(CSP) and will be shipped to different labs for research analysis as required. Blood will be collected on days 1 and 15 prior giving treatment, Additionally, when no treatment is being given, blood will be collected on day 8 and within day 21-28, and day 105. This could occur +/- 3 days for any time point. Tumor tissue (and also normal mucosa and skin tissue may be collected) biopsies will be collected on Day 1 and within Day 21-28 or at surgery. Day 1 tissues will be collected via biopsy in the clinic under local anesthesia for accessible tumors. This pre-treatment biopsy is mandatory for all patients. If tumors are not accessible in the clinic or a biopsy in the clinic is deemed unsafe by the investigator, Day 1 biopsies may be performed in the operating room under general anesthesia. For post-treatment biopsy (on day 21-28 biopsies), if the surgery is performed at the NIH Clinical Center or at Suburban Hospital, the tissue will be acquired from the operating room while the patient is under general anesthesia. If the surgery will be performed at an outside academic institution other than Suburban Hospital, then biopsies will be performed in the clinic setting under local anesthesia at the NIH Clinical Center. This could occur +/- 3 days for any time point and is optional.