Homer has appeared, voiced by Castellaneta, in several other television shows, including the sixth season of American Idol where he opened the show; The Tonight Show with Jay Leno where he performed a special animated opening monologue for the July 24, 2007, edition; and the 2008 fundraising television special Stand Up to Cancer where he was shown having a colonoscopy.
Homer, med stemme af Castellaneta, har optrådt i flere andre tv-serier, herunder sjette sæson af American Idol, hvor han åbnede showet, The Tonight Show med Jay Leno, hvor han udførte en speciel animeret indledende monolog den 24. juli 2007 og 2008-velgørenhedsudsendelsen Stand Up to Cancer, hvor han blev vist mens han fik en koloskopi.