In the general population, 0.6% to 2.5% of patients will develop a hypersensitivity reaction to<unk>  and that number is increased to 4.3% to 11.0% among patients with asthma. Dual antiplatelet therapy with both<unk>  and clopidogrel has been associated with improved clinical outcomes in the management of patients with acute coronary syndromes. Although there is a lack of supporting data, patients with<unk>  hypersensitivity are sometimes managed with clopidogrel monotherapy. Indeed,<unk>  hypersensitivity has been associated with stent thrombosis in some case reports.<unk>  is required when continued<unk>  administration is essential (e.g. management of an acute coronary syndrome with stent placement). A rapid protocol can be used as described below. While this protocol can be implemented over the course of several hours, it is not applicable to those patients who must proceed to the cardiac catheterization laboratory such as the patient with ST segment elevation myocardial infarction where "time is muscle".
Aspirin desensitization
Clopidogrel resistance
Coronary vasospasm
Warfarin over anticoagulation
Cascade reaction
Defibrination syndrome
Post-thrombotic syndrome
Reversible cerebral vasoconstriction syndrome