A<unk>  (or<unk>  is an especially toughened area of skin which has become relatively thick and hard as a response to repeated contact or pressure.  In botany, the term is also used to announce a condition of thickened surfaces of leaves or other plant parts.  Since repeated contact is required,<unk> es are most often found on hands or feet.<unk> es are generally not harmful, but may sometimes lead to other problems, such as infection. Shoes that fit tightly can often produce<unk> es on the feet. String instrument players develop<unk> es where their fingers make contact with the strings, but these<unk> es are often desirable as they help alleviate the pain from the tension of the strings and make playing easier. Dancers often develop<unk> es on the soles of their feet from dancing barefoot, which makes performing turns less difficult. Video game players may develop<unk> es on their thumbs, especially if using a controller with a poor D-pad. Frequent use of a writing implement may lead to a<unk>  on the middle finger, commonly known as a "writer's bump".
Callus
Sex organ
Scrotum
Ovary
Pus
Papaveretum
Gonad
Hymen