While many Renaissance artists eagerly accepted portrait commissions, a few artists refused them, most notably Raphael's rival Michelangelo, who instead undertook the huge commissions of the Sistine Chapel.
Mens mange renæssancekunstnere ivrigt accepterede portrætbestillinger, nægtede et par kunstnere dem, især Raphaels rival Michelangelo, som i stedet påtog sig de store bestillinger til det Sixtinske Kapel.