12, 3770 (2021). Acknowledgements We extend our gratitude to patients and their families for partaking in this clinical trial and for their donations of tissue for research. We acknowledge the contributions of all the clinical research staff of the Hepatopancreatobiliary Service, the Precision Pathology Biobanking Center, and the Center for Molecular Oncology at MSK. This work was supported by a Stand Up to Cancer Convergence Award (to B.D.G. and V.P.B.), the Lustgarten Foundation (to B.D.G., and V.P.B.), the NIH U01 CA224175 Pancreatic Cancer Microenvironment Network Cancer Moonshot Award (to V.P.B.), the Damon Runyon Clinical Investigator Award (to V.P.B.), the Ben and Rose Cole Charitable PRIA Foundation (to V.P.B), the Mark Foundation ASPIRE Award (to B.D.G.) and the Pershing Square Sohn Prize-Mark Foundation Fellowship (to B.D.G.). M.Ł. is a Pew Biomedical Scholar. Services of the Integrated Genomics Core were funded by the NCI Cancer Center Support Grant (CCSG, P30 CA08748), Cycle for Survival, and the Marie-Josée and Henry R. Kravis Center for Molecular Oncology. The team at MSK sponsored the clinical trial. The imCORE Network, Genentech, BioNTech, Stand Up To Cancer, the Lustgarten Foundation, and the National Cancer Institute Pancreatic Cancer Microenvironment Network funded the clinical trial and the biomarker studies. Author contributions V.P.B., J.D.W., T.M., Ö.T., I.M. and U.S. conceived the clinical trial concept. N.Cohen, E.O.R. and V.P.B. designed the clinical trial. V.P.B. and E.O.R. oversaw all aspects of clinical trial conduct as primary and co-primary investigators, respectively. A.S.E., P.M., W.P., R.S., A.M.V., E.W., A. Desai, E.O.R., K.C.S., A.C.W., M.I.D., T.P.K., W.R.J., J.D. and V.P.B. enrolled patients to the clinical trial. K.C.S., A.C.W., M.I.D., T.P.K., W.R.J., J.D. and V.P.B. performed the surgeries. A.S.E., P.M., W.P., R.S., A.M.V., E.W., A. Desai, E.O.R. and V.P.B. administered the experimental medicines and evaluated toxicity. C.O. and N.P. led the MSK clinical trial research study team. S.K. and R.K.D performed the radiography assessments. O.B. and L.T. performed all the pathology assessments. L.A.R. performed the immunological assays with assistance from A. Dobrin, R.Y., A.K.C., T.W., J.R., M.A., P.G., A.Z., Z.O. and G.P.