<unk> , also known as mucopolysaccharidosis type I (MPS I),<unk> 's disease and gargoylism, is a genetic disorder that results in the deficiency of alpha-L iduronidase, which is an enzyme that breaks down mucopolysaccharides.  Without this enzyme, the buildup of heparan sulfate and dermatan sulfate occurs in the body (the heart, liver, brain etc.). Symptoms appear during childhood and early death can occur due to organ damage.
Hurler syndrome
Smith Martin Dodd syndrome
Stickler syndrome
Saethre-Chotzen syndrome
Silver-Russell dwarfism
Landau-Kleffner syndrome
Kyrle syndrome
Laron syndrome