Hos gnavere sås en markant induktion af CYP2B og en moderat induktion af CYP1A og CYP3A fra 125 mg/ kg/ døgn, mens induktionen hos aber var beskeden for CYP2B og CYP3A med 375 mg/ kg/ døgn.
In rodents, a marked induction of CYP2B and a moderate induction of CYP1A and CYP3A were seen from 125 mg/ kg/ day whereas in monkeys the induction was slight for CYP2B and CYP3A at 375 mg/ kg/ day.