<unk>  (TAK-475) is a cholesterol-lowering drug. Unlike statins which inhibit HMG-CoA reductase,<unk>  metabolites inhibit squalene synthase which is further downstream in the synthesis of cholesterol. It is hoped that side effects can be reduced by not disturbing the mevalonate pathway which is important for other biochemical molecules besides cholesterol.
However, there is increasing evidence that statins (which inhibit the mevalonate pathway) may be clinically useful because they affect these other molecules (including protein prenylation) Greenwood et al., 2006. It remains to be seen how effective<unk>  will be.
On March 28, 2008, Takeda halted further development of<unk> .
Lapaquistat
Patch Adams
Lovemap
Bunsen burner
Pantopaque
Sixten Franzén
Side stitch
Stubs iron wire gauge