Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). European journal of cancer (Oxford, England : 1990) 2009;45. 24. Seymour L, Bogaerts J, Perr one A, et al. iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics. The Lancet Oncology;18:e143 -e52. 25. Johnson DB, Balko JM, Compton ML, et al. Fulminant Myocarditis with Combination Immune Checkpoint Blockade. The New E ngland journal of medicine 2016;375:1749 -55. Heat Biologics, Inc. Viagenpumatucel -L Protocol HS110 -102 CONFIDENTIAL Amendment 6, 24 May 2019 Page 82 of 95 APPENDIX 1: ECOG PER FORMANCE STATUS SCAL E Grade ECOG 0 Fully active, able to carry on all pre -disease performance without restriction . 1 Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g. , light house work, office work . 2 Ambulatory and capable of all self -care but unable to carry out any work activities. Up and about more than 50% of waking hours . 3 Capable of onl y limited self -care, confined to bed or chair more than 50% of waking hours . 4 Completely disabled. Cannot carry on any self -care. Totally confined to bed or chair . 5 Dead .