<unk>  is a clinical manifestation that can be caused by any pathology affecting brain function. The pathology can be intracranial or extra-cranial in origin. This brain malfunction can be due to  systemic metabolic derangements in cardiopulmonary,mitochondrial[], renal, hepatic or endocrine systems. In medical jargon it can refer to a wide variety of degenerative brain disorders with very different etiologies, prognoses and implications. For example, prion diseases, all of which cause transmissible spongiform<unk> es, are nearly always fatal and have an infectious origin, but other<unk> es are reversible and can be caused by deficiency, toxins, and several other causes.
Encephalopathy
Myopathy
Neurotoxicity
Cerebral atrophy
Encephalitis
Cerebral edema
Lipodystrophy
Myositis