<unk>  is a systemic, immune- mediated inflammatory arthritis, associated with psoriasis. The etiology is not clearly understood. It may be caused by complex interaction between genetic, immunologic and environmental mechanisms which act as triggers for the disease development. Both<unk>  and psoriasis have been shown  to have strong familial predisposition.<unk>   present with<unk> in and stiffness in the affected joints. According to Moll and Wright criteria, joint involvement<unk> ttern in<unk>  include distal arthritis usually involving distal interphalangeal joints, asymmetric oligoarthritis, symmetric polyarthritis, arthritis mutilans, spondylitis, and sacroiliitis. Other symptoms include enthesitis <unk> in and tenderness at the insertion of tendons and ligaments to the bone), dactylitis ( sausage like finger or toe swelling),<unk>  skin plaques, nail changes (pitting, hyperkeratosis, and nail destruction). The<unk> thophysiology of<unk>  consists of interactions between cytokines, dendritic cells, and T lymphocytes.<unk>  must be differntiated from other inflammatory arthritides including rheumatoid arthritis, ankylosing spondylitis, reactive arthritis, gout, pseudogout, osteoarthritis, arthritis associated with inflammatory bowel disease. The prevalence of<unk>  in general population  ranges from 60 - 250 cases per 100,000  individuals and the prevalence of<unk>  among psoriasis<unk> tients is 11,000 per 100,000 individuals. The mainstay of therapy for<unk>  NSAIDs,  conventional DMARDs (eg, methotrexate, sulfasalazine, cyclosporine) and biologic DMARDs (eg, TNF inhibitors),  anti IL therapy (eg,  secukinumab, ustekinumab). Other treatment options include physiotherapy,<unk> tient education about disease and joint preservation and surgery.<unk>  is associated with a number of comorbid conditions due to circulating immunoglobulins, antibodies including metabolic syndrome, increased insulin resistance, atherosclerosis, stroke, hypertension, uveitis, osteoporosis and depression.<unk> tients are monitored regularly for disease activity, drug efficacy, adverse effects and associated comorbid conditions.
Psoriatic arthritis
Reactive arthritis
Crystal arthritis
Rheumatoid arthritis
Juvenile idiopathic arthritis
Enteropathic arthropathy
Oligoarthritis
Relapsing polychondritis