Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Protein–ligand interaction analysis is an important step of drug design and protein engineering in order to predict the binding affinity and selectivity beten ligands to the target proteins. To date, there are more than 100 000 structures available in the Protein Data Bank (PDB), of which ∼30% are protein–ligand (MW below 1000 Da) complexes.  have developed the integrative b server MANORAA (Mapping Analogous Nuclei Onto Residue And Affinity) with the aim of providing a user-friendly b interface to assist structural study and design of protein–ligand interactions. In brief, the server allows the users to input the chemical fragments and present all the unique molecular interactions to the target proteins with available three-dimensional structures in the PDB. The users can also link the ligands of interest to assess possible off-target proteins, human variants and pathway information using our all-in-one integrated tools. Taken together,  envisage that the server will facilitate and improve the study of protein–ligand interactions by allowing observation and comparison of ligand interactions with multiple proteins at the same time. (http://manoraa.org).
['Duangrudee Tanramluk', 'Lalita Narupiyakul', 'Ruj Akavipat', 'Sungsam Gong', 'Varodom Charoensawan']
I am writing a research paper on a idea MANORAA (Mapping Analogous Nuclei Onto Residue And Affinity) for identifying protein-ligand fragment interaction, pathways and SNPs.
[{"from": "human", "value": "I am writing a research paper on a idea MANORAA (Mapping Analogous Nuclei Onto Residue And Affinity) for identifying protein-ligand fragment interaction, pathways and SNPs."}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Protein\u2013ligand interaction analysis is an important step of drug design and protein engineering in order to predict the binding affinity and selectivity beten ligands to the target proteins. To date, there are more than 100 000 structures available in the Protein Data Bank (PDB), of which \u223c30% are protein\u2013ligand (MW below 1000 Da) complexes.  have developed the integrative b server MANORAA (Mapping Analogous Nuclei Onto Residue And Affinity) with the aim of providing a user-friendly b interface to assist structural study and design of protein\u2013ligand interactions. In brief, the server allows the users to input the chemical fragments and present all the unique molecular interactions to the target proteins with available three-dimensional structures in the PDB. The users can also link the ligands of interest to assess possible off-target proteins, human variants and pathway information using our all-in-one integrated tools. Taken together,  envisage that the server will facilitate and improve the study of protein\u2013ligand interactions by allowing observation and comparison of ligand interactions with multiple proteins at the same time. (http://manoraa.org)."}]