doi: 10.1097/ MD.0000000000013112 12. Zeng P, Shen D, Zeng CH, Chang XF, Teng GJ. Emerging opportunities for combining locoregional therapy with immune checkpoint inhibitors in hepatocellularcarcinoma. Curr Oncol Rep (2020) 22(8):76. doi: 10.1007/s11912-020-00943-6 13. Slovak R, Ludwig JM, Gettinger SN, Herbst RS, Kim SH. Immuno-thermal ablations - boosting the anticancer immune response. J ImmunoTher Cancer (2017) 5(1):78. doi: 10.1186/s40425-017-0284-8 14. Fei Q, Pan Y, Lin W, Zhou Y, Yu X, Hou Z, et al. High-dimensional single- cell analysis delineates radiofr equency ablation induced immune microenvironmental remodeling in pancreatic cancer. Cell Death Dis (2020) 11 (7):589. doi: 10.1038/s41419-020-02787-1 15.