<unk>  is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that<unk>  inhibits both respiration and glycolysis leading to a decrease in cellular ATP.
Clinical trials of<unk>  in combination with other anticancer agents for a variety of cancers has begun.  This is due to its proven ability to inhibit energy metabolism in cancer cells, and to enhance the activity of anticancer agents.<unk>  has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. Results showed that a combination of temozolomide and<unk>  at clinically achievable, low plasma concentrations, could inhibit tumour growth, and<unk>  could reduce the dose of temozolomide required for radiosensitization of brain tumours.
A derivative of<unk> , gamendazole, is in testing as a possible male contraceptive pill.
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Bethanechol chloride