<unk> es are diseases caused by disturbed function of ion channel subunits or the proteins that regulate them.  These diseases may be either congenital (often resulting from a mutation or mutations in the encoding genes) or acquired (often resulting from autoimmune attack on an ion channel).
There are a large number of distinct dysfunctions known to be caused by ion channel mutations.  The genes for the construction of ion channels are highly conserved amongst mammals and one condition, hyperkalemic periodic paralysis, was first identified in the descendants of Impressive, a pedigree race horse.
The<unk> es of human skeletal muscle include hyper-, hypo- and normokalemic (high, low and normal potassium blood concentrations) periodic paralysis, myotonia congenita and paramyotonia congenita.
Channelopathy
Conduction system disease
Cardiac fibrosis
Cardiac arrhythmia
Myopathy
Myocardial injury
Cardiomyopathy
Myocardial inflammation