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The 35-year-old has 184 goals in 252 matches in an international career spanning 15 years.
She was in the 2015 World Cup winning squad and won two Olympic golds.
"It's been an amazing, wonderful ride and I can't wait to see what the next chapter of my life brings," she said.
Wambach was the 2012 Fifa Women's World Player of the Year and is also a six-time US Soccer Female Athlete of the Year winner.
She will be with the US team for all four of its December matches, but her final game will come on 16 December against China in New Orleans as the last match of the 10-game tour.
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"Abby is a player who has transcended our sport and her legacy as one of the world's greatest players is set forever," said US head coach Jill Ellis.
"What she has done for women's soccer and women's sports overall with her amazing talents on the field and her personality off it has been inspiring to watch.
"I am just extremely happy that she could end her career with that elusive World Cup title and go out on top, right where she deserves to be."
In her career, Wambach scored just over 500 goals for her high school, college, professional club teams and the United States youth and senior international sides.

More than 5,300 bottles of alcohol were seized by the investigators in the southern city of Liuzhou.
They also found packets of a white powder called Sildenafil, better known as the anti-impotence drug Viagra.
Police in the Guangxi region are now investigating the two distillers.
The Liuzhou Food and Drug Administration said (in Chinese) that the powder was added to three different types of 'baijiu' - a strong, clear spirit that is the most popular drink in China.
They said the haul was worth up to 700,000 yuan (Â£72,000; $113,000).
Doctors recommend that adults requiring prescription should take only one dose of Viagra a day, with a lower dose for those over the age of 65.
China continues to face widespread food safety problems.
In June, police in cities across China seized more than 100,000 tonnes of smuggled meat, some of which was more than 40 years old.
The 2008 tainted milk scandal outraged the nation.
Some 300,000 people were affected and at least six babies died after consuming milk adulterated with melamine.

A long clearance from debutant goalkeeper Jonathan Mitchell eluded home defender Shaun Brisley and allowed Marriott to lob keeper Alex Cisak.
Brisley was later stretchered off and hospitalised with a head injury after receiving lengthy treatment when injured colliding with Mitchell.
Dan Potts went close to making it 2-0 after the break, but curled wide.
Leyton Orient manager Kevin Nolan told BBC Radio London:
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"The most disappointing thing for me is that we conceded a very sloppy goal.
"I must admit I was quite disappointed with the referee today but I don't want to go on about that because I'll end up getting in trouble.
"I thought today we were very good, we dominated the game and didn't really give them any chances. I don't think they offered a lot going forward but they defended fantastically well."
Luton boss Nathan Jones told BBC Three Counties Radio:
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"I'm massively proud in terms of what they gave me today, their endeavour, how they went about their work.
"They gave me absolutely everything today and that is all you can ask.
"There was one bit of quality in the game, Jack produced it and it won the game.
"I'm really proud of the players, I'm getting to know what they will produce. There is an equilibrium to their performances and I like that, I can work with that. It's a platform."
Women's football's all-time international leading goalscorer, United States striker Abby Wambach, will retire at the end of a World Cup victory tour in December.
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Distillers in China added Viagra to thousands of bottles of spirits and told customers it had "health-preserving qualities", food safety officials say.
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Jack Marriott scored the only goal of the game at Leyton Orient to extend Luton's winning run to four games.