Metaboliske interaktioner anses ikke for sandsynlige, da ibandronsyre ikke hæmmer de vigtige humane lever P450 isoenzymer og inducerer ikke levercytokrom P450 systemet hos rotter.
Metabolic interactions are not considered likely, since ibandronic acid does not inhibit the major human hepatic P450 isoenzymes and has been shown not to induce the hepatic cytochrome P450 system in rats.