<unk>  <unk> 's tumor", or "Malignant lymphoma,<unk> 's type") is a cancer of the lymphatic system (in particular, B lymphocytes).<unk>  was first described by Denis Parsons<unk> , a surgeon, in 1958 while working in equatorial Africa.<unk>  may be classified according to WHO classification into 3 clinical variants: endemic<unk> , sporadic<unk> , and immunodeficiency-associated<unk> . Gene involved in the pathogenesis of<unk>  includes c-myc. On gross pathology, ulceration and discharge are characteristic findings of<unk> . On microscopic histopathological analysis, "starry sky" appearance is characteristic finding of<unk> . There are no established causes for<unk> .<unk>  must be differentiated from other diseases  such as Hodgkin's lymphoma, diffuse large B cell lymphoma, follicular lymphoma, Mucosa-Associated Lymphatic Tissue lymphoma (MALT), small cell lymphocytic lymphoma, and mantle cell lymphoma (MCL).<unk>  is a common disease that tends to affect children or young adults. Males are more commonly affected with<unk>  than females.<unk>  usually affects individuals of the African race. Common risk factors in the development of<unk>  may be HIV/AIDS and post-transplant immunosuppression. According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for<unk> . The prognosis varies with the age, children have the most favorable prognosis.<unk>  in children is associated with a 5 year survival rate of 90%. The presence of metastasis in bone marrow or CNS is associated with a particularly poor prognosis among patients with<unk> . According to the Murphy staging system, there are four stages of<unk>  based on the number of nodes and extra nodal involvement. Laboratory tests for<unk>  include complete<unk> ood count (CBC),<unk> ood chemistry studies, immuno histochemistry, HIV<unk> ood test, flow cytometric analysis, and cytogenetics. Chest and knee x ray may be helpful in the diagnosis of<unk> . CT and MRI may be helpful in the diagnosis of<unk> . Lymph node or extra nodal tissue biopsy is diagnostic of<unk> . PET and bone scan may be helpful in the diagnosis of<unk> . Other diagnostic studies for the diagnosis of<unk>  include bone marrow biopsy and spinal fluid examination. The predominant therapy for<unk>  is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required. Surgical intervention is not recommended for the management of<unk> .
Burkitt's lymphoma
Hodgkin's lymphoma
AIDS-related lymphoma
Thymic carcinoma
Diffuse large B cell lymphoma
Primary effusion lymphoma
Waldenström's macroglobulinemia
B-cell lymphoma