Det er især tilfældet, hvis det administreres mindre end 6 timer efter sidste brug af heroin eller andre kortvirkende opioider, eller hvis det administreres mindre end 24 timer efter sidste dosis metadon (se pkt.
When initiating treatment with buprenorphine, the physician must be aware of the partial agonist profile of buprenorphine and that it can precipitate withdrawal in opioid-dependent patients particularly if administered less than 6 hours after the last use of heroin or other short acting opioid, or if administered less than 24 hours after the last dose of methadone (see section 4.2).