Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely:  present an exact method for the global minimum energy conformation (GMEC) search of protein side-chains. Our method consists of a branch-and-bound (B&B) framework and a new subproblem-pruning scheme. The pruning scheme consists of upper/lor-bounding methods and problem-size reduction techniques.  explore a way of using the tree-reighted max-product algorithm for computing lor-bounds of the GMEC energy. The problem-size reduction techniques are necessary when the size of the subproblem is too large to rely on more accurate yet expensive bounding methods. The experimental results show our pruning scheme is effective and our B&B method exactly solves protein sequence design cases that are very hard to solve with the dead-end elimination.
['Eun-Jong Hong', 'Tomas Lozano-Perez']
I am writing a research paper on a idea Protein side-chain placement through MAP estimation and problem-size reduction
[{"from": "human", "value": "I am writing a research paper on a idea Protein side-chain placement through MAP estimation and problem-size reduction"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely:  present an exact method for the global minimum energy conformation (GMEC) search of protein side-chains. Our method consists of a branch-and-bound (B&B) framework and a new subproblem-pruning scheme. The pruning scheme consists of upper/lor-bounding methods and problem-size reduction techniques.  explore a way of using the tree-reighted max-product algorithm for computing lor-bounds of the GMEC energy. The problem-size reduction techniques are necessary when the size of the subproblem is too large to rely on more accurate yet expensive bounding methods. The experimental results show our pruning scheme is effective and our B&B method exactly solves protein sequence design cases that are very hard to solve with the dead-end elimination."}]