NOVEL ANTIVIRAL COMPOUNDSThe invention relates to novel compounds of the Formula (I), to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.A kind of compound indicated by formula (i):it its enantiomter, diastereoisomer, tautomer, n- oxide, solvate, preparation and its can pharmaceutically connect the salt received, whereinx is selected fromr1selected from hydrogen, halogen, c1-6alkyl, halogenated-c1-6alkyl, c3-6naphthenic base, halogenated-c3-6naphthenic base ,-o-c1-6alkane halogenated-the c of base ,-o-1-6alkyl and-nh-c1-6alkyl；condition is when x isone of in the case where, r1it cannot be hydrogen (h)；r2selected from h ,-cn ,-no2、c1-10alkyl, c2-10alkenyl, c2-10alkynyl, c0-10alkylene-c3-10naphthenic base, c0-10- alkylene-c3-10heterocyclylalkyl, c0-10alkylene-(5- to 10- unit's heteroaryl), c0-10alkylene-(6- to 10- member virtue base), c0-10alkylene-(6- to 10- unit's heteroaryl), c0-10alkylene-or11、c0-10alkylene-co2r11、c0-10sub- hydrocarbon base-c (=o) nr11r12、c0-10alkylene-c (=s) nr11r12、c0-10alkylene-c (=o) nr11so2r13、c0-10sub- hydrocarbon base-c (=s) nr11so2r11、c0-10alkylene-c (=o) r11、c0-10alkylene-c (=s) r11、c0-10alkylene-sr11、 c0-10alkylene-soxr13、c0-10alkylene-so3r11、c0-10alkylene-so2nr11r12、c0-10alkylene-nr11c (=o) r11、c0-10alkylene-nr11c (=s) r11、c0-10alkylene-nr11so2r13、c0-10alkylene-nr11c (=o) nr11r12、 c0-10alkylene-nr11c (=s) nr11r12、c0-10alkylene-nr11so2nr11r12、c0-10alkylene-nr11r12, wherein alkane base, alkenyl, alkynyl, alkylene, naphthenic base, heterocyclylalkyl, aryl and heteroaryl are unsubstituted or are independently selected by 1 to 7 free oxo, cn ,-no2、or11、o-c2-6alkylene-or11、c1-6alkyl, halogenated-c1-6alkyl, halogen, co2r11, c (= o)nr11r12, c (=o) nr11so2r11, c (=o) r11、sr11、soxr11、so3r11, p (=o) (or11)2、so2nr11r12、nr11c (=o) r11、nr11so2r13、nr11c (=o) nr11r12、nr11so2nr11r12、c3-10naphthenic base, o-c3-10naphthenic base, c3-10- heterocyclylalkyl, o-c3-10heterocyclylalkyl and nr11r12the substituent group of the group of composition replaces；r3selected from h, c1-6alkyl, halogenated-c1-6alkyl ,-o-c1-6halogenated-the c of alkyl ,-o-1-6alkyl, c3-6naphthenic base and c3-6heterocyclylalkyl, wherein alkyl, naphthenic base and heterocyclylalkyl are optionally by 1-5 independently selected from halogen ,-cn, oh, oxygen generation, c1-3alkyl, halogenated-c1-3alkyl, o-c1-3halogenated-the c of alkyl, o-1-3alkyl, so2-c1-3alkyl, co2the substituent group of h replace；or work as r2and r3nitrogen connected to them together when, formed containing carbon atom and optionally containing 1 or 2 be selected from