Der er observeret nedsat forekomst af hepatisk veneoklussion (HVOD) og anden behandlingsrelateret toksicitet hos patienter, hvor tidsrummet mellem sidste dosis busulfan og første dosis cyclophosphamid er > 24 timer.
A reduced incidence of Hepatic Veino Occlusive Disease (HVOD) and other regimen- related toxicity have been observed in patients when the lag time between the last dose of oral busulfan and the first dose of cyclophosphamide is > 24hours.