Cancer is a complex disease in which a variety of phenomena interact over a wide range of spatial and temporal scales. In this article a theoretical framework will be introduced that is capable of linking together such processes to produce a detailed model of vascular tumour growth. The model is formulated as a hybrid cellular automaton and contains submodels that describe subcellular, cellular and tissue level features. Model simulations will be presented to illustrate the effect that coupling between these different elements has on the tumour's evolution and its response to chemotherapy.
['Helen M. Byrne', 'Markus R. Owen', 'Tomás Alarcón', 'Philip K. Maini']
Cancer disease: integrative modelling approaches