<unk>  congenital adrenal hyperplasia results from defects in the steps from cholesterol to pregnenolone. The adrenals are large and filled with<unk>  globules derived from cholesterol. Life-threatening mineralocorticoid and glucocorticoid deficiency becomes apparent in infancy or early childhood. Sex steroid production is greatly impaired. XY infants (genetic males) are severely undervirilized so that the external genitalia at birth are female (normal or slightly virilized). XX infants have normal female anatomy and if their mineralocorticoid and glucocorticoid deficiencies are treated will often undergo spontaneous puberty.<unk>  storage damages the adrenals and eventually the gonads as well, so that all persons with this condition have so far been infertile.
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21-hydroxylase deficiency pathophysiology
Congenital adrenal hyperplasia medical therapy
Acromegaly pathophysiology
Secondary adrenal insufficiency causes
Hypophyseal hypertrophy in pregnancy
Multiple endocrine neoplasia type 2 pathophysiology
Multiple endocrine neoplasia type 1 pathophysiology