However, in contrast to the abundance of protein enzymes in biological systems and the discovery of biological ribozymes in the 1980s, there are no known naturally occurring deoxyribozymes.
Men i modsætning til den rigelige mængde proteinenzymer i biologiske systemer, og opdagelsen af biologiske ribozymer i 1980'erne, findes der ingen kendte naturligt forekommende deoxyribozymer.