Alvorlige allergiske reaktioner (incl. alvorlig lokal opsvulmen af huden og hiven efter vejret), lavt kombineret antal blodplader, røde og hvide blodceller, sygdomme i nervesystemet (med tegn og symptomer svarende til dissemineret sclerose eller inflammation i øjets nerver eller rygmarven), tuberkulose, forværring af hjerteinsufficiens, kramper, lupus eller lupuslignende syndrom (symptomerne kan omfatte vedvarende udslæt, feber, ledsmerte og træthed), inflammation i blodkarrene, lavt antal røde blodceller, lavt antal hvide blodceller, lavt antal neutrofiler (en type hvide blodceller), forhøjede levertal i blodet, hududslæt som kan føre til alvorlig blæredannelse og afskalning af huden.
 Rare (may occur in less than 1 in 1,000 patients): serious allergic reactions (including severe localized swelling of the skin and wheezing); combined low platelet, red, and white blood cell count; nervous system disorders (with signs and symptoms similar to those of multiple sclerosis or inflammation of the nerves of the eyes or spinal cord); tuberculosis; worsening congestive heart failure; seizures; lupus or lupus-like syndrome (symptoms may include persistent rash, fever, joint pain, and tiredness); inflammation of the blood vessels; low red blood cell count, low white blood cell count, low neutrophil (a type of white blood cell) count; elevated liver blood tests; skin rash which may lead to severe blistering and peeling of the skin..