carbonyl, amino, c1-8alkyl-amino, (c)1-8alkyl radical)2-amino, amino-c1-8alkyl radical, c1-8alkyl-amino-c1-8alkyl, (c)1-8alkyl radical)2-amino-c1-8alkyl, amino-c1-8alkyl-amino, c1-8alkyl-amino-c1-8alkyl-amino, (c)1-8alkyl-amino-c1-8alkyl radical)2-amino, (c)1-8alkyl radical)2-amino-c1-8alkyl-amino, [ (c)1-8alkyl radical)2-amino-c1-8alkyl radical]2-amino, (c)1-8alkyl-amino-c1-8alkyl...
헌팅턴병 치료 화합물본 발명은 헌팅턴병을 치료 또는 개선하기 위해 화합물, 형태 및 약제학적 조성물 및 이러한 화합물, 형태 또는 조성물을 사용하는 방법에 관한 것이다. [화학식 I][이미지] 특히, 본 발명은 화학식 I의 치환된 이환식 헤테로아릴 화합물, 이의 형태 및 약제학적 조성물, 및 헌팅턴병을 치료 또는 개선하기 위해 상기 화합물, 형태 또는 이의 조성물을 사용하는 방법에 관한 것이다.하기 화학식 I의 화합물 또는 이의 형태를 포함하는 화합물로서,[화학식 I][이미지]여기서:W1, W2, W3, W4, W5 및 W6은 독립적으로 C-Ra, C-Rb 또는 N이고,여기서, W1, W5 및 W6 중 1, 2 또는 3개가 N인 경우, W2, W3 및W4는 C-Ra 또는 C-Rb이고,여기서, W2, W3 및 W4 중 1, 2 또는 3개가 N인 경우, W1, W5 및 W6은 C-Ra 또는 C-Rb이고;R1은 C1-8알킬, 아미노, C1-8알킬-아미노, (C1-8알킬)2-아미노, C1-8알콕시-C1-8알킬-아미노, (C1-8알콕시-C1-8알킬)2-아미노, (C1-8알콕시-C1-8알킬)(C1-8알킬)아미노, 아미노-C1-8알킬, C1-8알킬-아미노-C1-8알킬, (C1-8알킬)2-아미노-C1-8알킬, C1-8알콕시-C1-8알킬-아미노-C1-8알킬, (C1-8알콕시-C1-8알킬)2-아미노-C1-8알킬, (C1-8알콕시-C1-8알킬)(C1-8알킬)아미노-C1-8알킬, 아미노-C1-8알킬-아미노, (아미노-C1-8알킬)2-아미노, (아미노-C1-8알킬)(C1-8알킬)아미노 , C1-8알킬-아미노-C1-8알킬-아미노, (C1-8알킬-아미노-C1-8알킬)2-아미노, (C1-8알킬-아미노-C1-8알킬)(C1-8알킬)아미노, (C1-8알킬)2-아미노-C1-8알킬-아미노, [(C1-8알킬)2-아미노-C1-8알킬](C1-8알킬)아미노, 아미노-C1-8알콕시, C1-8알킬-아미노-C1-8알콕시, (C1-8알킬)2-아미노-C1-8알콕시, C1-8알콕시-C1-8알킬-아미노-C1-8알콕시, C1-8알콕시-C1-8알킬-아미노-C1-8알콕시, (C1-8알콕시-C1-8알킬)(C1-8알킬)아미노-C1-8알콕시, 아미노-C2-8알케닐, C1-8알킬-아미노-C2-8알케닐, (C1-8알킬)2-아미노-C2-8알케닐, 아미노-C2-8알키닐, C1-8알킬-아미노-C2-8알키닐, (C1-8알킬)2-아미노-C2-8알키닐, 