<unk>  <unk>  is a class of non-Hodgkin's lymphoma, which is a type of cancer of the immune system.<unk>  <unk>  is infiltration of malignant T<unk> s and activated T<unk> s  in the skin.<unk>  arises from T-cell lymphocytes, which are normally involved in the<unk>  mediated immune response. The malignant T<unk> s in the body are pushed to the surface of the skin in a biological process used to rid the body of offending material, causing various lesions to appear on the skin. These lesions change shape as the disease progresses, typically beginning as what appears to be a rash and eventually forming plaques and tumors before metastatizing to other parts of the body. Early-stage of<unk>  <unk>  limited to the skin, tumor<unk> s in later stage disease can populate blood or lymph nodes. There are 3 classification methods used to classify<unk>  into several subtypes. Mycosis Fungoides was first described in 1806 by French dermatologist Jean-Louis-Marc Alibert. Sezary's disease was first described by Albert Sézary. On microscopic histopathological analysis,  atypical lymphoid<unk> s,  polymorphous inflammatory infiltrate in the dermis, and lymphocytes with cerebroid nuclei are characteristic findings of mycosis fungoides.<unk>  is caused by a mutation in the T<unk> s.<unk>  must be differentiated from other diseases such as  eczema and psoriasis. Mycosis fungoides commonly affects  45 and 55  years. Sézary syndrome commonly affects 60 years. In the United States, males are more commonly affected with<unk>  than females. In the United States,<unk>  usually affects individuals of the African American race.There are no established risk factors for<unk> . If left untreated,<unk>  may progress to develop patches , plaque, and tumors. Depending on the extent of the lymphoma at the time of diagnosis, the prognosis may vary. According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for<unk> .The staging of<unk>  is based on skin, lymph node, visceral and blood involvement.The most common symptoms of<unk>  include fever, weight loss, skin rash, night sweats, itching, chest pain, abdominal pain, and bone pain. Common physical examination findings of<unk>  include fever, rash, pruritus, ulcer, chest tenderness, abdominal tenderness, bone tenderness, peripheral lymphadenopathy, and central lymphadenopathy.Laboratory tests for<unk>  include complete blood count (CBC), blood chemistry studies, flow cytometry, immunohistochemistry,  and immunophenotyping. The definitive diagnosis of<unk>   is confirmed by either a or multiple skin biopsy or a lymph node biopsy. CT scan may be helpful in the diagnosis of<unk> . MRI may be helpful in the diagnosis of<unk> . PET scan may be helpful in the diagnosis of<unk> .Other diagnostic studies for<unk>  include bone marrow aspiration and bone marrow biopsy.The predominant therapy for<unk>  is PUVA. Adjunctive chemotherapy, radiotherapy, biological therapy, retinoid therapy, and photophoresis may be required.
Cutaneous T cell lymphoma
Cutaneous B cell lymphoma
Primary cutaneous follicle centre lymphoma
Cutaneous lymphoma
Generalized eruptive histiocytoma
Primary cutaneous amyloidosis
Subcutaneous panniculitis-like T-cell lymphoma
Actinic granuloma