Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The aim of this study was to quantify the effect of cardiac anisotropy in the activation-based inverse problem of electrocardiography. Differences of the patterns of simulated body surface potential maps for isotropic and anisotropic conditions re investigated with regard to activation time (AT) imaging of ventricular depolarization. AT maps re estimated by solving the nonlinear inverse ill-posed problem employing spatio-temporal regularization. Four different reference AT maps (sinus rhythm, right-ventricular and septal pacing, accessory pathway) re calculated with a bidomain theory based anisotropic finite-element heart model in combination with a cellular automaton. In this heart model a realistic fiber architecture and conduction system was implemented. Although the anisotropy has some effects on forward solutions, effects on inverse solutions are small indicating that cardiac anisotropy might be negligible for some clinical applications (e.g., imaging of focal events) of our AT imaging approach. The main characteristic events of the AT maps re estimated despite neglected electrical anisotropy in the inverse formulation. The worst correlation coefficient of the estimated AT maps was 0.810 in case of sinus rhythm. Hover, all characteristic events of the activation pattern re found. The results of this study confirm our clinical validation studies of noninvasive AT imaging in which cardiac anisotropy was neglected.
['R. Modre', 'Michael Seger', 'Gerald Fischer', 'Christoph Hintermüller', 'Dieter Hayn', 'Bernhard Pfeifer', 'Friedrich Hanser', 'Gunter Schreier', 'B. Tilg']
I am writing a research paper on a idea Cardiac anisotropy: is it negligible regarding noninvasive activation time imaging?
[{"from": "human", "value": "I am writing a research paper on a idea Cardiac anisotropy: is it negligible regarding noninvasive activation time imaging?"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The aim of this study was to quantify the effect of cardiac anisotropy in the activation-based inverse problem of electrocardiography. Differences of the patterns of simulated body surface potential maps for isotropic and anisotropic conditions re investigated with regard to activation time (AT) imaging of ventricular depolarization. AT maps re estimated by solving the nonlinear inverse ill-posed problem employing spatio-temporal regularization. Four different reference AT maps (sinus rhythm, right-ventricular and septal pacing, accessory pathway) re calculated with a bidomain theory based anisotropic finite-element heart model in combination with a cellular automaton. In this heart model a realistic fiber architecture and conduction system was implemented. Although the anisotropy has some effects on forward solutions, effects on inverse solutions are small indicating that cardiac anisotropy might be negligible for some clinical applications (e.g., imaging of focal events) of our AT imaging approach. The main characteristic events of the AT maps re estimated despite neglected electrical anisotropy in the inverse formulation. The worst correlation coefficient of the estimated AT maps was 0.810 in case of sinus rhythm. Hover, all characteristic events of the activation pattern re found. The results of this study confirm our clinical validation studies of noninvasive AT imaging in which cardiac anisotropy was neglected."}]