59. Lu YC, Yao X, Crystal JS et al. Efﬁcient identiﬁcation of mutated cancer antigens recognized by T cells associated with durable tumor regressions. Clin Cancer Res 2014; 20(13): 3401–3410. 60. Tran E, Turcotte S, Gros A et al. Cancer immunotherapy based on mutation-speciﬁc CD4 þT cells in a patient with epithelial cancer. Science 2014; 344(6184): 641–645.