Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: ,  devote to detect those deletions, insertions and inversions, in total of three kinds of structural variations in Heidou12 genome relative to Williams82 genome.  propose two sequencing characteristic based probability models, which use the paired-end reads of Hedou12 and their mapping distribution on Williams82 to evaluate on with what probability a potential structural variant can happen. To reduce the conflicts of those potential structural variants,  propose a set cover problem model to formalize on finding structural variants covering all those reads causing potential structural variants with as high as possible probabilities, and use a primal-dual based algorithm to solve it. The efficiency and feasibility of our algorithm are verified by comparing with DELLY(version0.5.5) and LUMPY (27.12.2014).
['Huiqiang Jia', 'Haicho Wei', 'Daming Zhu', 'Jingjing Ma', 'Yang H', 'Ruizhi Wang', 'Xianzhong Feng']
I am writing a research paper on a idea Mining structural variants of Heduo12 using paired-end reads
[{"from": "human", "value": "I am writing a research paper on a idea Mining structural variants of Heduo12 using paired-end reads"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: ,  devote to detect those deletions, insertions and inversions, in total of three kinds of structural variations in Heidou12 genome relative to Williams82 genome.  propose two sequencing characteristic based probability models, which use the paired-end reads of Hedou12 and their mapping distribution on Williams82 to evaluate on with what probability a potential structural variant can happen. To reduce the conflicts of those potential structural variants,  propose a set cover problem model to formalize on finding structural variants covering all those reads causing potential structural variants with as high as possible probabilities, and use a primal-dual based algorithm to solve it. The efficiency and feasibility of our algorithm are verified by comparing with DELLY(version0.5.5) and LUMPY (27.12.2014)."}]