During the time of the third caliph Uthman, Aisha had a leading part in the opposition that grew against him, though she did not agree either with those responsible for his assassination nor with the party of Ali.
Tijekom vremena trećeg kalifa, Osmana, Ajša je imala vodeću ulogu u oporbi protiv njega, no nije se slagala ni s onima odgovornima za njegovo ubojsvo ni Alijevom stranom.