<unk>  is a macrolide glycopeptide antibiotic.<unk>  (Dynabac) is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-(2-methoxyethoxy)acetaldehyde. The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine. Erythromycyclamine is a semisynthetic derivative of erythromycin in which the 9-ketogroup of the erythronolide ring has been converted to an amino group. Erythromycyclamine retains the antibacterial properties of erythromycin oral administration. The prodrug,<unk> , is provided as enteric coated tablets to protect it from acid catalyzed hydrolysis in the stomach.
Orally administered<unk>  is absorbed rapidly into the plasma, largely from the small intestine. Spontaneous hydrolysis to erythromycyclamine occurs in the plasma. Oral bioavailability is estimated to be about 10%, but food does not affect absorption of the prodrug.
Dirithromycin
Azithromycin 
Telithromycin
Roxithromycin
Difloxacin
Moxifloxacin 
Levofloxacin 
Nadifloxacin