The flight search engine website reported revenues of Â£120m for 2015, up 28% on the previous year.
The company saw gross bookings of $11.2bn, up 49% on 2014, with visitors to the website up 48%. On average, 50m people used the website each month.
Company founder and chief executive Gareth Williams said the company had seen "excellent growth".
He said: "2015 was another strong year for Skyscanner, showing solid progress in our strategy of expansion beyond our home market, into mobile and beyond flights.
"Our first-half focus on investing in our product drove momentum for the business in the second half. We also saw excellent growth in travellers planning their trips on Skyscanner all around the world, especially on mobile and in the important regions of Asia Pacific and the Americas."
The Edinburgh-based company saw a rise in the number of people using its mobile app, with 40m downloads and an increase of 24% in mobile bookings.
Particular growth was recorded in the Asia-Pacific region, while visits in China were up 67% after Skyscanner bought a Chinese search firm in 2014.
The company opened new offices in London and Sofia as well as expanding existing operations in Budapest and Miami, increasing its global staff to 770.

Gloucester have played away from their Meadow Park home since a flood in 2007.
In September, planning permission was approved to permit initial work on building a new ground for Gloucester.
The University of Gloucestershire-based All Golds, who are in the third tier of rugby league, currently play in Cheltenham but want a permanent home.
All Golds president Lionel Hurst told BBC Radio Gloucestershire: "We have met with those who own the club.
"We can see that it makes considerable sense. We will need to have more meetings.
"We are a long way from getting over the line on this, but watch this space. We are constantly seeking our own permanent base for the club.
"Rugby league and football are very good friends throughout the land. It would be a very significant partnership if it happened."

The group made a loss of $219m (Â£175.1m) compared with the same time last year when profits were $106m.
However, a growing demand for "accurate and timely journalism" was helping to lift subscriber numbers for some of its news outlets, it said.
News Corp gets more than half its revenue from outside the US.
The firm's chief executive Robert Thomson said The Wall Street Journal now had more than 2.1 million paid subscribers and that for the first time, more than 50% of those subscribers were digital.
"Audiences are craving integrity, which is why so many of our mastheads have reported strong growth in readers and subscribers this quarter," he said.
"And advertisers need a trusted canvas and real results, not the muddled, muddied metrics of many digital platforms."
The group reported strong performances at its book publisher Harper Collins and its digital estate agency division.
Rapid expansion meant "digital real estate" was "well on the way to becoming the largest contributor to our profitability", said Mr Thomson.
"This segment posted another very strong quarter, with a 16% year-over-year revenue increase, improved margins and robust audience gains," he added.
Mr Thomson said a reduction in the value of print-related fixed assets at the firm's Australian newspaper business had hurt income for the quarter, together with non-cash charges related to Foxtel.
News Corp's businesses include news and information services, book publishing, real estate services and cable network programming as well as pay-TV distribution in Australia.
Scottish-based travel firm Skyscanner has reported double-digit growth for the seventh consecutive year.
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National League North side Gloucester City are in talks with rugby league team Gloucestershire All Golds about a potential groundshare.
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Rupert Murdoch's News Corp has reported a loss for the three months to December, amid a difficult environment for print advertising.