<unk>  <unk>  is a group of inherited neurological disorders in which<unk>  accumulates in the basal ganglia, resulting in progressive dystonia, Parkinsonism, spasticity, optic atrophy or retinal degeneration and neuropsychiatric abnormalities.<unk>  have been associated with genes in synapse and lipid metabolism related pathways.
The group includes the following disorders:
Pantothenate kinase-associated<unk>  (PKAN) also known as<unk>  1 <unk> 1)
PLAN (PLA2G6-associated<unk> 
MPAN (Mitochondrial membrane protein-associated<unk> 
BPAN (Beta-propeller protein-associated<unk> 
FAHN (Fatty acid hydroxylase-associated<unk> 
Kufor–Rakeb syndrome
Neuroferritinopathy
Aceruloplasminemia
Woodhouse–Sakati syndrome
CoPAN (CoA synthase protein-associated<unk> 
Idiopathic<unk> <unk>  2B <unk> 2B)<unk>  3 <unk> 3)
Neurodegeneration with brain iron accumulation
Leukoencephalopathy with vanishing white matter
Progressive encephalopathy with edema, hypsarrhythmia and optic atrophy
Chronic white matter microvascular ischemic disease
Wernicke's encephalopathy
Early myoclonic encephalopathy
Transmissible spongiform encephalopathy
Paraneoplastic cerebellar degeneration