<unk>  is a form of paraproteinemia with a proliferation of<unk><unk> s.
This<unk>  is characterized by an excessive production of immunoglobulin<unk><unk> s that are short and truncated. The amino acid sequence on the amino terminal is completely normal, but there is a deletion in the protein structure that extends from the middle of the variable region, through the first domain of the constant region, and ending just before the position of the first disulfide bond between the two<unk><unk> s. This deletion causes the<unk><unk> s to lose the ability to form disulfide bonds with the light<unk> s. The defect in the immunoglobulins arises during the faulty coupling of the variable and constant regions during somatic recombination.
Heavy chain disease
Familial renal amyloidosis
Familial amyloidosis
Monoclonal gammopathy of undetermined significance
HIV associated nephropathy
Monoclonal gammopathy of renal significance
Renal amyloidosis
Secondary amyloidosis