<unk>  or<unk>  <unk>  is an abnormal<unk> ith a single point mutation in the β chain. At position 26 there is a change in the amino acid, from glutamic acid to lysine.<unk>  is one of the most common variant of normal hemoglobin.<unk>  can be detected on electrophoresis. This<unk> ariant is very common in Southeast Asia and it has a low frequency in black and white people.
The βE mutation affects β-gene expression creating an alternate splicing site in the mRNA at codons 25-27 of the β-globin gene. Through this mechanism, there is a mild deficiency in normal β mRNA and production of small amounts of anomalous β mRNA. The reduced synthesis of β chain may cause β thalassemia. Also, this<unk> ariant has a weak union between α and β globin, causing instability when there is a high amount of oxidant.
Hemoglobin E
Hemoglobin C
Fetal hemoglobin
PolyHeme
Paroxysmal cold hemoglobinuria
Paroxysmal nocturnal hemoglobinuria
Diamond-Blackfan anemia laboratory findings
Hereditary persistence of fetal hemoglobin