Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: A basic problem of broad public and scientific interest is to use the DNA of an individual to infer the genomic ancestries of the parents. In particular,  are often interested in the fraction of each parent’s genome that comes from specific ancestries (e.g. European, African, Native American, etc). This has many applications ranging from understanding the inheritance of ancestry-related risks and traits to quantifying human assortative mating patterns. Results:  model the problem of parental genomic ancestry inference as a pooled semi-Markov process.  develop a general mathematical framework for pooled semi-Markov processes and construct efficient inference algorithms for these models. Applying our inference algorithm to genotype data from 231 Mexican trios and 258 Puerto Rican trios where  have the true genomic ancestry of each parent,  demonstrate that our method accurately infers parameters of the semi-Markov processes and parents’ genomic ancestries.  additionally validated the method on simulations. Our model of pooled semi-Markov process and inference algorithms may be of independent interest in other settings in genomics and machine learning. Contact: jazo@microsoft.com
['James Y. Zou', 'Eran Halperin', 'Esteban G. Burchard', 'Sriram Sankararaman']
I am writing a research paper on a idea Inferring parental genomic ancestries using pooled semi-Markov processes
[{"from": "human", "value": "I am writing a research paper on a idea Inferring parental genomic ancestries using pooled semi-Markov processes"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Motivation: A basic problem of broad public and scientific interest is to use the DNA of an individual to infer the genomic ancestries of the parents. In particular,  are often interested in the fraction of each parent\u2019s genome that comes from specific ancestries (e.g. European, African, Native American, etc). This has many applications ranging from understanding the inheritance of ancestry-related risks and traits to quantifying human assortative mating patterns. Results:  model the problem of parental genomic ancestry inference as a pooled semi-Markov process.  develop a general mathematical framework for pooled semi-Markov processes and construct efficient inference algorithms for these models. Applying our inference algorithm to genotype data from 231 Mexican trios and 258 Puerto Rican trios where  have the true genomic ancestry of each parent,  demonstrate that our method accurately infers parameters of the semi-Markov processes and parents\u2019 genomic ancestries.  additionally validated the method on simulations. Our model of pooled semi-Markov process and inference algorithms may be of independent interest in other settings in genomics and machine learning. Contact: jazo@microsoft.com"}]