<unk>  is a disorder in which the  proximal tubular function of the kidney is impaired, resulting in decreased reabsorption of electrolytes and nutrients back into the bloodstream. Compounds involved include glucose, amino acids, uric acid, phosphate, and bicarbonate.
The reduced reabsorption of bicarbonate results in type 2 or proximal renal tubular acidosis, which may in some cases exist on its own, or more usually in combination with the<unk> .
In many cases, the disease is developed in the context of  multi-system genetic diseases(e.g Cystinosis, Galactosemia). And in many others, high exposure to toxic substances(e.g heavy metals, drugs) is discovered as the main risk factor. The disease can also develop as a consequence of other acquired diseases(e.g multiple myeloma, PNH).
Patients mainly present with dehydration, growth failure, rickets(children) and osteomalacia(adults).
It is named after Guido<unk> , a Swiss pediatrician; this may be a misnomer since<unk>  himself never identified it as a syndrome.
It should not be confused with<unk>  anemia, a separate disease.
Fanconi syndrome
Treacher Collins syndrome
McLeod syndrome
Rotor syndrome
Danon disease
Tome-Brune-Fardeau syndrome
Zunich-Kaye syndrome
Singleton-Merten syndrome