<unk> <unk>  is any type of epithelial lung<unk>  other than<unk> -cell lung<unk> <unk> .<unk>  may be classified according to the WHO histological classification system into 3 main types; Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Other less common subtypes include adenosquamous lung carcinoma, pulmonary sarcomatoid carcinoma, carcinoid tumors of the lung, and carcinomas of the lung of salivary gland type.<unk>  arises from the epithelial cells of the lung of the bronchi to the alveoli, which are normally involved in the protection of the airways.<unk>  is an invasive and rapidly growing<unk>  which may metastasize to different organs of the body. Genes involved in the pathogenesis of<unk>  include multiple oncogenes, such as EGFR, KRAS, HER2, BRAF, ROS-1, ALK, AKT1, MEK1, MET, NRAS, PIK3CA, and RET. The primary cause of<unk>  is DNA damage.<unk>  is the leading cause of<unk> -related death among both men and women, and the most common<unk>  among the adult population in the United States.<unk> s account for about 85% of all lung<unk> s. The incidence rate of<unk>  is approximately 42.6 per 100 000 individuals in the United States. Common risk factors in the development of<unk><unk>  cell lung are smoking, family history of lung<unk> , high levels of air pollution, radiation therapy to the chest, radon gas, asbestos, occupational exposure to chemical carcinogens, and previous lung disease.<unk>  is a locally aggressive tumor, commonly occurs in patients between 65 to 74 years. Common sites of metastasis include adrenal gland, bone, brain, and liver. The 5-year relative survival of patients with<unk>  is approximately 50%. Features associated with worse prognosis are genetic markers, tumor size, associated conditions, clinical fitness for surgery, the presence of lymphatic invasion, the location of the lesion, the presence of satellite lesions, and presence of regional or distant metastases. Prognosis is generally regarded as poor with an all-stage average survival rate of 50%.  The 5-year recurrence rate of<unk>  is 24%.  Chemotherapy is indicated for<unk>  stage (IB, II, and III) as adjuvant therapy. The main therapy for<unk>  is surgical resection. Chemotherapy and chemo-radiation may be required upon histological subtype of<unk> , location, size, and lymph node involvement.
Non small cell lung cancer
Large cell carcinoma of the lung
Small cell carcinoma of the lung
Adenocarcinoma of the lung
Sarcomatoid carcinoma of the lung
Squamous cell carcinoma of the lung
Mesothelioma
Bronchoalveolar carcinoma