<unk> s <unk>  is a severe bone disease that affects the<unk> s, including the maxilla and the mandible.<unk>  bone (osteo-) damage and death (-necrosis) occurs as a result of reduced local blood supply (ischemia). The condition is thus included in the general category of ischemic or avascular<unk>  (literally "dead bone from poor blood flow.").  Various forms of<unk>  have been described over the last 160 years, and a number of causes have been suggested in the literature. In recent years, an increased incidence of<unk>  has been associated with the use of high dosages of bisphosphonates, required by some cancer treatment regimens, especially when the patient undergoes subsequent dental procedures. The possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat osteoporosis, remains uncertain.  Various treatment options have been explored, however severe cases of<unk>  still require surgical removal of the affected bone. Careful anamnesis (patient history) and assessement of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered.
Osteonecrosis of the jaw
Osteomyelitis
Bone infarction
Osteolysis
Synarthrosis
Bone metastasis
Osteopetrosis
Vertebral osteomyelitis