Farmakokinetiske simuleringer indikerer, at den overordnede eksponering (AUC0- ∞) af 0, 25 mg intravenøst palonosetron én gang dagligt i 3 dage i træk var sammenlignelig med en enkelt iv- dosis på 0, 75 mg, selvom Cmax for 0, 75 mg enkeltdosen var højere.
Pharmacokinetic simulations indicate that the overall exposure (AUC0-∞) of 0.25 mg intravenous palonosetron administered once daily for 3 consecutive days was similar to a single intravenous dose of 0.75 mg, although Cmax of the 0.75 mg single dose was higher.