<unk>  mood disturbances are mainly the mood alterations or changes seen in the women during and after the delivery. It involes the complex<unk>  which is regulated by expression of different genes and neuroendocrine hormones. The genes playing important role are mainly Estrogen receptor alpha gene Polymorphisms in the serotonin transporter gene, 5-HTTgene encoding for MAOA and the gene encoding for Catechol-O-methyltransferase (COMT), Genetic variants for the TPH2 gene, SNP in OXT;  SNP in the OXTR gene and methylation state was detected in association with postpartum depression. Hemicentin 1 gene (HMNC1) along with the neuroendocrine hormones maily GABA, Glutamate, serotonin and , or dopamine.
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