Days to be presented to 0 decimal places. 5.12 Statistical software Medidata Rave will be used as the Electronic Data Capture (EDC) system for the trial. SAS 9.4 will be used to generate data listings and summary tables/graphs. 5.13 Supplementary analysis – Pharmacodynamics (data collected outside of the clinical database) Pharmacodynamic anal yses will be described in supplementary lab report s . There are no primary endpoint pharmacodynamic assays for this study. 5.13.1 HLA Pre-screening DNA extracted from whole blood taken at pre -screening will be analysed by Luminex (or similar method) for HLA-A*02:01 allelic string (HLA population) . The whole A* allele will be reported for each patient. Results are reported per patient with in 14 days of receipt of the sample . The HLA-A*02:01 status (positive or negative) is also captured in the clinical database on the enrolment eCRF. SM.TEMP.013 version 5 CRUKD/17/003 RAP Version: 2.0 09Mar2023 FINAL 22 The final report is expected no more than two months after completion .