Subjects may receive other medications that the investigator deems to be medically necessary. Abbreviated Title: mRNA-Based, Cancer Vaccine Version Date: January 23, 2019 355 BIOSPECIMEN COLLECTION Blood and tissue are tracked at the patient level and can be linked to all protocols on which the patient has been enrolled. Sample s will be used to support the sp ecific objectives listed in the treatment protocol(s), e.g., immunologic monitoring, cytokine levels, persistence, as well as to support long-term research efforts within the NC I-SB and with collaborators as specified in protocol 03-C-0277. The amount of blood that may be drawn from a dult patients for research purposes shall not exceed 10.5 mL/kg or 550 mL, whichever is smaller, over any eight-week period. Samples will be ordered in CRIS and tracked through the Clinical Trial Data Management system.