할로-C1-8알킬-아미노, (할로-C1-8알킬)2-아미노, (할로-C1-8알킬)(C1-8알킬)아미노, 하이드록시-C1-8알킬, 하이드록시-C1-8알콕시-C1-8알킬, 하이드록시-C1-8알킬-아미노, (하이드록시-C1-8알킬)2-아미노, (하이드록시-C1-8알킬)(C1-8알킬)아미노, 하이드록시-C1-8알킬-아미노-C1-8알킬, (하이드록시-C1-8알킬)2-아미노-C1-8알킬, (하이드록시-C1-8알킬)(C1-8알킬)아미노-C1-8알킬, 하이드록시-C1-8알킬-아미노-C1-8알콕시, (하이드록시-C1-8알킬)2-아미노-C1-8알콕시, (하이드록시-C1-8알킬)(C1-8알킬)아미노-C1-8알콕시, 하이드록시-C1-8알킬-아미노-C1-8알킬-아미노, (하이드록시-C1-8알킬-아미노-C1-8알킬)2-아미노, (하이드록시-C1-8알킬)2-아미노-C1-8알킬-아미노, (하이드록시-C1-8알킬-아미노-C1-8알킬)(C1-8알킬)아미노, (하이드록시-C1-8알킬)(C1-8알킬)아미노-C1-8알킬-아미노, [(하이드록시-C1-8알킬)2-아미노-C1-8알킬](C1-8알킬)아미노, [(하이드록시-C1-8알킬)(C1-8알킬)아미노-C1-8알킬](C1-8알킬)아미노, C3-14사이클로알킬, 아릴, 아릴-C1-8알킬-아미노, (아릴-C1-8알킬)2-아미노, (아릴-C1-8알킬)(C1-8알킬)아미노, 아릴-C1-8알킬-아미노-C1-8알킬, (아릴-C1-8알킬)2-아미노-C1-8알킬, (아릴-C1-8알킬)(C1-8알킬)아미노-C1-8알킬, 헤테로사이클릴, 헤테로사이클릴-C1-8알킬, 헤테로사이클릴-C1-8알콕시, 헤테로사이클릴-아미노, (헤테로사이클릴)(C1-8알킬)아미노, 헤테로사이클릴-아미노-C1-8알킬, 헤테로사이클릴-C1-8알킬-아미노, (헤테로사이클릴-C1-8알킬)2-아미노, (헤테로사이클릴-C1-8알킬)(C1-8알킬)아미노, 헤테로사이클릴-C1-8알킬-아미노-C1-8알킬, (헤테로사이클릴-C1-8알킬)2-아미노-C1-8알킬, (헤테로사이클릴-C1-8알킬)(C1-8알킬)아미노-C1-8알킬, 헤테로사이클릴-옥시, 헤테로사이클릴-카르보닐, 헤테로사이클릴-카르보닐-옥시, 헤테로아릴, 헤테로아릴-C1-8알킬, 헤테로아릴-C1-8알콕시, 헤테로아릴-아미노, 헤테로아릴-C1-8알킬-아미노, (헤테로아릴-C1-8알킬)2-아미노, (헤테로아릴-C1-8알킬)(C1-8알킬)아미노, 헤테로아릴-C1-8알킬-아미노-C1-8알킬, (헤테로아릴-C1-8알킬)2-아미노-C1-8알킬 또는 (헤테로아릴-C1-8알킬)(C1-8알킬)아미노-C1-8알킬이고,여기서, C3-14사이클로알킬, 아릴, 헤테로사이클릴 및 헤테로아릴의 각 경우는 1, 2 또는 3개의 R3 치환기로 선택적으로 치환되고, 선택적으로 1개의 추가 R4 치환기로 치환되거나, 또는대안적으로, C3-14사이클로알킬, 아릴, 헤테로사이클릴 및 헤테로아릴의 각 경우는 1, 2, 3 또는 4개의 R3 치환기로 선택적으로 치환되고;R2는 아릴, 헤테로아릴, 헤테로아릴-아미노, (헤테로아릴)(C1-8알킬)아미노 또는 (헤테로사이클릴)(C1-8알킬)아미노이고,여기서, 아릴 및 헤테로아릴의 각 경우는 1, 2 또는 3개의 R6 치환기로 선택적으로 치환되고, 선택적으로 