<unk>  is a PEGylated uric acid specific enzyme that is FDA approved for the treatment of chronic gout in adult patients refractory to conventional therapy. There is a Black Box Warning for this drug as shown here.  Common adverse reactions include gout flares, infusion reactions, nausea, contusion or ecchymosis, nasopharyngitis, constipation, chest pain, anaphylaxis and vomiting.
Pegloticase
Cerliponase alfa
Alglucosidase alfa
Peginesatide
Pyritinol
Dictyostelid
Poractant Alfa
Hydroxyethyl starch