Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Summary: Accurate alignment of protein sequences and/or structures is crucial for many biological analyses, including functional annotation of proteins, classifying protein sequences into families, and comparative protein structure modeling. Described here is a b interface to SALIGN, the versatile protein multiple sequence/structure alignment module of MODELLER. The b server automatically determines the best alignment procedure based on the inputs, while allowing the user to override default parameter values. Multiple alignments are guided by a dendrogram computed from a matrix of all pairwise alignment scores. When aligning sequences to structures, SALIGN uses structural environment information to place gaps optimally. If two multiple sequence alignments of related proteins are input to the server, a profile–profile alignment is performed. All features of the server have been previously optimized for accuracy, especially in the contexts of comparative modeling and identification of interacting protein partners.#R##N##R##N#Availability: The SALIGN b server is freely accessible to the academic community at http://salilab.org/salign. SALIGN is a module of the MODELLER software, also freely available to academic users (http://salilab.org/modeller).#R##N##R##N#Contact: gro.balilas@ilas; gs.ude.rats-a.iib@nahdusuhdam
['Hannes Braberg', 'Benjamin M. Webb', 'Elina Tjioe', 'Ursula Pieper', 'Andrej Sali', 'Mallur S. Madhusudhan']
I am writing a research paper on a idea SALIGN: a web server for alignment of multiple protein sequences and structures
[{"from": "human", "value": "I am writing a research paper on a idea SALIGN: a web server for alignment of multiple protein sequences and structures"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Summary: Accurate alignment of protein sequences and/or structures is crucial for many biological analyses, including functional annotation of proteins, classifying protein sequences into families, and comparative protein structure modeling. Described here is a b interface to SALIGN, the versatile protein multiple sequence/structure alignment module of MODELLER. The b server automatically determines the best alignment procedure based on the inputs, while allowing the user to override default parameter values. Multiple alignments are guided by a dendrogram computed from a matrix of all pairwise alignment scores. When aligning sequences to structures, SALIGN uses structural environment information to place gaps optimally. If two multiple sequence alignments of related proteins are input to the server, a profile\u2013profile alignment is performed. All features of the server have been previously optimized for accuracy, especially in the contexts of comparative modeling and identification of interacting protein partners.#R##N##R##N#Availability: The SALIGN b server is freely accessible to the academic community at http://salilab.org/salign. SALIGN is a module of the MODELLER software, also freely available to academic users (http://salilab.org/modeller).#R##N##R##N#Contact: gro.balilas@ilas; gs.ude.rats-a.iib@nahdusuhdam"}]