Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Facing substantial obstacles to developing new therapies for rare diseases, some sponsors are looking to ‘repurpose’ drugs already approved for other conditions and use those therapies to treat rare diseases. In an effort to facilitate such repurposing and speed the delivery of new therapies to people who need them,  have established a new resource, the Rare Disease Repurposing Database (RDRD). The advantages of repurposed compounds include their demonstrated efficacy (in some clinical contexts), their observed toxicity profiles and their clearly described manufacturing controls. To create the RDRD,  matched the US Food and Drug Administration (FDA) orphan designation database to FDA drug and biological product approval lists. The RDRD lists 236 products that have received orphan status designationcthat is, re found to be ‘promising’ for the treatment of a rare diseasecand though not yet approved for marketing for that rare disease, they are already approved for marketing to treat some other disease or condition. The RDRD contains three tables: Orphan-designated products with at least one marketing approval for a common disease indication (N ¼109); orphan-designated products with at least one marketing approval for a rare disease indication (N ¼ 76); and orphan-designated products with marketing approvals for both common and rare disease indications (N ¼ 51). While the data included in the database is a re-configuration/ cross-indexing of information already released by the FDA, it offers sponsors a new tool for finding special opportunities to develop niche therapies for rare disease patients.
['Kui Xu', 'Timothy R. Coté']
I am writing a research paper on a idea Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases
[{"from": "human", "value": "I am writing a research paper on a idea Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Facing substantial obstacles to developing new therapies for rare diseases, some sponsors are looking to \u2018repurpose\u2019 drugs already approved for other conditions and use those therapies to treat rare diseases. In an effort to facilitate such repurposing and speed the delivery of new therapies to people who need them,  have established a new resource, the Rare Disease Repurposing Database (RDRD). The advantages of repurposed compounds include their demonstrated efficacy (in some clinical contexts), their observed toxicity profiles and their clearly described manufacturing controls. To create the RDRD,  matched the US Food and Drug Administration (FDA) orphan designation database to FDA drug and biological product approval lists. The RDRD lists 236 products that have received orphan status designationcthat is, re found to be \u2018promising\u2019 for the treatment of a rare diseasecand though not yet approved for marketing for that rare disease, they are already approved for marketing to treat some other disease or condition. The RDRD contains three tables: Orphan-designated products with at least one marketing approval for a common disease indication (N \u00bc109); orphan-designated products with at least one marketing approval for a rare disease indication (N \u00bc 76); and orphan-designated products with marketing approvals for both common and rare disease indications (N \u00bc 51). While the data included in the database is a re-configuration/ cross-indexing of information already released by the FDA, it offers sponsors a new tool for finding special opportunities to develop niche therapies for rare disease patients."}]