Dengue hemorrhagic fever and dengue shock syndrome were first noted in Central and South America in 1981, as DENV-2 was contracted by people who had previously been infected with DENV-1 several years earlier.
Denga hemoragijska vrućica i denga sindrom šoka prvi su put zabilježeni u Srednjoj i Južnoj Americi 1981., kad je došlo do reinfekcije virusom DENV-2 u ljudi koji su prethodno preboljeli zarazu virusom DENV-1.