Med. 28, 1599–1611 (2022). 31. Neely, J. et al. Abstract 2145. Genomic and transcriptomic analyses related to the clinical efficacy of first-line nivolumab in advanced hepatocellular carcinoma from the phase 3 CheckMate 459 trial. Cancer Res. 82, 2145 (2022). 32. Robert, L. et al. Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes. Oncoimmunology 3, e29244 (2014). 33. Gangaev, A. et al. Differential effects of PD-1 and CTLA-4 blockade on the melanoma-reactive CD8 T cell response. Proc. Natl Acad. Sci. USA 118, e2102849118 (2021). 34. Szabo, P. A.