<unk><unk> , a disorder of clonal late B-cells, arises from post-germinal center plasma cells that are normally involved in production of human immunoglobulins. Although the exact pathogenesis and the stage at which<unk>  cells arise from post-germinal B-cells remain unclear, a variety of factors have been implicated in pathogenesis of<unk><unk> . Of these, chromosomal abnormalities are thought to be the most important. It has been suggested that all cases of<unk><unk>  pass through MGUS. Renal involvement by<unk><unk>  is catergorized into three entities: light chain cast nephropathy, monoclonal immunoglobulin deposition disease, and amyloidosis. Osseous involvement by<unk><unk>  is based on cytokine and cellular interactions that lead to bone breakdown. On microscopic histopathological analysis, abundant eosinophilic cytoplasm, eccentrically placed nucleus, and  Russell bodies are characteristic findings of<unk><unk> .
Multiple myeloma pathophysiology
Primary amyloidosis pathophysiology
POEMS syndrome pathophysiology
Familial amyloidosis pathophysiology
HIV associated nephropathy pathophysiology
Renal amyloidosis pathophysiology
Myelofibrosis pathophysiology
Interstitial nephritis pathophysiology