Se pte m ber 1 9 , 2 0 1 8 Pa ge | 2 4 8. Has k n o w n acti ve ce ntr al ner v o us s yste m ( C N S) metastases a n d/ or carci n o mat o us me ni n gitis. S u bjects wit h pre vi o usl y treat e d brai n metastases ma y partici pate pr o vi de d t he y ar e sta ble ( wit h o ut e vi de n ce of pr o gr essi o n b y i ma gi n g f or at least 2 wee ks pri or t o t he first d ose of trial tr eat me nt a n d a n y ne ur ol o gi c s y m pt o ms ha ve ret ur ne d t o baseli ne), h a ve n o e vi de nce of ne w or e nlar gi n g brai n metastases, a n d are n ot usi n g ster oi ds f or at least 7 da ys pri or t o trial treat me nt. T his e x ce pti o n d oes n ot i ncl u de car ci n o mat o us me ni n gitis w hic h is e x cl u de d re gar dless of cli nical sta bilit y.