1-cycloalkyl- or 1-heterocyclyl-hydroxyimino-3-phenyl-propanesT his invention relates to novel 1-cycloalkyl- or l-heterocyclyl-hydroxyimino-3-phen propanes of the formula wherein R1 to R7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.The compound of formula iwhereinr 1c 4-7-cycloalkyl, described cycloalkyl is unsubstituted or is independently selected from that one, two or three group of the group that is made up of the following replaces: c 1-7-alkyl, hydroxyl, oxo base, dioxo base and c 1-7-alkyl-carbonyl; or heterocyclic radical, described heterocyclic radical has 4 to 7 annular atomses, comprises one, two or three heteroatomss being selected from n, o and s, and is unsubstituted or is independently selected from that one, two or three group of the group that is made up of the following replaces: c 1-7-alkyl, hydroxyl, oxo base, dioxo base and c 1-7-alkyl-carbonyl; r 2select the group of free the following composition: c 1-7-alkyl, c 3-7-cycloalkyl, c 2-7-thiazolinyl, halogen-c 1-7-alkyl, the phenyl that one, two or three group of the group that unsubstituted phenyl or be independently selected from is made up of the following replaces: c 1-7-alkyl, halogen, halogen-c 1-7-alkyl, halogen-c 1-7-alkoxyl group and c 1-7-alkyl sulphonyl, and heteroaryl, described heteroaryl is unsubstituted or by c 1-7-alkyl or oxo base replace, r 3and r 7be independently from each other the group being formed by the following: hydrogen, halogen and c 1-7-alkyl; and r 4, r 5and r 6group independently selected from being formed by the following: hydrogen,halogen, halogen-c 1-7-alkyl, cyano group, cyano group-c 1-7-alkyl, c 1-7-alkyl, c 3-7-thiazolinyl, c 1-7-alkynyl, c 1-7-alkoxyl group, c 1-7-alkoxy-c 1-7-alkyl, hydroxyl, hydroxyl-c 1-7-alkyl, hydroxyl-c 3-7-thiazolinyl, hydroxyl-c 3-7-alkynyl, hydroxyl-c 1-7-alkoxyl group, carboxyl, carboxyl-c 1-7-alkyl, carboxyl-c 3-7-thiazolinyl, carboxyl-c 1-7-alkynyl, carboxyl-c 1-7-alkoxyl group, tetrazyl,c 1-7-alkoxy carbonyl, c 1-7-alkyl sulphonyl, c 1-7-alkyl sulphonyl oxygen base, c 1-7-alkyl sulfonyl-amino, c 3-7-naphthene sulfamide base amino, amino-sulfonyl, (c 