Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Alternative polyadenylation (APA) is a widespread mechanism that contributes to the sophisticated dynamics of gene regulation. Approximately 50% of all protein-coding human genes harbor multiple polyadenylation (PA) sites; their selective and combinatorial use gives rise to transcript variants with differing length of their 3 0 untranslated region (3 0 UTR). Shortened variants escape UTR-mediated regulation by microRNAs (miRNAs), especially in cancer, where global 3 0 UTR shortening accelerates disease progression, dedifferentiation and proliferation. Here  present APADB, a database of vertebrate PA sites determined by 3 0 end sequencing, using massive analysis of complementary DNA ends. APADB provides (A)PA sites for coding and non-coding transcripts of human, mouse and chicken genes. For human and mouse, several tissue types, including different cancer specimens, are available. APADB records the loss of predicted miRNA binding sites and visualizes next-generation sequencing reads that support each PA site in a genome browser. The database tables can either be browsed according to organism and tissue or alternatively searched for a gene of interest. APADB is the largest database
['Sören Müller', 'Lukas Rycak', 'Fabian Afonso-Grunz', 'Peter Winter', 'Adam M. Zawada', 'Ewa Damrath', 'Jessica Scheider', 'J Schmäh', 'Ina Koch', 'Günter Kahl', 'Björn Rotter']
I am writing a research paper on a idea APADB: a database for alternative polyadenylation and microRNA regulation events
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