A number of third-party exclusives were also shown, including the highly anticipated Metal Gear Solid 4: Guns of the Patriots, alongside other high-profile third-party titles such as Grand Theft Auto IV, Call of Duty 4: Modern Warfare, Assassin's Creed, Devil May Cry 4 and Resident Evil 5.
En række eksklusive tredjepartsspil blev også vist, deriblandt det længe ventede Metal Gear Solid 4: Guns of the Patriots, sammen med andre højtprofilerede tredjepartstitler såsom Grand Theft Auto 4, Call of Duty 4: Modern Warfare, Assassin's Creed, Devil May Cry 4 og Resident Evil 5.