Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The gut microbiome has been shown to regulate the development and functions of the enteric and central nervous systems. Its involvement in the regulation of behavior has attracted particular attention because of its potential translational importance in clinical disorders, hover little is known about the pathways involved.  previously have demonstrated that administration of Lactobacillus rhamnosus (JB-1) to healthy male BALB/c mice, promotes consistent changes in GABA-A and -B receptor sub-types in specific brain regions, accompanied by reductions in anxiety and depression-related behaviors. In the present study, using magnetic resonance spectroscopy (MRS),  quantitatively assessed two clinically validated biomarkers of brain activity and function, glutamate + glutamine (Glx) and total N-acetyl aspartate + N-acetyl aspartyl glutamic acid (tNAA), as ll as GABA, the chief brain inhibitory neurotransmitter. Mice received 1 × 109 cfu of JB-1 per day for 4 eks and re subjected to MRS ekly and again 4 eks after cessation of treatment to ascertain temporal changes in these neurometabolites. Baseline concentrations for Glx, tNAA and GABA re equal to 10.4 ± 0.3 mM, 8.7 ± 0.1 mM, and 1.2 ± 0.1 mM, respectively. Delayed increases re first seen for Glx (~ 10%) and NAA (~ 37%) at 2 eks which persisted only to the end of treatment. Hover, Glx was still elevated 4 eks after treatment had ceased. Significantly elevated GABA (~ 25%) was only seen at 4 eks. These results suggest specific metabolic pathways in our pursuit of mechanisms of action of psychoactive bacteria. They also offer through application of standard clinical neurodiagnostic techniques, translational opportunities to assess biomarkers accompanying behavioral changes induced by alterations in the gut microbiome.
['Rafal Janik', 'Lynsie A.M. Thomason', 'Andrew M. Stanisz', 'Paul Forsythe', 'John Bienenstock', 'Greg J. Stanisz']
I am writing a research paper on a idea Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate
[{"from": "human", "value": "I am writing a research paper on a idea Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The gut microbiome has been shown to regulate the development and functions of the enteric and central nervous systems. Its involvement in the regulation of behavior has attracted particular attention because of its potential translational importance in clinical disorders, hover little is known about the pathways involved.  previously have demonstrated that administration of Lactobacillus rhamnosus (JB-1) to healthy male BALB/c mice, promotes consistent changes in GABA-A and -B receptor sub-types in specific brain regions, accompanied by reductions in anxiety and depression-related behaviors. In the present study, using magnetic resonance spectroscopy (MRS),  quantitatively assessed two clinically validated biomarkers of brain activity and function, glutamate\u00a0+\u00a0glutamine (Glx) and total N-acetyl aspartate\u00a0+\u00a0N-acetyl aspartyl glutamic acid (tNAA), as ll as GABA, the chief brain inhibitory neurotransmitter. Mice received 1\u00a0\u00d7\u00a0109 cfu of JB-1 per day for 4\u00a0eks and re subjected to MRS ekly and again 4\u00a0eks after cessation of treatment to ascertain temporal changes in these neurometabolites. Baseline concentrations for Glx, tNAA and GABA re equal to 10.4\u00a0\u00b1\u00a00.3\u00a0mM, 8.7\u00a0\u00b1\u00a00.1\u00a0mM, and 1.2\u00a0\u00b1\u00a00.1\u00a0mM, respectively. Delayed increases re first seen for Glx (~\u00a010%) and NAA (~\u00a037%) at 2\u00a0eks which persisted only to the end of treatment. Hover, Glx was still elevated 4\u00a0eks after treatment had ceased. Significantly elevated GABA (~\u00a025%) was only seen at 4\u00a0eks. These results suggest specific metabolic pathways in our pursuit of mechanisms of action of psychoactive bacteria. They also offer through application of standard clinical neurodiagnostic techniques, translational opportunities to assess biomarkers accompanying behavioral changes induced by alterations in the gut microbiome."}]