Vaccinia -experienced (previous smallpox vaccination). 7. ECOG Performance Score of 0 or 1. 8. Life expectancy ≥ 1 year. 9. Bone Marrow function: • Absolute neutrophil count ≥ 1,500/mm3 • Hemoglobin ≥ 10 g/dL • Platelet count ≥ 100,000/mm3 10. Hepatic Function: • AST and ALT ≤ 2.5 times upper limit of normal (ULN) • Bilirubin ≤ 1.5 times ULN 11. Renal Function: • Creatinine ≤ 2.0 times ULN 12. Currently using a GnRH agonist or antagonist (unless surgically castrated). 4.7 Exclusion Criteria Subjects with any of the following will be excluded from enrollment: 1. Cancer -related pain requiring scheduled opioid narcotics for control (as needed, ≤ 2x per week is allowed). 2.