Walsingham was among the promoters of Francis Drake's profitable 1578–1581 circumnavigation of the world, correctly judging that Spanish possessions in the Pacific were vulnerable to attack.
Walsingham var blandt fortalerne for Francis Drakes profitable jordomsejling fra 1578–1581, og bedømte korrekt at de spanske besiddelser i Stillehavet var sårbare overfor angreb.