I eksperimentelle modeller hos hunde er det vist, at langtidsbehandling med en aldosteron - antagonist forebygger progressiv dysfunktion af venstre ventrikel og mindsker remodelleringen af venstre ventrikel hos hunde med kronisk hjerteinsufficiens.
In experimental models in dogs, it was shown that long term therapy with an aldosterone antagonist prevents progressive left ventricle dysfunction and attenuates left ventricle remodelling in dogs with chronic heart failure.