Common TRAEs were fever and injection site reactions, all grade 1 or 2. 14.1.5 Formulation and Preparation Each vaccine is supplied as a clear colorless liquid filled in a 2-mL amber vial at a concentration of 5x1011 total virus particles (VP) per 1.0 mL. Each vial is sealed with a rubber stopper and has a white flip off seal. End user of the product will need to flip the white plastic portion of the cap up/off with their thumb to expose the rubber stopper, and then puncture the stopper with an injection needle to withdraw the liquid. The rubber stopper is secured to the vial with an aluminum crimped seal. 76 Abbreviated Title: Neoadjuvant IO for HNSCC Version Date: August 31, 2022 14.1.6 Stability and Storage Individual vials (in the desired number) of vaccine will be packaged in a cardboard box and will be shipped over dry ice by overnight courier with a temperature monitoring device included. Upon receipt, one will inspect contents of package for any noticeable damages or defects.