The term<unk> " was first used by Dr. William Brinton, an English physician, in 1854. Development of<unk>  is the result of genetic mutation in the CDH1 (E-cadherin) gene, that is responsible for intercellular adhesions. On gross pathology, a thick, rigid, and leather bottle-like stomach wall is a characteristic finding of<unk> . On microscopic histopathological analysis, atypical signet ring cells that diffusely infiltrate the stomach wall, submucosal fibrosis and thickening, and a minimal mucosal involvement are characteristic findings of<unk> .<unk>  usually affects individuals of the Asian race. The presence of metastasis is associated with a particularly poor prognosis among patients with<unk> .<unk>  is associated with a 5-year survival rate of approximately 10-20% in Japan. Total gastrectomy is recommended for the management of local disease and as a prophylactic surgery in patients with hereditary form of<unk> .
Linitis plastica
Pachyonychia congenita
Lichen striatus
Naevus Lipomatosus superficialis
Dens evaginatus
Erythroplasia of Queyrat
Trichostasis spinulosa
Epidermolysis bullosa