Since his arrival in Hollywood, Werkheiser has landed several television and film roles, the biggest of which is that of Ned Bigby on Ned's Declassified School Survival Guide.
Siden hans ankomst i Hollywood, har Werkheiser medvirket i adskillige tv- og filmroller, hvoraf den mest kendte er rollen som Ned Bigby i Ned's Universalhåndbog i Skoleoverlevelse.