Pernicious anemia (also called Addison's anemia) is a type of red blood cell disorder caused by impaired vitamin B12 metabolism. Vitamin B12 is primarily absorbed by the small intestine, after being bound to intrinsic factor secreted by parietal cells of gastric mucosa. When this process is disrupted by conditions like atrophic gastritis, celiac disease, small bowel resection etc, B12 deficiency ensues.<unk><unk>  leukemia is caused by an abnormal chromosome develops, the abnormal chromosome creates a new gene which amplifies the production rate of cells derived from hematopoeitic stem cells. First, an abnormal chromosome develops. In people with<unk><unk>  leukemia, the Philadelphia chromosome, named for the city where it was discovered, is present in the blood cells of 90 percent of people. Second, the abnormal chromosome creates a new gene, the Philadelphia chromosome creates a new gene called BCR-ABL. It contains instructions that tell the abnormal blood cell to produce too much of a protein called tyrosine kinase that promotes cancer by allowing certain blood cells to grow out of control.
Chronic myelogenous leukemia causes
Acute myeloid leukemia causes
Febrile neutropenia causes
Myelofibrosis causes
Myeloproliferative neoplasm causes
Hairy cell leukemia causes
Lymphocytopenia causes
Thrombocytopenia causes