N-Acetylaspartylglutamic acid<unk>  or<unk>  is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system.<unk>  consists of  N-acetylaspartic acid (NAA) and glutamic acid coupled via a peptide bond.<unk>  was discovered as a nervous system-specific peptide in 1965 by Curatolo and colleagues but was not extensively studied. It meets the criteria for a neurotransmitter, including being concentrated in neurons, packed in synaptic vesicles, released in a calcium-dependent manner, and hydrolyzed in the synaptic space by enzymatic activity.<unk>  activates a specific receptor, the metabotropic glutamate receptor type 3. It is  synthesized enzymatically from its two precursors and catabolized by<unk>  peptidases in the synapse. The inhibition of the latter enzymes has potentially important therapeutic effects in animal models of several neurologic conditions and disorders.
Under the INN spaglumic acid,  <unk>  is used as an antiallergic medication in eye drops and nasal preparations.
N-Acetylaspartylglutamate
N-Acetylglutamic acid
Magnesium aspartate
Glycocyamine
Tetrahydropyran
Choline theophyllinate
Tidiacic arginine
Sodium glycerophosphate