* Highly Effective Contraceptive Methods That Are User Dependent Failure rate of <1% per year when used consistently and correctly. a •Combined (estrogen- and progestogen-containin g) hormonal contraception associated with inhibition of ovulationb −oral −intravaginal −transdermal •Progestogen -only hormonal contraception associated with inhibition of ovulationb −oral −injectable Revised Protocol No.: 04 Date: 31-May-2019 178 Approved 5.0 v Approved 1.0 v Clinical Protocol CA021002 BMS-986226 anti-ICOS Highly Effective Methods That Are User Independent •Implantable progestogen-only hormonal contraception associated with inhibition of ovulation b •Hormonal methods of contraception including vaginal ring, injectables, implants and intrauterine hormone-releasing system (IUS)c •Intrauterine device (IUD)c •Bilateral tubal occlusion •Vasectomized partner A vasectomized partner is a highly effective contraception method provided that the partner is the sole male sexual partner of the WOCBP and the absence of sperm has been confirmed. If not, an additional highly effective method of contraception should be used.