If opening of c apsules is necessary, it should be performed by hospital staff trained in handling chemotherapeutics. Chemotherapy precautions should be utilized in preparation. Gloves should be worn and all mixing media must be discarded as chemotherapy waste. TMZ is a vailable from commercial sources by the treating hospital pharmacy. Known AEs of Temozolomide Allergy/Immunology: sinusitis Blood/Bone Marrow: decreased WBC, lymphopenia, neutropenia, thrombocytopenia, anemia Cardiovascular: peripheral edema Constitutiona l Symptoms: fatigue, asthenia, fever, weight gain Dermatology/Skin: rash, pruritis Endocrine: adrenal hypercorticism Gastrointestinal: nausea, vomiting, constipation, diarrhea, anorexia Infection: viral infection, urinary tract infection Musculoskeletal/So ft Tissue: myalgia Neurology: convulsions, hemiparesis, dizziness, abnormal coordination, amnesia, insomnia, paresthesia, somnolence, paresis, ataxia, dysphasia, abnormal gait, confusion, anxiety, depression Ocular/Visual: diplopia, blurred vision, visual deficit or changes Pain: headache, back pain, abdominal pain, breast pain (female) Pulmonary/Upper Respiratory: upper respiratory tract infection, pharyngitis, coughing Renal/Genitourinary: urinary incontinence, micturition increased frequency Re-MATC H Protocol Page 73 of 106 Version: 20180628 18.6 Carboplatin Source and Pharmacology The mechanism of action of carboplatin (Paraplatin®) NSC #241240 (092006) would appear to be similar to that of cisplatin. It binds to replicating DNA causing single strand breaks and interstrand cross -links with DNA.