<unk>  <unk>  is a mycosis caused by the fungus Paracoccidioides brasiliensis or Paracoccidioides lutzii.<unk>  may be classified based on the onset and duration of symptoms.<unk>  may be classified into acute, subacute or chronic. The chronic form can be further subclassified into unifocal and multifocal. Spores of Paracoccidioides spp. are commonly transmitted via the respiratory route to the human host. Following transmission, Paracoccidioides spp. particles invade the terminal bronchioles and alveoli where granulomas are formed, but can be inactive for up to 40 years. On microscopic histopathological analysis, a "pilot's wheel" or a "Mickey mouse ears-like" appearance is a characteristic finding of<unk> . Among all infected patients 5% are acute with a more rapid and severe progression compared to the chronic subtype. Acute PMC primarily affects the reticuloendothelial system organs. Meanwhile, chronic<unk>  represents 90% of infected patients and has a slower progression. Patients with chronic<unk>  frequently develops pulmonary symptoms. Complications that can develop as a result of<unk>  are chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, bullae, pulmonary hypertension, dyspnea, adrenal gland insufficiency, dysphonia, laryngeal lesions (such as glottis estenosis), microstomia, seizures, and motor deficiency. The prognosis of<unk>  is good with adequate treatment. Without treatment, death is due to<unk>  related complications. Symptoms of acute<unk>  include high fever, generalized lymphadenopathy and pulmonary involvement with milliary lesions. Symptoms of acute<unk>  include dry cough, dyspnea and asthenia. Patients with acute<unk>  usually appear ill. Chronic<unk>  patients can appear healthy at early stages. Physical examination of patients with juvenile<unk>  is usually remarkable for lymphadenopathy and hepatosplenomegaly. Adult<unk>  is characterized by the presence of pulmonary abnormalities and skin lesions. Pharmacologic medical therapy is indicated in<unk> . The preferred regimens for both mild and moderate-to-severe include antifungals either azoles (such as itraconazole, ketoconazole, voriconazole) or amphotericin B and antimicrobials such as trimethoprim-sulfamethoxazole. Surgical procedures are usually reserved for patients with<unk>  sequelae. There are no vaccines and no other primary preventive measures available for<unk> .
Paracoccidioidomycosis
Chromoblastomycosis
Coccidioidomycosis
Histoplasmosis
Zygomycosis
Actinomycosis
Aspergillosis
Blastomycosis