Primary<unk>  is cancer derived from lymphocytes (a type of white blood cell) that originates in the stomach. Most common cause of primary<unk>  is mucosa-associated lymphoid tissue (MALT)<unk>  and diffuse large B-cell<unk>  (DLBCL) of the stomach. Primary<unk>  may be classified according to histology into MALT<unk>  and DLBCL. MALT<unk>  can be further divided into H. pylori positive MALT<unk>  and H. pylori negative MALT<unk> . DLBCL can be divided into 3 subgroups germinal-center B-cell-like, activated B-cell-like, primary mediastinal DLBCL. The exact pathogenesis of primary<unk>  is not fully understood. Common symptoms of primary<unk>  include epigastric discomfort, anorexia, weight loss, nausea associated with or without vomiting, occult gastrointestinal bleeding, early satiety. Less common symptoms include ever and night sweats. Patients with primary<unk>  usually appear normal. Vital signs are within normal limits unless there is complication. Physical examination of patients with primary<unk>  is usually remarkable for palpable mass and peripheral lymphadenopathy.<unk>  must be differentiated from conditions with similar presentation like acute<unk> is, chronic<unk> is, atrophic<unk> is, Crohn's disease, gastroesophageal reflux disease, peptic ulcer disease,<unk> oma and<unk>  adenocarcinoma. Primary<unk>  commonly affects elderly patients in the fifth or sixth decade of life. Primary<unk>  is more prevalent in men than in women. Risk factors for<unk>  include Helicobacter pylori, long-term immunosuppressant drug therapy, HIV infection. The majority of patients with primary<unk>  present with nonspecific symptoms in the 5th decade of life. Early clinical features include epigastric pain, nausea, and vomiting. If left untreated, patients with<unk>  may progress to develop anorexia, weight loss, and early satiety. Common complications of<unk>  include perforation, hemorrhage, and obstruction. Prognosis is generally good, and complete remission can be achieved after 6-8 rounds of chemotherapy or following surgery. Upper gastrointestinal endoscopy with biopsy is the gold standard test for the diagnosis of<unk> . Laparotomy and laparoscopy should be performed when the patient presents with complications such as perforation or obstruction. An endoscopic ultrasound (EUS) will help assess the depth of<unk>  invasion and involvement of perigastric nodes. MALT<unk>  presents as superficial spreading or diffuse infiltrating lesion whereas diffuse large B cell<unk>  has a typical mass forming lesion appearance on endoscopic ultrasound. Imaging investigations including CT scans or endoscopic ultrasound are useful to stage disease.  Hematological parameters are usually checked to assist with staging and to exclude concomitant leukemia. An elevated LDH level may be suggestive of<unk> . There are no established measures for the primary and secondary prevention of<unk> .
Gastric lymphoma
Atrophic gastritis
Gastric diverticulum
CMV esophagitis
Tropical ulcer
Celiac disease
Barrett's esophagus
Eosinophilic esophagitis