Fortnite is set in contemporary Earth, where the sudden appearance of a worldwide storm causes 98% of the world's population to disappear, and zombie-like creatures rise to attack the remainder.
Fortnite foregår i nutiden, hvor en pludselig verdensomspændende storm forårsager, at 98 % af verdens befolkning forsvinder, og zombie-lignende væsner rejser sig for at angribe resten.