<unk><unk>  is an autosomal recessive disorder characterised by functional defects in the cilia resulting in an abnormal mucociliary clearance.Epithelial cells containing motile cilia are localised in the respiratory tree, oviduct, sperms, ventricles of the brain and embryonic node. Defects in the epithelial cells accounts for the majority of symptoms of<unk>  including sinusitis, otitis media and bronchiectasis.  Situs inverses(in some patients) and rarely hydrocephalus. While the understanding of the cellular and molecular mechanisms responsible for these symptoms has progressed recently, genetic analysis has identified mutations in only two axonemal dynein genes that can account for abnormal cilia structure.Nasal nitric oxide Nno is the screening test that could be performed initially to diagnose<unk>  initially followed by electron microscopy to confirm the diagnosis. Treatment mainly focuses on treating underlying conditions that can exacerbate<unk>  such as antibiotics for rhino-sinusitis, bronchiectasis, and sinusitis.
Primary ciliary dyskinesia
Cystic fibrosis
Stendhal syndrome
Olmsted syndrome
Goldenhar syndrome
Wolfram syndrome
Cryopyrin-associated periodic syndrome
Esophageal motility disorder