POOLING OF CENTRES Results from all study centers will be combined for all safety and efficacy analyses. DocuSign Envelope ID: B3F56764-C440-4885-BA44-7578C4A73DB3 Stemline Therapeutics, Inc. Protocol: STML- 701-0114 Version 3.0, 10-JUL-2015 (Amendment 2) Statistical Analysis Plan Page 26 of 63 6.6. SUBGROUPS Parameter Description MGMT promoter methylation status (MGMT: O6- methylguanine-DNA methyltransferase) Methylayed/hypermethylated Unmethylated Unknown/not available IDH1 mutation status (IDH1: isocitrate dehydrogenase) Mutated Not-mutated Unknown/not available 6.7. SAP VERSION CONTROL Draft versions of the SAP will be numbered sequentially as Version 0.i.