5-FU: most fre quent toxicities reported with 5 -FU were stomatitis, oesopharyngitis, diarrhoea, anorexia, nausea and emesis, alopecia, dermatitis and leucopenia. Leucovorin : most frequent toxicities reported with Leucovorin were diarrhoea, stomatitis, myelosupression, skin rash, hives, pruritus and wheezing (although rare). 8.