<unk>  (LCC) is a type of non-small<unk>  carcinoma of the lung, that accounts for 5% and 10% of all lung cancers. According to the World Health Organization (WHO),<unk>  can be classified into 6 sub-types: giant-cell carcinoma of the lung, basaloid<unk> , clear<unk>  carcinoma of the lung, lymphoepithelioma-like carcinoma of the lung,<unk> -cell lung carcinoma with rhabdoid phenotype, and<unk> <unk>  neuroendocrine carcinoma of the lung.<unk>  arises from the epithelial<unk> s of the lung, which are usually involved in the lining of the airways. The pathological irritation causes the mucus-secreting ciliated pseudostratified columnar respiratory epithelial<unk> s to be replaced by stratified squamous epithelium.<unk>  has a peripheral location, and usually appears as a well-circumcised mass attached to the thoracic wall.<unk>  is a rapidly growing cancer and frequently has early metastasis. The histologic subtype of<unk> <unk>  neuroendocrine tumor is related with a more aggressive presentation. Genes involved in the pathogenesis of<unk>  include: EGFR, LKB1, KRAS, HER2, and ALK. A  hallmark feature of<unk> , is the histopathological characteristics, that include:<unk> r size of the anaplastic<unk> s, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin.<unk>  accounts for less than 2% of all cancer deaths. The incidence of<unk>  increases with age; the median age at diagnosis is approximately 60 years.<unk>  is most frequently diagnosed among people among 55 to 65 years old. Males are more commonly affected with<unk>  than females. Asian race has a higher incidence of lymphoepithelioma-like<unk>  lung<unk>  carcinoma compared to the white race. Combination chemotherapy regimens using platinum-based chemotherapy and specific-inhibitors is the treatment of choice for the management of patients with non-small<unk>  lung cancers, such as<unk> . Chemotherapy may be required upon histological subtype of<unk> , molecular testing (presence of genetic mutations), and staging.  The predominant treatment of choice for<unk>  is neoadjuvant chemotherapy or adjuvant chemotherapy, followed or preceded by surgical resection.
Large cell carcinoma of the lung
Small cell carcinoma of the lung
Sarcomatoid carcinoma of the lung
Adenocarcinoma of the lung
Non small cell lung cancer
Mesothelioma
Squamous cell carcinoma of the lung
Hemangioendothelioma