Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: After several decades of study, the dynamics of synaptic plasticity in neurons still remains somewhat a mystery. By conducting a series of simulations on a simulated version of an in-vivo experiment on the rat dentate gyrus granule cell, using the Izhikevich spiking neuron model,  compare and contrast several potential synaptic plasticity rules' applicability to the same experiment. Our simulations reveal that spike timing dependent plasticity (STDP), a more recent theory of synaptic plasticity, is insufficient to replicate the heterosynaptic LTD shown in the experiment without including aspects of the significantly older Bienenstock-Cooper-Munro (BCM) theory. The STDP rule modified by including the history of postsynaptic spiking seems most likely to be an accurate candidate for reproducing the heterosynaptic plasticity dynamics.
['Nicholas Hananeia', 'Lubica Benuskova']
I am writing a research paper on a idea Computational simulation of dentate gyrus granule cell-The role of metaplasticity
[{"from": "human", "value": "I am writing a research paper on a idea Computational simulation of dentate gyrus granule cell-The role of metaplasticity"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: After several decades of study, the dynamics of synaptic plasticity in neurons still remains somewhat a mystery. By conducting a series of simulations on a simulated version of an in-vivo experiment on the rat dentate gyrus granule cell, using the Izhikevich spiking neuron model,  compare and contrast several potential synaptic plasticity rules' applicability to the same experiment. Our simulations reveal that spike timing dependent plasticity (STDP), a more recent theory of synaptic plasticity, is insufficient to replicate the heterosynaptic LTD shown in the experiment without including aspects of the significantly older Bienenstock-Cooper-Munro (BCM) theory. The STDP rule modified by including the history of postsynaptic spiking seems most likely to be an accurate candidate for reproducing the heterosynaptic plasticity dynamics."}]