brain MRI, bone scan. x A 5-liter apheresis may be performed. If th e patient is unable to undergo apheresis, approximately 96 mL of blood may be obtained. This will be performed on protocol 03- C-0277. 3.6.2 Subsequent Follow-up Evaluations All patients will return to the NIH Clinical Ce nter for their second follow-up evaluation one month (± 5 days) after the first follow-up evalua tion. Subsequent follow-up evaluations will take place every 1-2 months for the first year, and then annually for up to five years or until clinically proven progressive disease, whichever comes first. Patients will be co-enrolled and followed on the NCI-SB long-term follow-up protocol 09-C-0161 (Follow-up Protocol for Subjects Previously Enrolled on NCI Surgery Branch Studies). As noted in Section 3.6.1, additional Abbreviated Title: mRNA-Based, Cancer Vaccine Version Date: January 23, 2019 30 apheresis may be performed only at the first follo w-up evaluation. It will not be performed at any other post-treatment evaluations.