<unk>  may occur very rarely, and can cause a severe bleeding tendency. Incidence is 1 in a million to 1 in 5 million people. Most are due to mutations in the A subunit. Administration of recombinant A subunit improves clot stability and may become a therapeutic option for patients with this condition.
Factor XIII deficiency
Protein C deficiency
Factor V Leiden
Antithrombin III deficiency
Protein S deficiency
Factor I Deficiency
Activated protein C resistance
Hemophilia C