Stoffer, der hæmmer CYP3A- metabolismen Stoffer såsom proteasehæmmere (indinavir, nelfinavir, ritonavir), antimykotika, (som f. eks. itraconazol, ketoconazol, voriconazol), calciumkanalblokkere (f. eks. diltiazem, verapamil), makrolid - antibiotika (f. eks. clarithromycin, erythromycin) og cimetidin, grapefrugtjuice, aprepitant, fluvoxamin og nefazodon er stærke CYP3A4- hæmmere og kan øge blodkoncentrationerne af de aktive dele, temsirolimus og dets metabolit sirolimus.
Agents inhibiting CYP3A metabolism Agents such as protease inhibitors (indinavir, nelfinavir, ritonavir), antifungals (e. g., itraconazole, ketoconazole, voriconazole), calcium channel blockers (e. g., diltiazem, verapamil), macrolide antibiotics (e. g., clarithromycin, erythromycin), and cimetidine, grapefruit juice, aprepitant, fluvoxamine and nefazodone are strong CYP3A4 inhibitors and may increase blood concentrations of the active moieties, temsirolimus and its metabolite, sirolimus.