Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of STAT proteinsIn one aspect, the invention relates to substituted substituted 2-hydroxy-4-(2- (phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.A compound with the structure being expressed from the next:wherein each m and n are the integer of 0-3 independently;r wherein 1be selected from a 1, a 2, – (a 1) – (a 2), – (a 2) – (a 3), – (a 3) – (a 2), – (a 3) – (a 4) ,-(a 5)-(a 1)-(a 7) ,-(a 5)-(a 2)-(a 8) ,-(a 5)-(a 3)-(a 7) and-(a 5) – (a 6) – l – (a 7); a wherein 1it is c3-c6 cycloalkyl, and be selected from a following 0-3 group and replaced: halo, hydroxyl, amino, nitro, cyano group, c1-c6 haloalkyl, c1-c6 multi-haloalkyl, c1-c6 alkoxyl, c1-c6 halogenated alkoxy, the many halogenated alkoxies of c1-c6, c1-c6 alkylthio group, c1-c6 halogenated alkylthio, the many halogenated alkylthios of c1-c6, c1-c6 alkyl amino, c1-c6 dialkyl amido, (c1-c6)-alkylidene-(c1-c6)-alkoxyl, (c1-c6)-alkylidene-(c1-c6)-halogenated alkoxy, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkoxies, (c1-c6)-alkylidene-(c1-c6)-alkylthio group, (c1-c6)-alkylidene-(c1-c6)-halogenated alkylthio, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkylthios, co 2h, (c=o) r 4, (c=o) or 4and (c=o) nhr 4, a wherein 2it is c3-c6 heterocyclylalkyl, and be selected from a following 0-3 group and replaced: halo, hydroxyl, amino, nitro, cyano group, c1-c6 haloalkyl, c1-c6 multi-haloalkyl, c1-c6 alkoxyl, c1-c6 halogenated alkoxy, the many halogenated alkoxies of c1-c6, c1-c6 alkylthio group, c1-c6 halogenated alkylthio, the many halogenated alkylthios of c1-c6, c1-c6 alkyl amino, c1-c6 dialkyl amido, (c1-c6)-alkylidene-(c1-c6)-alkoxyl, (c1-c6)-alkylidene-(c1-c6)-halogenated alkoxy, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkoxies, (c1-c6)-alkylidene-(c1-c6)-alkylthio group, (c1-c6)-alkylidene-(c1-c6)-halogenated alkylthio, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkylthios, co 2h, (c=o) r 5, (c=o) or 5and (c=o) nhr 5, a wherein 3it is aryl, and be selected from a following 0-3 group and replaced: halo, hydroxyl, amino, nitro, cyano group, c1-c6 haloalkyl, c1-c6 multi-haloalkyl, c1-c6 alkoxyl, c1-c6 halogenated alkoxy, the many halogenated alkoxies of c1-c6, c1-c6 alkylthio group, c1-c6 halogenated alkylthio, the many halogenated alkylthios of c1-c6, c1-c6 alkyl amino, c1-c6 dialkyl amido, (c1-c6)-alkylidene-(c1-c6)-alkoxyl, (c1-c6)-alkylidene-(c1-c6)-halogenated alkoxy, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkoxies, (c1-c6)-alkylidene-(c1-c6)-alkylthio group, (c1-c6)-alkylidene-(c1-c6)-halogenated