<unk>  is a drug which is used in scientific research. It is a potent, orally active analgesic drug, which produces little respiratory depression.<unk>  itself is a potent and selective agonist for δ-opioid receptors, with a Ki of 0.24nM at δ and 72nM at μ. However once inside the body,<unk>  is dealkylated to its monodesethyl metabolite<unk> -413,216 which is a potent agonist at the μ-opioid receptor and has less affinity for δ (Ki 0.26nM at μ, 46.7nM at δ). The effect of<unk>  when administered in vivo thus produces potent agonist effects at both μ and δ receptors through the combined actions of the parent drug and its active metabolite, with the δ-agonist effects counteracting the respiratory depression from the μ-opioid effects, and the only prominent side effect being sedation.
RWJ-394,674
NNC 63-0532
BW373U86
SI prefix
ATC code S01
Parts-per notation
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