Ciuleanu T, St elmakh L, Cicenas S, Miliauskas S, Grigorescu AC, Hillenbach C, et al. Efficacy and safety of erlotinib versus chemotherapy in second -line treatment of patients with advanced, non -small -cell lung cancer with poor prognosis (TITAN): a randomised multicentre , open -label, phase 3 study. Lancet Oncol. 2012;13(3):300 ‑8. doi: 10.1016/S1470 - 2045(11)70385 -0. 16.