The natural<unk> s are generally synthesized from cholesterol in the gonads and adrenal glands. These forms of hormones are lipids. They can enter the cell membrane quite easily and enter right into the nuclei.<unk> s are generally carried in the blood bound to specific carrier proteins such as sex hormone binding globulin or corticosteroid binding globulin. Further conversions and catabolism occurs in the liver, other "peripheral" tissues, and in the target tissues.
Because<unk> s and sterols are lipid soluble, they can diffuse fairly freely from the blood through the cell membrane and into the cytoplasm of target cells. In the cytoplasm the<unk>  may or may not undergo an enzyme-mediated alteration such as reduction, hydroxylation, or aromatization. In the cytoplasm, the<unk>  binds to the specific receptor, a large metalloprotein. Upon<unk>  binding, many kinds of<unk>  receptor dimerize: two receptor subunits join together to form one functional DNA-binding unit that can enter the cell nucleus. In some of the hormone systems known, the receptor is associated with a heat shock protein which is released on the binding of the ligand, the hormone. Once in the nucleus, the<unk> -receptor ligand complex binds to specific DNA sequences and induces transcription of its target genes.
Steroid hormone
Sex steroid
Androgen
Thyroid hormone
Estrogen
Gonadotropins
Testosterone 
Progesterone 