i. The serum chemistry assessments will include sodium, potassium, chloride, carbon dioxide, blood urea nitrogen, creatinine, ca lcium, total protein, albumin, glucose, total bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. These samples will be collected for processing by the central laboratory. Samples must by collected before study treatment administration. Calculat ed Creatinine Clearance (CrCl) must be assessed during the screening period to determine eligibility. See the laboratory manual for more in formation.