Section 7.3.6 Management of Drug- related Infusion ReactionsUpdated data on drug-related infusion reactions. Updated to provide most recent data/information on drug-related infusion reactions. Revised Protocol No.: 04 Date: 31-May-2019 4 Approved 5.0 v Approved 1.0 v Clinical Protocol CA021002 BMS-986226 anti-ICOS SUMMARY OF KEY CHANGES FOR REVISED PROTOCOL 04 Section Number & Title Description of Change Brief Rationale Appendix 02 Study Governance ConsiderationsUpdated potential serious breach language and included additional language updates per BMS protocol standards.Updated per BMS protocol standards. Revised Protocol No.: 04 Date: 31-May-2019 5 Approved 5.0 v Approved 1.0 v TABLE OF CONTENTS TITLE PAGE ................................................................................................................ DOCUMENT HISTORY .............................................................................................. OVERALL RATIONALE FOR REVISED PROTOCOL 04: ..................................... SUMMARY OF KEY CHANGES FOR REVISED PROTOCOL 04 ......................... TABLE OF CONTENTS ..............................................................................................