<unk>  <unk> D) is a rare non-melanocytic intraepidermal skin lesion. It usually involves the epidermis, but occasionally extends into the underlying dermis. It has predilection for apocrine gland-bearing areas: mostly the perineum, vulva, axilla, scrotum and penis.<unk>  may be classified into two groups based on the origin of the<unk> 's cells.<unk>  may be classified into four subtypes based on site of origin and area affected. On gross pathology, plaque with an irregular border and erythematous or white lesion are characteristic findings of<unk> . On microscopic histopathological analysis, the presence of<unk> 's cells (large cells with abundant amphophilic or basophilic, finely granular cytoplasm and a large, centrally-located nucleus and prominent nucleolus) and signet ring cells are characteristic findings of<unk> .<unk>  is usually associated with adnexal apocrine carcinoma, which represents infiltration of the deeper adnexa by epidermal<unk>  cells. Neither the direct cause nor a prominent risk factor of<unk>  has been identified.<unk>  is rare and the exact incidence is unknown.<unk>  commonly affects individuals 50-60 years of age. Females are more commonly affected with the<unk>  than males. The female to male ratio is approximately 3-4.5 to 1. It usually affects individuals of the Caucasian race, but it may occur in other races. Symptoms of<unk>  include pruritis, vulvar pain, vulvar bleeding, and burning sensation. Biopsy is diagnostic of<unk> . Other diagnostic studies for<unk>  include fine needle aspirate and PAP smear. Treatment depends on the stage at diagnosis. Treatment often includes surgery and chemotherapy with either 5-fluorouracil, imiquimod, or combination of paclitaxel and trastuzumab.
Extramammary Paget's disease
Actinic keratosis
Mammary ductal carcinoma
Basal cell carcinoma
Inverted follicular keratosis
Disseminated superficial actinic porokeratosis
Congenital melanocytic nevus
Pyogenic granuloma