0. Se pte m ber 1 9 , 2 0 1 8 Pa ge | 4 5 7. 1. 5 T u m or Tiss ue C ollecti o n a n d C orrel ati ve St u dies Bl o o d S a m pli n g We will e val uate p 5 3 -s p ecific I R a n d M D S C le v els as well as ot her i m m u ne cells i n patie nts d uri n g treat me nt . T hese para meters will be c orrelate d wit h cli nical o utc o mes. Peri p heral bl o o d will be c ollecte d pri or t o t he treat me nt a n d at differ e nt ti me p oi nts (see cale n d ar secti o n 6. 0) d uri n g a n d after t he tr eat me nt. M o n o n uclear cells will be is olate d a n d k e pt fr oze n i n ali q u ots i n li q ui d nitr o ge n. All sa m ples fr o m o ne p atie nt will be teste d si m ulta ne o usl y t o a v oi d t he i m pact of i nter- e x peri me ntal variati o n. 7.