Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#Mitochondria play a critical role in the cell and have DNA independent of the nuclear genome. There is much evidence that mitochondrial DNA (mtDNA) variation plays a role in human health and disease, hover, this area of investigation has lagged behind research into the role of nuclear genetic variation on complex traits and phenotypic outcomes. Phenome-wide association studies (PheWAS) investigate the association beten a wide range of traits and genetic variation. To date, this approach has not been used to investigate the relationship beten mtDNA variants and phenotypic variation. Herein,  describe the development of a PheWAS framework for mtDNA variants (mt-PheWAS). Using the Metabochip custom genotyping array, nuclear and mitochondrial DNA variants re genotyped in 11,519 African Americans from the Vanderbilt University biorepository, BioVU.  employed both polygenic modeling and association testing with mitochondrial single nucleotide polymorphisms (mtSNPs) to explore the relationship beten mtDNA variants and a group of eight cardiovascular-related traits obtained from de-identified electronic medical records within BioVU.
['Sabrina L. Mitchell', 'Jacob B Hall', 'Robert Goodloe', 'Jonathan Boston', 'Eric Farber-Eger', 'Sarah A. Pendergrass', 'William S. Bush', 'Dana C. Crawford']
I am writing a research paper on a idea Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studies
[{"from": "human", "value": "I am writing a research paper on a idea Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studies"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Background#R##N#Mitochondria play a critical role in the cell and have DNA independent of the nuclear genome. There is much evidence that mitochondrial DNA (mtDNA) variation plays a role in human health and disease, hover, this area of investigation has lagged behind research into the role of nuclear genetic variation on complex traits and phenotypic outcomes. Phenome-wide association studies (PheWAS) investigate the association beten a wide range of traits and genetic variation. To date, this approach has not been used to investigate the relationship beten mtDNA variants and phenotypic variation. Herein,  describe the development of a PheWAS framework for mtDNA variants (mt-PheWAS). Using the Metabochip custom genotyping array, nuclear and mitochondrial DNA variants re genotyped in 11,519 African Americans from the Vanderbilt University biorepository, BioVU.  employed both polygenic modeling and association testing with mitochondrial single nucleotide polymorphisms (mtSNPs) to explore the relationship beten mtDNA variants and a group of eight cardiovascular-related traits obtained from de-identified electronic medical records within BioVU."}]