Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem—particularly for phase coherence in oscillating systems.#R##N##R##N#Results: The present article presents a novel strategy for construction of large-scale simulation programs of heterogeneous biological entities. The strategy is designed to be tractable, to handle heterogeneity and to handle computational cost issues simultaneously, primarily by writing a generator of the ‘model to be simulated’.  apply the strategy to model glycolytic oscillations among thousands of yeast cells coupled through the extracellular medium. The usefulness is illustrated through (i) benchmarking, showing an almost linear relationship beten model size and run time, and (ii) analysis of the resulting simulations, showing that contrary to the experimental situation, synchronous oscillations are surprisingly hard to achieve, underpinning the need for tools to study heterogeneity. Thus,  present an efficient strategy to model the biological heterogeneity, neglected by ordinary mean-field models. This tool is ll posed to facilitate the elucidation of the physiologically vital problem of synchronization.#R##N##R##N#Availability: The complete python code is available as Supplementary Information.#R##N##R##N#Contact:bjornhald@gmail.com or pgs@kiku.dk#R##N##R##N#Supplementary information: Supplementary data are available at Bioinformatics online.
['Bjørn Olav Hald', 'Morten Garkier Hendriksen', 'Preben Graae Sørensen']
I am writing a research paper on a idea Programming strategy for efficient modeling of dynamics in a population of heterogeneous cells
[{"from": "human", "value": "I am writing a research paper on a idea Programming strategy for efficient modeling of dynamics in a population of heterogeneous cells"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: Heterogeneity is a ubiquitous property of biological systems. Even in a genetically identical population of a single cell type, cell-to-cell differences are observed. Although the functional behavior of a given population is generally robust, the consequences of heterogeneity are fairly unpredictable. In heterogeneous populations, synchronization of events becomes a cardinal problem\u2014particularly for phase coherence in oscillating systems.#R##N##R##N#Results: The present article presents a novel strategy for construction of large-scale simulation programs of heterogeneous biological entities. The strategy is designed to be tractable, to handle heterogeneity and to handle computational cost issues simultaneously, primarily by writing a generator of the \u2018model to be simulated\u2019.  apply the strategy to model glycolytic oscillations among thousands of yeast cells coupled through the extracellular medium. The usefulness is illustrated through (i) benchmarking, showing an almost linear relationship beten model size and run time, and (ii) analysis of the resulting simulations, showing that contrary to the experimental situation, synchronous oscillations are surprisingly hard to achieve, underpinning the need for tools to study heterogeneity. Thus,  present an efficient strategy to model the biological heterogeneity, neglected by ordinary mean-field models. This tool is ll posed to facilitate the elucidation of the physiologically vital problem of synchronization.#R##N##R##N#Availability: The complete python code is available as Supplementary Information.#R##N##R##N#Contact:bjornhald@gmail.com or pgs@kiku.dk#R##N##R##N#Supplementary information: Supplementary data are available at Bioinformatics online."}]