absence) - Pleura l metastases at study entry ( presence vs. absence ) - Number of different metastasis locations ( 0, 1, 2, ≥ 3 ) - Cancer staging at study entry (III vs. IV) - dNLR (derived Neutrophil s/(Leukocyte minus neutrophils Ratio)) at baseline (< 3 vs ≥ 3) - LDH Classification at baseline (<= upper limit of normal range (ULN), > ULN) - PDL1 (Positive, Negative, Unknown) OSE Immunotherapeutics v2.2 Study OSE2101C301 (ATALANTE 1) Statistical Analysis Plan 2021 -07-23 IND#: BB-IND 10802 CONFIDENTIAL P a g e | 22/51 - Albumin Classification at baseline (<35g/l, ≥35g/l) *: only in ITT or PP population s and not in ITT_ PoI or PP_ PoI 'dNLR (derived Neutrophils/(Leukocyte minus neutrophils Ratio))' must be read as 'dNLR (derived Neutrophils/(Leukocyte minus Neutrophils) Ratio)' Additional subgroups will be explored in the ancillary SAP. 7.3.