<unk> s are the benign<unk> s that arise from monoclonal proliferation of well-differentiated fibroblasts (which are found throughout the body). Main function of fibroblasts is in wound healing and to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines. Depending upon the underlying etiology,<unk> s can be classified as abdominal, intra-abdominal, extra-abdominal, multiple familial, associated with Gardner syndrome and associated with Turcot syndrome.<unk> s can arise in virtually any part of the body.<unk> s appear as well-differentiated, firm overgrowths of fibrous tissue with marked cellularity and aggressive local infiltration. Histologically,<unk> s consist of linearly arranged elongated fibroblasts and myofibroblasts surrounded and separated from each other by collagen. Most common frequent causes of<unk> s at molecular level include mutations in the β-catenin gene, CTNNB1, or the adenomatous polyposis coli gene, APC, all involved in Wnt/beta-catenin signaling pathway. Pediatric<unk> s have AKT1 E17K, BRAF V600E and TP53 R273H mutations also in addition to CTNNB1 mutations.<unk> s account for approximately 0.03 percent of all neoplasm and less than 3% of all the soft tissue<unk> s.They are more common in women (of fertile age) than men, and mostly occur in age of 30's to 40's. These<unk> s can be slow growing or extremely aggressive, musculoaponeurotic<unk> s without any metastatic potential. When they are aggressive they can cause life threatening problems or even death due to compression of vital organs such as the intestines, kidneys, lungs, blood vessels, and nerves. Common risk factors for<unk> s include personal or family history of FAP, Gardner syndrome, Turcot syndrome, female gender, pregnancy, estrogen therapy, history of antecedent surgical or accidental trauma or irradiation at the<unk>  site, history of breast cancer and androgens.<unk> s may be diagnosed on an imaging test done for another reason in asymptomatic patients. In symptomatic patients, it can present as a painless or painful mass/lump, insomnia, difficulty moving, nausea, vomiting, anxiety depending upon size and location of<unk> . Gold standard for diagnosis is histological examination of a biopsy specimen followed by immunohistochemistry for nuclear beta-catenin. Various imaging studies like CT, MRI, ultrasonography, color doppler, plain radiograph and angiography may aid in further diagnosis and deciding treatment strategy especially for highly recurrent<unk> s. Wait and watch therapy is applied for treatment of asymptomatic patients. For symptomatic patients various therapeutic options are available such as surgery, radiation therapy,<unk>  ablation and medical therapy with chemotherapeutic agents, anti-hormonal agents, NSAIDs and tyrosine kinase inhibitors.
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