NCT03730948 DC Vaccine for Colorectal Cancer Page 2 of 34 Version 7.11-11-2021 CONFIDENTIAL This protocol is the property of the University of Pennsylvania. Do not disclose or use except as authorized in writing by the study spons or. Schema Screen ing/Enrollment Pre-treatment Visit (≤ 14 days) Apheresis #1 (~D ay -7) CTX 300 mg /mg 2 IV [Day -3 (+/ - 1 day)] Day 1 : DC Vaccine #1 (Priming Vaccine) DC Vaccine #2 and DC Vaccine #3 (Booster Vaccines) (~q6 weeks) Apheresis #2 (7 -14 days after last DC Vaccine) End of Study Treatment Visit (30 days +/- 7 days post- last DC vaccine) Post-DC Vaccine Surveillance (every 3 months +/- 2 weeks) End of Study Visit (12 months +/ - 2 weeks post DC Vaccine #1) DC Vaccine for Colorectal Cancer Page 3 of 34 Version 7.11-11-2021 CONFIDENTIAL This protocol is the property of the University of Pennsylvania. Do not disclose or use except as authorized in writing by the study spons or.