Following enrollment, subjects will be registered and assigned a code in CTDB under which the limited demographic and clinical information will be stored. Only the code will be used on the specimens to electronically log the specimens using a task-specific bar-code technology software which has full security and audit functions consistent with NIH requirements. Samples and the limited demographic and clinical information will not contain PII. Data should be entered within 2 weeks of patient enrollment onto the protocol. The access to the code keys will be limited to those designated by the Primary Investigator and will be kept in a secured, locked location. Samples will be stored in freezers, liquid nitrogen containers or tissue cartridge shelves in the NIDCD Core laboratory, located in building 10 on the NIH campus, secured by locked doors. Access to samples from a protocol for research purposes will be by permission of the Principal Investigator of that protocol in order to be used (1) for research purposes associated with protocol objectives for which the samples were collected, or (2) for a new research activity following submission and IRB approval of a new protocol and consent, or (3) for use only as unlinked or linked samples under the Office of Human Subjects Research Protections (OHSRP) Exemption Form guidelines stipulating that the activity is exempt from IRB review. The use of all samples will be fully tracked and audit lists of when each sample was used and who used it can be generated upon need or request. Samples, and associated data, will be stored permanently unless the patient withdraws consent. If researchers have samples remaining once they have completed all studies associated with the protocol and patient consent has not been withdrawn, samples may be kept permanently for possible use in future IRB approved investigations. Once research objectives for the protocol are achieved, researchers can request access to remaining samples, providing they have both approval of the Principal Investigator of the original protocol under which the samples or data were collected and either an IRB approved protocol and patient consent or the OHSRP Exemption Form stipulating that the activity is exempt from IRB review. 5.2.3 Protocol Completion/Sample Destruction All specimens obtained in the protocol are used as defined in the protocol. Any specimens that are remaining at the completion of the protocol will be stored in the conditions described above. Samples from consenting subjects will be stored until they are no longer of scientific value or if a subject withdraws consent for their continued use, at which time they will be destroyed. If the patient withdraws consent, the participant’s data and specimens will be excluded from future distributions, but data and specimens that have already been distributed for approved research use will not be able to be retrieved. The PI will record any loss or unanticipated destruction of samples as a deviation.