<unk>  (<unk>  was first discovered by Samuel Rosen, Benjamin Castleman, and Averill Liebow, in 1958.<unk>  (<unk>  may be classified into 2 subtypes, primary and secondary<unk> . The pathogenesis of<unk>  is characterized by the intraalveolar accumulation of surfactant phospholipid and apoproteins.<unk>  develop because of reduced granulocyte-macrophage colony-stimulating factor (GM-CSF) levels or function and/or impaired alveolar macrophage function. On gross pathology after lung washings, fluid with the milky composition are the characteristic finding of<unk> . On microscopic histopathological analysis, terminal bronchioles and alveoli are filled with a lipoproteinaceous material that will be pink after periodic acid-Schiff (PAS) stain. The exact etiology of<unk>  <unk>  is unknown, but it may be associated with exposure to insecticides, hematologic malignancies, or HIV infection.<unk>  must be differentiated from other diseases that cause ground glass opacities in radiography.<unk>  is more commonly observed among patients aged 40- 50 years old. Men are more commonly affected with<unk>  than women. Common risk factors in the development of<unk>  are current or former cigarette smokers and HIV infection. If left untreated, patients with<unk>  may progress to develop<unk>  fibrosis, cor pulmonale. Symptoms of<unk>  may include dyspnea on exertion, cough. The physical examination is often normal. Laboratory findings are serum anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in autoimmune<unk>  and elevated serum level of GM-CSF in hereditary<unk> . Imaging studies include chest x-ray and high resolution computed tomography (HRCT). Treatment include whole-lung lavage (WLL), recombinant GM-CSF and lung transplantation.
Pulmonary alveolar proteinosis
Eosinophilic pneumonia
Cavitary pneumonia
Chemical pneumonitis
Viral pneumonia
Atypical pneumonia
Alveolar lung disease
Idiopathic interstitial pneumonia