The Signal Transducers and Activator of Transcription <unk> s regulate many aspects of cell growth, survival and differentiation.  The transcription factors of this family are activated by the Janus Kinase JAK and dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis, enhanced survival of tumors and immunosuppression. Knockout studies have provided evidence that<unk> s are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance.
STAT protein
MAP kinase kinase kinase
G protein
Janus kinase
Rho GTPase
GTPase activating protein
IC-26
Tumor necrosis factor receptor