o, s or the heteroatomic 3- of n to 8- member ring, wherein the ring be it is unsubstituted or by 1 to 4 independently selected from by halogen ,-cn ,- no2, oh, oxo, c1-3alkyl, halogenated-c1-3alkyl, o-c1-3halogenated-the c of alkyl, o-1-3alkyl, so2-c1-3alkyl, co2the substituent group of the group of h composition replaces；r4selected from h, c1-6alkyl, c1-6acyl group, c2-6alkenyl, c3-8naphthenic base and c3-8heterocyclylalkyl, wherein alkyl, acyl base, alkenyl, naphthenic base and heterocyclylalkyl are optionally by 1 to 5 independently selected from halogen ,-cn, oh, oxo, c1-3alkyl, halogen generation-c1-3alkyl, o-c1-3halogenated-the c of alkyl, o-1-3the substituent group of alkyl replaces；r5and r6and r5' and r6' independently selected from h, halogen, c1-6alkyl, nh2、nhc1-6alkyl, n (c1-6alkyl)2、 c0-6alkylene-c (=o) nh2；or work as r5and r6and r5' and r6' carbon connected to them together when, be separately formed containing carbon atom and optionally contain have 1 or 2 heteroatomic 3- selected from o, s or n to 8- member ring, wherein the ring be unsubstituted or by 1 to 4 independently select free halogen ,-cn ,-no2, oh, oxo, c1-3alkyl, halogenated-c1-3alkyl, o-c1-3halogenated-the c of alkyl, o-1-3alkane base, so2-c1-3alkyl, co2the substituent group of the group of h composition replaces；work as r5and r5' and r6and r6' two adjacent carbons connected to them together when, be separately formed containing carbon atom, and heteroatomic 3- optionally containing 1 or 2 selected from o, s or n to 8- member ring, wherein the ring be unsubstituted or by 1 to 4 solely on the spot select free halogen ,-cn ,-no2, oh, oxo, c1-3alkyl, halogenated-c1-3alkyl, o-c1-3halogenated-the c of alkyl, o-1-3- alkyl, so2-c1-3alkyl, co2the substituent group of the group of h composition replaces；r7selected from 6 yuan of aryl and 5- or 6- unit's heteroaryl, wherein aryl and heteroaryl are optionally by 1-4 independently selected from halogen element ,-cn ,-no2、oh、c1-6alkyl, o-c1-6alkyl, c3-6naphthenic base, o-c3-6naphthenic base, c3-6heterocyclylalkyl, o- c3-6heterocyclylalkyl, soy-c1-6alkyl, co2h, c (=o) o-c1-6alkyl, 6- to 10- member aryl, 5- or 10- unit's heteroaryl, the substituent group of o- (6- to 10- member aryl) and o- (5- or 10- unit's heteroaryl) replaces, whereinalkyl, naphthenic base, heterocyclylalkyl, aryl and heteroaryl are optionally by 1-5 independently selected from halogen ,-cn ,-no2、oh、 r13、or13、co2r11、nr11r12, c (=o) r11, c (=s) r11, c (=o) nr11r12、nr11c (=o) nr11r12、nr11c (=o) or13, oc (=o) nr11r12, c (=s) nr11r12、nr11c (=s) nr11r12、n...
