<unk>  <unk>  is a family of intracellular non-receptor tyrosine kinases, ranging from 120-140 kDa in size, that transduce cytokine-mediated signals via the<unk> -STAT pathway.  Initially discovered in a PCR-based screen of kinases  and named ironically as "just another kinase" 1 & 2 (since they were two of a large number of new kinases discovered in the screen)<unk> 1 and<unk> 2 were ultimately published as<unk>  1 and<unk>  2.   The name is taken from<unk> , the Thessalian gatekeeper of heaven worshipped by the Romans; he is described as having two faces while the<unk> s possess two near-identical phosphate-transferring domains. One domain exhibits the kinase activity while the other stabilises the<unk> 's conformational structure enabling it express that activity.
Janus kinase
Rho GTPase
MAP kinase kinase kinase
STAT protein
Cyclin-dependent kinase
Adenylate cyclase
Mitogen-activated protein kinase
GTPase activating protein