1개의 추가 R7 치환기로 치환되고;Ra는 각 경우에 수소, 또는 C1-8알킬로부터 독립적으로 선택되고;Rb는 각 경우에 수소, 또는 할로겐으로부터 독립적으로 선택되고;R3은 각 경우에 시아노, 할로겐, 하이드록시, C1-8알킬, 할로-C1-8알킬, C1-8알킬-카르보닐, C1-8알콕시, 할로-C1-8알콕시, C1-8알콕시-C1-8알킬, C1-8알콕시-카르보닐, 아미노, C1-8알킬-아미노, (C1-8알킬)2-아미노, 아미노-C1-8알킬, C1-8알킬-아미노-C1-8알킬, (C1-8알킬)2-아미노-C1-8알킬, 아미노-C1-8알킬-아미노, C1-8알킬-아미노-C1-8알킬-아미노, (C1-8알킬-아미노-C1-8알킬)2-아미노, (C1-8알킬)2-아미노-C1-8알킬-아미노, [(C1-8알킬)2-아미노-C1-8알킬]2-아미노, (C1-8알킬-아미노-C1-8알킬)(C1-8알킬)아미노, [(C1-8알킬)2-아미노-C1-8알킬](C1-8알킬)아미노, C1-8알콕시-C1-8알킬-아미노, (C1-8알콕시-C1-8알킬)2-아미노, (C1-8알콕시-C1-8알킬)(C1-8알킬)아미노, C1-8알킬-카르보닐-아미노, C1-8알콕시-카르보닐-아미노, 하이드록시-C1-8알킬, 하이드록시-C1-8알콕시-C1-8알킬, 하이드록시-C1-8알킬-아미노, (하이드록시-C1-8알킬)2-아미노 또는 (하이드록시-C1-8알킬)(C1-8알킬)아미노로부터 독립적으로 선택되고,R4는 C3-14사이클로알킬, C3-14사이클로알킬-C1-8알킬, C3-14사이클로알킬-아미노, 아릴-C1-8알킬, 아릴-C1-8알콕시-카르보닐, 아릴-술포닐옥시-C1-8알킬, 헤테로사이클릴, 헤테로사이클릴-C1-8알킬, 헤테로아릴 또는 헤테로아릴-C1-8알킬이고; 여기서, C3-14사이클로알킬, 아릴, 헤테로사이클릴 및 헤테로아릴의 각 경우는 1, 2 또는 3개의 R5 치환기로 선택적으로 치환되고;R5는 각 경우에 할로겐, 하이드록시, 시아노, 니트로, C1-8알킬, 할로-C1-8알킬, C1-8알콕시, 할로-C1-8알콕시, 하이드록시-C1-8알킬, 아미노, C1-8알킬-아미노, (C1-8알킬)2-아미노, (C1-8알킬)2-아미노-C1-8알킬, C1-8알킬-티오 또는 헤테로아릴-C1-8알킬로부터 독립적으로 선택되고;R6은 각 경우에 할로겐, 하이드록시, 시아노, 니트로, C1-8알킬, C2-8알케닐, 시아노-C1-8알킬, 할로-C1-8알킬, 하이드록시-C1-8알킬, C1-8알콕시, 할로-C1-8알콕시, (C1-8알킬)2-아미노-C1-8알콕시, C1-8알콕시-C1-8알킬, C1-8알콕시-C1-8알콕시, 아미노, C1-8알킬-아미노, (C1-8알킬)2-아미노, C1-8알콕시-C1-8알킬-아미노, (C1-8알콕시-C1-8알킬, C1-8알킬)아미노 또는 C1-8알킬-티오로부터 독립적으로 선택되고; 및,R7은 C3-14사이클로알킬, C3-14사이클로알킬-옥시, 아릴, 헤테로사이클릴, 헤테로아릴 또는 헤테로아릴-C1-8알콕시이고;여기서 화합물의 형태는 이의 전구약물, 염, 수화물, 용매화물, 클라트레이트, 동위이성질체, 라세미체, 거울상이성질체, 부분입체이성질체, 입체이성질체, 다형체 및 호변이성질체 형태로 구성된 군으로부터 선택되는, 화합물.