Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Retinal vessel calibre has been found to be an important biomarker of several retinal diseases, including diabetic retinopathy (DR). Quantifying the retinal vessel calibres is an important step for estimating the central retinal artery and vein equivalents. In this study, an alternative method to the already established branching coefficient (BC) is proposed for summarising the vessel calibres in retinal junctions. This new method combines the mean diameter ratio with an alternative to Murray's cube law exponent, derived by the fractal dimension,experimentally, and the branch exponent of cerebral vessels, as has been suggested in previous studies with blood flow modelling. For the above calculations, retinal images from healthy, diabetic and DR subjects re used. In addition, the above method was compared with the BC and was also applied to the evaluation of arteriovenous ratio as a biomarker of progression from diabetes to DR in four consecutive years, i.e. three/two/one years before the onset of DR and the first year of DR. Moreover, the retinal arteries and veins around the optic nerve head re also evaluated. The new approach quantifies the vessels more accurately. The decrease in terms of the mean absolute percentage error was beten 0.24% and 0.49%, extending at the same time the quantification beyond healthy subjects. HighlightsA novel and improved method for quantifying the retinal vessel calibres was presented.Junction exponents re experimentally derived for different groups, based on the fractal dimension and the branch exponent.New formulas re introduced for summarising the vessel calibres in healthy, diabetic and diabetic retinopathy eyes.The improvement in terms of the mean absolute percentage error ranged from 0.24% to 0.49%.
['Georgios Leontidis', 'Bashir Al-Diri', 'Andrew Hunter']
I am writing a research paper on a idea Summarising the retinal vascular calibres in healthy, diabetic and diabetic retinopathy eyes
[{"from": "human", "value": "I am writing a research paper on a idea Summarising the retinal vascular calibres in healthy, diabetic and diabetic retinopathy eyes"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Retinal vessel calibre has been found to be an important biomarker of several retinal diseases, including diabetic retinopathy (DR). Quantifying the retinal vessel calibres is an important step for estimating the central retinal artery and vein equivalents. In this study, an alternative method to the already established branching coefficient (BC) is proposed for summarising the vessel calibres in retinal junctions. This new method combines the mean diameter ratio with an alternative to Murray's cube law exponent, derived by the fractal dimension,experimentally, and the branch exponent of cerebral vessels, as has been suggested in previous studies with blood flow modelling. For the above calculations, retinal images from healthy, diabetic and DR subjects re used. In addition, the above method was compared with the BC and was also applied to the evaluation of arteriovenous ratio as a biomarker of progression from diabetes to DR in four consecutive years, i.e. three/two/one years before the onset of DR and the first year of DR. Moreover, the retinal arteries and veins around the optic nerve head re also evaluated. The new approach quantifies the vessels more accurately. The decrease in terms of the mean absolute percentage error was beten 0.24% and 0.49%, extending at the same time the quantification beyond healthy subjects. HighlightsA novel and improved method for quantifying the retinal vessel calibres was presented.Junction exponents re experimentally derived for different groups, based on the fractal dimension and the branch exponent.New formulas re introduced for summarising the vessel calibres in healthy, diabetic and diabetic retinopathy eyes.The improvement in terms of the mean absolute percentage error ranged from 0.24% to 0.49%."}]