Worldwide, the prevalence of<unk><unk><unk>  is 60 per 100,000 persons. In North America, South America, Europe, and Asia, the incidence of<unk><unk><unk>  ranges from as low as 1 per 100,000 persons to as high as 20 per 100,000 persons, with an average prevalence of 12 per 100,000 persons. The overall mortality rate of<unk>  is very high, estimated at approximately 50,000 deaths per 100,000. Women are more commonly affected with<unk><unk><unk>  than men.<unk><unk><unk>  flare-ups are more prevalent in women.<unk><unk><unk>  is more prevalent in people of the African and Asian races.
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