Hos patienter med svært nedsat hepatisk funktion (Child - Pugh klassifikation C) var middelværdierne for sirolimus AUC og t½ øget med henholdsvis 210% og 170%, og CL/ F var nedsat med 67% sammenlignet med normale sunde individer.
In severe hepatically impaired patients (Child-Pugh classification C), mean values for sirolimus AUC and t1/ 2 were increased 210% and 170% respectively, and CL/ F was decreased by 67% compared to normal healthy subjects.