CONFIDENTIAL CRUKD/17/003 Protocol Final 5.0 dated 08Jun2021 Page 1 of 72 EudraCT number : 2016 -002577 -35 Cancer Research UK CANCER RESEARCH UK Centre for Drug Development A Cancer Research UK Phase I trial of AST-VAC2 ( allogeneic dendritic cell vaccine) administered weekly via intradermal injection in patients with advanced non-small cell lung cancer . Sponsor protocol number: CRUKD/17/003 EudraCT number: 2016 -002577- 35 Chief Investigator: Professor Christian Ottensmeier Sponsor: Cancer Research UK CONFIDENTIAL CRUKD/17/003 Protocol Final 5.0 dated 08Jun2021 Page 2 of 72 EudraCT number : 2016 -002577 -35 Cancer Research UK PARTICIPA TING INVESTIGATORS AND CENTRES: Details of Principal Investigators and Investigational Sites are recorded on the Participating Investigators and Centres list in the Sponsor’s Trial Master File. VERSION HISTORY: Version No.