Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: Presently available methodsthat usep-values to estimate orcontrolthefalsediscoveryrate(FDR)implicitlyassumethatp-values arecontinuouslydistributedandbasedontwo-sidedtests.Therefore,it is difficult to reliably estimate the FDR when p-values are discrete or based on one-sided tests. Results:AsimpleandrobustmethodtoestimatetheFDRisproposed. The proposed method does not rely on implicit assumptions that tests are two-sided or yield continuously distributed p-values. The proposed method is proven to be conservative and have desirable large-sample properties. In addition, the proposed method was among the best performers across a series of ‘real data simulations’ comparing the performance of five currently available methods. Availability:LibrariesofS-plusandRroutinestoimplementthemethod are freely available from www.stjuderesearch.org/depts/biostats Contact: stanley.pounds@stjude.org Supplementary information: Supplementary data are avilable at Bioinformatics online.
['Stan Pounds', 'Cheng Cheng']
I am writing a research paper on a idea Robust estimation of the false discovery rate.
[{"from": "human", "value": "I am writing a research paper on a idea Robust estimation of the false discovery rate."}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: Presently available methodsthat usep-values to estimate orcontrolthefalsediscoveryrate(FDR)implicitlyassumethatp-values arecontinuouslydistributedandbasedontwo-sidedtests.Therefore,it is difficult to reliably estimate the FDR when p-values are discrete or based on one-sided tests. Results:AsimpleandrobustmethodtoestimatetheFDRisproposed. The proposed method does not rely on implicit assumptions that tests are two-sided or yield continuously distributed p-values. The proposed method is proven to be conservative and have desirable large-sample properties. In addition, the proposed method was among the best performers across a series of \u2018real data simulations\u2019 comparing the performance of five currently available methods. Availability:LibrariesofS-plusandRroutinestoimplementthemethod are freely available from www.stjuderesearch.org/depts/biostats Contact: stanley.pounds@stjude.org Supplementary information: Supplementary data are avilable at Bioinformatics online."}]