REGISTRATION PROCEDU RES 4.1 General Guidelines for DF/HCC and DF/PCC Institutions Institutions will register eligible participants with the DF/HCC Quality Assurance Office for Clinical Trials (QACT) central registration system. Registrations must occur prior to the initiation of any imaging . Any participant not registered to the protocol before protocol therapy begins will be considered ineligible and registration will be denied. An investigator will confirm eligibility criteria and a member of the study team will complete the QACT protocol- specific eligibility checklist. Following registration, participants may begin protocol therapy . Issues that would cause treatment delays should be discussed with the Overall Principal Investigator (PI). If a participant does not receive protocol therapy following registration, the pa rticipant’s registration on the study must be canceled . Notify the QACT Registrar of registration cancellations as soon as possible. 4.2 Registration Process for DF/HCC and DF/PCC Institutions The QACT registration staff is accessible on Monday through Friday, from 8:00 AM to 5:00 PM Eastern Standard Time. In emergency situations when a participant must begin protocol therapy during off-hours or holidays, call the QACT registration line at and follow the instructions for registering participants after hours. The registra tion procedures are as follows: • Obtain written informed consent from the participant prior to the performance of any protocol specific procedures or assessments. • Complete the QACT protocol- specific eligibility checklist using the eligibility assessment documented in the participant’s medical record and/or research chart. To be eligible for registration to the protocol , the participant must meet all inclusion and exclusion criterion as described in the protocol and reflected on the eligibility checklist. Reminder : Confirm eligibility for ancillary studies at the same time as eligibility for a treatment protocol. Registration to both treatment and ancillary protocols will not be completed if eligibility requirements are not met for all studies. • Fax the eligibility checklist(s) and all pages of the consent form(s) to the QACT at Protocol A pilot study to evaluate PBR PET as an indicator of inflammation in brain tumor patients treated with chemoradiation or immunotherapy. Version Date: June 20, 2018 13 .