International Trade Secretary Liam Fox will travel from the US to meet Mexican counterparts to discuss trading relationships.
Foreign Secretary Boris Johnson is on a two-day tour of Australia, saying post-Brexit trade is "top of the agenda".
And Brexit Secretary David Davis will hold private talks in Germany ahead of the next round of negotiations.
The globetrotting by the three ministers - dubbed the "three Brexiteers" for their role in backing a Leave vote - comes amid increased scrutiny of the opportunities and challenges facing Britain in terms of negotiating free trade agreements with other countries once it leaves the EU.
No deals can be done until withdrawal in March 2019 but the UK has established a series of inter-ministerial working groups in the US and Australia to discuss the way ahead while also signalling to other countries, such as New Zealand, that they will be "near the front of the queue".
US President Donald Trump has said a deal with the UK could be "big and exciting" in terms of jobs, accusing the EU of a "very protectionist" stance towards America.
The EU has insisted Brexit talks will only be held by the European Commission, and the Department for Exiting the European Union confirmed Mr Davis' talks with officials in Germany would be private.
Brussels has also made clear that trade talks between the UK and the EU must wait until other issues, including the status of expats and any "divorce bill" to be paid by the UK, have been settled.
The role of the European Court of Justice has emerged as a stumbling block to a deal on citizen's rights, despite both sides insisting that they want to come an arrangement.
The UK is seeking a "comprehensive free trade deal" with the EU after Brexit to replace its membership of the common market and customs union.

Joe Anderson's plans include reducing call centre opening hours, reviewing libraries and increasing the number of "in-house" foster carers.
He also suggests opening car parks longer and introducing a premium service for bulky item collections to raise funds.
The proposals will be discussed by the city council's cabinet on 24 February.
Mr Anderson said reducing council call centre hours could save £2.9m and cutting the number of One Stop Shops - where people can get advice on council services or pay their council tax - could draw back £2.7m.
However, he said that would mean it will "take people longer to get a response to requests for some services".
His plan sets out a saving of £4.1m in children's services, which would be achieved by reducing the cost of care placements and packages by using fewer independent foster agencies.
It also includes reducing the cost of the city's economic development agency, Liverpool Vision, by £1.2m and reviewing of the city's library provision to save £1.6m - a move which could see several close.
The budget also proposes a 4.99% council tax increase - the mayor previously suggested a one-off rise of 10% but that was rejected by Liverpool residents during a public consultation.
Mr Anderson said the cuts would mean job losses, stating that there was "no doubt that some frontline council services will be significantly reduced and we will have less staff by 2020".
"These are not things that we want to do, but we have no choice, because the government isn't listening," he said.
Joe Anderson's set out his budget, which would save £90m.
Big cuts to adult social care have been minimised - for the moment at least - and the impact of paying the national living wage has turned out to be less costly than was originally budgeted for. The city has also made money through the mayor's flagship Invest To Earn programme, which is generating £3m a year.
New homes are generating an additional £8m per year in council tax revenue - an amount that could rise with the building of executive homes in south Liverpool, as the vast majority of the city's housing stock is currently in the lowest bands.
Mr Anderson says he's setting up a task force to consider the future of the city's libraries - he expects about four will have to close in order to make the savings - and there is also doubt over the future of the One Stop Shops.
But there are also areas where the council is seeking to invest, including in street cleaning, where £2m will be spent, and £1.5m has also been allocated to improve leisure facilities.
Senior cabinet ministers will push the UK's Brexit agenda on three different continents later.
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Liverpool's mayor has proposed a budget cut of £90m over the next three years, which could see about 300 jobs lost.