<unk> or Hand-Foot syndrome is a skin-related reaction involving the palms an soles. It commonly occurs due to a reaction to different kinds of chemotherapeutic agent used to treat cancer. The first s. PPE may be classified into grade1, grade 2, grade 3, or grade 4 depending on toxicity rating. The pathophysiologic mechanism of<unk> is under active investigation and different mechanisms have been postulated.  Histologic biposy is consistent with toxic reaction. After extensive studies, it has been determined that Pegylated Liposomal doxorubicin deposits into the eccrine glands which is concentrated in the palms and soles which then causes a drug reaction and development of PPE.. Several Different types of Chemotherapeutic agents have been associated with the development of<unk>  PPE must be differentiated from Acute Graft Versus Host Response, Tinea manuum and Hand-Foot reaction due to tyrosine kinase inhibitor.
Palmar Plantar Erythrodysesthesia​
Palmar plantar erythrodysesthesia
Paraesthesia
Amychophobia
Binasal hemianopsia
Tactile fremitus
Hemiparesis and Hemiplegia
Hyporeflexia