Hvis progressiv nedsat nyrefunktion forekommer, vist ved en stigende non- protein nitrogen, skal behandlingen nøje genovervejes, med overvejelser om at stoppe diretikabehandlingen.
If progressive renal impairment becomes evident, as indicated by a rising non-protein nitrogen, careful reappraisal of therapy is necessary, with consideration given to discontinuing diuretic therapy (see section 4.3).