<unk>  is a complement system dysregulatory disorder resulting in abnormal activation of the alternative pathway.<unk>  includes<unk>  glomerulonephritis <unk> GN) and dense deposit disease (DDD).  Both,<unk> GN and dense deposit disease are characterized by marked by<unk>  deposition along the capillary loop, the basement membrane, and the mesangium. Identification of<unk>  deposits without any concomitant immunoglobulin deposition is characteristic for diagnosing<unk> . The activation of the alternative pathway of the complement system can be either due to inherited, or acquired defects of the complement system. Gene mutations are the most common inherited causes while autoimmune disorders are responsible for acquired glomerulopathy.
C3 glomerulopathy
C4 glomerulopathy
Membranous glomerulonephritis
Membranoproliferative glomerulonephritis
ANCA associated vasculitis
Mesangial proliferative glomerulonephritis
Membranous nephritis
Endocapillary proliferative glomerulonephritis