Oxazine derivatives and their use in the treatment of neurological disordersThe invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in pharmaceutically acceptable salt form, to their preparation, to their medical use and to medicaments comprising them.Compound and the pharmacologically acceptable salt thereof of formula (i)wherein defined r 1, r 2, r 3, r 4, r 5and r 6thereby, obtain being selected from following compound: the chloro-3-methoxymethyl-pyridine of 5--2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;the chloro-5-cyano group-pyridine of 3--2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-tri--deuterium generation-methoxyl group-pyrazine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-third-2-alkynyloxy group-pyrazine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;the chloro-1h-pyrrolo-of 3-[2,3-b] pyridine-6-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-difluoromethyl-pyrazine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;5-methoxyl group-3-methyl-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;5-difluoromethyl-3-methyl-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;fluoro-3-tri-deuteriums of 5-are for methoxymethyl-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;5-tri-deuteriums for methoxyl group-3-tri-deuteriums for methoxymethyl-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-cyano-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-difluoromethyl-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;5-tri-deuteriums are for methoxyl group-3-methyl-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;5-cyano group-3-methyl-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazine-3-yl)-4, the fluoro-phenyl of 5-bis-]-acid amides;chloro-5-tri-deuteriums of 3-are for methoxyl group-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazine-3-yl)-4, the fluoro-phenyl of 5-bis-]-acid amides;chloro-3-tri-deuteriums of 4,6-, bis-deuterium generation-5-are for methyl-pyridine-2-formic acid [3-(5-amino-3-difluoromethyl-3,6-dihydro-2h-[1,4] oxazine-3-yl)-4, the fluoro-phenyl of 5-bis-]-acid amides;the chloro-5-cyano group-pyridine of 3--2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-chloro-5-methoxyl-pyridine-2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;the chloro-5-difluoro-methoxy-pyridine of 3--2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;the chloro-3-methyl-pyridine of 5--2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;the fluoro-pyridine of the chloro-3-of 5--2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;the chloro-5-tri-deuterium generation-methoxyl groups of 3--pyridine-2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;2,5-dimethyl ,-oxazoles-4-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;5-difluoro-methoxy-3-methyl-pyridine-2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-third-2-alkynyloxy group-pyrazine-2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-cyano-pyridine-2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;5-difluoromethyl-3-methyl-pyridine-2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-difluoromethyl-pyrazine-2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;3-amino-5-difluoromethyl-pyridine-2-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2h-[1,4] oxazines-3-yl)-fluoro-phenyl of 4-]-acid amides;4-difluoromethyl-6-methoxyl group-pyridazine-3-formic acid [3-(5-amino-3,6-dimethyl-6-trifluoromethyl...
옥사진 유도체 및 신경계 장애의 치료에서의 그의 용도본 발명은 유리 형태 또는 제약상 허용되는 염 형태의 하기 화학식 I의 신규 헤테로시클릭 화합물, 그의 제조법, 그의 의학적 용도 및 그를 포함하는 의약에 관한 것이다. <화학식 I> 상기 식에서, 모든 가변기는 명세서에 정의된 바와 같다.하기 화학식 I의 화합물 및 그의 제약상 허용되는 염.<화학식 I>[이미지]상기 식에서, R1, R2, R3, R4, R5 및 R6은5-클로로-3-메톡시메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4] 옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-시아노-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-트리스-듀테로-메톡시-피라진-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-프로프-2-이닐옥시-피라진-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-1H-피롤로[2,3-b]피리딘-6-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-디플루오로메틸-피라진-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-메톡시-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-디플루오로메틸-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-플루오로-3-트리듀테로메톡시메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-트리듀테로메톡시-3-트리듀테로메톡시메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-시아노-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-디플루오로메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-트리듀테로메톡시-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-시아노-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4,5-디플루오로-페닐]-아미드;3-클로로-5-트리듀테로메톡시-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4,5-디플루오로-페닐]-아미드;4,6-디듀테로-5-클로로-3-트리듀테로메틸-피리딘-2-카르복실산 [3-(5-아미노-3-디플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4,5-디플루오로-페닐]-아미드;3-클로로-5-시아노-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-메톡시-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-디플루오로메톡시-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-클로로-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-클로로-3-플루오로-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-트리듀테로-메톡시-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;2,5-디메틸-옥사졸-4-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-디플루오로메톡시-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-프로프-2-이닐옥시-피라진-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-시아노-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-디플루오로메틸-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-디플루오로메틸-피라진-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-디플루오로메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;4-디플루오로메틸-6-메톡시-피리다진-3-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-시아노-3-트리듀테로메톡시메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-디플루오르메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-트리듀테로메톡시-디듀테로메틸-1H-피롤로[2,3-b]피리딘-6-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-트리플루오로메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-플루오로-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로-메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-트리듀테로메톡시-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-시아노-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-6,6-비스-플루오로메틸-3-메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-디플루오로메톡시-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-6,6-비스-플루오로메틸-3-메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-클로로-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-6,6-비스-플루오로메틸-3-메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-시아노-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6,6-트리스-플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-디플루오로메틸-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-6,6-비스-플루오로메틸-3-메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-디플루오로메틸-피라진-2-카르복실산 [3-(5-아미노-6,6-비스-플루오로메틸-3-메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-디플루오로메틸-피리딘-2-카르복실산 [3-(5-아미노-6,6-비스-플루오로메틸-3-메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-시아노-피리딘-2-카르복실산 [3-(5-아미노-6,6-비스-플루오로메틸-3-메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;5-디플루오로메틸-3-메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6,6-트리스-플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-디플루오로메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6,6-트리스-플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-트리플루오로메틸-피리딘-2-카르복실산 [3-(5-아미노-3,6,6-트리스-플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3,5-디클로로-피리딘-2-카르복실산 [3-(5-아미노-3,6,6-트리스-플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-아미노-5-시아노-피리딘-2-카르복실산 [3-(5-아미노-3,6,6-트리스-플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;3-클로로-5-시아노-피리딘-2-카르복실산 [3-(5-아미노-3,6,6-트리스-플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-아미드;N-[3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-6-메톡시-2-메틸-니코틴아미드;N-[3-(5-아미노-3,6-디메틸-6-트리플루오로메틸-3,6-디히드로-2H-[1,4]옥사진-3-일)-4-플루오로-페닐]-6-트리듀테로메톡시-2-메틸-니코틴아미드;2-아미노-N-[3-(5-아미노-3,6...