Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#Constraint-based modeling is increasingly employed for metabolic network analysis. Its underlying assumption is that natural metabolic phenotypes can be predicted by adding physicochemical constraints to remove unrealistic metabolic flux solutions. The loopless-COBRA approach provides an additional constraint that eliminates thermodynamically infeasible internal cycles (or loops) from the space of solutions. This allows the prediction of flux solutions that are more consistent with experimental data. Hover, it is not clear if this approach over-constrains the models by removing non-loop solutions as ll.
['Elad Noor', 'Nathan E. Lewis', 'Ron Milo']
I am writing a research paper on a idea A proof for loop-law constraints in stoichiometric metabolic networks
[{"from": "human", "value": "I am writing a research paper on a idea A proof for loop-law constraints in stoichiometric metabolic networks"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#Constraint-based modeling is increasingly employed for metabolic network analysis. Its underlying assumption is that natural metabolic phenotypes can be predicted by adding physicochemical constraints to remove unrealistic metabolic flux solutions. The loopless-COBRA approach provides an additional constraint that eliminates thermodynamically infeasible internal cycles (or loops) from the space of solutions. This allows the prediction of flux solutions that are more consistent with experimental data. Hover, it is not clear if this approach over-constrains the models by removing non-loop solutions as ll."}]