Taking place at nine fictional locations between 1935 and 2035, the story follows 18 characters' individual attempts at defeating their own foes and the "TimeSplitters" with whom they have sided.
Događa se na devet različitih izmišljenih lokacija između 1935. i 2035., i prati individualne pokušaje 18 likova da pobijede vlastite neprijatelje i "TimeSplitterse" s kojima su se udružili.