<unk> <unk>  from<unk> <unk><unk><unk>  2 is a recently recognized form of<unk> , and it has already been established as a frequent form of systemic<unk>  in the United States, with predominant involvement of kidney and liver. The disease has a strong ethnic bias, affecting mainly Hispanics (particularly Mexicans). Additional ethnic groups prone to develop<unk> <unk>  from<unk> <unk><unk><unk>  2 include Punjabis (native to India and Pakistan), First Nations people in British Columbia, and Native Americans. Most patients are elderly who present with chronic renal insufficiency and bland urinary sediment. Proteinuria is variable, being absent altogether in about one third of patients. Liver involvement is frequently an incidental finding.<unk> <unk>  from<unk> <unk><unk><unk>  2 deposits shows a characteristic distribution: in the kidney, there is consistent involvement of cortical interstitium, whereas in the liver, there is a preferential involvement of periportal and pericentral vein regions. Concurrent renal disease is frequent, with diabetic nephropathy and IgA nephropathy being the most common. Patient survival is excellent, likely because of the rarity of cardiac involvement, whereas renal survival is guarded, with a median renal survival of 62 months in those without concurrent renal disease. There is currently no efficacious therapy for<unk> <unk>  from<unk> <unk><unk><unk>  2<unk> . Renal transplantation seems to be a reasonable treatment for patients with advanced renal failure, although the disease may recur in the allograft. The pathogenesis of<unk> <unk>  from<unk> <unk><unk><unk>  2<unk>  has not yet been elucidated. It could be a result of<unk> <unk><unk><unk>  2 overexpression by hepatocytes either constitutively (controlled by yet-uncharacterized genetic defects) or secondary to hepatocellular damage. It is critical not to misdiagnose<unk> <unk>  from<unk> <unk><unk><unk>  2<unk>  as Immunoglobulin light chain-derived<unk>  to avoid harmful chemotherapy..
Leucocyte cell-derived chemotaxin 2 related amyloidosis
Secondary amyloidosis
Beta-2 microglobulin related amyloidosis
Gelsolin related amyloidosis
Transthyretin-related hereditary amyloidosis
Familial amyloidosis
Lysozyme amyloid related amyloidosis
Monoclonal gammopathy of undetermined significance