The Crues will retain the Gibson Cup if they beat the Lurgan Blues on Saturday and Linfield fail to defeat Coleraine.
"We must stay focused, it's definitely not over yet and we still have a job to do," said Crues manager Stephen Baxter.
"It's important that we come away from this game with something to push us a little closer to the title."
"We had a fantastic game against Glenavon in the Irish Cup a couple of weeks ago, which could have gone either way.
"We just have to concentrate on playing the games in front of us and focus on what we are trying to do."
"We will go there with confidence after our big win over Linfield last week but we now face two testing away games and Mourneview Park is a difficult place to go," added Baxter.
Second-placed Linfield now trail the champions by eight points and Blues manager David Healy has all but conceded defeat in his club's pursuit to overhaul the pacesetters with just four rounds of fixtures remaining.
"We now have to make sure we finish second and seal a European place," commented Healy.
"Credit to Crusaders as it's often said that it's more difficult to retain a title than to win it so well done to them if they do go on and win it.
"We have a cup final to look forward to and I've told the squad that they are playing for starting places in the team for that."
Glenavon will hope to bounce back from last week's reverse at the hands of Cliftonville, a result which saw Gary Hamilton's side drop below the Reds in the contest to clinch third position.
The Solitude outfit entertain Glentoran, who will be without injured pair Calum Birney (ankle) and Chris Lavery (knee).
The battle for valuable points to help avoid the drop continues at the foot of the table as bottom side Warrenpoint Town host Ballinamallard United, who are one point ahead of Barry Gray's charges in 11th.
Tenth-placed Carrick Rangers are one point better off than the Mallards but are at home to a Ballymena United side, who are now unbeaten in five matches under new boss David Jeffrey.
Struggling Portadown play Dungannon Swifts in the day's other Section B fixture.

It follows a decision by the city's three further education colleges to join a national pay bargaining system.
Members of the EIS union at other colleges across Scotland are due to strike on Tuesday and Wednesday in a separate dispute over pay.
The Glasgow lecturers may now be balloted to decide if they join future action in the wider pay dispute.
The Glasgow lecturers had joined a one-day strike on Thursday, prior to the local pay bargaining dispute being settled.
EIS general secretary Larry Flanagan said a "U-turn" by the Glasgow colleges marked a "significant early victory in the campaign for fair pay in all Scottish colleges".
He said: "The Glasgow colleges had refused to sign up to the national bargaining process, in the mistaken belief that this would remove them from their obligations on a fair pay offer.
"The strike action by our members has forced a quick change of mind on the part of the Glasgow colleges, and the EIS welcomes this development today."
Mr Flanagan added, "While these Glasgow disputes are now settled the national action in pursuit of a fair national pay offer and pay equality in all colleges will continue.
"Two days of strike action in this campaign are planned for next week, and these will take place in all colleges where lecturers have been balloted as part of the national dispute.
"Lecturers in the three Glasgow colleges, who are not currently part of the national action, will now be re-balloted as soon as possible to allow them to join their colleagues across Scotland in future strike days as part of the national campaign for fair pay."
Crusaders continue their bid to secure back-to-back Irish League titles for the first time in their history when they face Glenavon at Mourneview Park.
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Lecturers at colleges in Glasgow will not take part in two planned national strikes next week.