During the 4th week of gestation, formation of the atrial septum begins. Formation of the septum primum and septum secundum leads to the development of a foramen ovale which allows blood to flow from the right atrium to the left atrium in the fetus. Fusion of both septa's occurs after birth with increased left atrial pressure. The foramen ovale remains<unk>  in some people due to failure of fusion of the septum primum and septum secundum. This permits blood flow from the right atrium to the left atrium during periods of increased right atrial pressure. Some conditions associated with<unk>  foramen ovale include cryptogenic stroke, migraine with aura, and decompression sickness in divers.
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