Wen PY, Macdonald DR, Reardon DA, et al. Updated response assessment criteria for high -grade gliomas: response assessment in neuro -oncology working group. J Clin Oncol 2010;28:1963-72. Protocol A pilot study to evaluate PBR PET as an indicator of inflammation in brain tumor patients treated with chemoradiation or immunotherapy. Version Date: June 20, 2018 36 APPENDIX A P ERFORMANCE STATUS CRITERIA ECOG Performance Status Scale Karnofsky Performance Scale Grade Descriptions Percent Description 0 Normal activity. Fully active, able to carry on all pre- disease performance without restriction. 100 Normal, no complaints, no evidence of disease. 90 Able to carry on normal activity; minor signs or symptoms of disease. 1 Symptoms, but ambulatory. Restricted in physically strenuous activity, but ambulatory and able to carry out work of a light or sedentary nature ( e.g., light housework, office work). 80 Normal activity with effort; some signs or symptoms of disease. 70 Cares for self, unable to carry on normal activity or to do active work. 2 In bed <50% of the time. Ambulatory and capable of all self-care, but unable to carry out any work activities. Up and about more than 50% of waking hours. 60 Requires occasional assistance, but is able to care for most of his/her needs. 50 Requires considerable assistance and frequent medical care. 3 In bed >50% of the time. Capable of only limited self -care, confined to bed or chair more than 50% of waking hours. 40 Disabled, requires special care and assistance. 30 Severely disabled, hospitalization indicated. Death not imminent. 4 100% bedridden. Completely disabled. Cannot carry on any self-care. Totally confined to bed or chair. 20 Very sick, hospitalization indicated. Death not imminent. 10 Moribund, fatal processes progressing rapidly. 5 Dead. 0 Dead.