Since 1980, accidental deaths  from opioid overdose have grown exponentially  in the United States, and opioid addictions have  also exploded around the world.
Sejak 1980, kematian tidak disengaja disebabkan overdosis opioid telah meningkat berlipat-lipat di Amerika Serikat (AS) dan kasus ketergantungan opioid juga membeludak di seluruh dunia.