Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely:  have recently introduced the “SQM/COSMO” scoring function which combines a semiempirical quantum mechanical description of noncovalent interactions at the PM6-D3H4X level and the COSMO implicit model of solvation. This approach outperformed standard scoring functions but faced challenges with a metalloprotein featuring a Zn2+···S– interaction. Here,  invoke SCC-DFTB3-D3H4, a higher-level SQM method, and observe improved behavior for the metalloprotein and high-quality results for the other systems. This method holds promise for diverse protein–ligand complexes including metalloproteins.
['Adam Pecina', 'Susanta Haldar', 'Jindřich Fanfrlík', 'René Meier', 'Jan Řezáč', 'Martin Lepšík', 'Pavel Hobza']
I am writing a research paper on a idea SQM/COSMO Scoring Function at the DFTB3-D3H4 Level: Unique Identification of Native Protein–Ligand Poses
[{"from": "human", "value": "I am writing a research paper on a idea SQM/COSMO Scoring Function at the DFTB3-D3H4 Level: Unique Identification of Native Protein\u2013Ligand Poses"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely:  have recently introduced the \u201cSQM/COSMO\u201d scoring function which combines a semiempirical quantum mechanical description of noncovalent interactions at the PM6-D3H4X level and the COSMO implicit model of solvation. This approach outperformed standard scoring functions but faced challenges with a metalloprotein featuring a Zn2+\u00b7\u00b7\u00b7S\u2013 interaction. Here,  invoke SCC-DFTB3-D3H4, a higher-level SQM method, and observe improved behavior for the metalloprotein and high-quality results for the other systems. This method holds promise for diverse protein\u2013ligand complexes including metalloproteins."}]