Novel peptide derivatives and uses thereofThe invention provides for novel peptide derivatives and compositions comprising the same. The invention further provides methods of treatment comprising administering novel peptide derivatives and/or compositions comprising the same.A kind of compound of formula (i)：ra-xaa1-xaa2-xaa3-xaa4-xaa5-xaa6-xaa7-xaa8-xaa9-rb (i)it is characterized in that rait is h ,-(c1-c3)-alkyl ,-c (o)-(c1-c3)-alkyl or-c (o)-(c1-c3)-haloalkyl；rbit is rc；rcit is oh ,-n (rd)(r’d)、-(c3-c8)-aminocycloalkyl or-(c1-c6)-alkoxy；rd、r’dit independently is h, oh ,-(c1-c6)-alkyl ,-(c1-c3)-hydroxy alkyl ,-(c1-c6)-alkyl-n (re)(r’e)、- c(o)-(c1-c3)-haloalkyl, aryl or heteroaryl；re、r’eit independently is h ,-(c1-c6)-alkyl or-c (o)-(c1-c3)-haloalkyl；xaa1forr1、r11、r’11it independently is h ,-(c1-c3)-alkyl ,-c (o)-(c1-c3)-alkyl or-c (o)-(c1-c3)-alkyl halide base；n1it is the integer of 1-4；xaa2forx2it independently is nh, n (me), or2、r’2it independently is h ,-(c1-c3)-alkyl ,-c (o)-(c1-c3)-alkyl or-c (o)-(c1-c3)-haloalkyl；r22it independently is oh, halogen ,-(c1-c3)-alkyl ,-(c1-c3)-alkoxy, o-c (o)-(c1-c6)-alkyl or-o-c (o)-(c1-c6)-haloalkyl；n2it is the integer of 1-3；xaa3forx3it independently is n (r33)、or3it independently is h, halogen, nh2、-(c1-c6)-alkyl ,-(c1-c6)-haloalkyl ,-(c3-c8)-cycloalkyl ,-(c1- c6)-alkenyl ,-(c1-c6)-alkynyl ,-(c1-c6)-alkyl-or33、(c1-c6)-alkyl-sr33、(c1-c6)-alkyl-nr33r’33、 (c1-c6)-alkyl-c (o) nr33r’33、(c1-c6)-alkyl-c (o) or33、(c1-c6)-alkyl-heteroaryl, wherein the alkyl optionally by-oh or-o-c (o)-(c1-c6)-alkyl or-o-c (o)-(c1-c6)-haloalkyl replaces, wherein the heteroaryl is appointed choosing quilt-(c1-c3)-alkyl or (c1-c6)-alkyl-aryl-group replaces, wherein the aryl is optionally by-oh ,-(c1-c3)-alkyl ,- (c1-c3)-alkoxy or halogen replaces；r33、r’33、r”33it independently is h ,-c (nh) nh2、-(c1-c3)-alkyl ,-c (o)-(c1-c3)-alkyl or-c (o)-(c1- c3)-haloalkyl；r333、r’333、r”333、r”’333it independently is h, oh, halogen ,-(c1-c3)-alkyl ,-(c1-c3)-alkoxy ,-o-co- (c1-c3)-alkyl