<unk>  puberty is the result of disturbances in hypothalamus-pituitary-gonadal (HPG) axis. Genetics plays an important role in the development of<unk>  puberty. In case of constitutional delay of growth and puberty (CDGP),  50-75% of patients have a positive family history of<unk>  puberty. About 25 various genes, in 3 different group of Kallmann syndrome-related genes, hypothalamus-pituitary-gonadal (HPG) axis related genes, and obesity-related genes play roles in<unk>  puberty. On gross pathology, lack of testicular enlargement in boys or breast development in girls is the characteristic finding of<unk>  puberty. Microscopic evaluation of ovaries in a patient with<unk>  puberty may reveal the presence of normal cuboidal epithelium; the ovary has some dense fibrous tissue, about 0.4 mm thick band, in the cortex. The band is extended under the tunica albuginea, devoid of follicles. Under the fibrous band, there will be numerous small follicles. These follicles consist of primordial (51%), intermediary (42%), and primary (7%) follicles.
Delayed puberty pathophysiology
Androgen insensitivity syndrome risk factors
Hypopituitarism pathophysiology
Polycystic ovary syndrome pathophysiology
Androgen insensitivity syndrome pathophysiology
Delayed puberty causes
Prolactinoma risk factors
Hypogonadism risk factors