(Forskellen på rotigotin versus placebo 25%; CI95% 13%; 36%, forskel pramipexol versus placebo 32% CI95% 21%; 43%, forskel pramipexol versus rotigotin 7%; CI95% - 2%; 17%). Middelreduktionen i “ off ” - tid var 2, 5 timer i rotigotin- armen, 2, 8 timer i pramipexol- armen og 0, 9 timer i placebo- armen.
At the end of the maintenance treatment an improvement of at least 30% was seen in 60% of the subjects receiving rotigotine, 67% of the subjects receiving pramipexole and 35% of the subjects receiving placebo (Difference rotigotine versus placebo 25%; CI95% 13%; 36%, difference pramipexole versus placebo 32% CI95% 21%; 43%, difference pramipexole versus rotigotine 7%; CI95% -2%; 17%). The mean reduction in the “ off” time was 2.5 hours in the rotigotine arm, 2.8 hours in the pramipexole arm and 0.9 hours in the placebo arm.