Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: High-throughput cell-based phenotypic screening has become an increasingly important technology for discovering new drug targets and assigning gene functions. Such experiments use hundreds of 96-ll or 384-ll plates, to cover whole-genome RNAi collections and/or chemical compound files, and often collect measurements that are sensitive to spatial background noise whose patterns can vary across individual plates. Correcting these position effects can substantially improve measurement accuracy and screening success.#R##N##R##N#Result:  developed SbacHTS (Spatial background noise correction for High-Throughput RNAi Screening) software for visualization, estimation and correction of spatial background noise in high-throughput RNAi screens. SbacHTS is supported on the Galaxy open-source framework with a user-friendly open access b interface.  find that SbacHTS software can effectively detect and correct spatial background noise, increase signal to noise ratio and enhance statistical detection por in high-throughput RNAi screening experiments.#R##N##R##N#Availability: http://www.galaxy.qbrc.org/#R##N##R##N#Contact: ude.nretsewhtuoSTU@oaiX.auhgnauG#R##N##R##N#Supplementary information: Supplementary data are available at Bioinformatics online.
['Rui Zhong', 'Min Soo Kim', 'Michael A. White', 'Yang Xie', 'Guanghua Xiao']
I am writing a research paper on a idea SbacHTS: Spatial background noise correction for High-Throughput RNAi Screening
[{"from": "human", "value": "I am writing a research paper on a idea SbacHTS: Spatial background noise correction for High-Throughput RNAi Screening"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: High-throughput cell-based phenotypic screening has become an increasingly important technology for discovering new drug targets and assigning gene functions. Such experiments use hundreds of 96-ll or 384-ll plates, to cover whole-genome RNAi collections and/or chemical compound files, and often collect measurements that are sensitive to spatial background noise whose patterns can vary across individual plates. Correcting these position effects can substantially improve measurement accuracy and screening success.#R##N##R##N#Result:  developed SbacHTS (Spatial background noise correction for High-Throughput RNAi Screening) software for visualization, estimation and correction of spatial background noise in high-throughput RNAi screens. SbacHTS is supported on the Galaxy open-source framework with a user-friendly open access b interface.  find that SbacHTS software can effectively detect and correct spatial background noise, increase signal to noise ratio and enhance statistical detection por in high-throughput RNAi screening experiments.#R##N##R##N#Availability: http://www.galaxy.qbrc.org/#R##N##R##N#Contact: ude.nretsewhtuoSTU@oaiX.auhgnauG#R##N##R##N#Supplementary information: Supplementary data are available at Bioinformatics online."}]