<unk>  arises from an immature cytotoxic T-cell clonally expressing the γδ T-cell receptor. Gamma delta (γδ) T<unk> s constitute 1% to 5% of the circulating lymphocytes in human blood. These<unk> s preferentially home in on some epithelial rich tissues and sinusoidal areas of the splenic red pulp where they represent up to 30% of the whole T-cell population.<unk>  γδ T-cell lymphoma (HSTCL) is a rare aggressive subtype of extra nodal lymphoma. Genes involved in the pathogenesis of<unk>  include isochromosome 7q, TRGά, and T-cell receptor (TCR) Gamma/Delta genes. On gross pathology, Diffuse enlargment of liver and spleen are characteristic findings of<unk> . On microscopic histopathological analysis, monotonous appearance, small amount of cytoplasm, and inconspicuous nucleoli are characteristic findings of neoplastic<unk> s of<unk> . There are no established causes for<unk> .<unk>  is a common disease that tends to affect young adults and adolescents. Males are more commonly affected with<unk>  than females. There are no established risk factors for<unk> . According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for<unk> .<unk>  must be differentiated from other diseases such as splenic marginal zone lymphoma, cutaneous T<unk>  lymphoma, extranodal NK-T-cell lymphoma, and angioimmunoblastic T-cell lymphoma. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor. According to the Lugano classification, there are four stages of<unk>  based on the number of nodes and extranodal involvement. The most common symptoms of<unk>  include fever, fatigue, weight loss, skin rash, night sweats, skin rash, chest pain, abdominal pain, bone pain, and painless swelling in the neck, axilla, groin, thorax, and abdomen. Common physical examination findings of<unk>  include fever, rash, ulcer, parlor, chest tenderness, abdomen tenderness, hepatomegaly, splenomegaly, bone tenderness, peripheral lymphadenopathy, and central lymphadenopathy. Laboratory tests for<unk>  include complete blood count (CBC), blood chemistry studies, cytogenetic analysis, flow cytometry, immunohistochemistry,  and immunophenotyping.CT scan may be helpful in the diagnosis of<unk> .MRI scan may be helpful in the diagnosis of<unk> . On abdominal ultrasound,<unk>  is characterized by hepatomegaly and splenomegaly. PET scan may be helpful in the diagnosis of<unk> . Other diagnostic studies for<unk>  include laparoscopy, laparotomy, bone marrow aspiration, and bone marrow biopsy. The predominant therapy for<unk>  is chemotherapy. Adjunctive stem<unk>  transplant may be required.
Hepatosplenic T cell lymphoma
Splenic marginal zone lymphoma
AIDS-related lymphoma
Amoebic liver abscess
Hepatic veno-occlusive disease with immunodeficiency
COVID-19-associated hepatic injury
Cytomegalic inclusion body disease
MALT lymphoma