Pruritus 3 6 3 . . Rash 2 4 1 1 . Rash/desquamation 1 2 1 . . Wound, noninfectious 4 8 4 . . Endocrine 2 4 . . Endocrine, other 1 2 1 . . Hyperthyroidism 1 2 1 . . Gastrointestinal 26 51 23 3 . Anorexia 11 22 9 2 . Constipation 1 2 1 . Diarrhea patients without colostomy 5 10 5 . . Flatulence 1 2 1 . . Gastrointestinal, other 1 2 1 . . Heartburn 2 4 2 . . Mouth dryness 1 2 1 . . Mucositis, oral cavity 2 4 2 . . Nausea 14 27 12 2 . Stomatitis/pharyngitis 3 6 3 . . Vomiting 3 6 3 . . Hemorrhage 2 4 2 . . Hemorrhage pulmonary, nose 1 2 1 . . Rectal bleeding/hematochezia 1 2 1 . . Hepatic 7 14 6 1 . Alkaline phosphatase 4 8 4 . . SGOT (AST) 3 6 3 . . SGPT (ALT) 2 4 1 1 . Infection/Febrile Neutropenia 2 4 . 2 . Infection, cellulitis 1 2 . 1 . Infection without neutropenia 1 2 . 1 . Lymphatics 6 12 6 . . Edema: limb 4 8 4 . . Lymphatics 1 2 1 . . Lymphatics, other 3 6 3 . . Metabolic/Laboratory 27 53 21 6 . Creatinine 2 4 . 2 . GFR 1 2 1 . . Hyperglycemia 19 37 16 3 . Hyperkalemia 1 2 1 . . Hypernatremia 1 2 1 . . Hypocalcemia 2 4 2 . . Hypoglycemia 4 8 4 . . Hypokalemia 2 4 2 . . Hypomagnesemia 3 6 3 . . Hyponatremia 1 2 1 . . Hypophosphatemia 1 2 . 1 . NCI Protocol #: CITN-04 Version Date: 27 Jan 2016 45 Description N %Grade, n 1 2 3 Metabolic/Lab, other 1 2 1 . . SGPT (ALT) 1 2 1 . . Musculoskeletal 5 10 4 1 . Musculoskeletal, other 5 10 4 1 . Neurology 13 25 10 3 . CNS ischemia 1 2 . 1 . Confusion 1 2 1 . . Dizziness 5 10 4 1 . Dizziness/lightheadedness 3 6 3 . . Memory loss 1 2 1 . . Mood alteration, agitation 1 2 1 . . Mood alteration, anxiety 1 2 . 1 . Mood alteration, depression 1 2 1 . . Neuropathy, sensory 2 4 2 . . Syncope (fainting) 2 4 2 . . Ocular/Visual 3 6 3 . . Dry eye 1 2 1 . . Ocular, other 2 4 2 . . Ocular surface disease 1 2 1 . . Pain 40 78 27 13 . Arthralgia (joint pain) 17 33 14 3 . Headache 24 47 21 3 . Myalgia (muscle pain) 24 47 15 9 . Pain, abdomen NOS 1 2 1 . . Pain, back 3 6 3 . . Pain extremity, limb 2 4 2 . . Pain, throat/pharynx/larynx 1 2 1 . . Pain, other 5 10 4 1 . Pulmonary 12 24 6 4 2 Cough 7 14 5 2 . Dyspnea (shortness of breath) 6 12 3 1 2 Pneumonitis 1 2 . 1 . Pulmonary, other 2 4 2 . . Voice changes/strider/larynx 3 6 3 . . Renal/Genitourinary 3 6 3 . . Creatinine 2 4 2 . . Renal, other 1 2 1 . . Sexual/Reproductive Function 1 2 . 1 . Vaginitis 1 2 .