The<unk> , also called Paterson-Brown-Kelly syndrome or sideropenic dysphagia is a disorder linked to severe, long-term iron deficiency anemia, which leads to dysphagia, glossitis and esophageal webs. The disease is named after two American physicians Henry Stanley<unk> , and Porter Paisley<unk> . It is also called "Kelly-Paterson syndrome", named after two British otolaryngologists, Adam Brown-Kelly and Donald Ross Paterson. The exact pathogenesis of<unk>  is not fully understood. It is postulated that<unk>  results from iron deficiency. Other possible factors include malnutrition, genetic predisposition and autoimmune disorders. On gross pathology, esophageal web and esophageal strictures are characteristic findings of<unk> . On microscopic histopathological analysis,<unk>  presents with epithelial atrophy, chronic submucosal inflammation and epithelial atypia or dysplasia (in advanced cases). There are no established risk factors for<unk> . However, chronic irritation of the esophagus may predispose to an increased risk of developing esophageal webs or strictures.<unk>  is a rare disease and the data pertaining to its incidence and prevalence is not evidently available. Overall improvement in nutritional status with better medical care has markedly reduced the number of cases of<unk> . Common complications of<unk>  include hypopharyngeal cancer, esophageal cancer and malignant lesions of oral mucosa.<unk>  must be differentiated from other diseases that cause dysphagia such as reflux esophagitis, esophageal carcinoma, systemic sclerosis, esophageal spasm, pseudoachalasia, stroke, esophageal candidiasis, Zenker's diverticulum and Chagas disease. Physical examination of patients with<unk>  is usually remarkable for glossitis, esophageal webs or strictures, and dysphagia. Laboratory findings consistent with the diagnosis of<unk>  include presence of iron deficiency anemia. The diagnosis of<unk>  is made in the presence of iron-deficiency anemia with esophageal webs, dysphagia and glossitis. An x-ray (barium esophagogram) is the best initial imaging study in a patient suspected with<unk> . Other imaging studies include a videofluoroscopy or an esophagogastroduodenoscopy to visualise the esophageal webs. The mainstay of treatment for<unk>  is aimed at correcting iron deficiency anemia. Effective measures for the prevention of<unk>  include good nutrition with adequate intake of iron rich foods and an upper gastrointestinal endoscopy every year to rule out malignant transformation.
Plummer-Vinson syndrome
Bloom syndrome
Swyer's syndrome
Mallory–Weiss syndrome
Mallory-Weiss syndrome
Zenker's diverticulum
Barrett's esophagus
Schnitzler syndrome