The diagnosis of systemic<unk> ocytosis is based on the presence of one major criterion and one minor criterion or three minor criteria. Major criteria include the presence of multifocal dense infiltrates of<unk> <unk> s observed in bone marrow sections or other extra cutaneous organs. Four minor criteria include the presence >25% abnormal spindle-shaped<unk> <unk> s in bone marrow and/or tissues, detection of Kit mutation at codon 816 in bone marrow or extracutaneous organ(s), the expression of CD2 and
CD25 surface markers in C-kit positive<unk> <unk> s from bone marrow or other organs, and elevated serum tryptase levels >20 ng/mL.
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