Large<unk>  carcinoma of the lung arises from the epithelial<unk> s of the lung, which are usually involved in the lining of the airways. The pathological irritation causes the mucus-secreting ciliated pseudostratified columnar respiratory epithelial<unk> s to be replaced by stratified squamous epithelium. Large<unk>  carcinoma of the lung has a peripheral location, and usually appears as a well-circumcised mass attached to the thoracic wall. Large<unk>  carcinoma of the lung is a rapidly growing cancer. The histologic subtype of large<unk>  neuroendocrine tumor is related with a more aggressive presentation. Genes involved in the pathogenesis of large<unk>  carcinoma of the lung, include: EGFR, LKB1, KRAS, HER2, and ALK. On gross pathology, large<unk>  carcinoma of the lung is characterized by well-defined borders, spherical morphology, homogeneous gray-white surface, and bulging appearance. On micropathology, large<unk>  carcinoma of the lung is characterized by the larger size of the anaplastic<unk> s, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin. On immunohistochemistry characteristic features of large<unk>  carcinoma of the lung, include: loss of staining with CK5/6, and positive immunoreactivity to EGFR, PDGFR-alpha, and c-kit.
Large cell carcinoma of the lung pathophysiology
Small cell carcinoma of the lung pathophysiology
Squamous cell carcinoma of the lung pathophysiology
Adenocarcinoma of the lung pathophysiology
Mesothelioma risk factors
Lung mass pathophysiology
Large cell carcinoma of the lung causes
Multiple pulmonary nodules causes