Combinations and use of selected pharmaceutically active compoundsThe present invention relates to new combinations and new uses of certain selected tricyclic imidazo [1,2-a]pyridine compounds in the prevention or treatment of medicament caused gastrointestinal diseases. A pharmaceutical composition comprising a first active ingredient, which is a tricyclic imidazo[1,2-a]pyridine compound selected from the group consisting of the tricyclic imidazo[1,2-a]pyridine compounds which are specifically disclosed and/or individualized and/or claimed in the patent applications WO 9842707, WO 0017200, WO 0026217, WO 0063211, WO 0172756, WO 0172755, WO 0172757, WO 0234749, WO 03014120, WO 03014123, WO 03016310 and WO 03091253, and which are not substituted by a hydroxy-1-4C-alkyl radical bonded on the imidazo ring; or is a compound selected from the group consisting of  (7S,8R,9R)-2,3-dimethyl-7,8-dihydroxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-7,8-isopropylidenedioxy-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, 7,8-dihydroxy-9-phenyl-2,3-dimethyl-7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridine, (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8S,9S)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8S,9S)-2,3-dimethyl-8-hydroxy-7-methoxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-2,3-dimethyl-7-ethoxy-8-hydroxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-2,3-dimethyl-7-ethoxy-8-hydroxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8S,9S)-2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8S,9S)-2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-2,3-dimethyl-8-hydroxy-9-phenyl-7-(2-propoxy)-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-2,3-dimethyl-7,8-dimethoxy-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methylthioethyloxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]-naphthyridine, (7S,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methylthioethyloxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]-naphthyridine, (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methylsulphinylethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo-[1,2-h][1,7]naphthyridine, (7S,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methylsulphinylethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo-[1,2-h][1,7]naphthyridine, (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-(ethylthio)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-2,3-dimethyl-8-hydroxy-7-(ethylthio)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2,2,2-trifluoroethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo-[1,2-h][1,7]naphthyridine, (7S,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2,2,2-trifluoroethoxy)-9-phenyl-7,8,9,10-tetrahydroimidazo-[1,2-h][1,7]naphthyridine, (7S,8R,9R)-8-acetoxy-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-8-acetoxy-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-8-acetoxy-7-methoxy-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-8-acetoxy-7-ethoxy-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-8-propionyloxy-7,8,9,10-tetrahydroimidazo[1,2-h]-[1,7]naphthyridine, (7R,8R,9R)-8-benzoyloxy-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-8-benzoyloxy-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-8-methoxycarbonyloxy-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-8-methoxycarbonyloxy-7-(2-methoxyethoxy)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-8-benzoyloxy-7-methoxy-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-8-benzoyloxy-7-methoxy-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-7-(2-methoxyethoxy)-2,3-dimethyl-8-(4-nitrobenzoyloxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-7-(2-methoxyethoxy)-2,3-dimethyl-8-(4-nitrobenzoyloxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-7-(2-methoxyethoxy)-2,3-dimethyl-8-(3-nitrobenzoyloxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7R,8R,9R)-7-(2-methoxyethoxy)-2,3-dimethyl-8-(3-nitrobenzoyloxy)-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine, (7S,8R,9R)-7-methoxy-2,3-dimethyl-8-(3-nitrobe...
