Ludwig Institute for Cancer Research Statistical Analysis Plan A Phase 1/2 Study of Combinati on Immun otherapy and mRNA Vaccine in Subj ects with Non-small Cell Lung Ca ncer (NSCLC) Protocol Number LUD2014 -012-VAC NCT03164772 Amendment 9.1, 01-SEP-2020 SAP Version 3.0 (09DEC2020) Prepared By: Advanced Clinical 10 Parkway North, Suite 350 Deerfield, IL 60015 TABLE OF CONTENTS 1.0 PURPOSE ................................ ................................