Iloprost kan hæmme trombocytternes funktion, og det kan forøge risikoen for blødning, hvis det anvendes sammen med antikoagulanter (som f. eks. heparin, antikoagulanter af coumarin- typen) eller andre hæmmere af trombocytaggregation (som f. eks. acetylsalicylsyre, non- steroide anti - inflammatoriske lægemidler, ticlopidin, clopidogrel og glykoprotein IIb/ IIIa antagonister: abciximab, eptifibatide og tirofiban).
5 Iloprost can inhibit platelet function and its use with anticoagulants (such as heparin, coumarin-type anticoagulants) or other inhibitors of platelet aggregation (such as acetylsalicylic acid, non-steroidal anti-inflammatory medicinal products, ticlopidine, clopidogrel and glycoprotein IIb/ IIIa antagonists: abciximab, eptifibatide and tirofiban) may increase the risk of bleeding.