Rotigotin inducerede ikke genmutationer i Ames- testen, men udviste in vitro i muselymfomtesten effekt med metabolisk aktivering og svagere effekt uden metabolisk aktivering.
Rotigotine did not induce gene mutations in the Ames test, but did show effects in the in vitro Mouse Lymphoma Assay with metabolic activation and weaker effects without metabolic activation.