Age >18 years 9. Stable c reatinine < 2.0mg/dL, or creatinine cl earance > 60ml/min . Laboratory tests should be performed within 60 days of enrollment. 10. Serum bilirubin < 1.5 mg/dl . Laboratory tests should be performed within 60 days of enrollment. 11. SGOT < 2x ULN. Laboratory tests should be performed within 60 days of enrollment. 12. Subjects must have recovered from major infections and/or surgical procedures and, in the opinion of the investigator, not have a significant active concurrent medical illness precluding protocol treatment or survival. 13. Patients must have a baseline LVEF measured by MUGA equal to or greater than the lower limit of normal for the radiology facility and if there are two consecutive MUGAS performed while on trastuzumab from the same radiology facility, there cannot be a decrease in LVEF of > 15% from the original MUGA scan. B.