<unk>  <unk>  is defined as an at rest mean pulmonary artery pressure (mPAP) ≥ 25 mm Hg measured using right heart catheterization. <unk>  is clasified into five different ethiological groups and four functional classes according to WHO.  Multiple causes and risk factors have been identified as responsible for the presentation of<unk> , with left heart diseases and lung diseases at the top of the list.
  Pulmonary arterial hypertension (PAH) is an exclusion diagnosis which requires common causes to be ruled out and a mPAP ≥ 25 mm Hg, a pulmonary artery wedge pressure (PAWP) ≤ 15 mm Hg and a pulmonary vascular resitance (PVR) > 3 Wood Unitis (WU). The treatment of<unk>  depends upon the underlying etiology.  For PAH the treatment is based on oral endothelin receptor antagonists (ambrisentan, bosentan), oral<unk> osphodiesterase-5 inhibitors (sildenafil), and/or prostanoids (epoprostenol, treprostinil). For other causes of<unk> , the treatment would be addressed to the primary disease (eg. heart failure, COPD, interstitial lung disease)
Pulmonary hypertension
Portopulmonary hypertension
Asthma
Chronic obstructive pulmonary disease
Emphysema
Hypertensive heart disease
Pulmonary artery sclerosis
Chronic bronchitis