Omvendt forventes det ikke, at mutationer i gp41 aminosyrerne 36- 45, som forårsager resistens over for enfuvirtid, vil forårsage resistens over for andre antiretrovirale lægemiddelgrupper.
Conversely, mutations in aa 36-45 of gp41 which give resistance to enfuvirtide would not be expected to give cross resistance to other classes of antiretrovirals.