The underlying pathophysiology of<unk><unk>  is dopamine depletion. Reduced number of dopaminergic neurons lead to increased inhibition of thalamus and as a result, decrease excitation of brain cortex, causing bradykinesia. pathologic hallmark of PD is lewy bodies which are round cytoplasmic eosinophilic inclusions. This<unk>  can have so many triggers ( Protein misfolding, Defective proteolysis, Mitochondrial dysfunction, Oxidative stress, Iron metabolism and Immunologic and inflammatory mechanisms) but the main etiology of neuronal degeneration is either apoptosis or necrosis.
Parkinson's disease pathophysiology
Lesch-Nyhan syndrome pathophysiology
Dementia pathophysiology
Multiple sclerosis pathophysiology
Adrenoleukodystrophy pathophysiology
Amyotrophic lateral sclerosis pathophysiology
Schizophrenia pathophysiology
Amnesia pathophysiology