Known or clinically suspected leptomeningeal disease. Stable, previously treated met astases in the brain or spinal cord, are allowed as long as these are considered stable (by CT or MR I), and not requiring systemic corticosteroids. Heat Biologics Protocol No. HS130 -001 A Phase I Study of HS -130 in combination with HS-110 in patients with solid tumors HS130- 001 28 of 60 Version 2.0 - 11 Feb 2020 Confidential - Entire Page 3. History of ≥ grade 3 allergic reactions as well as known or suspected allergy or intolerance to any agent given in the course of this trial, live cell therapies, or live vaccines. 4. History of suspected cytokine release syndrome (CRS). 5. Known immunodeficiency disorders (testing not required) . 6.