To hidtil ukendte bindingstedsmutationer i et konserveret område blev identificeret i HBV- polymerasegenet (rtN236T og rtA181V) og medførte klinisk adefovirdipivoxilresistens.
Two novel conserved site mutations were identified in the HBV polymerase gene (rtN236T and rtA181V), which conferred clinical resistance to adefovir dipivoxil.