Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Cryo-electron microscopy (Cryo-EM) has become central to the study of large-scale molecular interactions and has produced three-dimensional (3D) density maps at various resolutions. Secondary structure element (SSE) identification from volumetric protein density maps is critical for de novo backbone structure derivation in cryo-EM. Multiple methods have been developed to detect helix and β-sheet from density maps at medium resolutions (~5-10A). β-barrel as a special β-sheet structure has been found in many proteins. Hover, currently there are no methods aimed to automatically and accurately extract the β-barrel as a complete chunk of density from cryo-EM map of β-barrel protein.  present an effective approach, BarrelMiner, to automatically extract the β-barrel region from cryo-EM density maps based on the conspicuous cylindrical shape of β-barrel. BarrelMiner has been tested using ten simulated density maps at 10A resolution and seven experimental cryo-EM maps beten 5.5A and 8.25A resolution. The result suggests that BarrelMiner can be used for the detection of β-barrel from medium resolution cryo-EM density maps of β-barrel proteins.
['Dong Si']
I am writing a research paper on a idea Automatic Detection of Beta-barrel from Medium Resolution Cryo-EM Density Maps
[{"from": "human", "value": "I am writing a research paper on a idea Automatic Detection of Beta-barrel from Medium Resolution Cryo-EM Density Maps"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Cryo-electron microscopy (Cryo-EM) has become central to the study of large-scale molecular interactions and has produced three-dimensional (3D) density maps at various resolutions. Secondary structure element (SSE) identification from volumetric protein density maps is critical for de novo backbone structure derivation in cryo-EM. Multiple methods have been developed to detect helix and \u03b2-sheet from density maps at medium resolutions (~5-10A). \u03b2-barrel as a special \u03b2-sheet structure has been found in many proteins. Hover, currently there are no methods aimed to automatically and accurately extract the \u03b2-barrel as a complete chunk of density from cryo-EM map of \u03b2-barrel protein.  present an effective approach, BarrelMiner, to automatically extract the \u03b2-barrel region from cryo-EM density maps based on the conspicuous cylindrical shape of \u03b2-barrel. BarrelMiner has been tested using ten simulated density maps at 10A resolution and seven experimental cryo-EM maps beten 5.5A and 8.25A resolution. The result suggests that BarrelMiner can be used for the detection of \u03b2-barrel from medium resolution cryo-EM density maps of \u03b2-barrel proteins."}]