679095 6. Brahmer JR, Drake CG, Wollner I et al (2010) Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refrac- tory solid tumors: safety, clinical activity, pharmacodynamics, 2056 Cancer Immunology, Immunotherapy (2023) 72:2045–2056 1 3 and immunologic correlates. J Clin Oncol 28:3167–3175. https:// doi. org/ 10. 1200/ jco. 2009. 26.