Protocol Deviations / Violations Protocol deviations will be identified and classified as major (violations) before the database is locked. Major protocol deviations may include but are not limited to: • Received the wrong study medication • Dose not properly administered, including o Administrations in which Cy was not administered within 24 hour s of CRS- 207 o Administrations in which protocol required pre- medications were not given • Did not complete at least 2 chemotherapy cycles • Received prohibited concomitant medications • Violation of inclusion or exc lusion criteria , including o Misdiagnosis Aduro Biotech, Inc. CONFIDENTIAL Protocol ADU -CL-02 Final Version 1 Page 13 of 24 04MAY2018 5.