Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The human brainstem is a complex structure with several small nuclei and neural pathways of interest in the pathophysiology of central nervous system (CNS) disorders. In common with other monoaminergic systems, serotoninergic neurons originate from a group of nuclei located in the brainstem. The present study was designed to validate a user-independent approach for a detailed in vivo quantification of serotonin transporter (5-HTT) availability in the human brainstem using a template-based approach that consisted of three steps. First, 3 T-MR images and parametric binding potential (BPND) [11C]MADAM images of ten healthy subjects re used to generate a PET template of 5-HTT availability. In the second step, volumes of interest (VOIs) for different brainstem nuclei re obtained using a method in which VOIs are initially delineated on MRI images using anatomical landmarks and then are finally tailored on the distribution of 5-HTT binding using a thresholding approach applied to the 5-HTT template. In the final step, the VOIs re transformed and applied individually to BPND images of 16 healthy subjects (14 M/2F, 20–64 years). The in vivo distribution of BPND values obtained with the template-based method re in good agreement with an individual-based approach taken as gold standard. Results re also in agreement with 5-HTT quantification using in vitro binding data obtained with autoradiography (ARG) studies using [3H]MADAM. The proposed template-based method can be applied to PET data acquired in several CNS disorders in which serotonin neurons in the brainstem might be affected.
['Patrik Fazio', 'Martin Schain', 'Katarina Varnäs', 'Christer Halldin', 'Lars Farde', 'Andrea Varrone']
I am writing a research paper on a idea Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data.
[{"from": "human", "value": "I am writing a research paper on a idea Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data."}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The human brainstem is a complex structure with several small nuclei and neural pathways of interest in the pathophysiology of central nervous system (CNS) disorders. In common with other monoaminergic systems, serotoninergic neurons originate from a group of nuclei located in the brainstem. The present study was designed to validate a user-independent approach for a detailed in vivo quantification of serotonin transporter (5-HTT) availability in the human brainstem using a template-based approach that consisted of three steps. First, 3\u00a0T-MR images and parametric binding potential (BPND) [11C]MADAM images of ten healthy subjects re used to generate a PET template of 5-HTT availability. In the second step, volumes of interest (VOIs) for different brainstem nuclei re obtained using a method in which VOIs are initially delineated on MRI images using anatomical landmarks and then are finally tailored on the distribution of 5-HTT binding using a thresholding approach applied to the 5-HTT template. In the final step, the VOIs re transformed and applied individually to BPND images of 16 healthy subjects (14\u00a0M/2F, 20\u201364\u00a0years). The in vivo distribution of BPND values obtained with the template-based method re in good agreement with an individual-based approach taken as gold standard. Results re also in agreement with 5-HTT quantification using in vitro binding data obtained with autoradiography (ARG) studies using [3H]MADAM. The proposed template-based method can be applied to PET data acquired in several CNS disorders in which serotonin neurons in the brainstem might be affected."}]