Understading the pathogenesis of<unk>  involves a good knowlegde of the causative organisms. 
The only known reservoirs for H. influenzae in humans include, respiratory tract, conjunctival and genital surfaces. Pathogenicity of H. influenza is as a result of imbalance between the virulent factors of the organism and the host immune system. This immunity is enhanced when children are vaccinated with the purified polyribosylribitol phosphate (PRP). H. influenza type b capsule is antiphagocytic. Serum anit-purified polyribosylribitol phosphate (anti-PRP) antibody is important in the complement dependent phagocytosis and lyses of the bacteria.  IgA antibody accords the mucosa surface protection again attachment of the organism. The strategies deployed by a microbe to assist its survival and proliferation,  may or may not lead to disease process.<unk>  caused by H. influenza may therefore be considered as an accidental consequence of the microbial factors that permit its survival. Acute<unk>  pathogenesis is well exemplified by H. influenzae, with the ability to colonize mucosal surfaces and to spread contiguously or invade epithelial cells. It commonly disseminates within the bloodstream, or localizes to selected tissues among these is the epiglottis.  Microbial invasion of the bloodstream around the epiglottis leads to inflammatory response and tissue edema most apparent at the lingual surface of the epiglottis compared with the laryngeal surface. The extravasation of fluid leads to remarkable tissue swelling that may lead to respiratory obstruction and the other symptoms of<unk> . The pathogenesis of necrotizing<unk>  involves the infection with CMV or EBV usually in immunocompromised people. Affected patients are usually neutropenic and lymphopenic at presentation. CMV and EBV modulate the host's immune defense facilitating immune evasion and thereby predisposing the patient to superimposed infections.
The causative organism of necrotizing<unk>  is unclear.
Epiglottitis pathophysiology
Pharyngitis pathophysiology
Laryngeal cancer pathophysiology
Rhinitis pathophysiology
Adenoiditis pathophysiology
Tongue cancer pathophysiology
Desmoid tumor pathophysiology
Mastoiditis pathophysiology