<unk>  (USAN) or<unk> in (INN) is a bactericidal antibiotic drug of the rifamycin group.<unk>  inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase.
It is a semisynthetic compound derived from Amycolatopsis rifamycinica  (formerly known as Amycolatopsis mediterranei and Streptomyces mediterranei). <unk> in may be abbreviated R, RMP, RA, RF, or RIF (US).
In 1957, a soil sample from a pine forest on the French Riviera was brought for analysis to the Lepetit Pharmaceuticals research lab in Milan, Italy. There, a research group headed by Prof. Piero Sensi (1920-) and Dr. Maria Teresa Timbal (1925 - 1969) discovered a new bacterium. This new species appeared immediately of great scientific interest since it was producing a new class of molecules with antibiotic activity. Because Sensi, Timbal and the researchers were particularly fond of the French crime story Rififi (about a jewel heist and rival gangs), they decided to call these compounds "rifamycins". After two years of attempts to obtain more stable semisynthetic products, a new molecule with high efficacy and good tolerability was produced in 1959 and was named "rifampicin".<unk> in is also known as rifaldazine, R/AMP, rofact (in Canada), and<unk>  in the United States. There are various types of rifamycins from which this is derived, but the<unk> in form, with a 4-methyl-1-piperazinaminyl group, is by far the most clinically effective.<unk> , also known as isonicotinylhydrazine (INH), is an organic compound that is the first-line medication in prevention and treatment of tuberculosis. The compound was first synthesized in the early 20th century, but its activity against tuberculosis was first reported in the early 1950s, and three pharmaceutical companies attempted unsuccessfully to simultaneously patent the drug (the most prominent one being Roche, which launched its version, Rimifon, in 1952). The drug was first tested at Many Farms, a Navajo community, due to the Navajo reservation's dire tuberculosis problem and the fact that the population was naïve with respect to streptomycin, the main tuberculosis treatment at the time. With the introduction of<unk> , a cure for tuberculosis was first considered reasonable.
Pyrazinamide is a drug used to treat tuberculosis.  The drug is largely bacteriostatic, but can be bacteriocidal on actively replicating tuberculosis bacteria.
Rifampin isoniazid pyrazinamide
Amphotericin B liposomal
Ethambutol
Pyrazinamide
Safinamide
Isoniazid 
Monoxerutin
Quinupristin-Dalfopristin