1-7-alkyl)-amino-sulfonyl, two-(c 1-7-alkyl)-amino-sulfonyl, heterocyclic radical alkylsulfonyl, c 1-7-alkyl-amino, two-(c 1-7-alkyl)-amino, c 1-7-alkoxy-c 1-7-alkyl-amino, c 1-7-alkoxy-c 1-7-alkyl-c 1-7-alkyl-amino, c 1-7-alkoxyl group-halogen-c 1-7-alkyl-amino, hydroxyl-c 1-7-alkyl-c 1-7-alkyl-amino, the amino acid, the c that connect by amino acid whose amino 3-7-cycloalkyl-amino, wherein c 3-7-cycloalkyl is unsubstituted or by hydroxyl, hydroxyl-c 1-7-alkyl or carboxyl substituted, carboxyl-c 1-7-alkyl-aminocarboxyl, carboxyl-c 1-7-alkyl-(c 1-7-alkyl)-aminocarboxyl, c 1-7-alkoxy carbonyl-c 1-7-alkyl-aminocarboxyl, c 1-7-alkyl-aminocarboxyl, two-(c 1-7-alkyl)-aminocarboxyl, c 1-7-alkyl sulphonyl-c 1-7-alkyl-aminocarboxyl, halogen-c 1-7-alkyl-aminocarboxyl, hydroxyl-c 1-7-alkyl-aminocarboxyl, hydroxyl-c 1-7-alkyl-c 1-7-alkyl-aminocarboxyl, halogen-hydroxyl-c 1-7-alkyl-aminocarboxyl, c 1-7-alkoxy-c 1-7-alkyl-aminocarboxyl, c 3-7-cycloalkyl amino carbonyl, wherein c 3-7-cycloalkyl is unsubstituted or by hydroxyl, hydroxyl-c 1-7-alkyl or carboxyl substituted, heterocyclic radical-aminocarboxyl, wherein heterocyclic radical is unsubstituted or by c 1-7-alkyl or oxo base replace, heterocyclic radical-c 1-7-alkyl-aminocarboxyl, wherein heterocyclic radical is unsubstituted or by c 1-7-alkyl or oxo base replace, hydroxyl-c 1-7-alkyl-aminocarboxyl-c 1-7-alkyl, c 1-7-alkoxy carbonyl-c 1-7-alkyl, two-(c 1-7-alkoxy carbonyl)-c 1-7-alkyl, c 1-7-alkyl-carbonyl-amino-c 1-7-alkyl amino-carbonyl, c 1-7-alkyl-carbonyl-amino, carboxyl-c 1-7-alkyl-carbonyl-amino, c 1-7-alkoxy carbonyl-c 1-7-alkyl-carbonyl-amino, c 3-7-cycloalkyl, wherein c 3-7-cycloalkyl is unsubstituted or by hydroxyl, hydroxyl-c 1-7-alkyl or carboxyl substituted, c 3-7-cycloalkyl-c 1-7-alkyl, wherein c 3-7-cycloalkyl is unsubstituted or by hydroxyl, hydroxyl-c 1-7-alkyl or carboxyl substituted, heterocyclic radical, described heterocyclic radical is unsubstituted or by c 1-7-alkyl, halogen, hydroxyl, hydroxyl-c 1-7-alkyl, c 1-7-alkoxyl group, oxo base, carboxyl, carboxyl-c 1-7-alkyl, c 1-7-alkoxy carbonyl, aminocarboxyl, c 1-7-alkyl