The pathogenesis of<unk> 's arteritis is poorly understood.<unk> 's arteritis characterized by segmental and patchy granulomatous inflammation of the aorta and its major derivative branches.This inflammation leads to arterial stenosis, thrombosis, and aneurysms. Three factors that have been suggested to have association with susceptibility, development and progression of<unk> 's arteritis are genetic inﬂuences, immunologic mechanisms, and relationship to tuberculosis. The most important conditions associated with<unk> 's arteritis include ankylosing spondylitis, inflammatory bowel disease, and Behçet's syndrome. On gross pathology, stiff and rigid aorta on palpation, gelatinous appearance of thickened adventitia, and sharp line of demarcation between normal and diseased segments might be seen. On microscopic histopathological analysis characteristic findings of<unk> 's arteritis include inflammation around the vasa vasorum and at the medio-adventitial junction, edema of the media and adventitia, giant cell granulomatous reaction, laminar necrosis, and fragmentation of elastic fibers.
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