Enchondromas arise from rests of growth plate cartilage or chondrocytes that are normally involved in the production and maintenance of the cartilaginous matrix, which consists mainly of collagen and proteoglycans. Genes involved in the pathogenesis of enchondromas and periosteal<unk> s include isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) . On gross pathology, small (usually less than 3 cm), translucent, grey blue, nodular lesions with occasional calcifications are characteristic findings of<unk> s. Enchondromas may be single or multiple. Multiple enchondromas are associated Maffucci syndrome, Ollier disease and metachondromatosis.
Chondroma pathophysiology
Liposarcoma pathophysiology
Lipoma pathophysiology
Hemangioma pathophysiology
Neurofibroma pathophysiology
Fibroma pathophysiology
Lymphangioma pathophysiology
Ganglioneuroma pathophysiology