5 2.4 Positive T-cell Responders ......................................................................................................... 5 Syne qua non study no: TAX12001 Targovax study no: CT TG01 -01 Page 3 of 5 Date: 04OCT2018 Version: Final 1.0 ST/form/038/1 LIST OF ABBREVIATIONS ATP All Treated Patients DFS Disease -free Survival OS Overall Survival SAP Statistical Analysis Plan Syne qua non study no: TAX12001 Targovax study no: CT TG01 -01 Page 4 of 5 Date: 04OCT2018 Version: Final 1.0 ST/form/038/1 1 INTRODUCTION This is an addendum to the final statistical analysis plan (SAP) dated 02 MAY 2018 documenting additional analyses following database lock. Full details of the changes are detailed below.