For et behandlingsregimen med BuMel til pædiatriske patienter er det indberettet, at administration af melphalan mindre end 24 timer efter den sidste orale administration af busulfan kan påvirke udviklingen af toksiciteter.
In paediatric patients, for the BuMel regimen it has been reported that the administration of melphalan less than 24 hours after the last oral busulfan administration may influence the development of toxicities.