The band signed with Sire Records shortly before recording the album; Anodyne was Uncle Tupelo's only major label release until 89/93: An Anthology in 2002.
Sastav je netom prije snimanja potpisao ugovor sa Sire Recordsom; Anodyne je bilo jedino izdanje Uncle Tupela za veliku izdavačku kuću sve do 89/93: An Anthology 2002.