Schedule of therapeutic agents administered will be as outlined in S ection 3.1, Figure 19.. NHS -IL12 will be given every 4 weeks , M7824 infusion will be every two weeks and HPV vaccine will be given every 4 weeks for the first 6 doses followed by every 12 weeks thereafter. (The first administration of HPV vaccine should preferably be given 1- 2 weeks before the first administration of NHS -IL12 and M7824.) Administration of study agents and indicated evaluations can be done up to 14 days earlier or delayed up to 14 days due to holidays, inclement weather, conflicts, or similar reasons. The timing of subsequent administrations is adjusted to maintain a minimum of 11 days between treatments of similar agents.