<unk>   is the most common type of<unk>  cutaneous B-cell lymphoma.<unk>  (PCFCL) can be defined as neoplastic proliferation of the<unk>  germinal<unk> r cells limited to the skin.  This is a tumor of neoplastic<unk><unk>  cells, including<unk> cytes and variable numbers of<unk> blasts, with a follicular and diffuse growth pattern that generally presents on the head or trunk.Based on the growth pattern,<unk>  may be classified into  follicular, diffuse, and mixed pattern.<unk>  (PCFCL) may be associated with  borrelia burgdorferi, hepatitis C, and human herpesvirus 8. On gross pathology,solitary or grouped erythematous papules, plaques and tumor lesions, mostly non-ulcerated are characteristic findings of<unk> . On microscopic histopathological analysis,<unk> blasts (large noncleaved cells),<unk> cytes (small and large cleaved cells), and reactive T cells are characteristic findings of<unk> .There are no established causes for<unk> .<unk>  must be differentiated from other diseases such as eczema, psoriasis, and cutaneous T cell lymphoma. The incidence of<unk>  increases with age; the median age at diagnosis is 51 years. Males are more commonly affected with<unk>  than females. There are no established risk factors for<unk> . According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for<unk> .Prognosis is generally excellent, and the 5-year survival rate of patients with<unk>  is approximately 97%. The staging of<unk>  is based on the International Society for Cutaneous Lymphomas (ISCL) / EORTC proposal on TNM classification of cutaneous lymphoma other than mycosis fungoides / sezary syndrome.The most common symptoms of<unk>  include fever, fatigue, weight loss, skin rash, night sweats, skin rash, chest pain, abdominal pain, bone pain, and painless swelling in the neck, axilla, groin, thorax, and abdomen. Common physical examination findings of<unk>  include fever, rash, ulcer, firm erythematous or violaceous plaques, nodules, or tumors of varying sizes, chest tenderness, abdomen tenderness, bone tenderness, peripheral lymphadenopathy, and<unk> l lymphadenopathy.Laboratory tests for<unk>  include complete blood count (CBC), blood chemistry studies, cytogenetic analysis, flow cytometry, immunohistochemistry,  and immunophenotyping. Lymph node biopsy is diagnostic of<unk> . CT scan may be helpful in the diagnosis of<unk> .  MRI scan may be helpful in the diagnosis of<unk> . PET scan may be helpful in the diagnosis of<unk> . Other diagnostic studies for<unk>  include laparoscopy, laparotomy, bone marrow aspiration, and bone marrow biopsy. The predominant therapy for<unk>  is radiotherapy. Adjunctive chemotherapy may be required. Surgery is not the first-line treatment option for patients with<unk> . Surgery is usually reserved for patients with localized disease.
Primary cutaneous follicle centre lymphoma
Cutaneous B cell lymphoma
Cutaneous T cell lymphoma
Generalized eruptive histiocytoma
Cutaneous lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Actinic granuloma
Primary cutaneous amyloidosis