On gross pathology, a plaque with an irregular border and erythematous or white skin lesion are characteristic findings of extramammary Paget's<unk> . On microscopic histopathological analysis, Paget's cells (large cells with abundant amphophilic or basophilic, finely granular cytoplasm, large centrally-located nucleus with prominent nucleolus) and signet ring cells are characteristic findings of extramammary Paget's<unk> . Extramammary Paget's<unk>  arises from keratinocytic stem cells or from apocrine gland ducts. Approximately 25% (range 9-32%) of the cases of extramammary Paget's<unk>  are associated with an underlying in situ or invasive neoplasm. The neoplasm most likely to be associated with extramammary Paget's<unk>  is an adnexal apocrine carcinoma, which usually represents infiltration of the deeper adnexa by epidermal Paget's cells.
Extramammary Paget's disease pathophysiology
Skin cancer pathophysiology
Basal cell carcinoma pathophysiology
Oral cancer pathophysiology
Extramammary Paget's disease differential diagnosis
Melanoma pathophysiology
Paget's disease of the breast pathophysiology
Extramammary Paget's disease other diagnostic studies