Memorial Sloan Kettering Cancer Center IRB Number: 17- 358 A(7) Approval date: 25 -Feb-2022 MSK Protocol Cover Sheet A Safety Study of Avelumab plus SBRT in Malignant Mesothelioma (MPM) Principal Investigator: Andreas Rimner, MD in the Department of Radiation Oncology Memorial Sloan Kettering Cancer Center 1275 York Avenue New York, New York 10065 Page 1 of 51 Version: 2/26/16 Memorial Sloan Kettering Cancer Center IRB Number: 17- 358 A(7) Approval date: 25 -Feb-2022 Page 5 of 51 Table of Contents 1.0 PROTOCOL SUMMARY AND/OR SCHEMA .................................................................................8 2.0 OBJECTIVES AND SCIENTIFIC AIMS .............................................................................. 10 3.1 BACKG ROUND AND RATIONALE ..................................................................................