Увеличение на броя ретикулоцити < 40 000/ µl и повишаване на Hb < 1 g/ dl
If haemoglobin level exceeds 12 g/dl (7.5 mmol/l), discontinue therapy until it falls to 12 g/dl (7.5 mmol/l) or lower and then reinstitute Silapo therapy at a dose 25% below the previous dose.