The channel's signed a deal with 20th Century Fox to show new episodes of Family Guy from later this year.
The agreement also includes other Seth MacFarlane animated comedies American Dad, The Cleveland Show and new series Bordertown.
Family Guy has been a major part of the BBC Three schedule since 2006, becoming one of the channel's highest rating shows.
But it's not the last we'll see of the Griffins on the BBC as the corporation has one more new series to show - the one currently being broadcast in the States.
The BBC also still has rights to repeat episodes from previous series - for the moment.
The BBC says Family Guy will be on the BBC for "at least the next two years".
There's been discussion over what would happen to the offbeat comedy, given plans to move BBC Three online.
More than 270,000 people have signed a petition against the move.
The BBC said: "We are incredibly proud that the BBC has successfully aired Family Guy for the past nine years and built the series into such a hit in the UK.
"However, when a show becomes so successful it often becomes a target for other broadcasters.
"We are sorry that it will not have a long term home on the BBC."
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Ann Maguire, 61, was stabbed to death by a 15-year-old pupil at Corpus Christi Catholic College in Leeds in April.
Her attacker Will Cornick, now 16, was jailed for a minimum of 20 years at Leeds Crown Court in November.
The plaque is displayed at the pavilion at Wigan's Mesnes Park where Mrs Maguire sold ice creams as a teenager.
A rose was also planted in the park's memorial garden.
The plaque was unveiled on Friday by Mrs Maguire's sisters, Shelagh Connor and Denise Courtney.
Ms Courtney told BBC Radio Manchester it was "very, very important" to have a memorial in Wigan.
She said: "This was her hometown; she was here for 19 years of her life and she still has family and friends [here].
"She said she wanted somewhere this side of the Pennines for people to go to to remember her without having to travel to Leeds."
Ms Courtney added: "She was an extraordinary person; she touched so many people in so many different ways particularly the students she taught for 40 years."
She said the words on the plaque "capture the essence of Ann and the person she was".
They say: "Ann was one of life's beautiful, sunny and extraordinary people. May her goodness, kindness and generosity of spirit continue to be an inspiration to us all and may her memory never be forgotten."
A memorial service was held in Mrs McGuire's memory on Thursday, featuring a choir consisting of many of her former pupils.

In a statement, the Organisation for the Prohibition of Chemical weapons (OPCW) said the declaration was submitted three days ahead of schedule.
OPCW inspectors are also due to complete visiting the last four of 23 weapons sites declared by Syria.
The OPCW's mission was set up following outrage at a chemical weapons attack near the Syrian capital in August.
Sixty inspectors have been in Syria since 1 October. The OPCW, which is based in The Hague, said on Friday that its  team in Syria had visited 19 of the 23 sites disclosed by Syria.
Chemical stockpile
How to destroy chemical arsenal
Q&A: Disarmament deal
21 August attack: What we know
Under the UN resolution which set up the mission, Syria's chemical weapons production equipment must be destroyed by 1 November and stockpiles must be disposed of by mid-2014.
The organisation's work in Syria marks the first time the international chemical weapons watchdog - which won this year's Nobel Peace Prize - has been asked to oversee the destruction of a weapons armoury during a conflict.
More than 100,000 people have been killed in the fighting that has ravaged Syria for two-and-a-half years, according to the UN.
More than two million people have fled Syria and some 4.5 million have been forced from their homes within the country.
Casualty figures vary for the chemical weapons attack on the Ghouta agricultural belt around Syria's capital, Damascus, on 21 August.
It was estimated to have killed hundreds of people. The United States and other Western powers blamed the attack on President Bashar al-Assad's forces.
But Mr Assad accuses Syrian rebels of being behind it.
The Griffin family is moving home - to ITV2.
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A plaque dedicated to a murdered school teacher has been unveiled in her hometown in Greater Manchester.
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Syria has handed in a plan for the destruction of its chemical weapons to the watchdog monitoring the process.