<unk>  ([bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane) is an active pharmaceutical ingredient (API) with antimicrobial and anti-lipopolysaccharide properties. Derived from the amino acid taurine, its immuno modulatory action is reported to be mediated with priming and activation of macrophages and polymorphonuclear leukocytes.<unk>  has been used to treat patients with peritonitis and as an antiendoxic agent in patients with systemic inflammatory response syndrome. It is a live-saving antimicrobial for severe abdominal sepsis and peritonitis.
For severe surgical infections and use in surgical oncology<unk>  is active against a wide range of micro- organisms that include gram positive bacteria, gram negative bacteria, fungi, mycobateria and also bacteria that are resistant to various antibiotics such as MRSA, VISA VRSA ORSA VRE. Additionally,<unk>  demonstrates some anti-tumor properties, with positive results seen in early-stage clinical investigations using the drug to treat gastrointestinal malignancies and tumors of the central nervous system.<unk>  is the active ingredient of anti-microbial catheter lock solutions for the prevention and treatment of catheter related blood stream infections (CRBSIs) and is suitable for use in all catheter based vascular access devices.
Bacterial resistance against<unk>  has never been observed in various studies.<unk>  acts by a non selective chemical reaction.
In aqueous solution, the parent molecule<unk>  forms equilibrium with taurultam and N-hydroxymethyl taurultam, with taurinamide being a downstream derivative.
The active principle of<unk>  are N-methylol derivatives of taurultam and taurinamide, which react with the bacterial cell wall, cell membrane, proteins as well as with the primary amino groups of endo- and exotoxins. Microbes are killed and the resulting toxins are inactivated; the destruction time in vitro is 30 minutes.
Pro-inflammatory cytokines and enhanced TNF-α levels are reduced when used as a catheter lock solution.<unk>  decreases the adherence of bacteria and fungi to host cells by destructing the fimbriae and flagella and thus prevent the biofilm formation.
Dose of 5g over 2 hours every 4 hours for at least 48 hours were given intravenously for the treatment of various sepsis condition.
Taurolidine
Tubocurarine
Dimethyltubocurarine
Aniline
Perhexiline
Perazine
Benperidol
Droperidol