Women who are pregnant or breast feeding. 5.3 Inclusion of Women, Mi norities and Children Both men and women an d members of all races and ethnic groups are eligible for this study. Child ren are not eligible for this study because the safety and tolerability of the proposed dosing schedule has not been determined in adults. Heat Biologics Protocol No. HS130 -001 A Phase I Study of HS -130 in combination with HS-110 in patients with solid tumors HS130- 001 29 of 60 Version 2.0 - 11 Feb 2020 Confidential - Entire Page 5.4 Withdrawal Criteria Protocol therapy will be discontinued at any time if any of the following situations occur: 1. Prog ressive disease (not including unconfirmed radiographic PD if Investigator opts to continue treatment as outlined in Section 8.2 ).