<unk>  is a condition produced by the bite of the recluse spiders (genus Loxosceles). It is the only proven cause of arachnogenic necrosis in humans.[n 1] While there is no known therapy effective for<unk> , there has been research on potential antivenoms and vaccines. Due to the number of diseases that may mimic<unk> , it is frequently misdiagnosed by physicians.[n 2]
Although there are up to thirteen different Loxosceles species in North America (eleven native and two nonnative), Loxosceles reclusa is the species most often involved in serious envenomation. In South America, L. laeta, L. intermedia (found in Brazil and Argentina), and L. gaucho (Brazil) are the three species most often reported to cause necrotic bites.
Loxoscelism
Phocomelia
Micrognathism
Sirenomelia
Gonochorism
Anodontia
Epispadias
Hypodontia