Hydroxybiphenyl carboxylic acids and derivatives, method for producing the same and their useThe invention relates to substituted hydroxybiphenyls, the derivatives and the physiologically acceptable salts thereof. The invention relates to the compounds of formula (I), wherein the substituents R1, R2 and A are defined as indicated, and to the physiologically acceptable salts thereof. The inventive compounds are suitable e.g. as hypoglycemic drugs and as drugs for use in the prevention and treatment of diabetes.The compound of formula i and its physiology salt that can tolerate,implication wherein isr1:-(c 1-c 6)-alkyl ,-(c 1-c 4)-alkyl-o-(c 1-c 4)-alkyl ,-(c 2-c 6)-alkenyl ,-(c 3-c 8)-cycloalkyl ,-aryl ,-(c 1-c 6)-alkyl-aryl ,-(c 2-c 6)-alkenyl-aryl ,-(c 1-c 6)-alkyl-cycloalkyl ,-(c 2-c 6)-alkenyl-cycloalkyl, wherein alkyl, alkenyl, aryl and cycloalkyl can be replaced by following groups: f, cl, br, i, cf 3, no 2, n 3, cn, cooh, coo (c 1-c 6) alkyl, conh 2, conh (c 1-c 6) alkyl, con[(c 1-c 6) alkyl] 2, cycloalkyl, (c 2-c 6)-alkenyl, (c 2-c 6)-alkynyl, o-(c 1-c 6)-alkyl o-co-(c 1-c 6)-alkyl, o-co-(c 1-c 6)-aryl, o-co-(c 1-c 6)-heterocycle; po 3h 2, so 3h, so 2-nh 2, so 2nh (c 1-c 6)-alkyl, so 2n[(c 1-c 6)-alkyl] 2, s-(c 1-c 6)-alkyl, s-(ch 2) n-aryl, s-(ch 2) n-heterocycle, so-(c 1-c 6)-alkyl, so-(ch 2) n-aryl, so-(ch 2) n-heterocycle, so 2-(c 1-c 6)-alkyl, so 2-(ch 2) n-aryl, so 2-(ch 2) n-heterocycle, so 2-nh (ch 2) n-aryl, so 2-nh (ch 2) n-heterocycle, so 2-n (c 1-c 6)-alkyl) (ch 2) n-aryl, so 2-n (c 1-c 6)-alkyl) (ch 2) n-heterocycle, so 2-n ((ch 2) n-aryl) 2, so 2-n ((ch 2) n-(heterocycle) 2, wherein n is 0-6, and aryl or heterocyclic radical can be by f, cl, br, oh, cf 3, no 2, cn, ocf 3, o-(c 1-c 6)-alkyl, (c 1-c 6)-alkyl, nh 2to polysubstituted twice; c (nh) (nh 2), nh 2, nh-(c 1-c 6)-alkyl, n ((c 1-c 6)-alkyl) 2, nh (c 1-c 7)-acyl group, nh-co-(c 1-c 6)-alkyl, nh-coo-(c 1-c 6)-alkyl, nh-co-aryl, nh-co-heterocycle, nh-coo-aryl, nh-coo-heterocycle, nh-co-nh-(c 1-c 