Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main ORF by interfering with translational reinitiation at the main start codon. uORFs also occur by chance in the genome, in which case they do not have a regulatory role. Since the sequence determinants for functional uORFs are not understood, it is difficult to discriminate functional from spurious uORFs by sequence analysis.
['Marija Cvijovic', 'Daniel Dalevi', 'Elizabeth Bilsland', 'Graham J. L. Kemp', 'Per Sunnerhagen']
I am writing a research paper on a idea Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation
[{"from": "human", "value": "I am writing a research paper on a idea Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main ORF by interfering with translational reinitiation at the main start codon. uORFs also occur by chance in the genome, in which case they do not have a regulatory role. Since the sequence determinants for functional uORFs are not understood, it is difficult to discriminate functional from spurious uORFs by sequence analysis."}]