Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapyThe present invention relates toaminotetralineand aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetralineand ami- noindane derivatives, and the use of such aminotetralineand aminoindane derivatives for therapeutic purposes. The aminotetraline and aminoindane derivatives are GlyT1 inhibitors.The compound of formula (i), or its salt physiologically toleratedwhereina is 5 or 6 rings；r1for hydrogen, c1-c6alkyl, c3-c12cycloalkyl-c1-c4alkyl, halo c1-c6alkyl, three-(c1-c4alkyl)-monosilane base-c1-c4alkyl, hydroxyl-c1-c4alkyl, c1-c6alkoxy-c1-c4alkyl, amino-c1-c4alkyl, c1-c6alkyl amino- c1-c4alkyl, two-c1-c6alkyl amino-c1-c4alkyl, c1-c6alkyl-carbonyl-amino-c1-c4alkyl, c1-c6alkoxy carbonyl amino-c1-c4alkyl, c1-c6alkyl amino-carbonyl-amino-c1-c4alkyl, two-c1-c6alkyl amino-carbonyl-amino-c1-c4alkane base, c1-c6alkyl sulfonyl-amino-c1-c4alkyl, (optionally substituted c6-c12aryl-c1-c6alkyl) amino-c1-c4alkyl, optionally substituted c6-c12aryl-c1-c4alkyl, optionally substituted m3-m12heterocyclic radical-c1-c4alkyl, c3-c12cycloalkyl, c1-c6 alkyl-carbonyl, c1-c6alkoxy carbonyl, halo c1-c6alkoxy carbonyl, c6-c12aryloxycarbonyl, amino carbonyl, c1-c6alkyl amino carbonyl, (halo c1-c4alkyl) amino carbonyl, c6-c12aromatic yl aminocarbonyl, c2-c6thiazolinyl, c2-c6alkynyl, optionally substituted c6-c12aryl, hydroxyl, c1-c6alkoxyl, halo c1-c6alkoxyl, c1-c6hydroxy alkoxy base, c1-c6alkoxy-c1-c4alkane epoxide, amino-c1-c4alkoxyl, c1-c6alkyl amino-c1-c4alkoxyl, two-c1-c6alkyl amino-c1-c4alkoxyl, c1- c6alkyl-carbonyl-amino-c1-c4alkoxyl, c6-c12aryl-amino-carbonyl-c1-c4alkoxyl, c1-c6alkoxycarbonyl amino-c1- c4alkoxyl, c6-c12aryl-c1-c4alkoxyl, c1-c6alkyl sulfonyl-amino-c1-c4alkoxyl, (halo c1-c6-alkyl) sulfuryl amino-c1-c4alkoxyl, c6-c12arlysulfonylamino-c1-c4alkoxyl, (c6-c12aryl-c1-c6alkyl) sulphur acyl amino-c1-c4alkoxyl, m3-m12heterocyclyl sulfonyl amino-c1-c4alkoxyl, m3-m12heterocyclic radical-c1-c4alkoxyl, c6-c12aryloxy group, m3-m12heterocyclic radical epoxide, c1-c6alkyl sulfenyl, halo c1-c6alkyl sulfenyl, c1-c6alkyl amino, (halo c1-c6alkyl) amino, two-c1-c6alkyl amino, two-(halo c1-c6alkyl) amino, c1-c6alkyl-carbonyl-amino, (halo c1-c6alkyl) carbonylamino, c6-c12aryl-amino-carbonyl, c1-c6alkyl sulfonyl-amino, (halo c1-c6alkyl) sulfonyl amino, c6-c12arlysulfonylamino or optionally