Local<unk>  is primarily clinically diagnosed based on lesion characteristics and appearance
Confirmatory tests: KOH preparation of lesion scrapings, vaginal wet mount, culture, or endoscopic biopsy reveal budding yeast with pseudohyphae
Candidiasis
CMV esophagitis
Otomycosis
HSV esophagitis
Sporotrichosis
Diphtheria 
Histoplasmosis
Pill esophagitis 