<unk>  disease is a defect in muscularis mucosa of gastrointestinal tract.<unk>  is classified into 2 depending upon the location of ulcer, gastric ulcer and duodenal ulcer. The most common cause of<unk>  disease is H.pylori infection which is acquired in childhood but presents in adulthood. Other causes of<unk>  disease are chronic use of NSAID, family history of<unk>  disease. Persistant use of NSAIDS or chronic infection with H.Pylori results in inflammation of antral mucosa and ultimately causes the ulcer. The most common symptoms of<unk>  disease include episodic epigastric pain, heartburn, loss of appettite, gastroesophageal reflux, waterbrash, hematemesis and melena. Common physical examination findings of<unk>  disease include epigastric tenderness, tachycardia. Endoscopy is the gold standard test for the diagnosis of the<unk>  disease. Treatment of helicobacter pylori with antimicrobial agents is indicated for patients with gastric or duodenal ulceration. Pharmacologic therapies for<unk>  disease due to H. pylori is either triple or quadruple pharmacologic agents that include a Proton<unk> mp inhibitors plus a combination of antimicrobial agents.
Peptic ulcer
Oral ulcer
Stress ulcer
Tropical ulcer
Gastrointestinal varices
Nosebleed
Chronic colestites
Venous ulcer