Most of the toxic effects of TCAs are caused by four major pharmacological effects. TCAs have anticholinergic effects, cause excessive blockade of norepinephrine reuptake at the preganglionic synapse, direct alpha adrenergic blockade, and importantly they block sodium membrane channels with slowing of membrane depolarization, thus having quinidine like effects on the myocardium.
Tricyclic antidepressant overdose pathophysiology
Alcohol withdrawal pathophysiology
Heat stroke pathophysiology
Alcohol withdrawal secondary prevention
Alcohol withdrawal causes
Opioid indications
Self-induced water intoxication and schizophrenic disorders syndrome
Short-term effects of alcohol