Essential<unk>  arises from hematopoietic stem cells which give rise to megakaryocytes which give rise to platelets (thrombocytes), that are normally involved in blood clotting. Development of essential<unk>  is the result of a genetic mutation in the janus kinase 2 (JAK2) gene in 50% of the patients. Other genes that may be involved in the pathogenesis of essential<unk>  are CALR, MPL, and THPO genes. On microscopic histopathological analysis,<unk> , bone marrow hyperplasia with hyperlobated megakaryotic nuclei evident of thrombopoiesis are characteristic findings of essential<unk> .
Essential thrombocytosis pathophysiology
Idiopathic thrombocytopenic purpura pathophysiology
Thrombotic thrombocytopenic purpura pathophysiology
Thrombophilia pathophysiology
Glanzmann's thrombasthenia pathophysiology
Thrombocytopenia pathophysiology
Essential thrombocytosis risk factors
Polycythemia pathophysiology