Både CYP2D6 og CYP1A2 katalyserer dannelsen af to hovedmetabolitter: glukuronidkonjugat af 4 - hydroxy- duloxetin og sulfatkonjugat af 5- hydroxy, 6- methoxy- duloxetin.
Both CYP2D6 and CYP1A2 catalyse the formation of the two major metabolites glucuronide conjugate of 4-hydroxy duloxetine and sulphate conjugate of 5-hydroxy,6-methoxy duloxetine.