Pernicious anemia (also called Addison's anemia) is a type of red blood cell disorder caused by impaired vitamin B12 metabolism. Vitamin B12 is primarily absorbed by the small intestine, after being bound to intrinsic factor secreted by parietal cells of gastric mucosa. When this process is disrupted by conditions like atrophic gastritis, celiac disease, small bowel resection etc, B12 deficiency ensues.<unk>  is a mature plasma cell neoplastic proliferative disease.<unk>  is part of the broad group of diseases called hematological malignancies and is also known as plasma cell<unk> ,<unk> tosis, or Kahler disease.<unk>  can be caused by genetic mutations and chromosomal aberrations.<unk>  must be differentiated from other plasma cell disorders, such as monoclonal gammopathy of undetermined significance(MGUS), isolated plasmacytoma of the bone, and extramedullary plasmacytoma. The prognosis of<unk>  is good with treatment, while without treatment,<unk>  will result in death with a median survival of 7 months.<unk>  is the second most common blood cancer after non-Hodgkin's lymphoma and the 14th most common cancer overall in United States. There is insufficient evidence to recommend routine screening for<unk> . If left untreated, most of patients with<unk>  may progress to develop fatigue, bone pain, and pallor. Laboratory findings consistent with the diagnosis of<unk>  include abnormal complete blood count, basic metabolic panel, electrophoresis and immunohistochemistry. While patients with smoldering (asymptomatic)<unk>  are managed by observation and undergoing follow up tests every 3 to 6 months, patients with active<unk>  usually require treatment to prevent progression of disease which can lead to death.
Multiple myeloma
Monoclonal gammopathy of undetermined significance
Monoclonal gammopathy of renal significance
Familial amyloidosis
POEMS syndrome
Waldenström's macroglobulinemia
Familial renal amyloidosis
Renal amyloidosis