<unk> -2 selective inhibitor is a form of Non-steroidal anti-inflammatory drug (NSAID) that directly targets<unk> -2, an enzyme responsible for inflammation and pain. Selectivity for<unk> -2 reduces the risk of peptic ulceration, and is the main feature of celecoxib, rofecoxib and other members of this drug class.<unk> -2-selectivity does not seem to affect other adverse-effects of NSAIDs (most notably an increased risk of renal failure), and some results have aroused the suspicion that there might be an increase in the risk for heart attack, thrombosis and stroke by a relative increase in thromboxane. Rofecoxib (commonly known as Vioxx) was taken off the market in<unk> 004 because of these concerns.
COX-2 inhibitor
Antagonist 
Histone deacetylase inhibitor
Protein kinase inhibitor
TNF inhibitor
Phosphodiesterase inhibitors
Proteasome inhibitor
Renin inhibitor