The somatotroph cells of the anterior pituitary organ produce growth hormone (GH). The most widely studied impact of growth hormone is increasing weight. GH causes epiphyseal plate broadening and ligament development. GH deficiency results in alterations in the physiology of different systems of the body, manifesting as altered lipid metabolism, increased subcutaneous visceral fat, decreased muscle mass, decreased bone density, low exercise performance, and reduced quality of life. The hereditary premise of inborn growth hormone deficiency relies upon numerous factors; POU1F1 quality transformations are the most widely recognized hereditary reason for the joined pituitary hormone lack. Quality deletions, frameshift transformations, and jabber changes of GH1 quality have been described as reasons for familial GHD.
Growth hormone deficiency pathophysiology
Growth hormone deficiency causes
Growth hormone deficiency risk factors
Delayed puberty pathophysiology
Lipoid congenital adrenal hyperplasia pathophysiology
Hypopituitarism pathophysiology
Androgen insensitivity syndrome pathophysiology
Acromegaly pathophysiology