Efter intravenøs administration af 0, 5 mg ibandronsyre faldt den totale, renale og ikke- renale clearance hos patienter med svær nyrefunktions - nedsættelse, med henholdsvis 67%, 77% og 50%, men der fandtes ikke nedsat tolerabilitet i forbindelse med den øgede eksponering.
After intravenous administration of 0.5 mg of ibandronic acid, total, renal, and non-renal clearances decreased by 67%, 77% and 50%, respectively, in subjects with severe renal failure, but there was no reduction in tolerability associated with the increase in exposure.