alkylthio, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkylthios, co 2h, (c=o) r 6, (c=o) or 6and (c=o) nhr 6, a wherein 4it is aryl, and be selected from a following 1-3 group and replaced: halo, hydroxyl, amino, nitro, cyano group, c1-c6 haloalkyl, c1-c6 multi-haloalkyl, c1-c6 alkoxyl, c1-c6 halogenated alkoxy, the many halogenated alkoxies of c1-c6, c1-c6 alkylthio group, c1-c6 halogenated alkylthio, the many halogenated alkylthios of c1-c6, c1-c6 alkyl amino, c1-c6 dialkyl amido, (c1-c6)-alkylidene-(c1-c6)-alkoxyl, (c1-c6)-alkylidene-(c1-c6)-halogenated alkoxy, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkoxies, (c1-c6)-alkylidene-(c1-c6)-alkylthio group, (c1-c6)-alkylidene-(c1-c6)-halogenated alkylthio, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkylthios, co 2h, (c=o) r 7, (c=o) or 7and (c=o) nhr 7, a wherein 5be selected from c3-c6 cycloalkyl, c3-c6 heterocyclylalkyl and aryl, and be selected from a following 0-3 group and replaced: halo, hydroxyl, amino, nitro, cyano group, c1-c6 haloalkyl, c1-c6 multi-haloalkyl, c1-c6 alkoxyl, c1-c6 halogenated alkoxy, the many halogenated alkoxies of c1-c6, c1-c6 alkylthio group, c1-c6 halogenated alkylthio, the many halogenated alkylthios of c1-c6, c1-c6 alkyl amino, c1-c6 dialkyl amido, (c1-c6)-alkylidene-(c1-c6)-alkoxyl, (c1-c6)-alkylidene-(c1-c6)-halogenated alkoxy, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkoxies, (c1-c6)-alkylidene-(c1-c6)-alkylthio group, (c1-c6)-alkylidene-(c1-c6)-halogenated alkylthio, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkylthios, co 2h, (c=o) r 8, (c=o) or 8and (c=o) nhr 8, a wherein 6be selected from c3-c6 cycloalkyl, c3-c6 heterocyclylalkyl and aryl, and be selected from a following 0-3 group and replaced: halo, hydroxyl, amino, nitro, cyano group, c1-c6 haloalkyl, c1-c6 multi-haloalkyl, c1-c6 alkoxyl, c1-c6 halogenated alkoxy, the many halogenated alkoxies of c1-c6, c1-c6 alkylthio group, c1-c6 halogenated alkylthio, the many halogenated alkylthios of c1-c6, c1-c6 alkyl amino, c1-c6 dialkyl amido, (c1-c6)-alkylidene-(c1-c6)-alkoxyl, (c1-c6)-alkylidene-(c1-c6)-halogenated alkoxy, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkoxies, (c1-c6)-alkylidene-(c1-c6)-alkylthio group, (c1-c6)-alkylidene-(c1-c6)-halogenated alkylthio, (c1-c6)-alkylidene-(c1-c6)-many halogenated alkylthios, co 2h, (c=o) r 9, (c=o) or 9and (c=o) nhr 9, a wherein 7be selected from c3-c6 cycloalkyl, c3-c6 heterocyclylalkyl and aryl, and be selected from a following 0-3 group and replaced: halo, hydroxyl, amino, nitro, cyano group, c1-c6 haloalkyl, c1-c6 multi-haloalkyl, c1-c6 alkoxyl, c1-c6 halogenated alkoxy, the many halogena...
