Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The internal transcribed spacer 2 (ITS2) is a widely used phylogenetic marker. In the past, it has mainly been used for species level classifications. Nowadays, a wider applicability becomes apparent. Here, the conserved structure of the RNA molecule plays a vital role.  have developed the ITS2 Database (http://its2.bioapps .biozentrum.uni-wuerzburg.de) which holds information about sequence, structure and taxonomic classification of all ITS2 in GenBank. In the new version,  use Hidden Markov models (HMMs) for the identification and delineation of the ITS2 resulting in a major redesign of the annotation pipeline. This allod the identification of more than 160 000 correct full length and more than 50 000 partial structures. In the b interface, these can now be searched with a modified BLAST considering both sequence and structure, enabling rapid taxon sampling. Novel sequences can be annotated using the HMM based approach and modelled according to multiple template structures. Sequences can be searched for known and newly identified motifs. Together, the database and the b server build an exhaustive resource for ITS2 based phylogenetic analyses.
['Christian Koetschan', 'Frank Förster', 'Alexander Keller', 'Tina Schleicher', 'Benjamin Ruderisch', 'Roland F. Schwarz', 'Tobias Müller', 'Matthias Wolf', 'Jörg Schultz']
I am writing a research paper on a idea The ITS2 Database III—sequences and structures for phylogeny
[{"from": "human", "value": "I am writing a research paper on a idea The ITS2 Database III\u2014sequences and structures for phylogeny"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The internal transcribed spacer 2 (ITS2) is a widely used phylogenetic marker. In the past, it has mainly been used for species level classifications. Nowadays, a wider applicability becomes apparent. Here, the conserved structure of the RNA molecule plays a vital role.  have developed the ITS2 Database (http://its2.bioapps .biozentrum.uni-wuerzburg.de) which holds information about sequence, structure and taxonomic classification of all ITS2 in GenBank. In the new version,  use Hidden Markov models (HMMs) for the identification and delineation of the ITS2 resulting in a major redesign of the annotation pipeline. This allod the identification of more than 160 000 correct full length and more than 50 000 partial structures. In the b interface, these can now be searched with a modified BLAST considering both sequence and structure, enabling rapid taxon sampling. Novel sequences can be annotated using the HMM based approach and modelled according to multiple template structures. Sequences can be searched for known and newly identified motifs. Together, the database and the b server build an exhaustive resource for ITS2 based phylogenetic analyses."}]