The route of<unk>  (fleabite or aerosolized particles) classifies plague into: bubonic, pulmonic or septicemic.<unk><unk>  produces several virulence factors which are responsible for: evasion of the immune system, survival of the bacteria inside host cells, and<unk> s mechanisms, such as: degradation of extracellular proteins, production of endotoxins and inhibition of platelet aggregation. Y.<unk>  aggregates in different tissues, causing inflammation and necrosis, that are responsible for some of the clinical findings of plague: lymphadenopathy and abscesses (bubonic); bacteremia and sepsis (septicemic) and pneumonia and ARDS (pulmonic).
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