Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: article i nfo Article history: Accepted 4 March 2013 Available online 14 March 2013 Non-invasive assessment of human neurotransmitter function is a highly valuable tool in clinical research. Despite the current interest in task-based pharmacological MRI (phMRI) for the assessment of neural corre- lates of serotonin (5-HT) function, test-retest reliability of this technique has not yet been established. Using a placebo-controlled crossover design,  aimed to examine the repeatability of task-related phMRI with a single dose of oral citalopram in tlve healthy female subjects. Since  re interested in the drug's effect on neural correlates of 5-HT related cognitive processes, a sensorimotor and an emotional face processing paradigm re used. For both paradigms,  found no significant effects of the oral citalopram challenge on task-positive brain activity with whole-brain analysis. With ROI-based analysis, there was a small effect of the challenge related to emotional processing in the amygdala, but this effect could not be reproduced beten sessions.didhover findreproducibleeffectsofthechallengeontask-negativeBOLD-responses,particularly in the medial frontal cortex and paracingulate gyrus. In conclusion, our data shows that a single oral dose of citalopram does not reliably affect emotional processing and sensorimotor activity, but does influence task-negative processes in the frontal cortex. This latter finding validates previous studies indicating a role for 5-HT in suppression of the task-negative network during goal-directed behavior.
['Anne Klomp', 'G.A. van Wingen', 'M. B. de Ruiter', 'Matthan W. A. Caan', 'D. Denys', 'Liesbeth Reneman']
I am writing a research paper on a idea Test-retest reliability of task-related pharmacological MRI with a single-dose oral citalopram challenge
[{"from": "human", "value": "I am writing a research paper on a idea Test-retest reliability of task-related pharmacological MRI with a single-dose oral citalopram challenge"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: article i nfo Article history: Accepted 4 March 2013 Available online 14 March 2013 Non-invasive assessment of human neurotransmitter function is a highly valuable tool in clinical research. Despite the current interest in task-based pharmacological MRI (phMRI) for the assessment of neural corre- lates of serotonin (5-HT) function, test-retest reliability of this technique has not yet been established. Using a placebo-controlled crossover design,  aimed to examine the repeatability of task-related phMRI with a single dose of oral citalopram in tlve healthy female subjects. Since  re interested in the drug's effect on neural correlates of 5-HT related cognitive processes, a sensorimotor and an emotional face processing paradigm re used. For both paradigms,  found no significant effects of the oral citalopram challenge on task-positive brain activity with whole-brain analysis. With ROI-based analysis, there was a small effect of the challenge related to emotional processing in the amygdala, but this effect could not be reproduced beten sessions.didhover findreproducibleeffectsofthechallengeontask-negativeBOLD-responses,particularly in the medial frontal cortex and paracingulate gyrus. In conclusion, our data shows that a single oral dose of citalopram does not reliably affect emotional processing and sensorimotor activity, but does influence task-negative processes in the frontal cortex. This latter finding validates previous studies indicating a role for 5-HT in suppression of the task-negative network during goal-directed behavior."}]