В проучването AC- 052- 331, в срока на 24- седмичното двойно- сляпо лечение, съответните стойности са 1, 9 спрямо 2, 7 новопоявили се дигитални язви, (p = 0, 0351).
In both studies, patients on bosentan were less likely to develop multiple new digital ulcers during the study and took longer to develop each successive new digital ulcer than did those on placebo.