: 1997) 33, 211 -218 (2010). 58. Y. Ge et al. , Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome. Cancer immunology, immunotherapy : CII 61, 353 - 362 (2012). 59. V. Cerullo et al. , Immunological effects of low -dose cyclophosphamide in cancer patients treated with oncolytic adenovirus. Molecular therapy : the journal of the American Societ y of Gene Therapy 19, 1737 -1746 (2011). 60. D. T. Le, E. M. Jaffee, Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Cancer research 72, 3439 -3444 (2012). 61. T. Kalantari et al. , Generation of immunogenic a nd tolerogenic clinical-grade dendritic cells. Immunologic research 51, 153 -160 (2011). 62. R. M.