Though no pharmacological treatments exist for PCS, doctors may prescribe medications used for symptoms that also occur in other conditions; for example, antidepressants are used for the depression that frequently follows mTBI.
Selvom der ikke eksisterer en farmakologisk behandling for PCS, udskriver læger medikamenter for symptomer der findes i andre lidelser; eksempelvis antidepressiver der bruges mod depression der ofte efterfølger mTBI.