The diagnosis of Down syndrome should be suspected in pre-natal assessment of fetuses on ultrasound examination. Second quad screen showing decreased alfa-fetoprotein (AFP) should raise the suspicion of fetal chromosomal abnormlaity. Pre-natal<unk> s of low AFP include Down syndrome, Edwards syndrome and Patau syndrome. In the newborn, Down syndrome should be<unk> ed from other congenital conditions presenting with hypotonia, poor feeding, poor growth and dysmorphic facial features. The<unk> s include isolated hypotonia, congenital hypothyroidism and Zellweger syndrome.
Down syndrome differential diagnosis
Cerebral palsy differential diagnosis
Noonan syndrome differential diagnosis
Mental retardation differential diagnosis
Fragile X syndrome differential diagnosis
Sheehan's syndrome differential diagnosis
Asperger syndrome differential diagnosis
Asperger syndrome risk factors