He was the heir presumptive of Mecklenburg-Strelitz from the death of his father on 5 June 1752 until he succeeded his uncle Duke Adolphus Frederick III on 11 December 1752.
A fost moștenitor prezumptiv de Mecklenburg-Strelitz de la decesul tatălui său (5 iunie 1752) până când și-a succedat unchiul, Ducele Adolf Frederick al III-lea la 11 decembrie 1752.