<unk>  is a zoonotic disease, humans are infected by the bites from parasites such as fleas, lice, mites, and ticks or by the inoculation of infectious fluids or feces from the parasites into the skin. The incubation period of<unk>  fever varies from one to two weeks. Following transmission, rickettsia are ingested by macrophages and polymorphonuclear cells. The major pathology is caused by a vasculitis and its complications. This process may cause result in occlusion of blood vessels and initiates inflammatory response (aggregation of leukocytes, macrophages, and platelets) resulting in small nodules. This vasculitic process causes destruction of the endothelial cells and leakage of the blood leading to volume depletion with subsequent hypovolemia and decreased tissue perfusion and, possibly organ failure.
Typhus pathophysiology
Foot-and-mouth disease pathophysiology
Strep throat pathophysiology
Tularemia pathophysiology
Cellulitis pathophysiology
Hand-foot-and-mouth disease pathophysiology
Trench fever pathophysiology
Pharyngitis pathophysiology