The<unk>  is a<unk>  reaction taking place between a thioester and an organozinc halide in the presence of a palladium catalyst. The reaction product is a ketone. This reaction was discovered by Tohru<unk>  et al. in 1998 . Advantages are high chemoselectivity, mild reaction conditions and the use of less-toxic reagents .
One advantage of this method is that the reaction stops at the ketone and does not proceed to a tertiary alcohol. In addition, the protocol is compatible with functional groups such as ketones, acetates, sulfides, aromatic bromides, chlorides and aldehydes.
The reaction (interrupted) has been used in the synthesis of biotin
Fukuyama coupling
Kumada coupling
Sensory decussation
Robinson oscillator
Prepulse inhibition
Autoregulation
Accessory pathway
Dielectric relaxation