I et andet 3- ugers forsøg var risperidon 1- 6 mg/ dag startende med 2 mg/ dag kombineret med litium, valproat eller carbamazepin ikke bedre end litium, valproat eller carbamazepin alene med hensyn til reduktion af samlet YMRS- score.
In a second 3-week study, risperidone 1 to 6 mg/ day starting at 2 mg/ day, combined with lithium, valproate, or carbamazepine was not superior to lithium, valproate, or carbamazepine alone in the reduction of YMRS total score.