Comparing the combination of nalidixic acid and metronidazole with metronidazole alone , 17.5 % more children treated with the combination recovered by day 3 of treatment ( p = 0.08 ) and the mean stool frequency ascertained on day 7 for the previous 24 h was 26.8 % less in them ( p = 0.05 ) .
Efficacy of antimicrobial treatment in non-dysenteric persistent diarrhoea in a community setting. To determine the efficacy of antimicrobial treatment in non-dysenteric persistent diarrhoea in a community setting. ### methods In this double-blind field trial, 156 children aged 4-36 months with persistent diarrhoea not associated with Giardia lamblia infestation seeking treatment in a community outpatient clinic, were randomized to receive a combination of nalidixic acid and metronidazole, metronidazole alone, or placebo for 7 days. ### results In comparison with placebo, metronidazole treatment did not result in a significant reduction in the mean post-enrollment diarrhoeal duration and stool frequency, increase in the proportion of patients recovered by days 3, 5 and 7 of treatment, and increase in weight gain at days 7 and 14. Comparing the combination of nalidixic acid and metronidazole with metronidazole alone , 17.5 % more children treated with the combination recovered by day 3 of treatment ( p = 0.08 ) and the mean stool frequency ascertained on day 7 for the previous 24 h was 26.8 % less in them ( p = 0.05 ) . The weight gains at days 7 and 14 were similar in the two groups. ### conclusions These findings indicate that metronidazole offers no therapeutic benefit in persistent diarrhoea not associated with Giardia lamblia and nalidixic acid has only a modest clinical benefit, which is not substantial enough to warrant its routine use.
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            Efficacy of antimicrobial treatment in non-dysenteric persistent diarrhoea in a community setting. To determine the efficacy of antimicrobial treatment in non-dysenteric persistent diarrhoea in a community setting. ### methods In this double-blind field trial, 156 children aged 4-36 months with persistent diarrhoea not associated with Giardia lamblia infestation seeking treatment in a community outpatient clinic, were randomized to receive a combination of nalidixic acid and metronidazole, metronidazole alone, or placebo for 7 days. ### results In comparison with placebo, metronidazole treatment did not result in a significant reduction in the mean post-enrollment diarrhoeal duration and stool frequency, increase in the proportion of patients recovered by days 3, 5 and 7 of treatment, and increase in weight gain at days 7 and 14. Comparing the combination of nalidixic acid and metronidazole with metronidazole alone , 17.5 % more children treated with the combination recovered by day 3 of treatment ( p = 0.08 ) and the mean stool frequency ascertained on day 7 for the previous 24 h was 26.8 % less in them ( p = 0.05 ) . The weight gains at days 7 and 14 were similar in the two groups. ### conclusions These findings indicate that metronidazole offers no therapeutic benefit in persistent diarrhoea not associated with Giardia lamblia and nalidixic acid has only a modest clinical benefit, which is not substantial enough to warrant its routine use.

            ### Response:
            nalidixic acid, metronidazole, metronidazole
            