Desirudin er kontraindiceret hos patienter med svært nedsat nyrefunktion (kreatininclearence mindre end 30 ml/ min., svarende til serumkreatinin > 2, 5 mg/ dl eller 221μmol/ l); se pkt.
Desirudin is contraindicated in patients with severe renal impairment (creatinine clearance of less than 30ml/ min corresponding to a serum creatinine > 2.5mg/ dl or 221μ mol/ l; see section 4.3).