The<unk> -alpha<unk>  enzyme is responsible for converting testosterone to dihydrotestosterone (DHT) which is a more potent form playing major roles in male sexual development. 
While Testosterone leads the development of internal male genitalia, DHT develops the external male genitalia. Children with<unk> -alpha<unk>  deficiency suffers from defective external genitalia and ambiguous genitalia.
5-alpha-reductase deficiency pathophysiology
Delayed puberty pathophysiology
Androgen insensitivity syndrome pathophysiology
17 alpha-hydroxylase deficiency risk factors
21-hydroxylase deficiency pathophysiology
Polycystic ovary syndrome pathophysiology
11β-hydroxylase deficiency risk factors
Struma ovarii pathophysiology