The<unk>  takes part in the regulation of cellular responses to cytokines and growth factors. Employing Janus kinases <unk> s) and Signal Transducers and Activators of Transcription <unk> s), the<unk>  transduces the signal carried by these extracellular polypeptides to the cell nucleus, where activated<unk>  proteins modify gene expression. Although<unk> s were originally discovered as targets of Janus kinases, it has now become apparent that certain stimuli can activate them independent of<unk> s. The<unk>  plays a central role in principal cell fate decisions, regulating the processes of cell proliferation, differentiation and apoptosis. It is particularly important in hematopoiesis - production of blood cells.
JAK-STAT signaling pathway
Wnt signaling pathway
Mitogen-activated protein kinase
Unfolded protein response
MAP kinase kinase kinase
Rho family of GTPases
Receptor tyrosine kinase
Rho GTPase