A research nurse and/or study coordinator will approach these patients about being in the trial and will introduce the trial to the prospective patient. If the patient is interested and appears eligible, the nurse will arrange to counsel the patient. The nurse will thoroughly screen the patient for inclusion and exclusion eligibility criteria. If the patient remains interested and eligible, informed consent will be obtained. Written informed consent will be obtained from all study participants. Prospective participants will be provided with a copy of the consent form to read. The Principal Investigator (PI) or individuals who are authorized by their institution to obtain informed consent and who are familiar with the study, will explain the study and review the consent form with the patient. Patients will be given ample time to ask and have all questions answered prior to signing the consent form.