In 1958, Daniel Koshland suggested a modification to the lock and key model: since enzymes are rather flexible structures, the active site is continuously reshaped by interactions with the substrate as the substrate interacts with the enzyme.
Induceret tilpasning I 1958 foreslog Daniel Koshland en modifikation til "lås og nøgle"-modellen: Eftersom enzymer er ret fleksible strukturer, forandres det aktive sæde til stadighed i takt med, at enzymet interagerer med substratet.