Efter oral administration sås et fald i zidovudinclearance, som medførte en stigning i AUC i plasma for zidovudin på 35% ± 23%.
In a pharmacokinetic study co-administration of zidovudine and atovaquone tablets showed a decrease in zidovudine clearance after oral dosing leading to a 35% ± 23% increase in plasma zidovudine AUC.