Bovine spongiform<unk>  is primarily diagnosed based on the clinical presentation. However, postmortem examination should be performed for the definitive diagnosis. The postmortem investigation might be done with either western blot, ELISA, rapid test for BSE (ID-Lelystad), or histopathology. The confirmation of the diagnosis is possible either with the detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Lelystad), or vacuolation of neurons and neuropil in the histopathologic examination of medulla oblongata specimen.
Bovine spongiform encephalopathy diagnostic study of choice
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Bovine spongiform encephalopathy physical examination
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St. Louis encephalitis differential diagnosis
Japanese encephalitis differential diagnosis
Encephalopathy other diagnostic studies
Enterovirus 68 diagnostic study of choice