Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their useArylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use. The invention relates to compounds of the formula I in which the radicals R and R', A, D, E, G, L, p and R1 to R1O have the stated definitions, and also to their physiologically tolerated salts. The compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.The compound of formula I with and the compatible salt of physiologyWhereinR, R ' are H, (C independently of one another 1-C 6)-alkyl, wherein (C 1-C 6)-alkyl can be by halogen, O-R14, S (O) m-R12 or NR13R15 replace; Perhaps R and R ' form the ring with 3 to 8 carbon atoms together, and one of them carbon atom can be by O, S (O) m, NR13 or NR15 substitute; M is 0,1,2;N is 0,1,2,3,4;P is 1,2,3,4,5;Q is 1,2,3,4;R is 2,3,4,5,6;V is 0,1,2,3,4;A, D, E, G, L are C or N independently of one another, wherein when it is defined as N, do not have corresponding R1, R2, R3, R4, R5 substituting group;R1, R2, R3, R4, R5 are H, F, Cl, Br, I, CN, N independently of one another 3, NC, NO 2, CF 3, (C 1-C 8)-alkyl, (C 3-C 8)-cycloalkyl, (CH 2) n-[(C 3-C 8)-cycloalkenyl group], (CH 2) q-[(C 3-C 8)-cycloalkyl], (CH 2) n-[(C 7-C 12)-bicyclic alkyl], (CH 2) n-[(C 7-C 12)-bicycloenyl], (CH 2) n-[(C 7-C 12)-tricyclic alkyl], diamantane-1-base, diamantane-2-base, (CH 2) n-aryl, (CH 2) n-heteroaryl, OCF 3, O-R11, NR13R15, NH-CN, S (O) m-R12, SO 2-NH 2, SO 2-N=CH-N (CH 3) 2, SO 2-NH-CO-R12, SO 2-NH-CO-NHR12, SO 2-NH-CO-R16, SO 2-NH-[(C 1-C 8)-alkyl], SO 2-NH-[(C 3-C 8)-cycloalkyl], SO 2-NH-(CH 2) r-OH, SO 2-NH-(CH 2) n-aryl, SO 2-NH-(CH 2) n-heteroaryl, SO 2-N[(C 1-C 8)-alkyl] 2, SO 2-R16, SF 5, CO-O[(C 1-C 8)-alkyl], CO-O[(C 3-C 8)-cycloalkyl], CO-O-(CH 2) r-NH 2, CO-O-(CH 2) n-aryl, CO-O-(CH 2) n-heteroaryl, CO-NH 2, CO-NH-CN, CO-NH-[(C 1-C 8)-alkyl], CO-NH-(CH 2) r-OH, CO-N[(C 1-C 8)-alkyl] 2, CO-NH-[(C 3-C 8)-cycloalkyl], CO-N[(C 3-C 8)-cycloalkyl] 2, C (=NH)-O-[(C 1-C 6-alkyl)], C (=NH)-NH 2, C (=NH)-NHOH, C (=NH)-[NHO-(C 1-C 6)-alkyl], C (=NH)-NR12R13, C (=NH)-R16, C (=NR13)-NR12R13, CO-NH-SO 2-R16, CO-NH-SO 2-NHR12, CO-R16, COOH, CO-(C 1-C 8)-alkyl, CO-(C 