Coagulase-negative staphylococci
Staphylococcus aureus, including methicillin-resistant strains
Enterococcus species, including vancomycin-resistant strains
Viridans group streptococci
Streptococcus pneumoniae
Streptococcus pyogenes
Escherichia coli
Klebsiella species
Enterobacter species
Pseudomonas aeruginosa
Citrobacter species
Acinetobacter species
Stenotrophomonas maltophilia
Hypotension: systolic blood pressure less than 90 mmHg or need for pressor support to maintain blood pressure
Respiratory failure: arterial oxygen pressure less than 60 mmHg while breathing room air or need for mechanical ventilation Intensive care unit admission
Disseminated intravascular coagulation
Confusion or altered mental state
Congestive cardiac failure seen on chest x-ray and requiring treatment
Bleeding severe enough to require transfusion
Arrhythmia or ECG changes requiring treatment
Renal failure requiring investigation and/or treatment with IV fluids, dialysis, or any other intervention
Other complications judged serious and clinically significant by the investigator†
† All reviewed by one investigator. Viral or fungal, microbiologically documented primary infection during the<unk>  episode, without any described complication and resolving under therapy, was considered a part of the infectious process and was not considered a serious complication.
Characteristic
Weight
The maximum value of the score is 26.  a Burden of<unk>  refers to the general clinical status of the patient as influenced by the<unk>  episode. It should be evaluated on the following scale: no or mild symptoms (score of 5); moderate symptoms (score of 3); and severe symptoms or moribund (score of 0). Scores of 3 and 5 are not cumulative.  b Chronic obstructive pulmonary disease means active chronic bronchitis, emphysema, decrease in forced expiratory volumes, need for oxygen therapy and/or steroids and/or bronchodilators requiring treatment at the presentation of the<unk>  episode.  c Previous fungal infection means demonstrated fungal infection or empirically treated suspected fungal infection.
Bacterial - None
Fungal - None
Viral - None except positive HSV serology
Bacterial - Consider fluoroquinolone prophylaxis
Fungal - Consider antifungals during neutropenia and for anticipated mucositis
Viral - During neutropenia and at least 30 days after HSCT
Bacterial - Consider fluoroquinolone prophylaxis
Fungal - Consider antifungals during neutropenia and for anticipated mucositis
Viral - During neutropenia and at least 30 days after HSCT; also consider pre-emptive therapy against CMV or HBV
Disease/Therapy
Antifungal prophylaxis<unk>  is a condition characterized by a decrease in neutrophils (neutropenia) associated with the development of fever, the latter indicating the presence of an infection.  The majority of patients have no identifiable site of infection and no positive culture results. Nonetheless, urgent treatment with empirical antibiotics is recommended in light of the possibility of rapid progression.
Febrile neutropenia
Cyclic neutropenia
Agranulocytosis
Granulocytosis
Leukopenia
Pancytopenia
Lymphocytopenia
Lymphocytosis