Hæmning af ACE resulterer i nedsat plasmaangiotensin II, som medfører øget plasmareninaktivitet (pga. fjernelse af negativ feed back fra reninfrigørelse) og nedsat aldosteronsekretion.
Inhibition of ACE results in decreased plasma angiotensin II, which leads to increased plasma renin activity (due to removal of negative feedback of renin release), and decreased aldosterone secretion.