Every opening of the show starts with an announcer saying, "Ladies and gentlemen, it's The Eric Andre Show!" before Andre destroys the backdrop, desk, and various furnishings as the opening song is played by the stage band.
Hver åbningen af showet starter med en speaker, der siger: "Ladies and gentlemen, it's The Eric Andre Show!", mens Andre ødelægger baggrunden, skrivebordet og forskellige møbler som åbningssang enspilles af bandet.