Background#R##N#The large amount of completely sequenced genomes allows genomic context analysis to predict reliable functional associations between prokaryotic proteins. Major methods rely on the fact that genes encoding physically interacting partners or members of shared metabolic pathways tend to be proximate on the genome, to evolve in a correlated manner and to be fused as a single sequence in another organism.
['François Enault', 'Karsten Suhre', 'Jean-Michel Claverie']
Phydbac "Gene Function Predictor" : a gene annotation tool based on genomic context analysis