SM.TEMP.013 version 5 CRUKD/17/003 RAP Version: 2.0 09Mar2023 FINAL 1 CANCER RESEARCH UK Reporting Analysis Plan Protocol Number: CRUKD/17/003 Protocol Name: AST-VAC2 EudraCT Number: 2016- 002577- 35 RAP Fin al Version: 2.0 Date: 09Mar2023 Replaces Version: N/A Date: N/A Name: Date: Title: Clinical Study Manager (Sponsor) Signature: Name: Date: Title: Medical Advisor (Sponsor) Signature: Name: Date: Title: Chief Investigator Signature: SM.TEMP.013 version 5 CRUKD/17/003 RAP Version: 2.0 09Mar2023 FINAL 2 SUMMARY OF CHANGES TO PREVIOUS REPORTING ANALYSIS PLAN VERSION This summary of changes is intended to highlight the important revisions that were made during the most recent update to the reporting analysis plan (RAP) to generate the current version. This document has been written based on information contained in the study protocol and data management plan detailed in the table below. Protocol version DMP version RAP version Revised section of RAP Summary of changes Date updated 5.0 2.0 1.0 5.9, 6.1 & 6.2 Section 5.9 – note added about patients with data censored for survival, referen ce to CEA listing added, Table 14 updated to refer to ‘Date of Death or Last Contact’. Section 6.1 – CEA listing added Section 6.2 – RAP tables 4, 5 & 6 numbering for CSR revised 12Dec2022 Final review prior to database lock Protocol version DMP version RAP version Revised section of RAP Summary of changes Date updated Protocol amendments may be applicable during the study. The RAP will be reviewed against the amendments and updated where necessary. The summary of changes table above should record all changes to the RAP in light of protocol amendments however if no changes were required, this should be recorded also. CONTRIBUTORS Medical Writer: Clinical Data Manager: Clinical Data base Programmer: Translational Scientist: Biomarker Development Scientist: SM.TEMP.013 version 5 CRUKD/17/003 RAP Version: 2.0 09Mar2023 FINAL 4 Table of Contents Summary of changes to previous Reporting Analysis Plan version ........................................................................... 2 LIST of abbreviations and definition of terms .........................................................................................................