Метаболит 25- O- дезацетил- рифабутин AUC ↑ 1, 24 (0, 84- 1, 84) Метаболит 25- O- дезацетил- рифабутин Cmin ↑ 1, 22 (0, 86- 1, 74) Метаболит 25- O- дезацетил- рифабутин Cmax ↑ 1, 29 (0, 98- 1, 68)
Metabolite 25-O-desacetylrifabutin AUC ↑ 1.24 (0.84-1.84) Metabolite 25-O-desacetylrifabutin Cmin ↑ 1.22 (0.86-1.74) Metabolite 25-O-desacetylrifabutin Cmax ↑ 1.29 (0.98-1.68) A clinically not relevant increase in the apparent clearance of nevirapine (by 9%) compared to historical data was reported.