The Chancellor will meet finance minister Wolfgang Schaeuble to set out more details of the UK's bid to renegotiate its EU membership.
Securing German backing is important for the success of British plans for reform.
David Cameron has already courted support from Chancellor Angela Merkel.
Mr Osborne said: "The UK and German economies are the beating heart of Europe, the engine for growth and jobs.
"Together we make the world's third-largest economy, behind only America and China, and since the crisis ended, we have generated two-thirds of EU growth.
"But the future holds challenges for our economies. We must cut debt and boost productivity. To do this, we need a strong EU, fit for today's challenges and working for the benefit of all 28 member states.
"The UK's reform and renegotiation plans aim to achieve this, which is why these talks with key partners in Europe are so important."
Mr Osborne will also visit a Siemens factory in the German capital and address an audience of business leaders at the annual conference of the BDI, the Federation of German Industries.
In May Germany's Chambers of Commerce and Industry warned that a UK exit from the EU would be "disastrous" for the two countries.
Volker Treier, deputy chief executive of the organisation, told the BBC that German business was "astonished" that the UK was planning a referendum on its EU membership.
David Cameron's renegotiation plans will be formally debated for the first time by the EU's 28 leaders at a summit in Brussels in mid-December.

The local authority has spent more than £750,000 on events since 2014.
In total, 18 different organisations have received support for 38 events which attracted combined attendances of more than 160,000 people.
The council report added that more than 43% of audiences had come from outside Dumfries and Galloway.
The study was undertaken to assess the effectiveness of the local authority's Major Festivals and Events Strategy (MFES).
Among the events it has supported are Wigtown Book Festival, Spring Fling and the Dumfries and Galloway Arts Festival.
A survey found there was good public awareness of the strategy, with 85% of respondents saying the events benefited their community.
The majority also said it had helped to provide a "favourable impression" of the council.
The review concluded that the strategy had "generally met its objectives" in terms of supporting the development of the events sector in Dumfries and Galloway.
"The region is increasingly recognised for the breadth and depth of events across a number of sectors staged within its borders each year," it said.
"These contribute significantly to the regional economy as well as to the quality of life of our population."
However, the study did flag up concerns about policing costs at some music festivals in the region.
A meeting is to be held at the end of the month to try to tackle the issue.
The British and German economies are the "beating heart" of Europe, George Osborne has said as he heads to Berlin for talks on reforming the EU.
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A report has found festivals supported by a three-year council investment strategy have generated £17.6m for the Dumfries and Galloway economy.