<unk>  or<unk> iladelphia translocation is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia (CML).  It is due to a reciprocal translocation designated as t(9;22)(q34;q11), which means an exchange of genetic material between region q34 of chromosome 9 and region q11 of chromosome 22. The presence of this translocation is a highly sensitive test for CML, since 95% of people with CML have this abnormality (The remainder have either a cryptic translocation that is invisible on G-banded chromosome preparations, or a variant translocation involving another chromosome or chromosomes as well as the long arm of chromosomes 9 and 22). However, the presence of the<unk> iladelphia <unk>  chromosome is not sufficient to diagnose CML, since it is also found in acute lymphoblastic leukemia (ALL, 25–30% in adult and 2–10% in pediatric cases) and occasionally in acute myelogenous leukemia (AML).
Philadelphia chromosome
72F fusion protein
T-cell prolymphocytic leukemia x ray
Chromosome 2p16.1-p15 deletion syndrome
Partial monosomy 13q
Myeloma protein
Heterochromatin
ZAP70 deficiency