<unk>  is a syndrome characterised by the association of<unk><unk><unk> ,<unk>  and skin anomalies. To date, only three cases (two brothers and one unrelated girl) have been reported. Central nervous system anomalies manifest as poor language skills, inappropriate behaviour (temper tantrums, aggressiveness), concentration and attention span difficulties and impulsiveness. Intellectual deficit was reported in two out of the three cases. Skin anomalies were hyperkeratosis, granular layer thickening, and sweat gland and melanocyte abnormalities.
Global developmental delay-osteopenia-ectodermal defect
Acral dysostosis - dyserythropoiesis
Osteoporosis -- oculocutaneous -- hypopigmentation syndrome
Lenz-Majewski hyperostotic dwarfism syndrome
Silver-Russell dwarfism
Lawrence-Moon syndrome
X linked mental retardation-precocious puberty-obesity
Greig cephalopolysyndactyly syndrome