Protocol BNIT -PRV-301; Amendment 7 PROSTVAC -V/F Version 2.7, 08 February 2017 CONFIDENTIAL AND RESTRICTED 1 Amend 7 Disclosure requires written consent from Bavarian Nordic , Inc. Protocol Title A Randomized, Double -blind, Phase 3 Efficacy Trial of PROSTVAC -V/F ± GM -CSF in Men With Asympto matic or Minimally Symptomatic Metastatic, Castrate -Resistant Prostate Cancer Protocol Number BNIT -PRV-301 IND No. / OBA Protocol Number BB-IND 13946 / # 1104 -1101 NCT Number: NCT01322490 EudraCT No. 2010 -021196 -85 Investigational Product PROSTVAC -V/F Sponsor Bavarian Nordic , Inc. CRO Medical Monitor Drug Safety Bavarian Nordic, Inc. Study Protocol Protocol BNIT -PRV- 301; Amendment 7 PROSTVAC -V/F Version 2.7, 08 February 2017 CONFIDENTIAL AND RESTRICTED 3 Amend 7 Disclosure requires written consent from Bavarian Nordic , Inc. TABLE OF CONTENTS TABLE OF CONTENTS ..................................................................................................