5.2.7. Missing, Unused and Incomplete Data All AEs with partial/missing onset dates will be considered treatment -emergent adverse events ( TEAEs ) unless a partial date clearly indicates that it occurred prior to first dose of study treatment or more than 28 days after the last dose of study treatment . Start dates with a missing day but which have month and year populated will be imputed such that: • If the provided month and year match the month and year for that subject’s first dose date, then the first dose date will be used. • In all other cases, the 1st of the month will be used with the provided month and year. Start dates with a missing day and month but which have year populated will be imputed such that: • If the provided year matches the year for that subject’s first dose date, then the first dose date will be used. • In all other cases the 1st of January will be used with the provided year. If the start date is completely missing then the date will be assumed as the subject’s first dose date and the event will be considered as treatment emergent, unless the stop date indicates that the event ended prior to first dose date. No imputation will be performed for subjects who did not receive study treatment. In those cases, the start date will be counted as missing. Stop dates will be imputed as follows: • Missing day with a provided year and month will use the last day of the month. • Missing day and month with provided year will use December 31. Aduro Biotech, Inc. CONFIDENTIAL Protocol ADU -CL-02 Final Version 1 Page 16 of 24 04MAY2018 • Completely missing stop dates will be treated as missing and no imputation will be done. If the imputed stop date is greater than the last known date for the subject ( e.g., date of last contact, date of death) then the imputed date will be replaced with the last known date. Similar rules will be used for prior/ concomitant medications with incomplete or missing start or stop dates. In order to calculate time from diagnosis , partial dates will be imputed. Missing months will be assumed as July. Missing days will be assumed as the 1 st of the month. If the entire diagnosis date is missing, then no imputation will be performed. No additional imputation for other missing data is planned. Missing values will be listed as represented in the clinical database (e.g. ‘NR’ (not reported), blanks).