<unk>  <unk>  was first described in the 1950s and has had a variety of names including chronic active hepatitis, lupoid hepatitis, plasma cell hepatitis and<unk>  chronic active hepatitis.  It is characterized by circulating autoantibodies and a high serum globulin level. It is important to distinguish<unk>  from other forms of liver disease, as a large percentage of patients respond to therapy and therapy has been shown to delay transplantation, improve the quality of life as well as prolong survival. Lupoid hepatitis (also called<unk>  is an<unk>  disease which causes liver cirrhosis. It may be associated with systemic lupus erythematosus (SLE), or other connective tissue disorders. Around 60% of patients have chronic hepatitis that may mimic viral hepatitis, but without serologic evidence of a viral infection. The disease usually affects women and is strongly associated with anti-smooth muscle auto-antibodies.<unk>  is a condition in which the patient's own immune systems attacks the liver causing inflammation and liver cell death. The condition is chronic and progressive. Although the disease is chronic, many patients with<unk>  present acutely ill with jaundice, fever and sometimes symptoms of severe hepatic dysfunction, a picture that resembles acute hepatitis.<unk>  usually occurs in women (70 %) between the ages of 15 and 40. Patients usually present with evidence of moderate to severe hepatitis with elevated serum ALT and AST activities in the setting of normal to marginally elevated alkaline phosphatase and gamma-glutamyltranspeptidase activities. The patient will sometimes present with jaundice, fever, and right upper quadrant pain and occasionally systemic symptoms such as arthralgias, myalgias, polyserositis and thrombocytopenia. Some patients will present with mild liver dysfunction and have only laboratory abnormalities as their initial presentation. Others will present with severe hepatic dysfunction. Mainstay treatment of<unk>  is pharmacotherapy. Corticosteroids alone or in combination with immunosuppressants are commonly used. Liver transplantation is indicated when medical therapy fails, decompensated chronic liver disease, fulminant hepatic failure, hepatocellular carcinoma and MELD score of >15 or a Child-Pugh score of >10277.
Autoimmune hepatitis
Alcoholic hepatitis
Lupoid hepatitis
Ischemic hepatitis
Benign intrahepatic cholestasis
Alcoholic liver disease
Non-alcoholic fatty liver disease
Primary biliary cirrhosis