NL76095.042.20 / VOICE 1 Vaccination against cOvid In CancEr (December 2021 ) NL76095.042.20 / VOICE 2 PROTOCOL TITLE : VOICE Vaccination against cOvid In CancEr Protocol ID Will be submitted to Clinical Trials.gov. Short title VOICE Version 6.0 Date 27 December 2021 Project leader E.G.E. de Vries, MD , PhD, medical oncologist Department of Medical Oncology University Medical Center Groningen E-mail: e.g.e.de.vries@umcg.nl Principal investigator(s) (in Dutch: hoofdonderzoeker/ uitvoerder) A.A.M. van der Veldt, MD , PhD, medical oncologist Departments of Medical Oncology and Radiology & Nuclear Medicine Erasmus MC -Cancer Institute, Rotterdam E-mail: a.vanderveldt@era smusmc.nl J.B.A.G. Haanen, MD , PhD, medical oncologist Department of Medical Oncology, Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam E-mail: j.haanen@nki.nl S.F. Oosting, MD , PhD, medical oncologist Department of Medical Oncology University Medical Center Groningen E-mail: s.oosting@umcg.nl Writing committee / Investigators VOICE Consortium UMCG, Groningen D. van Baarle, PhD, immunologist Department of Medical Microbiology and Infection Prevention E-mail: d.van.baarle@umcg.nl NL76095.042.20 / VOICE 3 M. Jalving, MD, PhD, medical oncologist Department of Medical Oncology E-mail: m.jalving@umcg.nl R.S.N. Fehrmann, MD, PhD, medical oncologist Department of Medical Oncology E-mail: r.s.n.fehrmann@umcg.nl T.J.N. Hiltermann, MD, PhD, pulmonologist Department of Pulmonary Diseases E-Mail: t.j.n.hiltermann@umcg.nl Erasmus MC, Rotterdam C. Geurts van Kessel, PhD, clinical virologist Department of Viroscience E-mail: c.geurtsvankessel@erasmusmc.nl M.P.G. Koopmans, PhD, virologist Department of Viroscience E-mail: m.koopmans@erasmusmc.nl A.C. Dingemans, MD, PhD, pulmonologist Department of Respiratory Medicine E-mail: a.dingemans@erasmusmc.nl NKI-AvL, Amsterdam P. Kvistborg, PhD, scientist Department of Molecular Oncology and Immunology E-mail: p.kvistborg @nki.nl NL76095.042.20 / VOICE 4 C.U. Blank, MD, PhD, medical oncologist Department of Medical Oncology E-mail: c.blank@nki.nl E.F. Smit, MD, PhD, pulmonologist Department of Thoracic Oncology E-mail: e.smit@nki.nl RIVM National Institute for Public Health and the Environment C.A.C.M. van Els, PhD, vaccinologist E-mail: cecile.van.els@rivm.nl N.Y. Rots, PhD, scientific advisor E-mail: nynke.rots@rivm.nl Sponsor (in Dutch: verrichter /opdrachtgever ) University Medical Center Groningen Hanzeplein 1 9713 GB Groningen The Netherlands Subsidizing party ZonMW Independent expert G.A. Huls, MD PhD Department of Hematology University Medical Center Groningen E-mail: g.huls@umcg.nl Laboratory sites Fiona van der Klis, Center for Infectious Disease Control , RIVM Debbie van Baarle, Medical Microbiology and Infection Prevention, UMCG Corine Geurts van Kessel, Department Viroscience, Erasmus MC NL76095.042.20 / VOICE 5 Pia Kvistborg, Department of Molecular Oncology and Immunology, NKI-AvL D. van den Broek PhD, Head Clinical Laboratory, NKI - AVL. E-mail: d.vd.broek@nki.nl NL76095.042.20 / VOICE 6 PROTOCOL SIGNATURE SHEET Name Signature Date Head of Department: J.A. Gietema, MD, PhD Project leader : E.G.E. de Vries, MD, PhD NL76095.042.20 / VOICE 7 TABLE OF CONTEN TS 1. INTRODUCTION AND RATIONALE ................................ ................................