Background#R##N#Over the last decade sensitivity analysis techniques have been shown to be very useful to analyse complex and high dimensional Systems Biology models. However, many of the currently available toolboxes have either used parameter sampling, been focused on a restricted set of model observables of interest, studied optimisation of a objective function, or have not dealt with multiple simultaneous model parameter changes where the changes can be permanent or temporary.
['Mirela Domijan', 'Paul E. Brown', 'Boris V. Shulgin', 'David A. Rand']
PeTTSy: a computational tool for perturbation analysis of complex systems biology models