Derivatives of [1, 2, 4]-triazolo-[4, 3-A]-pyridine as p38 MAP kinase inhibitorsThis invention relates to compounds selected in the group consisting of compounds of formula (la) to (Id) and compositions, that are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.Compound, is selected from:1-[the 3-tertiary butyl-1'-(2-[1,4] oxazepine suberane-4-base-ethyl)-1'h [1,4'] join pyrazoles-5-base]-3-{ (4-[3-2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;the 1-{3-tertiary butyl-1'-[2-(4-thyl-piperazin-1-base)-ethyl]-1'h-[1,4'] join pyrazoles-5-base }-3-{ (4-[3-((s)-2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;the 1-{3-tertiary butyl-1'-[2-(4-hydroxy-piperdine-1-base)-ethyl]-1'h-[1,4'] join pyrazoles-5-base }-3-{4-[3-2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-(the 3-tertiary butyl-1'-{2-[(2-methox-etlayl)-methyl-amino]-ethyl }-1'h-[1,4'] join pyrazoles-5-base)-3--4-[3-(-2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea;1-[the 3-tertiary butyl-1'-(2-piperidin-1-yl-ethyl)-1'h-[1,4'] join pyrazoles-5-base]-3-{4-[3-2,6-dimethyi-pineridin-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-[the 3-tertiary butyl-1'-(2-[1,4] oxazepine suberane-4-base-ethyl)-1'h-[1,4'] join pyrazoles-5-base]-3-{4-[3-2,6-dimethyi-pineridin-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-[the 3-tertiary butyl-1'-(2-dimethylamino-ethyl)-1'h-[isosorbide-5-nitrae '] joins pyrazoles-5-base]-3-[4-(3-dimethylamino-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base)-1,2,3,4-tetrahydrochysene-naphthalene-1-base]-urea formate;1-[the 3-tertiary butyl-1'-(2-dimethylamino-ethyl)-1'h [1,4'] join pyrazoles-5-base]-3-{4-[3-(2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-[the 3-tertiary butyl-1'-(3-dimethylamino-propyl)-1'h-[1,4'] join pyrazoles-5-base]-3-{4-[3-(2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;the 1-{3-tertiary butyl-1'-[3-(4-thyl-piperazin-1-base)-propyl group]-1'h-[1,4'] join pyrazoles-5-base }-3-{4-[3-2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-[the 3-tertiary butyl-1'-(2-dimethylamino-ethyl)-1'h-[1,3'] join pyrazoles-5-base]-3-{4-[3-(2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-[the 3-tertiary butyl-1'-(2-dimethylamino-ethyl)-1'h-[1,3'] join pyrazoles-5-base]-3-{4-[3-(2,6-dimethyi-pineridin-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-[the 5-tertiary butyl-2-(2-dimethylamino-ethyl)-2h-pyrazole-3-yl]-3-{4-[3-(2,6-dimethyi-pineridin-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-naphthane-1-base }-urea formate;the 1-{5-tertiary butyl-2-[5-(2-dimethylamino-ethoxy)-pyridin-3-yl]-2h-pyrazole-3-yl }-3-{4-[3-((2s, 6r)-2,6-dimethyi-pineridin-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;the 1-{5-tertiary butyl-2-[5-(2-dimethylamino-ethoxy)-pyridin-3-yl]-2h-pyrazole-3-yl }-3-{4-[3-(2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;the 1-{5-tertiary butyl-2-[6-(2-dimethylamino-ethoxy)-pyridine-2-base]-2h-pyrazole-3-yl }-3-{4-[3-(2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-[the 3-tertiary butyl-1'-(2-dimethylamino-ethyl)-1'h-[1,4'] join pyrazoles-5-base]-3-{-4-[3-(2,6-dichloro-phenyl)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-[the 3-tertiary butyl-1'-(2-dimethylamino-ethyl)-1'h-[isosorbide-5-nitrae '] joins pyrazoles-5-base]-3 [4-(3-sec.-propyl-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base)-1,2,3,4-tetrahydrochysene-naphthalene-1-base]-urea formate;1-[the 3-tertiary butyl-1'-(2-pyrrolidin-1-yl-ethyl)-1'h-[1,4'] join pyrazoles-5-base]-3-{4-[3-(2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;the 1-{3-tertiary butyl-1'-[2-(4-methoxy-piperidin-1-base)-ethyl]-1'h-[1,4'] join pyrazoles-5-base }-3-{4-[3-(2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base }-urea formate;1-(the 3-tertiary butyl-1'-{2-[(2-hydroxy-ethyl)-methyl-amino]-ethyl }-1'h-[1,4'] join pyrazoles-5-base)-3-{4-[3-(2-methyl-pi-1-base)-[1,2,4] triazolo [4,3-a] pyridine-6-base oxygen base]-1,2,3,4-tetrahydrochysene-naphthalene-1-base ...
