<unk> (ophthalmic) is an alpha-2 adrenergic agonist that is FDA approved for the treatment of open-angle glaucoma or ocular hypertension.   Common adverse reactions include hypertension, contact dermatitis, erythema, flushing, sensation of burning of skin, xerostomia, somnolence, allergic conjunctivitis, burning sensation in eye, conjunctival discoloration, conjunctival hyperemia, follicular conjunctivitis, acute hypersensitivity reaction, itching of eye, lid retraction, and visual disturbance.
Brimonidine 
Clonidine
Metergoline
Phenylephrine 
Penbutolol
Bietaserpine
Avacopan
Clopamide