Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Summary: ESTvier is a b application for interactively visualizing human gene structures, with emphasis on mammalian and avian expressed sequence tags (ESTs) that are conserved in the human genome and alternatively spliced (AS) variants. AS variants from the UCSC, Vega and PSEP annotations are presented in this application for comparison. EST data from six species, human, mouse, rat, cattle, pig and chicken, are mapped to the human genome to show cross-species EST conservation in annotated exonic and intronic regions. Cross-species EST conservation is evolutionarily and functionally important because it represents the effects of selection pressure on genic regions and transcriptome over evolutionary time. Emphatically, ESTvier provides a convenient tool to compare highly conserved non-human ESTs and human AS variants. The application takes human gene accession Ids or coordinates of genomic sequences as inputs and presents annotated gene structures and their AS variants. In addition, the lengths and percentages of human genic regions covered by ESTs are displayed to show the level of EST coverage of different species. The percentages of the UCSC, Vega and PSEP annotated exons covered by ESTs of the six studied species are also displayed in the interface.#R##N##R##N#Availability: The ESTvier b interface is publicly accessible at http://www.gate.sinica.edu.tw/~trees/ESTvier/ESTvier.htm#R##N##R##N#Contact: trees@gate.sinica.edu.tw#R##N##R##N#Supplementary information: Detailed documentation and the data sets, including the whole human genome annotation of PSEP and 6-species ESTs conserved in the human genome, can be found on the ESTvier home page.
['Feng-Chi Chen', 'Trees-Juen Chuang']
I am writing a research paper on a idea ESTviewer: a web interface for visualizing mouse, rat, cattle, pig and chicken conserved ESTs in human genes and human alternatively spliced variants
[{"from": "human", "value": "I am writing a research paper on a idea ESTviewer: a web interface for visualizing mouse, rat, cattle, pig and chicken conserved ESTs in human genes and human alternatively spliced variants"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Summary: ESTvier is a b application for interactively visualizing human gene structures, with emphasis on mammalian and avian expressed sequence tags (ESTs) that are conserved in the human genome and alternatively spliced (AS) variants. AS variants from the UCSC, Vega and PSEP annotations are presented in this application for comparison. EST data from six species, human, mouse, rat, cattle, pig and chicken, are mapped to the human genome to show cross-species EST conservation in annotated exonic and intronic regions. Cross-species EST conservation is evolutionarily and functionally important because it represents the effects of selection pressure on genic regions and transcriptome over evolutionary time. Emphatically, ESTvier provides a convenient tool to compare highly conserved non-human ESTs and human AS variants. The application takes human gene accession Ids or coordinates of genomic sequences as inputs and presents annotated gene structures and their AS variants. In addition, the lengths and percentages of human genic regions covered by ESTs are displayed to show the level of EST coverage of different species. The percentages of the UCSC, Vega and PSEP annotated exons covered by ESTs of the six studied species are also displayed in the interface.#R##N##R##N#Availability: The ESTvier b interface is publicly accessible at http://www.gate.sinica.edu.tw/~trees/ESTvier/ESTvier.htm#R##N##R##N#Contact: trees@gate.sinica.edu.tw#R##N##R##N#Supplementary information: Detailed documentation and the data sets, including the whole human genome annotation of PSEP and 6-species ESTs conserved in the human genome, can be found on the ESTvier home page."}]