Amerikan Desi nerangké crita Krishna (Kris) Gopal Reddy, an umuré 18 taun American Desi (Desi slang kanggo Indian, kuwi saka tembung Desh sing tegesé tanah utawa negara), lan telung room-rumé Desi ing koleh. Jagjit kuwi salah siji caramu FOB (Fresh of the Boat), Ajay's the thuged who "think hell", Saleem's the ultra-conservative Muslim and Kris are the role of a coosing with the Indian rooms. Sakjané karaktermu-niang mung ding film sing digambarké ing Indian-American.