Hamartin and tuberin, which are encoded by TSC1 and TSC2 genes respectively, function as a complex which is involved in the control of cell growth and cell division. Thus, mutations at the TSC1 and TSC2 loci result in a loss of control of cell growth and cell division, and therefore a predisposition to forming tumors.
Tuberous sclerosis pathophysiology
Lesch-Nyhan syndrome pathophysiology
Bannayan-Riley-Ruvalcaba syndrome pathophysiology
Spinal muscular atrophy risk factor
Pott's disease pathophysiology
Progeria pathophysiology
Sezary syndrome pathophysiology
Ganglioglioma pathophysiology