<unk>  (or<unk> 3K or MEKK) is a serine/threonine-specific protein kinase which acts upon<unk>  kinase kinase.
There are 15 genes:<unk> 3K1 (aka MEKK1)<unk> 3K2<unk> 3K3 (aka MEKK3)<unk> 3K4<unk> 3K5<unk> 3K6<unk> 3K7 (aka MEKK7)<unk> 3K8<unk> 3K9<unk> 3K10<unk> 3K11 (aka MEKK11)<unk> 3K12<unk> 3K13<unk> 3K14<unk> 3K15
MEKK1 activates<unk> K8/JNK by phosphorylation of its activator SEK1<unk> 2K4).<unk> 3K3 directly regulates the<unk> K8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.<unk> 3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).
MAP kinase kinase kinase
Rho GTPase
Janus kinase
GTPase activating protein
STAT protein
Receptor tyrosine kinase
Mitogen-activated protein kinase
G protein