Det må heller ikke anvendes til patienter med hjerteinsufficiens, leverproblemer, akut koronarsyndrom såsom ustabil angina (en svær form for brystsmerter, der varierer i intensitet) visse typer af hjertetilfælde eller diabeteskomplikationer (diabetisk ketoacidose eller diabetisk koma).
It should not be used in patients who have heart failure, problems with their liver, an ‘ acute coronary syndrome’ such as unstable angina (a severe type of chest pain that changes in intensity) or certain types of heart attack, or complications of diabetes (diabetic ketoacidosis or diabetic precoma).