The first two (26-84 and 58-110) are essential for conformational folding; each joins an alpha helix of the first layer to a beta sheet of the second layer, forming a small hydrophobic core in its vicinity.
De første to (26-84 og 58-110) er essentielle for konformationel foldning; hver enkelt binder en alfahelix i det ene lag til en betaplade i det andet lag, hvormed en lille hydrofob kerne dannes.