Syphilis is named as the "Great Imitator"  because the symptomatology and physical exam findings of syphilis in different stages mimicks large variety of other diseases. Syphilis must be differentiated from other common diseases that cause rash such as measles, rubella, Kawasaki disease , and mononucleosis. Syphilis also has overlapping symptoms with the other genital infections such as chancroid, condyloma acuminata, genital warts, herpes simplex, and herpes zoster.
Syphilis differential diagnosis
Neurosyphilis differential diagnosis
Lyme disease differential diagnosis
Babesiosis differential diagnosis
Tularemia differential diagnosis
Psittacosis differential diagnosis
Roseola differential diagnosis
Typhus differential diagnosis