I det præ - og postnatale forsøg sås en stigning i fostermortalitet ved doser, der var toksiske for moderdyret (en dosis, der svarer til en plasmaeksponering 4 gange højere end observeret hos patienter).
In the pre- and post-natal study, an increase in foetal mortality was observed at doses that were toxic to the dams (a dose corresponding to a plasma exposure level 4-fold higher than observed in patients).