<unk>  <unk>  in British English) is among the most common sexually transmitted diseases in the world. In the United States,<unk>  is the second most common STD (after chlamydia).
Neisseria<unk> e is a species of Gram-negative, coffee bean-shaped diplococci bacteria responsible for the sexually transmitted infection<unk> .<unk>  can infect mucus-secreting epithelial cells in both men and women.
The first place this bacterium infects is usually the columnar epithelium of the urethra and endocervix. Non-genital sites in which this bacterium thrives include the rectum, the oropharynx, and the conjunctivae of the eyes. 
Established routes of transmission of Neisseria<unk> e include vaginal and rectal intercourse, fellatio, cunnilingus, and perinatal.
The main pathogenicity of the Neisseria<unk>  stems from the ability of the surface pili to attach to the surface of the urethra, fallopian tubes, and endocervix.
In pregnancy,<unk> nococcus can be transmitted to the fetus at the time of delivery. 
Additionally, development of disseminated<unk> nococcal infection is the result of Neisserial organisms' dissemination to the blood.
Common risk factors in the development of<unk>  include sexual activity, multiple sex partners, previous history of sexually transmitted diseases, having a sexual partner with a past history of any sexually transmitted disease, and failure to use condoms during sex.
In 50 to 70% of women, the initial infection with Neisseria<unk>  may be asymptomatic. The most common complication of untreated<unk>  is pelvic inflammatory disease (PID), which may lead to increased risks of ectopic pregnancy. If left untreated, ectopic pregnancy can be life-threatening to the mother.
In men,<unk>  usually results in urethritis, which may result in dysuria. If left untreated,<unk>  may result in inflammation of the epididymis (epididymitis), prostate gland (prostatitis), and urethral structure. Disseminated<unk> nococcal infection (DGI) occurs in about 0.5 to 3% of patients, commonly following asymptomatic mucosal infection in both sexes.
Empiric treatment for<unk>  is usually initiated prior to receipt of laboratory results. Nucleic acid amplification tests (NAATs) are the test of choice in all individuals who present with urogenital symptoms.
The mainstay of therapy for<unk> nococcal infections is antimicrobial therapy.<unk>  treatment is complicated by the ability of N.<unk> e to develop resistance to antimicrobials; accordingly, a combination therapy with azithromycin and a cephalosporin is used to improve treatment efficacy and potentially slow the emergence and spread of antibiotic resistance.
Effective measures for the primary prevention of<unk>  infection include practicing abstinence, avoiding high-risk sexual behaviors (e.g., having unprotected sex or multiple sexual partners), and using latex condoms. Measure for the secondary prevention of<unk>  infection include early detection, treatment of sexual partners, and treatment of other sexually transmitted infections (e.g., chlamydia).
Gonorrhea
Leukorrhea
Rhinorrhea
Atrophic vaginitis
Bacterial vaginosis
Trichiasis
Dysentery
Trichomoniasis