His work has covered themes of galactic conflict (Forge of God books), artificial universes (The Way series), consciousness and cultural practices (Queen of Angels), and accelerated evolution (Blood Music, Darwin's Radio, and Darwin's Children).
Hans værker har dækket temaer så som galaktiske konflikter (Forge of God-bøgerne), kunstige universer (The Way-serien), bevidstheds- og kulturelle skikke (Queen of Angels) og forceret evolution (Blood Music, Darwin's Radio og Darwin's Children).