Gastric<unk>  may occur secondary to a variety of causes including H. pylori and gastric<unk>  have strong correlation. This is related to nitric oxide accumulation produced by inflammatory cells responding to H. pylori infection. The<unk>  of<unk><unk>  depends upon the histologic subtype. K-ras mutations is found in invasive<unk> s and intestinal metaplasia. Inactivation of p53 in gastric epithelial cells reduce their ability to undergo apoptosis. DNA methylation of gene promoters can silence the expression of CDH1. Beta-catenin mutation is a frequent cause of Wnt pathway activation in gastric<unk> . Diffuse gastric carcinomas do not have a precancerous lesion. They are highly metastatic with a poorer prognosis than intestinal<unk> s. When the entire<unk>  wall is infiltrated, it results in a rigid thickened<unk>  wall called linitis plastica. There are many diseases associated with gastric<unk>  such as, hereditary diffuse gastric<unk> , gastric adenocarcinoma, proximal polyposis of the<unk> , Lynch syndrome, familial adenomatous polyposis, Li-Fraumeni syndrome, Peutz Jeghers syndrome, juvenile polyposis, hereditary breast and ovarian<unk>  syndrome and Cowden's syndrome. There are five gross pathological types of gastric<unk> ; superficical, ulcerative, infiltrative ulcerative, diffuse infiltrative, and unclassified. There are two major histological classifications for gastric<unk>  including Japanese classification and WHO classification. The main two types are intestinal type adenocarcinoma and diffuse type adenocarcinoma.
Stomach cancer pathophysiology
Stomatitis pathophysiology
Helicobacter pylori infection pathophysiology
Odynophagia pathophysiology
H.pylori gastric adenocarcinoma pathophysiology
Hypopharyngeal cancer pathophysiology
Gastritis pathophysiology
Pyloric stenosis pathophysiology