It is well known that the %broblast–collagen-matrix contraction model is a unique way to study mechanical interactions that regulate wound contraction of connective tissue cells. This contraction, due to cell traction, plays important roles in wound healing and pathological contractures. A continuum model initially used for the study of mesenchymal morphogenesis is revisited and numerically investigated by assuming that the extracellular matrix has adaptive-elastic properties. The set of non-linear partial di7erential equations is solved numerically by a %nite di7erence method and the obtained results are discussed. ? 2002 Elsevier Science Ltd. All rights reserved.
['S. Ramtani', 'E. Fernandes-Morin', 'D. Geiger']
Remodeled-matrix contraction by fibroblasts: numerical investigations