https:// doi. org/ 10. 1016/ s1470- 2045(20) 30110-8 29. André T, Shiu KK, Kim TW et al (2020) Pembrolizumab in micro- satellite-instability-high advanced colorectal cancer. N Engl J Med 383:2207–2218. https:// doi. org/ 10. 1056/ NEJMo a2017 699 30. Overman MJ, McDermott R, Leach JL et al (2017) Nivolumab in patients with metastatic DNA mismatch repair-deficient or micro- satellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol 18:1182– 1191. https:// doi. org/ 10. 1016/ s1470- 2045(17) 30422-9 31. Ding Z, Li Q, Zhang R et al (2021) Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer. Signal Transduct Target Ther 6:26. https:// doi. org/ 10.