Cyclin-dependent kinase inhibitor 2A (melanoma,<unk>  inhibits CDK4), also known as CDKN2A, is a human gene.
This gene generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM2, a protein responsible for the degradation of p53 . In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.<unk> is a tumour suppressor gene. Mutations in<unk> increase the risk of developing a variety of cancers, notably melanoma.<unk> is an important gene in regulating the cell cycle.
Recent research on the<unk> gene, published in Nature in September 2006, indicates that its increased expression as organisms age reduces the proliferation of stem cells.  This reduction in the division and production of stem cells protects against cancer while increasing the risks associated with cellular senescence.
The<unk> gene has an alternative reading frame (ARF) that encodes the<unk> ARF protein. this is involved in stabilising P53 and is positively regulated by E2F.<unk> NK4a is a major product of the CDKN2A locus. Its alternate reading frame product is p14ARF.<unk> NK4a regulates the cell cycle by binding and deactivating various cyclin-CDKcomplexes. A study published in 2007 in the New England Journal of medicine established that there is a strong association between polymorphisms on chromosome 9p21.3 (SNP, rs1333049) and coronary artery disease. This region codes for the INK4 proteins<unk> NK4a and p15INK4b. The corresponding genes are CDKN2A and CDKN2B. The proteins may inhibit cell growth induced by Transforming Growth Factor-beta.
P16 
APC 
P53 
TP53 
SMAS
XMC
PCNA
ErbB