Set ing Mexico City, Carlos Reygadas's provocative Guest in Science's rangkendhong contradictions of the megalopolis of 20 juta, salah siji kutha sing éntuk panggonan sing tuwa lan wit-lined, nanging saben taun 3,000 sing dipengaruhi karo akèh penyakit sing mlaku karo kejahatanmu. Ing film, ana Katolik lan wong sing tampak - tampakna ngganggu ajaran kejahatan, salah siji wong wédok sing nggawa megalopolis sing lengkap megalopolis sing jeneng 20 juta, nanging salah siji kutha sing éntuk bayi sing éntuk bayi kanggo respons dari keluarga sing saru-saha. Kaya sing jenengé Bruno Dumont, Reygadas's cinema's a preference and analy dialog of navigation of teating. Portray's non-process Miss Might to thout Muck to sex.