<unk>  arises from endothelial cells, which are epithelial cells that normally lines the luminal surface of blood vessels and lymphatic vessels.<unk>  is mainly caused by an infection with Human herpes virus 8 (HHV-8), which is also known as<unk> -associated herpes virus <unk> HV). The main gene involved in the pathogenesis of<unk>  is ORF73 gene, which encodes the viral latency-associated nuclear antigen (LANA-1).<unk>  is commonly associated with acquired immune deficiency syndrome (AIDS). On gross pathology, reddish, violaceous, or bluish-black macules and patches are characteristic findings of<unk> . On microscopic histopathological analysis the presence of spindle cells with minimal nuclear atypia are characteristic findings of<unk> .<unk>  may be classified according to the clinical setting of the disease into five subtypes: Classic<unk> , African cutaneous<unk> , African lymphadenopathic<unk> , Iatrogenic<unk> , and AIDS-associated<unk> . The epidemiology of<unk>  sarcoma varies depending on its specific subtype. Before the AIDS epidemic,<unk>  was relatively rare. In the early epidemic of AIDS, the incidence of HIV-related<unk>  sarcoma significantly increased; however, antiretroviral therapy led to a decrease in the incidence of HIV-related<unk>  sarcoma. While endemic African<unk>  sarcoma is more common in African Bantu, classic<unk>  sarcoma is more prevalent in Middle Eastern countries particularly among males and individuals from Jewish descent.  The incidence of<unk>  sarcoma is markedly increased in renal transplant patients ranging from 0.5% to 5.3%.  Transplant-related<unk>  sarcoma occurs more commonly in individuals who have Jewish, Arabic, Mediterranean, African, or Caribbean ethnicity.  In the United States, the age-adjusted prevalence of<unk>  sarcoma is 8.1 per 100,000 in 2011. The most potent risk factor in the development of<unk>  is an immune deficiency state. There is no established system for the staging of<unk>  among immune competent patients. However, the staging of AIDS-associated<unk>  is based on the  AIDS Clinical Trials Group (ACTG) staging system. Symptoms of<unk>  include fever, abdominal pain, hematochezia, hemoptysis, and gradual development of red/violaceous macules and patches over the nose, legs, and feet. The optimal therapy for<unk>  depends on multiple factors. Management strategies varies depending on the specific variant of<unk> . Classic<unk>  management may range from no treatment to either radiotherapy, local therapeutic interventions, or surgical excision. Iatrogenic<unk>  management focuses on modifying immunosuppressive therapy in addition to local therapeutic interventions. Endemic<unk>  is primarily managed by systemic chemotherapy. However, there is no curative treatment for epidemic<unk> ; the mainstay management for such patients is HAART therapy which aims for the control of<unk>  progression. Local/regional therapy recommended for the management of<unk>  patients may include surgical excision, cryotherapy, and sclerotherapy.
Kaposi's sarcoma
Liposarcoma electrocardiogram
Ewing's sarcoma
Lymphangiosarcoma
Castleman's disease
BCG-oma
Rhabdomyosarcoma electrocardiogram
Angiosarcoma