9.4 Safety Planned time points for all safety assessments are listed in the Schedule of Activities ( Section 2 ). 9.4.1 Physical ExaminationsRefer to the Schedule of Activities for the timing of assessments (Section 2). 9.4.2 Vital Signs Refer to the Schedule of Activities for the timing of assessments (Section 2). 9.4.3 Electrocardiograms Refer to the Schedule of Activities for the timing of assessments (Section 2). For the purposes of monitoring participant safety, the investigators will review the 12lead ECGs using their site’s standard ECG machines throughout th e study. 9.4.4 Clinical Safety Laboratory Assessments •Investigators must document their review of each laboratory safety re port. •A central/local laboratory w ill perform the analyses and w ill provide reference ranges for these tests. •Results of clinical laboratory tests performed on Day -1 must be available prior to dosing. •The clinical tests that will be performed are shown in Table 9.4.4-1 . •Results of all laboratory tests required by this protocol must be provided to the Sponsor, recorded either on the laboratory pages of th e CRF or by another mechanism as agreed upon between the investigator and BMS (eg, provided electronically). If the units of a test result differ from those printed on the CRF, the recorded laboratory values must specify the correct Revised Protocol No.: 04 Date: 31-May-2019 107 Approved 5.0 v Approved 1.0 v Clinical Protocol CA021002 BMS-986226 anti-ICOS units. Any abnormal laboratory test result cons idered clinically significant by the investigator must be recorded on the appropriate AE page of the CRF (see Section 9.2.6 ). Table 9.4.4-1: Clinical Laboratory Tests Hematology Prothrombin time, activated partial thromboplastin time, and international normalized ratio (at screening only) Platelet count Hemoglobin Hematocrit Total leukocyte count, including differential Serum Chemistry Aspartate aminotransferase Alanine aminotransferase Total bilirubin Direct bilirubin (reflex only) Alkaline phosphatase Lactate dehydrogenase CreatinineBlood urea nitrogen Glucose (Fasting required at screening only) Gamma glutamyl transferase (reflex only) Lipase Testosterone (PRC only) C-reactive proteinTotal proteinAlbumin Sodium Potassium ChlorideCarbon Dioxide Calcium Phosphorus Magnesium Creatine kinase Creatinine clearance- screening onlyThyroid stimulating hormone Free T3 and T4 (screening and reflex only) Amylase Urinalysis Protein Blood Glucose Leukocyte esterase Specific gravity pH Microscopic examination of the sediment if positive for blood, protein, or leukocy tes esterase on dipstick Serology Serum for hepatitis C antibody (If hepatitis C antibody is positive reflex to hepatitis C RNA) or hepatitis C RNA, hepatitis B surface antigen. Testing for HIV-1 and HIV-2 must be performed at sites only where mandated by local requirements.