Consider pulmonary and Infectious Disease consults. Consider 1.0 to 2.0 mg/kg/day prednisone or equivalent Consider adding prophylactic antibiotics for opportunistic infections Consider bronchoscopy, lung biopsy If improves to Grade ≤ 1: Consider tapering steroids over at least 1 month If not improving after 48 hours or worsening: Consider adding additional immunosuppression (for example, infliximab, cyclophosphamide, IV immunoglobulin, or mycophenolate mofetil) Hepatic irAEs Grade of Liver Test Elevation (NCI -CTCAE v5) Initial Management Follow -up Management Grade 1 Grade 1 AST or ALT > ULN to 3.0 x ULN and/or Total bilirubin > ULN to 1.5 x ULN Consider continuing M7824 Consider continued liver function monitoring If worsens: Consider treating as Grade 2 or 3 to 4. Grade 2 AST or ALT > 3.0 to ≤ 5 x ULN and/or total bilirubin > 1.5 to ≤ 3 x ULN Consider withholding M7824 If returns to Grade ≤ 1: Consider resuming therapy. If elevation persists > 7 days or worsens: Consider treating as Grade 3 to 4. Grade 3 to 4 AST or ALT > 5 x ULN and/or total bilirubin > 3 x ULN Consider withholding or permanently discontinuing M7824 for Grade 3 events based upon if the clinical condition can be safely managed. For grade 4 events permanently discontinue treatment. If returns to Grade ≤ 1: Consider tapering steroids over at least 1 month If does not improve in > 7 days, worsens or rebounds: 46 Abbreviated Title: Combo Immunotx in HPV Cancers Version Date: 05.12.2023 Consider 1.0 to 2.0 mg/kg/day prednisone or equivalent Consider adding prophylactic antibiotics for opportunistic infections Consider consulting gastroenterologist/ hepatologist Consider obtaining MRI/CT scan of liver and liver biopsy if clinically warranted Consider adding mycophenolate mofetil 1 gram (g) twice daily If no response within an additional 7 days, consider other immunosuppressants per local guidelines. Renal irAEs Grade of Creatinine Increased (NCI -CTCAE v5) Initial Management Follow -up Management Grade 1 Creatinine increased > ULN to 1.5 x ULN Consider continuing M7824 Continue renal function monitoring If worsens: Consider treating as Grade 2 to 3 or 4. Grade 2 Creatinine increased > 1.5 and ≤ 6 x ULN Consider withholding M7824 Consider 1.0 to 2.0 mg/kg/day prednisone or equivalent. Consider adding prophylactic antibiotics for opportunistic infections Consider renal biopsy If returns to Grade ≤1: Consider tapering steroids over at least 1 month, and consider resuming therapy following steroids taper. If worsens: Treat as Grade 4. Grade 3 -4 Creatinine increased > 6 x ULN Consider withholding or permanently discontinuing M7824 for Grade 3 events based upon if the clinical condition can be safely managed. For grade 4 events permanently discontinue treatment. Consider 1.0 to 2.0 mg/kg/day prednisone or equivalent. Consider adding prophylactic antibiotics for opportunistic infections Consider renal biopsy Consider Nephrology consult If returns to Grade ≤1: Consider tapering steroids over at least 1 month. 47 Abbreviated Title: Combo Immunotx in HPV Cancers Version Date: 05.12.2023 Cardiac irAEs Myocarditis Initial Management Follow -up Management New onset of cardiac signs or symptoms and / or new laboratory cardiac biomarker elevations (e.g. troponin, CK -MB, BNP) or cardiac imaging abnormalities suggestive of myocarditis.