항바이러스제로서 유용한 아미노티아졸 유도체본 발명은 신규한 화학식 (I)의 화합물, 그것의 제조 방법 및 그것의 약제로서, 특히 항바이러스 약제로서의 용도에 관한 것이다.[이미지]화학식 (I)로 표시되는 화합물, 그것의 거울상 이성질체, 부분입체 이성질체, 호변 이성질체, N-산화물, 용매화물, 제형 및 약학적으로 허용 가능한 염:[이미지]여기서,X는 [이미지], [이미지], [이미지], [이미지], [이미지], [이미지], [이미지], [이미지], [이미지] 및 [이미지]로부터 선택되고,R1은 H, 할로겐, C1-6-알킬, 할로-C1-6-알킬, C3-6-사이클로알킬, 할로-C3-6-사이클로알킬, -O-C1-6-알킬, -O-할로-C1-6-알킬 및 -NH-C1-6-알킬로부터 선택되고;단, X가 [이미지], [이미지] 및 [이미지] 중의 하나라는 전제하에, R1은 수소(H)가 아니고;R2는 H, -CN, -NO2, C1-10-알킬, C2-10-알케닐, C2-10-알키닐, C0-10-알킬렌-C3-10-사이클로알킬, C0-10-알킬렌-C3-10-헤테로사이클로알킬, C0-10-알킬렌-(5- 내지 10-원 헤테로아릴), C0-10-알킬렌-(6- 내지 10-원 아릴), C0-10-알킬렌-(6- 내지 10-원 헤테로아릴), C0-10-알킬렌-OR11, C0-10-알킬렌-CO2R11, C0-10-알킬렌-C(=O)NR11R12, C0-10-알킬렌-C(=S)NR11R12, C0-10-알킬렌-C(=O)NR11SO2R13, C0-10-알킬렌-C(=S)NR11SO2R11, C0-10-알킬렌-C(=O)R11, C0-10-알킬렌-C(=S)R11, C0-10-알킬렌-SR11, C0-10-알킬렌-SOxR13, C0-10-알킬렌-SO3R11, C0-10-알킬렌-SO2NR11R12, C0-10-알킬렌-NR11C(=O)R11, C0-10-알킬렌-NR11C(=S)R11, C0-10-알킬렌-NR11SO2R13, C0-10-알킬렌-NR11C(=O)NR11R12, C0-10-알킬렌-NR11C(=S)NR11R12, C0-10-알킬렌-NR11SO2NR11R12, C0-10-알킬렌-NR11R12로부터 선택되며, 여기서 알킬, 알케닐, 알키닐, 알킬렌, 사이클로알킬, 헤테로사이클로알킬, 아릴 및 헤테로아릴은 치환되지 않거나, 옥소, CN, -NO2, OR11, O-C2-6-알킬렌-OR11, C1-6-알킬, 할로-C1-6-알킬, 할로겐, CO2R11, C(=O)NR11R12, C(=O)NR11SO2R11, C(=O)R11, SR11, SOxR11, SO3R11, P(=O)(OR11)2, SO2NR11R12, NR11C(=O)R11, NR11SO2R13, NR11C(=O)NR11R12, NR11SO2NR11R12, C3-10-사이클로알킬, O-C3-10-사이클로알킬, C3-10-헤테로사이클로알킬, O-C3-10-헤테로사이클로알킬 및 NR11R12로 이루어지는 군으로부터 독립적으로 선택되는 1 내지 7개의 치환기로 치환되고;R3은 H, C1-6-알킬, 할로-C1-6-알킬, -O-C1-6-알킬, -O-할로-C1-6-알킬, C3-6-사이클로알킬 및 C3-6-헤테로사이클로알킬로부터 선택되며, 여기서 알킬, 사이클로알킬 및 헤테로사이클로알킬은 할로겐, -CN, OH, 옥소, C1-3-알킬, 할로-C1-3-알킬, O-C1-3-알킬, O-할로-C1-3-알킬, SO2-C1-3-알킬, CO2H로부터 독립적으로 선택되는 1 내지 5개의 치환기로 선택적으로 치환되고; 또는 R2 및 R3은 그것들이 부착되는 질소와 함께, 탄소 원자를 함유하고 O, S 또는 N으로부터 선택되는 1 또는 2개의 헤테로원자를 선택적으로 함유하는 3- 내지 8-원 고리를 완성하며, 여기서 고리는 치환되지 않거나 할로겐, -CN, -NO2, OH, 옥소, C1-3-알킬, 할로-C1-3-알킬, O-C1-3-알킬, O-할로-C1-3-알킬, SO2-C1-3-알킬, CO2H로 이루어지는 군으로부터 독립적으로 선택되는 1 내지 4개의 치환기로 치환되고;R4는 H, C1-6-알킬, C1-6-아실, C2-6-알케닐, C3-8-사이클로알킬 및 C3-8-헤테로사이클로알킬로부터 선택되며, 여기서 알킬, 아실, 알케닐, 사이클로알킬 및 헤테로사이클로알킬은 할로겐, -CN, OH, 옥소, C1-3-알킬, 할로-C1-3-알킬, O-C1-3-알킬, O-할로-C1-3-알킬로부터 독립적으로 선택되는 1 내지 5개의 치환기로 선택적으로 치환되고;R5 및 R6 및 R5' 및 R6'는 H, 할로겐, C1-6-알킬, NH2, NHC1-6-알킬, N(C1-6-알킬)2, C0-6-알킬렌-C(=O)NH2로부터 독립적으로 선택되고; 또는 R5 및 R6 및 R5' 및 R6'는 독립적으로 그것들이 부착되는 탄소와 함께, 탄소 원자들을 함유하고 O, S 또는 N으로부터 선택되는 1 또는 2개의 헤테로원자를 선택적으로 함유하는 3- 내지 8-원 고리를 완성하며, 여기서 고리는 치환되지 않거나 할로겐, -CN, -NO2, OH, 옥소, C1-3-알킬, 할로-C1-3-알킬, O-C1-3-알킬, O-할로-C1-3-알킬, SO2-C1-3-알킬, CO2H로 이루어지는 군으로부터 독립적으로 선택되는 1 내지 4개의 치환기로 