Hos mennesker lå tigecyklins gennemsnitlige distributionsvolumen ved steady- state på 500- 700 l (7- 9 l/ kg), hvilket angiver, at tigecyklin fordeles i stort omfang ud over plasmavolumen og koncentreres i væv.
In humans, the steady-state volume of distribution of tigecycline averaged 500 to 700 L (7 to 9 L/ kg), indicating that tigecycline is extensively distributed beyond the plasma volume and concentrates into tissues.