По тази причина при продължително лечение може да повлияе фолатния метаболизъм (вж. точка 4. 6).
However, during prolonged human dosing, lamotrigine did not induce significant changes in the haemoglobin concentration, mean corpuscular volume, or serum or red blood cell folate concentrations up to 1 year or red blood cell folate concentrations for up to 5 years.