Protocol Version 8.0. September 19 , 2018 Page | 62 11.0 APPENDICES 11.1 ECOG Performance Status Grade Description 0 Normal activity. Fully active, able to carry on all pre -disease performance without restriction. 1 Symptoms, but ambulatory. Restricted in physically strenuous activity, but ambulatory and able to carry out work of a light or sedentary nature (e.g., light housework, office work). 2 In bed <50% of the time. Ambulatory and capable of all self -care, but unable to carry out any work activities. Up and about more than 50% of waking hours. 3 In bed >50% of the time. Capable of only limited self -care, confined to bed or chair more than 50% of waking hours. 4 100% bedridden. Completely disabled. Cannot carry on any self - care. Totally confined to bed or chair. 5 Dead. * As published in Am. J.