Hos patienter, der bliver nedtrappet fra IT opiater, bør IT infusionsdosen med opiater nedsættes gradvist over en periode på nogle få uger og erstattes med en farmakologisk ækvivalent dosis af orale opiater.
For patients being withdrawn from IT opiates, the IT opiate infusion dose should be gradually tapered over a few weeks and replaced with a pharmacologically equivalent dose of oral opiates.