3-C 8)-cycloalkyl, CO-(CH 2) n-[(C 7-C 12)-bicyclic alkyl], CO-(CH 2) n-[(C 7-C 12)-tricyclic alkyl], CO-aryl, CO-heteroaryl, CH (OH)-aryl, CH (OH)-heteroaryl, CH[O-(C 1-C 6)-alkyl]-aryl, CH[O-(C 1-C 6)-alkyl]-heteroaryl, CHF-aryl, CHF-heteroaryl, CF 2-aryl, CF 2-heteroaryl, CHO, CH 2-OH, CH 2-CN, CH 2-O-R12, CH 2-O-(CH 2) n-CO-O[(C 1-C 8)-alkyl], CH 2-O-(CH 2) n-CO-NH 2, CH 2-O-(CH 2) q-COOH, wherein said alkyl, cycloalkyl, cycloalkenyl group, bicyclic alkyl, bicycloenyl and tricyclic alkyl can be replaced by fluorine atom and aryl wherein or heteroaryl can be by halogen, CN, (C 1-C 6)-alkyl, (C 3-C 6)-cycloalkyl, O-(C 1-C 6)-alkyl, S (O) m-(C 1-C 6)-alkyl, SO 2-NH 2, COOH, CONH 2, CO-O (C 1-C 6)-alkyl, CO-(C 1-C 6)-alkyl replaces and alkyl wherein can be replaced by fluorine atom; R6, R7, R8, R9, R10 are R11, NR17-bicyclic heterocycles, NR17-aryl, NR17-heteroaryl independently of one another, aryl wherein or heteroaryl can be carbocyclic fused with 5-or 6-person's aromatics or non-aromatics, one or more CH or CH in described aromatics or the non-aromatic carbocyclic 2Group can be substituted by Sauerstoffatom and wherein this 5-or 6-person's aromatics or non-aromatic carbocyclic can by F ,=O or-(C 1-C 6)-alkyl replaces, and described bicyclic heterocycles can comprise 9 to 12 ring memberses and 5 CH or CH at the most 2Group can be independently of one another by N, NR20, O, S (O) mOr C=O substitutes, and aryl wherein or heteroaryl or bicyclic heterocycles can not be substituted or by following group list-or polysubstituted: R11、F、Cl、Br、I、CN、N 3、NC、NO 2、CF 3、(CH 2) n-O-R11、 (CH 2) n-O-(CH 2) r-OH、(CH 2) n-O-CH(CH 2OH) 2、 (CH 2) n-O-(CH 2) n-CO-O-(CH 2) r-NH 2、 (CH 2) n-O-(CH 2) n-CO-NH-(CH 2) r-OH、(CH 2) n-O-sugar, (CH2) n-O-saccharic acid, (CH2) n-O-glucoside, (CH2) n-O-galactoside, (CH2) n-O-glucuronide, O-R13, OCF3、(CH 2) n-O-(CH 2) r-NH 2、(CH 2) n-NH-R11、 (CH 2) n-N[(CH 2) q-CO-O(C 1-C 6)-alkyl]2、(CH 2) n-N[(CH 2) q-COOH] 2、 (CH 2) n-N[(CH 2) q-CONH 2] 2、(CH 2) n-NH-R13、(CH 2) n-N(R13) 2、 (CH 2) n-NH-CN、(CH 2) n-NH-SO 2-R16、(CH 2) n-NH-(CH 2)n-SO 2-R12、 (CH 2) n-NR12-CO-R16、(CH 2) n-NR12-CO-NR12R13、 (CH 2) n-NR12-CO-N(R12) 2、(CH 2) n-NR12-CO-NHR11、 (CH 2) n-NH-C(＝NH)-NH 2、(CH 2) n-NH-C(＝NH)-R16、 (CH 2) n-NH-C(＝NH)-NHR12、(CH 2) n-NR12-C(＝NR13)-NHR12、 (CH 2) n-NR12-C(＝NR12)-NR12R13、 (CH 2) n-NH-(CH 2) n-CO-O-(CH 2) r-NH 2、 (CH 2) n-NH-(CH 2) n-CO-NH-[(C 1-C 8)-alkyl], (CH2) n-NH-(CH 2) n-CO-NH-(CH 2) r-OH、 (CH 2) n-NH-(CH 2) n-CO-N[(C 1-C 8)-alkyl]2、 (CH 2) n-NH-(CH 2) n-CO-NH-[(C 3-C 8)-cycloalkyl], (CH2) n-NH-(CH 2) n-CO-N[(C 3-C 8)-cycloalkyl]2、 (CH 2) n-NH-C(CH 3) 2-CO-O(C 1-C 8)-alkyl, (CH2) n-NH-C(CH 3) 2-CO-O(C 3-C 8)-cycloalkyl, (CH2) n-NH-C(CH 3) 2-CO-O-(CH 2)r-NH 2、 (CH 2) n-NH-C(CH 3) 2-CO-O-(CH 2) n-aryl, (CH2) n-NH-C(CH 3) 2-CO-O-(CH 2) n-heteroaryl, (CH2) n-NH-C(CH 3) 2-CO-NH 2、 (CH 2) n-NH-C(CH 3) 2-CO-NH-[(C 1-C 8)-alkyl], (CH2) n-NH-C(CH 3) 2-CO-NH-(CH 2) r-OH、 (CH 2) n-NH-C(CH 3) 2-CO-N[(C 1-C 8)-alkyl]2、 (CH 2) n-NH-(CH 3) 2-Co-NH-[(C 3-C 8)-cycloalkyl], (CH2) n-NH-C(CH 3) 2-CO-N[(C 3-C 8)-cycloalkyl]2、 (CH 2) n-NH-C(CH 3) 2-COOH、S(O) m-R12、SO 2-R16、 SO 2-N＝CH-N(CH 3) 2、 SO 2-NH-CO-R12、SO 2-NHR12、 SO 2-NH-(CH 2) r-OH、SO 2-N[(C 1-C 8)-alkyl]2、SO 2-NH-(CH 2...
아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도본 발명은 본 발명은 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도에 관한 것이다. 본 발명은 화학식 I의 화합물 및 이의 생리학적으로 허용되는 이의 염에 관한 것이다. 화학식 I  위의 화학식 I에서, 라디칼 R 및 R', A, D, E, G, L, p 및 R1 내지 R10은 명세서에서 정의한 바와 같다. 상기 화합물은, 예를 들면, 항비만제로서 적합하며, 심혈관대사 증후군 치료에 적합하다. 화학식 I의 화합물 또는 생리학적으로 혼화성인 이의 염. 화학식 I [이미지] 위의 화학식 I에서, R 및 R'는 각각 독립적으로 H, (C1-C6)-알킬(여기서, (C1-C6)-알킬은 할로겐으로 치환될 수 있다), O-R14, S(O)m-R12 또는 NR13R15이거나, R과 R'와 함께 탄소수 3 내지 8의 환을 형성하고, 여기서, 하나의 탄소원자는 O, S(O)m, NR13 또는 NR15로 대체될 수 있고, m은 0, 1 또는 2이며, n은 0, 1, 2, 3 또는 4이고, p는 1, 2, 3, 4 또는 5이며, q는 1, 2, 3 또는 4이고, r은 2, 3, 4, 5 또는 6이며, v는 0, 1, 2, 3 또는 4이고, A, D, E, G 및 L은 각각 독립적으로 C 또는 N이고, 여기서 이들이 N으로 정의되는 경우, R1, R2, R3, R4 및 R5 치환체에 상응하는 것이 존재하지 않으며, R1, R2, R3, R4 및 R5는 각각 독립적으로 H, F, Cl, Br, I, CN, N3, NC, NO2, CF3, (C1-C8)-알킬, (C3-C8)-사이클로알킬, (CH2)n-[(C3-C8)-사이클로알케닐], (CH2)q-[(C3-C8)-사이클로알킬], (CH2)n-[(C7-C12)-바이사이클로알킬], (CH2)n-[(C7-C12)-바이사이클로알케닐], (CH2)n-[(C7-C12)-트리사이클로알킬], 아다만탄-1-일, 