1, 7 eller 1 gang den humane daglige eksponering (baseret på AUC) på henholdsvis 400 mg/ dag eller 800 mg/ dag, og 1, 2 gange den daglige eksponering hos børn (baseret på AUC) på 340 mg/ m2/ dag.
The renal adenoma/ carcinoma, the urinary bladder and urethra papilloma, the small intestine adenocarcinomas, the parathyroid glands adenomas, the benign and malignant medullary tumours of the adrenal glands and the non-glandular stomach papillomas/ carcinomas were noted at 60 mg/ kg/ day, representing approximately 1.7 or 1 times the human daily exposure (based on AUC) at 400 mg/ day or 800 mg/ day, respectively, and 1.2 times the daily exposure in children (based on AUC) at 340 mg/ m2/ day.