Hos begge arter kan difloxacin konjugeres (glucuronideres eller sulfateres), demetyleres til sarafloxacin eller oxideres til N- oxid- difloxacin.
In both species difloxacin may be conjugated (glucuronidated or sulphated), desmethylated into sarafloxacin or oxidised into N-oxide-difloxacin.