Hos individer med svær nyreinsufficiens (CrCl < 30 ml/ min) sås en 3- foldig stigning i plasmakoncentration og en 9- foldig stigning i koncentrationen af N- desmethyl metabolitten sammenlignet med raske frivillige.
Subjects with severe impairment (CrCl < 30 ml/ min) had a 3-fold increase in plasma concentration and a 9-fold increase in the N-desmethyl metabolite concentration compared to healthy volunteers.