<unk>  (abbreviated<unk>  is a genetic disorder, in which seven genes (or some subset thereof) on chromosome 15 are missing or unexpressed (chromosome 15q partial deletion) on the paternal chromosome. It was first described in 1956 by Andrea<unk> , Heinrich<unk> , Alexis Labhart, Andrew Ziegler, and Guido Fanconi of Switzerland. The incidence of<unk>  is between 1 in 12,000 and 1 in 15,000 live births. The distinction of chromosome by parental origin is due to imprinting and<unk>  has the sister syndrome Angelman Syndrome that affects maternally imprinted genes in the region.<unk>  is characterized by hyperphagia and food preoccupations, as well as small stature and learning difficulties.
Traditionally,<unk>  was diagnosed by clinical presentation.  Currently, the syndrome is diagnosed through genetic testing, and is recommended for newborns with pronounced hypotonia. Early diagnosis of<unk>  allows for early intervention as well as the early prescription of growth hormone. Daily recombinant growth hormone (GH) injections  are indicated for children with<unk> .  GH supports linear growth and increased muscle mass, and may lessen food preoccupation and weight gain.
Prader-Willi syndrome
Bardet-Biedl syndrome
Beckwith-Wiedemann syndrome
Laron syndrome
Klippel-Trenaunay-Weber syndrome
Smith-Magenis syndrome
Joubert syndrome
13q deletion syndrome