Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: One of the major properties of genes is their expression pattern. Notably, genes are often classified as tissue-specific or housekeeping. While many different methods of measuring tissue specificity have been proposed and used, there has been no comparison or benchmarking of these methods to our knowledge, and little justification of their use. In this study  compare nine measures of tissue-specificity. Most methods re established for ESTs and microarrays, and several re later adapted to RNA-seq.  analyze their capacity to distinguish gene categories, their robustness to the choice and number of tissues used, and their capture of evolutionary conservation signal.
['Nadezda Kryuchkova', 'Marc Robinson-Rechavi']
I am writing a research paper on a idea A benchmark of gene expression tissue-specificity metrics
[{"from": "human", "value": "I am writing a research paper on a idea A benchmark of gene expression tissue-specificity metrics"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: One of the major properties of genes is their expression pattern. Notably, genes are often classified as tissue-specific or housekeeping. While many different methods of measuring tissue specificity have been proposed and used, there has been no comparison or benchmarking of these methods to our knowledge, and little justification of their use. In this study  compare nine measures of tissue-specificity. Most methods re established for ESTs and microarrays, and several re later adapted to RNA-seq.  analyze their capacity to distinguish gene categories, their robustness to the choice and number of tissues used, and their capture of evolutionary conservation signal."}]