This evidence, often based on scientific research studies, of which the randomized controlled trial is the gold standard, typically suggests the recommended therapy is most likely to have an effect for the given condition.
Alternative<unk>  options, including switching to another<unk> , or augmenting the<unk>  with another<unk> , may be recommended if the<unk> -line therapy does not ease the symptoms, or produces intolerable side effects.
First-line treatment
Pulmonary nodule cost-effectiveness of therapy
Liver transplantation pre-surgical management
Neoadjuvant therapy
Platinum-based antineoplastic
Abarognosis
Cirrhosis cost-effectiveness of therapy
Drug of last resort