When a diagnosis of plague is suspected, appropriate specimens for diagnosis should be obtained immediately and antimicrobial therapy should be started.  The drug of choice is either Streptomycin or Gentamicin, but Tetracyclines, Fluoroquinolones, and Chloramphenicol may also be effective.  The treatment regimen should be adjusted depending on the patient's age, medical history, underlying health conditions, and allergies.  Upon evidence of pneumonia, patients with suspected plague should be placed in isolation and managed under respiratory droplet precautions..  Supportive therapy includes aggressive monitoring and management for the possibility of complications such as septic shock, multiple organ failure, acute respiratory distress syndrome, and disseminated intravascular coagulopathy.
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Salmonellosis medical therapy