3. Treatment: • Trial treatment will be given with either HPV vaccine monotherapy (Arm 1A) or the combination of HPV vaccine + M7824 (Arm 1B) for a year. • HPV vaccine will be given on D1, D15 and D29 followed by every 4 weeks thereafter and M7824 will be given every 2 weeks. • Both of these agents may be discontinued early for unacceptable toxicity or disease progression.