Tilstedeværelsen af den rumlige bicycloaminsubstituent i position C- 7 forhindrer aktiv udstrømning forbundet med nor- A - eller pmr- A - generne set i visse grampositive bakterier.
The presence of the bulky bicycloamine substituent at the C-7 position prevents active efflux, associated with the norA or pmrA genes seen in certain Gram-positive bacteria.