Remove and discard needle 8. Attach a new, sterile needle to the syringe containing 0.07 mL (100 µg) E75 acetate solution for intradermal administration CONFIDENTIAL Page 89 of 102 Protocol: HERCEPTIN® + E75/GM-CSF Version 3.1 ML25749 05 March 2017 APPENDIX H Leukine® Package Insert CONFIDENTIAL Page 90 of 102 Protocol: HERCEPTIN® + E75/GM-CSF Version 3.1 ML25749 05 March 2017 APPENDIX I Performance Status Criteria ECOG Performance Status Criteria Score Description 0 Fully active, able to carry on all pre-disease performance without restriction 1 Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light housework, office work 2 Ambulatory and capable of all self-care but unable to carry out any work activities. Up and about more than 50% of waking hours.