<unk>  <unk>  is the transplantation of blood stem<unk> s derived from the bone marrow (that is, bone marrow transplantation) or blood. Stem<unk>  transplantation is a medical procedure in the fields of hematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer.
Stem<unk>  transplantation was pioneered using bone-marrow-derived stem<unk> s by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology and Medicine. Thomas' work showed that bone marrow<unk> s infused intravenously could repopulate the bone marrow and produce new blood<unk> s. His work also reduced the likelihood of developing a life-threatening complication called graft-versus-host disease.
The first physician to perform a successful human bone marrow transplant was Robert A. Good.
With the availability of the stem<unk>  growth factors GM-CSF and G-CSF, most<unk>  procedures are now performed using stem<unk> s collected from the peripheral blood, rather than from the bone marrow. Collecting peripheral blood stem<unk> s provides a bigger graft, does not require that the donor be subjected to general anesthesia to collect the graft, results in a shorter time to engraftment, and may provide for a lower long-term relapse rate.<unk>  remains a risky procedure with many possible complications; it has traditionally been reserved for patients with life-threatening diseases. While occasionally used experimentally in nonmalignant and nonhematologic indications such as severe disabling auto-immune disease and cardiovascular disease, the risk of fatal complications appears too high to gain wider acceptance.
Hematopoietic stem cell transplantation
Stem cell transplantation
R-EPOCH regimen
Follicular unit transplantation
Donor lymphocyte infusion
DA-EPOCH regimen
DA-R-EPOCH regimen
Radioimmunotherapy