At least a 50% increase from nadir in the SPD of any previously involved nodes, or in a single involved node, or the size of other lesions (eg, splenic or hepatic nodules). To be considered PD, a lymph node with a diameter of the short axis of < 1.0 cm must increase by ≥50% and to a size of 1.5 ×1.5 cm or > 1.5 cm in the long axis. 3. At least a 50% increase in the longest diameter of any single previously identified node > 1 cm in its short axis.