I toksicitetsstudier med gentagne doser blev der observeret lette reversible leverforandringer i rotter, disse leverforandringer begyndte ved ca.
In anesthetized dogs and Cynomolgus monkeys, at intravenous doses of 15-60 mg/ kg, slowing of atrial and ventricular conductivity, atrioventricular block and atrioventricular dissociation were seen.