6)-alkyl, nh-co-nh-aryl, nh-co-nh-heterocycle, n (c 1-c 6)-alkyl-co-(c 1-c 6)-alkyl, n (c 1-c 6)-alkyl-coo-(c 1-c 6)-alkyl, n (c 1-c 6)-alkyl-co-aryl, n (c 1-c 6)-alkyl-co-heterocycle, n (c 1-c 6)-alkyl-coo-aryl, n (c 1-c 6)-alkyl-coo-heterocycle, n (c 1-c 6)-alkyl-co-nh-(c 1-c 6)-alkyl), n (c 1-c 6)-alkyl-co-nh-aryl, n (c 1-c 6)-alkyl-co-nh-heterocycle, n ((c 1-c 6)-alkyl)-co-n-(c 1-c 6)-alkyl) 2, n ((c 1-c 6)-alkyl)-co-n ((c 1-c 6)-alkyl)-aryl, n ((c 1-c 6)-alkyl)-co-n ((c 1-c 6)-alkyl)-heterocycle, n ((c 1-c 6)-alkyl)-co-n-(aryl) 2, n ((c 1-c 6)-alkyl)-co-n-(heterocycle) 2, n (aryl)-co-(c 1-c 6)-alkyl, n (heterocycle)-co-(c 1-c 6)-alkyl, n (aryl)-coo-(c 1-c 6)-alkyl, n (heterocycle)-coo-(c 1-c 6)-alkyl, n (aryl)-co-aryl, n (heterocycle)-co-aryl, n (aryl)-coo-aryl, n (heterocycle)-coo-aryl, n (aryl)-co-nh-(c 1-c 6)-alkyl), n (heterocycle)-co-nh-(c 1-c 6)-alkyl), n (aryl)-co-nh-aryl, n (heterocycle)-co-nh-aryl, n (aryl)-co-n-(c 1-c 6)-alkyl) 2, n (heterocycle)-co-n-(c 1-c 6)-alkyl) 2, n (aryl)-co-n ((c 1-c 6)-alkyl)-aryl, n (heterocycle)-co-n ((c 1-c 6)-alkyl)-aryl, n (aryl)-co-n-(aryl) 2, n (heterocycle)-co-n-(aryl) 2, aryl, o-(ch 2) n-aryl, o-(ch 2) n-heterocycle, wherein n is 0-6, wherein aryl or heterocyclic radical can be by f, cl, br, i, oh, cf 3, no 2, cn, ocf 3, o-(c 1-c 6)-alkyl, (c 1-c 6)-alkyl, nh 2, nh (c 1-c 6)-alkyl, n ((c 1-c 6)-alkyl) 2, so 2-ch 3, cooh, coo-(c 1-c 6)-alkyl, conh 2replace 1 to 3 time; r2:-(c 1-c 6)-alkyl ,-(c 1-c 4)-alkyl-o-(c 1-c 4)-alkyl ,-(c 2-c 6)-alkenyl ,-(c 3-c 8)-cycloalkyl ,-(c 1-c 6)-alkyl-aryl ,-(c 2-c 6)-alkenyl-aryl, heterocycle ,-(c 1-c 6)-alkyl-heterocycle ,-(c 2-c 6)-alkenyl-heterocycle ,-(c 1-c 6)-alkyl-cycloalkyl ,-(c 2-c 6)-alkenyl-cycloalkyl, wherein alkyl, alkenyl, aryl, heterocyclic radical and cycloalkyl can be replaced by following groups: f, cl, br, i, cf 3, no 2, n 3, cn, cooh, coo (c 1-c 6) alkyl, conh 2, conh (c 1-c 6) alkyl, con[(c 1-c 6) alkyl] 2, cycloalkyl, (c 2-c 6)-alkenyl, (c 2-c 6)-alkynyl, o-(c 1-c 6)-alkyl o-co-(c 1-c 