f A spiral CT scan of the thorax and abdomen will be performed. If a subject cannot have a CT scan (eg, due to an allergy to contrast dye), an MRI should be performed. CT scans may be done within 1 week prior to or after scheduled visit, and must also be done prior to initiation of chemotherapy up to the start of chemotherapy. Optional FDG -PET may be done. A clinical assessment of tumor status using modified RECIST will be completed. g Complete physical examinations will be conducted at baseline and EOC; symptom -directed physical examinations to be conducted on Day 1 of dosing weeks. h Blood pressure, pulse, respiratory rate, temperature and pulse oximetry are required as indicated. Weight will be recorded on Day 1 of dosing weeks. Height is required at screening only. Pre- dose blood pressure should be measured in a supine position after the subject has been resting for at least 5 minutes. i Pregnancy tests will be administered to women of childbearing potential: serum pregnancy test is required at screening, and pregnancy tests (urine or serum) are required before doses on Day 1 of CRS- 207 dosing weeks. j Creatinine clearance is to be calculated by Cockcroft -Gault formula = {[(140 -age) x weight in kilograms] x [0.85 if female]}/[72 x creatinine in mg/dL] k Clinical hematology: CBC with differential ANC, platelet count; serum chemistry: sodium, potassium, chloride, bicarbonate, glucose, BUN, creatinine, LDH, ALT, AST, alkaline phosphatase, bilirubin (total, direct, and indirect), total protein, albumin, calcium, magnesium, uric acid and phosphate. Blood draws may be taken up to 3 days prior to dosing with CRS- 207 or 2 days prior to Cy. Clinical hematology and chemistry tests should be measured prior to each chemotherapy treatment. l Clinical hematology and chemistry tests to be taken prior to each chemotherapy treatment m Tumor markers to be assessed include mesothelin, CA- 125, and plasma osteopontin; other markers may also be assessed. n AEs and concomitant medications review. A phone call follow -up for AEs and concomitant medications will be conducted on day 3 ± 1 days after CRS -207 vaccination . o Up to 200 mL of whole blood should be processed within 6 hours into PBMCs and stored frozen in liquid nitrogen. p Whole blood (10 mL) will be collected between 20 and 26 hours after start of dosing f or assessment of Lm and mesothelin immunity. q The HLA -typing should include type A and B of class I antigens, low resolution. r Attempts to obtain surgical or biopsy archival tumor samples will be made for every subject until the sample is obtained or documentation that the sample cannot be obtained.