According to some analyses however, Tupuxuara is closer to the Azhdarchidae (the group that includes the giant Texan form Quetzalcoatlus) than to Tapejara and its relatives.
Međutim, prema nekim analizama, Tupuxuara je bliža Azhdarchidaeima (grupi u koju spada i divovska vrsta iz Texasa, Quetzalcoatlus) nego rodu Tapejara i njezinim srodnicima.