Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The frustratometer is an energy landscape theoryinspired algorithm that aims at quantifying the location of frustration manifested in protein molecules. Frustration is a useful concept for gaining insight to the proteins biological behavior by analyzing how the energy is distributed in protein structures and how mutations or conformational changes shift the energetics. Sites of high local frustration often indicate biologically important regions involved in binding or allostery. In contrast, minimally frustrated linkages comprise a stable folding core of the molecule that is conserved in conformational changes. Here,  describe the implementation of these ideas in a bserver freely available at the National EMBNet node—Argentina, at URL: http://lfp.qb.fcen.uba.ar/embnet/.
['Michael Jenik', 'R. Gonzalo Parra', 'Leandro G. Radusky', 'Adrián G. Turjanski', 'Peter G. Wolynes', 'Diego U. Ferreiro']
I am writing a research paper on a idea Protein frustratometer: a tool to localize energetic frustration in protein molecules
[{"from": "human", "value": "I am writing a research paper on a idea Protein frustratometer: a tool to localize energetic frustration in protein molecules"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: The frustratometer is an energy landscape theoryinspired algorithm that aims at quantifying the location of frustration manifested in protein molecules. Frustration is a useful concept for gaining insight to the proteins biological behavior by analyzing how the energy is distributed in protein structures and how mutations or conformational changes shift the energetics. Sites of high local frustration often indicate biologically important regions involved in binding or allostery. In contrast, minimally frustrated linkages comprise a stable folding core of the molecule that is conserved in conformational changes. Here,  describe the implementation of these ideas in a bserver freely available at the National EMBNet node\u2014Argentina, at URL: http://lfp.qb.fcen.uba.ar/embnet/."}]