The efficacy of methotrexate ( MTX ) as a single graft-versus-host disease ( GVHD ) prophylaxis agent was compared to that of cyclosporin A ( CSA ) in 62 pediatric patients ( median age : 8 years ) with hematological malignancies who had undergone bone marrow transplantation ( BMT ) from HLA-identical sibling donors at National Kyushu Cancer Center since 1977 .
Methotrexate vs Cyclosporin A as a single agent for graft-versus-host disease prophylaxis in pediatric patients with hematological malignancies undergoing allogeneic bone marrow transplantation from HLA-identical siblings: a single-center analysis in Japan.  The efficacy of methotrexate ( MTX ) as a single graft-versus-host disease ( GVHD ) prophylaxis agent was compared to that of cyclosporin A ( CSA ) in 62 pediatric patients ( median age : 8 years ) with hematological malignancies who had undergone bone marrow transplantation ( BMT ) from HLA-identical sibling donors at National Kyushu Cancer Center since 1977 . In all, 30 patients received MTX by intravenous bolus injection, with a dose of 15 mg/m(2) on day +1, followed by 10 mg/m(2) on days +3, +6, and +11, and then once a week until day +100. A total of 32 patients were treated with CSA, which was given intravenously in the early stages and orally thereafter until day +100, and then gradually tapered and stopped 6 months after BMT. There were no differences between the groups in terms of rates of hematopoietic recovery after BMT. The probabilities of acute GVHD (grades II-IV) and chronic GVHD were 29.6 vs 40.6% (P=0.294) and 19 vs 20% (MTX vs CSA), respectively. Relapse rates and event-free survival were identical. These results suggest that MTX and CSA were equally effective when given after BMT in Japanese pediatric patients with hematological malignancies. Since MTX was given over a shorter time than CSA, it might be more practical in the management of such patients.
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            Methotrexate vs Cyclosporin A as a single agent for graft-versus-host disease prophylaxis in pediatric patients with hematological malignancies undergoing allogeneic bone marrow transplantation from HLA-identical siblings: a single-center analysis in Japan.  The efficacy of methotrexate ( MTX ) as a single graft-versus-host disease ( GVHD ) prophylaxis agent was compared to that of cyclosporin A ( CSA ) in 62 pediatric patients ( median age : 8 years ) with hematological malignancies who had undergone bone marrow transplantation ( BMT ) from HLA-identical sibling donors at National Kyushu Cancer Center since 1977 . In all, 30 patients received MTX by intravenous bolus injection, with a dose of 15 mg/m(2) on day +1, followed by 10 mg/m(2) on days +3, +6, and +11, and then once a week until day +100. A total of 32 patients were treated with CSA, which was given intravenously in the early stages and orally thereafter until day +100, and then gradually tapered and stopped 6 months after BMT. There were no differences between the groups in terms of rates of hematopoietic recovery after BMT. The probabilities of acute GVHD (grades II-IV) and chronic GVHD were 29.6 vs 40.6% (P=0.294) and 19 vs 20% (MTX vs CSA), respectively. Relapse rates and event-free survival were identical. These results suggest that MTX and CSA were equally effective when given after BMT in Japanese pediatric patients with hematological malignancies. Since MTX was given over a shorter time than CSA, it might be more practical in the management of such patients.

            ### Response:
            methotrexate, cyclosporin
            