Has any other serious illnesses or medical conditions such as, but not limited to: CT TG01 -01 Version v 10.0 27 June 2018 Confidential 49 / 87 • Any uncontrolled infection • Uncontrolled cardiac failure classification III or IV (NY Heart Association) • Uncontrolled systemic and gastro- intestinal inflammatory conditions • Bone marrow dysplasia • History of auto- immune disease • History of adverse reactions to vaccines 5. Known history of positive tests for HIV/AIDS, hepatitis B or C 6. Pregnant or lactating females or have no pregnancy test at baseline (postmenopausal women must have been amenorrhoeic for at least 12 months to be considered of non-childbearing potential). 7. Contraindication to gemcitabine treatment 8. Have had any other malignancies within last 3 years (except for adequately treated carcinoma of the cervix or basal or squamous cell skin cancer) 9. Known malignant brain lesion(s) 10. Are unlikely to start chemotherapy within 12 weeks of surgery (e.g. delayed wound healing, or infection, etc.) 11.