Menopause is natural amenorrhea that is happened without any pathological causes, but premature menopause/early menopause is caused by  pathological diseases in ovaries and other organs such as premature ovarian failure (Primary ovarian insufficiency, POI),  Adrenal insufficiency, type1 diabetes mellitus, autoimmune thyroid disease, Fanconi’s anemia,  and Congenital adrenal hyperplasia. Cardiovascular disease and osteoporosis are most important conditions associated with menopause. Women who had genetic disorders ( Fragile X syndrome, Turner’s syndrome)  more prone able to early menopause. The histopathological analysis include ovaries's cortex becomes thinner and it has fewer follicles and the medulla develops  fibrosis and scars. Decrease of ciliated cells of  Fallopian tubes and Uterus. And atrophy of  vaginal mucosal layer .
Menopause pathophysiology
Prostate cancer risk factors
Menopause causes
Polycystic ovary syndrome pathophysiology
Delayed puberty pathophysiology
Prostate cancer pathophysiology
Erectile dysfunction risk factors
Breast cancer pathophysiology