Efter gentagen dosering med clopidogrel 75 mg/ dag var plasmaniveauet for den cirkulerende hovedmetabolit lavere hos forsøgspersoner med alvorlig nyresygdom (kreatininclearance 5- 15 ml/ min) sammenlignet med forsøgspersoner med moderat nyresygdom (kreatininclearance 30- 60 ml/ min) og niveauet i andre undersøgelser hos raske forsøgspersoner.
After repeated doses of 75 mg clopidogrel per day, plasma levels of the main circulating metabolite were lower in subjects with severe renal disease (creatinine clearance from 5 to 15 ml/min) compared to subjects with moderate renal disease (creatinine clearance from 30 to 60 ml/min) and to levels observed in other studies with healthy subjects.