<unk>  is an enzyme irregularity that causes severe mental retardation, unusual facial features, brain malformation, and epileptic seizures due to an abnormally low amount of<unk>  in cells. The condition is congenital and is the result of receiving two defective recessive genes on the first chromosome that influence the functioning of the Krebs Cycle.
Fumarase deficiency
Aldolase A deficiency
ALA dehydratase deficiency
Alpha-ketoglutarate dehydrogenase deficiency
Biotinidase deficiency
Galactokinase deficiency
Pyruvate kinase deficiency
Fructose bisphosphatase deficiency