<unk>  <unk>  are a group of<unk>  disorders against multiple (poly) endocrine organs, although non endocrine organs may be affected.
On the basis of organ involvement,<unk>  <unk>  can be classified into<unk>  type 1,<unk>  type 2 and<unk>  type 3. In<unk>  there is loss of self tolerance or defective T cell regulation and the immune system attacks various endocrine and nonendocrine organs throughout the body.<unk>  is seen in genetically susceptible individuals, when exposed to certain environmental triggers (such as infection) leads to<unk> ty. Common causes of<unk>  include mutation in AIRE gene, FOXP3 gene and certain HLA alleles such as DR3/DQ2, DR4/DQ8 and DRB1*0404. There are no established risk factors for<unk> . However, patients with single<unk>  disorder are at an increased risk of having another<unk>  disorder. The most common symptoms of<unk> -1 include mucocutaneous candidiasis, hypoparathyroidism and Addison's disease. The most common symptoms of<unk> -2 include Addison's disease with<unk>  thyroiditis or diabetes mellitus type 1. The most common symptoms of<unk>  3 include<unk>  thyroiditis, diabetes mellitus type 1, pernicious anemia and/or with involvement of a nonendocrine organ. The diagnosis of<unk>  <unk>  is made on the basis of presence of organ-specific antibodies (serological measurement) followed by functional testing. Medical therapy for<unk>  <unk>  depends upon the subtype and the organ system involved. In<unk>  the focus is to treat the presenting disorder.
Autoimmune polyendocrine syndrome
Multiple endocrine neoplasia
Secondary adrenal insufficiency
ACTH-secreting tumor
Neuroendocrine tumors
Sheehan's syndrome
Graves' disease
Addison-gull syndrome