There is no plan to advertise this study at this time. 2.2 SCREENING EVALUATION 2.2.1 Screening activities performed prior to obtaining informed consent Prior to the subject signing the research consent, subjects may be contacted by several means (e.g., email, mail, in person or telephone) for consideration as a potential protocol candidate, as follows: Review of existing medical records, including medical history, physical evaluations, laboratory studies, etc. Review of existing MRI, x-ray, or CT images Review of existing photographs or videos Review of existing pathology specimens/reports from a specimen obtained for diagnostic purposes. 2.2.2 Screening activities performed after a consent for screening has been signed The following activities will be performed only after the subject has signed the consent for study 01-C-0129 on which screening activities will be performed. Note: Screening evaluation testing/procedures are conducted under the separate screening protocol, 01-C-0129 (Eligibility Screening and Tissue Procurement for the NIH Intramural Research Program Clinical Protocols). Screening tests and procedures must be performed within 28 days prior to initiation of study therapy, unless otherwise specified: Complete medical history and physical examination (including height, weight, vital signs, and ECOG performance status). Clinic-based flexible nasopharyngo-laryngoscopy and/or tracheoscopy to document disease to the extent that it can be evaluated without sedation or general anesthesia. This will include standard bright-light endoscopy and may include video-stroboscopy.