Biotransformation Der er fundet 7 hovedmetabolitter og de metaboliske veje er vist at være glukoronidering ved pyridin - nitrogenatomet, pyridin- N- oxidation med og uden 3 ’ - hydroxylering på indanringen, 3 ’ - hydroxylering af indan, p- hydroxylering af phenylmethylgruppen, og N- depyridomethylering med og uden 3 ’ - hydroxylering.
Biotransformation Seven major metabolites were identified and the metabolic pathways were identified as glucuronidation at the pyridine nitrogen, pyridine– N– oxidation with and without 3’– hydroxylation on the indane ring, 3’– hydroxylation of indane, p– hydroxylation of phenylmethyl moiety, and N– depyridomethylation with and without the 3’– hydroxylation.