2. 1 D ose Selecti o n/ M o dific ati o n 5. 2. 1. 1 D ose Selecti o n T he r ati o nale f or selecti o n of d oses t o be us e d i n t his trial is pr o vi de d i n Secti o n 4. 0 – Bac k gr o u n d a n d Rati o nal e. Details o n pre parati o n a n d a d mi nistrati o n of i pili m u ma b a n d ni v ol u ma b are pr o vi de d i n t he I n v esti gat or Br o c h ure. D etails o n pr e par ati o n a n d a d mi nistrati o n of A d. p 5 3 -D C ar e pr o vi de d i n A p pe n di x 1 1. 4. 5. 2.