<unk>  or CUP is the diagnosis of metastatic<unk>  when the anatomic site of<unk>  remains unidentified.<unk>  is common, and it accounts for 2–5% of all<unk> s.<unk>  may be classified according to pathology findings into 4 groups: adenocarcinomas, poorly differentiated carcinomas, squamous cell carcinomas, and carcinomas with neuroendocrine differentiation. The majority of patients with<unk>  may be initially asymptomatic. Early clinical features include fatigue, weight-loss, and loss of appetite. If left untreated, the majority of patients with<unk>  may progress to develop multiple organ failure, heart failure, and death. The treatment for<unk>  will depend on several factors, such as: metastatic<unk> , biopsy findings, patients age, and performance status. The 5-year survival of patients with<unk>  is less than 2%.
Cancer of unknown primary origin
Non-Hodgkin lymphoma
Hodgkin's lymphoma
Papillary carcinoma of the thyroid
B-cell lymphoma
Thymic carcinoma
AIDS-related lymphoma
Adrenocortical carcinoma