Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Computational modeling of brain circuits requires the definition of many parameters that are difficult to determine from experimental findings. One way to help interpret these data is to fit them using a particular kinetic model. ,  propose a general procedure to fit individual synaptic events recorded from voltage clamp experiments. Starting from any given model description (mod file) in the NEURON simulation environment, the procedure exploits user-defined constraints, dependencies, and rules for the parameters of the model to fit the time course of individual spontaneous synaptic events that are recorded experimentally. The procedure, implemented in NEURON, is currently available in ModelDB. A Python version is installed, and will be soon available for public use, as a standalone task in the Collaboratory Portal of the Human Brain Project. To illustrate the potential application of the procedure,  tested its use with various sets of experimental data on GABAergic synapses; gephyrin and gephyrin-dependent pathways re chosen as a suitable example of a kinetic model of synaptic transmission. For individual spontaneous inhibitory events in hippocampal pyramidal CA1 neurons,  found that gephyrin-dependent subcellular pathways may shape synaptic events at different levels, and can be correlated with cell- or event-specific activity history and/or pathological conditions.
['Carmen Alina Lupascu', 'Annunziato Morabito', 'Elisabetta Merenda', 'Silvia Marinelli', 'Cristina Marchetti', 'Rosanna Migliore', 'Enrico Cherubini', 'Michele Migliore']
I am writing a research paper on a idea A General Procedure to Study Subcellular Models of Transsynaptic Signaling at Inhibitory Synapses
[{"from": "human", "value": "I am writing a research paper on a idea A General Procedure to Study Subcellular Models of Transsynaptic Signaling at Inhibitory Synapses"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Computational modeling of brain circuits requires the definition of many parameters that are difficult to determine from experimental findings. One way to help interpret these data is to fit them using a particular kinetic model. ,  propose a general procedure to fit individual synaptic events recorded from voltage clamp experiments. Starting from any given model description (mod file) in the NEURON simulation environment, the procedure exploits user-defined constraints, dependencies, and rules for the parameters of the model to fit the time course of individual spontaneous synaptic events that are recorded experimentally. The procedure, implemented in NEURON, is currently available in ModelDB. A Python version is installed, and will be soon available for public use, as a standalone task in the Collaboratory Portal of the Human Brain Project. To illustrate the potential application of the procedure,  tested its use with various sets of experimental data on GABAergic synapses; gephyrin and gephyrin-dependent pathways re chosen as a suitable example of a kinetic model of synaptic transmission. For individual spontaneous inhibitory events in hippocampal pyramidal CA1 neurons,  found that gephyrin-dependent subcellular pathways may shape synaptic events at different levels, and can be correlated with cell- or event-specific activity history and/or pathological conditions."}]