Use of sulfonamide derivatives in the treatment of disordersof the metabolism and the nervous systemThe present invention relates generally to novel therapeutic compounds and AXOR 109 agonists, and processes for the manufacture and use  of the same.Pharmaceutical composition, it comprises and is selected from following compound or its salt or solvate:1) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-{[3-fluoro-4-(methoxyl group) phenyl] sulfonyl } piperazine;2) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-{[4-(1,3-oxazole-5-yl) phenyl] sulfonyl } piperazine;3) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-{[4-methyl-2-(methoxyl group) phenyl] sulfonyl } piperazine;4) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl } piperazine;5) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-[(2-chloro-6-aminomethyl phenyl) sulfonyl] piperazine;6) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-{[4-(methoxyl group) phenyl] sulfonyl } piperazine;7) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-{[3-fluoro-4-(methoxyl group) phenyl] sulfonyl } six hydrogen-1h-1, the 4-diaza 8) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-(2,3-dihydro-1,4-benzo dioxine-6-base sulfonyl) six hydrogen-1h-1, the 4-diaza 9) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl } six hydrogen-1h-1,4-diaza 10) n-methyl-n-[2-(methyl { [3-(methoxyl group) phenyl] sulfonyl } amino) ethyl]-3,4-two (methoxyl group) benzsulfamide;11) n-{2-[{[3,4-two (methoxyl group) phenyl] sulfonyl } (methyl) amino] ethyl }-3-fluoro-n-methyl-4-(methoxyl group) benzsulfamide;12) n-{2-[{[3,4-two (methoxyl group) phenyl] sulfonyl } (methyl) amino] ethyl }-n, 4-dimethyl-3,4-dihydro-2h-1,4-benzoxazine-7-sulfonamide;13) n-{2-[{[3,4-two (methoxyl group) phenyl] sulfonyl } (methyl) amino] ethyl }-n-methyl-2,3-dihydro-1,4-benzo dioxine-6-sulfonamide;14) n, n '-1,2-second two bases two [n-methyl-3,4-two (methoxyl group) benzsulfamide];15) n-methyl-n-[2-(methyl { [4-(methoxyl group) phenyl] sulfonyl } amino) ethyl]-3,4-two (methoxyl group) benzsulfamide;16) n-(1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-the 3-pyrrolidinyl)-8-quinoline sulfonamide;17) (2r, 6r)-1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-lupetazin;18) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,5-lupetazin;19) (2s)-1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2-methyl piperazine;20) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-cis-lupetazin;21) (2s, 6s)-1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-lupetazin;22) anti-form-1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,5-lupetazin;23) 1,3-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2-imidazolidinone;24) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2-cyclohexyl piperazine;25) n-(1-{[3,4-two (methoxyl group) phenyl] sulfonyl six hydrogen-1h-azepine -3-yl)-3,4-two (methoxyl group) benzsulfamide; 26) n-[2-({ [3,4-two (methoxyl group) phenyl] sulfonyl } amino) ethyl]-3-methyl-4-(methoxyl group) benzsulfamide;27) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,3-piperazinedione;28) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,3-piperazinedione;29) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2-methyl piperazine;30) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-(4-(methoxyl group)-3-[(trifluoromethyl) and the oxygen base] phenyl } sulfonyl) six hydrogen-1h-1, the 4-diaza 31) n-methyl-n-{2-[methyl ({ 4-(methoxyl group)-3[(trifluoromethyl) oxygen base] phenyl } sulfonyl) amino] ethyl }-3,4-two (methoxyl