In the 20th century, drug companies  created a slew of synthetic substances similar to these opiates, including heroin, hydrocodone,  oxycodone, and fentanyl.
No século XX, as empresas químicas criaram montes de substâncias sintéticas semelhantes a estes opiáceos, incluindo a heroína, a hidrocodona, a oxicodona e o fentanil.