4. 3 og 4. 4), patienter som ikke forventedes at overleve i 28 dage på grund af eksisterende, ikke- sepsis relaterede medicinske forhold, HIV- positive patienter, hvis seneste CD4 tal var ≤ 50/ mm3, patienter i kronisk dialyse, patienter, som havde fået foretaget knoglemarvs -, lunge -, lever -, pankreas - eller tyndtarmstransplantation, og patienter med akut klinisk pankreatitis uden kendt infektionskilde.
Exclusion criteria encompassed patients at high risk of bleeding (see sections 4.3 and 4.4), patients who were not expected to survive for 28 days due to a pre-existing, non-sepsis related medical condition, HIV positive patients whose most recent CD4 count was ≤ 50/ mm3, patients on chronic dialysis, and patients who had undergone bone marrow, lung, liver, pancreas or small bowel transplantation, and patients with acute clinical pancreatitis without a proven source of infection.