<unk>  is paroxysmal, nondemarcated swelling of dermal or submucosal layers of skin or mucosa
Swelling is asymmetric, nonpitting, and nonpruritic, however can be associated with allergic features depending on cause
Isolated uvular<unk> , or Quincke's disease, is a relatively rare presentation of<unk>  of the upper airway
Swelling is asymmetric, nonpitting, and nonpruritic, however can be associated with allergic features depending on cause
Isolated uvular<unk> , or Quincke's disease, is a relatively rare presentation of<unk>  of the upper airway
Histamine-mediated
Allergic<unk> : IgE–mediated type I hypersensitivity reaction
Bradykinin-mediated
Hereditary<unk> : Congenital or acquired loss of C1 esterase inhibitor
Due to C1 esterase inhibitor deficiency
Leads to unregulated activity of vasoactive mediators (bradykinin) associated with complement pathway
Autosomal dominant
ACE-I-induced<unk> : ACE-I adverse reaction from excessive bradykinin
Idiopathic
Allergic<unk> : IgE–mediated type I hypersensitivity reaction
Hereditary<unk> : Congenital or acquired loss of C1 esterase inhibitor
Due to C1 esterase inhibitor deficiency
Leads to unregulated activity of vasoactive mediators (bradykinin) associated with complement pathway
Autosomal dominant
ACE-I-induced<unk> : ACE-I adverse reaction from excessive bradykinin
Due to C1 esterase inhibitor deficiency
Leads to unregulated activity of vasoactive mediators (bradykinin) associated with complement pathway
Autosomal dominant
Angioedema
Allergic reaction/urticaria
Lymphedema
Anaphylaxis
Lymphangitis
Cyanosis
Anxiety attack
Asthma exacerbation