............................. 16 5.2 General Concomitant Medication and Supportive Care Guidelines ...................... 19 5.3 Prohibited and/or Restricted Medications and Devices ................................ ......... 22 5.4 Other Restrictions and Precautions ................................ ................................ ........ 23 5.5 Antibiotic Administration ................................ ................................ ...................... 24 5.6 Definition of an Overdose for this Protocol ................................ ........................... 25 5.7 Unacceptable Toxicity ................................ ................................