Ultimately , the patient was successfully treated with combination therapy of Liposomal amphotericin B and Miltefosine without any relapse .
A rare case of Visceral leishmaniasis with multiple relapse and multi-drug unresponsive: successfully treated with combination therapy. We report a 32-year old relapse case of Visceral leishmaniasis, treated with paromomycin who belonged from a endemic zone of Bihar state, India. After confirmation, he was treated with amphotericin B, followed by Liposomal amphotericin B in full course and even in higher dose. But after each therapy, the patient either did not responded or relapsed after treatment. Ultimately , the patient was successfully treated with combination therapy of Liposomal amphotericin B and Miltefosine without any relapse . ### conclusion The multi-drug unresponsive Visceral leishmaniasis cases could pose a major threat to treatment strategy in the elimination program. In such situation, combination therapy seems to be a better approach that needs to be explored.
### Instruction:
            Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds 
            that can co-occur for the mentioned treatment

            ### Input:
            A rare case of Visceral leishmaniasis with multiple relapse and multi-drug unresponsive: successfully treated with combination therapy. We report a 32-year old relapse case of Visceral leishmaniasis, treated with paromomycin who belonged from a endemic zone of Bihar state, India. After confirmation, he was treated with amphotericin B, followed by Liposomal amphotericin B in full course and even in higher dose. But after each therapy, the patient either did not responded or relapsed after treatment. Ultimately , the patient was successfully treated with combination therapy of Liposomal amphotericin B and Miltefosine without any relapse . ### conclusion The multi-drug unresponsive Visceral leishmaniasis cases could pose a major threat to treatment strategy in the elimination program. In such situation, combination therapy seems to be a better approach that needs to be explored.

            ### Response:
            amphotericin, Miltefosine
            