The incidence of<unk><unk>  is approximately 7-23 new cases per year. The prevalence of<unk><unk>  is approximately 70-320 per million and increasing since 20th century. The age of onset in<unk><unk>  follows a bimodal distribution. The early type (before age of 50) is female predominant and the late type (after age of 60) is male predominant. Between the age of 50-60 there is no significant different between male and female. Some studies demonstrated that the incidence, prevalence and the severity of this disease is higher in African/Americans.
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