Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: article i nfo Article history: Accepted 8 January 2013 Available online 25 January 2013 Functional hyperemia Cerebral microvasculature Two photon fluorescence microscopy Cerebral blood volume The cortical microvessels are organized in an intricate, hierarchical, three-dimensional network. Superimposed on this anatomical complexity is the highly complicated signaling that drives the focal blood flow adjustments following a rise in the activity of surrounding neurons. The microvascular response to neuronal activation re- mains incompletely understood.  developed a custom two photon fluorescence microscopy acquisition and analysis to obtain 3D maps of neuronal activation-induced changes in the geometry of the microvascular net- work of the primary somatosensory cortex of anesthetized rats. An automated, model-based tracking algorithm was employed to reconstruct the 3D microvascular topology and represent it as a graph. The changes in the ge- ometry of this network re then tracked, over time, in the course of electrical stimulation of the contralateral forepaw. Both dilatory and constrictory responses re observed across the network. Early dilatory and late constrictory responses propagated from deeper to more superficial cortical layers while the response of the ver- tices that shod initial constriction follod by later dilation spread from cortical surface toward increasing cortical depths. Overall, larger caliber adjustments re observed deeper inside the cortex. This work yields the firstcharacterizationofthespatiotemporalpatternofgeometricchangesonthelevelofthecorticalmicrovas-
['Liis Lindvere', 'Rafal Janik', 'Adrienne Dorr', 'David Chartash', 'Bhupinder Sahota', 'John G. Sled', 'Bojana Stefanovic']
I am writing a research paper on a idea Cerebral microvascular network geometry changes in response to functional stimulation
[{"from": "human", "value": "I am writing a research paper on a idea Cerebral microvascular network geometry changes in response to functional stimulation"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: article i nfo Article history: Accepted 8 January 2013 Available online 25 January 2013 Functional hyperemia Cerebral microvasculature Two photon fluorescence microscopy Cerebral blood volume The cortical microvessels are organized in an intricate, hierarchical, three-dimensional network. Superimposed on this anatomical complexity is the highly complicated signaling that drives the focal blood flow adjustments following a rise in the activity of surrounding neurons. The microvascular response to neuronal activation re- mains incompletely understood.  developed a custom two photon fluorescence microscopy acquisition and analysis to obtain 3D maps of neuronal activation-induced changes in the geometry of the microvascular net- work of the primary somatosensory cortex of anesthetized rats. An automated, model-based tracking algorithm was employed to reconstruct the 3D microvascular topology and represent it as a graph. The changes in the ge- ometry of this network re then tracked, over time, in the course of electrical stimulation of the contralateral forepaw. Both dilatory and constrictory responses re observed across the network. Early dilatory and late constrictory responses propagated from deeper to more superficial cortical layers while the response of the ver- tices that shod initial constriction follod by later dilation spread from cortical surface toward increasing cortical depths. Overall, larger caliber adjustments re observed deeper inside the cortex. This work yields the firstcharacterizationofthespatiotemporalpatternofgeometricchangesonthelevelofthecorticalmicrovas-"}]