2B
2B  or 2-B may refer to:

2B (band), a Portuguese band
2B (film), a 2009 science fiction film
2B lead, a grading of pencil hardness
2B (Nier: Automata), the video game's main protagonist
2b Theatre Company, a theatre company in Halifax, Nova Scotia
2b2t, а Minecraft server with no rules
Aerocondor, IATA airline code 2B
Alpha-2B adrenergic receptor, a type of protein structure
Haute-Corse, French department 2B (northern Corsica)
Second baseman, a fielding position in baseball
Double (baseball), a type of base hit
Stalag II-B, a prisoner of war camp in Germany
Transcription factor II B, a type of protein structure
Type IIb diamond, a classification of natural diamonds
Type IIB string theory, a physical theory about the basic substance of the universe
II-b or IIb, a subtype of Type II supernova

See also
B2 (disambiguation)
IIB (disambiguation)