<unk> (oral) is a ergot alkaloid, antimigraine and central nervous system agent that is FDA approved for the treatment of to abort or prevent vascular headache, e.g., migraine, migraine variants or so-called “histaminic cephalalgia”. There is a Black Box Warning for this drug as shown here.  Common adverse reactions include pruritus, nausea and vomiting, muscle weakness, numbness, paresthesia, visual disturbance and vertigo.
Ergotamine and caffeine 
Isometheptene, caffeine and acetaminophen
Hydrocodone bitartrate and Homatropine methylbromide
Diphenoxylate hydrochloride and atropine sulfate
Netupitant and palonosetron
Nadolol and bendroflumethiazide
Hydrocodone bitartrate and acetaminophen
Brompheniramine maleate and Pseudoephedrine hydrochloride