Forskellen mellem trough- koncentrationerne om morgenen og om eftermiddagen eller aftenen efter behandling to eller tre gange daglig blev også observeret hos raske frivillige, hos hvem dosisintervallerne var præcis 8 eller 12 timer.
The difference between morning and afternoon or evening trough concentrations for the TID and BID regimens was also observed in healthy volunteers who were dosed at precise 8- or 12-hour intervals.