The show focuses equally on the relationships among Don Eppes, his brother Charlie Eppes, and their father, Alan Eppes (Judd Hirsch), and on the brothers' efforts to fight crime, usually in Los Angeles.
Serien handler både om forholdet mellem Don Eppes, hans bror Charlie Eppes og deres far, Alan Eppes (Judd Hirsch) og om brødrenes anstrengelser for at bekæmpe kriminalitet, oftest i Los Angeles.