<unk>  colitis is a non IgE immunological reaction against food protein antigens, particularly cow-milk and soy proteins. The exact mechanism is not known. It usually develops insidiously, and is thought to be T cell mediated. The activated T cells lead to recruitment of eosinophils and other polymorphonuclear cells into the intestinal tract, which then cause intestinal inflammation and damage. Some of these children may later develop specific IgE. Genetic influence may also play a role, since disease is sometimes present within families. On gross pathology, there is evidence of inflammation, with ulcers and friable, erythematous mucosa. On microscopy, the mucosa architecture is preserved with eosinophil infiltrates.
Allergic colitis pathophysiology
Irritable bowel syndrome pathophysiology
Ischemic colitis pathophysiology
Ulcerative colitis pathophysiology
Strongyloidiasis pathophysiology
Diverticulosis pathophysiology
Crohn's disease pathophysiology
Diverticulitis pathophysiology