In 2006, Ruffalo starred in Clifford Odets' Awake and Sing! at the Belasco Theatre in New York, for which he was nominated for a Tony Award for Best Featured Actor in a Play.
I 2006, medvirkede Ruffalo i Clifford Odetss Awake and Sing! på Belasco Theater i New York, for hvilken han blev nomineret til en Tony Award i kategorien "Best Featured Actor in a Play".