Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Network-based intervention has been a trend of curing systemic diseases, but it relies on regimen optimization and valid multi-target actions of the drugs. The complex multi-component nature of medicinal herbs may serve as valuable resources for network-based multi-target drug discovery due to its potential treatment effects by synergy. Recently, robustness of multiple systems biology platforms shows porful to uncover molecular mechanisms and connections beten the drugs and their targeting dynamic network. Hover, optimization methods of drug combination are insufficient, owning to lacking of tighter integration across multiple ‘-omics’ databases. The newly developed algorithm- or network-based computational models can tightly integrate ‘-omics’ databases and optimize combinational regimens of drug development, which encourage using medicinal herbs to develop into new wave of network-based multi-target drugs. Hover, challenges on further integration across the databases of medicinal herbs with multiple system biology platforms for multi-target drug optimization remain to the uncertain reliability of individual data sets, width and depth and degree of standardization of herbal medicine. Standardization of the methodology and terminology of multiple system biology and herbal database would facilitate the integration. Enhance public accessible databases and the number of research using system biology platform on herbal medicine would be helpful. Further integration across various ‘-omics’ platforms and computational tools would accelerate development of network-based drug discovery and network medicine.
['Elaine Lai-Han Leung', 'Zhiwei Cao', 'Zhi-Hong Jiang', 'Hua Zhou', 'Liang Liu']
I am writing a research paper on a idea Network-based drug discovery by integrating systems biology and computational technologies
[{"from": "human", "value": "I am writing a research paper on a idea Network-based drug discovery by integrating systems biology and computational technologies"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Network-based intervention has been a trend of curing systemic diseases, but it relies on regimen optimization and valid multi-target actions of the drugs. The complex multi-component nature of medicinal herbs may serve as valuable resources for network-based multi-target drug discovery due to its potential treatment effects by synergy. Recently, robustness of multiple systems biology platforms shows porful to uncover molecular mechanisms and connections beten the drugs and their targeting dynamic network. Hover, optimization methods of drug combination are insufficient, owning to lacking of tighter integration across multiple \u2018-omics\u2019 databases. The newly developed algorithm- or network-based computational models can tightly integrate \u2018-omics\u2019 databases and optimize combinational regimens of drug development, which encourage using medicinal herbs to develop into new wave of network-based multi-target drugs. Hover, challenges on further integration across the databases of medicinal herbs with multiple system biology platforms for multi-target drug optimization remain to the uncertain reliability of individual data sets, width and depth and degree of standardization of herbal medicine. Standardization of the methodology and terminology of multiple system biology and herbal database would facilitate the integration. Enhance public accessible databases and the number of research using system biology platform on herbal medicine would be helpful. Further integration across various \u2018-omics\u2019 platforms and computational tools would accelerate development of network-based drug discovery and network medicine."}]