The main mechanism is a valine to phenylalanine substitution, particularly the JAK2V617F mutation which leads to increased red blood cells. Other mechanisms include platelets, endothelial compartment, leukocytes, and plasma factors.
Polycythemia pathophysiology
Nephrotic syndrome risk factors
Myelofibrosis risk factors
Cryoglobulinemia risk factors
Thrombocytopenia pathophysiology
Essential thrombocytosis risk factors
Macrocytic anemia pathophysiology
Eosinophilia pathophysiology