Brain temperature during the first 24 hours after resuscitation from cardiac arrest has a significant effect on survival and neurological recovery.
Fever (Tmax) during the first 48 hours is associated with a decreased chance of good neurological recovery (OR 2.26 [1.24, 4.12] for each 1°C over 37°C). Cooling to 32-34°C for 24 hours decreases chance of death (OR 0.74 [0.58, 0.95]) and increases chance of good neurological recovery (OR 1.40 [1.08,1.81]). Cooling to 32-34°C for 12 hours increases chance of good neurological recovery (OR 2.65 [1.02, 6.88]).
Therapeutic hypothermia
Cerebral shunt
Transcranial magnetic stimulation
Ischemic preconditioning
Medical restraint
Deep brain stimulation
Permissive hypercapnia
Chelation therapy