The diagnostic criteria of Kasukawa include symptoms common to all the<unk> s involved, presence of antibodies against the U1snRNP, and selected symptoms typical of each of the particular component<unk> s separately (systemic lupus erythematosus, systemic sclerosis, polymyositis). The diagnosis of MCTD can be confirmed by at least one common symptom, positive antibodies against U1RNP, and at least one symptom from each of the component<unk> s.
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