Document type: Study Protocol Official Title: A Phase I/II Trial of TG01 and Gemcitabine as Adjuvant Therapy for Treating Patients with Resected Adenocarcinoma of the Pancreas NCT Number: NCT02261714 Document date: 27/06/18 Confidential 1 / 87 CLINICAL TRIAL PROTOCOL Trial Protocol No. CT TG01 -01 Title A Phase I/II Trial of TG01 and Gemcitabine as Adjuvant Therapy for Treating Patients with Resected Adenocarcinoma of the Pancreas EUDRACT/IND # 2012- 002400- 40 Trial Phase Phase I /II trial Trial Physician Date 27 June 2018 Version Final version 10.0 CT TG01 -01 Version v10.0 27 June 2018 Confidential 2 / 87 TABLE OF CONTENTS SPONSOR SIGNATURE PAGE .................................................................................................. 7 1.