A<unk>  is any disease that has the connective<unk> s of the body as a primary target of pathology.  Connective<unk>  is any type of  biological<unk>  with an extensive extracellular matrix that supports, binds together, and protects organs. These<unk> s form a framework, or matrix, for the body, and are composed of two major structural protein molecules, collagen and elastin. There are many different types of collagen protein in each of the body's<unk> s. Elastin has the capability of stretching and returning to its original length - like a spring or rubber band. Elastin is the major component of ligaments<unk> s that attach bone to bone) and skin.  In patients with<unk> , it is common for collagen and elastin to become injured by inflammation. Many<unk> s feature abnormal immune system activity with inflammation in<unk> s as a result of an immune system that is directed against one's own body<unk> s (autoimmunity).
Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. Collagen vascular disease is a somewhat antiquated term used to describe diseases of the connective<unk> s that typically include diseases which can be (but are not necessarily) associated with blood vessel abnormalities.<unk> s can have strong or weak inheritance risks, and can also be caused by environmental factors. Some signs, such as red skin at the base of the nails, can signify connective<unk>  disorders.
Connective tissue disease
Undifferentiated connective tissue disease
Neuromuscular junction disease
Neuromuscular disease
Congenital heart disease
Congenital myopathy
Fibromuscular dysplasia
Enthesopathy