Kidneys reabsorb the filtered bicarbonate and excrete acid to maintain acid-base balance. HCO3 reabsorption is facilitated by Na-H and proton pumps. Collecting tubules serve the function of excretion of acid.<unk><unk><unk>  is described as any one of a number of disorders, in which either of above buffering mechanism is impaired. Potassium is the most common electrolyte abnormality that can be noticed with<unk><unk><unk> . It can be either hypokalemic<unk><unk><unk>  or hyperkalemic<unk><unk><unk> . Mode of inheritance can autosomal dominant or recessive depending upon type of disease abnormality, Common genes involved include ATP6V1B1,  ATP6V0A4, SLC4A1.
Renal tubular acidosis pathophysiology
Renal papillary necrosis pathophysiology
Renal tubular acidosis risk factors
Hyperosmolar hyperglycemic state pathophysiology
Acute tubular necrosis pathophysiology
Hypokalemia pathophysiology
Acute tubular necrosis risk factors
Renal papillary necrosis risk factors