PROSITE [Bairoch and Bucher (1994) Nucleic Acids Res., 22, 3583–3589; Hofmann et al. (1999) Nucleic Acids Res., 27, 215–219] is a method of identifying the functions of uncharacterized proteins translated from genomic or cDNA sequences. The PROSITE database (http://www.expasy.org/prosite/) consists of biologically significant patterns and profiles designed in such a way that with appropriate computational tools it can rapidly and reliably help to determine to which known family of proteins (if any) a new sequence belongs, or which known domain(s) it contains.
['Laurent Falquet', 'Marco Pagni', 'Philipp Bucher', 'Nicolas Hulo', 'Christian J. A. Sigrist', 'Kay Hofmann', 'Amos Marc Bairoch']
The PROSITE database, its status in 2002