6)-alkyl, o-co-(c 1-c 6)-aryl, o-co-(c 1-c 6)-heterocycle; po 3h 2, so 3h, so 2-nh 2, so 2nh (c 1-c 6)-alkyl, so 2n[(c 1-c 6)-alkyl] 2, s-(c 1-c 6)-alkyl, s-(ch 2) n-aryl, s-(ch 2) n-heterocycle, so-(c 1-c 6)-alkyl, so-(ch 2) n-aryl, so-(ch 2) n-bar ring, so 2-(c 1-c 6)-alkyl, so 2-(ch 2) n-aryl, so 2-(ch 2) n-heterocycle, so 2-nh (ch 2) n-aryl, so 2-nh (ch 2) n-heterocycle, so 2-n (c 1-c 6)-alkyl) (ch 2) n-aryl, so 2-n (c 1-c 6)-alkyl) (ch 2) n-heterocycle, so 2-n ((ch 2) n-aryl) 2, so 2-n ((ch 2) n-(heterocycle) 2, wherein n is 0-6, and aryl or heterocyclic radical can be by f, cl, br, oh, cf 3, no 2, cn, ocf 3, o-(c 1-c 6)-alkyl, (c 1-c 6)-alkyl, nh 2to polysubstituted twice; c (nh) (nh 2), nh 2, nh-(c 1-c 6)-alkyl, n ((c 1-c 6)-alkyl) 2, nh (c 1-c 7)-acyl group, nh-co-(c 1-c 6)-alkyl, nh-coo-(c 1-c 6)-alkyl, nh-co-aryl, nh-co-heterocycle, nh-coo-aryl, nh-coo-heterocycle, nh-co-nh-(c 1-c 6)-alkyl, nh-co-nh-aryl, nh-co-nh-heterocycle, n (c 1-c 6)-alkyl-co-(c 1-c 6)-alkyl, n (c 1-c 6)-alkyl-coo-(c 1-c 6)-alkyl, n (c 1-c 6)-alkyl-co-aryl, n (c 1-c 6)-alkyl-co-heterocycle, n (c 1-c 6)-alkyl-coo-aryl, n (c 1-c 6)-alkyl-coo-heterocycle, n (c 1-c 6)-alkyl-co-nh-(c 1-c 6)-alkyl), n (c 1-c 6)-alkyl-co-nh-aryl, n (c 1-c 6)-alkyl-co-nh-heterocycle, n ((c 1-c 6)-alkyl)-co-n-(c 1-c 6)-alkyl) 2, n ((c 1-c 6)-alkyl)-co-n ((c 1-c 6)-alkyl)-aryl, n ((c 1-c 6)-alkyl)-co-n ((c 1-c 6)-alkyl)-heterocycle, n ((c 1-c 6)-alkyl)-co-n-(aryl) 2, n ((c 1-c 6)-alkyl)-co-n-(heterocycle)...
하이드록시비페닐 카복실산과 이의 유도체, 이들의제조방법 및 이들의 용도본 발명은 치환된 하이드록시비페닐, 및 이의 유도체 및 생리학적으로 허용되는 염에 관한 것이다. 본 발명은 화학식 I의 화합물 및 생리학적으로 허용되는 이의 염에 관한 것이다. 본 발명은, 예를 들면, 혈당저하제로서, 그리고 당뇨병의 예방 및 치료에 유용한 약제로서 적합하다. 화학식 I  위의 화학식 I에서, R1, R2 및 A는 본원 명세서에서 정의한 바와 같다. 화학식 I의 화합물 및 생리학적으로 허용되는 이의 염. 