The effects of metformin ( MET ) and curcumin ( CUR ) single treatments have been tested against breast cancer ; however , their combination has not been explored .
Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis.  The effects of metformin ( MET ) and curcumin ( CUR ) single treatments have been tested against breast cancer ; however , their combination has not been explored . Here, we evaluated the antitumor activity of MET and CUR combination against breast cancer in mice. ### Materials And Methods The antiproliferative activity of single and combined treatments against breast cancer cell lines was determined. Vascular endothelial growth factor (VEGF) and ### results The combination treatment exhibited the highest effects against tumor proliferation and growth. It significantly reduced VEGF expression, induced ### conclusion The combination can be a potential therapeutic option to treat breast cancer. However, further testing is needed to measure the exact serum levels of MET and CUR and to further explain the obtained results.
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis.  The effects of metformin ( MET ) and curcumin ( CUR ) single treatments have been tested against breast cancer ; however , their combination has not been explored . Here, we evaluated the antitumor activity of MET and CUR combination against breast cancer in mice. ### Materials And Methods The antiproliferative activity of single and combined treatments against breast cancer cell lines was determined. Vascular endothelial growth factor (VEGF) and ### results The combination treatment exhibited the highest effects against tumor proliferation and growth. It significantly reduced VEGF expression, induced ### conclusion The combination can be a potential therapeutic option to treat breast cancer. However, further testing is needed to measure the exact serum levels of MET and CUR and to further explain the obtained results.

            ### Response:
            metformin, curcumin
            