Comorbidities or Prior Conditions: a. Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. b. Prior organ transplantation including allogenic stem -cell transplantation. c. Known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or in situ cervical cancer that has undergone potentially curative t h e r apy . d. Known history of active TB (Tuberculosis). e. Known history of HIV or known acquired immunodeficiency syndrome. f. Active Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infection at screening or positive serologies indicating prior infection. g.