Vasculitis such as<unk> s<unk>  is usually only suspected when a patient has had unexplained symptoms for a longer period of time. Determination of ANCAs can aid in the diagnosis, but positivity is not conclusive and negative ANCAs are not sufficient to reject the diagnosis. Cytoplasmic staining ANCAs that react with the enzymeproteinase 3 (cANCA) in neutrophils (a type of white blood cell) are associated with<unk> s.
If the patient has renal failure or cutaneous vasculitis, these are the most logical organs to obtain a biopsy from. Rarely, thoracoscopic lung biopsy is required. On histopathological examination, a biopsy will showleukocytoclastic vasculitis with necrotic changes and granulomatousinflammation (clumps of typically arranged white blood cells) on microscopy. The latter is the main reason for the appellation of "Wegener's<unk> ", although it is not an essential feature. Unfortunately, many biopsies can be non-specific and 50% provide too little information for the diagnosis of<unk> s.
Wegeners granulomatosis diagnostic criteria
Kawasaki disease classification
Rift valley fever imaging findings
Kawasaki disease diagnostic criteria
Goodpasture syndrome laboratory findings
Sarcoidosis other diagnostic studies
Behçet's disease classification
Sarcoidosis laboratory findings