The mainstay of therapy for motor symptoms of Parkinson disease are: Levodopa, dopamine agonists, monoamine oxidase (MAO) B inhibitors, anticholinergic agents, amantadine, catechol-O-methyl transferase (COMT) inhibitors, estrogen and other drugs such as Exenatide, uric acid, isradipine, nilotinib and GDNF infusion.
Treatment choices for some of the nonmotor symptoms of PD are:
psychosis: quetiapine, clozapine and pimavanserin.
Dementia: Cholinesterase inhibitors such as rivastigmine and donepezil.
Fatigue: Amantadine, methylphenidate and pemoline.
Depression: Amitriptyline, desipramine, citalopram ,paroxetine, venlafaxine, ropinirole and pramipexole.
Constipation: Increasing probiotics and fibers, lubiprostone and polyethylene glycol.
Sialorrhea: chewing gum and hard candy but in severe cases, botulinum toxin injection into salivary glands .
Sexual dysfunction: sildenafil (for male)
Ortostatic hypotention: Fludrocortisone, Sympathomimetic agents such as ephedrine, pseudoephedrine, methylphenidate and dextroamphetamine.
Parkinson's disease medical therapy
Pick's disease management
Wolff-Parkinson-White syndrome medical therapy
Dementia medical therapy
Spinal muscular atrophy treatment
Amyotrophic lateral sclerosis medical therapy
Botulism medical therapy
Amnesia medical therapy