Specimens will be labeled with the subjects research participant number. 9.1 Blood Collection ALL SUBJECTS 100ml total whole blood (90mL collected in sodium heparin vacutainer tubes and 10mL collected in no-anticoagulant vacutaine tubes- from Becton Dickinson) collected at each ti me point specified in the study calendar (pre-study, and during weeks 4, 12, 24, 36, 48, and 60) will be sent to: Send the sample(s) priority overnight via FedEx Next Day to: Dendreon Corporation Attention: Clinical Immunology 1208 Eastlake Avenue E, Seattle, WA 98102 Phone: 206-829-1639 ONL Y SUBJECTS RECEIVING RADIATION AT CITY OF HOPE 10ml of the whole blood in the BD Vacutainer CPT tube (with Heparin) will collected at baseline (week 0) and at week 4 after radiation to be sent to the laboratory of Dr. Marcin Kortylewski within 4 hours of collection to avoid degradation of the phosphomoieties (i.e., pSTAT3) assessed in this protocol.