Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: This article summarizes our progress with RegulonDB (http://regulondb.ccg.unam.mx/) during the past 2 years.  have kept up-to-date the knowledge from the published literature regarding transcriptional regulation in Escherichia coli K-12.  have maintained and expanded our curation efforts to improve the breadth and quality of the encoded experimental knowledge, and  have implemented criteria for the quality of our computational predictions. Regulatory phrases now provide high-level descriptions of regulatory regions.  expanded the assignment of quality to various sources of evidence, particularly for knowledge generated through high-throughput (HT) technology. Based on our analysis of most relevant methods,  defined rules for determining the quality of evidence when multiple independent sources support an entry. With this latest release of RegulonDB,  present a new highly reliable larger collection of transcription start sites, a result of our experimental HT genome-wide efforts. These improvements, together with several novel enhancements (the tracks display, uploading format and curational guidelines), address the challenges of incorporating HT-generated knowledge into RegulonDB. Information on the evolutionary conservation of regulatory elements is also available now. Altogether, RegulonDB version 8.0 is a much better home for integrating knowledge on gene regulation from the sources of information currently available.
['Heladia Salgado', 'Martín Peralta-Gil', 'Socorro Gama-Castro', 'Alberto Santos-Zavaleta', 'Luis Muñiz-Rascado', 'Jair S. García-Sotelo', 'Verena Weiss', 'Hilda Solano-Lira', 'Irma Martínez-Flores', 'Alejandra Medina-Rivera', 'Gerardo Salgado-Osorio', 'Shirley Alquicira-Hernández', 'Kevin Alquicira-Hernández', 'Alejandra López-Fuentes', 'Liliana Porrón-Sotelo', 'Araceli M. Huerta', 'César Bonavides-Martínez', 'Yalbi Itzel Balderas-Martínez', 'Lucia Pannier', 'Maricela Olvera', 'Aurora Labastida', 'Verónica Jiménez-Jacinto', 'Leticia Vega-Alvarado', 'Víctor Del Moral-Chávez', 'Alfredo Hernández-Alvarez', 'Enrique Morett', 'Julio Collado-Vides']
I am writing a research paper on a idea RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more
[{"from": "human", "value": "I am writing a research paper on a idea RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: This article summarizes our progress with RegulonDB (http://regulondb.ccg.unam.mx/) during the past 2 years.  have kept up-to-date the knowledge from the published literature regarding transcriptional regulation in Escherichia coli K-12.  have maintained and expanded our curation efforts to improve the breadth and quality of the encoded experimental knowledge, and  have implemented criteria for the quality of our computational predictions. Regulatory phrases now provide high-level descriptions of regulatory regions.  expanded the assignment of quality to various sources of evidence, particularly for knowledge generated through high-throughput (HT) technology. Based on our analysis of most relevant methods,  defined rules for determining the quality of evidence when multiple independent sources support an entry. With this latest release of RegulonDB,  present a new highly reliable larger collection of transcription start sites, a result of our experimental HT genome-wide efforts. These improvements, together with several novel enhancements (the tracks display, uploading format and curational guidelines), address the challenges of incorporating HT-generated knowledge into RegulonDB. Information on the evolutionary conservation of regulatory elements is also available now. Altogether, RegulonDB version 8.0 is a much better home for integrating knowledge on gene regulation from the sources of information currently available."}]