North Wales Police and Crime Commissioner Arfon Jones said a so-called "fix room" could reduce drug deaths and the spread of infection.
He said the proposed plan came in response to Rhosddu residents' concerns over dumped hypodermic needles.
Mr Jones' comments come after a similar facility was recently announced for Glasgow.
The Glasgow centre, which will be the first of its kind in the UK, will aim to address the problems caused by users who inject on the city's streets.
Similar schemes already operate in 10 other countries, including Australia, Germany, France, Holland and Switzerland.
Mr Jones said: "At the moment, all you're getting is the authorities treating the symptoms of substance abuse and drug addiction rather than the underlying causes.
"Drug addiction should be treated as a public health issue rather than as a criminal matter."
If given the go-ahead, he said the rooms could also offer "wrap around" services such as health care, counselling, housing and welfare advice.
He said he also wanted to see a heroin-assisted treatment centre, which would see "chaotic" addicts prescribed medicinal heroin to help them beat their addiction.
He added this would also help tackle low-level street drug dealing.
Mr Jones said he was in discussion with members of Wrexham council about how such a project could work.
He added: "This approach would be better for those suffering from the blight of addiction, society in general and the residents of Rhosddu in particular.
"The people who make a good living out of drugs are the organised criminals. They are the people we need to be going after with all our might."

Five independent commissioners will provide recommendations to deal with violence against the country's indigenous women.
Indigenous Affairs Minister Carolyn Bennett announced the inquiry at an emotional ceremony in Gatineau, Quebec.
The inquiry will last at least two years and cost up to $53.8m (£30.8m).
Though the federal government has launched the commission, each province has agreed to allow the commissioners to look at all jurisdictions, including whether local law enforcement or governments played a part.
The commission will also have the authority to summon witnesses to testify.
The investigation is expected to focus on the systemic causes of violence against indigenous women as well as recommendations on prevention.
A 2015 United Nations report revealed that young indigenous women in Canada were five times more likely to die under violent circumstances than non-Aboriginal women.
Families of victims have argued that police do not investigate missing indigenous women with the same scrutiny for cases involving white women.
The five commissioners are Marion Buller, British Columbia's first female First Nations judge; Michele Audette, a former president of the Native Women's Association of Canada; Qajaq Robinson, a Nunavut-born lawyer who focuses on aboriginal law; Marilyn Poitras, a law professor at the University of Saskatchewan; and Brian Eyolfson, a First Nations lawyer who served on the Human Rights Tribunal of Ontario.
The investigation is set to begin in September and will run through 31 December, 2018.
BBC reporter Joanna Jolly went on the trail of the murdered and missing to find out why so many of Winnipeg's Aboriginal women and girls have been killed. Read full article
Calls have been made for a room in Wrexham where heroin users can inject safely under supervision.
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Canada has launched an investigation into missing and murdered indigenous women that will cost nearly C$14m (£8m) more than expected.