The process of tau aggregation in the absence of mutations is not known but might result from increased phosphorylation, protease action or exposure to polyanions, such as glycosaminoglycans.
Processen med samling af tau ved fraværet af mutationer er ikke kendt, men er muligvis et resultat af øget fosforylering, protease-aktivering eller eksponering for polyanioner, såsom glykoaminoglycans.