Herceptin infusions should not be administered or mixed with Dextrose solutions. d. Storage Vials of Herceptin are stable at 2°C–8°C (36°F–46°F) prior to reconstitution. Do not use beyond the expiration date stamped on the vial. A vial of Herceptin reconstituted with BWFI, as supplied, is stable for 28 days after reconstitution when stored refrigerated at 2°C–8°C (36°F–46°F), and the solution is preserved for multiple use. Discard any remaining multi-dose reconstituted solution after 28 days. If unpreserved SWFI (not supplied) is used, the reconstituted Herceptin solution should be used immediately and any unused portion must be discarded. DO NOT FREEZE HERCEPTIN THAT HAS BEEN RECONSTITUTED. The solution of Herceptin for infusion diluted in polyvinylchloride or polyethylene bags containing 0.9% sodium chloride for injection, USP, may be stored at 2°C–8°C CONFIDENTIAL Page 27 of 102 Protocol: HERCEPTIN® + E75/GM-CSF Version 3.1 ML25749 05 March 2017 (36°F–46°F) for up to 24 hours prior to use. Diluted Herceptin has been shown to be stable for up to 24 hours at room temperature 15°C–25°C; however, since diluted Herceptin contains no effective preservative the reconstituted and diluted solution should be stored refrigerated (2°C–8°C). 4.3.3 Herceptin Dosage Modification Dose modification of Herceptin is not permitted.