Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Summary: PPDMs is a resource that maps small molecule bioactivities to protein domains from the Pfam-A collection of protein families. Small molecule bioactivities mapped to protein domains add important precision to approaches that use protein sequence searches alignments to assist applications in computational drug discovery and systems and chemical biology.  have previously proposed a mapping heuristic for a subset of bioactivities stored in ChEMBL with the Pfam-A domain most likely to mediate small molecule binding.  have since refined this mapping using a manual procedure. Here,  present a resource that provides up-to-date mappings and the possibility to review assigned mappings as ll as to participate in their assignment and curation.  also describe how mappings provided through the PPDMs resource are made accessible through the main schema of the ChEMBL database.#R##N##R##N#Availability and implementation: The PPDMs resource and curation interface is available at https://www.ebi.ac.uk/chembl/research/ppdms/pfam_maps. The source-code for PPDMs is available under the Apache license at https://github.com/chembl/pfam_maps. Source code is available at https://github.com/chembl/pfam_map_loader to demonstrate the integration process with the main schema of ChEMBL.#R##N##R##N#Contact: ku.ca.ibe@opj
['F. Krüger', 'Anna Gaulton', 'Michał Nowotka', 'John P. Overington']
I am writing a research paper on a idea PPDMs—a resource for mapping small molecule bioactivities from ChEMBL to Pfam-A protein domains
[{"from": "human", "value": "I am writing a research paper on a idea PPDMs\u2014a resource for mapping small molecule bioactivities from ChEMBL to Pfam-A protein domains"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Summary: PPDMs is a resource that maps small molecule bioactivities to protein domains from the Pfam-A collection of protein families. Small molecule bioactivities mapped to protein domains add important precision to approaches that use protein sequence searches alignments to assist applications in computational drug discovery and systems and chemical biology.  have previously proposed a mapping heuristic for a subset of bioactivities stored in ChEMBL with the Pfam-A domain most likely to mediate small molecule binding.  have since refined this mapping using a manual procedure. Here,  present a resource that provides up-to-date mappings and the possibility to review assigned mappings as ll as to participate in their assignment and curation.  also describe how mappings provided through the PPDMs resource are made accessible through the main schema of the ChEMBL database.#R##N##R##N#Availability and implementation: The PPDMs resource and curation interface is available at https://www.ebi.ac.uk/chembl/research/ppdms/pfam_maps. The source-code for PPDMs is available under the Apache license at https://github.com/chembl/pfam_maps. Source code is available at https://github.com/chembl/pfam_map_loader to demonstrate the integration process with the main schema of ChEMBL.#R##N##R##N#Contact: ku.ca.ibe@opj"}]