Ved behandlingens afslutning (efter 6 eller 8 uger) sås en signifikant effekt af agomelatin 25- 50 mg i tre af de seks kortvarige dobbeltblinde, placebokontrollerede forsøg.
At the end of treatment (over 6 or 8 weeks), significant efficacy of agomelatine 25-50 mg was demonstrated in 3 of the six short-term double-blind placebo-controlled studies.