Page 36 of 50 IRB Protocol No. 12367 Version Date: 10/24/2017 Version: 09 e. Symptomatic deterioration : Global deterioration of health status requiring discontinuation of treatment without objective evidence of progression. Efforts should be made to obtain objective evidence of progression after discontinuation. f. Assessment inadequate, objective status unknown : Progression or symptomatic deterioration has not been documented, and one or more target measurable lesions have not been assessed or inconsistent assessment methods were used. g.