The exact pathogenesis of Kawasaki disease is not fully understood. However, it is thought that Kawasaki disease is caused by either environmental, genetic, or viral causes. Kawasaki disease is defined as the systemic inflammation of the medium sized arteries and in multiple organs and tissues, which can lead to associated conditions such as hepatitis, interstitial pneumonitis, abdominal pain, vomiting, diarrhea, gallbladder hydrops, aseptic meningitis, irritability, myocarditis, pericarditis, valvulitis, pyuria, pancreatitis, and lymphadenopathy. On gross pathology, large or giant coronary artery aneurysms, thrombi containing aneurysms, decreases in luminal diameter, stenosis of the lumen and chronic inflamation are noted. On microscopic histopathological analysis of autopsied cases of Kawasaki disease, intracytoplasmic inclusion bodies are frequently observed in ciliated bronchial epithelial cells.
Kawasaki disease pathophysiology
Kawasaki disease diagnostic criteria
Kawasaki disease laboratory findings
Kawasaki disease risk factors
Group A streptococcal infection pathophysiology
Typhoid fever pathophysiology
Group B streptococcal infection pathophysiology
Kawasaki disease classification