Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: In participation of the fifth statistical assessment of modeling of proteins and ligands (SAMPL5), the strength of association of six guests (3–8) to two hosts (1 and 2) re measured by 1H NMR and ITC. Each host possessed a unique and ll-defined binding pocket, whilst the wide array of amphiphilic guests possessed binding moieties that included: a terminal alkyne, nitro-arene, alkyl halide and cyano-arene groups. Solubilizing head groups for the guests included both positively charged trimethylammonium and negatively charged carboxylate functionality. Measured association constants (Ka) covered five orders of magnitude, ranging from 56 M−1 for guest 6 binding with host 2 up to 7.43 × 106 M−1 for guest 6 binding to host 1.
['Matthew R. Sullivan', 'Punidha Sokkalingam', 'Thong Nguyen', 'James P. Donahue', 'Bruce C. Gibb']
I am writing a research paper on a idea Binding of carboxylate and trimethylammonium salts to octa-acid and TEMOA deep-cavity cavitands
[{"from": "human", "value": "I am writing a research paper on a idea Binding of carboxylate and trimethylammonium salts to octa-acid and TEMOA deep-cavity cavitands"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: In participation of the fifth statistical assessment of modeling of proteins and ligands (SAMPL5), the strength of association of six guests (3\u20138) to two hosts (1 and 2) re measured by 1H NMR and ITC. Each host possessed a unique and ll-defined binding pocket, whilst the wide array of amphiphilic guests possessed binding moieties that included: a terminal alkyne, nitro-arene, alkyl halide and cyano-arene groups. Solubilizing head groups for the guests included both positively charged trimethylammonium and negatively charged carboxylate functionality. Measured association constants (Ka) covered five orders of magnitude, ranging from 56 M\u22121 for guest 6 binding with host 2 up to 7.43 \u00d7 106 M\u22121 for guest 6 binding to host 1."}]