Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: Combinatorial libraries of peptides such as those displayed on the surface of a bacteriophage particle have become widely used tools for characterizing protein– protein and protein–small molecule interactions. The quality of a library frequently depends on its completeness, or diversity—the proportion of possible sequences actually present in the library. The diversity of these libraries is frequently quoted on the basis of phage titers that provide little information about their completeness. Results: Here, an analytical expression for diversity is introduced and a method for estimating the diversity of a peptide library from the sequences of a limited number of the members of the library is demonstrated. The diversities of a number of computationally constructed and actual peptide libraries are estimated using this method.
['Lee Makowski', 'Alexei S. Soares']
I am writing a research paper on a idea Estimating the diversity of peptide populations from limited sequence data
[{"from": "human", "value": "I am writing a research paper on a idea Estimating the diversity of peptide populations from limited sequence data"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: Combinatorial libraries of peptides such as those displayed on the surface of a bacteriophage particle have become widely used tools for characterizing protein\u2013 protein and protein\u2013small molecule interactions. The quality of a library frequently depends on its completeness, or diversity\u2014the proportion of possible sequences actually present in the library. The diversity of these libraries is frequently quoted on the basis of phage titers that provide little information about their completeness. Results: Here, an analytical expression for diversity is introduced and a method for estimating the diversity of a peptide library from the sequences of a limited number of the members of the library is demonstrated. The diversities of a number of computationally constructed and actual peptide libraries are estimated using this method."}]