Autoimmune polyendocrine<unk>  (APS) is a group of autoimmune disorders against multiple (poly) endocrine organs, although non-endocrine organs may be affected. Autoimmune polyendocrine<unk>  is also known as polyglandular autoimmune<unk>  and polyendocrine autoimmune<unk> . In autoimmune polyendocrine<unk>  there is loss of self tolerance or defective T cell regulation and the immune system attacks various endocrine and non-endocrine organs throughout the body. APS is seen in genetically susceptible individuals who when exposed to certain environmental triggers (such as infection) leads to autoimmunity. The involvement of endocrine glands can be simultaneous or sequential. The autoimmune reaction can either be humoral or cell mediated which may lead to partial or complete destruction of the tissue involved. The common endocrine glands involved are parathyroids, adrenals, thyroid, and pancreas. However any other non endocrine gland/tissue of the body may be involved.
Autoimmune polyendocrine syndrome pathophysiology
Graves' disease pathophysiology
Hashimoto's thyroiditis pathophysiology
Acromegaly pathophysiology
Autoimmune polyendocrine syndrome epidemiology and demographics
Silent thyroiditis pathophysiology
Cushing's syndrome pathophysiology
Sezary syndrome pathophysiology