10 Figure 2. Highly reactive transferred cells traffic to brain and destroy tumor deposit in melanoma patients. .............................................................................................................................................................. 11 Figure 3. Host -derived antitumor T cells treat lesions in the brain. ............................................................. 11 Figure 4. Genetically engineered antitumor T cells treat lesions in the brain ............................................. 12 Figure 5. Tetanus pre conditioning, imiquimod and GM- CSF increases the number of IDH1 mutant specific T cells after vaccination. .......................................................................................................................