Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: In the present study, a series of novel maleimide derivatives re rationally designed and optimized, and their inhibitory activities against cyanobacteria class-II fructose-1,6-bisphosphate aldolase (Cy-FBA-II) and Synechocystis sp. PCC 6803 re further evaluated. The experimental results shod that the introduction of a bigger group (Br, Cl, CH3, or C6H3-o-F) on the pyrrole-2′,5′-dione ring resulted in a decrease in the Cy-FBA-II inhibitory activity of the hit compounds. Generally, most of the hit compounds with high Cy-FBA-II inhibitory activities could also exhibit high in vivo activities against Synechocystis sp. PCC 6803. Especially, compound 10 not only shows a high Cy-FBA-II activity (IC50 = 1.7 μM) but also has the highest in vivo activity against Synechocystis sp. PCC 6803 (EC50 = 0.6 ppm). Thus, compound 10 was selected as a representative molecule, and its probable interactions with the surrounding important residues in the active site of Cy-FBA-II re elucidated by the joint use of molecul...
['Xinya Han', 'Xiu-Yun Zhu', 'Shuaihua Zhu', 'Lin Wei', 'Zongqin Hong', 'Li Guo', 'Haifeng Chen', 'Bo Chi', 'Yan Liu', 'Lingling Feng', 'Yanliang Ren', 'Jian Wan']
I am writing a research paper on a idea A Rational Design, Synthesis, Biological Evaluation and Structure–Activity Relationship Study of Novel Inhibitors against Cyanobacterial Fructose-1,6-bisphosphate Aldolase
[{"from": "human", "value": "I am writing a research paper on a idea A Rational Design, Synthesis, Biological Evaluation and Structure\u2013Activity Relationship Study of Novel Inhibitors against Cyanobacterial Fructose-1,6-bisphosphate Aldolase"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: In the present study, a series of novel maleimide derivatives re rationally designed and optimized, and their inhibitory activities against cyanobacteria class-II fructose-1,6-bisphosphate aldolase (Cy-FBA-II) and Synechocystis sp. PCC 6803 re further evaluated. The experimental results shod that the introduction of a bigger group (Br, Cl, CH3, or C6H3-o-F) on the pyrrole-2\u2032,5\u2032-dione ring resulted in a decrease in the Cy-FBA-II inhibitory activity of the hit compounds. Generally, most of the hit compounds with high Cy-FBA-II inhibitory activities could also exhibit high in vivo activities against Synechocystis sp. PCC 6803. Especially, compound 10 not only shows a high Cy-FBA-II activity (IC50 = 1.7 \u03bcM) but also has the highest in vivo activity against Synechocystis sp. PCC 6803 (EC50 = 0.6 ppm). Thus, compound 10 was selected as a representative molecule, and its probable interactions with the surrounding important residues in the active site of Cy-FBA-II re elucidated by the joint use of molecul..."}]