Leukoplakia and erythroplakia have the greatest potential for malignant transformation in tongue cancer. World Health Organization classified oral cancer into  mild, moderate, and severe dysplasia. Genes involved in the pathogenesis of tongue cancer include TP53, c-myc, and erb-b1. On gross pathology, exophytic, ulcerative, and infiltarative growth patterns are characteristic findings of tongue cancer. Tongue cancer constitutes of highly differentiated squamous cells lacking frank cytologic criteria of malignancy with rare mitoses. The surface of the lesion is covered with compressed invaginating folds of keratin layers. A stroma-like inflammatory reaction and a blunt pushing margin may be seen.
Tongue cancer pathophysiology
Oral cancer pathophysiology
Salivary gland tumor pathophysiology
Tongue cancer risk factors
Laryngeal cancer pathophysiology
Tongue cancer differential diagnosis
Desmoid tumor pathophysiology
Epiglottitis pathophysiology