Morton's neuroma is associated with symptomatic collapse of the transverse arch by perineural fibrosis around a plantar digital nerve of the foot due to chronic traction and increased pressure/compression on the interdigital nerve. It is located at the third intermetatarsal space most commonly (between third and fourth metatarsals), and sometimes second or fourth interspaces or bifurcation of the fourth plantar digital nerve. Gross pathological features of morton's neuroma include adherent fibrofatty tissue, small, firm, oval, yellowish-white, slowly growing, palpable nodule on skin (no discoloration of skin on the top of nodule) and </=2cm in size. Histopathological analysis is characterized by extensive fibrosis around and within the nerve, digital artery, thrombosis, epineural and endoneural arterial thickening/vascular hyalinization, and degenerated/demyelinated axons. Possible tissue pathologies associated with interdigital pain of morton's neuroma include perineural fibrosis, endoneural edema, neurofibromata, angioneurofibromata, local demyelination, and local vascular degeneration.
Morton's neuroma pathophysiology
Bell's palsy pathophysiology
Buerger's disease pathophysiology
Complex regional pain syndrome pathophysiology
Acoustic neuroma pathophysiology
Carpal tunnel syndrome pathophysiology
Complex regional pain syndrome epidemiology and demographics
Morton's neuroma other imaging findings