Personer med komplement sygdomme eller med funktionel eller anatomisk asplenia opnår et immunrespons for Hib og MenC konjugerede vacciner; graden af den opnåede beskyttelse er dog ukendt.
Individuals with complement deficiencies and individuals with functional or anatomical asplenia may mount an immune response to Hib and MenC conjugate vaccines; however the degree of protection that would be afforded is unknown.