<unk> (rectal) is a antiemetic that is FDA approved for the treatment of severe nausea and vomiting. There is a Black Box Warning for this drug as shown here.  Common adverse reactions include drowsiness, dizziness, hypotension..
Prochlorperazine 
Simethicone
Mersalyl acid
Ethacizine
Misoprostol
Magnesium oxide
Salicylic acid
Ioxaglic acid