The development of<unk>  adenomatous polyposis is the result of multiple genetic mutations. Genes involved in the pathogenesis of<unk>  adenomatous polyposis include APC and MUTYH genes. Many patients with<unk>  adenomatous polyposis have a positive family history of colorectal cancer or polyps. However, some of the patients with<unk>  adenomatous polyposis may have no previous family history. Loss of APC gene function is believed to be the first event in pathogenesis of colon cancer leading to formation of an adenoma. Three hundred mutations of APC gene have been discovered for<unk>  adenomatous polyposis. These mutations have premature stop codons and lead to a truncated protein.<unk>  adenomatous polyposis has autosomal dominant inheritance pattern if it results from mutations in the APC gene and autosomal recessive inheritance pattern if it results from mutations in the MUTYH gene. APC gene mutation is found in 6% of Ashkenazi Jews.<unk>  adenomatous polyposis is associated with different malignancies including stomach cancer, periampullary cancer, pancreatic cancer, hepatoblastoma, bile duct cancer, papillary thyroid cancer, and medulloblastoma. Duodenal adenoma, adrenal masses, desmoid tumor, osteomas, congenital hypertrophy of the retinal pigment epithelium, epidermoid cysts, and fibromas are associated with<unk>  adenomatous polyposis. On gross pathology, numerous polyps are characteristic finding of<unk>  adenomatous polyposis.
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