112. Topalian, S.L., et al., Safety, activity and immune correlates of anti-PD1 antibody in cancer. N Engl J Med, 2012. 366(26): p.2443-54. Pro00065241: AVERT Version: 20170 315 Duke Cancer Institute CONFIDENTIAL Page 60 18 APPENDICES 18.1 Nivolumab Investigator Brochure (s) Please see separate upload in eIRB. Pro00065241: AVERT Version: 20170 315 Duke Cancer Institute CONFIDENTIAL Page 61 18.2 I-O Safety Algorithms Please see separate upload in eIRB. Pro00065241: AVERT Version: 20170 315 Duke Cancer Institute CONFIDENTIAL Page 62 18.3 PRTBTC Imaging SOP Please see separate upload in eIRB. Pro00065241: AVERT Version: 20170 315 Duke Cancer Institute CONFIDENTIAL Page 63 18.4 CTRAF Please see separate upload in eIRB. Pro00065241: AVERT Version: 20170 315 Duke Cancer Institute CONFIDENTIAL Page 64 18.5 MMSE Please see separate upload in eIRB. Pro00065241: AVERT Version: 20170 315 Duke Cancer Institute CONFIDENTIAL Page 65 18.6 PRTBTC DSMBplus Charter Please see separate upload in eI RB.