Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Establishing structure–activity relationships (SARs) in hit identification during early stage drug discovery is important in accelerating hit confirmation and expansion.  describe the development of EnCore, a systematic molecular scaffold enumeration protocol using single atom mutations, to enhance the application of objective scaffold definitions and to enrich SAR information from analysis of high-throughput screening output. A list of 43 literature medicinal chemistry compound series, each containing a minimum of 100 compounds, published in the Journal of Medicinal Chemistry was collated to validate the protocol. Analysis using the top representative Level 1 scaffolds this list of literature compound series demonstrated that EnCore could mimic the scaffold exploration conducted when establishing SAR. When EnCore was applied to analyze an HTS library containing over 200 000 compounds,  observed that over 70% of the molecular scaffolds matched extant scaffolds within the library after enumeration. In ...
['N. Yi Mok', 'Nathan Brown']
I am writing a research paper on a idea Applications of Systematic Molecular Scaffold Enumeration to Enrich Structure–Activity Relationship Information
[{"from": "human", "value": "I am writing a research paper on a idea Applications of Systematic Molecular Scaffold Enumeration to Enrich Structure\u2013Activity Relationship Information"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Establishing structure\u2013activity relationships (SARs) in hit identification during early stage drug discovery is important in accelerating hit confirmation and expansion.  describe the development of EnCore, a systematic molecular scaffold enumeration protocol using single atom mutations, to enhance the application of objective scaffold definitions and to enrich SAR information from analysis of high-throughput screening output. A list of 43 literature medicinal chemistry compound series, each containing a minimum of 100 compounds, published in the Journal of Medicinal Chemistry was collated to validate the protocol. Analysis using the top representative Level 1 scaffolds this list of literature compound series demonstrated that EnCore could mimic the scaffold exploration conducted when establishing SAR. When EnCore was applied to analyze an HTS library containing over 200\u202f000 compounds,  observed that over 70% of the molecular scaffolds matched extant scaffolds within the library after enumeration. In ..."}]