Kaletra съдържа лопинавир и ритонавир, които са инхибитори на CYP3A изоформата на P450 in vitro.
In HIV-infected patients with severe immune deficiency at the time of institution of combination antiretroviral therapy (CART), an inflammatory reaction to asymtomatic or residual opportunistic pathogens may arise and cause serious clinical conditions, or aggravation of symptoms.