<unk>  is a major health problem involving 43.9% (43.4 million) of the male and female population in the United States. The disease incidence is increased by age. The most common involved age group is 80 years and older. White females and African-American males have the highest incidence among the other races. The incidence of lifetime osteoporotic fracture, as the most important outcome of<unk> , is approximately one out of every two women and also one in four men over the age of 50 worldwide. More than 1.5 million fractures occurred secondary to<unk>  per year; among which are 300,000 hip fracture, 700,000 vertebral fracture, 250,000 wrist fracture, and more than 300,000 other bones fractures. Major epidemiological studies conducted in the US, estimated that 10.3% (10.2 million) of people older than 50 years are affected with<unk> .<unk>  affects about 75 million people in Europe, USA, and Japan.
Osteoporosis epidemiology and demographics
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