<unk>  <unk>  is a cancer of the<unk>  line of white blood cells characterized by the rapid proliferation of abnormal cells, which accumulate in the bone marrow and interfere with the production of normal blood cells. This leukemia arises from myeloblasts, which are hematologic white cells that are normally involved in hematopoiesis.<unk>  may be classified according to the French-American-British (FAB) classification and World Health Organization (WHO).<unk>  must be differentiated from other diseases such as: acute lymphoblastic leukemia, chronic<unk>  leukemia, agranulocytosis, aplastic anemia and lymphoma. In 2015, the incidence of<unk>  was approximately 6.5 per 100,000 individuals with a case-fatality rate of approximately 50% in the United States. The incidence of<unk>  increases with age. Common risk factors in the development of<unk>  are<unk> ysplastic syndromes, aplastic anemia, myelofibrosis and paroxysmal nocturnal hemoglobinuria. Common complications include infections, disseminated intravascular coagulation, and hemorrhage. Symptoms of<unk>  include fever, fatigue, weight loss and loss of appetite. Physical examination findings of<unk>  include anemia, fever, pallor, Leukemia cutis, bruising, petechiae, ecchymosis and tachycardia. Laboratory findings consistent with the diagnosis of<unk>  include leukocytosis, thrombocytopenia, anemia and leucopenia. If a lung infection is suspected, a chest x-ray may be helpful in the diagnosis. The mainstay therapy is chemotherapy and usually includes a combination of daunorubicin, cytarabine and etoposide or mitoxantrone and anabolic steroids. Supportive care includes intravenous nutrition, antimicrobial therapy, and replacement of blood products.
Acute myeloid leukemia
Myeloid leukemia
Lymphoid leukemia
Prolymphocytic leukemia
Acute monocytic leukemia
Acute lymphoblastic leukemia
Acute myeloblastic leukemia
Leukemoid reaction