På trods af en lavere affinitet for carbamoylfosfatasesyntetase overfor cargluminsyre end overfor N- acetylglutamat, har cargluminsyre in vivo vist sig at stimulere carbamoylfosfatasesyntetase og at være langt mere effektiv end N- acetylglutamat til at beskytte mod ammoniumforgiftning hos rotter.
Despite a lower affinity of carbamoyl phosphate synthetase for carglumic acid than for N-acetylglutamate, carglumic acid has been shown in vivo to stimulate carbamoyl phosphate synthetase and to be much more effective than N-acetylglutamate in protecting against ammonia intoxication in rats.