Wick W, Puduvalli VK, Chamberlain MC, van den Brent MJ, Carpentier AF, Cher LM, et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent i ntracranial glioma. J Clin Oncol 2010;28(7):1168-74. DocuSign Envelope ID: B3F56764-C440-4885-BA44-7578C4A73DB3 Stemline Therapeutics, Inc. Protocol: STML- 701-0114 Version 3.0, 10-JUL-2015 (Amendment 2) Statistical Analysis Plan Page 45 of 63 13. PROGRAMMING CONSIDERATIONS All tables, data listings, figures (TLFs), and statistical analyses will be generat ed using SAS® version 9.2 or higher (SAS® Institute Inc., Cary, NC, USA). Computer-generated table, listing and figure outputs are recommended to the following specifications. 13.1. TABLE, LISTING, AND FIGURE FORMAT The sections below are general recommended considerations. 13.1.1. General  All TLFs will be produced in landscape format, unless otherwise specified.  All TLFs will be produced using the Courier New font, size 8  The data displays for all TLFs will have a 1.5-inch binding margin on top of a landscape oriented page and a minimum 1-inch margin on the other 3 sides.  Headers and footers for figures will be in Courier New font, size 8.  Legends will be used for all figures with more than 1 variable, group, or item displayed.  TLFs will be in black and white (no color), unless otherwise specified  Specialized text styles, such as bolding, italics, borders, shading, and superscripted and subscripted text, will not be used in the TLFs, unless otherwise specified. On some occasions, superscripts 1, 2, or 3 may be used (see below).  Only standard keyboard characters will be used in the TLFs. Special characters, such as non- printable control characters, printer-specific, or font-specific characters, will no t be used. Hexadecimal-derived characters will be used, where possible, if they are appropriate to help display math symbols (e.g., μ). Certain subscripts and superscripts ( e.g., cm2, Cmax) will be employed on a case- by-case basis.  Mixed case will be used for all titles, footnotes, column headers, and programmer-supplied formats, as appropriate.