<unk>  <unk>  is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of<unk>  may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic<unk>  is 39 years. Some people have a variant of the disorder, called attenuated<unk> , in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated<unk>  is 55 years.
In people with classic<unk> , the number of polyps increases with age, and hundreds to thousands of polyps can develop in the colon. Also of particular significance are noncancerous growths called desmoid tumors. These fibrous tumors usually occur in the tissue covering the intestines and may be provoked by surgery to remove the colon. Desmoid tumors tend to recur after they are surgically removed. In both classic<unk>  and its attenuated variant, benign and malignant tumors are sometimes found in other places in the body, including the duodenum (a section of the small intestine), stomach, bones, skin, and other tissues.
Familial adenomatous polyposis
Hereditary nonpolyposis colorectal cancer
Peutz-Jeghers syndrome
Fabry's disease
Cretinism
Ataxia telangiectasia
Neurofibromatosis type 1
Pickering syndrome