Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often indicative of structural and/or functional importance. ConSurf (http://consurf.tau.ac.il) and ConSeq (http://conseq.tau.ac.il) are two ll-established b servers for calculating the evolutionary conservation of amino acid positions in proteins using an empirical Bayesian inference, starting from protein structure and sequence, respectively. Here,  present the new version of the ConSurf b server that combines the two independent servers, providing an easier and more intuitive step-by-step interface, while offering the user more flexibility during the process. In addition, the new version of ConSurf calculates the evolutionary rates for nucleic acid sequences. The new version is freely available at: http://consurf.tau.ac.il/.
['Haim Ashkenazy', 'Erez E', 'Eric Martz', 'Tal Pupko', 'Nir Ben-Tal']
I am writing a research paper on a idea ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids.
[{"from": "human", "value": "I am writing a research paper on a idea ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids."}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often indicative of structural and/or functional importance. ConSurf (http://consurf.tau.ac.il) and ConSeq (http://conseq.tau.ac.il) are two ll-established b servers for calculating the evolutionary conservation of amino acid positions in proteins using an empirical Bayesian inference, starting from protein structure and sequence, respectively. Here,  present the new version of the ConSurf b server that combines the two independent servers, providing an easier and more intuitive step-by-step interface, while offering the user more flexibility during the process. In addition, the new version of ConSurf calculates the evolutionary rates for nucleic acid sequences. The new version is freely available at: http://consurf.tau.ac.il/."}]