or-o-co- (c1-c3)-haloalkyl；n3it is the integer of 1-3；xaa4forx4it independently is nh, n (me), or4、r’4it independently is h ,-(c1-c3)-alkyl or-(c1-c3)-haloalkyl；xaa5forx5it independently is nh, n (me), or5、r’5it independently is h ,-(c1-c3)-alkyl ,-c (o)-(c1-c3)-alkyl or-c (o)-(c1-c3)-haloalkyl；r555、r’555、r”555、r”’555it independently is h, oh, halogen ,-(c1-c3)-alkyl or-(c1-c3)-alkoxy；n5it is the integer of 1-3；xaa6forx6it independently is n (r66)、or6it independently is h, halogen, nh2、-(c1-c6)-alkyl ,-(c1-c6)-haloalkyl ,-(c3-c8)-cycloalkyl ,-(c1- c6)-alkenyl ,-(c1-c6)-alkynyl ,-(c1-c6)-alkyl-or66、(c1-c6)-alkyl-sr66、(c1-c6)-alkyl-nr66r’66、 (c1-c6)-alkyl-c (o) nr66r’66、(c1-c6)-alkyl-c (o) or66、(c1-c6)-alkyl-heteroaryl, wherein the alkyl optionally by-oh or-o-c (o)-(c1-c6)-alkyl or-o-c (o)-(c1-c6)-haloalkyl replaces, wherein the heteroaryl is appointed choosing quilt-(c1-c3)-alkyl or (c1-c6)-alkyl-aryl-group replaces, wherein the aryl is optionally by-oh ,-(c1-c3)-alkyl ,- (c1-c3)-alkoxy or halogen replaces；r66、r’66it independently is h, oh, halogen ,-c (nh) nh2、-(c1-c3)-alkyl ,-(c1-c3)-haloalkyl ,-c (o)- (c1-c3)-alkyl ,-c (o)-(c1-c3)-haloalkyl ,-nh2、nh(c1-c3)-alkyl or n [(c1-c3)-alkyl] [(c1-c3)- alkyl]n6it is the integer of 0-3；xaa7forx7it independently is n (r77)、or7it is h ,-(c1-c6)-alkyl ,-(c1-c6)-haloalkyl ,-(c1-c6)-alkenyl ,-(c1-c6)-alkynyl ,-(c1-c6)-alkane base-or77、(c1-c6)-alkyl-sr77、(c1-c6)-alkyl-s (o)-r77、(c1-c6)-alkyl-s (o)2-r77、-(c1-c6)-alkane base-nr77r’77、-(c1-c6)-alkyl-c (o) or77、-(c1-c6)-alkyl-c (o) nr77r’77、-(c1-c6)-alkyl-heteroaryl or-(c1-c6)-alkyl-aryl-group, wherein aryl or heteroaryl are optionally by-oh ,-nh2、-cooh、-conh2、-cn、-cf3、-(c1- c6)-alkyl ,-(c1-c3)-alkoxy or halogen is monosubstituted or polysubstituted；r77、r’77it independently is h, oh, halogen ,-(c1-c3)-alkyl ,-(c1-c3)-haloalkyl ,-c (o)-nh2、-c(nh)- nh2、-c(o)-(c1-c3)-alkyl ,-c (o)-(c1-c3)-haloalkyl ,-nh2、nh(c1-c3)-alkyl or n [(c1-c3)-alkane base] [(c1-c3)-alkyl]；n7it is the integer of 0-3；xaa8forx8it independently