Antiretroviral kombinationsterapi har været forbundet med omfordeling af kropsfedt (lypodystrophy) hos HIV - patienter inklusiv tab af subkutant fedtlag i ansigtet, forøget fedtlag på mave og de indre maveorganer, forøgelse af brystfedtlag og akkumulering af ryggens fedtdepoter (tyrenakke).
Combination antiretroviral therapy has been associated with redistribution of body fat (lipodystrophy) in HIV patients including the loss of peripheral and facial subcutaneous fat, increased intra-abdominal and visceral fat, breast hypertrophy and dorsocervical fat accumulation (buffalo hump).