Recently an article published in Molecular Cell reveals the mechanism of a nuclear N6-methyladenosine (m6A) reader, the YTH domain-containing protein 1 (YTHDC1), in regulating pre-mRNA splicing [1]. Meanwhile, two additional articles published in Nature and Nature Chemical Biology report the first transcriptome-wide maps of N1-methyladenosine (m1A) at high resolution, suggesting a functional role for m1A in translation regulation [2], [3].
['Ye Wang', 'Guifang Jia']
New Edges of RNA Adenosine Methylation Modifications.