Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: A new method for measuring bone mineral density (BMD) of the tarsal and metatarsals is described using volumetric quantitative computed tomography (VQCT) in subjects with diabetes mellitus and peripheral neuropathy. VQCT images of a single foot re acquired twice from eight subjects (mean age 51 [11 SD], seven males, one female). The cortical shells of the seven tarsal and five metatarsal bones re identified and semiautomatically segmented from adjacent bones. Volume and BMD of each bone re measured separately from the two acquired scans for each subject. Whole-bone semiautomatic segmentation measurement errors re determined as the root mean square coefficient of variation for the volume and BMD of 0.8% and 0.9%, respectively. In addition to the whole-bone segmentation methods,  performed atlas-based partitioning of subregions within the second metatarsal for all subjects, from which the volumes and BMDs re obtained for each subregion. The subregion measurement BMD errors (root mean square coefficient of variation) within the shaft, proximal end, and distal end re shown to vary by approximately 1% beten the two scans of each subject. The new methods demonstrated large variations in BMDs beten the 12 bones of the foot within a subject and beten subjects, and beten subregions within the second metatarsal. These methods can provide an important outcome measure for clinical research trials investigating the effects of interventions, aging, or disease progression on bone loss, or gain, in individual foot bones.
['Paul K. Commean', 'Tao Ju', 'Lu Liu', 'David R. Sinacore', 'Mary K. Hastings', 'Michael J. Mueller']
I am writing a research paper on a idea Tarsal and Metatarsal Bone Mineral Density Measurement Using Volumetric Quantitative Computed Tomography
[{"from": "human", "value": "I am writing a research paper on a idea Tarsal and Metatarsal Bone Mineral Density Measurement Using Volumetric Quantitative Computed Tomography"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: A new method for measuring bone mineral density (BMD) of the tarsal and metatarsals is described using volumetric quantitative computed tomography (VQCT) in subjects with diabetes mellitus and peripheral neuropathy. VQCT images of a single foot re acquired twice from eight subjects (mean age 51 [11 SD], seven males, one female). The cortical shells of the seven tarsal and five metatarsal bones re identified and semiautomatically segmented from adjacent bones. Volume and BMD of each bone re measured separately from the two acquired scans for each subject. Whole-bone semiautomatic segmentation measurement errors re determined as the root mean square coefficient of variation for the volume and BMD of 0.8% and 0.9%, respectively. In addition to the whole-bone segmentation methods,  performed atlas-based partitioning of subregions within the second metatarsal for all subjects, from which the volumes and BMDs re obtained for each subregion. The subregion measurement BMD errors (root mean square coefficient of variation) within the shaft, proximal end, and distal end re shown to vary by approximately 1% beten the two scans of each subject. The new methods demonstrated large variations in BMDs beten the 12 bones of the foot within a subject and beten subjects, and beten subregions within the second metatarsal. These methods can provide an important outcome measure for clinical research trials investigating the effects of interventions, aging, or disease progression on bone loss, or gain, in individual foot bones."}]