Polling stations opened at 07:00 BST in the area's 11 constituencies: Chester, Congleton, Warrington North, Warrington South, Halton, Ellesmere Port, Tatton, Crewe & Nantwich, Eddisbury, Macclesfield and Weaver Vale.
Votes will be counted after the polls close at 22:00 BST.
For the latest news from all the counts in Cheshire, go to our election live service.
Results will also be available on your constituency profile page.

The Reds led in the 15th minute when Divock Origi flicked in from close range before Roberto Firmino made it 2-0, heading in Nathaniel Clyne's cross.
Origi also went close when his low shot was saved by Stephen Bywater.
Tom Naylor inadvertently put the ball in his own net after the break before Daniel Sturridge tapped in his first and then thumped home the Reds' fifth.
Liverpool manager Jurgen Klopp made only four changes from the XI that started in the 2-0 league defeat at Burnley on Saturday.
The quality of the visiting team was soon apparent at the Pirelli Stadium against a Burton side who have had a mixed start to their first ever season in the Championship.
After Liverpool's Belgian forward Origi cleverly profited from tricky work in the box from Sadio Mane, Brazilian Firmino doubled the lead following a terrible throw-out from goalkeeper Bywater.
It was 3-0 just after the hour when the unfortunate Naylor had little time to react as James Milner's ball came towards him at pace.
And substitute Sturridge then grabbed a late double, converting at the far post from Milner's pass before firing in low from 15 yards.
Liverpool manager Jurgen Klopp: "There were still a few situations where we were missing a bit of sharpness but the main problem was, it was unbelievable, our build-up and style of play at Burnley - one more pass but 15 times we are completely free in the box.
"So we needed to use this game and that's what we did and it was better."
Burton manager Nigel Clough: "It's difficult for our lads to compete with that sort of quality. With this being 72 hours before the Derby game, our focus was always with that one.
"When you think we finished with a couple of teenagers and a 20- or 21-year-old, you could train with them for a couple of seasons and not gain the experience they've got tonight."

The 30-year-old Scot was sent off after 20 minutes of the Exiles' 45-14 loss to Bath on Saturday.
Meanwhile, Wasps prop Lorenzo Cittadini has been given a one-week ban after pleading guilty to punching Gloucester back Billy Twelvetrees on Sunday.
Saracens' Jacques Burger has been given a one-week ban for bad sportsmanship.

The businessman has been at the helm at the St Lawrence Ground since 2008.
Last year he clashed with the England and Wales Cricket Board (ECB) when his side were overlooked for promotion after Durham's enforced relegation.
Kent were Division Two runners-up, in most seasons normally a promotion spot, but the ECB decided instead to reprieve Hampshire from being relegated.
Kennedy said: "I've really enjoyed the challenge of helping the club navigate through some tricky times but I firmly believe Kent cricket is in much better health than it was in 2008.
"Last season gave us a glimpse of what could be achieved and I know that the club is in good hands.
"I'd like to thank all the members and supporters for their loyalty, patience and understanding and look forward to seeing Kent thrive in all competitions under (head coach) Matt Walker and (captain) Sam Northeast."
He added: "Relations with the ECB have been difficult with the advent of T20 discussions, and the battle over promotion and relegation along with various other issues, but I am happy to hand over to a new regime who will continue the work to return Kent to the top table."
Under Kennedy, Kent had voted against the ECB's proposed T20 city franchise scheme.
His reign saw the club record a £1m improvement in its finances through cost-cutting, and increased sponsorship and ticket revenues.
He will leave the club following its AGM on 28 March.
People are voting in Cheshire in the general and local council elections.
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A strong Liverpool side overwhelmed Championship outfit Burton Albion to reach the EFL Cup third round.
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London Irish scrum-half Brendan McKibbin has been suspended for three weeks by the Rugby Football Union for stamping on Bath's Henry Thomas.
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Kent chairman George Kennedy is to leave his position at the Championship Division Two club at the end of March.