The event takes place at East Kirkcarswell Farm near Dundrennan on 25 and 26 July.
Dizzee Rascal will headline the opening night in his only Scottish festival appearance of the year.
Organisers have also unveiled a string of other acts including Martha Reeves and The Vandellas, The Zombies, Big Country and The Feeling.
Wickerman Festival co-ordinator Helen Chalmers said she was "thrilled" to be revealing the first acts.
"We are delighted that Dizzee Rascal will be joining the party this year, his live performances are incredible and I can't wait to see the crowd's reaction to his headline set," she said.
"From hip hop, pop, folk to Motown and alternative rock, this year's line-up will once again be a truly diverse offering.
"We look forward to announcing further exciting additions including our Saturday night headliner over the coming weeks."

The fire, which is being treated as deliberate, was first reported at about 11:00 BST on Sunday.
Eight fire appliances and 45 fire fighters are at the scene, including crew members from the Irish Fire Service.
The blaze has spread across a 5 kilometre area, crossing the border.
It is the latest of 435 reported wildfires since the beginning of May.
Group Commander Brian Stanfield said: "We believe this fire has been started deliberately and we believe there are still people in the area qho are starting fires.
"We'd like to appeal to members of the public. This is reckless behaviour, this is not just endangering the countryside, but it is putting people's lives and property at risk."

Restrictions are in place between 11:00 and 18:00 on two sections of Fishergate and were introduced on a trial basis on 31 October 2016 to reduce congestion.
Misuse of the lane has seen over 23,000 drivers receive £60 penalty notices.
A Lancashire County Council spokesman said almost 16,000 had already paid their fines and the restrictions would continue until a review in April.
Roger Lawson, from the Association of British Drivers, said bus lanes were "discriminatory" and without any actual benefits.
Councillor John Fillis said the changes, which are in place from Mount Street to Corporation Street and at the Butler Street junction, had had a "big effect" in reducing traffic levels over the festive period.
He said there was a "growing consensus that the measures worked" and as a result, he had "decided that the bus lane should stay at least until we are able to assess how the changes work at different times of year".
"We definitely don't want to issue any £60 penalty charge notices, but it is an important way for us to enforce these changes," he added.
"The aim is to help to reduce traffic build-up that has affected parts of the city centre at the busiest times."
Mr Lawson said bus lanes "don't encourage people to get on the bus".
"These arguments [about reducing congestion] are specious and used to attack the use of private vehicles," he added.

The firm successfully completed operational trials of the Train 2 unit ahead of it receiving shale gas ethane from the US this autumn.
New docks and a new pipeline network have been built to receive the gas.
The company said the move means it is now in "great shape" to run the plant at full capacity.
The KG ethylene cracker was unable to operate at full capacity in 2008, leaving Ineos "no option" but to close the second manufacturing unit.
Ineos said the US ethane will be used as a supplementary feed for the KG ethylene plant and will allow the plant to run at increased rates.
Gordon Milne, Ineos Grangemouth operations director, said: "With the successful completion of the Train 2 trial we are now in great shape to receive shale gas from the US and to finally run the Grangemouth plant at full rates.
"All the parts of the jigsaw are finally coming together and Grangemouth will soon be back in the premier league of European petrochemical plants."
The plant's chief executive John McNally said: "Bringing the site back into profitability is the best way to secure our future here in Scotland.
"We know that ethane from US shale gas has transformed US manufacturing and we are now a step closer to seeing this advantage being brought to here to Grangemouth."
Rapper Dizzee Rascal has been announced as one of the headline acts at this year's Wickerman Festival.
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The Northern Ireland Fire and Rescue Service (NIFRS) is attending a gorse fire in Alderwood Road near Clogher and Fivemiletown in County Tyrone.
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More than £1.3m in fines were issued in the two months after a new bus lane was introduced in Preston city centre.
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A second manufacturing unit at the Ineos KG ethylene plant in Grangemouth will be brought back to life eight years after it was mothballed.