Rifampicin, phenytoin, carbamazepin, phenobarbital og dexamethason virker inducerende på CYP3A4 og kan accelerere metabolismen af sibutramin, omend dette ikke er undersøgt i forsøg.
On the basis of the submitted data the CPMP concluded that in general, the findings do not differ from results already known and assessed in its Opinion of the previous Article 12 procedure.