The incidence of C.<unk><unk>  is estimated to be 140 per 100,000 individuals. In USA, the majority (65%) of cases are associated with healthcare settings, and 25% of cases are associated with previous hospitalizations. Although patients of all age groups may develop C.<unk><unk> , elderly patients > 65 years may have up to eight-fold increased risk of developing C.<unk><unk>  compared with younger patients. Whites and female patients are more predisposed to develop C.<unk><unk> s. Although C.<unk>  is abundantly reported in Europe and the United States, the<unk>  is a global burden.
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