아다만탄-2-일, (CH2)n-아릴, (CH2)n-헤테로아릴, OCF3, O-R11, NR13R15, NH-CN, S(O)m-R12, SO2-NH2, SO2-N=CH-N(CH3)2, SO2-NH-CO-R12, SO2-NH-CO-NHR12, SO2-NH-CO-R16, SO2-NH-[(C1-C8)-알킬], SO2-NH-[(C3-C8)-사이클로알킬], SO2-NH-(CH2)r-OH, SO2-NH-(CH2)n-아릴, SO2-NH-(CH2)n-헤테로아릴, SO2-N[(C1-C8)-알킬]2, SO2-R16, SF5, CO-O[(C1-C8)-알킬], CO-O[(C3-C8)-사이클로알킬], CO-O-(CH2)r-NH2, CO-O-(CH2)n-아릴, CO-O-(CH2)n-헤테로아릴, CO-NH2, CO-NH-CN, CO-NH-[(C1-C8)-알킬], CO-NH-(CH2)r-OH, CO-N[(C1-C8)-알킬]2, CO-NH-[(C3-C8)-사이클로알킬], CO-N[(C3-C8)-사이클로알킬]2, C(=NH)-O-[(C1-C6-알킬)], C(=NH)-NH2, C(=NH)-NHOH, C(=NH)-[NHO-(C1-C6)-알킬], C(=NH)-NR12R13, C(=NH)-R16, C(=NR13)-NR12R13, CO-NH-SO2-R16, CO-NH-SO2-NHR12, CO-R16, COOH, CO-(C1-C8)-알킬, CO-(C3-C8)-사이클로알킬, CO-(CH2)n-[(C7-C12)-바이사이클로알킬], CO-(CH2)n-[(C7-C12)-트리사이클로알킬], CO-아릴, CO-헤테로아릴, CH(OH)-아릴, CH(OH)-헤테로아릴, CH[O-(C1-C6)-알킬]-아릴, CH[O-(C1-C6)-알킬]-헤테로아릴, CHF-아릴, CHF-헤테로아릴, CF2-아릴, CF2-헤테로아릴, CHO, CH2-OH, CH2-CN, CH2-O-R12, CH2-O-(CH2)n-CO-O[(C1-C8)-알킬], CH2-O-(CH2)n-CO-NH2, CH2-O-(CH2)q-COOH이며, 여기서, 당해 알킬, 사이클로알킬, 사이클로알케닐, 바이사이클로알킬, 바이사이클로알케닐 및 트리사이클로알킬 라디칼은 불소원자로 치환될 수 있고, 당해 아릴 또는 헤테로아릴 라디칼은 할로겐, CN, (C1-C6)-알킬, (C3-C6)-사이클로알킬, O-(C1-C6)-알킬, S(O)m-(C1-C6)-알킬, SO2-NH2, COOH, CONH2, CO-O(C1-C6)-알킬, CO-(C1-C6)-알킬로 치환될 수 있으며, 여기서, 당해 알킬 라디칼은 불소원자로 치환될 수 있고, R6, R7, R8, R9 및 R10은 각각 독립적으로 R11, NR17-바이사이클릭 헤테로사이클, NR17-아릴 또는 NR17-헤테로아릴이고, 여기서, 당해 아릴 또는 헤테로아릴 라디칼은 5원 또는 6원의 방향족 또는 비방향족 탄소 환에 융합될 수 있으며, 이때 하나 이상의 CH 또는 CH2 그룹은 산소원자로 대체될 수 있고, 당해 5원 또는 6원의 방향족 또는 비방향족 탄소 환은 F, =O 또는 -(C1-C6)-알킬로 치환될 수 있으며, 당해 바이사이클릭 헤테로사이클은 9 내지 12개의 환 구성원을 함유할 수 있으며, 5개 이하의 CH 또는 CH2 그룹은 각각 독립적으로 N, NR20, O, S(O)m 또는 C=O로 대체될 수 있고, 당해 아릴 또는 헤테로아릴 라디칼, 또는 바이사이클릭 헤테로사이클은 치환되지 않거나, R11, F, Cl, Br, I, CN, N3, NC, NO2, CF3, (CH2)n-O-R11, (CH2)n-O-(CH2)r-OH, (CH2)n-O-CH(CH2OH)2, (CH2)n-O-(CH2)n-CO-O-(CH2)r-NH2, (CH2)n-O-(CH2)n-CO-NH-(CH2)r-OH, (CH2)n-O-당, (CH2)n-O-당 산(sugar