Populationsfarmakokinetik Hos patienter med pulmonal arteriel hypertension er de gennemsnitlige steady state koncentrationer 20- 50% højere end de undersøgte doser på 20- 80 mg 3 gange dagligt sammenlignet med raske frivillige forsøgspersoner.
In patients with pulmonary arterial hypertension, the average steady state concentrations were 20 – 50% higher over the investigated dose range of 20– 80 mg three times a day compared to healthy volunteers.