Figure 20. 38 Abbreviated Title: Combo Immunotx in HPV Cancers Version Date: 05.12.2023 3.1.1 Dose Limiting Toxicity DLT for first 6 participants : Dose -limiting toxicity (DLT) will be defined as any one of the following adverse events, possibly attributable to study drugs, that occur within 28 days of the start of therapy: • Any Grade 4 or higher adverse drug reactions (ADRs) as defined by CTCAE v5.0 and assessed as possibly related to that agent by the Investigator, except for laboratory values that are asymptomatic or resolve to Grade ≤ 1 or baseline grade within 7 days without medical intervention . • Any Grade 3 ADRs possibly attributed to an agent except for any of the following: o Grade 3 flu -like symptoms or fever, as well as associated symptoms of fatigue, headaches, nausea, emesis which can be controlled with conservative medical management.