Point-of-use (PoU) biological/chemical assays are aimed to transform bulky laboratory instruments into easy-to-use lab-on-a-chip platforms, bringing down the cost, size, and sample-use by orders of magnitude [1,2]. Micro-Nuclear Magnetic Resonance (NMR) is a trail-blazing tool for target pinpointing, by utilizing functionalized magnetic nanoparticles (MNPs) as the probe [3]. Screening by micro-NMR is repeatable, versatile and low-cost as it is label- and washing-free for the samples, and immobilization-free for the electrodes. Herein, a high-sensitivity micro-NMR CMOS platform with magnetic (B)-field stabilization and thermal management is reported (Fig. 28.1.1). This handheld tool unifies multi-type assays (target detection, protein state analysis, and solvent-polymer dynamics), and is suitable for healthcare, food industry, and colloidal applications.
['Ka-Meng Lei', 'Hadi Heidari', 'Pui-In Mak', 'Franco Maloberti', 'Rui Paulo Martins']
28.1 A handheld 50pM-sensitivity micro-NMR CMOS platform with B-field stabilization for multi-type biological/chemical assays