Derimod er lamotrigins terapeutiske virkningsmekanismer ved bipolar sygdom ikke afklaret, selvom interaktion med de spændingsfølsomme natriumkanaler sandsynligvis er en vigtig faktor.
In contrast, the mechanisms by which lamotrigine exerts its therapeutic action in bipolar disorder have not been established, although interaction with voltage gated sodium channels is likely to be important.