Background#R##N#Enteric Escherichia coli survives the highly acidic environment of the stomach through multiple acid resistance (AR) mechanisms. The most effective system, AR2, decarboxylates externally-derived glutamate to remove cytoplasmic protons and excrete GABA. The first described system, AR1, does not require an external amino acid. Its mechanism has not been determined. The regulation of the multiple AR systems and their coordination with broader cellular metabolism has not been fully explored.
['Patrícia Pontes de Aquino', 'Brent Honda', 'Suma Jaini', 'Anna Lyubetskaya', 'Krutika Hosur', 'Joanna G. Chiu', 'Iriny Ekladious', 'Dongjian Hu', 'Lin Jin', 'Marianna K. Sayeg', 'Arion I. Stettner', 'Julia Wang', 'Brandon G. Wong', 'Winnie S. Wong', 'Stephen Alexander', 'Cong Ba', 'Seth I. Bensussen', 'David B. Bernstein', 'Dana Braff', 'Susie S. Cha', 'Daniel I. Cheng', 'Jang Hwan Cho', 'Kenny Chou', 'James Chuang', 'D. Gastler', 'Daniel J. Grasso', 'John S. Greifenberger', 'Chen Guo', 'Anna K. Hawes', 'Divya V. Israni', 'Saloni R. Jain', 'Jessica Kim', 'Junyu Lei', 'Hao Li', 'David Li', 'Qian Li', 'Christopher P. Mancuso', 'Ning Mao', 'Salwa Masud', 'Cari L. Meisel', 'Mi J', 'Christine S. Nykyforchyn', 'Minhee Park', 'Hannah Peterson', 'Alfred K. Ramirez', 'Daniel S. Reynolds', 'Nae Gyune Rim', 'Jared C. Saffie', 'Hang Su', 'Wendell R. Su', 'Yaqing Su', 'Meng Sun', 'Meghan M. Thommes', 'Tao Tu', 'Nitinun Varongchayakul', 'Tyler E. Wagner', 'Benjamin H. Weinberg', 'Rouhui Yang', 'Anastasia Yaroslavsky', 'Christine Yoon', 'Yanyu Zhao', 'Alicia J. Zollinger', 'Anne M. Stringer', 'John W. Foster', 'Joseph T. Wade', 'Sahadaven Raman', 'Natasha Broude', 'Wilson W. Wong', 'James E. Galagan']
Coordinated regulation of acid resistance in Escherichia coli