Who will bear the cost of the requir ements? Patient 18. ANNEXURE: a. Participants record form (clinical data sheet ): Attached b. Participant Information sheet i. Attached English c. Participant Informed consent form i. Attached English ABBREVIATION S ANOVA - Analysis of Variance BCG - Bacillus Calmette Guerin BPKIHS - BP Koirala Institute of Health Sciences DLQI - Dermatology Life Quality Index DNA - Deoxyribonucleic Acid DNCB - Dinitrochlorobenzene DPCP - Diphenylcyclopropenone G - Gauze HPV - Human Papilloma Virus IOE - Institute of Medicine IFN - Interferon IL - Intralesional, Interleukin IRC - Institutional Review Committee MD - Doctor of Medicine MMR - Measles, Mumps, Rubella NA - Not applicable NHRC - Nepal Health Research Council NK - Natural Killer OPD - Outp atient Department QoL - Quality of Life RCT - Random Control Trial SADBE - Squaric acid dibutyl ester TEIB - Triethyleneiminobenoquinone Th - T- helper TLR - Toll like receptor VAS - Visual Analogue scale VDR - Vitamin D receptor VDRA - Vitamin D r eceptor activator TABLE OF CONTENTS INTRODUCTION ................................ ................................