Cartoon karakter Bullwinkle Moose (voice of Keith Scott, sing uga suarané narator) lan Rocket J. Squirrel (voice of June Foray) dipindho keluar dari kebutuhan sing ora musnah nganggo perky, agen FBI Sympathie (Piper Perabo) kanggo nglawan archis-enemies, Boris (Jason Alexander), Natasha (Rene Russo) and Fearless Leader (Robert De Niro) wektu digawari dadi donya nyata. Lider's maniacal's rencana Karen Sympathie (Piper Perabo) sing ora mung ngganggu ucap kosong kono, gambar koyo.