Progression af handikapudvikling var defineret som mindst 1, 0 point stigning i EDSS fra en baseline EDSS > =1, 0 fortsat i 12 eller 24 uger eller mindst 1, 5 point stigning i EDSS fra en baseline EDSS =0 fortsat i 12 eller 24 uger.
Progression of disability was defined as at least a 1.0 point increase on the EDSS from a baseline EDSS > =1.0 sustained for 12 or 24 weeks or at least a 1.5 point increase on the EDSS from a baseline EDSS =0 sustained for 12 or 24 weeks.