<unk> is a tumor suppressor gene that is named after, and provides instructions for making, a protein called tumor protein 53 <unk> . Through the effect of the protein that it produces,<unk> is a tumor suppressor gene, which means that it regulates the cycle of cell division by keeping cells from growing and dividing too fast or in an uncontrolled way.
The<unk> tumor protein is located in the nucleus of cells throughout the body and can bind directly to DNA. When the DNA in a cell becomes damaged by agents such as toxic chemicals or ultraviolet (UV) rays from sunlight, this protein plays a critical role in determining whether the DNA will be repaired or the cell will undergo programmed cell death (apoptosis). If the DNA can be repaired,<unk> activates other genes to fix the damage. If the DNA cannot be repaired, the<unk> tumor protein prevents the cell from dividing and signals it to undergo apoptosis. This process prevents cells with mutated or damaged DNA from dividing, which helps prevent the development of tumors.
Because the<unk> tumor protein is essential for regulating cell division, it has been nicknamed the "guardian of the genome."
The<unk> gene is located on the short (p) arm of chromosome 17 at position 13.1, from base pair 7,512,463 to base pair 7,531,641.
TP53 
APC 
BRAF
PCNA
TCF21
OCLC
P16 
Ras