Langvarig og intensiv brug af topikale kortikosteroider er kendt for at udløse lokale og systemiske effekter, inklusive nedsat binyrefunktion, atrofi af epidermis og forlænget helingstid.
Prolonged and intensive use of topical corticosteroids preparation is known to trigger local and systemic effects, including suppression of adrenal function, thinning of the epidermis and delayed healing.