<unk>  (also known as "enlarged lymph nodes") refers to lymph nodes which are abnormal in size, number, or consistency. Common causes of<unk>  are infection, autoimmune disease, or malignancy.<unk>  may be classified according to distribution into 2 groups: generalized<unk>  and localized<unk> . The pathogenesis of<unk>  is characterized by the inflammation of lymph nodes. This process is primarily due to an elevated rate of trafficking of lymphocytes into the node from the blood, exceeding the rate of outflow from the node. Lymph nodes may also be enlarged secondarily as a result of the activation and proliferation of antigen-specific T and B cells (clonal expansion).<unk>  is very common,  the estimated incidence of<unk>  among children in the United States ranges from 35%- 45%. Patients of all age groups may develop<unk> .<unk>  is more commonly observed among children. Common complications of<unk> , may include: abscess formation, superior vena cava syndrome, and intestinal obstruction.  Diagnostic criteria for malignant<unk> , may include: node > 2 cm, node that is draining, hard, or fixed to underlying tissue, atypical location (e.g. supraclavicular node), associated risk factors (e.g. HIV or TB), fever and/or weight loss, and splenomegaly. On the other hand, diagnostic criteria for benign<unk> , may include: node < 1 cm, node that is mobile, soft-or tender, and is not fixed to underlying tissue, typical location (e.g. supraclavicular node), no associated risk factors, and palpable and painful enlargement.<unk> boratory findings consistent with the diagnosis of<unk>  may include elevated<unk> ctate dehydrogenase (LDH), mild neutropenia, and leukocytosis. There is no treatment for<unk> ; the mainstay of therapy is treating the underlying condition.
Lymphadenopathy
Dermatological lesions
Skin nodules
Splenomegaly
Oral lesions
Abscess
Abdominal enlargement
Dental cavities