I forbindelse med brugen af NSAID og nogle selektive COX- 2 hæmmere er der efter markedsføringen meget sjældent indberettet alvorlige hudreaktioner, nogle af dem fatale, inklusive exfoliativ dermatitis, Stevens- Johnson syndrom og toksisk epidermisk nekrolyse (se pkt.
Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs and some selective COX-2 inhibitors during post-marketing surveillance (see section 4.8).