IRB # 12367 Version Date: 10/24/17 Version: 09 CIT Y OF HOPE NATIONAL MEDICAL CENTER 1500 E. DUARTE ROAD DUARTE, CA 91010 DEPARTMENT OF MEDICAL ONCOLOGY AND THERAPEUTICS RESEARCH TITLE: RANDOMIZED PHASE II TRIAL OF SIPULEUCEL T IMMUNOTHERAPY PRECEDED BY SENSITIZING RADIATION THERAPY AND SIPULEUCEL-T ALONE IN PATIENTS WITH CASTRATE RESISTANT METASTATIC PROSTATE CANCER CITY OF HOPE PROTOCOL NUMBER: #12367 VERSION: 09 DATE(S) OF AMENDMENT(S)/REVISION(S): Initial Approval Protocol Dated 02/01/2013 Version 00 Amendment 01 Protocol Dated 05/06/13 Version 01 Amendment 02 Protocol Dated 06/05/13 Version 02 Amendment 03 Protocol Dated 07/18/13 Version 03 Amendment 04 Protocol Dated 08/12/13 Version 04 Amendment 05 Protocol dated 10/08/13 Version 05 Amendment 06 Protocol dated 12/11/13 Version 06 Amendment 07 Protocol dated 01/24/14 Version 07 Amendment 08 at Continuation Protocol dated 01/10/17 Version 08 Amendment 09 Protocol dated 10/24/17 Version 09 DISEASE SITE: PROSTATE CANCER STAGE (if applicable): IV MODALITY: Immunotherapy and Radiation Therapy PHASE/TYPE: II/Randomized PRINCIPAL INVESTIGATOR: Cy Stein M.D. CO-PRINCIPAL INVESTIGATOR: Neeraj Agrawal M.D.