........ 80 APPENDIX 1: ECOG PER FORMANCE STATUS SCAL E ................................ ....................... 82 APPENDIX 2: GRADING SCALE FOR INJECTION SITE REACTIONS ............................... 83 APPENDIX 3: THE RESPONSE EVALUAT ION CRITERIA IN SOLI D TUMORS (RECIST 1.1) GUIDELINES AND GUIDL ELINES FOR RESPONSE CRITERIA FOR USE IN TRIALS TESTING IMMUN OTHERAPEUTICS (IRECIST) ................................ ................................