Welsh Language Minister Alun Davies has written to the corporation seeking assurances over the future of factual and drama production in Wales.
BBC Studios has announced plans to cut about 300 staff across the UK.
Its director Mark Linsey said the proposals will help "provide even greater value to licence fee payers".
BBC Studios is a recent created division of the BBC which encompasses its in-house TV programme making in genres such as drama, factual and entertainment.
Mr Davies, who has responsibility for the Welsh Government's broadcasting policy, said: "I was extremely concerned to learn of this announcement and its implications for the BBC in Wales, especially the loss of 27 jobs."
The minister said he supported the Bectu union as it seeks assurances the redundancies will be achieved through voluntary means.
In a letter to BBC Director General Lord Hall, Mr Davies said: "Throughout the BBC Charter Review process, the Welsh Government has expressed concern about the BBC Studios proposal.
"We are not persuaded that a significant scaling back of BBC in-house production - which may well be the outcome of an entirely market driven approach to commissioning within the BBC - would be beneficial overall."
Mark Linsey, director of BBC Studios, said: "A strong, creative and competitive BBC Studios is crucial to maintaining the BBC's role as one of the world's great programme makers and ensuring that in-house production at the BBC has a secure future.
"With the removal of an in-house guarantee, we need to be able to develop programmes and projects for a variety of broadcasters, and compete effectively for the finest talent.
"The changes announced [on Thursday] will help us to reshape in response to a new landscape and provide even greater value to licence fee payers."

The man named as Abdalfatah HA is suspected of being part of a unit with an al-Qaeda-linked group formerly known as al-Nusra Front, which killed 36 Syrian government employees in 2013.
The federal prosecutors' office said the man, arrested in Duesseldorf, had carried out death sentences.
A second suspected al-Nusra fighter was arrested in the town of Giessen.
Abdulrahman AA is accused of breaking international weapons laws.
Both are thought to have been part of the same combat unit for al-Nusra, which was al-Qaeda's affiliate in Syria at the time.
The group formally severed its ties to the global jihadist network last year, renaming itself Jabhat Fateh al-Sham.
In January, JFS merged with four smaller groups to form Hayat Tahrir al-Sham.
German prosecutors allege Abdulrahman AA, 26, and Abdalfatah HA, 35, took part in an armed battle against Syrian government troops including taking over a big arms depot near Mahin, central Syria, in November 2013, eight months after the murders of the government employees.
Some local reports have claimed one of the men was an asylum seeker, but a spokeswoman for the prosecutors' office refused to confirm this.
The Welsh Government has said it was "extremely concerned" over news of 27 job cuts in Wales by the BBC's production arm, BBC Studios.
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A Syrian national has been arrested in Germany accused of war crimes involving the murder of dozens of civil servants.