<unk>  is a dermatological disease caused by Corynebacterium minutissimum.<unk>  was first officially identified by Burchardt in 1859. Corynebacterium minitissium was first isolated and discovered to be the cause of<unk>  in 1961.<unk>  usually presents with erythematous lesions, maceration, and reddish-brown scales indicative of hyperkeratosis. The lesions are usually found in skin folds, and also commonly present in the interdigital regions in hands and feet. Symptoms include reddish-brown scaly patches, itching, pain if irritated, skin shedding, blisters, softening and whitening of the skin, foul odor, and thickening and yellowing of the toenails.<unk>  develops when Corynebacterium minitissium infiltrates the stratum corneum and proliferate. Hyperkeratosis leads to the formation of reddish-brown lesions characteristic of<unk> . Microscopic pathology of<unk> s includes thickening of stratum corneum, decreased electron density around intracellular bacteria and those in direct contact with the cell wall, and widening of intracelluar space, allowing bacterial invasion, and separation of the horny cells.<unk>  is most commonly found in women over 40 years old, in individuals living in humid and tropical/subtropical climates, and in military personnel. Risk factors for<unk>  include individual and environmental conditions predisposing bacterial infection and proliferation. This includes overweight and obesity, diabetes, immunocompromise, and hyperhidrosis.<unk>  must be differentiated from other dermatological conditions that present with reddish-brown scales and itching, as well as other diseases resulting from corynebacteria infection. Diagnostic laboratory tests performed for suspected<unk>  include those that confirm a Corynebacterium minitissimum infection. The most common laboratory test is a Wood's lamp examination; coral-red fluorescence is indicative of Corynebacterium minitissimum. The mainstay of<unk>  medical therapy is topical and systemic antibiotic therapy. The primary antibiotics used for local and widespread infection include fusidic acid, clindamycin, clarithromycin, and erythromycin, respectively. Additionally, there are studies that display efficacy of systemic administration of tetracycline and chloramphenicol. There is evidence that fusidic acid therapy is more effective than topical clarithromycin and systemic erythromycin, but may be indicated less due to poorer efficiency and patient compliance. Administration of chloramphenicol is limited due to its suppression of bone marrow and heightening risk of developing neutropenia, agranulocytosis and aplastic anaemia. Effective measures of preventing<unk>  are preventative of Corynebacterium minutissimum infection and proliferation. Secondary prevention of<unk>  involves prophylactic use of antibacterial soap on the previously affected region.
Erythrasma
Icthyosis
Xanthelasma
Ulerythema
Onychophosis
Melasma
Retinitis punctata albescens
Ichthyosis