Strictly adhere to standard microbiological practices and techniques. 2. Limit/restrict access to preparation areas while dose preparation is in progress. 3. Use appropriate infection control measures (e .g., thorough hand washing) after handling any materials. 4. Institute and follow policies for safe handling of sharps.5. Perform all dose preparations in a certified Class II biological safety cabinet, generally using procedures, guidelines and personal protective apparel used during preparation of antineoplastic agents [ e.g., minimizing creation of aerosols; no eating, drinking, handling contact lenses or applying cosmetics in the work area; using appropr iate personal protective apparel - gowns, sterile latex gloves (double-gloving is reco mmended), respirator masks, protective eye wear, hair cover]. Version Date: 12/5/17 Abbreviated Title : Enzalutamide in non-met CSPC 566. Decontaminate the biological sa fety cabinet prior to dose prepar ation with sterile gauze soaked in 10% bleach solution (0.52% sodium hypochlorite solution), or other appropriate disinfectant suitable for decontamination, rinsing, then wi ping down with sterile gauze soaked in 70% alcohol. Consult specific manufacturer’s reco mmendations with respect to disinfectant concentration, contact time and method of application. 7. Have all necessary supplies on- hand before beginning the preparation procedure. Develop a detailed worksheet outlining all supplies, dose calculations, and preparation procedures, and keep it available. 8. Place an empty biohazard sharps container lined with a leak-proof biohazard bag in or near the biosafety cabinet to dispose of all waste generated. 9. Transport the agent from the freezer to the work area in leak proof bag. 10. Wipe or spray items used for dose prepara tion with 70% alcohol before placing in the biological safety cabinet. Disi nfectants should remain in contact with the surfaces for at least five minutes prior to dose preparation. Avoid exposing the virus to disinfectants. 11. Wipe the syringe containing the prepared dos e with 70% alcohol before removing it from the biological safety cabinet; transport it in a leak proof bag or container labeled with a biohazard symbol. 12. Place all waste into the sharps container lined with the leak proof biohazard bag and decontaminate the biological safety cabinet again by wiping down all surfaces with sterile gauze soaked in 10% bleach solution, or other a ppropriate disinfectant, rinsing, then wiping down with sterile gauze soaked in 70% alcohol. Following decontamination, dispose of personal protective apparel in the biohazard safety bag. 13. Incinerate waste according to institutional policy and according to local, state, and federal regulations. 14. Handle accidental spills similarly to antineoplastic spills and/or according to institutional policy: xPrevent others from entering the area and allow aerosols time to settle (approximately 10 minutes). xUse protective apparel, eyewear, mask, and gloves. xCover spills with disposable absorbent towels. xDecontaminate the area with 10% bleach solutio n, or other appropriate disinfectant suitable for decontamination, allowing appr oximately a 20-minute contact time. xDispose of all waste as biohaza rdous waste and incinerate according to institutional policy and according to local, state, and federal regulations.