To respect patient conﬁdentiality, access to the data will be obtained by forma l applicationtoaDataAccessCommitteethatrequiresresearch ers tosignaDataAccessAgreement(DAA). AUTHOR CONTRIBUTIONS MB-S is responsible for the development of NeoDisc and for clinicalantigendiscovery,andwrotethemanuscript.BSand FH developedNeoDisc.JMandHPperformedBristol-MyersSquibb (BMS) immunopeptidomics experiments. JR and DG developed MixMHC2perd.CS,DW,andNDprovidedthepancreaticcancer specimens and reviewed the manuscript. AD, KB, and SM contributed to the clinical trial design and manuscript writ ing. GC contributed to the clinical trial design. A-CT and AH developed the immunogenicity validation data. CB developed the vaccine clinical grade data. LK developed the clinical gra de vaccine,conceivedtheclinicalstudy,andwrotethemanusc ript. FUNDING This work was partially supported by the Ludwig Institute for Cancer Research (MB-S, HP, JM, FH, DG, JR, AH, and LK), the ISREC Foundation thanks to a donation from the Biltema Foundation (MB-S, HP, JM, FH, and AH), and institutional support from Center Hospitalier Universitaire Vaudois. The clinical study will be ﬁnancially supported by Bristol-Myers Squibb(BMS). SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.338 9/ﬁmmu. 2019.01832/full#supplementary-material Table S1 | General clinical information and high resolution HLA typin g. Table S2 | List of HLA-I and HLA-II peptides identiﬁed by MS-based immunopeptidomics in the three PDAC tumor samples, includi ng MS intensity, peptide length and mass, identiﬁcation score and posterior e rror probability (PEP), source proteins and gene names. Frontiers in Immunology | www.frontiersin.org 13 August 2019 | Volume 10 | Article 1832 Bassani-Sternberg et al. Personalized Vaccine for Pancreatic Cancer REFERENCES 1. BrayF,FerlayJ,SoerjomataramI,SiegelRL,TorreLA,JemalA.Globa lcancer statistics2018:GLOBOCANestimatesofincidenceandmortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. (2018) 68:394–424. doi:10.3322/caac.21492 2. Huang L, Jansen L, Balavarca Y, Babaei M, van der Geest L, Lemmen s V, et al. Stratiﬁed survival of resected and overall pancreatic canc er patients in Europe and the USA in the early twenty-ﬁrst century: a large, international population-based study. BMC Med.