The<unk> s are a new class of cytotoxic molecules, including<unk>  A,<unk>  B, and<unk>  D, identified as potential chemotherapy drugs.  Early studies in cancer cell lines and in human cancer patients indicate superior efficacy to the taxanes.  Their mechanism of action is similar to that of the taxanes, but their chemical structure is simpler and they are more soluble in water.  Due to improved water solubility, cremophors (solubilizing agents used in paclitaxel which can affect cardiac function and cause severe hypersensitivity) are no longer needed in the formulation of this anticancer drug. Other undesired effects such as endotoxin-like properties where macrophages are actived to synthesize inflammatory cytokines and nitric oxide (paclitaxel) are not observed by<unk>  B.<unk> s were originally identified as metabolites produced by the myxobacterium Sorangium cellulosum.
Epothilone
Terconazole
Econazole
Ethisterone
Fludrocortisone acetate
Metenolone enanthate
Sulconazole
Metenolone