Følgende anbefales derfor: • Plasma- CPK bør måles ved baseline og i regelmæssige intervaller (mindst én gang om ugen) under hele behandlingen hos alle patienter. • Det kan ikke udelukkes, at patienter, hvis CPK- værdi overstiger 5 gange den øvre grænse for normalværdi ved baseline, kan have større risiko for yderligere stigninger under behandlingen med daptomycin.
Therefore, it is recommended that: • Plasma CPK should be measured at baseline and at regular intervals (at least once weekly) during therapy in all patients. • It cannot be ruled out that those patients with CPK greater than 5 times upper limit of normal at baseline may be at increased risk of further increases during daptomycin therapy.