The<unk>  protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient<unk>  signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease.
In mice loss of signaling by any member of the<unk>  family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive<unk>  signaling is associated with the development of a wide variety of types of solid tumor.<unk> -1 and<unk> -2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.
ErbB
Src 
BRAF
Ras 
Ras
XMC
AKT
APC 