<unk> 's<unk>  arises from endothelial cells, which are epithelial cells that normally lines the luminal surface of blood vessels and lymphatic vessels.<unk> 's<unk>  is mainly caused by an infection with Human herpes virus 8 (HHV-8), which is also known as<unk> 's<unk> -associated herpes virus (KSHV). The main gene involved in the pathogenesis of<unk> 's<unk>  is ORF73 gene, which encodes the viral latency-associated nuclear antigen (LANA-1).<unk> 's<unk>  is commonly associated with acquired immune deficiency syndrome (AIDS). On gross pathology, reddish, violaceous, or bluish-black macules and patches are characteristic findings of<unk> 's<unk> . On microscopic histopathological analysis, the presence of spindle cells with minimal nuclear atypia are characteristic findings of<unk> 's<unk> .
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