<unk>  is the presence of increased levels of macroglobulins in the circulating blood.
A plasma cell dyscrasia resembling leukemia with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete an immunoglobulin M monoclonal component. There is diffuse infiltration of bone marrow and also, in many cases, of the spleen, liver, or lymph nodes. The circulating macroglobulin produces symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence is in the sixth and seventh decades. (Dorland, 28th ed)
Macroglobulinemia
Familial erythrocytosis
POEMS syndrome
Hereditary elliptocytosis
Drug-induced agranulocytosis
Monoclonal gammopathy of undetermined significance
Familial amyloidosis
Hemophagocytic lymphohistiocytosis