15. Coagulation : Should include Prothrombin Time (PT) or International Normalized Ratio (INR) and Partial Th romboplastin Time (PTT). Samples will be analyzed locally. 16. Cardiac Troponin : For participants undergoing screening, circulating levels of cardiac Troponin - I (cTnI) must be measured and found to be within the normal reference range within 28 days before study entry, preferably using the central laboratory kits provided. See Section 7.1.8 for full details.