Synaptic depression is a common form of short-term plasticity in the central and peripheral nervous systems. We show that in a network of two reciprocally connected neurons a single depressing synapse can produce two distinct oscillatory regimes. These distinct periodic behaviors can be studied by varying the maximal conductance, ¯ ginh, of the depressing synapse. For smallinh, the network has a short-period solution controlled by intrinsic cellular properties. For largeinh, the solution has a much longer period and is controlled by properties of the synapse. We show that in an intermediate range of ¯ ginh values both stable periodic solutions exist simultaneously. Thus the network can switch oscillatory modes either by changing ¯ ginh or, for fixed ¯ ginh, by changing initial conditions.
['Amitabha Bose', 'Yair Manor', 'Farzan Nadim']
BISTABLE OSCILLATIONS ARISING FROM SYNAPTIC DEPRESSION