Brush cytology may be helpful in the diagnosis of<unk>  plastica and its complications. Brush cytology has the ability to increase the sensitivity of even a single biopsy carried out by endoscopic ultrasound. If bleeding is a concern in the patient, brush cytology is able to take samples of the mucosa without causing bleeds. Immunohistochemical staining then confirms the diagnosis of<unk>  plastica by the detection of signet ring cells. Peritoneal cytology can also be useful in those that are negative for metastasis elsewhere.
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