Изисква се повишено внимание и по- строг клиничен мониторинг, когато тези лекарства се комбинират с миртазапин.
John's Wort – Hypericum perforatum – preparations) may lead to an incidence of serotonin associated effects (serotonin syndrome: see section 4.4) Caution should be advised and a closer clinical monitoring is required when these drugs are combined with mirtazapine.