The pathophysiology of<unk>  consists of an imbalance between bone resorption and bone formation. Major factors contributing to the development of<unk>  include estrogen deficit and aging. The main mechanism, by which these factors might lead to<unk>  is reactive oxygen species (ROS) induced damage to osteocytes. Decreased capability of osteocyte autophagy is another important issue; which makes them vulnerable to oxidative stresses. Genes involved in the pathogenesis of<unk>  can be categorized into four main groups namely, osteoblast regulatory genes, osteoclast regulatory genes, bone matrix elements genes, and hormone/receptor genes.
Osteoporosis pathophysiology
Osteochondroma risk factors
Osteoporosis causes
Osteoporosis differential diagnosis
Osteoarthritis causes
Osteosarcoma risk factors
Hyperparathyroidism pathophysiology
Vitamin D deficiency risk factors