Adrenoleukodystrophy is an X-linked disease characterized by excessive accumulation of very long chain fatty acids (VLCFA), originally described by Moser et al in 1981. The gene, ABCD1, transfers fatty acids into peroxisomes to undergo β-oxidation. However, VLCFA accumulation is necessary but not sufficient for the pathogenesis. The CNS pathology suggests the role of cellular and humoral immune processes.
Adrenoleukodystrophy pathophysiology
Multiple sclerosis pathophysiology
Amyotrophic lateral sclerosis pathophysiology
Dermatomyositis pathophysiology
Pathophysiology of multiple sclerosis
Polymyalgia rheumatica pathophysiology
Transverse myelitis pathophysiology
Adrenoleukodystrophy epidemiology and demographics