Age ≥ 18 years. 4. Have an acceptable organ function: o Albumin ≥ 2.5 g/dL. o Total Bilirubin < 3.0 × upper limit of normal (ULN) unless patient has Gilbert’s syndrome. o Alanine transaminase (ALT) and aspartate transaminase (AST) ≤ 3.0 × ULN or ≤ 5 × ULN in the case of liver metastases. o Calculated or measured creatinine clearance > 35 mL/minute per the Cockcroft - Gault formula. o Absolute neutrophil count ≥ 1 ,500/mm3. o Hemoglobin ≥ 9 g/dL. o Platelet count ≥ 100,000/mm3. 5. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. 6.