<unk>  is a putative cognition-enhancing drug with a novel mechanism of action.<unk>  blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4nM disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons.  In a murine model<unk>  is able to nearly completely reverse the senescence-related decline in cortical c-FOS, an effect which is blocked by atropine and MK-801, suggesting<unk>  can compensate for the age related decline in acetylcholine release.<unk>  also blocks homomeric KCNQ1 and KCNQ4 voltage gated potassium channels which contribute to vascular tone with substantially less selectivity than KCNQ2/3.
Linopirdine
Tiocarlide
Eluxadoline
Lisuride
Orlistat
Lixisenatide
Cobicistat
Iofendylate