Tranexamic acid (TXA) lowers risk of death if administed in less then 3 hours after injury in trauma patients with significant hemorrhage (CRASH-2 trail)
Thromboelastography (TEG) has been extensively studied in cardiac surgery and quantifies the coagulation cascade
Factor VII, studied in the CONTROL trial, showed no mortality benefit and was terminated early
Other studies of Factor VII have raised concerns for MI and adverse thrombotic events
Consider giving calcium and magnesium IV supplementation if approaching > 4 units of pRBCs
Other studies of Factor VII have raised concerns for MI and adverse thrombotic events
Massive transfusion
Exchange transfusion
Transfusion-associated circulatory overload
Platelet transfusion
Blood products
Extracorporeal membrane oxygenation
Fresh frozen plasma
Cryoprecipitate transfusion