<unk><unk>  is a chronic inflammatory skin disorder with an immunologic background and occurs in patients with a personal or family history of atopy (i.e. asthma or allergic rhinitis). It is caused by either a skin barrier dysfunction or immune dysregulation of the adaptive and innate immune response leading to an enhanced IgE-mediated, systemic Th2 response. The skin barrier is invaded by exogenous substances, including allergens, irritants and microbes; and the tightly packed structure of the stratum corneum is further compromised. Systemically, a dysfunctional innate and adaptive immune response causes further damage to the epidermis.
Atopic dermatitis pathophysiology
Eczema pathophysiology
Drug allergy pathophysiology
Acrodermatitis chronica atrophicans pathophysiology
Psoriasis pathophysiology
Vitiligo pathophysiology
Mycosis fungoides pathophysiology
Scleroderma pathophysiology