<unk>  hypocalciuric hypercalcemia must be differentiated from primary hyperparathyroidism to avoid unnecessary parathyroidectomy. Calcium creatinine clearance ratio is used to differentiate FHH from primary hyperparathyroidism, ratio < 0.01 suggestive of FHH  and > 0.01 suggestive of primary hyperparathyroidism. This genetic test of the CaSR gene is the gold standard. If negative, genetic testing for mutation of G alpha 11 and AP2S1 can diagnose FHH2 and FHH3, respectively.
Familial hypocalciuric hypercalcemia differential diagnosis
Hypoparathyroidism other diagnostic studies
Familial hypocalciuric hypercalcemia other diagnostic studies
Pseudohypoparathyroidism other diagnostic studies
Pseudohypoparathyroidism differential diagnosis
Parathyroid adenoma differential diagnosis
Parathyroid cancer differential diagnosis
Vitamin D deficiency differential diagnosis