Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#RNA-sequencing (RNA-Seq) has become a popular tool for transcriptome profiling in mammals. Hover, accurate estimation of allele-specific expression (ASE) based on alignments of reads to the reference genome is challenging, because it contains only one allele on a mosaic haploid genome. Even with the information of diploid genome sequences, precise alignment of reads to the correct allele is difficult because of the high-similarity beten the corresponding allele sequences.
['Naoki Nariai', 'K. M. Kojima', 'Takahiro Mimori', 'Yosuke Kawai', 'Masao Nagasaki']
I am writing a research paper on a idea A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes
[{"from": "human", "value": "I am writing a research paper on a idea A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#RNA-sequencing (RNA-Seq) has become a popular tool for transcriptome profiling in mammals. Hover, accurate estimation of allele-specific expression (ASE) based on alignments of reads to the reference genome is challenging, because it contains only one allele on a mosaic haploid genome. Even with the information of diploid genome sequences, precise alignment of reads to the correct allele is difficult because of the high-similarity beten the corresponding allele sequences."}]