Et farmakologisk sikkerhedsstudie med intravenøs indgift af lacosamid i bedøvede hunde viste kortvarige stigninger i PR- interval og QRS- kompleks og fald i blodtrykket, hvilket højst sandsynligt skyldes kardiodepression.
In the toxicity studies, the plasma concentrations of lacosamide obtained were similar or only marginally higher than those observed in patients, which leaves low or non-existing margins to human exposure A safety pharmacology study with intravenous administration of lacosamide in anesthetized dogs showed transient increases in PR interval and QRS complex duration and decreases in blood pressure most likely due to a cardiodepressant action.