<unk>  was first discovered by Paul Kaznelson in 1922.<unk>  may be classified into primary (idiopathic)<unk>  and acquired<unk> <unk><unk> . It is thought that acquired<unk>  is the result of profound anemia due to severe<unk> uction in number of RBC in peripheral blood and absence of erythroid precursors, proerythroblast in the bone marrow.  Causes include autoimmune disease, thymoma, viral infections, lymphoproliferative disorders, idiopathic, drugs, ABO- incompatible hematopoietic<unk>  transplantation, Anti- erythropoietin antibodies.<unk>  must be differentiated from transient erythroblastopenia of childhood, Diamond-Blackfan anemia (DBA) and aplastic anemia. The incidence of Diamond-Blackfan anemia (DBA) is approximately 6.6 per 100,000 individuals in Europe.<unk>  due to Diamond-Blackfan anemia (DBA) affects men and women equally. Common risk factor in the development of<unk>  include strong family history. If left untreated, 14% of patients with<unk>  may have spontaneously remitting disease.<unk>  due to parvovirus infection usually resolve within 2-3 weeks. Common complications of<unk>  include infection due to side effects of some treatments. Prognosis is generally good. Diagnostic study of choice include complete blood count, peripheral smear, reticulocyte count, hepatic function test, renal function test, bone marrow aspiration and biopsy. Common symptoms of<unk>  include fatigue and lethargy. Laboratory findings consistent with the diagnosis of<unk>  include normocytic, normochromic anemia, very low or zero reticulocyte percentage and an absolute reticulocyte count <10,000/microL, normal white blood<unk>  and platelets. An x-ray may be helpful in the diagnosis of thymoma and other neoplasms. Medical therapy include<unk>  blood<unk>  transfusion in symptomatic anemia, cessation of offending drugs, Intravenous immune globulin (IVIG) in resistant<unk> , Immunosuppressive therapy in idiopathic<unk> . Surgery is usually reserved for patients with thymoma.
Pure red cell aplasia
Paroxysmal cold hemoglobinuria
Paroxysmal nocturnal hemoglobinuria
Hereditary spherocytosis
Hereditary persistence of fetal hemoglobin
Familial erythrocytosis
Congenital dyserythropoietic anemia
Congenital hemolytic anemia