Selvom samtidig administration af OPV svagt kan nedsætte immunresponset overfor rotavirus- vaccine, blev den kliniske beskyttelse mod alvorlig rotavirus gastro- enteritis opretholdt i et klinisk forsøg med 4. 200 børn, som fik Rotarix samtidig med OPV.
Although concomitant administration of OPV may slightly reduce the immune response to rotavirus vaccine, clinical protection against severe rotavirus gastro-enteritis was shown to be maintained in a clinical trial involving more than 4200 subjects who received Rotarix concomitantly with OPV.