Background#R##N#Cyanobacteria are model microorganisms for the study of photosynthesis, carbon and nitrogen assimilation, evolution of plant plastids, and adaptability to environmental stresses. However, there has been no web-based server of their regulatory and signaling interaction networks to date. #R##N##R##N#Description#R##N#We report a database called SynechoNET with feasible protein-protein interactions. SynechoNET shows cyanobacterial domain-domain interactions, as well as their protein level interactions using the model cyanobacterium, Synechocystis sp. PCC 6803. The SynechoNET server predicts and produces protein-protein interactions based on a structural information database, the PSIMAP server. The initial structure-based interaction prediction is further enriched with an extensive range of complementary interaction databases such as iPfam, InterDom, and STRING. The original genomic and proteomic resources of Synechocystis sp. PCC 6803 were from CyanoBase.#R##N##R##N#Conclusions#R##N#The resultant interacting partners of a query protein can be easily retrieved by SynechoNET users. Additionally, SynechoNET provides transmembrane topology and domain information, as well as the interaction networks in graphical web interfaces. Overall, this cyanobacteria-specific server is a valuable resource for extending the genomic data available. SynechoNET is freely available at http://synechocystis.org/ and directly at http://bioportal.kobic.re.kr/SynechoNET/.
['Sungsoo Kang', 'Woo-Yeon Kim', 'Byoung-Chul Kim', 'Ji-Hyun Oh', 'Jong Bhak', 'Jong-Soon Choi']
SynechoNET: integrated protein-protein interaction database of a model cyanobacterium Synechocystis sp. PCC 6803