COX- 2 er også involveret i ovulation, implantation og lukning af ductus arteriosus, regulering af nyrefunktionen og funktioner i centralnervesystemet (induktion af feber, smerteopfattelse og kognitive funktioner).
COX-2 is also involved in ovulation, implantation and closure of the ductus arteriosus, regulation of renal function, and central nervous system functions (fever induction, pain perception and cognitive function).