Elevated levels of D-dimer signify the activation of hemostasis and fibrinolytic pathway.  It is a non-specific marker that has been widely implicated in acute venous thromboembolism (VTE).  However, D-dimer levels are also increased in patients with other conditions, such as cancer, pregnancy, infections, trauma, and recent surgery.
High D-dimer causes
Deep vein thrombosis causes
Cholesterol emboli syndrome causes
Lymphedema causes
Aortic dissection causes
Varicose veins causes
Angiodysplasia causes
Anasarca causes