Clinical signs of neurosyphilis (i.e., cranial nerve dysfunction, meningitis, stroke, acute or chronic altered mental status, loss of vibration sense, and auditory or ophthalmic abnormalities) warrant further investigation and treatment for neurosyphilis.
Laboratory testing is helpful in supporting the diagnosis of neurosyphilis; however, no single test can be used to diagnose neurosyphilis in all instances.
Cerebrospinal fluid <unk>  abnormalities are common in persons with early<unk> .
Diagnosed by finding high numbers of leukocytes in the<unk>  or abnormally high protein concentration in the setting of<unk>  infection.
VDRL in cerebrospinal fluid <unk> -VDRL), which is highly specific but insensitive, is the standard serologic test for<unk> . Although some advocate using the FTA-ABS test to improve sensitivity.
When reactive in the absence of substantial contamination of<unk>  with blood, it is considered diagnostic of neurosyphilis; however in early<unk> , it can be of unknown prognostic significance.
Most other tests are both insensitive and nonspecific and must be interpreted in relation to other test results and the clinical assessment. Therefore, the laboratory diagnosis of neurosyphilis usually depends on various combinations of reactive serologic test results,<unk>  cell count or protein, and a reactive<unk> -VDRL with or without clinical manifestations.
Syphilis/CSF analysis
Neurosyphilis MRI
Syphilis/Serology
Neurosyphilis CT scan
Adrenoleukodystrophy CT
Syphilis/Laboratory tests
Japanese encephalitis MRI
St. Louis encephalitis MRI