Polypeptide marker for the diagnosis and evaluation of vascular diseasesThe invention relates to a method for the diagnosis of vascular diseases (VE). In said method, the presence or absence of at least one polypeptide marker in a sample is determined, said polypeptide marker being selected from markers 1 - 526, which are characterised by values for the molecular masses and the migration time (CE-time).One kind the diagnosis angiosis (VD) method, it comprises the step that whether has at least a polypeptide marker in the working sample, wherein said polypeptide marker is selected from mark 1～526, it is characterized in that having following molecular mass and transit time: No.QualityThe CE time No.QualityThe CE time No.QualityThe CE time No.QualityThe CE time No.QualityThe CE time 1 1166.61 23.88 51 11058.18 21.88 101 3984.81 21.29 151 2082.01 33.67 201 1013.41 25.33 2 2431.50 24.10 52 1352.61 29.86 102 4830.78 26.61 152 1768.90 20.77 202 1016.49 25.88 3 1922.93 31.99 53 2802.85 36.35 103 3031.39 35.93 153 3442.09 33.32 203 1493.74 22.06 4 2509.16 25.76 54 4890.88 26.46 104 3788.76 25.21 154 876.42 35.07 204 2104.04 32.97 5 3194.22 30.34 55 5212.06 26.98 105 2567.2 34.76 155 2352.14 26.74 205 3718.81 32.39 6 1705.90 40.47 56 945.45 25.80 106 1447.8 19.49 156 937.50 34.12 206 4251.98 28.66 7 1962.95 31.77 57 1065.55 25.50 107 2241.51 24.11 157 1445.72 28.36 207 4538.67 26.20 8 3822.12 24.72 58 1137.58 26.41 108 2461.11 30.84 158 1893.10 28.85 208 206793 20.68 9 2212.32 24.94 59 1542.77 23.91 109 1965.96 23.62 159 2839.43 24.14 209 2292.11 27.26 10 3015.78 35.86 60 1693.83 23.47 110 2189.08 27.17 160 1600.76 29.61 210 3702.39 32.39 11 1784.95 20.94 61 3361.42 24.26 111 1127.58 20.82 161 1565.75 26.35 211 965.46 27.84 12 1902.92 31.87 62 3617.74 26.97 112 1400.71 20.35 162 1527.76 29.47 212 2186.07 25.89 13 2329.15 27.17 63 3737.69 37.15 113 1512.75 39.51 163 1812.90 39.98 213 2564.29 35.08 14 2154.05 21.78 64 980.54 22.44 114 1860.53 34.24 164 3137.52 30.29 214 2841.13 24.50 15 2166.03 27.89 65 1221.63 26.82 115 1442.69 27.72 165 1364.67 28.65 215 9666.78 20.85 16 2258.27 21.99 66 2952.27 25.14 116 2590.78 27.96 166 2298.07 33.82 216 1099.53 28.33 17 2573.84 20.49 67 3696.88 26.94 117 1556.72 27.90 167 3017.74 49.66 217 2471.25 34.69 18 1270.75 37.92 68 5574.45 23.24 118 2309.15 21.95 168 1235.61 26.67 218 3734.85 32.41 19 1611.84 40.12 69 1182.59 28.34 119 2389.33 22.34 169 1741.61 30.21 219 3927.86 33.50 20 1791.87 41.04 70 1963.96 31.76 120 1478.68 39.28 170 1818.90 30.93 220 3166.32 22.10 21 2030.00 25.23 71 882.54 23.81 121 1795.90 24.66 171 1892.95 22.22 221 2339.08 33.95 22 1290.40 30.87 72 4002.72 20.69 122 2211.03 35.06 172 3280.69 22.69 222 2563.76 22.05 23 1441.74 39.13 73 4059.96 20.44 123 1223.63 19.52 173 2658.34 19.50 223 3219.35 35.00 24 2924.25 24.05 74 1186.59 22.31 124 1829.04 21.22 174 1407.71 27.46 