Poly aromatic sodium channel blockersPolyaromatic sodium channel blockers represented by the formula: ( I ) are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.The chemical compound of formula (i) representative:and racemic modification, enantiomer, diastereomer, tautomer, polymorph, pseudopolymorph and officinal salt, wherein:phenyl, low alkyl group-sulfenyl, phenyl-low alkyl group-sulfenyl, low alkyl group-sulfonyl or phenyl-low alkyl group-sulfonyl that x is hydrogen, halogen, trifluoromethyl, low alkyl group, do not replace or replace;the monokaryon aryl that y is hydrogen, hydroxyl, sulfydryl, lower alkoxy, low alkyl group-sulfenyl, halogen, low alkyl group, do not replace or replace, or-n (r 2) 2r 1be hydrogen or low alkyl group; each r 2be independently-r 7,-(ch 2) m-or 8,-(ch 2) m-nr 7r 10,-(ch 2) n(chor 8) (chor 8) n-ch 2or 8,-(ch 2ch 2o) m-r 8,-(ch 2ch 2o) m-ch 2ch 2nr 7r 10,-(ch 2) n-c (=o) nr 7r 10,-(ch 2) n-(z) g-r 7,-(ch 2) m-nr 10-ch 2(chor 8) (chor 8) n-ch 2or 8,-(ch 2) n-co 2r 7or r 3and r 4be hydrogen, low alkyl group, hydroxy lower alkyl, phenyl, (phenyl)-low alkyl group, (halogenophenyl)-low alkyl group, ((low alkyl group) phenyl)-low alkyl group, ((lower alkoxy) phenyl)-low alkyl group, (naphthyl)-low alkyl group or (pyridine radicals)-low alkyl group independently of one another, the perhaps group of formula a or formula b representative, prerequisite is that at least one is the group of formula a or formula b representative among r3 and the r4; formula a:-(c (r l) 2) o-x-(c (r l) 2) pa 1formula b:-(c (r l) 2) o-x-(c (r l) 2) pa 2a 1by at least one r 5the c that is replaced 7-c 15unit's aromatic carbon ring, and all the other substituent groups are r 6a 2by at least one r 5seven to the ten 5-membered aromatic family heterocycles that replaced, and all the other substituent groups are r 6, wherein said heteroaromatic comprises 1-4 hetero atom that is selected from o, n and s; each r lbe independently-r 7,-(ch 2) n-or 8,-o-(ch 2) m-or 8, -(ch 2) n-nr 7r 10、-o-(ch 2) m-nr 7r 10、 -(ch 2) n(chor 8)(chor 8) n-ch 2or 8、 -o-(ch 2) m(chor 8)(chor 8) n-ch 2or 8、-(ch 2ch 2o) m-r 8、 -o-(ch 2ch 2o) m-r 8、-(ch 2ch 2o) m-ch 2ch 2nr 7r 10、 -o-(ch 2ch 2o) m-ch 2ch 2nr 7r 10、-(ch 2) n-c(＝o)nr 7r 10、 -o-(ch 2) m-c(＝o)nr 7r 10、-(ch 2) n-(z) g-r 7、-o-(ch 2) m-(z) g-r 7、 -(ch 2) n-nr 10-ch 2(chor 8)(chor 8) n-ch 2or 8、 -o-(ch 2) m-nr 10-ch 2(chor 8)(chor 8) n-ch 2or 8、-(ch 2) n-co 2r 7、 -o-(ch 2) m-co 2r 7,-oso 3h ,-the o-glucosiduronic acid ,-the o-glucose, each o is 0 to 10 integer independently;each p is 0 to 10 integer independently;prerequisite is that the summation of o and p is 1 to 10 in each continuous chain;each x is o, nr independently 10, c (=o), choh, c (=n-r 10), chnr 7r 10or singly-bound; each r 5be independently oh ,-(ch 2) m-or 8,-o-(ch 2) m-or 8, -(ch 2) n-nr 7r 10、-o-(ch 2) m-nr 7r 10、 -(ch 2) n(chor 8)(chor 8) n-ch 2or 8、 -o-(ch 2) m(chor 8)(chor 8) n-ch 2or 8、-(ch 2ch 2o) m-r 8、 -o-(ch 2ch 2o) m-r 8、-(ch 2ch 2o) m-ch 2ch 2nr 7r 10、 -o-(ch 2ch 2o) m-ch 2ch 2nr 7r 10、-(ch 2) n-c(＝o)nr 7r 10、 -o-(ch 2) m-c(＝o)nr 7r 10、-(ch 2) n-(z) g-r 7、-o-(ch 2) m-(z) g-r 7、 -(ch 2) n-nr 10-ch 2(chor 8)(chor 8) n-ch 2or 8、 -o-(ch 2) m-nr 10-ch 2(chor 8)(chor 8) n-ch 2or 8、-(ch 2) n-co 2r 7、 -o-(ch 2) m-co 2r 7,-oso 3h ,-the o-glucosiduronic acid ,-the o-glucose, -(ch 2) n-co 2r 13、-het-(ch 2) m-co 2r 13、-(ch 2) n-(z) g-co 2r 13、 -het-(ch 2) m-(z) g-co 2r 13、-(ch 2) n-nr 10-(ch 2) m(chor 8) n-co 2r 13、 -het-(ch 2) m-nr 10-(ch 2) m(chor 8) n-co 2r 13、 -(ch 2) n-(chor 8) m-co 2r 13、-het-(ch 2) m-(chor 8) m-co 2r 13、 -(ch 2) n-(chor 8) m(z) g-co 2r 13、-het-(ch 2) n-(chor 8) m-(z) g-co 2r 13、 -(ch 2) n-(z) g-(ch 2) m-co 2r 13、-(ch 2) n-(z) g-(ch 2) m-co 2r 13、 -(ch 2) n-(z) g(chor 8) m-(z) g-co 2r 13、 -het-(ch 2) n-(z) g-(chor 8) m-(z) g-co 2r 13、 -(ch 2) n-conh-c(＝nr 13)-nr 13r 13、 -het-(ch 2) n-co-nh-c(＝nr 13)-nr 13r 13、 -(ch 2) n-(z) g-conh-c(＝nr 13)-nr 13r 13、 -het-(ch 2) n-(z) g-conh-c(＝nr 13)-nr 13r 13、 -(ch 2) n-nr 10-(ch 2) m(chor 8) n-conh-c(＝nr 13)-nr 13r 13、 -het-(ch 2) n-nr 10-(ch 2) m(chor 8) n-conh-c(＝nr 13)-nr 13r 13、 -(ch 2) n-(chor 8) m-conh-c(＝nr 13)-nr 13r 13、 -het-(ch 2) n-(chor 8) m-conh-c(＝nr 13)-nr 13r 13、 -(ch 2) n-(chor 8) m-(z) g-conh-c(＝nr 13)-nr 13r 13、 -het-(ch 2) n-(chor 8) m-(z) g-conh-c(＝nr 13)-nr 13r 13、 -(ch 2) n-(z) g-(ch 2) mconh-c(＝nr 13)-nr 13r 13、 -het-(ch 2) n-(z) g-(ch 2) mconh-c(＝nr 13)-nr 13r 13、 -(ch 2) n-(z) g-(chor 8) m-(z) g-conh-c(＝nr 13)-nr 13r 13、 het-(ch 2) n-(z) g-(chor 8) m-(z) g-conh-c(＝nr 13)-nr 13r 13、 -(ch 2) n-conr 7-conr 13r 13、-het-(ch 2) n-conr 7-conr 13r 13、 -(ch 2) n-(z) g-conr 7-conr 13r 13、-(ch 2) n-(z) g-conr 7-conr 13r 13、 -(ch 2) n-nr 10-(ch 2) m(chor 8) n-conr 7-conr 13r 13、 -het-(ch 2) n-nr 10-(ch 2) m(chor 8) n-conr 7-conr 13r 13、 -(ch 2) n-(chor 8) m-conr 7-conr 13r 13、 het-(ch 2) n-(chor 8) m-conr 7-conr 13r 13、 -(ch 2) n-(chor 8) m-(z) g-conr 7-conr 13r 13、 -het-(ch 2) n-(chor 8) m-(z) g-cnr 7-conr 13r 13、 -(ch 2) n-(z) g-(ch 2) mconr 7-conr 13r 13、 -het-(ch 2) n-(z) g-(ch 2) mconr 7-conr 13r 13、 -(ch 2) n-(z) g(chor 8) m-(z) g-conr 7-conr 13r 13、 -het-(ch 2) n-(z) g(chor 8) m-(z) g-conr 7-...