치환되고; 또는 R5 및 R5' 및 R6 및 R6'는 독립적으로 그것들이 부착되는 2개의 인접한 탄소와 함께, 탄소 원자들을 함유하고 O, S 또는 N으로부터 선택되는 1 또는 2개의 헤테로원자를 선택적으로 함유하는 3- 내지 8-원 고리를 독립적으로 형성하며, 여기서 고리는 치환되지 않거나 할로겐, -CN, -NO2, OH, 옥소, C1-3-알킬, 할로-C1-3-알킬, O-C1-3-알킬, O-할로-C1-3-알킬, SO2-C1-3-알킬, CO2H로 이루어지는 군으로부터 독립적으로 선택되는 1 내지 4개의 치환기로 치환되고;R7은 6-원 아릴 및 5- 또는 6-원 헤테로아릴로부터 선택되며, 여기서 아릴 및 헤테로아릴은 할로겐, -CN, -NO2, OH, C1-6-알킬, O-C1-6-알킬, C3-6-사이클로알킬, O-C3-6-사이클로알킬, C3-6-헤테로사이클로알킬, O-C3-6-헤테로사이클로알킬, SOy-C1-6-알킬, CO2H, C(=O)O-C1-6-알킬, 6- 내지 10-원 아릴, 5- 또는 10-원 헤테로아릴, O-(6- 내지 10-원 아릴) 및 O-(5- 또는 10-원 헤테로아릴)로부터 독립적으로 선택되는 1 내지 4개의 치환기로 선택적으로 치환되고, 여기서알킬, 사이클로알킬, 헤테로사이클로알킬, 아릴 및 헤테로아릴은 할로겐, -CN, -NO2, OH, R13, OR13, CO2R11, NR11R12, C(=O)R11, C(=S)R11, C(=O)NR11R12, NR11C(=O)NR11R12, NR11C(=O)OR13, OC(=O)NR11R12, C(=S)NR11R12, NR11C(=S)NR11R12, NR11C(=S)OR13, OC(=S)NR11R12; SOy-C1-6-알킬, SOy-할로-C1-6-알킬, SR11, SOxR13, SO3R11, SO2NR11R12, NR11SO2R13, NR11SO2NR11R12로부터 독립적으로 선택되는 1 내지 5개의 치환기로 선택적으로 치환되고;R8은 H, -CN, -NO2, C1-10-알킬, C2-10-알케닐, C2-10-알키닐, C0-10-알킬렌-C3-10-사이클로알킬, C0-10-알킬렌-C3-10-헤테로사이클로알킬, C0-10-알킬렌-(5 내지 10-원 헤테로아릴), C0-10-알킬렌-(6 내지 10-원 아릴), C0-10-알킬렌-(6 내지 10-원 헤테로아릴), C0-10-알킬렌-OR11, C0-10-알킬렌-CO2R11, C0-10-알킬렌-C(=O)NR11R12, C0-10-알킬렌-C(=S)NR11R12, C0-10-알킬렌-C(=O)NR11SO2R13, C0-10-알킬렌-C(=S)NR11SO2R11, C0-10-알킬렌-C(=O)R11, C0-10-알킬렌-C(=S)R11, C0-10-알킬렌-SR11, C0-10-알킬렌-SOx-R13, C0-10-알킬렌-SO3R11, C0-10-알킬렌-SO2NR11R12, C0-10-알킬렌-NR11C(=O)R11, C0-10-알킬렌-NR11C(=S)R11, C0-10-알킬렌-NR11SO2R11, C0-10-알킬렌-NR11C(=O)NR11R12, C0-10-알킬렌-NR11C(=S)NR11R12, C0-10-알킬렌-NR11-SO2-NR11R12, C0-10-알킬렌-NR11R12로부터 선택되고, 여기서 알킬, 알케닐, 알키닐, 알킬렌, 사이클로알킬, 헤테로사이클로알킬, 아릴 및 헤테로아릴은 치환되지 않거나 옥소, CN, -NO2, OR11, O-C2-6-알킬렌-OR11, C1-6-알킬, 할로-C1-6-알킬, 할로겐, CO2R11, CONR11R12, CONR11SO2R11, COR11, SOxR11, SO3H, PO(OH)2, SO2NR11R12, NR11COR11, NR11SO2R11, NR11-CO-NR11R12, NR11-SO2-NR11R12, C3-10-사이클로알킬, O-C3-10-사이클로알킬, C3-10-헤테로사이클로알킬, O-C3-10-헤테로사이클로알킬 및 NR11R12로 이루어지는 군으로부터 독립적으로 선택되는 1 내지 7개의 치환기로 치환되고;R9는 C1-10-알킬, C2-10-알케닐, C2-10-알키닐, C0-10-알킬렌-C3-10-사이클로알킬, C0-10-알킬렌-C3-10-헤테로사이클로알킬, C0-10-알킬렌-(5- 내지 10-원 헤테로아릴), C0-10-알킬렌-(6- 내지 10-원 아릴), C0-10-알킬렌-(6- 내지 10-원 헤테로아릴), C0-10-알킬렌-OR11, C0-10-알킬렌-CO2R11, C0-10-알킬렌-C(=O)NR11R12, C0-10-알킬렌-C(=S)NR11R12, C0-10-알킬렌-C(=O)NR11SO2R13, C0-10-알킬렌-C(=S)NR11SO2R11, C0-10-알킬렌-C(=O)R11, C0-10-알킬렌-C(=S)R11, C0-10-알킬렌-SR11, C0-10-알킬렌-SOxR13, C0-10-알킬렌-SO3R11, C0-10-알킬렌-SO2NR11R12, C0-10-알킬렌-NR11C(=O)R11, C0-10-알킬렌-NR11C(=S)R11, C0-10-알킬렌-NR11SO2R13, C0-10-알킬렌-NR11C(=O)NR11R12, C0-10-알킬렌-NR11C(=S)NR11R12, C0-10-알킬렌-NR11SO2NR11R12, C0-10-알킬렌-NR11R12로부터 선택되고, 여기...