The pathophysiology of<unk><unk><unk>  (FHH) consists of an inactivating missense mutation in the calcium-sensing receptor (CaSR) located on the short arm of the chromosome 3 (FBHH3q). The mutation of CaSR is associated with two inherited conditions FHH and neonatal hyperparathyroidism. CaSR is a plasma membrane G protein-coupled receptor which is expressed on the chief cells of the parathyroid glands and the cells lining the renal tubules. CasR has the ability to sense any changes in the circulating calcium concentration and send this information through the signaling pathway to the parathyroid gland that modifies PTH secretion.
Familial hypocalciuric hypercalcemia pathophysiology
Hyperparathyroidism pathophysiology
Parathyroid cancer risk factors
Hypoparathyroidism risk factors
Hypoparathyroidism pathophysiology
Pseudohypoparathyroidism other diagnostic studies
Hypokalemia pathophysiology
Pseudohypoparathyroidism pathophysiology