<unk>  is an antibiotic  that has been in use in Europe for about fifty years, and has proven to be very effective at combating biofilm infections.<unk>  was shown to cause a decrease in the biofilm density of P. aeruginosa infections, which would allow access to the infection by the immune system in vivo. It was shown that<unk>  functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix; when Fe2+ and Zn2+ were reintroduced into the system, biofilm formation was reconstituted.  The activity of biofilm degradation is comparable to EDTA, but has a history of human use in clinical settings and therefore has a precedent with which to allow its use against “slimy” biofilm infections.
Nitroxoline
Calcium oxide
Nitrous oxide
Sodium nitrite
Squalene
Allyl chloride
Dihydroergotamine 
Naphazoline