Paxinou made her debut at the Municipal Theatre of Piraeus in 1920 in the operatic version of Maurice Maeterlinck's Sister Beatrice, with a score by Dimitri Mitropoulos.
Paxinou gjorde sin debut på Piræus' kommunale teater i 1920 i den operative version af Maurice Maeterlincks Søster Beatrice med en score af Dimitri Mitropoulos.