<unk>  is the administration of<unk> g agents to remove heavy metals from the body.<unk>  has a long history of use in clinical toxicology.  For the most common forms of heavy metal intoxication – lead, arsenic, or mercury – a number of<unk> g agents are available.  The US Food and Drug Administration (FDA) only approves the use of calcium-disodium EDTA and DMSA, and not penicillamine and succimer, in the management of adult patients with lead poisoning.  Dimercaptosuccinic acid (DMSA) has been recommended for the treatment of lead poisoning in children by poison centers around the world.  Other<unk> g agents, such as 2,3-dimercapto-1-propanesulfonic acid (DMPS) and alpha lipoic acid (ALA), are used in conventional and alternative medicine.  The use of<unk>  as alternative<unk>  can prove fatal, particularly when disodium EDTA is confused for calcium EDTA and pushed rapidly intravenously in children.  Death due to hypocalcemia may occur.  Until recently, medical evidence did not support the effectiveness of<unk>  for any other purpose than the treatment of heavy metal poisoning.  Although there is randomized trials evidence that EDTA-based infusions decrease cardiovascular events in patients with prior heart attack, particularly in patients with diabetes, these indications are not currently recognized by the U.S. Food and Drug Administration (FDA).  The FDA also considers over-the-counter (OTC)<unk>  products to be "unapproved".
Chelation therapy
Therapeutic hypothermia
Transfusion therapy
Organocatalysis
Medical restraint
Maggot therapy
Artificial extracorporeal liver support
Corpus callosotomy