As his reformist zeal provoked resentment, he was compelled to return to Rome in 1550, where, after having been employed in several inquisitorial missions, he was elected to the commissariat of the Holy Office.
Kako je njegova reformistička revnost izazvala ogorčenost, biva primoran se vratiti u Rim, gdje je 1550. godine, nakon sudjelovanja u nekoliko inkvizitorskih misija imenovan u povjereništvo u kongregaciji za doktrinu vjere.