cn/ gsa. Declarations Ethics approval and consent to participate This study was performed in agreement with the Declaration of Helsinki and the International Conference on Harmonization Guidelines for Good Clinical Practice, and approved by the Institution Review Board of Mengchao Hepato - biliary Hospital of Fujian Medical University (Fujian, China). Consent for publication Written informed consent was obtained from the patients for publication of this letter. Page 13 of 13 Cai et al. Molecular Cancer (2021) 20:164 • fast, convenient online submission • thorough peer review by experienced researchers in your ﬁeld • rapid publication on acceptance • support for research data, including large and complex data types • gold Open Access which fosters wider collaboration and increased citations maximum visibility for your research: over 100M website views per year • At BMC, research is always in progress. Learn more biomedcentral.com/submissionsReady to submit y our researc h Ready to submit y our researc h ? Choose BMC and benefit fr om: ? Choose BMC and benefit fr om: Competing interests The authors have no conflicts of interest to declare. Author details 1 The United Innovation of Mengchao Hepatobiliary Technology Key Labora- tory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou 350025, Fujian Province, People’s Repub - lic of China. 2 The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, People’s Republic of China. 3 Mengchao Med- X Center, Fuzhou University, Fuzhou 350116, People’s Republic of China. 4 Department of Gastro - enterology, Second Affiliated Hospital of Wenzhou Medical University, Wen- zhou 325000, People’s Republic of China. 5 School of Basic Medicine, Wenzhou Medical University, Wenzhou 325000, People’s Republic of China. Received: 16 September 2021 Accepted: 22 November 2021 References 1. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, et al. Cancer statis- tics in China, 2015. CA Cancer J Clin. 2016;66:115–32. 2.