<unk>  glomerulonephritis is caused by immune complex formation in the glomerulus. The immune complexes are formed by binding of antibodies to antigens in the glomerular basement membrane. The antigens damage the basement membrane and activates the immune response. The immune complex serves as an activator that triggers a response from the complement system. .PLA2R antigen detected within immune deposits by immunofluorescence of the biopsy specimen. Formation of the immune complex. Immune complex formation results in release of cytokines which release membrane attack complex C5-C9. Release of C5-C9 lead to injury of podocyte which causes loss of glomerular permeablity. The damage to podocyte reults in proteinuria.
Membranous glomerulonephritis pathophysiology
Interstitial nephritis pathophysiology
Post-streptococcal glomerulonephritis pathophysiology
Renal papillary necrosis pathophysiology
Renal amyloidosis pathophysiology
Contrast induced nephropathy pathophysiology
Analgesic nephropathy pathophysiology
Acute tubular necrosis pathophysiology