Growth inhibition was measured by 3H-thymidine incorporation assays for doxorubicin hydrochloride ( ADM ) , mitomycin C ( MMC ) , cisplatin ( CDDP ) , and etoposide ( VP-16 ) , and by Alamar Blue assay for ( AB assay ) 5-fluorouracil ( 5-FU ) .
In vitro chemosensitivity of human pancreatic cancer cell lines. These results show that eight pancreatic cancer cell lines are broadly sensitive to CDDP, and that chemotherapy for pancreatic cancer may improve the prognosis by more effective drug delivery to cancer cells. ### background Chemotherapy for pancreatic cancer does not satisfactorily improve prognosis. The efficacy of chemotherapy depends on choosing sensitive anticancer drugs. ### methods The in vitro chemosensitivity of eight human pancreatic cancer cell lines was investigated. Growth inhibition was measured by 3H-thymidine incorporation assays for doxorubicin hydrochloride ( ADM ) , mitomycin C ( MMC ) , cisplatin ( CDDP ) , and etoposide ( VP-16 ) , and by Alamar Blue assay for ( AB assay ) 5-fluorouracil ( 5-FU ) . The cells were exposed to ADM, MMC, CDDP, and VP-16 for 2 h, and 5-FU for 72 h. From the dose-response curves, the 50% growth inhibition (IC50) level for each drug was estimated. ### results The IC50 after 2 h of exposure of each of the eight kinds of cell lines to each anticancer drug ranged from 0.12-8.2 micrograms/mL for ADM, 0.066-25 micrograms/mL for MMC, 0.57-7 micrograms/mL for CDDP, 0.68-300 micrograms/mL for VP-16. IC50 after 72 h of exposure to 5-FU ranged from 1.8-23 micrograms/mL.
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            In vitro chemosensitivity of human pancreatic cancer cell lines. These results show that eight pancreatic cancer cell lines are broadly sensitive to CDDP, and that chemotherapy for pancreatic cancer may improve the prognosis by more effective drug delivery to cancer cells. ### background Chemotherapy for pancreatic cancer does not satisfactorily improve prognosis. The efficacy of chemotherapy depends on choosing sensitive anticancer drugs. ### methods The in vitro chemosensitivity of eight human pancreatic cancer cell lines was investigated. Growth inhibition was measured by 3H-thymidine incorporation assays for doxorubicin hydrochloride ( ADM ) , mitomycin C ( MMC ) , cisplatin ( CDDP ) , and etoposide ( VP-16 ) , and by Alamar Blue assay for ( AB assay ) 5-fluorouracil ( 5-FU ) . The cells were exposed to ADM, MMC, CDDP, and VP-16 for 2 h, and 5-FU for 72 h. From the dose-response curves, the 50% growth inhibition (IC50) level for each drug was estimated. ### results The IC50 after 2 h of exposure of each of the eight kinds of cell lines to each anticancer drug ranged from 0.12-8.2 micrograms/mL for ADM, 0.066-25 micrograms/mL for MMC, 0.57-7 micrograms/mL for CDDP, 0.68-300 micrograms/mL for VP-16. IC50 after 72 h of exposure to 5-FU ranged from 1.8-23 micrograms/mL.

            ### Response:
            doxorubicin, mitomycin, cisplatin, etoposide
            