<unk>  is an acronym in pharmacokinetics and pharmacology for absorption, distribution, metabolism, and excretion, and describes the disposition of a pharmaceutical compound within an organism. The four criteria all influence the drug levels and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug:
Glomerular filtration of unbound drug.
Active secretion of (free & protein-bound) drug by transporters e.g. anions such as urate, penicillin, glucuronide, sulphate conjugates) or cations such as choline, histamine.
Filtrate 100-fold concentrated in tubules for a favourable concentration gradient so that it may be reabsorbed by passive diffusion and passed out through the urine.
Sometimes, the potential or real toxicity of the compound is taken into account <unk> -Tox or<unk> T). When the Liberation of the substance (from protective coating, or other excipients) is considered, we speak of LADME.
Computational chemists try to predict the<unk> -Tox qualities of compounds through methods like QSPR or QSAR.
The route of administration critically influences<unk> .
ADME
HM 
Acyl
Benzyl
Heroic
Tic
NNK
MMDA 