<unk>  definition (need 1 from each category):
Presence of at least 1 of the following: DVT, arterial thrombosis, or pregnancy morbidity (eg fetal loss, preterm)
Presence of at least 1 of the following<unk>  antibodies (aPL): lupus anticoagulant (LA), anticardiolipin (aCL), β2-glycoprotein-1 (β2-GP-1)
Presence of at least 1 of the following: DVT, arterial thrombosis, or pregnancy morbidity (eg fetal loss, preterm)
Presence of at least 1 of the following<unk>  antibodies (aPL): lupus anticoagulant (LA), anticardiolipin (aCL), β2-glycoprotein-1 (β2-GP-1)<unk>  can occur as a primary condition or in setting of underlying disease (eg SLE)
Lifelong anticoagulation with warfarin, with the following target INRs
2.0-3.0 for venous
3.0 for arterial
3.0-4.0 recurrent thrombosis
ASA plus warfarin for severe/refractory cases
2.0-3.0 for venous
3.0 for arterial
3.0-4.0 recurrent thrombosis
ASA plus warfarin for severe/refractory cases
Currently accepted theory: Susceptible patients (eg SLE) develop aPL after infection. After development of aPL, “second hit” stress required to develop full-blown<unk> . aPL affects coagulation by interacting with protein C, annexin V, platelets, proteases, tissue factor, and impairing fibrinolysis
“Second hit” stressors: smoking, prolonged immobilization, pregnancy, exogenous estrogen, malignancy, nephrotic syndrome, hypertension, hyperlipidemia
“Second hit” stressors: smoking, prolonged immobilization, pregnancy, exogenous estrogen, malignancy, nephrotic syndrome, hypertension, hyperlipidemia
Antiphospholipid syndrome
Disseminated Intravascular Coagulation 
Factor V Leiden
Thrombotic Thrombocytopenic Purpura 
Von Willebrand disease
Hemolytic Uremic Syndrome 
Heparin-Induced Thrombocytopenia 
HELLP syndrome