<unk>  <unk>  is a progressive<unk> g disease of the interstitial lung diseases which leads to irreversible decline in the lung functions for unknown cause.<unk>  is one of the interstitial lung disease and particularly is a subtype of<unk>  interstitial pneumonia. Pulmonary<unk>  share the pathogenesis process of interstitial lung disease which involve the pulmonary parenchyma. Although the exact pathogenesis is not fully understood, there are many initiating factors which cause the pulmonary tissue injury. The main features of the lung injury includes inflammation,<unk> , and granulomas development. Common causes of pulmonary<unk>  include autoimmunity, rheumatoid arthritis, scleroderma, tuberculosis, SLE, sarcoidosis, and polymyositis. Other causes of pulmonary<unk>  include environmental factors as cigarette smoking and dust exposure.<unk>  must be differentiated from other causes of interstitial lung diseases which may cause<unk>  as well. Prevalence of<unk>  ranges from a low of 0.5 per 100.000 persons to a high of 27.9 per 100.000. Incidence of<unk>  ranges from a low of 3 per 100,000 persons to a high of 9 per 100,000 persons. Common risk factors of pulmonary<unk>  include cigarette smoking and genetic mutations which include hTERT, MUC5B, TERT, and RTEL1. Other risk factors include GERD and wood dust. If left untreated,<unk>  will lead to complete respiratory failure and death. Common complications of<unk>  include pulmonary hypertension, lung cancer, and cardiovascular comorbidities. The prognosis of<unk>  is usually poor with a survival rate from 2 to 5 years. Common symptoms of<unk>  include Dyspnea, cough, Clubbing, Crackles, and arthralgia. Physical examination of patients with occupational lung disease is usually remarkable for bronchial breathing, increased vocal resonance, and fine crepitations. On chest CT scan,<unk>  is characterized by honeycombing appearance of the lungs, bronchiectasis, ground glass opacities, and distortion of the lung opacities. The mainstay of the therapy is supportive care measures as mechanical ventilation. Lung transplantation is essential in treatment of patients with<unk> . Pulmonary<unk>  is the most common interstitial lung disease requiring lung transplant and it should be performed early in order to increase the survival rate.
Idiopathic pulmonary fibrosis
Idiopathic interstitial pneumonia
Occupational lung disease
CMV pneumonitis
Pulmonary amyloidosis
Chronic bronchitis
Hypersensitivity pneumonitis
Chemical pneumonitis