MCTD is a systemic autoimmune disease that is characterized by overlapping symptoms of two or more systemic autoimmune diseases (SLE, RA, DM, polymyositis, and scleroderma) and the presence of antibodies against U1snRNP. Primary pathogenesis in MCTD include vasculopathy leading to tissue ischemia, immunological and inflammatory processes and fibrosis caused by excessive synthesis of collagen and other proteins of matrix. In MCTD associated conditions include secondary Sjogren’s syndrome and trigeminal neuralgia. A significant association between U1RNP disease and HLA-DR4 and DR154-61 is detected. Gross pathology of skin may include photo-distributed erythematosus annular lesions, papulosquamous lesions, Telangiectasia, and Sclerodactyly and the skin histopathological findings include poor and lichenoid interface dermatitis and suprabasilar exocytosis around necrotic keratinocytes.
Mixed connective tissue disease pathophysiology
Churg-Strauss syndrome pathophysiology
Undifferentiated connective tissue disease pathophysiology
Sarcoidosis pathophysiology
Buerger's disease pathophysiology
Lymphomatoid granulomatosis pathophysiology
Wegeners granulomatosis pathophysiology
Behçet's disease pathophysiology