The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and short linear motifs. The latter are involved in protein interactions and formation of regulatory complexes. The function of such proteins, which may be difficult to define, is the aggregate of the subfunctions of the modules. It is therefore desirable to efficiently predict linear motifs with some degree of accuracy, yet sequence database searches return results that are not significant.
['Claudia Chica', 'Alberto Labarga', 'Cathryn M. Gould', 'Rodrigo Lopez', 'Toby J. Gibson']
A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences