Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The abnormal transcriptional regulation of non-coding RNAs (ncRNAs) and protein-coding genes (PCGs) is contributed to various biological processes and linked with human diseases, but the underlying mechanisms remain elusive. In this study,  developed ChIPBase v2.0 (http://rna.sysu.edu.cn/chipbase/) to explore the transcriptional regulatory networks of ncRNAs and PCGs. ChIPBase v2.0 has been expanded with ∼10 200 curated ChIP-seq datasets, which represent about 20 times expansion when comparing to the previous released version.  identified thousands of binding motif matrices and their binding sites from ChIP-seq data of DNA-binding proteins and predicted millions of transcriptional regulatory relationships beten transcription factors (TFs) and genes.  constructed ‘Regulator’ module to predict hundreds of TFs and histone modifications that re involved in or affected transcription of ncRNAs and PCGs. Moreover,  built a b-based tool, Co-Expression, to explore the co-expression patterns beten DNA-binding proteins and various types of genes by integrating the gene expression profiles of ∼10 000 tumor samples and ∼9100 normal tissues and cell lines. ChIPBase also provides a ChIP-Function tool and a genome browser to predict functions of diverse genes and visualize various ChIP-seq data. This study will greatly expand our understanding of the transcriptional regulations of ncRNAs and PCGs.
['Ke-Ren Zhou', 'Shun Liu', 'Wen-Ju Sun', 'Ling-Ling Zheng', 'Hui Zhou', 'Jian-Hua Yang', 'Liang-Hu Qu']
I am writing a research paper on a idea ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data
[{"from": "human", "value": "I am writing a research paper on a idea ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The abnormal transcriptional regulation of non-coding RNAs (ncRNAs) and protein-coding genes (PCGs) is contributed to various biological processes and linked with human diseases, but the underlying mechanisms remain elusive. In this study,  developed ChIPBase v2.0 (http://rna.sysu.edu.cn/chipbase/) to explore the transcriptional regulatory networks of ncRNAs and PCGs. ChIPBase v2.0 has been expanded with \u223c10 200 curated ChIP-seq datasets, which represent about 20 times expansion when comparing to the previous released version.  identified thousands of binding motif matrices and their binding sites from ChIP-seq data of DNA-binding proteins and predicted millions of transcriptional regulatory relationships beten transcription factors (TFs) and genes.  constructed \u2018Regulator\u2019 module to predict hundreds of TFs and histone modifications that re involved in or affected transcription of ncRNAs and PCGs. Moreover,  built a b-based tool, Co-Expression, to explore the co-expression patterns beten DNA-binding proteins and various types of genes by integrating the gene expression profiles of \u223c10 000 tumor samples and \u223c9100 normal tissues and cell lines. ChIPBase also provides a ChIP-Function tool and a genome browser to predict functions of diverse genes and visualize various ChIP-seq data. This study will greatly expand our understanding of the transcriptional regulations of ncRNAs and PCGs."}]