All research activities will be conducted in as private a setting as possible. 73 Abbreviated Title: Neoadjuvant IO for HNSCC Version Date: August 31, 2022 The study monitor, other authorized representatives of the sponsor, representatives of the Institutional Review Board (IRB), and/or regulatory agencies may inspect all documents and records required to be maintained by the investigator, including but not limited to, medical records (office, clinic, or hospital) and pharmacy records for the participants in this study. The clinical study site will permit access to such records.