Nidhi Shah Dr. Suchana Mara hatta Address for Correspondence Dr. Bibisha Baaniya Junior Resident, 2018 Batch Department of Dermatology and Venereology BPKIHS, Dharan Email. cul.bibisha@gmail.com Institutional email: o ffice. academics@bpkihs.edu SUMMARY OF POST GRADUATE THESIS P ROTOCOL 1. Study title : A comparative study to assess ef ficacy of Intralesional MMR (Measles, Mumps, Rubella ) vaccine and Intralesional Vitamin D3 in treatment of Warts 2. Name of the author : Dr. Bibisha Baaniya 3. Dep artment : Department of Dermatology and Venereology 4. Name of co- author : Dr. Nidhi Shah Associate Professor Department of Dermatology and Venereology 5. Name of Co -author : Dr. Suchana Marahatta , Associate Professor Department of Dermatology and Venereology 6. Email ID of the author and co -authors : cul.bibisha@gmail.com & nidhishah.md@gmail.com suchanamara hatta@yahoo.com 7. Rationale of the research : As per my literature search, 1. No previous studies on immunotherapy in wart have been conducted in our country 2. No comparative studies have been done to compare IL MMR and IL vitamin D3 in treatment of wart hen ce we aim to establish efficacy of each and compare the two in our country 8. Objectives : Primary Objective s: 1. To determine the efficacy of IL MMR vaccine in the treatment of Wart 2. To determine the efficacy of IL vitamin D in the treatment of wa rt 3. To compare the efficacy of IL MMR vaccine and IL Vitamin D Secondary Objective s: 1. To determine the frequency of patients with different types of warts visiting Dermatology outpatient department of BPKIHS 2. To determine the side effects of IL MMR vaccine and IL Vitamin D in treatment of wart 3. To determine Dermatology life quality index (DLQI) in wart patients. 9. Research Hypothesis : Null Hypotheses (H0): IL MMR vaccine is not better than IL Vitamin D in the treatment of wart Alternative hyp othesis: IL MMR vaccine is better than IL Vitamin D in the treatment of wart 10. Material & Methods: (a) Whether study i nvolves Human/animals or both : Human only (b) Population/ participants : Patients with warts visiting D ermatology outpatient department (c) Type of study design : Prospec tive comparative longitudinal Study (d) Setting : Outpatient Department of Dermatology and Venereology, BPKIHS (e) Sample Selection crit eria: (i) Inclusion Criteria : 1. Clinically diagnosed patients who have more than three warts or single wart in difficult to treat sites (periungual, palms and soles) 2. Age > 12 years (ii) Exclusion Criteria : 1. Patients not under any systemi c or topical treatment of warts for the last four weeks 2. Patients with a past history of an allergic response to MMR or any other vaccine or Vitamin D 3. Patients with current acute febrile illness or any bacterial infection 4. Immunosuppressed patients 5. Pregnant or lactating women 6. Patients having a past history of asthma, allergic skin disorders or convulsions 7. Patients with keloidal tendency 8. Patient refusal for consent 9. Treating physician’s decision to give other treatment modality 10. Patients with hypervitaminosis D, muscle weakness, bone pain, altered sensorium (f) Expected sample size : 60 (30 in each group) (g) Control groups : not applicable (h) Probable duration of study : one year (i) Parameter/Variables to be measured: Age, sex, race, occupation, number of warts, site of warts, response rate, DLQI (j) Outcome measures : Response rate of warts to IL MMR and IL Vitamin D3 (k) Statistical methods to be employed : a. Data handling: Data were entered in Microsoft Excel 2010 (Microsoft Corporation, Redmond, Washing ton, USA) and statistical analysis was done using Statistical Package for the Social Sciences 10.5 version (Chicago, Inc) b.