is nh, n (me), o；r8、r’8it independently is h ,-(c1-c3)-alkyl ,-c (o)-(c1-c3)-alkyl or-c (o)-(c1-c3)-haloalkyl；r88、r’88、r”88、r”’88it independently is h, oh- (c1-c3)-alkyl ,-(c1-c3)-alkoxy or halogen；n8it independently is the integer of 1-4；xaa9forx9it independently is nh, n (me), or9、r’9it independently is h ,-c (nh) nh2、-c(o)nh2、-(c1-c6)-alkyl ,-(c1-c6)-haloalkyl ,-c (o)- (c1-c3)-alkyl or-c (o)-(c1-c3)-haloalkyl；r99it is h or-(c1-c3)-alkyl；r99it is h or-(c1-c3)-alkyl；n9it independently is the integer of 1-3；or its pharmaceutically acceptable salt.
신규의 펩티드 유도체 및 그 용도본 발명은 신규의 펩티드 유도체 및 이를 포함하는 조성물을 제공한다. 본 발명은 신규의 펩티드 유도체 및/또는 이를 포함하는 조성물의 투여를 포함하는 치료 방법을 추가로 제공한다.하기를 특징으로 하는, 식 (I) 의 화합물 또는 그 약학적으로 허용가능한 염: Ra-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Rb (I)[식 중, Ra 는 H, -(C1-C3)-알킬, -C(O)-(C1-C3)-알킬, 또는 -C(O)-(C1-C3)-할로알킬이고;Rb 는 Rc 이고;Rc 는 OH, -N(Rd)(R'd), -(C3-C8)-아미노시클로알킬, 또는 -(C1-C6)-알콕시이고;Rd, R'd 는 독립적으로 H, OH, -(C1-C6)-알킬, -(C1-C3)-히드록시알킬, -(C1-C6)-알킬-N(Re)(R'e), -C(O)-(C1-C3)-할로알킬, 아릴 또는 헤테로아릴이고;Re, R'e 는 독립적으로 H, -(C1-C6)-알킬, 또는 -C(O)-(C1-C3)-할로알킬이고;Xaa1 는 [이미지] 이고, R1, R11, R'11 은 독립적으로 H, -(C1-C3)-알킬, -C(O)-(C1-C3)-알킬, 또는 -C(O)-(C1-C3)-할로알킬이고;n1 은 1-4 의 정수이고;Xaa2 는 [이미지] 이고;X2 는 독립적으로 NH, N(Me), O 이고,R2, R'2 는 독립적으로 H, -(C1-C3)-알킬, -C(O)-(C1-C3)-알킬, 또는 -C(O)-(C1-C3)-할로알킬이고;R22 는 독립적으로 OH, 할로겐, -(C1-C3)-알킬, -(C1-C3)-알콕시, O-C(O)-(C1-C6)-알킬 또는 -O-C(O)-(C1-C6)-할로알킬이고;n2 는 1-3 의 정수이고;Xaa3 은 [이미지][이미지] 이고;X3 은 독립적으로 N(R33), O 이고;R3 은 독립적으로 H, 할로겐, NH2, -(C1-C6)-알킬, -(C1-C6)-할로알킬, -(C3-C8)-시클로알킬, -(C1-C6)-알케닐, -(C1-C6)-알키닐, -(C1-C6)-알킬-OR33, (C1-C6)-알킬-SR33, (C1-C6)-알킬-NR33R'33, (C1-C6)-알킬-C(O)NR33R'33, (C1-C6)-알킬-C(O)OR33, (C1-C6)-알킬-헤테로아릴 (이때, 상기 알킬은 -OH 또는 -O-C(O)-(C1-C6)-알킬 또는 -O-C(O)-(C1-C6)-할로알킬로 임의 치환되고, 상기 헤테로아릴은 -(C1-C3)-알킬로 임의 치환됨), 또는 (C1-C6)-알킬-아릴 (이때, 상기 아릴은 -OH, -(C1-C3)-알킬, -(C1-C3)-알콕시 또는 할로겐으로 임의 치환됨) 이고;R33, R'33, R"33 은 독립적으로 H, -C(NH)NH2, -(C1-C3)-알킬, -C(O)-(C1-C3)-알킬, 또는 -C(O)-(C1-C3)-할로알킬이고;R333, R'333, R"333, R"'333 은 독립적으로 H, OH, 