The<unk><unk>  of<unk> , also called the germ<unk>  of<unk> , is a<unk><unk>  of disease in which it is thought that a proximal cause of certain cases of<unk>  is the interaction of the developing fetus with pathogens  such as viruses, or with antibodies from the mother created in response to these pathogens (in particular, Interleukin 8).
Substantial research suggests that exposure to certain illnesses (e.g., influenza) in the mother of the neonate (especially at the end of the second trimester) causes defects in neural development which may emerge as a predisposition to<unk>  around the time of puberty, as the brain grows and develops.
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