0 Date 1 9 A pr 2 0 2 3 C O N FI D E N TI A L A N D P R O P RI E T A R Y 4 7 of 6 5 I n di vi d ual d ur val u ma b a n d tre meli m u ma b c o nce ntrati o ns i n ser u m ( C ma x a n d Cmi n ), ti me t o Cma xa n d A U C will be use d t o descri be t he P K of d ur val u ma b a n d tre meli m u ma b. P h ar m ac o ki netic n o n -c o m p art me nt al a n al ysis T he act ual sa m pli n g t i mes will be use d i n t he P K calc ulat i o ns. P K para meters will be deter mi ne d usi n g sta n dar d n o n -c o m part me ntal met h o ds. 3.