Denne sidstnævnte proces ledsages af progressiv hæmning af acetylkolinfrigørelse; kliniske symptomer er manifeste inden for 2 - 3 dage med maksimal effekt set inden for 5- 6 uger efter injektion.
This latter process is accompanied by progressive inhibition of acetylcholine release, clinical signs are manifest within 2-3 days, with peak effect seen within 5-6 weeks of injection.