Antiretroviral kombinationsbehandling, herunder regimer indeholdende en proteasehæmmer forbindes med omfordeling af legemsfedt hos nogle patienter inkl. tab af perifert, subkutant fedt, øget intraabdominal fedt, brysthypertrofi og dorsocervikal fedtophobning ("buffalo hump").
Combination antiretroviral therapy, including regimens containing a protease inhibitor, is associated with redistribution of body fat in some patients, including loss of peripheral subcutaneous fat, increased intra-abdominal fat, breast hypertrophy and dorsocervical fat accumulation (buffalo hump).