Atten procent af isolaterne havde 4 eller mere af følgende 6 substitutioner, som anses for kritiske substitutioner for proteasehæmmere: position L10, M46, I54, V82, I84 og L90.
Eighteen percent of isolates had 4 or more of the following 6 substitutions considered critical substitutions for protease inhibitors: positions L10, M46, I54, V82, I84, and L90.