In order to elucidate the possible interference of the antiparkinson drug 1-aminoadamantane ( D-1 , PK Merz ) and the antispastic compound 1,3-dimethyl-5-aminoadamantane ( DMAA , D-145 , memantine , Memantine ) on neurotransmitter metabolism , the effect of D-1 and its C-alkyl derivatives memantine , 1-amino-3,5,7-trimethyladamantane ( D-191 ) , and 1-amino-3-(n)-butyladamantane ( D-178 ) on MAO activity in brain , liver , and kidney of the rat was investigated .
Effect of 1-aminoadamantanes on the MAO activity in brain, liver, and kidney of the rat.  In order to elucidate the possible interference of the antiparkinson drug 1-aminoadamantane ( D-1 , PK Merz ) and the antispastic compound 1,3-dimethyl-5-aminoadamantane ( DMAA , D-145 , memantine , Memantine ) on neurotransmitter metabolism , the effect of D-1 and its C-alkyl derivatives memantine , 1-amino-3,5,7-trimethyladamantane ( D-191 ) , and 1-amino-3-(n)-butyladamantane ( D-178 ) on MAO activity in brain , liver , and kidney of the rat was investigated . A radioisotope method using [14C]5-hydroxytryptamine as substrate was used. The highest MAO activity was found in liver followed by brain and kidney (Vmax: 137, 64, and 26 nmol/mg protein X h, respectively). The Km values did not differ significantly for the three tissues (liver: 107 mumol/l; brain: 96 mumol/l; kidney: 86 mumol/l). The MAO activity in liver, brain and kidney was noncompetitively inhibited by all 1-aminoadamantanes studied, each derivative, respectively, showing in all three tissues about the same percentage inhibition. The inhibitory activity was found to be increased with the degree of C-alkylation: D-1 (Ki approximately 1 mmol/l) less than D-145 (Ki approximately 0.1 mmol/l) less than D-191 (Ki approximately 0.07 mmol/l) less than D 178 (Ki approximately 0.02 mmol/l).
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            Effect of 1-aminoadamantanes on the MAO activity in brain, liver, and kidney of the rat.  In order to elucidate the possible interference of the antiparkinson drug 1-aminoadamantane ( D-1 , PK Merz ) and the antispastic compound 1,3-dimethyl-5-aminoadamantane ( DMAA , D-145 , memantine , Memantine ) on neurotransmitter metabolism , the effect of D-1 and its C-alkyl derivatives memantine , 1-amino-3,5,7-trimethyladamantane ( D-191 ) , and 1-amino-3-(n)-butyladamantane ( D-178 ) on MAO activity in brain , liver , and kidney of the rat was investigated . A radioisotope method using [14C]5-hydroxytryptamine as substrate was used. The highest MAO activity was found in liver followed by brain and kidney (Vmax: 137, 64, and 26 nmol/mg protein X h, respectively). The Km values did not differ significantly for the three tissues (liver: 107 mumol/l; brain: 96 mumol/l; kidney: 86 mumol/l). The MAO activity in liver, brain and kidney was noncompetitively inhibited by all 1-aminoadamantanes studied, each derivative, respectively, showing in all three tissues about the same percentage inhibition. The inhibitory activity was found to be increased with the degree of C-alkylation: D-1 (Ki approximately 1 mmol/l) less than D-145 (Ki approximately 0.1 mmol/l) less than D-191 (Ki approximately 0.07 mmol/l) less than D 178 (Ki approximately 0.02 mmol/l).

            ### Response:
            PK Merz, memantine, Memantine, memantine
            