<unk>  was described by Cockbill, Burmester, and Heptinstall (1988) who reported a 25-year-old woman with a history of mild bruising and bleeding. Bleeding time, activated partial thromboplastin time, prothrombin time, and euglobulin lysis time were within normal limits. There were no<unk>  antibodies detected. The patient's mother and two sisters had histories of easy bruising and heavy menstrual periods. A brother had no reported bleeding tendencies.<unk> s from the mother, sisters, and a daughter were normal in number and appearance under the light microscope.<unk> s in blood collected into EDTA tubes appeared<unk>  and agranular compared with<unk> s from blood in citrate or heparin. The key finding is under electron microscopy, EDTA-exposed<unk> s showed extensive activation, with loss of storage granule contents and<unk> pod formation.<unk>  aggregation studies were normal.
The abnormal<unk>  reaction following EDTA exposure is thought to be caused by a plasma factor, although not an immunoglobulin. The mechanism by which<unk>  activation occurs remains unknown. Few cases have been reported in the literature.<unk>  differs from<unk><unk>  syndrome (GPS), one of the giant<unk>  syndromes. GPS is characterized by thrombocytopenia, abnormally large agranular<unk> s in peripheral blood smears, and almost total absence of<unk>  alpha-granules and their constituents. The defect in GPS is the failure of megakaryocytes to package secretory proteins into alpha-granules. Patients with the GPS are affected by mild to moderate bleeding tendencies.
Pseudo gray platelet syndrome
Sticky platelet syndrome
Grey platelet syndrome
Giant platelet disorder
Glanzmann's thrombasthenia
Heparin-induced thrombocytopenia
Von Willebrand disease
Familial dysfibrinogenemia