90 22. DATA MANAGEMENT .........................................................................................91 22.1 Data Management and Quality Control ....................................................... 91 22.2 Laboratory Data Transmission and Accountability ..................................... 91 23. DATA AND SAFETY MONI TORING PLAN .....................................................91 23.1 Data Safety Monitoring Board ..................................................................... 91 23.2 Independent Medical Monitor ...................................................................... 91 23.3 Independent External Monitor ..................................................................... 92 23.4 Principal Investigator ...................................................................................