Most people asymptomatic
Severity increases with age
2-14 day incubation
Illness for 3-6 days
Malaise, anorexia, nausea/vomiting, eye pain, headache, myalgia, rash
20% of infected patients get<unk> <unk>  fever
<1% get severe neuro problem- encephalitis, meningitis, acute flaccid paralysis
Can also get movement disorder- tremor, myoclonus, Parkinsonism, bradykinesia
Can also have cranial nerve involvement, optic neuritis, seizure
Myocarditis, pancreatitis, fulminant hepatitis
Acute flaccid paralysis
Weakness can affect upper or lower limbs and can happen without meningitis
Can become hypo/areflexic, acute bowel and bladder dysfunction, absence of pain, or sensory changes
CSF has increased protein and pleocytosis
Similar to polio with destruction of spinal anterior horn cells as opposed to GBS
Weakness can affect upper or lower limbs and can happen without meningitis
Can become hypo/areflexic, acute bowel and bladder dysfunction, absence of pain, or sensory changes
CSF has increased protein and pleocytosis
Similar to polio with destruction of spinal anterior horn cells as opposed to GBS
West Nile virus
Meningitis
Zika virus
SAH
Heartland virus
Lyme disease
Hantavirus
Brain abscess