<unk> (vaginal) is a hormone that is FDA approved for the treatment of atrophic vaginitis and kraurosis vulvae and severe dyspareunia. There is a Black Box Warning for this drug as shown here.  Common adverse reactions include [edema]], vasodilatation, chloasma, hirsutism, injection site reaction, pruritus, weight change, abdominal pain, bloating, diarrhea, flatulence, nausea, vomiting, backache, leg cramp, asthenia, headache, migraine, depression, disturbance in mood, disorder of menstruation, pain of breast, vaginitis, withdrawal bleeding, cough, and pharyngitis.
Conjugated estrogens 
Esterified estrogens
Antiandrogen
Sex steroid
Selective estrogen receptor modulator
Conjugated Estrogens Synthetic B
Steroid hormone
Oral contraceptive