Background#R##N#Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are tolerated. The rise in available protein sequences continues to increase the power of techniques based on this principle.
['Jonathan R Manning', 'Emily R. Jefferson', 'Geoffrey J. Barton']
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction