HS - 130 and HS -110 will be temporarily stopped for the period of time these m edications are used. • Immunosuppressive agents, except to treat a drug- related adverse event • Systemic corticosteroids > 10 mg daily prednisone equivalent Ocular, intra -articular, intranasal, and inhalational corticosteroids are allowed. 6.5 Monitoring Subject Compliance This study will be monitored by Heat Biologics or its CRO acco rding to ICH E6 guidelines of GCP.