<unk>  <unk>  is a program of development of biological cells characterized by loss of cell adhesion, repression of E-cadherin expression, and increased cell mobility.<unk>  is essential for numerous developmental processes including mesoderm formation and neural tube formation.
Several signal transduction pathways, such as Ras-MAPK and Wnt, have been shown to be involved in regulation of<unk> . In particular, Ras-MAPK has been shown to activate two related transcription factors known as Snail and Slug. Both of these proteins are transcriptional repressors of E-cadherin and their expression induces<unk> .
Twist, another transcription factor, has also been shown to induce<unk> , and is also implicated in the regulation of metastasis. Expression of FOXC2, an important player during embryonic development has been shown to induce<unk>  and regulate metastasis. Moreover, expression of FOXC2  is induced when<unk>  cells undergo<unk>  by Snail, Twist, Goosecoid, and TGF-beta 1.
Initiation of metastasis involves invasion, which has many phenotypic similarities to<unk> , including a loss of cell-cell adhesion mediated by E-cadherin repression and an increase in cell mobility.<unk>  is a characteristic feature of cells undergoing proliferation.  Cells expanding in-vitro, like beta cells- and<unk>  phenotype, of the pancreas, assume<unk>  phenotype.
Epithelial mesenchymal transition
Tissue expansion
Reticular formation
Neurulation
Hyperplasia
Dysplasia
Capitalization
Mitosis