Farmakodynamisk effekt Med abatacept sås derdosisafhængige fald i serumniveauer af opløselig interleukin- 2- receptor, en markør for T- lymfocytaktivering; serum interleukin- 6 (et produkt af aktiverede synovia- makrofager og fibroblast- lignende synoviocytter i reumatoid artritis); reumatoid faktor (et autoantistof dannet af plasmaceller) samt C- reaktivt protein (en akutfase- reaktant for inflammation).
Pharmacodynamic effects Dose-dependent reductions were observed with abatacept in serum levels of soluble interleukin-2 receptor, a marker of T lymphocyte activation; serum interleukin-6, a product of activated synovial macrophages and fibroblast-like synoviocytes in rheumatoid arthritis; rheumatoid factor, an autoantibody produced by plasma cells; and C-reactive protein, an acute phase reactant of inflammation.