The development of pancreatic cancer is influenced by complex interactions between several cellular signaling pathways that include inactivation of tumor suppressor genes, activation of oncogenes and deregulation of molecules in various signaling pathways. Some of the important tumor suppressor genes involved are p53, p16, p27CIP1, DPC4 and BRCA2. These tumor suppressor genes are commonly inactivated by deletion, hypermethylation or mutation. The oncogenes involved in the pathogenesis of pancreatic cancer include Ras, Cox-2, Akt-2, Notch, Cyclin- D1 genes. Signal transduction pathways such as  EGFR, Akt, NF-kB and Hedgehog pathways undergo genomic alterations and crosstalk between these pathways plays an important role in pancreatic tumorigenesis.
Pancreatic cancer pathophysiology
Chronic pancreatitis pathophysiology
Pancreatic cancer risk factors
Pancreatic cancer treatment by stage
Gallbladder cancer pathophysiology
Zollinger-Ellison syndrome pathophysiology
Pancreatic pseudocyst pathophysiology
H.pylori gastric adenocarcinoma pathophysiology