Hvis serumkreatinin under kombinationsbehandling overstiger 1, 5 mg/ dl anbefales det at konsultere den eksisterende information for cisplatin vedrørende dosisreduktion/ fortsat behandling.
If, during topotecan/ cisplatin combination therapy serum creatinine exceeds 1.5 mg/ dL, it is recommended that the full prescribing information be consulted for any advice on cisplatin dose reduction/ continuation.