Hæmning af ACE resulterer i en reduktion af angiotensin II i plasmaet, som bevirker en øget plasmareninaktivitet (ved hæmning af den negative feedback fra reninfrigørelse) og reduceret sekretion af aldosteron.
Anaphylactoid reactions during low-density lipoproteins (LDL) apheresis Rarely, patients receiving ACE inhibitors during low-density lipoprotein (LDL) apheresis with dextran sulphate have experienced life-threatening anaphylactoid reactions.