acid), (CH2)n-O-글루코시드, (CH2)n-O-갈락토시드, (CH2)n-O-글루쿠로니드, O-R13, OCF3, (CH2)n-O-(CH2)r-NH2, (CH2)n-NH-R11, (CH2)n-N[(CH2)q-CO-O(C1-C6)-알킬]2, (CH2)n-N[(CH2)q-COOH]2, (CH2)n-N[(CH2)q-CONH2]2, (CH2)n-NH-R13, (CH2)n-N(R13)2, (CH2)n-NH-CN, (CH2)n-NH-SO2-R16, (CH2)n-NH-(CH2)n-SO2-R12, (CH2)n-NR12-CO-R16, (CH2)n-NR12-CO-NR12R13, (CH2)n-NR12-CO-N(R12)2, (CH2)n-NR12-CO-NHR11, (CH2)n-NH-C(=NH)-NH2, (CH2)n-NH-C(=NH)-R16, (CH2)n-NH-C(=NH)-NHR12, (CH2)n-NR12-C(=NR13)-NHR12, (CH2)n-NR12-C(=NR12)-NR12R13, (CH2)n-NH-(CH2)n-CO-O-(CH2)r-NH2, (CH2)n-NH-(CH2)n-CO-NH-[(C1-C8)-알킬], (CH2)n-NH-(CH2)n-CO-NH-(CH2)r-OH, (CH2)n-NH-(CH2)n-CO-N[(C1-C8)-알킬]2, (CH2)n-NH-(CH2)n-CO-NH-[(C3-C8)-사이클로알킬], (CH2)n-NH-(CH2)n-CO-N[(C3-C8)-사이클로알킬]2, (CH2)n-NH-C(CH3)2-CO-O(C1-C8)-알킬, (CH2)n-NH-C(CH3)2-CO-O(C3-C8)-사이클로알킬, (CH2)n-NH-C(CH3)2-CO-O-(CH2)r-NH2, (CH2)n-NH-C(CH3)2-CO-O-(CH2)n-아릴, (CH2)n-NH-C(CH3)2-CO-O-(CH2)n-헤테로아릴, (CH2)n-NH-C(CH3)2-CO-NH2, (CH2)n-NH-C(CH3)2-CO-NH-[(C1-C8)-알킬], (CH2)n-NH-C(CH3)2-CO-NH-(CH2)r-OH, (CH2)n-NH-C(CH3)2-CO-N[(C1-C8)-알킬]2, (CH2)n-NH-(CH3)2-CO-NH-[(C3-C8)-사이클로알킬], (CH2)n-NH-C(CH3)2-CO-N[(C3-C8)-사이클로알킬]2, (CH2)n-NH-C(CH3)2-COOH, S(O)m-R12, SO2-R16, SO2-N=CH-N(CH3)2, [이미지] ,SO2-NH-CO-R12, SO2-NHR12, SO2-NH-(CH2)r-OH, SO2-N[(C1-C8)-알킬]2, SO2-NH-(CH2)r-NH2, SF5, COOH, CO-NH2, (CH2)q-CN, (CH2)n-CO-NH-CN, (CH2)n-CO-NH-피페리딘-1-일, (CH2)n-CO-NH-SO2-NHR12, (CH2)n-CO-NH-SO2-R18, (CH2)n-CHO, (CH2)n-C(=NH)-NH2, (CH2)n-C(=NH)-NHOH, (CH2)n-C(=NH)-[NH-O-(C1-C6)-알킬], (CH2)n-C(=NH)(R16), (CH2)n-C(=NR13)NHR12, (CH2)n-C(=NR12)NR12R13 또는 (CH2)n-C(=NH)O[(C1-C6)-알킬](여기서, 당해 알킬 및 사이클로알킬 라디칼은 불소원자로 치환될 수 있으며, 당해 아릴 또는 헤테로아릴 라디칼은 할로겐, CN, (C1-C6)-알킬, (C3-C6)-사이클로알킬, O-(C1-C6)-알킬, S(O)m-(C1-C6)-알킬, SO2-NH2, COOH, CONH2, CO-O(C1-C6)-알킬 또는 CO-(C1-C6)-알킬로 치환될 수 있고, 여기서, 당해 알킬 라디칼은 불소원자로 치환될 수 있다), F, Cl, Br, I, CN, N3, NC, NO2, CF3, (CH2)n-O-R11, (CH2)n-O-(CH2)r-OH, (CH2)n-O-CH(CH2OH)2, (CH2)n-O-(CH2)n-CO-O-(CH2)r-NH2, (CH2)n-O-(CH2)n-CO-NH-(CH2)r-OH, (CH2)n-O-당, (CH2)n-O-당 산, (CH2)n-O-글루코시드, (CH2)n-O-갈락토시드, (CH2)n-O-글루쿠로니드, O-R13, OCF3, (CH2)n-NH-R11, (CH2)n-NH-R13, (CH2)n-NH-CN, (CH2)n-NH-SO2-R16, (CH2)n-NH-(CH2)n-SO2-R12, (CH2)n-NR12-CO-R16, (CH2)n-NR12-CO-NR12R13, (CH2)n-NR12-CO-N(R12)2, (CH2)n-NR12-CO-NHR11, (CH2)n-NH-C(=NH)-NH2, (CH2)n-NH-C(=NH)-R16, (CH2)n-NH-C(=NH)-NHR12, (CH2)n-NR12-C(=NR13)-NHR12, (CH2)n-NR12-C(=NR12)-NR12R13, (CH2)n-NH-(CH2)n-CO-O-(CH2)r-NH2, (CH2)n-NH-(CH2)n-CO-NH-[(C1-C8)-알킬], (CH2)n-NH-(CH2)n-CO-NH-(CH2)r-OH, (...