The incidence of<unk>  is estimated to vary from 0.01 to 200 per 100,000 individuals in endemic countries. The case fatality rate of<unk>  is less than 2% when untreated. The majority of disease is reported in Mediterranean basin, South and Central America, Eastern Europe, Asia, Africa, the Caribbean and the Middle East. Patients of age group 20 and 45 years are affected. Men are more affected then women.
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