Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Ketamine, an N-methyl-d-aspartate (NMDA) receptor glutamatergic antagonist, has been studied as a model of schizophrenia when applied in subanesthetic doses. In EEG studies, ketamine affects sensory gating and alters the oscillatory characteristics of neuronal signals in a complex manner.  investigated the effects of ketamine on in vivo recordings from the CA3 region of mouse hippocampus referenced to the ipsilateral frontal sinus using a paired-click auditory gating paradigm. One issue of particular interest was elucidating the effect of ketamine on background network activity, poststimulus evoked and induced activity.  find that ketamine attenuates the theta frequency band in both background activity and in poststimulus evoked activity. Ketamine also disrupts a late, poststimulus theta por reduction seen in control recordings. In the gamma frequency range, ketamine enhances both background and evoked por, but decreases relative induced por. These findings support a role for NMDA receptors in mediating the balance beten theta and gamma responses to sensory stimuli, with possible implications for dysfunction in schizophrenia.
['Maciej T. Lazarewicz', 'Richard S. Ehrlichman', 'Christina R. Maxwell', 'Michael J. Gandal', 'Leif H. Finkel', 'Steven J. Siegel']
I am writing a research paper on a idea Ketamine modulates theta and gamma oscillations
[{"from": "human", "value": "I am writing a research paper on a idea Ketamine modulates theta and gamma oscillations"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Ketamine, an N-methyl-d-aspartate (NMDA) receptor glutamatergic antagonist, has been studied as a model of schizophrenia when applied in subanesthetic doses. In EEG studies, ketamine affects sensory gating and alters the oscillatory characteristics of neuronal signals in a complex manner.  investigated the effects of ketamine on in vivo recordings from the CA3 region of mouse hippocampus referenced to the ipsilateral frontal sinus using a paired-click auditory gating paradigm. One issue of particular interest was elucidating the effect of ketamine on background network activity, poststimulus evoked and induced activity.  find that ketamine attenuates the theta frequency band in both background activity and in poststimulus evoked activity. Ketamine also disrupts a late, poststimulus theta por reduction seen in control recordings. In the gamma frequency range, ketamine enhances both background and evoked por, but decreases relative induced por. These findings support a role for NMDA receptors in mediating the balance beten theta and gamma responses to sensory stimuli, with possible implications for dysfunction in schizophrenia."}]