<unk><unk><unk>  arises from pre-follicular, center B cells, that are normally involved in the process of human immunoglobulin production. Development of<unk><unk><unk>  is the result of multiple genetic mutations that promote both malignant<unk>  proliferation and apoptotic resistance of mature B cells. Structural genetic mutations involved in the pathogenesis of<unk><unk><unk>  include chromosome 13q deletion, chromosome 17p deletion, and chromosome 11q deletion. On microscopic histopathological analysis, characteristic findings of<unk><unk><unk>  include small lymphoid cells, thin cytoplasmic border, lack of nucleolus, and the presence of smudge cells.
Chronic lymphocytic leukemia pathophysiology
Hairy cell leukemia pathophysiology
Chronic myelogenous leukemia pathophysiology
Chronic neutrophilic leukemia pathophysiology
Non-Hodgkin lymphoma pathophysiology
Mast cell leukemia pathophysiology
B-cell lymphoma pathophysiology
T-cell prolymphocytic leukemia pathophysiology