Background#R##N#Mitochondria are a vital component of eukaryotic cells and their dysfunction is implicated in a large number of metabolic, degenerative and age-related human diseases. The mechanism or these disorders can be difficult to elucidate due to the inherent complexity of mitochondrial metabolism. To understand how mitochondrial metabolic dysfunction contributes to these diseases, a metabolic model of a human heart mitochondrion was created.
['Anthony C. Smith', 'Alan J. Robinson']
A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle