Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer’s disease (AD). Processing involves monomeric and dimeric forms of APP that traffic through distinct cellular compartments where the various secretases reside. Amyloidogenic processing is also influenced by modifiers such as sorting receptor-related protein (SORLA), an inhibitor of APP breakdown and major AD risk factor.
['Angelyn Lao', 'Vanessa Schmidt', 'Yvonne Schmitz', 'Thomas E. Willnow', 'Olaf Wolkenhauer']
I am writing a research paper on a idea Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease
[{"from": "human", "value": "I am writing a research paper on a idea Multi-compartmental modeling of SORLA\u2019s influence on amyloidogenic processing in Alzheimer\u2019s disease"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic A\u03b2 peptides, causative of neurodegeneration in Alzheimer\u2019s disease (AD). Processing involves monomeric and dimeric forms of APP that traffic through distinct cellular compartments where the various secretases reside. Amyloidogenic processing is also influenced by modifiers such as sorting receptor-related protein (SORLA), an inhibitor of APP breakdown and major AD risk factor."}]