Doripenem er stabilt over for hydrolyse forårsaget af de fleste betalaktamaser, bl. a. penicillinaser og cefalosporinaser produceret af grampositive og gramnegative bakterier, bortset fra relativt sjældne carbapenemhydrolyserende betalaktamaser.
Doripenem is stable to hydrolysis by most beta-lactamases, including penicillinases and cephalosporinases produced by gram-positive and gram-negative bacteria, with the exception of relatively rare carbapenem hydrolyzing beta-lactamases.