Hos patienter med N- acetylglutamatsyntase mangel, viste cargluminsyre sig at inducere en hurtig normalisering af plasma ammoniumniveauer, sædvanligvis indenfor 24 timer.
In patients with N-acetylglutamate synthase deficiency, carglumic acid was shown to induce a rapid normalisation of plasma ammonia levels, usually within 24 hours.