<unk>  illness is associated with a 5 to 13 fold increased incidence of a patent foramen ovale. The risk increases with an increase in defect size.  Device closure can be considered in divers with unexplained<unk>  illness, especially those who wish to continue diving . The number of ischemic brain lesions were twice as common among patients with a patent foramen ovale than in those without it.
Patent foramen ovale and decompression sickness
Patent foramen ovale and stroke
Atrial fibrillation acute myocardial infarction
Atrial fibrillation hypertrophic cardiomyopathy
Atrial fibrillation hyperthyroidism
Patent foramen ovale and migraine
Unstable angina / non ST elevation myocardial infarction and diabetes mellitus
Congestive heart failure and obstructive sleep apnea