group) benzsulfamide;32) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-{[3-fluoro-4-(methoxyl group) phenyl] sulfonyl }-2,6-cis-lupetazin;33) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-cis-dimethyl-4-{[3-(methoxyl group) phenyl] sulfonyl } piperazine;34) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-cis-dimethyl-4-{[4-(1,3-oxazole-5-yl) phenyl] sulfonyl } piperazine;35) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-cis-dimethyl-4-{[4-(methoxyl group) phenyl] sulfonyl } piperazine;36) 4-{[3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-cis-dimethyl-1-(4-(methoxyl group)-3-[(trifluoromethyl) and the oxygen base] phenyl } sulfonyl) piperazine;37) 6-[(4-{[3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-cis-dimethyl-1-piperazinyl) sulfonyl]-the 2h-chromen-2-one;38) 5-[(4-{[3,4-two (methoxyl group) phenyl] sulfonyl }-2,6-cis-dimethyl-1-piperazinyl) sulfonyl]-2-(methoxyl group) phenol;39) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,3,5-tri methyl piperazine;40) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,3-lupetazin;41) 1-{[3,4-two (methoxyl group) phenyl] sulfonyl }-4-{[3-ethyl-4-(methoxyl group) phenyl] sulfonyl } six hydrogen-1h-1, the 4-diaza 42) n-[2-({ [3,4-two (methoxyl group) phenyl] sulfonyl } amino) ethyl]-n-methyl-3,4-two (methoxyl group) benzsulfamide;43) n-{2-[{[3,4-two (methoxyl group) phenyl] sulfonyl } (methyl) amino] ethyl }-n-methyl-3-ethyl-4-(methoxyl group) benzsulfamide;44) n, n '-1,2-glyceryl two [n-methyl-3,4-two (methoxyl group) benzsulfamide];45) (2r, 5s)-1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2,5-diethyl piperazine;46) 1,4-two { [3,4-two (methoxyl group) phenyl] sulfonyl }-2-et...
화합물본 발명은 일반적으로 신규한 치료 화합물 및 AXOr 109 작용제, 및 이의 제조 방법 및 용도에 관한 것이다.1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[3-플루오로-4-(메틸옥시)페닐]설포닐}피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[4-(1,3-옥사졸-5-일)페닐]설포닐}피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[4-메틸-2-(메틸옥시)페닐]설포닐}피페라진; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-[(2-클로로-6-메틸페닐)설포닐]피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[4-(메틸옥시)페닐]설포닐}피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[3-플루오로-4-(메틸옥시)페닐]설포닐}헥사히드로-1H-1,4-디아제핀; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-(2,3-디히드로-1,4-벤조디옥신-6-일설포닐)헥사히드로-1H-1,4-디아제핀; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}헥사히드로-1H-1,4-디아제핀; N-메틸-N-[2-(메틸{[3-(메틸옥시)페닐]설포닐}아미노)에틸]-3,4-비스(메틸옥시)벤젠설폰아미드; N-{2-[{[3,4-비스(메틸옥시)페닐]설포닐}(메틸)아미노]에틸}-3-플루오로-N-메틸-4-(메틸옥시)벤젠설폰아미드; N-{2-[{[3,4-비스(메틸옥시)페닐]설포닐}(메틸)아미노]에틸}-N,4-디메틸-3,4-디히드로-2H-1,4-벤즈옥사진-7-설폰아미드; N-{2-[{[3,4-비스(메틸옥시)페닐]설포닐}(메틸)아미노]에틸}-N-메틸-2,3-디히드로-1,4-벤조디옥신-6-설폰아미드; N,N'-1,2-에탄디일비스[N-메틸-3,4-비스(메틸옥시)벤젠설폰아미드]; N-메틸-N-[2-(메틸{[4-(메틸옥시)페닐]설포닐}아미노)에틸]-3,4-비스(메틸옥시)벤젠설폰아미드; N-(1-{[3,4-비스(메틸옥시)페닐]설포닐}-3-피롤리디닐)-8-퀴놀린설폰아미드; (2R,6R)-1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-디메틸피페라진; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,5-디메틸피페라진; (2S)-1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2-메틸피페라진; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-시스-디메틸피페라진; (2S,6S)-1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-디메틸피페라진; 트랜스-1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,5-디메틸피페라진; 