............................... 99 APPENDIX 4: GUIDANCE ON CONTRACEPTION ................................ ........ 100 LIST OF TABLES Table 1: Visits and assessments schedule (Arm A: OSE2101) ................................ ......... 16 Table 2: Visits and assessments schedule (Arm B: Docetaxel or Pemetrexed) ................. 18 Table 3: Dose Reduction for Pemetrexed – Hematologic Toxicities ................................ 66 Table 4: Dose Reduction for Pemetrexed – Non-hematologic Toxicities ......................... 66 Table 5: Dose Reduction for Pemetrexed - Neurotoxicity CTC Grade ............................. 67 Table 6: Summary of the Overall Response Status ................................