Предполага се, че тези симптоми се дължат на подобрение на имунния отговор на организма, даващ възможност на организма да се бори с инфекцията, която може да е съществувала и без изявени симптоми.
It is believed that these symptoms are due to an improvement in the body’s immune response, enabling the body to fight infections that may have been present with no obvious symptoms. − Joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement as some patients taking these medicines may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).