<unk>  also known as  protein<unk> (TP53), is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor. It is important  in multicellular organisms as it helps to suppress cancer.<unk> has been described as "the guardian of the genome", "the guardian angel gene", or the "master watchman", referring to its role in conserving stability by preventing genome mutation.
The name<unk> is in reference to its apparent molecular mass: it runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But different ways of measuring molecular mass can produce different results. Based on calculations from its amino acid residues,<unk> s mass is actually only 43.7 kilodaltons. This difference is due to the high number of amino-acid proline residues in the<unk> protein which slow<unk> s migration on SDS-PAGE, thus making it appear larger. This observation is also seen in<unk> from other species including rodents, frogs, and fish.
P53 
APC 
PCNA
BRAF
P16 
OCLC
TCF21
Ras 