2009;45(2):228-47. Abbreviated Title: mRNA-Based, Cancer Vaccine Version Date: January 23, 2019 5813 APPENDICES APPENDIX A: M ETHODS FOR SELECTING DEFINED EPITOPES ,PREDICTED EPITOPES ,AND TUMOR SUPPRESSOR AND DRIVER NEOANTIGENS Three different classes of immunogenic antigens will be included in the vaccine backbone: 1. Defined epitopes 2.