Eosinophilic granulomatosis with polyangiitis is a medium and small vessel vasculitis, leading to necrosis and vasculitis. The pathogenesis of eosinophilic granulomatosis with polyangiitis is not fully understood. It may occur as a  result of a complex interaction involving genetic and environmental factors that lead to an inflammatory response involving eosinophils, lymphocytes and giant cells. Autoimmunity has an evident role in the presence of ANCA, hypergammaglobulinemia, elevated levels of immunoglobulin E, and rheumatic factor in the pathogenesis. HLA-DRB4 is correlated with increased risk of development of vascular manifestations of the churg-strauss syndrome. On microscopic  pathology, eosinophlic infiltration, necrotizing granulomas vasculitis and necrosis of small and medium-sized arteries can be seen.
Churg-Strauss syndrome pathophysiology
Adams-Stokes syndrome pathophysiology
Churg-Strauss syndrome laboratory findings
Lymphangitis pathophysiology
Buerger's disease pathophysiology
Behçet's disease pathophysiology
Takayasu's arteritis pathophysiology
Goodpasture syndrome pathophysiology