This paper presents a pain state transition model which accounts for constraints used in clinical trials. The pain transition state model is an approach for summarizing, presenting and modeling pain state transitions in a population. Data used are from the ibuprofen arm of a number of clinical trials measuring dental extraction pain. The data determine the state transition coefficients of the model. The pain process in the presence of an analgesic is thus fully characterized.
['Meyer Katzper']
Clinical trial factors in a pain transition state model