The se cohorts will allow certain standard, relatively non -toxic therapies to continue while patients receive vaccine. • Up to 18 patients may be required to be enrolled in the 3 cohorts, plus an additional 10 at the MTD and at the dose level just below it. Thus, up to 38 patients may be theoretically required to complete this trial. If 3 patients per month can be accrued, the study is expected to require 1 year to complete the necessary enrollment. 5 Abbreviated Title: Phase I MVA -Brachyury -TRICOM Version Date: September 14, 2016 Confidential TABLE OF CONTENTS PRÉCIS ........................................................................................................................................... 3 1.