The C-47 was vital to the success of many Allied campaigns, in particular those at Guadalcanal and in the jungles of New Guinea and Burma, where the C-47 (and its naval version, the R4D) made it possible for Allied troops to counter the mobility of the light-travelling Japanese Army.
C-47 var af vital betydning for sucessen af mange allierede kampagner, i særdeleshed Guadalcanal og i junglen på Ny Guinea og Burma, hvor C-47 (og flådens version, R4D) gjorde det muligt for de alierede tropper at matche de japanske troppers mobillitet.