If there is no available tumor sample or pathology report, a biopsy will be performed to confirm the diagnosis. 34 Abbreviated Title: Combo Immunotx in HPV Cancers Version Date: 05.12.2023 2.3 PARTICIPANT REGISTRATION AND STATUS UPDATE PROCEDURES Registration and status updates (e.g., w hen a participant is taken off protocol therapy and when a participant is taken off -study) will take place per CCR SOP ADCR -2, CCR Participant Registration & Status Updates found at: https://ccrod.cancer.gov/confluence/pages/viewpage.action?pageId=73203825 . 2.3.1 Screen Failure Screen failures are defined as participants who consent to participate in the clinical trial but are not subsequently assigned to the study intervention or entered in the study.