sulphonyl, amino-sulfonyl, c 1-7-alkyl-carbonyl, carboxyl-c 1-7-alkyl-aminocarboxyl or hydroxyl alkylsulfonyl-c 1-7-alkyl-aminocarboxyl replaces, heterocyclic radical carbonyl, described heterocyclic radical is unsubstituted or by c 1-7-alkyl, halogen, hydroxyl, hydroxyl-c 1-7-alkyl, c 1-7-alkoxyl group, oxo base, carboxyl, carboxyl-c 1-7-alkyl or c 1-7-alkyl sulphonyl replaces, heteroaryl, described heteroaryl is unsubstituted or by c 1-7-alkyl, c 3-7-cycloalkyl, thp trtrahydropyranyl, carboxyl, carboxyl-c 1-7-alkyl, c 1-7-alkoxy-c 1-7-alkyl or c 1-7-alkoxy carbonyl replaces, phenyl oxygen base, wherein phenyl is unsubstituted or is selected from that one to three group of halogen or carboxyl replaces, andphenyl, described phenyl is that one to three group of the group of unsubstituted or selected free the following composition replaces: halogen, c 1-7-alkyl, hydroxyl, hydroxyl-c 1-7-alkyl, cyano group, cyano group-c 1-7-alkyl, amino, c 1-7-alkoxyl group, carboxyl, ca...
1-사이클로알킬- 또는 1-헤테로사이클릴-하이드록시이미노-3-페닐-프로판본 발명은 하기 화학식 I의 신규의 1-사이클로알킬- 또는 1-헤테로사이클릴-하이드록시이미노-3-페닐-프로판, 또는 이의 약학적으로 허용가능한 염에 관한 것이다: [화학식 I] 상기 식에서, R1 내지 R7은 본원 명세서 및 특허청구범위에서 정의된 바와 같다. 이러한 화합물은 GPBAR1 작용제이고, 따라서 제 2 형 당뇨병과 같은 질환 치료용 약제로서 유용할 수 있다.하기 화학식 I의 화합물, 또는 이의 약학적으로 허용가능한 염:[화학식 I][이미지]상기 식에서,R1은 C4-7-사이클로알킬[이때, 사이클로알킬은 비치환되거나 또는 C1-7-알킬, 하이드록시, 옥소, 다이옥소 및 C1-7-알킬카본일로 이루어진 군으로부터 독립적으로 선택된 1, 2 또는 3개의 기로 치환된다], 또는헤테로사이클릴[이때, 헤테로사이클릴은 4 내지 7개의 고리 원자를 갖고, N, O 및 S로부터 선택된 1, 2 또는 3개의 헤테로원자를 포함하며, 비치환되거나 또는 C1-7-알킬, 하이드록시, 옥소, 다이옥소 및 C1-7-알킬카본일로 이루어진 군으로부터 독립적으로 선택되는 1, 2 또는 3개의 기로 치환된다]이고;R2는, C1-7-알킬, C3-7-사이클로알킬, C2-7-알켄일, 할로겐-C1-7-알킬, 비치환된 페닐 또는 C1-7-알킬, 할로겐, 할로겐-C1-7-알킬, 할로겐-C1-7-알콕시 및 C1-7-알킬설폰일로 이루어진 군으로부터 독립적으로 선택된 1, 2 또는 3개의 기로 치환된 페닐, 및헤테로아릴[이때, 헤테로아릴은 비치환되거나 C1-7-알킬 또는 옥소로 치환된다]로 이루어진 군으로부터 선택되고;R3 및 R7은 서로 독립적으로 수소, 할로겐 및 C1-7-알킬로 이루어진 군으로부터 선택되고;R4, R5 및 R6은 독립적으로 수소, 할로겐, 할로겐-C1-7-알킬, 시아노, 시아노-C1-7-알킬, C1-7-알킬, C3-7-알켄일, C1-7-알킨일, C1-7-알콕시, C1-7-알콕시-C1-7-알킬, 하이드록시, 하이드록시-C1-7-알킬, 하이드록시-C3-7-알켄일, 하이드록시-C3-7-알킨일, 하이드록시-C1-7-알콕시, 카복실, 카복실-C1-7-알킬, 카복실-C3-7-알켄일, 카복실-C1-7-알킨일, 카복실-C1-7-알콕시, 