<unk>  <unk>  is an autosomal dominant asymptomatic condition which occurs due to an inactivating missense mutation in the calcium-sensing receptor (CaSR) located on the short arm of the chromosome 3 (FBHH3q). CaSR is a plasma membrane G protein-coupled receptor which is expressed on the parathyroid glands and the renal tubules which has the ability to sense any changes in the circulating calcium concentrated and send this information through the signaling pathway to the parathyroid gland that modifies the PTH secretion.<unk>  can sometimes present with signs and symptoms of<unk>  such as confusion, fatigue, muscle weakness, constipation, anorexia, anhedonia, headaches, gastroesophageal reflux, polyuria, polydipsia, palpitations, nausea, vomiting, thinning of hair. Very rarely it can present with complications such as pancreatitis, gallstones, chondrocalcinosis. Patients with<unk>  should be differentiated from the primary hyperparathyroidism to avoid unnecessary parathyroidectomy. Calcium creatinine clearance can be used to differentiate between<unk>  and primary<unk> . Patients with<unk>  has a lifespan and quality of living similar to that of the general population.
Familial hypocalciuric hypercalcemia
Secondary hyperparathyroidism
Primary parathyroid hyperplasia
Pseudohyperparathyroidism
Pseudohypoparathyroidism
Pseudopseudohypoparathyroidism
Parathyroid adenoma
Hypoparathyroidism