The incidence of<unk>  is approximately 1.2 per 100,000 individuals per year worldwide. The prevalence of AL<unk>  increased significantly between 2007 and 2015, from 1.6  per 100,000 in 2007 to 4.0 per 100,000 in 2015. The mortality rate of systemic<unk>  is approximately 100 per 100,000 deaths in developed countries. In<unk> , the mean age of presentation is 55 - 60 years. Men are more commonly affected by<unk>  than women.
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