<unk>  <unk>  is the presence of coagulation abnormality (INR ≥1.5) and any degree of alteration in mental status in the absence of pre exisiting cirrhosis and any illness of <26 weeks duration.  Few exceptions that are included in spite of their presentation with cirrhosis are Wilson disease, vertically-acquired HBV, and autoimmune hepatitis if they have been recognized for <26 weeks.  While acetaminophen toxicity and idiosyncratic hypersensitivity reactions are the most common causes, idiosyncratic hypersensitivity reactions seem to be the most common life-threatening cause of<unk> .  With the presentation of systemic complications and mortality close to 80%, a multidisciplinary management approach of<unk>  in an intensive care unit that is directed towards the treatment of its etiology and complications along with a<unk>  transplantation is mandatory.
Acute liver failure
Acute renal failure
Acute kidney failure
Acute kidney injury
Hepatic failure
Hepatic encephalopathy
Water intoxication
Hepatopulmonary syndrome