Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: There has been considerable interest in developing computational techniques for inferring genetic regulatory networks from whole-genome expression profiles. When expression time series data sets are available, dynamic models can, in principle, be used to infer correlative relationships beten gene expression levels, which may be causal. Hover, because of the range of detectable expression levels and the current quality of the data, the predictive nature of such inferred, quantitative models is questionable. Network models derived from simple rate laws offer an intermediate level analysis, going beyond simple statistical analysis, but falling short of a fully quantitative description. This work shows how such network models can be constructed and describes the global properties of the networks derived from such a model. These global properties are statistically robust and provide insights into the design of the underlying network. Results: Several whole-genome expression time series data sets from yeast microarray experiments re analyzed using a Markov-modeling method (Dey and Galas, Func. Integr. Genomics, 1, 269‐278, 2001) to infer an approximation to the underlying genetic network.  found that the global statistical properties of all the resulting networks are similar. The overall structure of these biological networks is distinctly different from that of other recently studied networks such as the Internet or social networks. These biological networks show hierarchical, hub-like structures that have some properties similar to a class of graphs known as small world graphs. Small world networks exhibit local cliquishness while exhibiting strong global connectivity. In addition to the small world properties, the biological networks show a por law or scale free distribution of connectivities. An inverse por law, N(k) ∼ k −3/2 , for the number of vertices (genes) with k connections was observed for three different data sets from yeast.  propose network growth models based on gene duplication events. Simulations of these models yield networks with the same combination of global graphical
['Ashish Bhan', 'David J. Galas', 'T. Gregory Dewey']
I am writing a research paper on a idea A duplication growth model of gene expression networks.
[{"from": "human", "value": "I am writing a research paper on a idea A duplication growth model of gene expression networks."}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: There has been considerable interest in developing computational techniques for inferring genetic regulatory networks from whole-genome expression profiles. When expression time series data sets are available, dynamic models can, in principle, be used to infer correlative relationships beten gene expression levels, which may be causal. Hover, because of the range of detectable expression levels and the current quality of the data, the predictive nature of such inferred, quantitative models is questionable. Network models derived from simple rate laws offer an intermediate level analysis, going beyond simple statistical analysis, but falling short of a fully quantitative description. This work shows how such network models can be constructed and describes the global properties of the networks derived from such a model. These global properties are statistically robust and provide insights into the design of the underlying network. Results: Several whole-genome expression time series data sets from yeast microarray experiments re analyzed using a Markov-modeling method (Dey and Galas, Func. Integr. Genomics, 1, 269\u2010278, 2001) to infer an approximation to the underlying genetic network.  found that the global statistical properties of all the resulting networks are similar. The overall structure of these biological networks is distinctly different from that of other recently studied networks such as the Internet or social networks. These biological networks show hierarchical, hub-like structures that have some properties similar to a class of graphs known as small world graphs. Small world networks exhibit local cliquishness while exhibiting strong global connectivity. In addition to the small world properties, the biological networks show a por law or scale free distribution of connectivities. An inverse por law, N(k) \u223c k \u22123/2 , for the number of vertices (genes) with k connections was observed for three different data sets from yeast.  propose network growth models based on gene duplication events. Simulations of these models yield networks with the same combination of global graphical"}]