<unk>  (also known as  "PLB") is an uncommon malignancy that accounts for less than 5% of all<unk>  bone tumors. The majority of cases are of the non-Hodgkin type; Hodgkin disease accounting for only 6% of the cases.<unk>  was first discovered by Parker and Jackson in 1939. The pathogenesis of<unk>  is characterized by excessive osteoclast activation.<unk>  is commonly located in bone marrow, axial skeleton, or femur (most common).<unk>  may be classified according to location into solitary, multifocal, distant, and visceral subtypes. Mutations in BCL2 and BCL6 genes have been associated with the development of<unk> .<unk>  is rare; the prevalence of<unk>  is approximately 0.01 per 100,000 individuals worldwide.<unk>  is more commonly observed among middle aged adults and elderly patients. MRI is the imaging modality of choice for<unk> . The mainstay of therapy for<unk>  is chemotherapy.
Primary lymphoma of the bone
Tumor induced osteomalacia
Bone metastasis
Giant cell tumor of bone
Aneurysmal bone cyst
Metastatic calcification
Osteoid osteoma
Osteoma