<unk>  is a chronic progressive neurological disease that affects both upper and lower motor neurons. It presents with muscle spasms, fasciculation, weakness and which could ultimately lead to muscles paralysis.<unk>  is diagnosed clinically, however additional testing with electromyography to confirm muscle denervation. Laboratory tests might be required to rule out other reversible causes of weakness.<unk>  has a poor prognosis with death usually due to respiratory complications with a median survival of 3-5 years.<unk>  is managed by a multidisciplinary care setting with fewer disease modifying agents to date.
Amyotrophic lateral sclerosis
Multiple system atrophy
Adrenomyeloneuropathy
Lambert-Eaton myasthenic syndrome
Paraneoplastic cerebellar degeneration
Tropical spastic paraparesis
Motor neuron disease
Charcot-Marie-Tooth Syndrome