<unk> 's<unk> , otherwise known as osteitis deformans the<unk>  is named after the English surgeon  Sir James<unk> . It is the second most common bone<unk>  after osteoporosis worldwide. It is characterized by focal regions of highly exaggerated bone remodeling, with different abnormalities in all phases of the bone remodeling process.<unk>  is a chronic disorder that typically results in enlarged and deformed bones. It is named after Sir James<unk> , the British surgeon who first described this problem. The excessive breakdown and formation of bone tissue that occurs with<unk> 's<unk>  can cause bone to weaken, resulting in bone pain, arthritis, deformities, and fractures.<unk> 's<unk>  may be caused by a slow virus infection (i.e., paramyxoviruses such as measles and respiratory syncytial virus), present for many years before symptoms appear: indications for treatment and review of current therapies |journal=J. Bone Miner. Res. |volume=21 Suppl 2 |issue= |pages=P94–8 |date=December 2006 |pmid=17229018 |doi=10.1359/jbmr.06s218 |url=}}</ref>. There is also a hereditary factor since the<unk>  may appear in more than one family member.<unk> 's<unk>  is rarely diagnosed in people less than 40 years of age. Men are more commonly affected than women. Prevalence of<unk> 's<unk>  ranges from 1.5 to 8 percent depending on age and country of residence. Prevalence of familial<unk> 's<unk>  (where more than one family member has the<unk>  ranges from 10 to 40 percent in different parts of the world. Because early diagnosis and treatment is important, after age 40, siblings and children of someone with<unk> 's<unk>  may wish to have an alkaline phosphatase blood test every 2 or 3 years. If the alkaline phosphatase level is above normal, other tests such as a bone-specific alkaline phosphatase test, bone scan, or x-ray can be performed.<unk>  affects the normal body's bone recycling process, in which new bone tissue gradually replaces old bone tissue. Accordingly, the<unk>  made bone fragile and misshapen.<unk>  can affect any bone in human body. It appears most often in the spine, pelvis, long bones of the limbs, and skull. It can be present in just one bone or in several bones. It can affect the entire bone or just part of it.
The risk of<unk>  increases with age.<unk>  most commonly affects the pelvis, skull, spine and legs. Complications of<unk>  are broken bones, hearing loss and pinched nerves in spine. Bisphosphonates — the medications also used to strengthen bones weakened by osteoporosis — are the mainstay of treatment. For patients who have complications, surgery may be necessary.<unk><unk>  may involve a single bone but is more frequently multifocal.
Paget's disease of bone
Diffuse idiopathic skeletal hyperostosis
Albright's hereditary osteodystrophy
Giant cell tumor of bone
Primary lymphoma of the bone
Tumor induced osteomalacia
Osteopetrosis
McCune-Albright syndrome