Systemic Blood Pressure Outline
Human Physiology
I. Systemic Blood PressureA. Systolic vs. Diastolic1. Definition
2. Measure directly
3. Measure indirectlyB. Influencing factors1. Cardiac output
2. Stroke volume = end- diastolic volume – end-systolic volume
3. EDV factorsa. Atrial pressure
b. Ventricular compliance
4. ESV factorsa. Ventricular contractility1. Frank-Starling law of the heart
2. Effect of the SNS


b. Ventricular afterload


5. Heart rate
6. Ejection fractionC. Pulse Pressure1. Definition
2. PP directly related to:
3. PP is inversely related to:D. Mean Arterial PressureApproximation when at restII. Blood FlowA. Autoregulation of capillary flow1. Review
2. Active tissues
3. Inactive tissuesB. Autonomic Regulation of ArteriolesIII. Capillary dynamicsA. Starling forces: filtration versus absorptionAcross the capillary:1. Filtration forces: outwarda. Hydrostatic blood pressure
b. Tissue protein osmotic pressure2. Absorption forces: inwarda. Plasma protein osmotic pressure
b. Tissue hydrostatic pressure

3. Overall EquationArterial end
Venous end


B. Role of the lymphatic systemC. Peripheral edema:Increase in Outward
Decrease in the inwardIV. Pulmonary versus Systemic Pressure and FlowA. Pulmonary Flow = Systemic Flow
B. Pulmonary pressure differential < Systemic pressure differentialC. Pulmonary resistance< Systemic ResistanceD. Regulation of Flow1. Systemica. High pressure
b. Into CO22. Pulmonarya. Low pressure
b. Into O2E. Capillary Dynamics1. Systemic capillary
2. Pulmonary Capillary
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