21- 6. CONFIDENTIAL CRUKD/17/003 Protocol Final 5.0 dated 08Jun2021 Page 65 of 72 EudraCT number: 2016 -002577 -35 Cancer Research UK 9. Eskelinen, E.L., Roles of LAMP- 1 and LAMP -2 in lys osome biogenesis and autophagy. Mol Aspects Med, 2006.