<unk>  (also called the kinky hair disease or<unk>  kinky hair syndrome) is a disorder that affects copper levels in the body. It is characterized by sparse and coarse hair, growth failure, and deterioration of the nervous system. Onset of<unk>  syndrome typically begins during infancy. Signs and symptoms of this disorder include weak muscle tone (hypotonia), sagging facial features, seizures, mental retardation, and developmental delay. The patients have brittle hair and metaphyseal widening. In rare cases, symptoms begin later in childhood and are less severe. It is a X-linked recessive disorder, and is therefore considerably more common in males: females require two defective alleles to develop the disease.
It was originally described by<unk>  et al in 1962.
Occipital horn syndrome (sometimes called X-linked cutis laxa), is a mild form of<unk>  syndrome that begins in early to middle childhood. It is characterized by calcium deposits in a bone at the base of the skull (occipital bone), coarse hair, and loose skin and joints.
Menkes disease
Canavan disease
Sandhoff disease
Pick's disease
Farber disease
Kennedy disease
Carnevale-Canun-Mendoza syndrome
Aceruloplasminemia