In Crohn 's disease in remission after 6 months of azathioprine in combination with infliximab , 63.8 % of practitioners discontinued azathioprine .
Tumour necrosis factor antagonists and inflammatory bowel diseases: a national practice survey. Although the use of tumour necrosis factor (TNF) antagonists is increasingly codified, several unresolved issues remain. ### aim To conduct a French national survey on TNF antagonists use in inflammatory bowel disease (IBD). ### methods A postal questionnaire was sent to all French gastroenterologists among whom 450 prescribe TNF antagonists for IBD. Only anti-TNF prescribers were invited to respond. ### results A total of 333 questionnaires could be analysed, which represented a rate of survey completeness of 74%. Scheduled maintenance infliximab treatment was prescribed by 92% of gastroenterologists. In Crohn's disease in remission after 1 year of TNF antagonists, 77.4% of physicians continued treatment. In luminal Crohn's disease, 97% of hospital practitioners introduced infliximab as first-line anti-TNF therapy vs. 78% of physicians with nonhospital activity (P = 0.002); only 22.5% of gastroenterologists opted for adalimumab as first-line therapy. In Crohn 's disease in remission after 6 months of azathioprine in combination with infliximab , 63.8 % of practitioners discontinued azathioprine . In case of pregnancy during anti-TNF treatment, 35.1% of physicians discontinued therapy at the time of conception and did not administer anti-TNF therapy during pregnancy. ### conclusions The attitudes of French gastroenterologists generally reflect the recommendations regarding the use of anti-TNF and concomitant immunosuppressive therapy in IBD.
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            Tumour necrosis factor antagonists and inflammatory bowel diseases: a national practice survey. Although the use of tumour necrosis factor (TNF) antagonists is increasingly codified, several unresolved issues remain. ### aim To conduct a French national survey on TNF antagonists use in inflammatory bowel disease (IBD). ### methods A postal questionnaire was sent to all French gastroenterologists among whom 450 prescribe TNF antagonists for IBD. Only anti-TNF prescribers were invited to respond. ### results A total of 333 questionnaires could be analysed, which represented a rate of survey completeness of 74%. Scheduled maintenance infliximab treatment was prescribed by 92% of gastroenterologists. In Crohn's disease in remission after 1 year of TNF antagonists, 77.4% of physicians continued treatment. In luminal Crohn's disease, 97% of hospital practitioners introduced infliximab as first-line anti-TNF therapy vs. 78% of physicians with nonhospital activity (P = 0.002); only 22.5% of gastroenterologists opted for adalimumab as first-line therapy. In Crohn 's disease in remission after 6 months of azathioprine in combination with infliximab , 63.8 % of practitioners discontinued azathioprine . In case of pregnancy during anti-TNF treatment, 35.1% of physicians discontinued therapy at the time of conception and did not administer anti-TNF therapy during pregnancy. ### conclusions The attitudes of French gastroenterologists generally reflect the recommendations regarding the use of anti-TNF and concomitant immunosuppressive therapy in IBD.

            ### Response:
            azathioprine, infliximab, azathioprine
            