In-stent<unk>  (ISR) is the most frequent late complication of<unk>  implantation and occurs when there is a reoccurrence of<unk> sis in a lesion that was previously treated with a<unk> .  In<unk><unk>  results from exaggerated neointimal formation.  The lesion is primarily composed of smooth muscle cells and extracellular matrix.  Intravascular ultrasound studies demonstrate that in<unk><unk>  is not due to extrinsic compression of the<unk>  by scar tissue (i.e. there is not compression of the<unk> .
PCI in the patient with in stent restenosis
PCI in the patient at risk of bleeding
PCI in the patient with severely depressed ventricular function
PCI in the angulated or tortuous lesion
PCI in the patient with refractory ventricular arrhythmia
Antiplatelet therapy to support PCI
Coronary artery bypass surgery after failed PCI
PCI in the long lesion