Bavarian Nordic , Inc. Statistical Analysis Plan Amendment 1 Protocol: BNIT -PRV -301 Date Issued: 29 June 2015 Conf idential Sta tistical Analysis Plan Amendment 1 29 June 2015 BNIT -PRV -301 A R andomized, Double -blind, Phase 3 Efficacy Trial of PROSTVAC VF ± GM- CSF in Men With Asymptomatic or Minimally Symptomatic Metastatic, Castrate -Resistant Prostate Cancer Bavarian Nordic, Inc. Bavarian Nordic, Inc. Statistical Analysis Plan Amendment 1 Protocol: BNIT -PRV -301 Date Issued: 29 June 2015 C onfidential ii Revised: June 2015 TABLE OF CONTENTS List of Abbreviations ...................................................................................................................... v 1.