13 (↑29%) или циметидин (↑19%) води до промяна между 20% и 30% в Cmax и AUC на Sprimeo.
Co-administration of aliskiren with either valsartan (↓ 28%), metformin (↓ 28%), amlodipine (↑ 29%) or cimetidine (↑ 19%) resulted in between 20% and 30% change in Cmax or AUC of Sprimeo.