<unk>  is a metabolic pathway that uses energy released by the oxidation of nutrients to produce adenosine triphosphate (ATP). Although the many forms of life on earth use a range of different nutrients, almost all carry out<unk>  to produce ATP, the molecule that supplies energy to metabolism. This pathway is probably so pervasive because it is a highly efficient way of storing energy, compared to alternative fermentation processes such as glycolysis.
During<unk> , electrons are transferred from electron donors to electron acceptors such as oxygen, in a redox reaction. These redox reactions release energy, which is used to form ATP. In eukaryotes these redox reactions are carried out by a series of protein complexes within mitochondria, whereas in prokaryotes, these proteins are located in the cells' inner membranes. These linked sets of enzymes are called electron transport chains. In eukaryotes, five main protein complexes are involved, whereas in prokaryotes many different enzymes are present, using a variety of electron donors and acceptors.
The energy released as electrons flow through this electron transport chain is used to transport protons across the inner mitochondrial membrane, in a process called chemiosmosis. This generates potential energy in the form of a pH gradient and an electrical potential across this membrane. This store of energy is tapped by allowing protons to flow back across the membrane and down this gradient, through a large enzyme called ATP synthase. This enzyme uses this energy to generate ATP from adenosine diphosphate (ADP), in a phosphorylation reaction. Unusually, the ATP synthase works by the proton flow driving the rotation of part of the enzyme—it is a rotary mechanical motor.
Although<unk>  is a vital part of metabolism, it produces reactive oxygen species such as superoxide and hydrogen peroxide that lead to propagation of free radicals, damaging cells and contributing to ageing and disease. The enzymes carrying out this metabolic pathway are also the target of many drugs and poisons that inhibit their activities.
Oxidative phosphorylation
Cellular respiration
Pyruvate decarboxylation
ATP hydrolysis
Beta oxidation
Chiral pool synthesis
Glycolysis
Phosphorylation cascade