The station was again closed with the construction of the Berlin Wall on 13 August 1961 and for decades became one of Berlin's ghost stations, as while both terminals of the Nord-Süd railway line were located in West Berlin, the station itself was located in the East.
Stationen nedlagdes igen med opførslen af Berlinmuren den 13. august 1961 og var i årtier en af Berlins spøgelsesstationer, eftersom begge endestationer på Nord-Süd jernbanelinjen befandt sig i Vestberlin, hvorimod selve stationen lå i Østberlin.