Vardenafil metaboliseres hovedsagelig i leveren via cytokrom P450 (CYP) - isoformen 3A4 men også via CYP3A5 - og CYP2C- isoformer.
Vardenafil is metabolised predominantly by hepatic metabolism via cytochrome P450 (CYP) isoform 3A4 with some contribution from CYP3A5 and CYP2C isoforms.