Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: In the present proof of principle study,  evaluated the homogenous angular spectrum method for passive acoustic mapping (AS-PAM) of microbubble oscillations using simulated and experimental data. In the simulated data  assessed the ability of AS-PAM to form 3D maps of a single and multiple point sources. Then, in the two dimensional limit,  compared the 2D maps from AS-PAM with alternative frequency and time domain passive acoustic mapping (FD- and TD-PAM) approaches. Finally,  assessed the ability of AS-PAM to visualize microbubble activity  in vivo  with data obtained during 8 different experiments of FUS-induced blood-brain barrier disruption in 3 nonhuman primates, using a clinical MR-guided FUS system. Our  in silico  results demonstrate AS-PAM can be used to perform 3D passive acoustic mapping. 2D AS-PAM as compared to FD- PAM and TD-PAM is 10 and 200 times faster respectively and has similar sensitivity, resolution, and localization accuracy, even when the noise was 10-fold higher than the signal.  In-vivo , the AS-PAM reconstructions of emissions at frequency bands pertinent to the different types of microbubble oscillations re also found to be more sensitive than TD-PAM. AS-PAM of harmonic-only components predicted safe blood-brain barrier disruption, whereas AS-PAM of broadband emissions correctly identified MR-evident tissue damage. The disparity (3.2 mm) in the location of the cavitation activity beten the three methods was within their resolution limits. These data clearly demonstrate that AS-PAM is a sensitive and fast approach for PAM, thus providing a clinically relevant method to guide therapeutic ultrasound procedures.
['Costas D. Arvanitis', 'Calum Crake', 'Nathan McDannold', 'Gregory T. Clement']
I am writing a research paper on a idea Passive Acoustic Mapping with the Angular Spectrum Method
[{"from": "human", "value": "I am writing a research paper on a idea Passive Acoustic Mapping with the Angular Spectrum Method"}, {"from": "gpt", "value": "Thats a unique idea.You should consider the following idea to enhance your idea so that it would impact uniquely: In the present proof of principle study,  evaluated the homogenous angular spectrum method for passive acoustic mapping (AS-PAM) of microbubble oscillations using simulated and experimental data. In the simulated data  assessed the ability of AS-PAM to form 3D maps of a single and multiple point sources. Then, in the two dimensional limit,  compared the 2D maps from AS-PAM with alternative frequency and time domain passive acoustic mapping (FD- and TD-PAM) approaches. Finally,  assessed the ability of AS-PAM to visualize microbubble activity  in vivo  with data obtained during 8 different experiments of FUS-induced blood-brain barrier disruption in 3 nonhuman primates, using a clinical MR-guided FUS system. Our  in silico  results demonstrate AS-PAM can be used to perform 3D passive acoustic mapping. 2D AS-PAM as compared to FD- PAM and TD-PAM is 10 and 200 times faster respectively and has similar sensitivity, resolution, and localization accuracy, even when the noise was 10-fold higher than the signal.  In-vivo , the AS-PAM reconstructions of emissions at frequency bands pertinent to the different types of microbubble oscillations re also found to be more sensitive than TD-PAM. AS-PAM of harmonic-only components predicted safe blood-brain barrier disruption, whereas AS-PAM of broadband emissions correctly identified MR-evident tissue damage. The disparity (3.2 mm) in the location of the cavitation activity beten the three methods was within their resolution limits. These data clearly demonstrate that AS-PAM is a sensitive and fast approach for PAM, thus providing a clinically relevant method to guide therapeutic ultrasound procedures."}]