<unk> , a genital ulcer disease,  is a sexually transmitted disease caused by the fastidious Gram-negative bacterium Klebsiella granulomatis. Aragão & Vianna classified the agent as Calymmatobacterium granulomatis in 1913. However, sequencing analysis by Carter et al. revealed that the agent should be reclassified to Klebsiella granulomatis.<unk>  is rare in developed countries but is endemic in tropical and developing areas, including India, Papua New Guinea, the Caribbean, central Australia, and southern Africa.<unk>  must be differentiated from other diseases that cause genital ulcers without lymphadenopathy including: primary or secondary syphilis, chancroid, herpes simplex, amoebiasis, and squamous cell carcinoma. Sexually transmitted diseases characterized as genital ulcer diseases may present with similar manifestations and lesion characteristics. Pathogenesis of K. granulomatis is poorly characterized. The incubation period of Klebsiella granulomatis is debated and ranges from 1 to 360 days with a median time of 50 days.<unk>  starts as a papule or subcutaneous nodule which eventually ulcerates. The ulcer progresses to create areas of granulomatous tissue. Typical lesion characteristics include: beefy red color, nontender, emitting rank odor, elevated above skin, smooth and rolled edge, serpiginous outline. Physical examination of lesions can classify<unk>  into ulcerogranulomatous, hypertrophic, necrotic, and sclerotic variants. The standard method for identifying K. granulomatis and suggesting<unk>  as the diagnosis is a smear and stain of ulcer material. Microscopy of the stain reveals Donovan bodies within monocytes that may or may not be capsulated. Antimicrobial therapy is the mainstay of treatment for<unk> . Azithromycin 1 g PO once per week for at least 3 weeks and until all lesions have completely healed is the preferred regimen. Since there is no vaccine for<unk> , methods of primary prevention include: abstaining from sexual activity, limiting number of sexual partners and using a male or female condom. The goal of secondary prevention is to stop the spread of disease. Therefore infected individuals should abstain from sexual intercourse until symptoms reside.
Donovanosis
Talcosis
Berylliosis
Stannosis
Chalicosis
Kyphosis
Pyromania
Leprosy