Gamble died of cholera in Virgin Bay, Nicaragua, while en route to command of the Presidio of San Francisco, and is buried in Virgin Bay in the Virgin Grove Cemetery, a burial ground which has been flooded and obliterated by the waters of the Bay.
Gamble døde af kolera i Virgin Bay, Nicaragua, mens han var på vej til at overtage kommandoen over Presidio of San Francisco, og ligger begravet i Virgin Bay i Virgin Grove Cemetery, en gravplads, som er blevet oversvømmet og ødelagt af vandet i bugten.