Subdural<unk>  is a medical emergency and requires prompt treatment. Treatment of subdural<unk>  requires a combined medical and surgical approach. Empiric antimicrobial therapy depends on the location of the infection (intracranial vs. spinal) and whether it was community-acquired or hospital-acquired. The preferred regimen for intracranial subdural<unk>  includes (vancomycin 30–45 mg/kg/day IV q8–12h for 3-4 weeks OR nafcillin 2 g IV q4h for 3-4 weeks OR oxacillin 2 g IV q4h for 3-4 weeks) AND (ceftriaxone 2 g IV q12h for 3-4 weeks OR cefotaxime 8–12 g/day IV q4–6h for 3-4 weeks) AND metronidazole 7.5 mg/kg IV q6h for 3-4 weeks. The preferred regimen for spinal subdural<unk>  includes (vancomycin 30–45 mg/kg/day IV q8–12h for 3-4 weeks OR nafcillin 2 g IV q4h for 3-4 weeks OR oxacillin 2 g IV q4h for 3-4 weeks). Duration of therapy is usually 3-4 weeks, but more prolonged therapy (total of 6-8 weeks) may be necessary among patients who develop complications of the disease, such as osteomyelitis.
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