Summary: We have written a fast implementation of the popular Neighbor-Joining tree building algorithm. QuickTree allows the reconstruction of phylogenies for very large protein families (including the largest Pfam alignment containing 27 000 HIV GP120 glycoprotein sequences) that would be infeasible using other popular methods. Availability: The source-code for QuickTree, written in ANSI C, is freely available via the world wide web at
['Kevin L. Howe', 'Alex Bateman', 'Richard Durbin']
QuickTree: building huge Neighbour-Joining trees of protein sequences