After the repeated episodes of a diffuse alveolar hemorrhage, the alveolar macrophages are responsible for the repeated clean up of excess blood. As the macrophages degrade the erythrocytes, the excess iron from heme degradation within the alveolar macrophages stimulates intracellular ferritin molecules. Further processing of the ferritin leads to hemosiderin complexes.9see below for more information). In the early stages of pulmonary<unk> , interstitial and intra-alveolar hemorrhage predominate, with collections of both free hemosiderin and hemosiderin-filled macrophages found in the alveolar spaces and the interstitium. When the disease progresses, interstitial fibrosis ensues. Pulmonary<unk>  can occur either as a primary lung disorder (Idiopathic pulmonary<unk>  or as the sequela to other pulmonary, cardiovascular, or immune system disorder.
Hemosiderosis pathophysiology
Polycythemia pathophysiology
Macrocytic anemia pathophysiology
Cryoglobulinemia risk factors
Hemolytic anemia pathophysiology
Hemosiderosis laboratory findings
Cryoglobulinemia causes
Retinitis risk factors