<unk>  <unk>  is a type of myeloproliferative disorder characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow.<unk>  is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.<unk>  may be classified into 3 categories: primary, secondary, and idiopathic.<unk>  may be caused by either stem cell, myeloid, or eosinophilic neoplasms.<unk>  is mainly caused by mutations in the BCR-ABL, PDGFRA, PDGFRβ, and KIT genes. There are some associations with chronic eosinophilic leukemia  as it shows similar characteristics and genetic defects. Patients with<unk>  may be initially asymptomatic.  Early clinical features include fatigue, diarrhea, and rash. Prognosis is generally poor, and the 3-year survival rate of patients with<unk>  is approximately 12%. Findings related with poor prognosis in<unk> , include: presence of anemia, thrombocytopenia, white blood cell count greater than 100,000 cells/cm3, abnormal marrow and/or basophils, elevated serum levels of vitamin B12, serum tryptase, and abnormal levels of leukocyte alkaline phosphatase. If left untreated,<unk>  is progressively fatal. Treatment will depend on the presence of mutations. Treatment of choice for patients with FIP1L1/PDGFRA mutation is imatinib and first line treatment for patients without FIP1L1/PDGFRA mutation is glucocorticoid therapy. The addition of the monoclonal antibody mepolizumab may reduce the dose of glucocorticoids. Once diagnosed and successfully treated, patients with<unk>  are followed-up periodically every 6 or 12 months depending on the clinical progression.  Follow-up testing includes the following tests: complete blood count, biochemical profile (liver enzymes, creatine kinase, renal function, and troponin),  electrocardiogram, and tissue biopsies.
Hypereosinophilic syndrome
Familial Eosinophilic Cellulitis
Wegeners granulomatosis
Churg-Strauss syndrome
DRESS syndrome
Mixed connective tissue disease
IMAGE syndrome
MOMO syndrome