화학식 I [이미지] 위의 화학식 I에서, R1은 -(C1-C6)-알킬, -(C1-C4)-알킬-O-(C1-C4)-알킬, -(C2-C6)-알케닐, -(C3-C8)-사이클로알킬, -아릴, -(C1-C6)-알킬-아릴, -(C2-C6)-알케닐-아릴, -(C1-C6)-알킬-사이클로알킬, -(C2-C6)-알케닐-사이클로알킬[여기서, 알킬, 알케닐, 아릴 및 사이클로알킬 라디칼은 F, Cl, Br, I, CF3, NO2, N3, CN, COOH, COO(C1-C6)알킬, CONH2, CONH(C1-C6)알킬, CON[(C1-C6)알킬]2, 사이클로알킬, (C2-C6)-알케닐, (C2-C6)-알키닐, O-(C1-C6)-알킬 O-CO-(C1-C6)-알킬, O-CO-(C1-C6)-아릴 또는 O-CO-(C1-C6)-헤테로사이클로 치환될 수 있다]; PO3H2, SO3H, SO2-NH2, SO2NH(C1-C6)-알킬, SO2N[(C1-C6)-알킬]2, S-(C1-C6)-알킬, S-(CH2)n-아릴, S-(CH2)n-헤테로사이클, SO-(C1-C6)-알킬, SO-(CH2)n-아릴, SO-(CH2)n-헤테로사이클, SO2-(C1-C6)-알킬, SO2-(CH2)n-아릴, SO2-(CH2)n-헤테로사이클, SO2-NH(CH2)n-아릴, SO2-NH(CH2)n-헤테로사이클, SO2-N((C1-C6)-알킬)(CH2)n-아릴, SO2-N((C1-C6)-알킬)(CH2)n-헤테로사이클, SO2-N((CH2)n-아릴)2, SO2-N((CH2)n-(헤테로사이클))2[여기서, n은 0 내지 6일 수 있고, 아릴 라디칼 또는 헤테로사이클릭 라디칼은 F, Cl, Br, OH, CF3, NO2, CN, OCF3, O-(C1-C6)-알킬, (C1-C6)-알킬 또는 NH2로 1회 또는 2회 치환될 수 있다]; C(NH)(NH2), NH2, NH-(C1-C6)-알킬, N((C1-C6)-알킬)2, NH(C1-C7)-아실, NH-CO-(C1-C6)-알킬, NH-COO-(C1-C6)-알킬, NH-CO-아릴, NH-CO-헤테로사이클, NH-COO-아릴, NH-COO-헤테로사이클, NH-CO-NH-(C1-C6)-알킬, NH-CO-NH-아릴, NH-CO-NH-헤테로사이클, N(C1-C6)-알킬-CO-(C1-C6)-알킬, N(C1-C6)-알킬-COO-(C1-C6)-알킬, N(C1-C6)-알킬-CO-아릴, N(C1-C6)-알킬-CO-헤테로사이클, N(C1-C6)-알킬-COO-아릴, N(C1-C6)-알킬-COO-헤테로사이클, N(C1-C6)-알킬-CO-NH-(C1-C6)-알킬, N(C1-C6)-알킬-CO-NH-아릴, N(C1-C6)-알킬-CO-NH-헤테로사이클, N((C1-C6)-알킬)-CO-N-((C1-C6)-알킬)2, N((C1-C6)-알킬)-CO-N((C1-C6)-알킬)-아릴, N((C1-C6)-알킬)-CO-N((C1-C6)-알킬)-헤테로사이클, N((C1-C6)-알킬)-CO-N-(아릴)2, N((C1-C6)-알킬)-CO-N-(헤테로사이클)2, N(아릴)-CO-(C1-C6)-알킬, N(헤테로사이클)-CO-(C1-C6)-알킬, N(아릴)-COO-(C1-C6)-알킬, N(헤테로사이클)-COO-(C1-C6)-알킬, N(아릴)-CO-아릴, N(헤테로사이클)-CO-아릴, N(아릴)-COO-아릴, N(헤테로사이클)-COO-아릴, N(아릴)-CO-NH-(C1-C6)-알킬, N(헤테로사이클)-CO-NH-(C1-C6)-알킬, N(아릴)-CO-NH-아릴, N(헤테로사이클)-CO-NH-아릴, N(아릴)-CO-N-((C1-C6)-알킬)2, N(헤테로사이클)-CO-N-((C1-C6)-알킬)2, N(아릴)-CO-N((C1-C6)-알킬)-아릴, N(헤테로사이클)-CO-N((C1-C6)-알킬)-아릴, N(아릴)-CO-N-(아릴)2, N(헤테로사이클)-CO-N-(아릴)2, 아릴, O-(CH2)n-아릴, O-(CH2)n-헤테로사이클[여기서, n은 0 내지 6일 수 있고, 아릴 라디칼 또는 헤테로사이클릭 라디칼은 F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-(C1-C6)-알킬, (C1-C6)-알킬, NH2, NH(C1-C6)-알킬, N((C1-C6)-알킬)2, SO2-CH3, COOH, COO-(C1-C6)-알킬 또는 CONH2로 1회 내지 3회 치환될 수 있다]이고, R2는 -(C1-C6)-알킬, -(C1-C4)-알킬-O-(C1-C4)-알킬, -(C2-C6)-알케닐, -(C3-C8)-사이클로알킬, -(C1-C6)-알킬-아릴, -(C2-C6)-알케닐-아릴, 