Neuro- Oncol 2008; 10(5):745- 751). Re-MATC H Protocol Page 56 of 106 Version: 20180628 Drug Name Route Dose Schedule Instructions for administration Carboplatin IV The lesser of 500mg/m2 or dosing = AUC 7 mg/ml- min per Calvert Formula; dilute to 4 mg/ml in Normal Saline Days -8, -7,-6 IV over 4 hours through central venous catheter Etoposide IV 250mg/m2; dilute to 0.3 mg/ml in Normal Saline Days -5,-4,-3 IV over 3 hours through central venous catheter Thiotepa IV 300mg/m2; dilute to 1 mg/ml in Normal Saline Days -5,-4,-3 IV over 3 hours through central venous catheter Peripheral Blood Stem Cells IV Minimum: 2x106 CD34+ cells/kg Day 0 IV through central venous catheter per institutional guidelines TTRNA -xALT IV 3x107/kg Day 1 IV over 10-30 minutes through central venous catheter . Pre-medicate 30 -60 minutes prior to infusion with acetaminophen (up to 10- 15 mg/kg/dose) and Benadryl ( up to 1 mg/kg) to reduce infusion- related reactions.