Tachycardia is typically most predominant, hypotension is a late and ominous sign
Neonatal<unk> Early onset
First few days of life
Fulminant, associated with maternal or perinatal risk factors
Septic shock and neutropenia are more common
Late onset
Occurs after 1wk of age
Gradual
Meningitis more likely
Consider if feeding disturbance, rash, lethargy, irritability, seizure, apnea, tachypnea, grunting, vomiting, poor PO, gastric distention, diarrhea
Early onset
First few days of life
Fulminant, associated with maternal or perinatal risk factors
Septic shock and neutropenia are more common
Late onset
Occurs after 1wk of age
Gradual
Meningitis more likely
Consider if feeding disturbance, rash, lethargy, irritability, seizure, apnea, tachypnea, grunting, vomiting, poor PO, gastric distention, diarrhea
First few days of life
Fulminant, associated with maternal or perinatal risk factors
Septic shock and neutropenia are more common
Occurs after 1wk of age
Gradual
Meningitis more likely
Sepsis 
THE MISFITS [1]
Tumor lysis syndrome
Trauma
Hemorrhagic shock
Heart
Toxic shock syndrome
Congenital heart disease