Background#R##N#Sigma (σ) receptors are accepted as a particular receptor class consisting of two subtypes: sigma-1 (σ1) and sigma-2 (σ2). The two receptor subtypes have specific drug actions, pharmacological profiles and molecular characteristics. The σ2 receptor is overexpressed in several tumor cell lines, and its ligands are currently under investigation for their role in tumor diagnosis and treatment. The σ2 receptor structure has not been disclosed, and researchers rely on σ2 receptor radioligand binding assay to understand the receptor’s pharmacological behavior and design new lead compounds.
['Giovanni Nastasi', 'Carla Miceli', 'Valeria Pittalà', 'Maria Modica', 'Orazio Prezzavento', 'Giuseppe Romeo', 'Antonio Rescifina', 'Agostino Marrazzo', 'Emanuele Amata']
S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands