Hjerteinsufficiens er sjældent rapporteret i markedsføringen af brugen af pioglitazon, men oftere når pioglitazon blev brugt i kombination med insulin eller på patienter med en historie om hjerteinsufficiens.
Heart failure has been reported rarely with marketing use of pioglitazone, but more frequently when pioglitazone was used in combination with insulin or in patients with a history of cardiac failure.