Pregnancy risk: B
Lactation: excreted in breastmilk, risk likely minimal
Renal Dosing
Adult - all indications
CrCl 20-40: 2.25 g q6h (3.375 g q6h if HCAP)
CrCl < 20: 2.25 g q8h (2.25 g q6h if HCAP)
HD: 2.25 g q12h (2.25 g q8h if HCAP), both PLUS 0.75 g supplement after each dialysis
PD: 2.25 g q12h (2.25 g q8h if HCAP)
Pediatric
Hepatic Dosing - no change
Adult - all indications
CrCl 20-40: 2.25 g q6h (3.375 g q6h if HCAP)
CrCl < 20: 2.25 g q8h (2.25 g q6h if HCAP)
HD: 2.25 g q12h (2.25 g q8h if HCAP), both PLUS 0.75 g supplement after each dialysis
PD: 2.25 g q12h (2.25 g q8h if HCAP)
Pediatric
CrCl 20-40: 2.25 g q6h (3.375 g q6h if HCAP)
CrCl < 20: 2.25 g q8h (2.25 g q6h if HCAP)
HD: 2.25 g q12h (2.25 g q8h if HCAP), both PLUS 0.75 g supplement after each dialysis
PD: 2.25 g q12h (2.25 g q8h if HCAP)
Piperacillin/Tazobactam
Meropenem
Imipenem/Cilastatin
Ampicillin/Sulbactam
Vancomycin
Ertapenem
Cefepime
Aztreonam