- Hemoglobin > 8 g/dL (may be supported). • Renal: - Serum creatinine ≤ upper limit of institutional normal - GFR of at least 70 ml/min/1.73m2. • Hepatic: - Bilirubin ≤ 1.5 times upper limit of normal for age. - SGPT (ALT) ≤ 3 times institutional upper limit of normal for age. - SGOT (AST) ≤ 3 times institutional upper limit of normal for age. • Adequate cardiac function defined as: - ECHO Cardiogram with e jection fraction of > 45% by radionuclide angiogram or MUGA scan within normal limits - EKG without clinically significant arrhythmias. • Pulmonary: - DLCO, FEV1, FEC (diffusion capacity) > 50% of predicted (corrected for hemoglobin and alveolar volume ) - Crying Vital Capacity if too young to perform pulmonary function tests Re-MATC H Protocol Page 55 of 106 Version: 20180628 - Chest X -ray and pulse oximetry reading of > 93% in room air at rest and following a brisk 6 - minute exercise resulting in a target heart rate of at least 100/min if patient cannot perform well on pulmonary function test due to neurologic deficits. • Negative serum pregnancy test for females of child -bearing potential.