Dr. Friedman is a highly experienced neurosurgeon specializing in the care of patients with malignant brain tumors. As Co- Director of the Preston Wells Center with Dr. M itchell, his major interests are in the advancement of novel therapeutics for pediatric and adult patients with malignant brain tumors. Dr. Friedman’s role will be to facilitate the utilization of the vast financial, physical, and environmental resources within the Department of Neurosurgery and Preston Wells Brain Tumor Center in support of this protocol. He will meet regularly with Dr. Re-MATC H Protocol Page 34 of 106 Version: 20180628 Mitchell in the coordination of this study and ensure that all institutional resources are leveraged appropriately. Dr. Friedman is also actively overseeing the partnership with the Orlando Regional Medical Center’s neurosurgical practices and thus will be able to assist in the recruitment and enrollment of subjects from the ORMC network. Additionally, Dr. Friedman will e nsure that the clinical research and regulatory staff of the department are available in support of this protocol including requisite CRC, regulatory, administrative, and nursing support. Dr. Mitchell and Friedman are coordinately responsible for staffing any additional specialized needs in support of the research mission of the Preston A. Wells, Jr.