Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Telomere maintenance is a universal cancer hallmark, and small molecules that disrupt telomere maintenance generally have anticancer properties. Since the vast majority of cancer cells utilize telomerase activity for telomere maintenance, the enzyme has been considered as an anticancer drug target. Recently, rational design of telomerase inhibitors was made possible by the determination of high resolution structures of the catalytic telomerase subunit from a beetle and subsequent molecular modeling of the human telomerase complex. A hybrid strategy including docking, pharmacophore-based virtual screening, and molecular dynamics simulations (MDS) re used to identify new human telomerase inhibitors. Docking methodology was applied to investigate the ssDNA telomeric sequence and two ll-known human telomerase inhibitors’ (BIBR1532 and MST-312) modes of interactions with hTERT TEN domain. Subsequently molecular dynamic simulations re performed to monitor and compare hTERT TEN domain, TEN−ssDNA, TEN–BIBR1...
['Faezeh Shirgahi Talari', 'Kowsar Bagherzadeh', 'Sahand Golestanian', 'Michael B. Jarstfer', 'Massoud Amanlou']
I am writing a research paper on a idea Potent Human Telomerase Inhibitors: Molecular Dynamic Simulations, Multiple Pharmacophore-Based Virtual Screening, and Biochemical Assays
[{"from": "human", "value": "I am writing a research paper on a idea Potent Human Telomerase Inhibitors: Molecular Dynamic Simulations, Multiple Pharmacophore-Based Virtual Screening, and Biochemical Assays"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Telomere maintenance is a universal cancer hallmark, and small molecules that disrupt telomere maintenance generally have anticancer properties. Since the vast majority of cancer cells utilize telomerase activity for telomere maintenance, the enzyme has been considered as an anticancer drug target. Recently, rational design of telomerase inhibitors was made possible by the determination of high resolution structures of the catalytic telomerase subunit from a beetle and subsequent molecular modeling of the human telomerase complex. A hybrid strategy including docking, pharmacophore-based virtual screening, and molecular dynamics simulations (MDS) re used to identify new human telomerase inhibitors. Docking methodology was applied to investigate the ssDNA telomeric sequence and two ll-known human telomerase inhibitors\u2019 (BIBR1532 and MST-312) modes of interactions with hTERT TEN domain. Subsequently molecular dynamic simulations re performed to monitor and compare hTERT TEN domain, TEN\u2212ssDNA, TEN\u2013BIBR1..."}]