<unk>  is a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction, inhibiting the stimulative effect of the neurotransmitter acetylcholine. The diagnosis is maily clinical, although ordering acetylcholine autoantibodies may sometimes be necessary. Physical examination of patients with<unk>  is usually remarkable for: downward lip corners and depress face, asymmetrical ptosis, incomplete eye closure, Cogan's lid twitch, peek sign, weakness of oropharyngeal muscles, respiratory muscle weakness, dropped head syndrome, and proximal muscle weakness. Thoracic immaging may reveal a mediastinal mass (thymoma). Edrophonium test is used in patients with obvious ptosis or ophthalmoparesis.<unk>  is treated medically with cholinesterase inhibitors or immunosuppressants and in selected cases with thymectomy.
Myasthenia gravis
Neurasthenia
Inflammatory myopathy
Lambert-Eaton myasthenic syndrome
Nemaline myopathy
Dermatomyositis
Critical illness polyneuropathy
Pyomyositis