A<unk>  is a normal gene that can become an<unk>  due to mutations or increased expression. The resultant<unk> in may be termed as oncoprotein.<unk> s code for<unk> ins that help to regulate cell growth and differentiation.<unk> s are often involved in signal transduction and execution of mitogenic signals, usually through their<unk> in products. Upon activation, a<unk>  (or its product) becomes a tumor-inducing agent, an<unk> . Examples of<unk> s include RAS, WNT, MYC, ERK, and TRK. The MYC gene is implicated in Burkitt's Lymphoma, which starts when a chromosomal translocation moves an enhancer sequence within the vicinity of the MYC gene. The MYC gene codes for widely used transcription factors. When the enhancer sequence is wrongly placed, these transcription factors are produced at much higher rates. Another example of an<unk>  is the Bcr-Abl gene found on the Philadelphia Chromosome, a piece of genetic material seen in Chronic Myelogenous Leukemia caused by the translocation of pieces from chromosomes 9 and 22. Bcr-Abl codes for a receptor tyrosine kinase, which is constitutively active, leading to uncontrolled cell proliferation. (More information about the Philadelphia Chromosome below)
Proto-oncogene
Oncogene
Tumor suppressor gene
Tumor antigen
Transposon
Receptor tyrosine kinase
Short tandem repeat
Small GTPase