The pathogenesis of infantile hypertrophic pyloric stenosis is not completely understood. However, infantile hypertrophic pyloric stenosis may result from abnormal innervation of the pyloric smooth muscle. The chloride loss due persistent vomiting results in hypochloremia which impairs the kidney's ability to excrete bicarbonate. This factor significantly prevents correction of the alkalosis. The secondary hyperaldosteronism develops due to the hypovolaemia. The body's compensatory response to the metabolic alkalosis is hypoventilation resulting in an elevated arterial pCO2.
In relatives of probands of infantile hypertrophic pyloric stenosis patients and monozygotic co-twins the recurrence pattern did not depict a single major inheritance.
Pyloric stenosis pathophysiology
Intussusception risk factors
Hirschsprung's disease pathophysiology
Zenker's diverticulum pathophysiology
Meckel's diverticulum pathophysiology
Pyloric stenosis causes
Stomach cancer pathophysiology
Ileus risk factors