Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely:  aimed to determine practical constraints on the estimation of the spatial extent of neuronal activation using MEG beamformers. Correct estimation of spatial extent is a pre-requisite for accurate models of electrical activity, allows one to estimate current density, and enables non-invasive monitoring of functional recovery following stroke.#R##N##R##N#The output of an MEG beamformer is maximum when the correct source model is used, so that the spatial extent of a source can in principal be determined through evaluation of different source models with the beamformer. Here,  simulated 275-channel MEG data using sources of varying spatial extents that follod the cortical geometry. These data re subsequently used to estimate the spatial extent of generic disc elements without knowledge of the underlying surface, and  compared these results to estimates based on cortical surface geometry (with and without error in surface location).#R##N##R##N# found that disc-shaped source models are too simplistic, particularly for areas with high curvature. For areas with low curvature spatial extent was underestimated, although on average there was a linear relationship beten the true and estimated extent. In contrast, cortical surface models gave accurate predictions of spatial extent. Hover, adding small errors (> 2 mm) to the estimated location of the cortical surface abolished this relationship beten true and estimated extent, implying that accurate co-registration is needed with such models.#R##N##R##N#Our results show that models exploiting surface information are necessary in order to model spatial extent and in turn current density, but in order to render such models applicable in practical situations, the accuracy of the cortical surface model itself needs to improve.
['Arjan Hillebrand', 'Gareth R. Barnes']
I am writing a research paper on a idea Practical constraints on estimation of source extent with MEG beamformers
[{"from": "human", "value": "I am writing a research paper on a idea Practical constraints on estimation of source extent with MEG beamformers"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely:  aimed to determine practical constraints on the estimation of the spatial extent of neuronal activation using MEG beamformers. Correct estimation of spatial extent is a pre-requisite for accurate models of electrical activity, allows one to estimate current density, and enables non-invasive monitoring of functional recovery following stroke.#R##N##R##N#The output of an MEG beamformer is maximum when the correct source model is used, so that the spatial extent of a source can in principal be determined through evaluation of different source models with the beamformer. Here,  simulated 275-channel MEG data using sources of varying spatial extents that follod the cortical geometry. These data re subsequently used to estimate the spatial extent of generic disc elements without knowledge of the underlying surface, and  compared these results to estimates based on cortical surface geometry (with and without error in surface location).#R##N##R##N# found that disc-shaped source models are too simplistic, particularly for areas with high curvature. For areas with low curvature spatial extent was underestimated, although on average there was a linear relationship beten the true and estimated extent. In contrast, cortical surface models gave accurate predictions of spatial extent. Hover, adding small errors (>\u00a02\u00a0mm) to the estimated location of the cortical surface abolished this relationship beten true and estimated extent, implying that accurate co-registration is needed with such models.#R##N##R##N#Our results show that models exploiting surface information are necessary in order to model spatial extent and in turn current density, but in order to render such models applicable in practical situations, the accuracy of the cortical surface model itself needs to improve."}]