<unk>  is a prognostic indicator based on observations by<unk> man J. Zimmerman that drug-induced hepatocellular injury with jaundice is a grave illness, with an estimated mortality rate of 10 to 50 percent.<unk>  is essentially a translation of<unk>  Zimmerman’s observation that pure hepatocellular injury sufficient to cause<unk> perbilirubinemia is an ominous indicator of the potential for a drug to cause serious liver injury. Thus, a finding of ALT elevation, usually substantial, seen concurrently with bilirubin >2xULN, identifies a drug likely to cause severe DILI (fatal or requiring transplant) at a rate roughly 1/10 the rate of<unk>  cases.
Hy's law
Cassie's law
Boyle's law
Planck's law
Weber–Fechner law
Enthesis
Theory of relativity
Naegele's rule