h: Pregnancy test; for women of childbearing potential, a negative pregnancy test (urine or serum) must be documented. i: Approximately 23 mL blood per draw Day 1 (pre -dose) and Day 8 for C1 and C2, and at 30 -day safety follow -up visit for immune res ponse labs (See Section 8.6 ). j: Cytokines and chemokines sample collection on Day 1 for C1 and C2 at time -points: Before HS130/HS110 treatment, a nd 2 hr ± 10 minutes after treatment. For C3 and beyond only if the patient is symptomatic i.e.