Hos voksne akkumuleres fluoxetin og norfluoxetin i høj grad efter gentagne orale indgivelser – steady state- koncentrationerne blev opnået inden for 3 til 4 ugers daglig indgivelse. • Leverinsufficiens:
As in adults, fluoxetine and norfluoxetine accumulated extensively following multiple oral dosing; steady-state concentrations were achieved within 3 to 4 weeks of daily dosing. • Hepatic insufficiency: