Øgede plasmakoncentrationer af paroxetin ses hos patienter med svært nedsat nyrefunktion (kreatininclearance under 30 ml/ min.) og hos patienter med nedsat leverfunktion.
• Renal/ hepatic impairment Increased plasma concentrations of paroxetine occur in patients with severe renal impairment (creatinine clearance less than 30 ml/ min) or in those with hepatic impairment.