A<unk>  is one that affects a number of organs and tissues, or affects the body as a whole  Although most medical conditions will eventually involve multiple organs in advanced stage (i.e. Multiple organ dysfunction syndrome), diseases where  multiple organ involvement is at presentation or in early stage are considered above.
Systemic disease
Neuromuscular disease
Central nervous system infection
Congenital abnormality
Central nervous system disease
Brain damage
Genetic disorder
Neurodegenerative disease