However, this document may be disclosed to appropriate Institutional Revie w Board and Ethics Committees or duly authorized representatives of a national regulatory authority under the condition that they are requested to keep it confidential. In the event of an actual or suspected br each of this obligation, Sponsor should be notified promptly. DocuSign Envelope ID: B3F56764-C440-4885-BA44-7578C4A73DB3 Stemline Therapeutics, Inc. Protocol: STML- 701-0114 Version 3.0, 10-JUL-2015 (Amendment 2) Statistical Analysis Plan Page 2 of 63 Version: Final 1.0 Version Date: 31 August 2017 I confirm that I have reviewed this document and agree with the content. APPROVALS TCM Groups, Inc Michael Chen, PhD Statistician President Date (dd-Mmm- yyyy ) Stemline Therapeutics, Inc. Trishna Goswami, MD Senior Medical Director Date (dd-Mmm- yyyy ) Shay Shemesh, MS VP, Clinical and Regulatory Operations Date (dd-Mmm- yyyy) DocuSign Envelope ID: B3F56764-C440-4885-BA44-7578C4A73DB3 ＸＯＳＱＯＲＰＱＷ ＳＱ＠ａｵｧｵｳｴ＠ＲＰＱＷ ＳＱ＠ａｵｧｵｳｴ＠ＲＰＱＷ Stemline Therapeutics, Inc. Protocol: STML- 701-0114 Version 3.0, 10-JUL-2015 (Amendment 2) Statistical Analysis Plan Page 3 of 63 TABLE OF CONTENTS 1. GLOSSARY OF ABBREVIATIONS ................................................................