Cardiff University's School of Pharmacy and Pharmaceuticals plans to add medicinal salmonella-killing herbs to the fermented honey drink.
The tipple is based on a 16th century Welsh drink called metheglin.
"You can see this would sell very well to students," Prof Les Baillie said.
"Perhaps you could protect them from the kebab and the morning after."
Dr James Blaxland, who has led the work, tested more than 50 different plants extracts and hops against a range of bacteria, including salmonella.
It is one of the germs that trigger more than 500,000 cases in the UK each year.
"It causes very serious food poisoning and stomach upset, which people might experience on a Sunday morning," Dr Blaxland said.
"The idea is that we can produce a mead with high levels of the compounds which are active against salmonella, and, if people drink enough of our mead on a Saturday night, they might not get ill."
Cardiff University's team said the idea was sparked by Scandinavian scientists who are trying to develop mead which could help in the battle against antibiotic resistance.
Adding medicinal herbs to mead dates back at least four centuries, when Welsh brewers created a drink then called metheglin or meddyglyn.
"We still have to do a lot of work on this, and a lot more sampling has to be done before we come up with the finished drink," he said.
In addition to developing the mead, researchers are also investigating the of possibility using hops-based compounds to prevent other human illnesses.
They are also hoping to use hops commonly only utilised in beer to tackle the problem of bovine tuberculosis and even to eliminate methane produced by cows and cut global warming.

Jamie Cox was sentenced to 26 weeks for common assault after he attacked Viktoria Gribovskaja at her home in Lambeth, south London last year.
The Swindon-based WBO European super-middleweight title holder had denied assault.
His sentence was suspended at an appeal at Croydon Magistrates' Court.
The 29-year-old boxer, who appeared in court under his real name Jamie Russan was told his conviction still stands, but that his prison sentence will be suspended for 18 months.
Recorder Joseph Boothby told him he should treat the suspended sentence as "a turning point" and said: "Change your ways and think before you get angry with a girlfriend, or anyone else for that matter."
Cox had been sentenced to 26 weeks in prison for the assault and harassment charges, 20 weeks for violence to secure entry and 12 weeks for criminal damage, to run concurrently.
He is currently ranked number four in the world and is also a Commonwealth Games light welterweight champion.
After the hearing, Cox said: "I just want to get back to normal and to fight for world titles. I do not really treat today as a success."

Asif Kahn, who worked at Oldknow Academy in Birmingham, had faced allegations of misconduct.
A National College of Teaching and Leadership panel heard the allegations against him in November, although Mr Khan did not appear at the hearing.
The Professional Conduct Panel has said it did not find the case proven.
Oldknow Academy was one of several schools investigated amid claims of a Muslim hardliners' plot to control them; known as the Trojan Horse affair.
More on this and other stories from Birmingham and the Black Country
Mr Khan had been accused of agreeing "to the inclusion of an undue amount of religious influence in the education of pupils" at Oldknow, on or before 31 July 2014.
The accusations had included telling some male pupils to change for PE in a cupboard so they would not show their thighs, banning children singing during a production of The Wizard of Oz and turning his back on a woman as she offered to shake his hand.
He was also accused of sharing his personal beliefs with the children, for example telling the children they were not allowed pet dogs as they were Muslim.
A fellow teacher, former-acting head teacher Jahangir Akbar, was banned from teaching indefinitely in January, although he can apply to have his ban set aside in five years time.

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Scientists are working on a Welsh "super mead" which could protect drinkers from the scourge of food poisoning at the late-night takeaway.
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