I et placebo- kontrolleret studie med 651 patienter, med klinisk kompenseret kronisk hepatitis B og histologisk bekræftet fibrose eller cirrhosis, reducerede lamivudin behandling (middelvarighed 32 måneder) signifikant hyppigheden af overordnet sygdomsprogression, (34/ 436, 7. 8% for lamivudin versus 38/ 215, 17. 7% for placebo, p=0. 001), demonstreret ved en signifikant reduktion i andelen af patienter der havde øget Child- Pugh scores (15/ 436, 3. 4% versus 19/ 215, 8. 8%, p=0. 023) eller udviklende hepatocellulær carcinoma (17/ 436, 3. 9% versus 16/ 215, 7. 4%, p=0. 047).
Experience in CHB patients with advanced fibrosis or cirrhosis: in a placebo-controlled study in 651 patients with clinically compensated chronic hepatitis B and histologically confirmed fibrosis or cirrhosis, lamivudine treatment (median duration 32 months) significantly reduced the rate of overall disease progression (34/ 436, 7.8% for lamivudine versus 38/ 215, 17.7% for placebo, p=0.001), demonstrated by a significant reduction in the proportion of patients having increased Child-Pugh scores (15/ 436, 3.4% versus 19/ 215, 8.8%, p=0.023) or developing hepatocellular carcinoma (17/ 436, 3.9% versus 16/ 215, 7.4%, p=0.047).