Non Hodgkin's Lymphoma (NHL) represents a heterogeneous group of diseases with varied clinical presentation and histological appearance.It arises from cell of the lymphoid system, tumors are mainly derived from B lymphocytes, but are also from T lymphocytes, or natural killer cells. Lymphomas rise from different stages of B and T cell differentiation. Aberrations in the tightly controlled steps of B cell development can lead to oncogenesis. These aberrations are mainly seen in form of chromosomal translocation. About 85% of NHL's are of B-cell origin and only 15% are derived from T/NK cells. Two specific lymphomas, follicular lymphoma and diffuse large B cell lymphoma, account for about 65% of all non-Hodgkin lymphomas.
Non-Hodgkin lymphoma pathophysiology
B-cell lymphoma pathophysiology
Hodgkin's lymphoma pathophysiology
Hairy cell leukemia pathophysiology
Langerhans cell histiocytosis pathophysiology
Burkitt's lymphoma pathophysiology
Lymphadenopathy pathophysiology
Non-Hodgkin lymphoma risk factors