Background#R##N#A key challenge in understanding the molecular mechanisms that control gene regulation is the characterization of the specificity with which transcription factor proteins bind to specific DNA sequences. A number of computational approaches have been developed to examine these interactions, including simple mononucleotide and dinucleotide position weight matrix models.
['Rowan G. Zellers', 'Robert A. Drewell', 'Jacqueline M. Dresch']
MARZ: an algorithm to combinatorially analyze gapped n-mer models of transcription factor binding