Background and objectives#R##N#A computer-aided diagnosis (CAD) system based on quantitative magnetic resonance imaging (MRI) features was developed to evaluate the malignancy of diffuse gliomas, which are central nervous system tumors.#R##N#Methods#R##N#The acquired image database for the CAD performance evaluation was composed of 34 glioblastomas and 73 diffuse lower-grade gliomas. In each case, tissues enclosed in a delineated tumor area were analyzed according to their gray-scale intensities on MRI scans. Four histogram moment features describing the global gray-scale distributions of gliomas tissues and 14 textural features were used to interpret local correlations between adjacent pixel values. With a logistic regression model, the individual feature set and a combination of both feature sets were used to establish the malignancy prediction model.#R##N#Results#R##N#Performances of the CAD system using global, local, and the combination of both image feature sets achieved accuracies of 76%, 83%, and 88%, respectively. Compared to global features, the combined features had significantly better accuracy (p = 0.0213). With respect to the pathology results, the CAD classification obtained substantial agreement κ = 0.698, p < 0.001.#R##N#Conclusions#R##N#Numerous proposed image features were significant in distinguishing glioblastomas from lower-grade gliomas. Combining them further into a malignancy prediction model would be promising in providing diagnostic suggestions for clinical use.
['Kevin Li Chun Hsieh', 'Chung Ming Lo', 'Chih Jou Hsiao']
Computer-aided grading of gliomas based on local and global MRI features