Herudover inducerede irbesartan hyperplasi/ hypertrofi af de juxtaglomerulære celler (hos rotter ved ≥ 90 mg/ kg/ dag, hos marekatte ved ≥ 10 mg/ kg/ dag).
Furthermore, irbesartan induced hyperplasia/ hypertrophy of the juxtaglomerular cells (in rats at ≥ 90 mg/ kg/ day, in macaques at ≥ 10 mg/ kg/ day).