To our knowledge , we present the first reported case of SS associated with linezolid and methadone with a brief review of the literature .
Serotonin syndrome due to co-administration of linezolid and methadone. Serotonin syndrome (SS), a potentially life-threatening adverse drug reaction caused by excessive serotonergic agonism in central and peripheral nervous system serotonergic receptors, may be caused by a single drug or a combination of drugs with serotonergic activity. The syndrome results in a variety of mental, autonomic and neuromuscular changes, which can range in severity from mild to life-threatening. To our knowledge , we present the first reported case of SS associated with linezolid and methadone with a brief review of the literature .
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            Serotonin syndrome due to co-administration of linezolid and methadone. Serotonin syndrome (SS), a potentially life-threatening adverse drug reaction caused by excessive serotonergic agonism in central and peripheral nervous system serotonergic receptors, may be caused by a single drug or a combination of drugs with serotonergic activity. The syndrome results in a variety of mental, autonomic and neuromuscular changes, which can range in severity from mild to life-threatening. To our knowledge , we present the first reported case of SS associated with linezolid and methadone with a brief review of the literature .

            ### Response:
            linezolid, methadone
            