Bortezomib var positivt for klastogen aktivitet (strukturelle kromosomafvigelser) i in vitro- analysen af kromosomafvigelser ved hjælp af ovarieceller fra kinesiske hamstre (CHO) i koncentrationer så lave som 3, 125 µg/ ml, som var den lavest vurderede koncentration.
Bortezomib was positive for clastogenic activity (structural chromosomal aberrations) in the in vitro chromosomal aberration assay using Chinese hamster ovary (CHO) cells at concentrations as low as 3.125 μ g/ ml, which was the lowest concentration evaluated.