<unk>  (INN), also known as silybin (both from Silybum, the generic name of the plant from which it is extracted), is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of<unk> , isosilibinin, silicristin, silidianin and others.<unk>  itself is mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio.Both in vitro and animal research suggest that<unk>  has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins.<unk>  has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
Chemically modified<unk> ,<unk>  dihydrogen disuccinate disodium (trade name Legalon SIL), a solution for injection, is currently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning.There is also clinical evidence for the use of<unk>  as a supportive element in alcoholic and child grade 'A' liver cirrhosis.
Silibinin
Dihydroartemisinin
Peruvoside
Gedocarnil
Delamanid
Dimetacrine
Pyritinol
Malathion