The second Gigantour began during the third quarter of 2006; Megadeth again headlined, this time with Lamb of God, Opeth, Arch Enemy and Overkill.
Drugi je Gigantour počeo u trećoj četvrtini 2006.; Megadeth je ponovno bio glavni izvođač, ovaj put s Lamb of Godom, Opethom, Arch Enemyjem i Overkillom.