Due to close similarity with many skin lesions, the diagnosis of Mammary Paget’s diseas may be delayed or many cases can be misdiagnosed. Immunohistochemical staining for cytokeratin, epithelial membrane antigen (EMA) and c-erb-B2 oncoprotein is useful for the differential diagnosis. Toker cells found in the epidermis of the nipple, close to the opening of lactiferous ducts, along the basal layer of the epidermis, are morphological and immunohistochemical similar to mammary Paget's cells. In contrast to Paget's cells which are strongly associated with both Ki-67 and Her-2/c-erbB-2 and these markers are mostly used to distinguish Paget's cells from Toker cells. In case of atypical Toker cells a combination of CD138 and p53 is very helpful in distinguishing these atypical cells from Paget's cells. Paget's disease of the breast must be differentiated from atopic dermatitis, eczema, psoriasis, malignant melanoma, Bowen's disease, basal cell carcinoma, benign intraductal papilloma, nevoid hyperkeratosis of the nipple and areola  (NHNA), squamous metaplasia of lactiferous ducts (SMOLD)/  Zuska's disease and pagetoid dyskeratosis.
Paget's disease of the breast differential diagnosis
Breast abscess differential diagnosis
Breast cancer other imaging studies
Paget's disease of the breast other diagnostic studies
Breast abscess other diagnostic studies
Paget's disease of the breast echocardiography or ultrasound
Paget's disease of the breast pathophysiology
Breast abscess primary prevention