weight and EC OG P er f Status)bX X X X X X X X X X X 12-Lead ECGaX X X X X Vital Signs (T, HR, BP , RR)eX X X X X X X X X X X Concomitant Medication(s)/ Procedure(s) X X X X X X X X X X X X X Adverse Events (starting or worsening after IC)f X X X X X X X X X X X X X Blood Hematology (complete blood count, differ ential, platelets)aX X X X X X X X X X X X X Chemistry (glucose, BUN, creat., Na, K, Cl, CO 2, Ca, Mg, protein, albumin, Tbili., AST, ALT, ALP, LDH)aX X X X X X X X X X X C hemistry cont. (Free T3, Free T4, TSH)aX X X X X X X X X X X C hemistr y cont. (Amy lase and lipase)aX X X X X X X X X X X Ur inaly sisa,cX X X X X X X C oagulation par ameter sa,dX Serum pregnancy test (Urine test only on Day 1)a Up to 1 week before Tx s ta rt X X X Specimens for Other Peripheral Blood Assays Blood for exosomal profiling aX X Blood for PaxGene RNA and DNAa,k Note: Discontinued per Amendment 9.1 X XJXJ Blood (P BM C and plasma) for flow cy tometr y and biological assay sa,i,k Note: Discontinued per Amendment 9.1 X XJXJ Blood for humoral responses and other bi oma rkersa,k Note: Discontinued per Amendment 9.1 X XJXJ Biopsy or FFPE slides for tumor microenvironmentgX Ov er all Sur v iv al Progres s i on Free Survi va lSpecimens for Routine Laboratory Procedures5 Study Week 1 11 X (one week after 3rd or 5th BI 1361849 injection) Cycle 4 14J Tumor and Disease Assessments21 17 13Treatment (each cycle = 4 weeks) Long Term Follow-upTumor BiopsyLUD2014-012-VAC Study FlowchartScreening / Baseline Cycle 2 Cycle 3 2 3 7Cycle 1 6J 9 Sponsor: Ludwig Institute for Cancer Research. Protocol Number: LUD2014- 012-VAC. CONFIDENTIAL SAP Version: 3.0 Effective Date: 09DEC2020 Page 25 of 27 Cycle 8 Cycle 9Cycle 11 Cycle Day 1 (±3) 15 (±3) 22(±2) 1 (±3) 1 (±3) 1 (±3) 15 (±3) 1 (±3) 1 ( ±3) 8 (±2) Cumulative Study Day 169 183 190 197 225 253 267 281 309 316 Treatment Durvalumab (Arms A and B) X X X X X X Tremelimumab (Arm B) BI 1361849 - 6 components (Arms A and B) X X X X Disease Staging (date/stage at 1st diagnosis and at study entry) Disease Assessment by ir REC IST/REC ISTa X X X Study Procedures and Examinations Eligibility Assessment and Informed Consent (IC)h Demogr aphics (incl. DoB; sex ; height; r ace; ethnicity) M edical histor y P hy sical Ex am (incl.