The<unk>  virus is categorized as a Lyssavirus. The molecular biology of<unk>  consists of bullet shaped virus with helical symmetry that has a length of approximately 180 nm.<unk>  typically has its greatest effect on the brain.<unk>  is typically defined by encephalitis and myelitis. Various carnivorous animal species have been identified as the source of<unk>  virus (RV). In Africa and Asia, domestic dogs are the main reservoirs of<unk>  virus infection. Whereas, in the United States, racoons, foxes, skunks, coyotes, possums and bats are understood to be responsible for the spread of<unk>  virus.The neuromuscular junction is the major site of entry into neurons. RV infects peripheral nerves and then reaches the central nervous system (CNS) via retrograde axonal transport. The primary mechanism involved in the neuroinvasion of RV is trans-synaptic neuronal spread. RV infects neurons and leads to the degeneration of the neuronal processes by disrupting cytoskeletal integrity. Histopathologic evidence of<unk>  encephalomyelitis (inflammation) in brain tissue and meninges includes, mononuclear infiltration, perivascular cuffing of lymphocytes or polymorphonuclear cells, lymphocytic foci, Babes nodules consisting of glial cells and Negri bodies.
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