In September 2016, along with 14,000 others, al-Hathloul signed a petition to King Salman asking for the male guardianship system to be abolished.
U rujnu 2016. godine, zajedno s 14,000 drugih, Loujain al-Hathloul potpisala je peticiju kralju Salmanu kojom je tražila ukidanje sustava muškog skrbništva.