Forsøg 2 var et randomiseret, dobbeltblindet, double- dummy, kontrolleret, 3 x 3 multifaktorielt forsøg, som sammenlignede to forskellige doser af rituximab med eller uden en af to kortikosteriodregimer i kombination med ugentlig methotrexat hos patienter med aktiv reumatoid arthritis og som ikke havde responderet på behandling med 1- 5 andre DMARDs.
Study 2 was a randomized, double-blind, double-dummy, controlled, 3 x 3 multifactorial study which compared two different dose levels of rituximab given with or without one of two peri infusional corticosteroid regimens in combination with weekly methotrexate in patients with active rheumatoid arthritis which had not responded to treatment with 1 to 5 other DMARDs.