Eligible patients ( n = 17 ) were divided into 2 groups receiving a combined chemotherapy of intravenous cisplatinum ( 70 mg/m2 ) and cyclophosphamide ( 700 mg/m2 ) with or without the addition of Lenograstim .
The use of lenograstim (Granocyte) in chemotherapy for ovarian cancer. We have conducted an open, controlled study on the febrile neutropenia effects by lenograstim (Granocyte) therapy following cytotoxic chemotherapy of cisplatinum and cyclophosphamide in patients with primary advanced epithelial ovarian cancer. Eligible patients ( n = 17 ) were divided into 2 groups receiving a combined chemotherapy of intravenous cisplatinum ( 70 mg/m2 ) and cyclophosphamide ( 700 mg/m2 ) with or without the addition of Lenograstim . Subcutaneous administration of lenograstim (100 micrograms/day) for 7 consecutive days was given from day 8 to day 14 of the 3rd to the 5th cycle of chemotherapy in lenograstim treated patients. After 3 cycles of treatment, lenograstim treated patients (group 1, n = 10) showed a significant improvement in white blood cell (WBC) count as compared with group 2 (control) of 7 patients (p = 0.00002). Group 1 patients also showed an increased C-reactive protein, though of no significance. There were no significant differences among the 2 groups regarding ESR, hematocrit, platelet counts and blood chemistry profiles. This preliminary data encourages more study of the benefits of lenograstim in the treatment of ovarian cancer.
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            The use of lenograstim (Granocyte) in chemotherapy for ovarian cancer. We have conducted an open, controlled study on the febrile neutropenia effects by lenograstim (Granocyte) therapy following cytotoxic chemotherapy of cisplatinum and cyclophosphamide in patients with primary advanced epithelial ovarian cancer. Eligible patients ( n = 17 ) were divided into 2 groups receiving a combined chemotherapy of intravenous cisplatinum ( 70 mg/m2 ) and cyclophosphamide ( 700 mg/m2 ) with or without the addition of Lenograstim . Subcutaneous administration of lenograstim (100 micrograms/day) for 7 consecutive days was given from day 8 to day 14 of the 3rd to the 5th cycle of chemotherapy in lenograstim treated patients. After 3 cycles of treatment, lenograstim treated patients (group 1, n = 10) showed a significant improvement in white blood cell (WBC) count as compared with group 2 (control) of 7 patients (p = 0.00002). Group 1 patients also showed an increased C-reactive protein, though of no significance. There were no significant differences among the 2 groups regarding ESR, hematocrit, platelet counts and blood chemistry profiles. This preliminary data encourages more study of the benefits of lenograstim in the treatment of ovarian cancer.

            ### Response:
            cisplatinum, cyclophosphamide, Lenograstim
            