2005, Rasper, Jabar et al. 2014). In one large retrospective analysis of 714 patients in first relapse, the 1-year OS was 43%, 5-year OS was 13%, and 10-year OS was 9% (Stahl, Ranft et al. 2011). 1.3 Salvage chemotherapy in Ewing’s sarcoma Regimens such as topotecan/cyclophosphamide, irinotecan/temozolomide, or docetaxel/gemcitabine have been utilized in second line or later treatment and may prolong life for those who respond (Merchant, Kushner et al. 1999, Saylors, Stine et al.