Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: G → A hypermutation is an innate antiviral defense mechanism, mediated by host enzymes, which leads to the mutational impairment of viruses. Sensitive and specific identification of host-mediated G → A hypermutation is a novel sequence analysis challenge, particularly for viral deep sequencing studies. For example, two of the most common hepatitis B virus (HBV) reverse transcriptase (RT) drug-resistance mutations, A181T and M204I, arise from G → A changes and are routinely detected as low-abundance variants in nearly all HBV deep sequencing samples.#R##N##R##N#Results:  developed a classification model using measures of G → A excess and predicted indicators of lethal mutation and applied this model to 325 920 unique deep sequencing reads from plasma virus samples from 45 drug treatment-naive HBV-infected individuals. The 2.9% of sequence reads that re classified as hypermutated by our model included most of the reads with A181T and/or M204I, indicating the usefulness of this model for distinguishing viral adaptive changes from host-mediated viral editing.#R##N##R##N#Availability: Source code and sequence data are available at http://hivdb.stanford.edu/pages/resources.html.#R##N##R##N#Contact: ereuman@stanfordalumni.org#R##N##R##N#Supplementary information:Supplementary data are available at Bioinformatics online.
['Elizabeth C. Reuman', 'Severine Margeridon-Thermet', 'Harrison Caudill', 'Tommy F. Liu', 'Katyna Borroto-Esoda', 'Evguenia Svarovskaia', 'Susan Holmes', 'Robert W. Shafer']
I am writing a research paper on a idea A classification model for G-to-A hypermutation in hepatitis B virus ultra-deep pyrosequencing reads
[{"from": "human", "value": "I am writing a research paper on a idea A classification model for G-to-A hypermutation in hepatitis B virus ultra-deep pyrosequencing reads"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: G \u2192 A hypermutation is an innate antiviral defense mechanism, mediated by host enzymes, which leads to the mutational impairment of viruses. Sensitive and specific identification of host-mediated G \u2192 A hypermutation is a novel sequence analysis challenge, particularly for viral deep sequencing studies. For example, two of the most common hepatitis B virus (HBV) reverse transcriptase (RT) drug-resistance mutations, A181T and M204I, arise from G \u2192 A changes and are routinely detected as low-abundance variants in nearly all HBV deep sequencing samples.#R##N##R##N#Results:  developed a classification model using measures of G \u2192 A excess and predicted indicators of lethal mutation and applied this model to 325 920 unique deep sequencing reads from plasma virus samples from 45 drug treatment-naive HBV-infected individuals. The 2.9% of sequence reads that re classified as hypermutated by our model included most of the reads with A181T and/or M204I, indicating the usefulness of this model for distinguishing viral adaptive changes from host-mediated viral editing.#R##N##R##N#Availability: Source code and sequence data are available at http://hivdb.stanford.edu/pages/resources.html.#R##N##R##N#Contact: ereuman@stanfordalumni.org#R##N##R##N#Supplementary information:Supplementary data are available at Bioinformatics online."}]