The leading index closed down 69.63 points at 6231.89.
Miners more than doubled earlier losses to leave Antofagasta down more than 6%. Others, including Anglo American and BHP Billiton were down 4%.
HOusebuilders all but wiped out their earlier falls. Taylor Wimpey ended flat and Berkeley Group ended less than 1% down after a report from chartered surveyors forecasted a short-term drop in UK house prices over the next three months.
Rolls-Royce was also a loser, with a 2% fall.
The chief executive of Rolls-Royce has warned staff that the engineering firm is behind with deliveries to customers, according to the Financial Times.
Vodafone fell about 5% after it agreed a deal to merge its New Zealand operations with Sky Network Television.
On the FTSE 250 builder Bellway was also caught in the general decline of construction shares, with a 1% fall.
That was despite an upbeat trading statement.
"That survey from RICS [Royal Institution of Chartered Surveyors] about a first possible drop in house prices since 2012, is clearly spooking people," said Russ Mould, investment director at AJ Bell.
"It is tax-related and maybe a little bit Brexit related, but some will be wondering whether there are more fundamental factors slowing us down, as prices are just at such high levels."
Flybe shares ended 5.5% lower, despite returning to profit.
On the currency markets, the pound was down 0.3% against the dollar at $1.4466 but rose 0.3% against the euro to â‚¬1.277.

Graham Andrew bought the 33,600-piece Wildlife puzzle and recruited 200 jigsaw fans to complete it, to raise money for local charities.
He was left with four holes in the giant puzzle and had to ask the Barcelona manufacturer to re-cut them.
The pieces have arrived and the puzzle should be completed on Friday.
Volunteers began piecing together the 5.7m (18.7ft) by 1.57m (5ft) picture of jungle creatures at a hall in Reepham on 14 August.
Click here for more news, bit by bit, from Norfolk
It was almost complete two weeks later, but, as reported by ITV, four pieces were missing.
"Four out of 33,000 isn't that bad," Mr Andrew told the BBC.
"I had bought a second puzzle just in case this happened. We sifted through for ages to find the pieces, and I was thrilled when we did."
However, Mr Andrew realised the jigsaws were not identical and the back-up pieces did not fit.
"I considered squishing them in, but decided it had to be done properly so I asked the company to re-cut them," he said.
He had to send the surrounding pieces to the Spanish company so they could accurately make replacements.
It is not yet known how the pieces went missing, but he said they probably fell into a handbag or "got stuck on a granny's cardigan" as she was helped out.
Mr Andrew raised funds for the Norfolk and Norwich Hospital children's wards and Reepham nursery by asking people to sponsor puzzle pieces.
The jigsaw will be displayed at the hospital and also taken to Addenbrooke's Hospital in Cambridge.
(Close): A fall in mining shares hit the main indexes in London, with the FTSE 100 closing down more than 1%.
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An attempt at what is said to be the largest jigsaw puzzle on the market was nearly scuppered when four pieces went missing "somewhere in Norfolk".