Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: Heart failure affects more than 20 million people in the world. Heart transplantation is the most effective therapy, but the number of eligible patients far outighs the number of available donor hearts. The left mechanical ventricular assist device (LVAD) has been developed as a successful substitution therapy that aids the failing ventricle while a patient is waiting for the donor heart.  obtained genomics data from paired human heart samples harvested at the time of LVAD implant and explant. The heart failure patients in our study re supported by the LVAD for various periods of time. The goal of this study is to model the relationship beten the time of LVAD support and gene expression changes.#R##N##R##N#Results: To serve the purpose,  propose a novel penalized partial least squares (PPLS) method to build a regression model. Compared with partial least squares and Breiman's random forest method, PPLS gives the best prediction results for the LVAD data.
['Xiaohong Huang', 'Wei Pan', 'Soon J. Park', 'Xinqiang Han', 'Leslie W. Miller', 'Jennifer L. Hall']
I am writing a research paper on a idea Modeling the relationship between LVAD support time and gene expression changes in the human heart by penalized partial least squares
[{"from": "human", "value": "I am writing a research paper on a idea Modeling the relationship between LVAD support time and gene expression changes in the human heart by penalized partial least squares"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: Heart failure affects more than 20 million people in the world. Heart transplantation is the most effective therapy, but the number of eligible patients far outighs the number of available donor hearts. The left mechanical ventricular assist device (LVAD) has been developed as a successful substitution therapy that aids the failing ventricle while a patient is waiting for the donor heart.  obtained genomics data from paired human heart samples harvested at the time of LVAD implant and explant. The heart failure patients in our study re supported by the LVAD for various periods of time. The goal of this study is to model the relationship beten the time of LVAD support and gene expression changes.#R##N##R##N#Results: To serve the purpose,  propose a novel penalized partial least squares (PPLS) method to build a regression model. Compared with partial least squares and Breiman's random forest method, PPLS gives the best prediction results for the LVAD data."}]