테트라졸일, C1-7-알콕시카본일, C1-7-알킬설폰일, C1-7-알킬설폰일옥시, C1-7-알킬설폰일아미노, C3-7-사이클로알킬설폰일아미노, 아미노설폰일, (C1-7-알킬)-아미노설폰일, 다이-(C1-7-알킬)-아미노설폰일, 헤테로사이클일설폰일, C1-7-알킬-아미노, 다이-(C1-7-알킬)-아미노, C1-7-알콕시-C1-7-알킬-아미노, C1-7-알콕시-C1-7-알킬-C1-7-알킬-아미노, C1-7-알콕시-할로겐-C1-7-알킬-아미노하이드록시-C1-7-알킬-C1-7-알킬-아미노, 아미노산의 아미노기를 통해 부착된 아미노산,C3-7-사이클로알킬-아미노[이때, C3-7-사이클로알킬은 비치환되거나 하이드록시, 하이드록시-C1-7-알킬 또는 카복실로 치환된다],카복실-C1-7-알킬-아미노카본일, 카복실-C1-7-알킬-(C1-7-알킬)-아미노카본일, C1-7-알콕시카본일-C1-7-알킬-아미노카본일, C1-7-알킬-아미노카본일, 다이-(C1-7-알킬)-아미노카본일, C1-7-알킬설폰일-C1-7-알킬-아미노카본일, 할로겐-C1-7-알킬-아미노카본일, 하이드록시-C1-7-알킬-아미노카본일, 하이드록시-C1-7-알킬-C1-7-알킬-아미노카본일, 할로겐-하이드록시-C1-7-알킬-아미노카본일, C1-7-알콕시-C1-7-알킬-아미노카본일,C3-7-사이클로알킬아미노카본일[이때, C3-7-사이클로알킬은 비치환되거나 하이드록시, 하이드록시-C1-7-알킬 또는 카복실로 치환된다],헤테로사이클일-아미노카본일[이때, 헤테로사이클일은 비치환되거나 C1-7-알킬 또는 옥소로 치환된다],헤테로사이클일-C1-7-알킬-아미노카본일[이때, 헤테로사이클일은 비치환되거나 C1-7-알킬 또는 옥소로 치환된다],하이드록시-C1-7-알킬-아미노카본일-C1-7-알킬, C1-7-알콕시카본일-C1-7-알킬, 다이-(C1-7-알콕시카본일)-C1-7-알킬, C1-7-알킬카본일아미노-C1-7-알킬아미노카본일, C1-7-알킬카본일아미노, 카복실-C1-7-알킬카본일아미노, C1-7-알콕시카본일-C1-7-알킬카본일아미노,C3-7-사이클로알킬[이때, C3-7-사이클로알킬은 비치환되거나 하이드록시, 하이드록시-C1-7-알킬 또는 카복실로 치환된다], C3-7-사이클로알킬-C1-7-알킬[이때, C3-7-사이클로알킬은 비치환되거나 하이드록시, 하이드록시-C1-7-알킬 또는 카복실로 치환된다],헤테로사이클일[이때, 헤테로사이클일은 비치환되거나 C1-7-알킬, 할로겐, 하이드록시, 하이드록시-C1-7-알킬, C1-7-알콕시, 옥소, 카복실, 카복실-C1-7-알킬, C1-7-알콕시카본일, 아미노카본일, C1-7-알킬설폰일, 아미노설폰일, C1-7-알킬카본일, 카복실-C1-7-알킬-아미노카본일 또는 하이드록시설폰일-C1-7-알킬-아미노카본일로 치환된다],헤테로사이클일카본일[이때, 헤테로사이클일은 비치환되거나 C1-7-알킬, 할로겐, 하이드록시, 하이드록시-C1-7-알킬, C1-7-알콕시, 옥소, 카복실, 카복실-C1-7-알킬 또는 C1-7-알킬설폰일로 치환된다],헤테로아릴[이때, 헤테로아릴은 비치환되거나 C1-7-알킬, C3-7-사이클로알킬, 테트라하이드로피란일, 카복실, 카복실-C1-7-알킬, C1-7-알콕시-C1-7-알킬 또는 C1-7-알콕시카본일로 치환된다], 페닐옥시[이때, 페닐은 비치환되거나 할로겐 또는 카복실로부터 선택된 1 내지 3개의 기로 치환된다], 및 페닐[이때, 페닐은 비치환되거나 할로겐, C1-7-알킬, 하이드록시, 하이드록시-C1-7-알킬, 시아노, 시아노-C1-7-알킬, 아미노, C1-7-알콕시, 카복실, 카복실-C1-7-알킬, C1-7-알콕시-카본일, 테트라졸일, 카복실-C1-7-알킬-카본일아미노, C1-7-알콕시-카본일-C1-7-알킬-카본일아미노, C1-7-알킬설폰일, C1-7-알킬-설폰일아미노, 아미노설폰일, C1-7-알킬-아미노설폰일, 다이-(C1-7-알킬)-아미노설폰일, 헤테로사이클일설폰일, C1-7-알콕시카본일-C1-7-알콕시, C1-7-알콕시카본일-C1-7-알킬-아미노카본일, 카복실-C1-7-알킬-아미노카본일, C1-7-알콕시카본일-C1-7-알킬-카본일아미노-C1-7-알킬설폰일,페닐-C1-7-알킬-아미노카본일, 테트라졸일-아미노카본일,테트라졸일-C1-7-알킬-아미노카본일 및 카복실-C1-7-알킬-아미노카본일로 이루어진 군으로부터 선택된 1 내지 3개의 기로 치환된다]로 이루어진 군으로부터 선택된다.