<unk>  <unk>  is defined as the fluid portion of one unit of human blood that has been centrifuged, separated, and<unk>  solid at -18° C (or colder) within 6 hours of collection. Other single-donor<unk>  units, either<unk>  or liquid, may be substituted for<unk> . Indications for these products are interchangeable with those for<unk>  except for coagulation factor V deficiency. For that reason, the term<unk>  in this article otherwise applies to all single-donor<unk>  units.
The use of<unk>  and its products has evolved over a period of four decades. The use of<unk>  has increased tenfold within the past 10 years and reached almost 2 million units annually in the United States. This trend may be attributable to multiple factors, possibly including decreased availability of whole blood due to widespread acceptance of the concept of component therapy.<unk>  contains the labile as well as the stable components of the coagulation, fibrinolytic and complement systems; the proteins that maintain oncotic pressure and modulate immunity; and other proteins that have diverse activities. In addition, fats, carbohydrates and minerals are present in concentrations similar to those in circulation. Although well-defined indications exist for the use of<unk>  in single or multiple coagulation deficiencies, indications for many of its other uses may be empiric.
Fresh frozen plasma
Cryoprecipitate
Cadaveric blood
Platelet rich plasma
Pentoxyverine
Caroverine
Protamine Sulfate
Elosulfase alfa