Bayesian approach may be used to evaluate the efficacy data. For example, Bayesian approach with a non- informative Jeffery’s prior beta (0.5,0.5) will be used to calculate the posterior probability the ORR of the study treatment exceeds various ORR thresholds of interest in the end of the study. For Cohort 5B (AdC68 + pDNA + treme 80 mg SC + PF -0689159 130 mg SC.