Derudover inducerer mitotan en tilstand af binyrebarkinsufficiens, der leder til forsvinden af Cushings syndrom hos patienter med udskillende adrenalt carcinom og nødvendiggør substituerende hormonbehandling.
In addition, mitotane induces a state of adrenal insufficiency which leads to the disappearance of Cushing syndrome in patients with secreting adrenal carcinoma and necessitates substitution hormonotherapy.