<unk> <unk>  or<unk>  is a cancer of<unk>  cells, a type of white<unk> lood cell responsible for producing antibodies.<unk>  may<unk> e classified<unk> ased on location into nodal and extranodal disease and<unk> ased on molecular, genetic, and immunohistochemical features into more than 20 subgroups.<unk>  may<unk> e classified into 2 subtypes<unk> ased on gene expression profiles. The progression to<unk>  involves the microRNAs (miRNAs). On microscopic histopathological analysis,<unk>  can<unk> e divided into three variants: centroblastic, immunoblastic, and anaplastic. There are no established causes for<unk> .<unk>  is the most common type of non-Hodgkin lymphoma among adults, with an annual incidence of 7–8 cases per 100,000 people per year. This cancer occurs primarily in older individuals, with a median age of diagnosis at approximately 70 years of age, though it can also occur in children and young adults in rare cases. The most potent risk factor in the development of<unk>  is immunodeficiency.<unk>  must<unk> e differentiated from other diseases such as follicular lymphoma, Mucosa-Associated Lymphatic Tissue lymphoma(MALT), small cell lymphocytic lymphoma, and Mantle cell lymphoma (MCL). The prognosis of<unk>  depends on the stage of the disease.<unk>  is associated with a 5 year survival rate ranging from 70% to more than 90% among children. According to the Lugano classification, there are four stages of<unk> <unk> ased on the number of nodes involved and extranodal status. The most common symptoms of<unk>  include a rapidly enlarging, non-painful mass that may<unk> e located in neck, groin or abdomen. The less common symptoms of<unk>  include fever, weight loss and drenching night sweats. Common physical examination findings of<unk>  include a non tender mass which can arise in virtually any part of the<unk> ody. Laboratory tests of<unk>  include complete<unk> lood count,<unk> lood chemistry studies, flow cytometry, immunohistochemistry, cytology, genetic testing, and immunophenotyping. CT scan, MRI, and PET may<unk> e helpful in the diagnosis of<unk> . Lymph node or extranodal tissue<unk> iopsy is diagnostic of<unk> <unk>  cell lymphoma. Other diagnostic studies for<unk>  include laparoscopy, laparotomy, and<unk> one marrow aspiration and<unk> iopsy. The optimal therapy for<unk>  depends on the stage at diagnosis. The predominant therapy for<unk>  is chemotherapy. Adjunctive radiotherapy may<unk> e required. Active areas of research include genetic studies to assess the genetic role in<unk>  and novel therapeutic regimens that evaluate the efficacy and safety of novel regimens in in newly diagnosed<unk> .
Diffuse large B cell lymphoma
Anaplastic large cell lymphoma
Follicular lymphoma
AIDS-related lymphoma
Nodal marginal zone lymphoma
Mantle cell lymphoma
B-cell lymphoma
Small cell lymphoma