5 Stoffer, der inducerer CYP3A- metabolismen Samtidig indgift af TORISEL og rifampicin, en potent CYP3A4/ 5- induktor, havde ingen signifikant virkning på temsirolimus Cmax (maksimal koncentration) og AUC (arealet under koncentrations - vs. tidskurven) efter intravenøs indgift, men reducerede sirolimus Cmax med 65% og AUC med 56%, sammenlignet med TORISEL- behandling alene.
Agents inducing CYP3A metabolism Co-administration of TORISEL with rifampicin, a potent CYP3A4/ 5 inducer, had no significant effect on temsirolimus Cmax (maximum concentration) and AUC (area under the concentration vs. time curve) after intravenous administration, but decreased sirolimus Cmax by 65% and AUC by 56%, compared to TORISEL treatment alone.