224 3359.66 31.84 25 816.41 21.10 75 1825.87 31.80 125 1878.66 30.19 175 1622.79 26.82 225 4097.98 24.59 26 963.52 21.71 76 3401.66 23.42 126 2009.96 32.27 176 1664.78 29.64 226 4654.14 25.81 27 1503.74 29.63 77 1496.75 30.36 127 2110.00 24.10 177 1321.65 28.39 227 1584.77 29.72 28 2849.59 23.02 78 1832.92 31.91 128 1552.79 29.75 178 1350.68 27.13 228 2148.10 25.54 29 3133.20 31.20 79 2281.35 36.34 129 1577.75 40.03 179 1549.76 39.52 229 2639.45 21.33 30 1283.62 27.30 80 2344.34 33.66 130 1936.94 34.71 180 2233.10 22.47 230 3013.27 22.27 31 1495.75 23.31 81 3944.82 24.59 131 2368.13 26.75 181 2679.27 23.48 231 3205.39 19.71 32 1513.70 29.29 82 3002.23 23.80 132 3633.05 33.25 182 1835.79 20.02 232 3831.86 28.39 33 1612.83 23.36 83 3416.77 36.76 133 1510.72 28.30 183 3421.66 25.96 233 1050.52 27.03 34 2313.19 33.80 84 3501.86 31.79 134 1668.87 40.49 184 1708.85 30.44 234 2157.06 22.19 35 2436.23 22.87 85 6783.03 26.61 135 2227.05 33.43 185 1993.96 32.16 235 2407.16 27.65 36 2557.42 28.22 86 14111.27 21.97 136 1495.75 39.41 186 2695.31 23.46 236 2837.93 23.99 37 2626.85 28.00 87 2616.02 28.35 137 1631.77 45.38 187 1204.65 21.93 237 3058.02 30.20 38 2933.46 27.68 88 2810.45 36.73 138 3158.60 29.62 188 1467.86 24.38 238 1658.67 21.53 39 2994.09 29.50 89 2940.95 29.07 139 1522.78 22.76 189 1767.07 24.10 239 3311.32 24.46 40 4101.34 28.51 90 2946.45 34.96 140 1727.87 39.61 190 8176.30 19.57 240 3556.63 23.64 41 935.49 23.69 91 1494.72 30.40 141 1883.94 40.14 191 1143.56 36.97 241 1085.50 21.70 42 1521.75 30.42 92 1080.53 27.86 142 1460.71 19.83 192 1834.90 31.05 242 1199.63 21.91 43 1669.79 21.48 93 2349.14 27.36 143 1805.88 29.92 193 2025.95 32.21 243 1247.58 22.00 44 2758.37 28.94 94 3303.00 23.07 144 1898.93 40.30 194 3489.70 31.45 244 1608.76 22.36 45 3546.94 26.22 95 4081.56 24.51 145 2237.06 27.12 195 1268.62 27.29 245 2501.20 34.30 46 3609.63 20.22 96 4670.27 25.84 146 3178.33 30.26 196 1659.82 29.35 246 3021.52 23.52 47 3697.49 23.71 97 4671.99 23.33 147 1844.56 34.28 197 2405.59 22.16 247 4153.75 33.41 48 4278.73 23.34 98 8933.94 22.57 148 1378.57 37.16 198 2483.21 27.54 248 5000.17 24.43 49 4421.04 20.73 99 1523.90 29.72 149 1764.86 29.88 199 2599.21 28.20 249 8917.48 22.53 50 4805.67 26.49 100 3956.82 25.20 150 1791.88 30.77 200 4170.01 33.51 250 1750.86 23.80 No.QualityThe CE time No.QualityThe CE time No.QualityThe CE time No.QualityThe CE time 251 2235.13 34.10 301 1649.79 19.59 351 2073.17 27.43 401 1749.88 30.54 252 2644.25 21.13 302 4025.68 20.73 352 7958.65 34.32 402 1956.97 21.44 ...
혈관성 질환의 진단 및 평가를 위한 폴리펩티드 마커샘플 내에서 하나 이상의 폴리펩티드의 존재 또는 부재를 결정하는 단계를 포함하고, 상기 폴리펩티드 마커는 분자 질량 및 이동 시간 (CE 시간)에 대한 값에 의해 특징지어지는 마커 1번 내지 526번에서 선택되는 것인, 혈관성 질환(VD)을 진단하는 방법이 제공된다. 샘플 내에서 하나 이상의 폴리펩티드 마커의 존부를 결정하는 단계를 포함하고, 상기 폴리펩티드 마커는 하기 분자 질량 및 이동시간에 의해 특징지어지는 마커 1번 내지 526번에서 선택되는 것인 혈관성 질환(VD)을 진단하는 방법: [이미지] [이미지][이미지] 