Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: A b service for analysis of protein structures that are sequentially or non-sequentially similar was generated. Recently, the non-sequential structure alignment algorithm GANGSTA+ was introduced. GANGSTA+ can detect non-sequential structural analogs for proteins stated to possess novel folds. Since GANGSTA+ ignores the polypeptide chain connectivity of secondary structure elements (i.e. α-helices and β-strands), it is able to detect structural similarities also beten proteins whose sequences re reshuffled during evolution. GANGSTA+ was applied in an all-against-all comparison on the ASTRAL40 database (SCOP version 1.75), which consists of >10 000 protein domains yielding about 55 × 106 possible protein structure alignments. Here,  provide the resulting protein structure alignments as a public b-based service, named GANGSTA+ Internet Services (GIS).  also allow to browse the ASTRAL40 database of protein structures with GANGSTA+ relative to an externally given protein structure using different constraints to select specific results. GIS allows us to analyze protein structure families according to the SCOP classification scheme. Additionally, users can upload their own protein structures for pairwise protein structure comparison, alignment against all protein structures of the ASTRAL40 database (SCOP version 1.75) or symmetry analysis. GIS is publicly available at http://agknapp.chemie.fu-berlin.de/gplus.
['Aysam Guerler', 'Ernst-Walter Knapp']
I am writing a research paper on a idea GIS: a comprehensive source for protein structure similarities
[{"from": "human", "value": "I am writing a research paper on a idea GIS: a comprehensive source for protein structure similarities"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: A b service for analysis of protein structures that are sequentially or non-sequentially similar was generated. Recently, the non-sequential structure alignment algorithm GANGSTA+ was introduced. GANGSTA+ can detect non-sequential structural analogs for proteins stated to possess novel folds. Since GANGSTA+ ignores the polypeptide chain connectivity of secondary structure elements (i.e. \u03b1-helices and \u03b2-strands), it is able to detect structural similarities also beten proteins whose sequences re reshuffled during evolution. GANGSTA+ was applied in an all-against-all comparison on the ASTRAL40 database (SCOP version 1.75), which consists of >10 000 protein domains yielding about 55 \u00d7 106 possible protein structure alignments. Here,  provide the resulting protein structure alignments as a public b-based service, named GANGSTA+ Internet Services (GIS).  also allow to browse the ASTRAL40 database of protein structures with GANGSTA+ relative to an externally given protein structure using different constraints to select specific results. GIS allows us to analyze protein structure families according to the SCOP classification scheme. Additionally, users can upload their own protein structures for pairwise protein structure comparison, alignment against all protein structures of the ASTRAL40 database (SCOP version 1.75) or symmetry analysis. GIS is publicly available at http://agknapp.chemie.fu-berlin.de/gplus."}]