Hirudin which is the prototype of<unk><unk><unk>  class of drugs has been studied in multiple trials with mixed results. Other drugs in this class include bivalirudin, argatroban, efegatran and inogatran. Bivalirudin is a synthetic analog of hirudin that binds reversibly to<unk>  and inhibits clot-bound<unk> .
Unstable angina / non ST elevation myocardial infarction direct thrombin inhibitors therapy
ST elevation myocardial infarction anticoagulant and antithrombotic therapy
Unstable angina / non ST elevation myocardial infarction factor Xa inhibitors therapy
Unstable angina / non ST elevation myocardial infarction anticoagulant therapy
Chronic stable angina treatment clopidogrel
Unstable angina / non ST elevation myocardial infarction unfractionated heparin therapy
ST elevation myocardial infarction primary percutaneous coronary intervention
Unstable angina / non ST elevation myocardial infarction low molecular weight heparin therapy