Figu re 1. Anti -tumor efficacy of DOTAP/E7 vs. CpG-E7 and CFA-E7 in C57BL/6J mice bearing TC-1 HPV+ tumors. Toxicology studies of R -DOTAP and a prototype R -DOTAP/HPV16 -E7 single peptide formulation were evaluated in rats and in non- human primates (monkeys). No deaths or clinical signs related to treatment were observed in any of the studies.