I toksikologiske forsøg sås plasmavolumenforøgelse med fortynding af blodet, anæmi og reversibel, excentrisk hypertrofi af hjertet, konsistent efter gentagen dosering til mus, rotter, hunde og aber.
In toxicology studies, plasma volume expansion with haemodilution, anaemia, and reversible eccentric cardiac hypertrophy was consistently apparent after repeated dosing of mice, rats, dogs, and monkeys.