헤테로사이클, -(C1-C6)-알킬-헤테로사이클, -(C2-C6)-알케닐-헤테로사이클, -(C1-C6)-알킬-사이클로알킬, -(C2-C6)-알케닐-사이클로알킬[여기서, 알킬, 알케닐, 아릴, 헤테로사이클릴 및 사이클로알킬 라디칼은 F, Cl, Br, I, CF3, NO2, N3, CN, COOH, COO(C1-C6)알킬, CONH2, CONH(C1-C6)알킬, CON[(C1-C6)알킬]2, 사이클로알킬, (C2-C6)-알케닐, (C2-C6)-알키닐, O-(C1-C6)-알킬 O-CO-(C1-C6)-알킬, O-CO-(C1-C6)-아릴 또는 O-CO-(C1-C6)-헤테로사이클로 치환될 수 있다]; PO3H2, SO3H, SO2-NH2, SO2NH(C1-C6)-알킬, SO2N[(C1-C6)-알킬]2, S-(C1-C6)-알킬, S-(CH2)n-아릴, S-(CH2)n-헤테로사이클, SO-(C1-C6)-알킬, SO-(CH2)n-아릴, SO-(CH2)n-헤테로사이클, SO2-(C1-C6)-알킬, SO2-(CH2)n-아릴, SO2-(CH2)n-헤테로사이클, SO2-NH(CH2)n-아릴, SO2-NH(CH2)n-헤테로사이클, SO2-N((C1-C6)-알킬)(CH2)n-아릴, SO2-N((C1-C6)-알킬)(CH2)n-헤테로사이클, SO2-N((CH2)n-아릴)2, SO2-N((CH2)n-(헤테로사이클))2[여기서, n은 0 내지 6일 수 있고, 아릴 라디칼 또는 헤테로사이클릭 라디칼은 F, Cl, Br, OH, CF3, NO2, CN, OCF3, O-(C1-C6)-알킬, (C1-C6)-알킬 또는 NH2로 1회 또는 2회 치환될 수 있다]; C(NH)(NH2), NH2, NH-(C1-C6)-알킬, N((C1-C6)-알킬)2, NH(C1-C7)-아실, NH-CO-(C1-C6)-알킬, NH-COO-(C1-C6)-알킬, NH-CO-아릴, NH-CO-헤테로사이클, NH-COO-아릴, NH-COO-헤테로사이클, NH-CO-NH-(C1-C6)-알킬, NH-CO-NH-아릴, NH-CO-NH-헤테로사이클, N(C1-C6)-알킬-CO-(C1-C6)-알킬, N(C1-C6)-알킬-COO-(C1-C6)-알킬, N(C1-C6)-알킬-CO-아릴, N(C1-C6)-알킬-CO-헤테로사이클, N(C1-C6)-알킬-COO-아릴, N(C1-C6)-알킬-COO-헤테로사이클, N(C1-C6)-알킬-CO-NH-(C1-C6)-알킬, N(C1-C6)-알킬-CO-NH-아릴, N(C1-C6)-알킬-CO-NH-헤테로사이클, N((C1-C6)-알킬)-CO-N-((C1-C6)-알킬)2, N((C1-C6)-알킬)-CO-N((C1-C6)-알킬)-아릴, N((C1-C6)-알킬)-CO-N((C1-C6)-알킬)-헤테로사이클, N((C1-C6)-알킬)-CO-N-(아릴)2, N((C1-C6)-알킬)-CO-N-(헤테로사이클)2, N(아릴)-CO-(C1-C6)-알킬, N(헤테로사이클)-CO-(C1-C6)-알킬, N(아릴)-COO-(C1-C6)-알킬, N(헤테로사이클)-COO-(C1-C6)-알킬, N(아릴)-CO-아릴, N(헤테로사이클)-CO-아릴, N(아릴)-COO-아릴, N(헤테로사이클)-COO-아릴, N(아릴)-CO-NH-(C1-C6)-알킬, N(헤테로사이클)-CO-NH-(C1-C6)-알킬, N(아릴)-CO-NH-아릴, N(헤테로사이클)-CO-NH-아릴, N(아릴)-CO-N-((C1-C6)-알킬)2, N(헤테로사이클)-CO-N-((C1-C6)-알킬)2, N(아릴)-CO-N((C1-C6)-알킬)-아릴, N(헤테로사이클)-CO-N((C1-C6)-알킬)-아릴, N(아릴)-CO-N-(아릴)2, N(헤테로사이클)-CO-N-(아릴)2, 아릴, O-(CH2)n-아릴, O-(CH2)n-헤테로사이클[여기서, n은 0 내지 6일 수 있고, 아릴 라디칼 또는 헤테로사이클릭 라디칼은 F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-(C1-C6)-알킬, (C1-C6)-알킬, NH2, NH(C1-C6)-알킬, N((C1-C6)-알킬)2, SO2-CH3, COOH, COO-(C1-C6)-알킬 또는 CONH2로 1회 내지 3회 치환될 수 있다]이고, A는 결합, O, NH 또는 S이다.