<unk>  (singular is<unk>  are stacks of red blood cells formed because of the unique discoid shape of these cells in vertebrate body. The flat surface of the discoid RBCs give them a large surface area to make contact and stick to each other forming<unk> . They occur when the plasma protein concentration is high, and because of them the ESR (erythrocyte sedimentation rate) is also increased. Conditions which do this include infections, inflammatory and connective tissue disorders, and cancers. It also occurs in diabetics and is one of the causative factors for microvascular occlusion in diabetic retinopathy.
1.<unk>  refers to the stacking of RBC
2. The presence of acute phase proteins particularly fibrinogen interacts with sialic acid on the surface of RBC and allows the formation of<unk> 
3. Anaemia by altering the ratio of RBC to plasma increases<unk>  formation and accelerates sedimentation
4.<unk>  formation is retarded by albumin proteins
Rouleaux
Stereocenter
Wart
Chilblain
Colextran
Lovemap
Ancrod
Sixten Franzén