STAT 단백질의 저해제로서의 치환된 2-히드록시-4-(2-(페닐설폰아미도)아세트아미도)벤조산 유사체한 양상에서, 본 발명은 STAT 단백질 활성의 저해제로서 유용한 치환된 치환된 2-히드록시-4-(2-(페닐설폰아미도)아세트아미도)벤조산 유사체, 그의 유도체, 및 관련 화합물; 상기 화합물을 만들기 위한 합성 방법; 상기 화합물을 포함하는 약제학적 조성물; 그리고 상기 화합물 및 조성물을 이용하여 STAT 단백질 활성 기능이상과 연관된 제어되지 않는 세포 증식의 장애를 치료하는 방법에 관한 것이다. 본 요약은 특정 기술에서 검색의 목적을 위한 탐색 수단으로서 의도되며 본 발명을 제한하는 것으로 의도되지 않는다.다음 식으로 표현되는 구조를 가지는 화합물:[이미지],여기서 각각의 m 및 n은 독립적으로 0-3 중의 정수이고;여기서 R1은 A1, A2, -(A1)-(A2), -(A2)-(A3), -(A3)-(A2), -(A3)-(A4), -(A5)-(A1)-(A7), -(A5)-(A2)-(A8), -(A5)-(A3)-(A7), 및 -(A5)-(A6)-L-(A7) 중에서 선택되고;여기서 A1은 C3-C6 시클로알킬이며, 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)R4, (C=O)OR4, 및 (C=O)NHR4 중에서 선택된 0-3개의 기로 치환되고;여기서 A2는 C3-C6 헤테로시클로알킬이며, 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)R5, (C=O)OR5, 및 (C=O)NHR5 중에서 선택된 0-3개의 기로 치환되고;여기서 A3은 아릴이며, 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)R6, (C=O)OR6, 및 (C=O)NHR6 중에서 선택된 0-3개의 기로 치환되고;여기서 A4는 아릴이며, 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)R7, (C=O)OR7, 및 (C=O)NHR7 중에서 선택된 1-3개의 기로 치환되고;여기서 A5는 C3-C6 시클로알킬, C3-C6 헤테로시클로알킬, 및 아릴 중에서 선택되고, 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)R8, (C=O)OR8, 및 (C=O)NHR8 중에서 선택된 0-3개의 기로 치환되고;여기서 A6은 C3-C6 시클로알킬, C3-C6 헤테로시클로알킬, 및 아릴 중에서 선택되고, 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)R9, (C=O)OR9, 및 (C=O)NHR9 중에서 선택된 0-3개의 기로 치환되고;여기서 A7은 C3-C6 시클로알킬, C3-C6 헤테로시클로알킬, 및 아릴 중에서 선택되고, 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)R10, (C=O)OR10, 및 (C=O)NHR10 중에서 선택된 0-3개의 기로 치환되고;여기서 A8은 C3-C6 시클로알킬, C3-C6 헤테로시클로알킬, 및 아릴 중에서 선택되고, 할로, 히드록실, 아미노, 니트로, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)R11, (C=O)OR11, 및 (C=O)NHR11 중에서 선택된 0-3개의 기로 치환되고;여기서 L은 -(C=O)- 및 -SO2- 중에서 선택되고;여기서 R2는 C1-C6 알킬, C2-C6 알케닐, C2-C6 알키닐, C1-C6 할로알킬, C2-C6 할로알케닐, C2-C6 할로알키닐, C1-C6 폴리할로알킬, C2-C6 폴리할로알케닐, C2-C6 폴리할로알키닐 중에서 선택되거나; 또는여기서 R2는 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬티오, C1-C6 할로알키티오, C1-C6 폴리할로알킬티오, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, (C1-C6)-알크-(C1-C6)-폴리할로알콕시, (C1-C6)-알크-(C1-C6)-알킬티오, (C1-C6)-알크-(C1-C6)-할로알키티오, (C1-C6)-알크-(C1-C6)-폴리할로알킬티오, CO2H, (C=O)OR11, 및 (C=O)NHR11 중에서 독립적으로 선택된 0-5개의 기로 치환된 아릴이며;여기서 R3은 할로, 히드록실, 아미노, 니트로, 시아노, C1-C6 알킬, C1-C6 할로알킬, C1-C6 폴리할로알킬, C1-C6 알콕시, C1-C6 할로알콕시, C1-C6 폴리할로알콕시, C1-C6 알킬아미노, C1-C6 디알킬아미노, (C1-C6)-알크-(C1-C6)-알콕시, (C1-C6)-알크-(C1-C6)-할로알콕시, 및 (C1-C6)-알크-(C1-C6)-폴리할로알콕시 중에서 독립적으로 선택된 0-5개의 기로 치환된 아릴이며; 그리고여기서 각각의 R4, R5, R6, R7, R8, R9, R10, 및 R11은 독립적으로 수소, C1-C6 알킬, C1-C6 할로알킬, 및 C1-C6 폴리할로알킬 중에서 선택됨;또는 그의 약제학적으로 허용되는 염, 수화물, 용매화물, 또는 다형체.