<unk>  (ZP-123) is a stable gap junction conduction-enhancing antiarrhythmic peptide analog that has been shown to increase gap junction intercellular conductance in cardiac myocytes. Gap junctions are protein channels that are responsible for conducting electrical impulses between cells in the heart to maintain normal rhythm. It is currently under clinical investigation for the treatment of cardiac arrhythmias – specifically atrial fibrillation. Gap junction modulation is a promising and novel mechanism of action for the treatment of cardiovascular disorders.
Rotigaptide
Pramlintide
Linaclotide
Insulin degludec
Trenonacog alfa
Insulin aspart
Insulin glulisine
Somatorelin