1,3-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2-이미다졸리디논; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2-시클로헥실피페라진; N-(1-{[3,4-비스(메틸옥시)페닐]설포닐}헥사히드로-1H-아제핀-3-일)-3,4-비스(메틸옥시)벤젠설폰아미드; N-[2-({[3,4-비스(메틸옥시)페닐]설포닐}아미노)에틸]-3-메틸-4-(메틸옥시)벤젠설폰아미드; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,3-피페라진디온; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,3-피페라진디온; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2-메틸피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-({4-(메틸옥시)-3-[(트리플루오로메틸)옥시]페닐}설포닐)헥사히드로-1H-1,4-디아제핀; N-메틸-N-{2-[메틸({4-(메틸옥시)-3[(트리플루오로메틸)옥시]페닐}설포닐)아미노]에틸}-3,4-비스(메틸옥시)벤젠설폰아미드; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[3-플루오로-4-(메틸옥시)페닐]설포닐}-2,6-시스-디메틸피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-시스-디메틸-4-{[3-(메틸옥시)페닐]설포닐}피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-시스-디메틸-4-{[4-(1,3-옥사졸-5-일)페닐]설포닐}피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-시스-디메틸-4-{[4-(메틸옥시)페닐]설포닐}피페라진; 4-{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-시스-디메틸-1-({4-(메틸옥시)-3-[(트리플루오로메틸)옥시]페닐}설포닐)피페라진; 6-[(4-{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-시스-디메틸-1-피페라지닐)설포닐]-2H-크로멘-2-온; 5-[(4-{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-시스-디메틸-1-피페라지닐)설포닐]-2-(메틸옥시)페놀; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,3,5-트리메틸피페라진; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,3-디메틸피페라진; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[3-에틸-4-(메틸옥시)페닐]설포닐}헥사히드로-1H-1,4-디아제핀; N-[2-({[3,4-비스(메틸옥시)페닐]설포닐}아미노)에틸]-N-메틸-3,4-비스(메틸옥시)벤젠설폰아미드; N-{2-[{[3,4-비스(메틸옥시)페닐]설포닐}(메틸)아미노]에틸}-N-메틸-3-에틸-4-(메틸옥시)벤젠설폰아미드; N,N'-1,2-프로판디일비스[N-메틸-3,4-비스(메틸옥시)벤젠설폰아미드]; (2R,5S)-1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,5-디에틸피페라진; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2-에틸-5-메틸피페라진; (2S,5S)-1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,5-디메틸피페라진; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-5,5-디메틸-2-피페라지논; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2-메틸헥사히드로-1H-1,4-디아제핀; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,2-디메틸피페라진; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}헥사히드로-6H-1,4-디아제핀-6-온; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-6-플루오로헥사히드로-1H-1,4-디아제핀; 1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-6,6-디플루오로헥사히드로-1H-1,4-디아제핀; (2R,6S)-1,4-비스{[3,4-비스(메틸옥시)페닐]설포닐}-2,6-디메틸피페라진; N,N'-2,3-부탄디일비스[N-메틸-3,4-비스(메틸옥시)벤젠설폰아미드]; N-(1-{[3,4-비스(메틸옥시)페닐]설포닐}-3-피롤리디닐)-3,4-비스(메틸옥시)-N-프로필벤젠설폰아미드; N-(1-{[3,4-비스(메틸옥시)페닐]설포닐}-3-피롤리디닐)-3,4-비스(메틸옥시)-N-(2-메틸프로필)벤젠설폰아미드; N-(1-{[3,4-비스(메틸옥시)페닐]설포닐}-3-피롤리디닐)-N-(시클로부틸메틸)-3,4-비스(메틸옥시)벤젠설폰아미드; N-((3R)-1-{[3,4-비스(메틸옥시)페닐]설포닐}-3-피롤리디닐)-3,4-비스(메틸옥시)-N-프로필벤젠설폰아미드; N-((3R)-1-{[3,4-비스(메틸옥시)페닐]설포닐}-3-피롤리디닐)-N-에틸-3,4-비스(메틸옥시)벤젠설폰아미드; N-((3S)-1-{[3,4-비스(메틸옥시)페닐]설포닐}-3-피롤리디닐)-3,4-비스(메틸옥시)-N-프로필벤젠설폰아미드; N-((3S)-1-{[3,4-비스(메틸옥시)페닐]설포닐}-3-피롤리디닐)-N-에틸-3,4-비스(메틸옥시)벤젠설폰아미드; 4-[((2S,5S)-4-{[3,4-비스(메틸옥시)페닐]설포닐}-2,5-디메틸-1-피페라지닐)설포닐]-2-(메틸옥시)페닐 메탄설포네이트; 1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[3-에틸-4-(메틸옥시)페닐]설포닐}피페라진; N-{2-[{[3,4-비스(메틸옥시)페닐]설포닐}(메틸)아미노]에틸}-N,1,3-트리메틸-2-옥소-2,3-디히드로-1H-벤즈이미다졸-5-설폰아미드; N-[2-({[3,4-비스(메틸옥시)페닐]설포닐}아미노)-1-메틸에틸]-N-메틸-3,4-비스(메틸옥시)벤젠설폰아미드; (2S,5S)-1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[3-플루오로-4-(메틸옥시)페닐]설포닐}-2,5-디메틸피페라진; (2S,5S)-1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-{[3-에틸-4-(메틸옥시)페닐 ]설포닐}-2,5-디메틸피페라진; 8-[((2S,5S)-4-{[3,4-비스(메틸옥시)페닐]설포닐}-2,5-디메틸-1-피페라지닐)설포닐]퀴놀린; (2S,5S)-1-(1,3-벤조디옥솔-5-일설포닐)-4-{[3,4-비스(메틸옥시)페닐]설포닐}-2,5-디메틸피페라진; (2S,5S)-1-{[3,4-비스(메틸옥시)페닐]설포닐}-4-(2,3-디히드로-1,4-벤조디옥신-6-일설포닐)-2,5-디메틸피페라진; (2S,5S)-1-{[3,4-비스(메틸옥시)페닐]설포닐}-2,5-디메틸-4-{[4-(메틸옥시)페닐]설포닐}피페라진; N-{2-[{[3,4-비스(메틸옥시)페닐]설포닐}(메틸)아미노]에틸}-N-메틸-3,4-디히드로-2H-1,5-벤조디옥세핀-7-설폰아미드; N,N'-(2S)-1,2-프로판디일비스[N-에틸-3,4-비스(메틸옥시)벤젠설폰아미드]; N-{2-[{[3,4-비스(메틸옥시)페닐]설포닐}(2-부텐-1-일)아미노]에틸}-N-메틸-3,4-비스(메틸옥시)벤젠설폰아미드로부터 선택된 화합물, 또는 이의 염 또는 용매화물을 포함하는 약제 조성물.