<unk>  pneumonia pathogenesis is different in its two subtypes: Exogenous form is the result of chronic body reaction to fatty substance in the alveoli.<unk>  reaches alveoli by aspiration or inhalation. Some mineral oils can cause lung injuries such as gasoline. Mineral oils can enter the tracheobronchial tree without causing cough reflex which will bother mucociliary transport system chronically. Injected<unk> s mechanism of further producing<unk>  pneumonia is more complicated. As the<unk>  goes inside the alveoli, it is trapped and hard to expectorate, this condition may be worsen by associated neurological and gastrointestinal disorders affecting swallowing or cough.<unk> s in alveoli form emulsion and then consumed by macrophages via phagocytosis. Since the alveolar macrophages cannot metabolize consumed fatty substance, oil is repeatedly released into alveoli after death of these macrophages. The oil released, elicits a giant-cell granulomatosis reaction. Pathogenesis of endogenous form is still not well understood however there are plenty of suggested mechanisms, one saying that endogenous<unk>  pneumonia can be caused by transbronchial dissemination of cancer cell breakdown products. Poorly differentiated adenocarcinoma cells secreting mucin is the most common neoplastic reason. Another mechanism suggested is anoxic tissue injury stimulating various enzymes such as phospholipase and monooxygenases. Infection changes to endogenous<unk>  pneumonia is generally localized in airways because the surrounding lung is already consolidated, limiting the spread of bacteria. On gross and microscopic histology will show well circumscribed, firm with prominent lymphatics on lung surface, inflammatory cells, and young fibroblasts. Reactive endarteritis and marked alveolar lining cell hyperplasia may also be seen.<unk> -laden foamy macrophages are part of pathology.
Lipoid pneumonia pathophysiology
Aspiration pneumonia pathophysiology
Community-acquired pneumonia pathophysiology
Cryptogenic organizing pneumonia pathophysiology
Aspergillosis pathophysiology
Air embolism pathophysiology
Lung abscess pathophysiology
Aspergillosis diagnostic criteria