Hos mus ses ingen statistisk signifikant stigning i hyppigheden af tumorer ved en systemisk eksponering fra 7- 39 gange den humane eksponering (ubundet AUC0- 24 timers måling) ved en dosis på 300 mg 2 gange dagligt.
In mice, no statistically significant increase in the incidence of tumors was reported at systemic exposures from 7 to 39-times the human exposure (unbound AUC 0-24h measurement) at a dose of 300 mg twice daily.