Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Mutations that allow SIV/HIV to avoid the cytotoxic T lymphocyte (CTL) response are ll documented. Recently, there have been a few attempts at estimating the costs of CTL escape mutations in terms of the reduction in viral fitness and the killing rate at which the CTL response specific to one viral epitope clears virus-infected cells. Using a mathematical model  show that estimation of both parameters depends critically on the underlying changes in the replication rate of the virus and the changes in the killing rate over time (which in previous studies re assumed to be constant).  provide a theoretical basis for estimation of these parameters using in vivo data. In particular,  show that 1) by assuming unlimited virus growth one can obtain a minimal estimate of the fitness cost of the escape mutation, and 2) by assuming no virus growth during the escape, one can obtain a minimal estimate of the average killing rate.  also discuss the conditions under which better estimates of the average killing rate can be obtained.
['Vitaly V. Ganusov', 'Rob J. De Boer']
I am writing a research paper on a idea Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection.
[{"from": "human", "value": "I am writing a research paper on a idea Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection."}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: Mutations that allow SIV/HIV to avoid the cytotoxic T lymphocyte (CTL) response are ll documented. Recently, there have been a few attempts at estimating the costs of CTL escape mutations in terms of the reduction in viral fitness and the killing rate at which the CTL response specific to one viral epitope clears virus-infected cells. Using a mathematical model  show that estimation of both parameters depends critically on the underlying changes in the replication rate of the virus and the changes in the killing rate over time (which in previous studies re assumed to be constant).  provide a theoretical basis for estimation of these parameters using in vivo data. In particular,  show that 1) by assuming unlimited virus growth one can obtain a minimal estimate of the fitness cost of the escape mutation, and 2) by assuming no virus growth during the escape, one can obtain a minimal estimate of the average killing rate.  also discuss the conditions under which better estimates of the average killing rate can be obtained."}]