Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Aging is associated with declines in cognitive performance and multiple changes in the brain, including reduced default mode functional connectivity (FC). Hover, conflicting results have been reported regarding age differences in FC beten hippocampal and default mode regions. This discrepancy may stem from the variation in selection of hippocampal regions.  therefore examined the effect of age on resting state FC of anterior and posterior hippocampal regions in an adult life-span sample. Advanced age was associated with lor FC beten the posterior hippocampus and three regions: the posterior cingulate cortex, medial prefrontal cortex, and lateral parietal cortex. In addition, age-related reductions of FC beten the left and right posterior hippocampus, and bilaterally along the posterior to anterior hippocampal axis re noted. Age differences in medial prefrontal and inter-hemispheric FC significantly differed beten anterior and posterior hippocampus. Older age was associated with lor performance in all cognitive domains, but  observed no associations beten FC and cognitive performance after controlling for age.  observed a significant effect of gender and a linear effect of COMT val158met polymorphism on hippocampal FC. Females shod higher FC of anterior and posterior hippocampus and medial prefrontal cortex than males, and the dose of val allele was associated with lor posterior hippocampus – posterior cingulate FC, independent of age. Vascular and metabolic factors shod no significant effects on FC. These results suggest differential age-related reduction in the posterior hippocampal FC compared to the anterior hippocampus, and an age-independent effect of gender and COMT on hippocampal FC.
['Jessica S. Damoiseaux', 'Raymond Viviano', 'P. Yuan', 'Naftali Raz']
I am writing a research paper on a idea Differential effect of age on posterior and anterior hippocampal functional connectivity.
[{"from": "human", "value": "I am writing a research paper on a idea Differential effect of age on posterior and anterior hippocampal functional connectivity."}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Aging is associated with declines in cognitive performance and multiple changes in the brain, including reduced default mode functional connectivity (FC). Hover, conflicting results have been reported regarding age differences in FC beten hippocampal and default mode regions. This discrepancy may stem from the variation in selection of hippocampal regions.  therefore examined the effect of age on resting state FC of anterior and posterior hippocampal regions in an adult life-span sample. Advanced age was associated with lor FC beten the posterior hippocampus and three regions: the posterior cingulate cortex, medial prefrontal cortex, and lateral parietal cortex. In addition, age-related reductions of FC beten the left and right posterior hippocampus, and bilaterally along the posterior to anterior hippocampal axis re noted. Age differences in medial prefrontal and inter-hemispheric FC significantly differed beten anterior and posterior hippocampus. Older age was associated with lor performance in all cognitive domains, but  observed no associations beten FC and cognitive performance after controlling for age.  observed a significant effect of gender and a linear effect of COMT val158met polymorphism on hippocampal FC. Females shod higher FC of anterior and posterior hippocampus and medial prefrontal cortex than males, and the dose of val allele was associated with lor posterior hippocampus \u2013 posterior cingulate FC, independent of age. Vascular and metabolic factors shod no significant effects on FC. These results suggest differential age-related reduction in the posterior hippocampal FC compared to the anterior hippocampus, and an age-independent effect of gender and COMT on hippocampal FC."}]