It also does not completely ignore the possibility of antagonism because there is a 39% prior probability that γଵis less than 1. 5 DOSE RECOMMENDATION BY BLRM-COPULA FOR BMS-986226 IN COMBINATION COHORTS Similar to the dose escalation recommendati on for BMS-986226 monothe rapy, any recommended dose by BLRM Copula (for Parts B and C, and not to exceed the maximum administrated dose of the BMS-986226 monotherapy in Part A) and any potential dose recommendation for the combination cohorts will be based on the inferen ce from the Bayesian posterior and the probability (obtained from the BLRM- Copula model) that the true DLT r ate for each dose lies in 1 of the following categories: •[0%, 16%) under-dosing •[16%, 33%) targeted toxicity •[33%, 100%] excessive toxicity Revised Protocol No.: 04 Date: 31-May-2019 219 Approved 5.0 v Approved 1.0 v Clinical Protocol CA021002 BMS-986226 anti-ICOS While the Bayesian model w ill use DLT infor mation of all available data from the DLT period only, clinical assessment will take into considera tion of the totality of available data including PK/PD from all treated participants. BLRM-Copula Model-Recommended Dose: At any time a dose recommended by BLRM-Copula model for BMS-986226, using all av ailable data to date and time, is the dose that satisfies the following conditions: 1) Not to exceed the maximum administrated dose of BMS-986226 in Part A, ie., the BMS-986226 monotherapy phase 2) This probability of the true DLT rate falling in to the targeted toxicity interval, i.e., [16%, 33%), needs to be the largest (or be comparable to numerically the largest with negligible practical difference) among the dose levels that satisf y the EWOC condition (ie, the probability that ‘DLT rate ≥33%’) must be less than 30%; Final BLRM-Copula Recommended Dose: Any final recommended BLRM-Copula reco mmended dose will be based on the recommendation from the BLRM-copula and overall clinical assessment of all available safety, PK/PD, and efficacy data. Also, note that the dose recommendation by BLRM-Copula is a real-t ime on-going process, and can be done whenever new DLT information is available.