På basis af en analyse af populationsfarmakokinetik i fase II- undersøgelser, ændrede samtidig anvendelse af dexamethason, prochlorperazin, phenytoin, carbamazepin, ondansetron, H2- receptor - antagonister eller phenobarbital ikke udskillelsen af TMZ.
Based on an analysis of population pharmacokinetics in phase II trials, co-administration of dexamethasone, prochlorperazine, phenytoin, carbamazepine, ondansetron, H2 receptor antagonists, or phenobarbital did not alter the clearance of TMZ.