P38 - MAP 키나아제 억제제로서 [1, 2, 4] 트리아졸로 [4, 3 - A] 피리딘의 유도체본 발명은, 특히 호흡기 질환의 치료에서 항염증제로서 유용한, p38 MAPK 억제제인, 식 (Ia) 내지 (Id)의 화합물 및 조성물로 이루어지는 군에서 선택되는 화합물에 관한 것이다.다음으로 이루어지는 군으로부터 선택되는 화합물:1-[3-tert-부틸-1'-(2-[1,4]옥사제판-4-일-에틸)-1'H[1,4']비피라졸릴-5-일]-3-{(4-[3-2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{3-tert-부틸-1'-[2-(4-메틸-피페라진-1-일)-에틸]-1'H-[1,4']비피라졸릴-5-일}-3-{(4-[3-((S)-2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{3-tert-부틸-1'-[2-(4-히드록시-피페리딘-1-일)-에틸]-1'H-[1,4']비피라졸릴-5-일}-3-{4-[3-2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-(3-tert-부틸-1'-{2-[(2-메톡시-에틸)-메틸-아미노]-에틸}-1'H-[1,4']비피라졸릴-5-일)-3--4-[3-(-2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아;1-[3-tert-부틸-1'-(2-피페리딘-1-일-에틸)-1'H-[1,4']비피라졸릴-5-일]-3-{4-[3-2,6-디메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-[1,4]옥사제판-4-일-에틸)-1'H-[1,4']비피라졸릴-5-일]-3-{4-[3-2,6-디메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-디메틸아미노-에틸)-1'H-[1,4']비피라졸릴-5-일]-3-[4-(3-디메틸아미노-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시)-1,2,3,4-테트라히드로-나프탈렌-1-일]-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-디메틸아미노-에틸)-1'H[1,4']비피라졸릴-5-일]-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(3-디메틸아미노-프로필)-1'H-[1,4']비피라졸릴-5-일]-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{3-tert-부틸-1'-[3-(4-메틸-피페라진-1-일)-프로필]-1'H-[1,4']비피라졸릴-5-일}-3-{4-[3-2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-디메틸아미노-에틸)-1'H-[1,3']비피라졸릴-5-일]-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-디메틸아미노-에틸)-1'H-[1,3']비피라졸릴-5-일]-3-{4-[3-(2,6-디메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[5-tert-부틸-2-(2-디메틸아미노-에틸)-2H-피라졸-3-일]-3-{4-[3-(2,6-디메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로나프탈렌-1-일}-우레아 포르메이트 염;1-{5-tert-부틸-2-[5-(2-디메틸아미노-에톡시)-피리딘-3-일]-2H-피라졸-3-일}-3-{4-[3-((2S,6R)-2,6-디메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{5-tert-부틸-2-[5-(2-디메틸아미노-에톡시)-피리딘-3-일]-2H-피라졸-3-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{5-tert-부틸-2-[6-(2-디메틸아미노-에톡시)-피리딘-2-일]-2H-피라졸-3-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-디메틸아미노-에틸)-1'H-[1,4']비피라졸릴-5-일]-3-{-4-[3-(2,6-디클로로-페닐)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-디메틸아미노-에틸)-1'H-[1,4']비피라졸릴-5-일]-3[4-(3-이소프로필-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시)-1,2,3,4-테트라히드로-나프탈렌-1-일]-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-피롤리딘-1-일-에틸)-1'H-[1,4']비피라졸릴-5-일]-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{3-tert-부틸-1'-[2-(4-메톡시-피페리딘-1-일)-에틸]-1'H-[1,4']비피라졸릴-5-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-(3-tert-부틸-1'-{2-[(2-히드록시-에틸)-메틸-아미노]-에틸}-1'H-[1,4']비피라졸릴-5-일)-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{3-tert-부틸-1'-[2-((S)-3-히드록시-피롤리딘-1-일)-에틸]-1'H-[1,4']비피라졸릴-5-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{3-tert-부틸-1'-[2-(3-메톡시-피롤리딘-1-일)-에틸]-1'H-[1,4']비피라졸릴-5-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{3-tert-부틸-1'-[2-(에틸-메틸-아미노)-에틸]-1'H-[1,4']비피라졸릴-5-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{3-tert-부틸-1'-[2-((S)-2-히드록시메틸-피롤리딘-1-일)-에틸]-1'H-[1,4']비피라졸릴-5-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염; 1-{3-tert-부틸-1'-[2-(5-메틸-2,5-디아자-비시클로[2.2.1]헵트-2-일)-에틸]-1'H-[1,4']비피라졸릴-5-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-디메틸아미노-에틸)-1'H-[1,4']비피라졸릴-5-일]-3-{4-[3-(2-히드록시메틸-피롤리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아;1-[3-tert-부틸-1'-(2-히드록시-에틸)-1'H-[1,4']비피라졸릴-5-일]-3-{4-[3-(1-메틸-피롤리딘-2-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-[3-tert-부틸-1'-(2-디메틸아미노-에틸)-1'H-[1,4']비피라졸릴-5-일]-3-{4-[3-(1-메틸-피롤리딘-2-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;1-{5-tert-부틸-2-[6-(2-디메틸아미노-에톡시)-피리다진-4-일]-2H-피라졸-3-일}-3-{4-[3-(2-메틸-피페리딘-1-일)-[1,2,4]트리아졸로[4,3-a]피리딘-6-일옥시]-1,2,3,4-테트라히드로-나프탈렌-1-일}-우레아 포르메이트 염;및 이들의 약제학적으로 허용가능한 염.