substituted m3-m12heterocyclic radical；w is-nr7-or key；a1for optionally substituted c1-c4alkylidene or key；q is-s (o)2-or-c (o)-；y is-nr8-or key；n1 is 0,1,2 or 3,n2 is 0,1,2 or 3,x1for > n-or > ch-；r6for hydrogen, halogen, c1-c4alkyl, halo c1-c4alkyl ,-cn, hydroxyl, c1-c6alkoxyl or halo c1-c6alkoxyl, or two group r6carbonyl is formed together with its carbon atom connected；r2for hydrogen, halogen, c1-c6alkyl, halo c1-c4alkyl ,-cn, c2-c6thiazolinyl, c2-c6alkynyl, optionally substituted c6-c12 aryl, hydroxyl, c1-c6alkoxyl, halo c1-c6alkoxyl, c1-c6alkoxy carbonyl, c2-c6alkenyloxy group, c6-c12aryl-c1- c4alkoxyl, c1-c6alkyl-carbonyl epoxide, c1-c6alkyl sulfenyl, c1-c6alkyl sulphinyl, c1-c6alkyl sulphonyl, amino sulfonyl, amino, c1-c6alkyl amino, c2-c6alkenyl amino, nitro or optionally substituted m3-m12heterocyclic radical, or two groups r2annular atoms together with its a being bonded forms 5 or 6 rings；m is 0 or 1；r3for hydrogen, halogen, c1-c6alkyl or c1-c6alkoxyl, or two group r3formed together with its carbon atom connected carbonyl；y1for key or optionally substituted c1-c4alkylidene；r4afor hydrogen, c1-c6alkyl, c3-c12cycloalkyl-c1-c4alkyl, halo c1-c4alkyl, hydroxyl-c1-c4alkyl, c1-c6alkane epoxide-c1-c4alkyl, amino-c1-c4alkyl ,-ch2cn、c6-c12aryl-c1-c4alkyl, optionally substituted c3-c12cycloalkanes base ,-cho, c1-c4alkyl-carbonyl, (halo c1-c4alkyl) carbonyl, c6-c12aryl carbonyl, c1-c4alkoxy carbonyl, c6-c12virtue epoxide carbonyl, c1-c6alkyl amino-carbonyl, c2-c6thiazolinyl ,-c (=nh) nh2、-c(=nh)nhcn、c1-c6alkyl sulphonyl, c6- c12aryl sulfonyl, amino ,-no or optionally substituted m3-m12heterocyclic radical；orr4afor with y1in the optionally substituted c of carbon atom bonding1-c4alkylidene；r4bfor hydrogen, c1-c6alkyl, halo c1-c4alkyl, hydroxyl-c1-c4alkyl, c1-c6alkoxy-c1-c4alkyl, amino-c1- c4alkyl ,-ch2cn、-cho、c1-c4alkyl-carbonyl, (halo c1-c4alkyl) carbonyl, c6-c12aryl carbonyl, c1-c4alkoxyl carbonyl base, c6-c12aryloxycarbonyl, c1-c6alkyl amino-carbonyl, c2-c6thiazolinyl ,-c (=nh) nh2、-c(=nh)nhcn、c1-c6alkyl sulfonyl, c6-c12aryl sulfonyl, amino ,-no or m3-m12heterocyclic radical；orr4a、r4bit is optionally substituted c together2-c6alkylidene, wherein c2-c6one-ch of alkylidene2-can be by oxygen atom or-nr10substitute；x2for-o-,-nr11a-、-s-、>cr12ar12bor key；x3for-o-,-nr11b-、-s-、>cr13ar13bor key；r5for optionally substituted