Finding the location of binding sites in DNA is a difficult problem. Although the location of some binding sites have been experimentally identified, other parts of the genome may or may not contain binding sites. This poses problems with negative data in a trainable classifier. Here we show that using randomized negative data gives a large boost in classifier performance when compared to the original labeled data.
['Faisal Rezwan', 'Yi Sun', 'Neil Davey', 'Rod Adams', 'Alistair G. Rust', 'Mark Robinson']
Using Randomised Vectors in Transcription Factor Binding Site Predictions