De novo
In general usage, de novo (literally 'of new') is a Latin expression used in English to mean 'from the beginning', 'anew'.
De novo may also refer to:

Science and computers
De novo mutation, a new germline mutation not inherited from either parent
De novo protein design, the creation of a protein sequence that is not based on existing, natural sequences
De novo protein structure prediction, the prediction of a protein's 3D structure, based only on its sequence
De novo synthesis of complex molecules from simple molecules in chemistry
De novo transcriptome assembly, the method of creating a transcriptome without a reference genome, using de novo sequence assembly
De novo gene birth, the emergence of genes from non-coding sequence
De novo assembly in genomics
De Novo classification, a pathway to classify new medical devices provided by the US Federal Food, Drug, and Cosmetic Act
Denovo, a supercomputer project that simulates nuclear reactions; see Titan (supercomputer) § Projects

Other
De novo review, an appellate standard of review for legal issues
Trial de novo, or a new trial in the legal system
De novo bank, a state bank that has been in operation for five years or less
De Novo, a public housing estate in Kai Tak, Hong Kong
Denovo (band), a 1980s Italian new wave group