Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Menthol is a widely used penetration enhancer in clinical medicine due to its high efficiency and relative safety. Hover, details of the penetration enhancement mechanism of menthol on molecular level is rarely involved in the discussion. In this work, the penetration enhancement (PE) mechanism of menthol is explored by a multiscale method containing molecular dynamics simulations, in vitro penetration experiments and transmission electron microscopy. Osthole is chosen to be the tested drug due to its common-using in external preparations and its representative-accompanying with menthol as a PE in the preparations. The results show that menthol in each testing concentration can impair the lipids packing of stratum corneum (SC) and promote osthole permeating into SC, and the penetration promoting effect has the optimal concentration. In the low concentration, menthol causes the bilayer floppier with reduction in thickness and increment in lipid head group area. In the high concentration, menthol destroys...
['Shufang Yang', 'Ran Wang', 'Guang Wan', 'Zhimin Wu', 'Shujuan Guo', 'Xingxing Dai', 'Xinyuan Shi', 'Yanjiang Qiao']
I am writing a research paper on a idea A Multiscale study on the penetration enhancement mechanism of menthol to osthole
[{"from": "human", "value": "I am writing a research paper on a idea A Multiscale study on the penetration enhancement mechanism of menthol to osthole"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Menthol is a widely used penetration enhancer in clinical medicine due to its high efficiency and relative safety. Hover, details of the penetration enhancement mechanism of menthol on molecular level is rarely involved in the discussion. In this work, the penetration enhancement (PE) mechanism of menthol is explored by a multiscale method containing molecular dynamics simulations, in vitro penetration experiments and transmission electron microscopy. Osthole is chosen to be the tested drug due to its common-using in external preparations and its representative-accompanying with menthol as a PE in the preparations. The results show that menthol in each testing concentration can impair the lipids packing of stratum corneum (SC) and promote osthole permeating into SC, and the penetration promoting effect has the optimal concentration. In the low concentration, menthol causes the bilayer floppier with reduction in thickness and increment in lipid head group area. In the high concentration, menthol destroys..."}]