할로겐, -(C1-C3)-알킬, -(C1-C3)-알콕시, -O-CO-(C1-C3)-알킬 또는 -O-CO-(C1-C3)-할로알킬이고;n3 은 1-3 의 정수이고;Xaa4 는 [이미지] 이고;X4 는 독립적으로 NH, N(Me), O 이고;R4, R'4 는 독립적으로 H, -(C1-C3)-알킬, 또는 -(C1-C3)-할로알킬이고;Xaa5 는 [이미지] 이고;X5 는 독립적으로 NH, N(Me), O 이고;R5, R'5 는 독립적으로 H, -(C1-C3)-알킬, -C(O)-(C1-C3)-알킬, 또는 -C(O)-(C1-C3)-할로알킬이고;R555, R'555, R"555, R"'555 는 독립적으로 H, OH, 할로겐, -(C1-C3)-알킬, 또는 -(C1-C3)-알콕시이고;n5 는 1-3 의 정수이고;Xaa6 은 [이미지][이미지] 이고;X6 은 독립적으로 N(R66), O 이고;R6 은 독립적으로 H, 할로겐, NH2, -(C1-C6)-알킬, -(C1-C6)-할로알킬, -(C3-C8)-시클로알킬, -(C1-C6)-알케닐, -(C1-C6)-알키닐, -(C1-C6)-알킬-OR66, (C1-C6)-알킬-SR66, (C1-C6)-알킬-NR66R'66, (C1-C6)-알킬-C(O)NR66R'66, (C1-C6)-알킬-C(O)OR66, (C1-C6)-알킬-헤테로아릴 (이때, 상기 알킬은 -OH 또는 -O-C(O)-(C1-C6)-알킬 또는 -O-C(O)-(C1-C6)-할로알킬로 임의 치환되고, 상기 헤테로아릴은 -(C1-C3)-알킬로 임의 치환됨), 또는 (C1-C6)-알킬-아릴 (이때, 상기 아릴은 -OH, -(C1-C3)-알킬, -(C1-C3)-알콕시 또는 할로겐으로 임의 치환됨) 이고;R66, R'66 은 독립적으로 H, OH, 할로겐, -C(NH)NH2, -(C1-C3)-알킬, -(C1-C3)-할로알킬, -C(O)-(C1-C3)-알킬, -C(O)-(C1-C3)-할로알킬, -NH2, NH(C1-C3)-알킬, 또는 N[(C1-C3)-알킬][(C1-C3)-알킬] 이고;n6 은 0-3 의 정수이고;Xaa7 은 [이미지] 이고;X7 은 독립적으로 N(R77), O 이고;R7 은 H, -(C1-C6)-알킬, -(C1-C6)-할로알킬, -(C1-C6)-알케닐, -(C1-C6)-알키닐, -(C1-C6)-알킬-OR77, (C1-C6)-알킬-SR77, (C1-C6)-알킬-S(O)-R77, (C1-C6)-알킬-S(O)2-R77, -(C1-C6)-알킬-NR77R'77, -(C1-C6)-알킬-C(O)OR77, -(C1-C6)-알킬-C(O)NR77R'77, -(C1-C6)-알킬-헤테로아릴 또는 -(C1-C6)-알킬-아릴 (이때, 아릴 또는 헤테로아릴은 -OH, -NH2, -COOH, -CONH2, -CN, -CF3, -(C1-C6)-알킬, -(C1-C3)-알콕시 또는 할로겐으로 임의 일 또는 다치환됨) 이고;R77, R'77 은 독립적으로 H, OH, 할로겐, -(C1-C3)-알킬, -(C1-C3)-할로알킬, -C(O)-NH2, -C(NH)-NH2, -C(O)-(C1-C3)-알킬, -C(O)-(C1-C3)-할로알킬, -NH2, NH(C1-C3)-알킬, 또는 N[(C1-C3)-알킬][(C1-C3)-알킬] 이고;n7 은 0-3 의 정수이고;Xaa8 은 [이미지] 이고;X8 은 독립적으로 NH, N(Me), O 이고; R8, R'8 은 독립적으로 H, -(C1-C3)-알킬, -C(O)-(C1-C3)-알킬, 또는 -C(O)-(C1-C3)-할로알킬이고; R88, R'88, R"88, R"'88 은 독립적으로 H, OH, -(C1-C3)-알킬, -(C1-C3)-알콕시, 또는 할로겐이고; n8 은 독립적으로 1-4 의 정수이고;Xaa9 는 [이미지] 이고;X9 는 독립적으로 NH, N(Me), O 이고;R9, R'9 는 독립적으로 H, -C(NH)NH2, -C(O)NH2, -(C1-C6)-알킬, -(C1-C6)-할로알킬, -C(O)-(C1-C3)-알킬, 또는 -C(O)-(C1-C3)-할로알킬이고; R99 는 H, 또는 -(C1-C3)-알킬이고;R99 는 H, 또는 -(C1-C3)-알킬이고;n9 는 독립적으로 1-3 의 정수임].