Hos patienter med alvorlig nyreinsufficiens (creatinin clearance < 30 ml/ min) bør doser over 10 mg/ dag overvejes omhyggeligt, og om nødvendigt initieres forsigtigt.
In patients with severe renal insufficiency (creatinine clearance < 30 ml/ min), dosages above 10 mg/ day should be carefully considered and, if deemed necessary, implemented cautiously.