(Shanghai, China. http:// www. pnp- med. com/). Authors’ Contributions YJY was involved in conceptualization, resources, data curation, formal analysis, funding acquisition, inves- tigation, methodology, writing–original draft, project administration, writing–review and editing. NS contributed to resources, data cura- tion, formal analysis, investigation, methodology, writing–review and editing. LYL and YSZ were involved in data curation, formal analysis, investigation, methodology, writing–original draft, writing- review and editing. LML, CCM, TTH, XPS XS and ZC contributed to resources, data curation, writing–review and editing. All authors read and approved the final manuscript. Funding This work was supported by the Wenzhou Major Science and Technology Special Project from Wenzhou Science and Technology Bureau (2018ZY004); the Public Benefit Technology Research Project of Zhejiang Science and Technology Department (LGF20H160019, LGF21H160035, LGF22H160044); and the Research Foundation of Academician Helin Workstation (Item No. 19331103); and the Project of Wenzhou science and Technology Bureau (Y20180634); the Key Research and Development Program of Zhejiang Province (Grant No.: 2021C03120). Data availability statement The data generated in this study are avail- able within the article. Declarations Conflict of interest The authors declare no potential conflicts of inter - est. Ethics Approval and Consent to Participate The study was approved by the Medical Ethics Committee of the Second Affiliated Hospital of Wenzhou Medical University (MEC numbers: LCKY2018-67). The protocols were strictly performed according to the Helsinki Dec- laration, and the study adhered to the privacy rights of humans. All enrolled patients signed a written informed consent form. Consent for Publication All authors have consented to the publication of the manuscript. Open Access This article is licensed under a Creative Commons Attri- bution 4.0 International License, which permits use, sharing, adapta- tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/.