Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: ,  investigated adhesion force of a single cell on an extracellular matrix (ECM) by measuring shear force and detachment energy. As the ECM, fibronectin (FN) was employed. To measure the shear force,  have a developed direct measurement system based on atomic force microscopy (AFM). An AFM microcantilever was mounted vertically with respect to a substrate, and a single cell on the substrate was laterally pushed and dragged by the cantilever until the cell was detached from the substrate. From the deflection of the cantilever during the cell detachment, the shear force was measured. Furthermore, to measure cell adhesion force, the cantilever was mounted horizontally with respect to the substrate, and a single cell was vertically pulled up. The measurement techniques will be used to compare and discuss the difference beten the shear force and adhesion force.
['Shigetaka Hashimoto', 'Futoshi Iwata']
I am writing a research paper on a idea Measurement of shear force and adhesion force of a single adhesion cell using atomic force microscopy with a self-sensitive cantilever
[{"from": "human", "value": "I am writing a research paper on a idea Measurement of shear force and adhesion force of a single adhesion cell using atomic force microscopy with a self-sensitive cantilever"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: ,  investigated adhesion force of a single cell on an extracellular matrix (ECM) by measuring shear force and detachment energy. As the ECM, fibronectin (FN) was employed. To measure the shear force,  have a developed direct measurement system based on atomic force microscopy (AFM). An AFM microcantilever was mounted vertically with respect to a substrate, and a single cell on the substrate was laterally pushed and dragged by the cantilever until the cell was detached from the substrate. From the deflection of the cantilever during the cell detachment, the shear force was measured. Furthermore, to measure cell adhesion force, the cantilever was mounted horizontally with respect to the substrate, and a single cell was vertically pulled up. The measurement techniques will be used to compare and discuss the difference beten the shear force and adhesion force."}]