<unk>  B is a polyene antifungal drug, often used intravenously for systemicfungal infections. It was originally extracted from Streptomyces Streptomyces nodosus, a filamentousbacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical's amphoteric properties.  Two<unk> s,<unk>  A and<unk>  B are known, but only B is used clinically, because it is significantly more active in vivo.<unk>  A is almost identical to<unk>  B (having a double C=C bond between the 27th and 28th carbons), but has little antifungal activity.
Currently, the drug is available as plain<unk>  B, as a cholesteryl sulfate<unk>  (ABCD), as a<unk><unk>  <unk> , and as a liposomal formulation (LAmB). The latter formulations have been developed to improve tolerability for the patient, but may show considerably different pharmacokinetic characteristics compared to plain<unk>  B.
Amphotericin B lipid complex
Amphotericin B cholesteryl sulfate
Amphotericin B liposomal
Micronomicin
Doxycycline monohydrate
Dapsone 
Doxycycline Hyclate
Doxycycline hyclate