Dosis bør reduceres med cirka 25%, hvis hastigheden for stigningen i hæmoglobinkoncentrationen er større end 2 g/ dl (1, 25 mmol/ l) på en måned, eller hvis hæmoglobinniveauet stiger og nærmer sig 12 g/ dl (7, 5 mmol/ l).
If it occurs, appropriate dose adjustment should be made as provided. If the rate of rise in haemoglobin is greater than 2 g/ dl (1.25 mmol/ l) in one month or if the haemoglobin level is increasing and approaching 12 g/ dl (7.45 mmol/ l), the dose is to be reduced by approximately 25%.