Entry of the organism into bone is the first step in the development of<unk>  and occurs by three main mechanisms; hematogenous seeding, contiguous spread of infection to bone from adjacent soft tissue, and direct inoculation from trauma or orthopedic surgery (including prostheses).
Microbial and host factors contributing to the pathological process of the disease may vary from one patient to another. In children, the long bones are usually affected. Acute<unk>  almost invariably occurs in children. In adults, the vertebrae and the pelvis are most commonly affected, possibly due to the compromised host resistance as a result of debilitation, intravenous substance abuse, infectious root-canaled teeth, or other disease or drugs (e.g., immunosuppressive therapy).
Osteomyelitis pathophysiology
Vertebral osteomyelitis pathophysiology
Bursitis pathophysiology
Septic arthritis pathophysiology
Osteoarthritis pathophysiology
Osteochondroma pathophysiology
Ankylosing spondylitis pathophysiology
Osteoarthritis causes