Levodopa metaboliseres i høj grad til forskellige metabolitter, hvor decarboxylering via dopadecarboxylase (DDC) og O- methylering via cathecol- O- methyltransferase (COMT) er de vigtigste metaboliseringsveje.
Levodopa is extensively metabolised to various metabolites, decarboxylation by dopa decarboxylase (DDC) and O-methylation by catechol-O-methyltransferase (COMT) being the most important pathways.