En hensigtsmæssig farmaceutisk udvikling og undersøgelser af forligeligheden mellem det aktive indholdsstof og hjælpestofferne ville på et meget tidligt stadium have afsløret tilstedeværelsen af de omhandlede to forventede urenheder, hvorved man kunne have anvendt andre metoder for at undgå, at de optræder.
An adequate pharmaceutical development and the performance of compatibility studies between the active substance and the excipients would have identified at a very early stage the presence of the referred two foreseeable impurities, and therefore another approach could have been taken in order to avoid their presence.