Pregnancy: B
Lactation: Use caution
Renal Dosing
Considerations for hemodialysis/peritoneal dialysis and CRRT patients NOT included below
Adult
Adult
Loading dose: IV: 3.1 g one dose, followed by maintenance dose based on creatinine clearance:
CrCl 30-60 mL/minute: 2 g of<unk>  component every 4 hours
CrCl 10-30 mL/minute: 2 g of<unk>  component every 8 hours
CrCl <10 mL/minute: 2 g of<unk>  component every 12 hours
CrCl <10 mL/minute with concomitant hepatic dysfunction: 2 g of<unk>  component every 24 hours
Pediatric
Pediatric
No dosing adjustments in manufacturer's label, clinical recommendations include:
GFR >30 mL/minute/1.73 m2: No adjustment required.
GFR 10-29 mL/minute/1.73 m2: 50 to 75 mg<unk> /kg every 8 hours
GFR <10 mL/minute/1.73 m2 (without concomitant hepatic failure): 50 to 75 mg<unk> /kg every 12 hours
GFR <10 mL/minute/1.73 m2 (with concomitant hepatic failure): 50 to 75 mg<unk> /kg every 24 hours
Hepatic Dosing
Adult
Adult
With concomitant renal dysfunction (Clcr <10 mL/minute): 2 g of<unk>  component every 24 hours.
Pediatric
Pediatric
No specific pediatric recommendations, adjust if concomitant renal dysfunction
Ticarcillin/Clavulanate
Imipenem/Cilastatin
Amoxicillin/Clavulanate
Ceftolozane/tazobactam
Bacitracin
Ampicillin/Sulbactam
Oxacillin
Meropenem