For Cycle 1 Day 1, these tests may be performed within 3 days. Tests done within 3 day s of Cycle 1 Day 1 do not need to be repeated unless clinically indicated. c: Vital signs, including blood pressure, heart rate, respiratory rate, and temperature. During Cycle 1 and Cycle 2 on Day 1: Before HS130/HS110 treatment; after treatment at 30 mins ( ±5min), 1hr (±5min). Other Cycles on Day 1: only Pre -dose. d: Standard 12 -lead ECG (in triplicate) while patient is in semi -recumbent position pre -dose on Day 1 of each cycle. e: Tumor measurement per RECIST 1.11. Patients will be evaluated at screening and then after every 8 -weeks ± 1 week from C1D1 until disease progression. f: Hematology, including hemoglobin, WBC with differential, and platelet count (Approximately 5 mL blood per draw). g: Blood chemistry, including sodium, potassium, BUN, glucose, SGOT/SGPT (ALT/AST), alkaline phosphatase, total protein, total bilirubin, albumin, lactate dehydrogenase (LDH), TSH, creatinine, C -reactive protein and calcium. (Approximately 5 mL blood per draw).