Causes can be as simple as trauma or infection. They can also be rheumatoid arthritis, endocarditis or athlerosclerotic vascular disease. The most common cause/complaint is Gout.
Gout can be so excruciating at times that even the weight of a bed sheet is unbearable.
Toe pain and swelling
Pedal edema
Leg pain
Ankle pain and swelling
Leg swelling
Inner bone pain
Wrist and hand pain
Palmar erythema