Derimod er der observeret overdoseringssymptomer og tegn som generel svaghed, træthed, diarré, kvalme, opkastning, hårtab, mundtørhed, hyponatriæmi, vægttab og ortostatisk hypotension efter administration af saquinavir sammen med andre proteasehæmmere.
Whereas acute or chronic overdose of saquinavir alone did not result in major complications, in combination with other protease inhibitors, overdose symptoms and signs such as general weakness, fatigue, diarrhoea, nausea, vomiting, hair loss, dry mouth, hyponatraemia, weight loss and orthostatic hypotension have been observed.