Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Metastatic cutaneous melanoma is an aggressive skin cancer with some progressionslowing treatments but no known cure. The omics data explosion has created many possible drug candidates, hover filtering criteria remain challenging, and systems biology approaches have become fragmented with many disconnected databases. Using drug, protein, and disease interactions,  built an evidence-ighted knowledge graph of integrated interactions. Our knowledge graph-based system, ReDrugS, can be used via an API or b interface, and has generated 25 high quality melanoma drug candidates.  show that probabilistic analysis of systems biology graphs increases drug candidate quality compared to non-probabilistic methods. Four of the 25 candidates are novel therapies, three of which have been tested with other cancers. All other candidates have current or completed clinical trials, or have been studied in in vivo or in vitro. This approach can be used to identify candidate therapies for use in research or personalized medicine.
['James P. McCusker', 'Michel Dumontier', 'Rui Yan', 'Sylvia He', 'Jonathan S. Dordick', 'Deborah L. McGuinness']
I am writing a research paper on a idea Finding melanoma drugs through a probabilistic knowledge graph
[{"from": "human", "value": "I am writing a research paper on a idea Finding melanoma drugs through a probabilistic knowledge graph"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Metastatic cutaneous melanoma is an aggressive skin cancer with some progressionslowing treatments but no known cure. The omics data explosion has created many possible drug candidates, hover filtering criteria remain challenging, and systems biology approaches have become fragmented with many disconnected databases. Using drug, protein, and disease interactions,  built an evidence-ighted knowledge graph of integrated interactions. Our knowledge graph-based system, ReDrugS, can be used via an API or b interface, and has generated 25 high quality melanoma drug candidates.  show that probabilistic analysis of systems biology graphs increases drug candidate quality compared to non-probabilistic methods. Four of the 25 candidates are novel therapies, three of which have been tested with other cancers. All other candidates have current or completed clinical trials, or have been studied in in vivo or in vitro. This approach can be used to identify candidate therapies for use in research or personalized medicine."}]