Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Mathematical models of the excitatory synapse are furnishing valuable information about the synaptic response. Based on Brownian-diffusion of glutamate molecules, a synapse model was utilized to investigate the synaptic response on a femto-second time scale by the use of a parallel computer. In particular, the presence of fibrils crossing the synaptic cleft was simulated, which could have a role in shaping the brain activity. To this aim the model of synapse was modified by considering trans-synaptic filaments with diameters ranging from 7 nm to 3 nm, disposed on a grid with spacing of 14 nm or 8 nm. The simulation demonstrated that the presence of filaments induced an increase in the synaptic response, most likely linked to an increment in the probability of encounter beten glutamate molecules and receptors. The increase was small – from 5 to 20%, but metabolic and functional considerations provide substantive hints about the importance of these small changes for brain activity. Moreover, it was shown that the presence of filaments made more stable the response of the synapse to random variations of pre-synaptic elements. Originated by these computational results, some inferences about the biological bases of mind diseases such as autism, mental retardation and schizophrenia, are reported in the Discussion.
['Francesco Ventriglia']
I am writing a research paper on a idea Effect of filaments within the synaptic cleft on the response of excitatory synapses simulated by computer experiments
[{"from": "human", "value": "I am writing a research paper on a idea Effect of filaments within the synaptic cleft on the response of excitatory synapses simulated by computer experiments"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Mathematical models of the excitatory synapse are furnishing valuable information about the synaptic response. Based on Brownian-diffusion of glutamate molecules, a synapse model was utilized to investigate the synaptic response on a femto-second time scale by the use of a parallel computer. In particular, the presence of fibrils crossing the synaptic cleft was simulated, which could have a role in shaping the brain activity. To this aim the model of synapse was modified by considering trans-synaptic filaments with diameters ranging from 7\u00a0nm to 3\u00a0nm, disposed on a grid with spacing of 14\u00a0nm or 8\u00a0nm. The simulation demonstrated that the presence of filaments induced an increase in the synaptic response, most likely linked to an increment in the probability of encounter beten glutamate molecules and receptors. The increase was small \u2013 from 5 to 20%, but metabolic and functional considerations provide substantive hints about the importance of these small changes for brain activity. Moreover, it was shown that the presence of filaments made more stable the response of the synapse to random variations of pre-synaptic elements. Originated by these computational results, some inferences about the biological bases of mind diseases such as autism, mental retardation and schizophrenia, are reported in the Discussion."}]