In vitro og in vivo blokerer losartan og dennes farmakologisk aktive carboxylsyremetabolit E- 3174 alle fysiologisk relevante virkninger af angiotensin- II, uafhængig af kilde eller syntesevej.
In vitro and in vivo losartan and its pharmacologically active carboxylic acid metabolite E-3174 block all physiologically relevant actions of angiotensin II, regardless of the source or route of its synthesis.