In biology,<unk>  <unk>  is a class of antibody (or<unk> isotype") that has only been found in mammals. It plays an important role in allergy, and<unk> specially associated with type 1 hypersensitivity.<unk>  has also been implicated in immune system responses to most parasitic worms like Schistosoma mansoni, Trichinella spiralis, and Fasciola hepatica, and may be important during immune defense against certain protozoan parasites such as Plasmodium falciparum.
Although<unk>  is typically the least abundant isotype - blood serum<unk>  levels in a normal ("non-atopic") individual are ~75 ng/ml, compared to 10 mg/ml for the IgGs (the isotypes responsible for most of the classical adaptive immune response) - it is capable of triggering the most powerful immune reactions.<unk>  was discovered in 1966 by the Japanese scientist Kimishige Ishizaka.
Immunoglobulin E
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunoglobulin D
Gamma globulin
Immunoglobulin heavy chain
Beta globulins