Some 1,500 officers have been deployed to the Olympic Stadium area, authorities have said.
Officials are in high alert following Tuesday's attacks in Brussels.
Last year, a friendly between Germany and the Netherlands in Hannover was called off two hours before its start due to a security threat, four days after the Paris attacks.
One of the targets in Paris was the Stade de France, where Germany were playing France in a friendly match.
Some 72,000 people are expected to attend Saturday's match in Berlin between two of the favourites for June's Euro 2016.
In the hours ahead of the game, fans gathered around the stadium amid a heavy security presence.
They face security checks and bag searches before entering the arena.
"This is of course a very large event drawing lots of people. Like all large events, there is a certain risk involved, so we are well prepared," Berlin police spokesman Stefan Redlich told Reuters news agency.
"We searched the Olympic stadium with dogs trained to sniff out explosives before we let the fans in. So we can be relatively certain that there are no dangerous objects in the stadium."

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14 January 2015 Last updated at 18:28 GMT
The carriage has spent four months at Locomotion, the National Railway Museum in Shildon.
It took the World War Two prime minister's coffin from London to Oxfordshire in 1965.
The restoration cost about Â£30,000.
Look North's Ian Reeve reports.

Staffordshire Police said officers were called at 03:55 BST to the southbound carriageway, between junction 16 for Crewe/Stoke-on-Trent and 15 for Stoke-on-Trent.
The man was taken to hospital where he remains in a critical condition.
The southbound stretch was closed after the crash and reopened at about 10:00. Motorists were warned of delays during the morning.
See more updates on this story and others from across Staffordshire and Cheshire here
West Midlands Ambulance Service said the man, believed to be in his 20s, was lying on the hard shoulder when crews arrived.
Spokesman Jamie Arrowsmith said: "He had suffered multiple serious injuries and was suffering from a reduced level of consciousness.
"The man received specialist trauma care at the scene before being anaesthetised in order to stabilise his condition.
"He was then transported to Royal Stoke University Hospital on blue lights and sirens for further emergency treatment."

Gunners Joseph Rowbottom, 27, from Wrawby, North Lincolnshire, and Albert Venus, 22, from Hull, died on 24 May 1915 during the Second Battle of Ypres.
Their remains were found during work on a new housing estate.
Relatives attended Ypres Town Cemetery where their bodies were reinterred, in coffins draped with the union jack.
The soldiers' remains, with shoulder titles from the North and East Riding Batteries of the RFA, were uncovered in the town in April 2013.
Ministry of Defence (MoD) researchers were only able to identify the two men of the six found.
Gunner Venus's great nephew John Howden, 73, from Roos, East Yorkshire, was handed the folded union jack that had draped his coffin.
He said: "When they handed me the flag I had a lump in my throat and tears in my eyes and I did not think it would affect me that way.
"You are at a distance and all of a sudden you're involved and it's near, it's just emotional."
Mr Howden said he had not known about his great uncle until he got a letter from the MoD.
He said he was pleased the link was proved following a DNA test.
Caroline Rowbottom, Gunner Rowbottom's cousin's granddaughter, received the flag on behalf of his relations.
Mrs Rowbottom, from Brigg, North Lincolnshire, said it had been a shock when the family received an MoD letter.
"Up until that point we did not even know of his existence - we did not have him in the family tree, which is very sad.
"The ceremony itself was very moving and very well put together," she said.
The traditional five-gun salute did not take place due to the heightened security level in the country in the wake of last month's attacks in Brussels.
Gunner Rowbottom had been a milkman before the war and was nicknamed Milky Joe in the local newspapers.
Gunner Venus enlisted in the 2nd Northumbrian Brigade in December 1914 and joined the Hull Batteries to complete his training as a gunner.
Security is tight in the German capital, Berlin, Germany host England in a friendly football match.
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A railway carriage that carried Sir Winston Churchill's coffin to his final resting place has been restored in County Durham.
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Six British soldiers who fought in the First World War have been given military burials more than a century after they were killed in Belgium.