Coding: Alpha numerical code was used c. Monitoring: Data was entered after every day of work and supervised by guide. d. Statistical analys is: will be conducted as per both per -protocol and intention - to treat population (defined as all enrolled patients to whom study drug will be given; with the last observation carried forward) basis using two sided tests. For descriptive statistics , percent age, mean, S.D., m edian, and minimum, maximum will be calculate d along with graphical and tabular presentation. For inferential statistics , statistical methods that will be used are as follow 1. Chi square test and Fisher’s exact test to compare the categoric al data between the groups. 2. Paired t test for comparing normally distributed continuous variables (pretreatment and post treatment DLQI) at different time point within the groups. 3. Mann - Whitney U test to compare the not normally distributed variables (age, duration of illness, size, number) 4. Kaplan –Meier curves to compare the response rate (complete, excellent, good or poor response) on each follow up visit (week 3, 6, 9, 12) between the groups. Test of significance will be considered when value of p ≤ 0.05 . (l) Ethical clearance : Will be obtained from the Institutional Review Committee (IRC) , BPKIHS and Nepal Health Research Council (NHRC) (m) Permission to use copyright questionnaire/Pro forma : N/A 11. For Intervention trial a. Permission from Dr ug Con troller of Nepal: not required b. Safety measure :will be applied c. Plan to withdraw :As per the decision of treating p hysician 12. Maintain the confidentiality of subject : Yes 13. References : attached 14. Whether available resources are adequate: adequate 15. Other resources needed : not needed 16. Cost involved (Approx in NRS) a. Investigations :60,000 (approximate) b. Surgery :NA c. Drugs :64,500 (approximate) Group A - MMR cost × number of participants × number of sessions per patient =350×30×5 =52,500 Group B - Vitamin D cost × number of participants × number of sessions per patient =80×30×5 =12,000 Total cost = 64,500 Both MMR and Vitamin D are easily available in local pharmacy. 17.