•If it is determined that the participant has died, the site w ill use permissible local met hods to obtain date and cause of death. •If investigator’s use of third-party representative to assist in the follow-up portion of the study has been included in the participant’s informed consent, then the investigator may use a -retained third-party representative to assist site staff with obtaining the participant’s contact information or ot her public vital status data necessary to complete the follow-up portion of the study. •The site staff and representative will consult publicly available sources, such as public h ealth registries and databases, to obtain updated contact information. •If after all attempts the participant remains lost to follow-up, then the last known alive date, as determined by the investigator, should be reported and documented in the participant’s medical records. 9 STUDY ASSESSMENTS AND PROCEDURES •Study procedures and timing are summarized in the Schedule of Activities ( Section 2 ).