c6-c12aryl, optionally substituted c3-c12cycloalkyl or optionally substituted m3-m12heterocyclic radical；r7for hydrogen or c1-c6alkyl；r8for hydrogen, c1-c6alkyl, c3-c12cycloalkyl, amino-c1-c6alkyl, optionally substituted c6-c12aryl-c1-c4alkyl or m3-m12heterocyclic radical；orr8、r1it is c together1-c4alkylidene；r10for hydrogen or c1-c6alkyl；r11afor hydrogen or c1-c6alkyl；r11bfor hydrogen or c1-c6alkyl；r12afor hydrogen, optionally substituted c1-c6alkyl, c1-c6alkyl amino-c1-c4alkyl, two-c1-c6alkyl amino-c1-c4alkane base, m3-m12heterocyclic radical-c1-c6alkyl, optionally substituted c6-c12aryl or hydroxyl；r12bfor hydrogen or c1-c6a...
아미노테트랄린 및 아미노인단 유도체, 이들을 포함하는 약제학적 조성물, 및 치료에서 이들의 용도본 발명은 화학식 I의 아미노테트랄린 및 아미노인단 유도체 또는 생리학적으로 허용되는 이의 염에 관한 것이다. 화학식 I 본 발명은 이러한 아미노테트랄린 및 아미노인단 유도체를 포함하는 약제학적 조성물, 및 이러한 아미노테트랄린 및 아미노인단 유도체의 치료학적 목적을 위한 용도에 관한 것이다. 아미노테트랄린 및 아미노인단 유도체는 GlyT1 억제제이다.화학식 I의 화합물 또는 생리학적으로 허용되는 이의 염.화학식 I[이미지]상기 화학식 I에서, A는 5- 또는 6-원 환이고; R1은 수소, C1-C6-알킬, C3-C12-사이클로알킬-C1-C4-알킬, 할로겐화된 C1-C6-알킬, 트리-(C1-C4-알킬)-실릴-C1-C4-알킬, 하이드록시-C1-C4-알킬, C1-C6-알콕시-C1-C4-알킬, 아미노-C1-C4-알킬, C1-C6-알킬아미노-C1-C4-알킬, 디-C1-C6-알킬아미노-C1-C4-알킬, C1-C6-알킬카보닐아미노-C1-C4-알킬, C1-C6-알킬옥시카보닐아미노-C1-C4-알킬, C1-C6-알킬아미노카보닐아미노-C1-C4-알킬, 디-C1-C6-알킬아미노카보닐아미노-C1-C4-알킬, C1-C6-알킬설포닐아미노-C1-C4-알킬, (임의로 치환된 C6-C12-아릴-C1-C6-알킬)아미노-C1-C4-알킬, 임의로 치환된 C6-C12-아릴-C1-C4-알킬, 임의로 치환된 M3-M12-헤테로사이클릴-C1-C4-알킬, C3-C12-사이클로알킬, C1-C6-알킬카보닐, C1-C6-알콕시카보닐, 할로겐화된 C1-C6-알콕시카보닐, C6-C12-아릴옥시카보닐, 아미노카보닐, C1-C6-알킬아미노카보닐, (할로겐화된 C1-C4-알킬)아미노카보닐, C6-C12-아릴아미노카보닐, C2-C6-알케닐, C2-C6-알키닐, 임의로 치환된 C6-C12-아릴, 하이드록시, C1-C6-알콕시, 할로겐화된 C1-C6-알콕시, C1-C6-하이드록시알콕시, C1-C6-알콕시-C1-C4-알콕시, 아미노-C1-C4-알콕시, C1-C6-알킬아미노-C1-C4-알콕시, 디-C1-C6-알킬아미노-C1-C4-알콕시, C1-C6-알킬카보닐아미노-C1-C4-알콕시, C6-C12-아릴카보닐아미노-C1-C4-알콕시, C1-C6-알콕시카보닐아미노-C1-C4-알콕시, C6-C12-아릴-C1-C4-알콕시, C1-C6-알킬설포닐아미노-C1-C4-알콕시, (할로겐화된 C1-C6-알킬)설포닐아미노-C1-C4-알콕시, C6-C12-아릴설포닐아미노-C1-C4-알콕시, (C6-C12-아릴-C1-C6-알킬)설포닐아미노-C1-C4-알콕시, M3-M12-헤테로사이클릴설포닐아미노-C1-C4-알콕시, M3-M12-헤테로사이클릴-C1-C4-알콕시, C6-C12-아릴옥시, M3-M12-헤테로사이클릴옥시, C1-C6-알킬티오, 할로겐화된 C1-C6-알킬티오, C1-C6-알킬아미노, (할로겐화된 C1-C6-알킬)아미노, 디-C1-C6-알킬아미노, 디-(할로겐화된 C1-C6-알킬)아미노, C1-C6-알킬카보닐아미노, (할로겐화된 C1-C6-알킬)카보닐아미노, C6-C12-아릴카보닐아미노, C1-C6-알킬설포닐아미노, (할로겐화된 C1-C6-알킬)설포닐아미노, C6-C12-아릴설포닐아미노 또는 임의로 치환된 M3-M12-헤테로사이클릴이고; W는 -NR7- 또는 결합이고;A1은 임의로 치환된 C1-C4-알킬렌 또는 결합이고;Q는 -S(O)2- 또는 -C(O)-이고;Y는 -NR8- 또는 결합이고;n1은 0, 1, 2, 또는 3이고;n2는 0, 