The producers have stated that as the first season is about introducing the survivors and the second season is about the hatch, the third season is about the Others, a group of mysterious island inhabitants.
Producerne udtalte, at første sæson handlede om at introducere de overlevende, anden sæson handlede om lugen, der er en DHARMA-station, mens tredje sæson handlede om De Andre, en gruppe mystiske ø-indfødte.