Rory Gallagher's side have recovered from the disappointment of their heavy Ulster semi-final defeat to Tyrone with narrow wins over Longford and Meath.
Galway enter into Round 4A of the qualifier series after surrendering their Connacht title to Roscommon.
Cian Mulligan is the only injury concern for Donegal with a quad strain.
Following their nine point loss to Tyrone in the Ulster championship, Donegal returned to winning ways with a hard-fought victory over Longford and then came out on top of a thrilling shoot-out against Meath earlier this month.
2012 Footballer of the Year Karl Lacey will equal Christy Toye's record of 65 championship appearances for Donegal if he features on Saturday.
Galway had a strong start to their season when they beat Kildare to finish top of Division Two of the National League and earned promotion to Division One for next season.
Kevin McStay's side beat arch-rivals Mayo in their Connacht championship semi-final but they will be disappointed with the way they lost their provincial title after a heavy nine-point loss to Roscommon in the Connacht final.

Councils in England are being allowed to raise the tax by 6% over two years to plug a care funding gap.
But Wales' Social Services Minister Rebecca Evans told BBC Wales that increasing the tax was not "fair" and "not an approach we're taking".
The Welsh Local Government Association has warned councils face a Â£92m social care "black hole" in 2017-18.
Leading experts say the cost of providing care could double to Â£2.3bn by 2030.
Speaking on The Wales Report on Wednesday, Ms Evans said: "Some parts of Wales have a much larger proportion of older people than others.
"And obviously if we were to put the burden on local authorities to raise council tax to pay for that, it would disproportionately affect some parts of Wales more than others."
Ms Evans said Welsh ministers wanted to take a longer term approach towards social care but "we do need the UK government to help us with this".
"We don't know what our long-term funding is going to be from the UK government," she said.
"So these are issues that are beyond our control, but within our control we're certainly doing everything we can to make social care good quality and fair across Wales in terms of paying for care as well."
"I'm under no illusion how fragile the sector is in Wales, and the fact that Welsh Government does need to support it," she added.
Mario Kreft, chair of Care Forum Wales which represents independent care providers, said that in a "relatively mild winter we're seeing huge pressures" in Wales and across the UK.
"This should be no surprise to anybody," he said.
"The reality is that we are a million miles away from where we need to be, where we could've been, and we need a wake up call."
The Wales Report is on BBC One Wales at 22:40 GMT on Wednesday 8 February.
Donegal are hoping the momentum they have gained through the qualifier series can carry them through to the All Ireland quarter-finals.
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Spiralling social care costs cannot be met by increasing council taxes in Wales, ministers have ruled.