The pathogenesis of<unk>  nephropathy caused by phenacetin may be due to several reasons. Toxic metabolites of phenacetin cause capillary sclerosis in the renal medulla, which results in renal papillary necrosis, tubulointerstitial nephropathy and cortical atrophy. Renal ischemia and renal papillary necrosis may be result from the methemoglobinemia caused by phenacetin. Additionally, It has been reported that the concentration of phenacetin is higher at the papillary which is suggestive of direct damage to the renal papillary cells.  Although non-phenacetin<unk> s (such as NSAIDs, aspirin and acetaminophen) or their combinations have been reported in some studies as causes to<unk>  nephropathy, but there is insufficient evidence that suggests these drugs cause<unk>  nephropathy.
Analgesic nephropathy pathophysiology
Contrast induced nephropathy pathophysiology
Diabetic nephropathy pathophysiology
Renal papillary necrosis pathophysiology
Interstitial nephritis pathophysiology
Renal amyloidosis pathophysiology
Acute tubular necrosis pathophysiology
Renal artery stenosis pathophysiology