<unk>  is the presence of high amount of heavy globulins (e.g. IgM)  in the bloodstream which thicken or gel on exposure to cold. Cryoglobulins are circulating immunoglobulins or proteins that become insoluble at less than 4 degrees Celsius. The reaction is reversible; redissolution occurs at 37 degrees Celsius.  Such proteins are called cryoglobulins.<unk>  can lead to a medium-sized vessel vasculitis due to vascular deposition of circulating immune complexes.  This leads to the triad of palpable purpura, arthralgias and peripheral neuropathy.  The relationship of cryoglobulins and hepatitis C infection as well as B cell neoplasia provides an interesting link between infection, autoimmune disease and lymphoproliferative disorders.
Cryoglobulinemia
Hemoglobinuria
Trimethylaminuria
Lipiduria
Xanthinuria
Beeturia
Proteinuria
Non immune hemolytic anemia