Heat Biologics Protocol No. HS130 -001 A Phase I Study of HS -130 in combination with HS-110 in patients with solid tumors HS130- 001 10 of 60 Version 2.0 - 11 Feb 2020 Confidential - Entire Page 15. Substance abuse, medical, psychological or social conditions that may interfere with the patient’s participation in the trial or evaluation of the trial result in the opinion of the Investigator.