1 1.1 BACKGROUND ...................................................................................................................................... 1 1.1.1 Current Therapies for Malignant Mesothelioma ...................................................................... 1 1.1.2 Mesothelin ............................................................................................................................... 1 1.1.3 Listeria monocytogenes (Lm)-Based Vaccine Therapy ........................................................... 2 1.2 RATIONALE FOR COMBINATION OF CRS -207 AND CHEMOTHERAPY .................................... 5 1.3 RATIONALE FOR USE OF LOW -DOSE CYCLOPHOSPHAMIDE AND CRS -207 .......................... 7 2.0 OBJECTIVES ........................................................................................................................................