<unk>  <unk> T) is a mature T-cell lymphoma characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs). It is also known as immunoblastic lymphadenopathy (Lukes-Collins Classification) and<unk> -type (lymphogranulomatosis X) T-cell lymphoma (Kiel Classification). Clonal T-cell receptor and immunoglobulin gene rearrangements are involved in the pathogenesis of<unk> . On gross pathology, aborization and proliferation of high endothelial venules are characteristic findings of<unk> .  On microscopic histopathological analysis, CD4+ T-cells, CD8+ T-cells, and polyclonal plasma cells are characteristic findings of<unk> . There are no established causes for<unk> .<unk>  must be differentiated from other diseases such as peripheral T-cell lymphoma-not otherwise specified, classical Hodgkin's lymphoma, diffuse large B cell lymphoma, and nodal marginal zone lymphoma.<unk>  commonly affects middle-aged or elderly individuals.<unk>  affects men and women equally. There are no established risk factors for<unk> . According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for<unk> . Common complications of<unk>  include rheumatoid arthritis, autoimmune hemolytic anemia, vasculitis, and autoimmune thyroid disease. According to the Lugano classification, there are four stages of<unk>  based on the number of nodes and extranodal involvement. The most common symptoms of<unk>  include fever, weight loss, skin rash, night sweats,  edema, chest pain, abdominal pain, bone pain, fatigue, dark urine, shortness of breath, chronic pain, swelling of joints, and painless swelling of the neck, axilla, groin, thorax, and abdomen. Common physical examination findings of<unk>  include fever, rash, ulcer, splenomegaly, hepatomegaly, pleural effusion, ascites, chest tenderness, abdomen tenderness, bone tenderness, arthritis, peripheral lymphadenopathy, and central lymphadenopathy. Laboratory tests for<unk>  include complete blood count (CBC), polyclonal hypergammaglobulinemia, FISH, blood chemistry studies, flow cytometry, immunohistochemistry, and immunophenotyping. Abdominal CT scan may be helpful in the diagnosis of<unk> . Findings on CT scan suggestive of<unk>  include mediastinal lymphadenopathy, inguinal lymphadenopathy, aortal lymphadenopathy, and bilaterally enlarged kidneys. MRI may be helpful in the diagnosis of<unk> . Lymph node or extranodal tissue biopsy is diagnostic of<unk> . Abdominal ultrasound may be helpful in the diagnosis of<unk> . Findings on ultrasound of the abdomen suggestive of<unk>  include hepatomegaly and splenomegaly. Positron emission tomographic scan may be helpful in the diagnosis of<unk> . Findings on positron emission tomographic scan suggestive of<unk>  include lymphadenopathy and bilaterally enlarged kidneys. Other diagnostic studies for<unk>  include laparoscopy, laparotomy, bone marrow aspiration, and bone marrow biopsy. The predominant therapy for<unk>  is chemotherapy. Adjunctive stem cell transplantation may be required in certain cases.
Angioimmunoblastic T-cell lymphoma
Peripheral T cell lymphoma
Blastic NK cell lymphoma
Extranodal NK-T-cell lymphoma
Anaplastic large cell lymphoma
Nodal marginal zone lymphoma
Mantle cell lymphoma
Primary mediastinal large B-cell lymphoma