1, 2, 또는 3이고;X1은 >N- 또는 >CH-이고;R6은 수소, 할로겐, C1-C4-알킬, 할로겐화된 C1-C4-알킬, -CN, 하이드록시, C1-C6-알콕시 또는 할로겐화된 C1-C6-알콕시이거나, 2개의 라디칼 R6은, 이들이 부착된 탄소 원자와 함께, 카보닐 그룹을 형성하고; R2는 수소, 할로겐, C1-C6-알킬, 할로겐화된 C1-C4-알킬, -CN, C2-C6-알케닐, C2-C6-알키닐, 임의로 치환된 C6-C12-아릴, 하이드록시, C1-C6-알콕시, 할로겐화된 C1-C6-알콕시, C1-C6-알콕시카보닐, C2-C6-알케닐옥시, C6-C12-아릴-C1-C4-알콕시, C1-C6-알킬카보닐옥시, C1-C6-알킬티오, C1-C6-알킬설피닐, C1-C6-알킬설포닐, 아미노설포닐, 아미노, C1-C6-알킬아미노, C2-C6-알케닐아미노, 니트로 또는 임의로 치환된 M3-M12-헤테로사이클릴이거나, 2개의 라디칼 R2는, 이들이 결합된 A의 환 원자와 함께, 5- 또는 6-원 환을 형성하고;m은 0 또는 1이고;R3은 수소, 할로겐, C1-C6-알킬 또는 C1-C6-알콕시이거나, 2개의 라디칼 R3은, 이들이 부착된 탄소 원자와 함께, 카보닐 그룹을 형성하고;Y1은 결합 또는 임의로 치환된 C1-C4-알킬렌이고;R4a는 수소, C1-C6-알킬, C3-C12-사이클로알킬-C1-C4-알킬, 할로겐화된 C1-C4-알킬, 하이드록시-C1-C4-알킬, C1-C6-알콕시-C1-C4-알킬, 아미노-C1-C4-알킬, -CH2CN, C6-C12-아릴-C1-C4-알킬, 임의로 치환된 C3-C12-사이클로알킬, -CHO, C1-C4-알킬카보닐, (할로겐화된 C1-C4-알킬)카보닐, C6-C12-아릴카보닐, C1-C4-알콕시카보닐, C6-C12-아릴옥시카보닐, C1-C6-알킬아미노카보닐, C2-C6-알케닐, -C(=NH)NH2, -C(=NH)NHCN, C1-C6-알킬설포닐, C6-C12-아릴설포닐, 아미노, -NO 또는 임의로 치환된 M3-M12-헤테로사이클릴이거나;R4a는 Y1에서 탄소 원자에 결합된 임의로 치환된 C1-C4-알킬렌이고;R4b는 수소, C1-C6-알킬, 할로겐화된 C1-C4-알킬, 하이드록시-C1-C4-알킬, C1-C6-알콕시-C1-C4-알킬, 아미노-C1-C4-알킬, -CH2CN, -CHO, C1-C4-알킬카보닐, (할로겐화된 C1-C4-알킬)카보닐, C6-C12-아릴카보닐, C1-C4-알콕시카보닐, C6-C12-아릴옥시카보닐, C1-C6-알킬아미노카보닐, C2-C6-알케닐, -C(=NH)NH2, -C(=NH)NHCN, C1-C6-알킬설포닐, C6-C12-아릴설포닐, 아미노, -NO 또는 M3-M12-헤테로사이클릴이거나; R4a, R4b는 함께 임의로 치환된 C2-C6-알킬렌이고, 여기서, C2-C6-알킬렌의 하나의 -CH2-는 산소 원자 또는 -NR10으로 대체될 수 있고;X2는 -O-, -NR11a-, -S-, >CR12aR12b 또는 결합이고;X3은 -O-, -NR11b-, -S-, >CR13aR13b 또는 결합이고;R5는 임의로 치환된 C6-C12-아릴, 임의로 치환된 C3-C12-사이클로알킬 또는 임의로 치환된 M3-M12-헤테로사이클릴이고; R7은 수소 또는 C1-C6-알킬이고;R8은 수소, C1-C6-알킬, C3-C12-사이클로알킬, 아미노-C1-C6-알킬, 임의로 치환된 C6-C12-아릴-C1-C4-알킬 또는 M3-M12-헤테로사이클릴이거나;R8, R1은 함께 C1-C4-알킬렌이고;R10은 수소 또는 C1-C6-알킬이고;R11a는 수소 또는 C1-C6-알킬이고;R11b는 수소 또는 C1-C6-알킬이고;R12a는 수소, 임의로 치환된 C1-C6-알킬, C1-C6-알킬아미노-C1-C4-알킬, 디-C1-C6-알킬아미노-C1-C4-알킬, M3-M12-헤테로사이클릴-C1-C6-알킬, 임의로 치환된 C6-C12-아릴 또는 하이드록시이고;R12b는 수소 또는 C1-C6-알킬이거나, R12a, R12b는, 이들이 부착된 탄소 원자와 함께, 카보닐을 형성하거나, 임의로 치환된 C2-C4-알킬렌이고, 여기서, C2-C4-알킬렌의 하나의 -CH2-는 산소 원자 또는 -NR14-로 대체될 수 있고; R13a는 수소, 임의로 치환된 C1-C6-알킬, C1-C6-알킬아미노-C1-C4-알킬, 디-C1-C6-알킬아미노-C1-C4-알킬, M3-M12-헤테로사이클릴-C1-C6-알킬, 임의로 치환된 C6-C12-아릴 또는 하이드록시이고;R13b는 수소 또는 C1-C6-알킬이거나, R13a, R13b는, 이들이 부착된 탄소 원자와 함께, 카보닐을 형성하거나, 임의로 치환된 C1-C4-알킬렌이고, 여기서, C1-C4-알킬렌의 하나의 -CH2-는 산소 원자 또는 -NR15-로 대체될 수 있고; R14는 수소 또는 C1-C6-알킬이고; R15는 수소 또는 C1-C6-알킬이다.