The details emerged during the sentencing of Arshid, Bannaras and Basharat Hussain at Sheffield Crown Court.
Arshid, 40, and Basharat, 39, were found guilty by a jury of 50 offences.
Bannaras, 36, pleaded guilty to 10 offences before the trial started.
Michelle Colborne QC said Bannaras Hussain met one victim when she was 12 or 13 and she performed sex acts on him.
"He was indifferent to whether she consented or not," she said.
"When her brothers found out, they were furious with her and would physically assault her because she was involved sexually with an Asian man."
She said Bannaras abused one victim in a car park next to Rotherham Police Station, and told the court how the sister of another of his victims described her sister as a "broken human being".
Ms Colborne said one woman had described the Hussain brothers as "a pack of animals".
Summing up the contents of a number of statements from the women abused by the brothers, she said: "They describe from their teenage years a life in the main of feeling dirty, ashamed and guilty.
"Between them, a plethora of emotional conditions - eating disorders, self-harm, agoraphobia, self-loathing and terminations for many of them from the age of 14 - events they have never been able to put behind them."
She said many of the victims have had relationship problems throughout their lives and have found themselves subjected to domestic violence.
Three associates of the Hussain brothers, their uncle Qurban Ali, 53, Karen MacGregor, 58, and Shelley Davies, 40, will also be sentenced.
Ali was found guilty of conspiracy to rape, while MacGregor and Davies were convicted of false imprisonment and conspiracy to procure a woman under 21 to become a common prostitute. MacGregor was also convicted of two counts of conspiracy to rape.

Remus Hamza, 41, of Riverside, Cardiff, was jailed for 12 years in February 2016 for raping the 20-year-old and was also given four years on extended licence.
He took his case to the Court of Appeal in London, arguing this was too severe.
But judges said his appeal was "totally without merit" and gave him an extra 28 days in prison for wasting court time.
Hamza claimed he had consensual sex with his victim, but was found guilty after a trial.
He had also previously exposed himself to three young women in the same area.
The woman was walking home along Museum Avenue in the early hours of 20 September 2015 after losing her friends while on a night out.
Hamza grabbed her and raped her in nearby bushes. He fled after a passer-by spotted him and called the police.
Judge Sarah Munro QC said the victim suffered serious psychological harm as a result of the attack.
Hamza's lawyers argued the crown court judge made the wrong assessment of how serious his crime was and did not take enough account of the fact he would have to serve two thirds of his jail term before his release can be considered.
Dismissing his appeal, Judge Munro said it was "not arguable" the sentence was excessive.
She added: "The provisions relating to early release and licence should be left out of the picture when determining sentence. There is no merit whatsoever in this appeal."
A victim of one of three brothers who raped and sexually assaulted 15 teenage girls in Rotherham was attacked by her own family when they discovered the abuse, a court has heard.
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A rapist who attacked a student as she walked home during freshers' week has been given an extended sentence.