..25 10. APPENDICES ................................................................................................................. ..26 10.1. Appendix: Statistical Methods for Immunogenicity (serology)............................2610.2. Appendix: PSA kinetics_AppendiCES .................................................................2810.3. Appendix: Time to Event Data Analysis Censoring Rules ...................................2910.4. Appendix: Immune-related Response Criteria per RECIST 1.1 (irRECIST) .......30 LIST OF TABLES Table 1. Probability of Escalating Dose ...............................................................................8Table 2. Outcome and Event Dates for irPFS and irDR Analyses .....................................32 LIST OF FIGURES Figure 1. Overall Study Design..............................................................................................5CCI CCI Protocol B7791001 Statistical Analysis Plan PFIZER CONFIDENTIAL Page 41. AMENDMENTS FROM PREVIOUS VERSION(S) Amendment 2 Section 2.1 S tudy design texts are updated to be consistent with the prot ocol amendment .