The<unk>  <unk>  is a cellular stress<unk>  related to the endoplasmic reticulum. It is a stress<unk>  that has been found to be conserved between all mammalian species, as well as yeast and worm organisms. This article focuses on the mammalian<unk> .
The<unk>  is activated in<unk>  to an accumulation of<unk>  or misfolded<unk> s in the lumen of the endoplasmic reticulum. In this scenario, the<unk>  has two primary aims: initially to restore normal function of the cell by halting<unk>  translation and activate the signaling pathways that lead to increasing the production of molecular chaperones involved in<unk>  folding. If these objectives are not achieved within a certain time lapse or the disruption is prolonged, the<unk>  aims towards apoptosis.
Sustained overactivation of the<unk>  has been implicated in prion diseases as well as several other neurodegenerative diseases, and inhibiting the<unk>  could become a treatment for those diseases. Diseases subject to<unk>  inhibition include Creutzfeldt-Jakob disease, Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Unfolded protein response
Wnt signaling pathway
JAK-STAT signaling pathway
Phosphorylation cascade
Fatty acid metabolism
Rabi cycle
Endocannabinoid system
Gene expression