Direct Factor<unk><unk> s include Rivaroxaban, Betrixaban, Apixaban and Edoxaban.  These agents bind directly to a serine residue of Factor<unk>  and inhibit the ability of Factor<unk>  to bind to the active site. They work by steric hinderance. They bind reversibly. Thus there is an equilibrium where these<unk>  molecules are binding and falling off of the Factor<unk>  molecule.  Indirect<unk> s like fondaparinux and enoxaperin require antithrombin 3 (AT3) in addition.
Factor Xa inhibitor antidote
Vitamin K antagonist
Factor XIII concentrate
Thrombolysis
Thrombolytic drug
Direct Xa inhibitor
Heparinoids
Fragmin injection