<unk>  is a hydrolytic lysosomal glycosaminoglycan (GAG)-specific enzyme that is FDA approved for the treatment of Hunter syndrome (Mucopolysaccharidosis II, MPS II). There is a Black Box Warning for this drug as shown here.  Common adverse reactions include headache, pruritus, musculoskeletal pain, urticaria, diarrhea, cough, pyrexia, rash, vomiting.
Idursulfase
Galsulfase
Pegademase
Pegaspargase
Pegloticase
Dornase alfa
Epoetin alfa
Brinase