다중방향족 나트륨 채널 차단제본 발명은 하기 화학식으로 나타내는 다중방향족 나트륨 채널 차단제를 제공한다. (1) (상기 식에서, 변수는 앞서 정의한 바와 같다) 또한, 본 발명은 다양한 조성물, 본 나트륨 채널 차단제를 이용한 다양한 조성물, 조합 및 치료 방법도 제공한다.하기 화학식 1로 나타내는 화합물과, 이의 라세미체, 거울상 이성질체, 부분 입체 이성질체, 호변체, 동질이상체, 유사동질이상체 및 약제학상 허용되는 염. 화학식 1 [이미지]상기 식에서, X는 수소, 할로겐, 트리플루오로메틸, 저급 알킬, 비치환 또는 치환 페닐, 저급 알킬-티오, 페닐-저급 알킬-티오, 저급 알킬-설폰일, 또는 페닐-저급 알킬-설폰일이고; Y는 수소, 히드록시, 메르캅토, 저급 알콕시, 저급 알킬-티오, 할로겐, 저급 알킬, 비치환 또는 치환 단핵 아릴, 또는 -N(R2)2이고;R1은 수소 또는 저급 알킬이고;R2는 각각 독립적으로 -R7, -(CH2)m-OR8, -(CH2)m-NR7R10, -(CH2)n(CHOR8)(CHOR8)n-CH2OR8, -(CH2CH2O)m-R8, -(CH2CH2O)m-CH2CH2NR7R10, -(CH2)n-C(=O)NR7R10, -(CH2)n-Zg-R7, -(CH2)m-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -(CH2)n-CO2R7 또는 [이미지]이고; R3 및 R4는 각각 독립적으로 수소, 저급 알킬, 히드록시 저급 알킬, 페닐, (페닐)-저급 알킬, (할로페닐)-저급 알킬, {저급-(알킬)페닐}-저급 알킬, {저급 (알콕시)페닐)}-저급 알킬, (나프틸)-저급 알킬, 또는 (피리딜)-저급 알킬 또는 화학식 A 또는 B로 나타내는 그룹이고 (단, R3 및 R4 중 적어도 하나는 하기 화학식 A 또는 B로 나타내는 기이고);화학식 A: -(C(RL)2)o-x-(C(RL)2)pA1 화학식 B: -(C(RL)2)o-x-(C(RL)2)pA2A1은 적어도 하나의 R5로 치환되고 나머지 치환기는 R6인 C7-C15 방향족 카르보고리이고;A2는 적어도 하나의 R5로 치환되고 나머지 치환기는 R6인 C7-C15 방향족 이종고리이고 (상기 방향족 이종고리는 O, N 및 S로 구성되는 군으로부터 선택되는 하나 내지 네 개의 이종원자를 포함한다); RL은 각각 독립적으로 -R7, -(CH2)n-OR8, -O-(CH2)m-OR8, -(CH2)n-NR7R10, -O-(CH2)m-NR7R10, -(CH2)n(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m(CHOR8)(CHOR8)n-CH2OR8, -(CH2CH2O)m-R8, -0-(CH2CH2O)m-R8, -(CH2CH2O)m-CH2CH2NR7R10, -0-(CH2CH2O)m-CH2CH2NR7R10, -(CH2)n-C(=O)NR7R10, -O-(CH2)m-C(=O)NR7R10, -(CH2)n-(Z)g-R7, -O-(CH2)m-(Z)g-R7, -(CH2)n-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -(CH2)n-CO2R7, -O-(CH2)m-CO2R7, -OSO3H, -O-글루쿠로나이드, -O-글루코즈, [이미지] 또는 [이미지]이고; o는 각각 독립적으로 0 내지 10의 정수이고; p는 각각 독립적으로 0 내지 10의 정수이고; (단, 각 인접 사슬에서 o와 p의 합은 1 내지 10이다) x는 각각 독립적으로 O, NR10, C(=0), CHOH, C(=N-R10)-, CHNR7R10이거나, 단일 결합이고; R5는 각각 독립적으로 OH, -(CH2)m-OR8, -O-(CH2)m-OR8, -(CH2)n-NR7R10, -O-(CH2)m-NR7R10, -(CH2)n(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m(CHOR8)(CHOR8)n-CH2OR8, -(CH2CH2O)m-R8, -O-(CH2CH2O)m-R8, -(CH2CH2O)m-CH2CH2NR7R10, -O-(CH2CH2O)m-CH2CH2NR7R10, -(CH2)n-C(=O)NR7R10, -O-(CH2)m-C(=O)NR7R10, -(CH2)n-(Z)g-R7, -O-(CH2)m-(Z)g-R7, -(CH2)n-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -(CH2)n-CO2R7, -O-(CH2)m-CO2R7, -OSO3H, -O-글루쿠로나이드, -O-글루코즈, [이미지]-(CH2)n-CO2R13, -Het-(CH2)m-CO2R13, -(CH2)n-(Z)g-CO2R13, -Het-(CH2)m-(Z)g-CO2R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CO2R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-CO2R13, -(CH2)n-(CHOR8)m-CO2R13, -Het-(CH2)m-(CHOR8)m-CO2R13, -(CH2)n-(CHOR8)m(Z)g-CO2R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CO2R13, -(CH2)n-(Z)g-(CH2)m-CO2R13, -(CH2)n-(Z)g-(CH2)m-CO2R13, -(CH2)n-(Z)g(CHOR8)m-(Z)g-CO2R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CO2R13, -(CH2)n-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-CO-NH-C(=NR13)-NR13R13, -(CH2)n-(Z)g-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-(Z)g-CONH-C(=NR13)-NR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONH-C(=NR13) -NR13R13, -Het-(CH2)n-NR10-(CH2)m(CHOR8)n-CONH-C(=NR13)-NR13R13, -(CH2)n-(CHOR8)m-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-(CHOR8)m-CONH-C(=NR13)-NR13R13, -(CH2)n-(CHOR8)m-(Z)g-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CONH-C(=NR13)-NR13R13, -(CH2)n-(Z)g-(CH2)mCONH-C(=NR13)-NR13R13, -Het-(CH2)n-(Z)g-(CH2)mCONH-C(=NR13)-NR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONH-C(=NR13)-NR13R13, Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONH-C(=NR13)-NR13R13, -(CH2)n-CONR7-CONR13R13, -Het-(CH2)n-CONR7-CONR13R13, -(CH2)n-(Z)g-CONR7-CONR13R13, -(CH2)n-(Z)g-CONR7-CONR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONR7-CONR13R13, -Het-(CH2)n-NR10 -(CH2)m(CHOR8)n-CONR7-CONR13R13, -(CH2)n-(CHOR8)m-CONR7-CONR13R13, Het-(CH2)n-(CHOR8)m-CONR7-CONR13R13, -(CH2)n-(CHOR8)m-(Z)g-CONR7-CONR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CNR7-CONR13R13, -(CH2)n-(Z)g-(CH2)mCONR7-CONR13R13, -Het-(CH2)n-(Z)g-(CH2)mCONR7-CONR13R13, -(CH2)n-(Z)g(CHOR8)m-(Z)g-CONR7-CONR13R13, -Het-(CH2)n-(Z)g(CHOR8)m-(Z)g-CONR7-CONR13R13, -(CH2)n-CONR7SO2NR13R13, -Het-(CH2)m-CONR7SO2NR13R13, -(CH2)n-(Z)g-CONR7SO2NR13R13, -Het-(CH2)m-(Z)g-CONR7SO2NR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONR7SO2NR13R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-CONR7SO2NR13R13 , -(CH2)n-(CHOR8)m-CONR7SO2NR13R13, -Het-(CH2)m-(CHOR8)m-CONR7SO2NR13R13, -(CH2)n-(CHOR8)m-(Z)g-CONR7SO2NR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CONR7SO2NR13R13, -(CH2)n-(Z)g-(CH2)mCONR7SO2NR13R13, -Het-(CH2)n-(Z)g-(CH2)mCONR7SO2NR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR7SO2NR13R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR7SO2NR13R13, -(CH2)n-SO2NR13R13, -Het-(CH2)m-SO2NR13R13, -(CH2)n-(Z)g-SO2NR13R13, -Het-(CH2)m-(Z)g-SO2NR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-SO2NR13R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-SO2NR13R13 , -(CH2)n-(CHOR8)m-SO2NR13R13, -Het-(CH2)m-(CHOR8)m-SO2NR13R13, -(CH2)n-(CHOR8)m-(Z)g-SO2NR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-SO2NR13R13, -(CH2)n-(Z)g-(CH2)mSO2NR13R13, -Het-(CH2)n-(Z)g-(CH2)mSO2NR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-SO2NR13R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-SO2NR13R13, -(CH2)n-CONR13R13, -Het-(CH2)m-CONR13R13, -(CH2)n-(Z)g-CONR13R13, -Het-(CH2)m-(Z)g-CONR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONR13R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-CONR13R13, -(CH2)n-(CHOR8)m-CONR13R13, -Het-(CH2)m-(CHOR8)m-CONR13R13, -(CH2)n-(CHOR8)m-(Z)g-CONR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CONR13R13, -(CH2)n-(Z)g-(CH2)mCONR13R13, -Het-(CH2)n-(Z)g-(CH2)mCONR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-C...