Hos patienter med kronisk alkoholisk leversygdom var AUC og den maksimale plasmakoncentration (Cmax) for loratadin fordoblet, mens den farmakokinetiske profil af den aktive metabolit ikke var signifikant ændret i forhold til patienter med normal leverfunktion.
In patients with chronic alcoholic liver disease, the AUC and peak plasma levels (Cmax) of loratadine were double while the pharmacokinetic profile of the active metabolite was not significantly changed from that in patients with normal liver function.