Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage. In the hereditary type of Glanzmann's thrombasthenia GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative disorder. The autoantibodies production is the main cause of acquired Glanzmann's thrombasthenia. Common risk factors that increase autoantibodies production in acquired Glanzmann thrombasthenia include Acute lymphoblastic leukemia, Non-Hodgkin’s lymphoma, Multiple myeloma, Hairy cell leukemia and Myelodysplastic syndrome. There is no single diagnostic study of choice for the diagnosis of Glanzmann's thrombasthenia, but it can be diagnosed based on Platelet aggregation assays which is panel of assays measuring platelet aggregation and activation in vitro. using like ADP, arachidonic acid, collagen, epinephrine, thrombin, and ristocetin.The diagnosis of Glanzmann thrombasthenia is confirmed through monoclonal antibody testing and flow cytometry. DDAVP prevents bleeding after dental extraction and minor surgery in patients with milder platelet defects. Glanzmann's thrombasthenia patients need regular dental visits and must maintain good oral hygiene because the recurrence of gingival bleeding is more in them. These patient should avoid contact sports. Estrogens, platelet transfusion, antifibrinolytic agents, and recombinant human factor VIIa are some other therapies used for treatment/prevention.
Glanzmann's thrombasthenia patient information
Glanzmann's thrombasthenia physical examination
Glanzmann's thrombasthenia laboratory findings
Essential thrombocytosis diagnostic criteria
Heparin-induced thrombocytopenia laboratory findings
Heparin-induced thrombocytopenia physical examination
Macrocytic anemia patient information
Thrombotic thrombocytopenic purpura physical examination