<unk>  is an iodine-containing radiocontrast medium used in cholecystography. Both<unk>  and ipodate sodium are potent inhibitors of thyroid hormone release from thyroid gland, as well as of peripheral conversion of thyroxine (T4) to triiodothyronine (T3). These compounds inhibit 5'deiodinase (5'DID-1 and 5'DID-2) enzymes, which catalyse T4-T3 conversion in the thyroid cell, liver, kidney, skeletal muscle, heart, brain, pituitary. This accounts for the dramatic improvement in both subjective and objective symptoms of hyperthyroidism, particularly when they are used as an adjunctive therapy with thioamides (propylthiouracil, carbimazole). These are less toxic, as iodine is covalently bound in these compounds. They can be used in the treatment of patients with severe thyrotoxicosis (thyroid storm) and significant morbidity (e.g., myocardial infarction, or stroke) for rapid control of elevated plasma triiodothyronine concentrations.  The use of<unk>  for treatment of thyrotoxicosis has been discontinued in the United States.
In addition to inhibiting deiodinase enzymes,<unk>  is also a substrate of type 1 deiodinase.<unk>  underwent monodeiodination in the presence of type 1 deiodinase in a microsomal mouse liver preparation.
Iopanoic acid
Gamma-Linolenic acid
Choline
Meconic acid
Cyanic acid
Linoleic acid
Tyropanoic acid
Oleic acid