Reports will be made per the requirements of section 7.2. 49 Abbreviated Title: Neoadjuvant IO for HNSCC Version Date: August 31, 2022 5.3 SAMPLES FOR GENETIC/GENOMIC ANALYSIS 5.3.1 Description of the scope of genetic/genomic analysis Using blood and tissue samples, we will perform next generation sequencing (NGS) of DNA and RNA. This will be performed by Nant.