Vedvarende aktivering af PDGF receptoren eller Abl protein tyrosin kinase, der opstår på grund af en fusion med andre proteiner eller konstitutiv produktion af PDGF er blevet impliceret i patogenesen af MDS/ MPD, HES/ CEL og DFSP.
Constitutive activation of the PDGF receptor or the Abl protein tyrosine kinases as a consequence of fusion to diverse partner proteins or constitutive production of PDGF have been implicated in the pathogenesis of MDS/ MPD, HES/ CEL and DFSP.