2. 2, a me n de d t he misse d visits t o acc o u nt f or t he c ha n ge t o 1 6 wee kl y efficac y assess me nt bei n g o pti o nal a n d clarifie d a R E CI S T visit res p o nse of N E d oes n ot c o u nt as a misse d visit. Secti o n 3.