In immunology, the<unk>  is a type of local type III hypersensitivity<unk> .  Type III hypersensitivity<unk> s are immune complex mediated, and involve the deposition of an antigen/antibody complex mainly in the vascular walls, serosa (pleura, pericardium, synovium), and glomeruli.
The<unk>  was discovered by<unk>  in 1903.<unk>  repeatedly injected horse
serum subcutaneously into rabbits.  After four injections,
he found that there was edema and that the serum was absorbed slowly.  Further injections eventually led to gangrene.
The<unk>  involves the in situ formation of antigen/antibody complexes after the intradermal injection of an antigen.  If the animal/patient was previously sensitized (has circulating antibody), an<unk>  occurs.  This manifests as local vasculitis due to deposition of immune complexes in dermal blood vessels.  Activation of complement and recruitment of PMNs ensue resulting in an inflammatory response.<unk> s have been infrequently reported after vaccination against
diphtheria and tetanus.  To quote from the CDC:<unk> s (type III hypersensitivity<unk> s) are
rarely reported after vaccination and can occur after tetanus
toxoid–containing or diphtheria toxoid–containing vaccines.  An<unk>  is a local vasculitis associated with deposition of
immune complexes and activation of complement. Immune
complexes form in the setting of high local concentration of
vaccine antigens and high circulating antibody concentration.<unk> s are characterized by
severe pain, swelling, induration, edema, hemorrhage, and
occasionally by necrosis. These symptoms and signs usually
occur 4–12 hours after vaccination.....ACIP has recommended that
persons who experienced an<unk>  after a dose of
tetanus toxoid–containing vaccine should not receive Td more
frequently than every 10 years, even for tetanus prophylaxis as
part of wound management.
Arthus reaction
Palindromic rheumatism
Arthritis
Dactylitis
Radiosensitivity
Phantom pain
Injection fibrosis
Injection site reaction