<unk>  cell carcinoma of the lung arises from the epithelial cells of the lung of the central bronchi to terminal alveoli, which are normally involved in the protection of the airways. The pathological irritation caused by cigarette smoke causes the mucus-secreting ciliated pseudostratified columnar respiratory epithelial cells that line the airways to be replaced by stratified<unk>  epithelium.<unk>  cell carcinoma of the lung has a central location and usually appears as a hiliar or perihiliar mass.<unk>  cell carcinoma of the lung is a rapidly growing cancer which may metastasize to various organs of the body. Genes involved in the pathogenesis of<unk>  cell carcinoma include several oncogenes, such as: EGFR, EML-4, KRAS, HER2, and ALK. On gross pathology, findings include central necrosis, cavitation, and invasion of peribronchial soft tissue. On microscopic histopathological analysis<unk>  cell carcinoma of the lung demonstrate large polygonal malignant cells containing keratin and intercellular bridges. On immunohistochemistry, findings associated with<unk>  cell carcinoma of the lung include the presence of p53 and high-molecular weight keratins for<unk>  cell carcinoma. Other<unk>  immunomarkers, include: CK5/6, CEA, 34BE12, TTF-1, and CK7.
Squamous cell carcinoma of the lung pathophysiology
Large cell carcinoma of the lung pathophysiology
Small cell carcinoma of the lung pathophysiology
Adenocarcinoma of the lung pathophysiology
Lung mass pathophysiology
Large cell carcinoma of the lung prevention
Bronchitis pathophysiology
Occupational lung disease risk factors