<unk>  is a rare, mulitisystem disorder.<unk>  stands for the disorder's features, which may include polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy (weakness, numbness and tingling); enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); an increase in the number of plasma cells in blood (mature B type cells); and darkening of the skin (hyperpigmentation). Various other symptoms may also occur and may vary among affected people. The underlying cause of the disorder is not well understood.<unk>  is a chronic disorder, with a median survival time of 8-14 years. There is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation.
POEMS syndrome
Monoclonal gammopathy of undetermined significance
Familial amyloidosis
Secondary amyloidosis
Multiple myeloma
Hamman-Rich syndrome
Waldenström's macroglobulinemia
Monoclonal gammopathy of undetermined significance surgery