Увеличение на броя ретикулоцити < 40 000/ μl и повишаване на Hb < 1 g/ dl
If the haemoglobin increase is < 1 g/ dl (< 0.62 mmol/ l) and the reticulocyte count has increased < 40,000 cells/ µl above baseline, increase the dose to 300 IU/ kg 3 times per week.