The<unk>  (also known as Jarisch-Herxheimer or herx) occurs when large quantities of toxins are released into the body as bacteria (typically Spirochetal bacteria) die, due to antibiotic treatment.
Typically the death of these bacteria and the associated release of endotoxins occurs faster than the body can remove the toxins via the natural detoxification process performed by the kidneys and liver.
It is manifested by fever, chills, headache, myalgias, and exacerbation of cutaneous lesions. Duration in syphilis is normally only a few hours but can be much longer in other diseases. The intensity of the<unk>  reflects the intensity of inflammation present.
The<unk>  has shown an increase in inflammatory cytokines during the period of exacerbation, including tumor necrosis factor alpha, Interleukin-6 and Interleukin-8.
Herxheimer reaction
DRESS syndrome
Anaphylactoid reaction
Cholinergic urticaria
Papular purpuric gloves and socks syndrome
Anaphylaxis
Dermatographic urticaria
Crush syndrome