Issoufou was the Prime Minister of Niger from 1993 to 1994, President of the National Assembly from 1995 to 1996, and he has been a candidate in each presidential election since 1993.
Issoufou je bio premijer Niger od 1993. do 1994. , predsjednik Narodne skupštine od 1995. do 1996. godine, a bio je i kandidat na svim predsjedničkim izborima od 1993.