이미다조피리딘 함유 조합물, 및 위장관 염증성 질환 치료시의 이의 용도본 발명은 약제 원인성 위장관 질환의 예방 또는 치료에 사용되는 특정한 트리시클릭 이미다조[1,2-a]피리딘 화합물의 신규한 조합물 및 신규한 용도에 관한 것이다. 제1 활성 성분 및 제2 활성 성분을 포함하는 약학 조성물로서, 제1 활성 성분은 특허 출원 WO 9842707, WO 0017200, WO 0026217, WO 0063211, WO 0172756, WO 0172755, WO 0172757, WO 0234749, WO 03014120, WO 03014123, WO 03016310 및 WO 03091253에서 구체적으로 개시 및/또는 특기 및/또는 청구되고, 이미다조 고리 상에 결합된 히드록시-1-4C-알킬 라디칼로 치환되지 않은 트리시클릭 이미다조[1,2-a]피리딘 화합물; 및 화합물 (7S,8R,9R)-2,3-디메틸-7,8-디히드록시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-7,8-이소프로필리덴디옥시-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, 7,8-디히드록시-9-페닐-2,3-디메틸-7H-8,9-디히드로피라노[2,3-c]이미다조[1,2-a]피리딘, (7R,8R,9R)-2,3-디메틸-8-히드록시-7-메톡시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8S,9S)-2,3-디메틸-8-히드록시-7-메톡시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-2,3-디메틸-8-히드록시-7-메톡시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8S,9S)-2,3-디메틸-8-히드록시-7-메톡시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-2,3-디메틸-7-에톡시-8-히드록시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-2,3-디메틸-7-에톡시-8-히드록시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-2,3-디메틸-8-히드록시-7-(2-메톡시에톡시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8S,9S)-2,3-디메틸-8-히드록시-7-(2-메톡시에톡시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-2,3-디메틸-8-히드록시-7-(2-메톡시에톡시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8S,9S)-2,3-디메틸-8-히드록시-7-(2-메톡시에톡시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-2,3-디메틸-8-히드록시-9-페닐-7-(2-프로폭시)-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-2,3-디메틸-7,8-디메톡시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-2,3-디메틸-8-히드록시-7-(2-메틸티오에틸옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-2,3-디메틸-8-히드록시-7-(2-메틸티오에틸옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-2,3-디메틸-8-히드록시-7-(2-메틸설피닐에톡시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-2,3-디메틸-8-히드록시-7-(2-메틸설피닐에톡시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-2,3-디메틸-8-히드록시-7-(에틸티오)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-2,3-디메틸-8-히드록시-7-(에틸티오)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-2,3-디메틸-8-히드록시-7-(2,2,2-트리플루오로에톡시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-2,3-디메틸-8-히드록시-7-(2,2,2-트리플루오로에톡시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-8-아세톡시-7-(2-메톡시에톡시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-아세톡시-7-(2-메톡시에톡시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-아세톡시-7-메톡시-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-아세톡시-7-에톡시-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-9-페닐-8-프로피오닐옥시-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-벤조일옥시-7-(2-메톡시에톡시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-8-벤조일옥시-7-(2-메톡시에톡시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-메톡시카르보닐옥시-7-(2-메톡시에톡시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-8-메톡시카르보닐옥시-7-(2-메톡시에톡시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-벤조일옥시-7-메톡시-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-8-벤조일옥시-7-메톡시-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-8-(4-니트로벤조일옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-8-(4-니트로벤조일옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-8-(3-니트로벤조일옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-8-(3-니트로벤조일옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-7-메톡시-2,3-디메틸-8-(3-니트로벤조일옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-7-메톡시-2,3-디메틸-8-(3-니트로벤조일옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-8-(4-메톡시벤조일옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-8-(4-메톡시벤조일옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-8-(N,N-디메틸아미노메틸카르보닐옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-7-(2-메톡시에톡시)-2,3-디메틸-8-(N,N-디메틸아미노메틸카르보닐옥시)-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-7-(2-메톡시에톡시)-8-(N,N-디에틸아미노카르보닐옥시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-7-(2-메톡시에톡시)-8-(N,N-디에틸아미노카르보닐옥시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-에틸아미노카르보닐옥시-7-(2-메톡시에톡시)-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-벤조일옥시-2,3-디메틸-7-(2-메톡시에톡시)-9-페닐-7H-8,9-디히드로피라노[2,3-c]이미다조[1,2-a]피리딘, (7S,8R,9R)-8-벤조일옥시-2,3-디메틸-7-(2-메톡시에톡시)-9-페닐-7H-8,9-디히드로피라노[2,3-c]이미다조[1,2-a]피리딘, (7R,8R,9R)-8-[4-(메톡시카르보닐)-벤조일옥시]-2,3-디메틸-7-(2-메톡시에톡시)-9-페닐-7H-8,9-디히드로피라노[2,3-c]이미다조[1,2-a]피리딘, (7S,8R,9R)-8-[4-(메톡시카르보닐)-벤조일옥시]-2,3-디메틸-7-(2-메톡시에톡시)-9-페닐-7H-8,9-디히드로피라노[2,3-c]이미다조[1,2-a]피리딘, (7S,8R,9R)-2,3-디메틸-7-메톡시-8-메톡시아세틸옥시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-8-(N,N-디에틸아미노카르보닐옥시)-2,3-디메틸-7-메톡시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-8-(N,N-디에틸아미노카르보닐옥시)-2,3-디메틸-7-메톡시-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-7-메톡시-8-메톡시카르보닐옥시-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7S,8R,9R)-7-메톡시-8-메톡시카르보닐옥시-2,3-디메틸-9-페닐-7,8,9,10-테트라히드로이미다조[1,2-h][1,7]나프티리딘, (7R,8R,9R)-2,3-디메틸-8-포르밀옥시-7-메톡시-9-페닐-...