5.9.3 ECG ECG will be evaluated locally. Any clinically significant abnormal findings observed and recorded during the tr eatment period will be recorded as AEs. The same method of assessment should be used throughout. 5.9.4 Performance status Performance status will be evaluated locally using the ECOG scale: Grade ECOG 0 Fully active, able to carry on all pre -disease performance without restriction 1 Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work 2 Ambulatory and capable of all selfcare but unable to carry out any work act ivities. Up and about more than 50% of waking hours 3 Capable of only limited selfcare, confined to bed or chair more than 50% of waking hours 4 Completely disabled.