The incident number of the infected mice was significantly different among groups with different drugs and doses : 2/60 , 16/60 , 10/60 and 10/60 in the groups of Changqing capsule , spiramycin , pyrimethamine and azithromycin respectively ( P < 0.05 ) .
[In vitro effect of combined traditional Chinese medicine (Changqing capsule) on the tachyzoites of Toxoplasma gondii]. To detect the in vitro effect of the traditional Chinese medicine on the tachyzoites of Toxoplasma gondii. ### methods Supernatant (1.5 ml) of different doses of the traditional Chinese medicine (Changqing capsule) was collected by normal saline immersion and 2.5 x 10(4) Toxoplasma gondii tachyzoites were added in each paste well for 8 hours. spiramycin, pyrimethamine and azithromycin in different doses were used as controls. Normal saline was used as negative control. Mice were inoculated with drug-treated tachyzoites intraperitoneally or intragastrically. The normal mice were subcultured after 8 days for 3 generations. ### results The incident number of the infected mice was significantly different among groups with different drugs and doses : 2/60 , 16/60 , 10/60 and 10/60 in the groups of Changqing capsule , spiramycin , pyrimethamine and azithromycin respectively ( P < 0.05 ) . No mice were found incident in groups of high and medium dose Changqing capsule while 2 out of 20 found sick in the low dose group (P < 0.05). The subculture observation showed that 2 and 1 mice in the first generation of the low dose Changqing capsule group inoculated intraperitonelly and intragastrically were found infected respectively. 2 mice of the second generation in low dose spiramycin group and 1 mouse of the third generation in low dose pyrimethamine group were also found infected. ### conclusion The in vitro killing effect of the Changqing capsule on the tachyzoites of Toxoplasma gondii is better than the current clinical drugs and shows a positive correlation with the dosages.
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            [In vitro effect of combined traditional Chinese medicine (Changqing capsule) on the tachyzoites of Toxoplasma gondii]. To detect the in vitro effect of the traditional Chinese medicine on the tachyzoites of Toxoplasma gondii. ### methods Supernatant (1.5 ml) of different doses of the traditional Chinese medicine (Changqing capsule) was collected by normal saline immersion and 2.5 x 10(4) Toxoplasma gondii tachyzoites were added in each paste well for 8 hours. spiramycin, pyrimethamine and azithromycin in different doses were used as controls. Normal saline was used as negative control. Mice were inoculated with drug-treated tachyzoites intraperitoneally or intragastrically. The normal mice were subcultured after 8 days for 3 generations. ### results The incident number of the infected mice was significantly different among groups with different drugs and doses : 2/60 , 16/60 , 10/60 and 10/60 in the groups of Changqing capsule , spiramycin , pyrimethamine and azithromycin respectively ( P < 0.05 ) . No mice were found incident in groups of high and medium dose Changqing capsule while 2 out of 20 found sick in the low dose group (P < 0.05). The subculture observation showed that 2 and 1 mice in the first generation of the low dose Changqing capsule group inoculated intraperitonelly and intragastrically were found infected respectively. 2 mice of the second generation in low dose spiramycin group and 1 mouse of the third generation in low dose pyrimethamine group were also found infected. ### conclusion The in vitro killing effect of the Changqing capsule on the tachyzoites of Toxoplasma gondii is better than the current clinical drugs and shows a positive correlation with the dosages.

            ### Response:
            spiramycin, pyrimethamine, azithromycin
            