Data handling: Data will be entered in Microsoft Excel 2010 (Microsoft Corporation, Redmond, Washington, USA) and statistical analysis will be done using Statistical Package for the Social Sciences 10.5 version (Chicago, Inc) 2. Coding: Alpha nu merical code will be used 3. Monitoring: Data will be entered after every day of work and supervised by guide. 4. Statistical analysis will be conducted as per both per -protocol and intention -to treat population (defined as all enrolled patients to whom study drug will be given; with the last observation carried forward) basis using two sided tests. For descriptive statistics , percentage, mean, S.D., m edian, and minimum, maximum will be calculate d along with graphical and tabular presentation. For inferential sta tistics , statistical methods that will be used are as follow a. Chi square test and Fisher’s exact test to compare the categorical data between the groups. b. Paired t test for comparing normally distributed continuous variables (pretreatment and post treatment DLQI) at different time point within the groups. c. Mann - Whitney U test to compare the not normally distributed variables (age, duration of illness, size, number) d. Kaplan –Meier curves to compare the response rate (complete, excellent, good or poor response) o n each follow up visit (week 3, 6, 9, 12) between the groups. 27 Test of significance will be considered when value of p ≤ 0.05. REFERENCES 1.