Normal hematopoiesis involves the production of blood cells, and this normal physiologic process is dysregulated in<unk><unk>  leukemia. The pathophysiology of<unk><unk>  leukemia involves multiple mechanisms, including altered signal transduction and autonomous proliferation, differentiation blockade, evasion of apoptosis, and self-renewal. The pathophysiology of<unk>  promyelocytic leukemia is most commonly due to a reciprocal translocation between chromosomes 15 and 17. The novel gene production causes a differentiation block in<unk>  cells. There are multiple different binding partners for the RARA gene, so multiple translocations can contribute to the pathogenesis of<unk>  promyelocytic leukemia.
Acute myeloid leukemia pathophysiology
Acute lymphoblastic leukemia pathophysiology
Chronic myelogenous leukemia pathophysiology
Myelodysplastic syndrome pathophysiology
Myelofibrosis pathophysiology
Chronic lymphocytic leukemia pathophysiology
Hairy cell leukemia pathophysiology
Myelodysplastic syndrome risk factors