A Â£100,000 reward is on offer for information leading to the conviction of the killers of 14-year-old Charlene Downes or the recovery of her body.
An appeal will be made on the big screen and inside programmes during the team's match against Brighton at Bloomfield Road on Saturday.
Charlene disappeared near Blackpool's North Pier on 1 November 2003.
Police believe she was one of a number of girls who were groomed for sex.
Lancashire Police and Crime Commissioner Clive Grunshaw said: "Someone out there knows something about what happened to Charlene.
"Detectives believe the answer lies in Blackpool - and it could lie at Bloomfield Road on Saturday."
Det Supt Andy Webster said: "We have never given up our search for information about Charlene, who we believe was murdered more than a decade ago.
"We appreciate that a considerable amount of time has passed since Charlene went missing, but we would still encourage anyone with information at all to come forward and speak to us."
In 2008, a judge ordered a man to be cleared of Charlene's murder, after "grave doubts" were raised around evidence during his second trial. The jury in his first trial failed to reach a verdict.
The following year, the Independent Police Complaints Commission (IPCC) said police errors in gathering evidence had contributed to the collapse of the retrial.
The IPCC investigation concluded the investigating team was guilty of a strategic and tactical failure in the management of the material and several officers were disciplined, with one being forced to resign in 2011.
The resignation order was overturned by a Police Arbitration Tribunal in 2012.

Lee Gaskell grabbed the game's first try after 22 minutes, with Danny Brough adding the extras and a later penalty to make it 8-0 at half-time.
Ukuma Ta'ai's touchdown for the hosts was followed by Gaskell's second as Huddersfield built a 20-point lead.
Josh Drinkwater got Leigh's only try before Leroy Cudjoe completed the win.
Huddersfield's triumph, their second in as many weeks over the competition's bottom two sides, confirms the make up of the Super 8s and Qualifiers.
Warrington, who won the League Leaders' Shield last season and lost both major finals in 2016, are resigned to having to battle to avoid relegation.
Leigh, whose captain Micky Higham made his 500th career appearance in the defeat, need to beat near neighbours Salford next week and hope that Widnes fail to overcome Warrington if they are to avoid finishing bottom after 23 Super League games.
Huddersfield Giants boss Rick Stone:
"It was a tough, physical game and we showed some good resilience.
"Our goal is now to win as many games as we can and we have a few boys to come back from injury."
On confirming a top eight finish: "I was always confident as most of the time we were a bit banged up with injuries and I felt once we got those players back it would help us.
"It started probably at the Magic Weekend with a bit of a rusty win over Catalans. We began to respect the process a bit more - the boys have bought into that and the last couple of months have been good."
Leigh Centurions coach Neil Jukes:
"I thought we turned up for one another and had a real dig, but there were just too many silly scenarios which kept putting unforced pressure on ourselves.
"While the scoreline doesn't look great, to do the amount of defending we did shows that there's still a good work ethic within them. But regarding smartness we probably get one out of 10."
Huddersfield Giants: Rankin; McGillvary, Cudjoe, S Wood, McIntosh; Gaskell, Brough; Rapira, Leeming, Ikahihifo, Roberts, Ferguson, Hinchcliffe.
Replacements: O'Brien, Wakeman, Clough, Ta'ai.
Leigh Centurions: Brown; Higson, Crooks, Langi, Dawson; Mortimer, Drinkwater; Hock, Higham, Hansen, Paterson, Vea, Stewart.
Replacements: Pelissier, Tickle, Hopkins, Burr.
Referee: Scott Mikalauskas
Blackpool football fans are being asked to help solve the murder of a teenager who disappeared over a decade ago.
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Huddersfield Giants confirmed their Super League status for another season with a comfortable win over bottom side Leigh Centurions.