<unk><unk><unk>  also known as<unk><unk>  cholangitis is an autoimmune cholestatic disease. The disease is chronic and slowly progressive. The exact pathogenesis of<unk><unk><unk>  is not fully understood. It is postulated that<unk><unk><unk>  is the result of antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Overexpression of Bcl-2 in small apoptotic<unk>  epithelial cells and cell lineage-specific lack of glutathione prevents loss of immunogenicity of the PDC-E2 component after apoptosis of<unk>  epithelial cells which finally results in autoimmunity.<unk><unk><unk>  may be familial and is related to factors inherited maternally.<unk><unk><unk>  is strongly associated with a variety of rheumatologic conditions, most commonly Sjogren's syndrome. On gross pathology, characteristic findings of<unk><unk><unk>  include hepatomegaly, splenomegaly, and<unk>  (in late stage). On microscopic histopathological analysis, asymmetric destruction of the intralobular bile ducts within portal triads is characteristic findings of<unk><unk><unk> .
Primary biliary cirrhosis pathophysiology
Alcoholic hepatitis pathophysiology
Autoimmune hepatitis pathophysiology
Primary sclerosing cholangitis pathophysiology
Peliosis hepatis pathophysiology
Non-alcoholic fatty liver disease pathophysiology
Hepatitis E pathophysiology
Hepatitis C pathophysiology