The story takes place in the fictional town of Bon Temps, Louisiana, two years after vampires have made their presence known to mankind, and follows telepathic waitress Sookie Stackhouse as she attempts to solve a series of murders that seem to be motivated by a hatred of vampires.
Historien foregår i den fiktive by Bon Temps i Louisiana, to år efter, at vampyrer har gjort deres tilstedeværelse kendt for menneskeheden, og følger telepatisk servitrice Sookie Stackhouse, mens hun forsøger at løse en række mord, der synes at være motiveret af et had til vampyrer.