Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Detecting copy number variants (CNVs) is an essential part in variant calling process. Here,  describe a novel method ERDS-pe to detect CNVs from whole-exome sequencing (WES) data. ERDS-pe first employs principal component analysis to normalize WES data. Then, ERDS-pe incorporates read depth signal and single-nucleotide variation information together as a hybrid signal into a paired hidden Markov model to infer CNVs from WES data. Experimental results on real human WES data show that ERDS-pe demonstrates higher sensitivity and provides comparable or even better specificity than other tools. ERDS-pe is publicly available at: https://github.com/microtan0902/erds-pe.
['Renjie Tan', 'Jixuan Wang', 'Xiaoliang Wu', 'Guoqiang Wan', 'Rongjie Wang', 'Rui Ma', 'Zhijie Han', 'Wenyang Zhou', 'Shuilin Jin', 'Qinghua Jiang', 'Yadong Wang']
I am writing a research paper on a idea ERDS-pe: A paired hidden Markov model for copy number variant detection from whole-exome sequencing data
[{"from": "human", "value": "I am writing a research paper on a idea ERDS-pe: A paired hidden Markov model for copy number variant detection from whole-exome sequencing data"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Detecting copy number variants (CNVs) is an essential part in variant calling process. Here,  describe a novel method ERDS-pe to detect CNVs from whole-exome sequencing (WES) data. ERDS-pe first employs principal component analysis to normalize WES data. Then, ERDS-pe incorporates read depth signal and single-nucleotide variation information together as a hybrid signal into a paired hidden Markov model to infer CNVs from WES data. Experimental results on real human WES data show that ERDS-pe demonstrates higher sensitivity and provides comparable or even better specificity than other tools. ERDS-pe is publicly available at: https://github.com/microtan0902/erds-pe."}]