<unk>  is a clinical state indicating the permanent cessation of ovarian function. Perimenopause refers to the period of transitioning before<unk>  characterised by irregular menstrual cycles. The diagnosis of<unk>  is made retrospectively based on the absence of menstrual cycles for 12 months. The average age of<unk>  is 51 years. Women can have symptoms of hot flashes, night sweats, sleep disturbance, mood changes, decreased libido, vaginal dryness, dyspareunia, etc. Women with intolerable symptoms can be treated with hormonal and non hormonal therapy. Conditions where<unk>  can occur early are primary ovarian insufficiency, bilateral oophorectomy, chemotherapy and radiation induced.
Menopause
Menstruation
Sexual maturity
Premenstrual syndrome
Secondary amenorrhea
Pregnancy
Menstrual cycle
Anovulation