<unk>  is a non-steroidal anti-inflammatory drug (NSAID) of the arylpropionic<unk>  (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300 mg twice daily. It is not recommended in children.
It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and it should be used with caution in renal disease.
Long-term use of<unk>  is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections.
The earliest reports of clinical use are from France in 1975 
It is marketed under the trade names Surgam, Surgamyl and Tiaprofen, and in generic formulations. A sustained-release preparation is available. It is isomer with Suprofen.
Tiaprofenic acid
Artemether
Moxidectin
Debrisoquine
Primaquine phosphate
Dihydroartemisinin
Ivermectin 
Piperaquine