Selvom der ikke har været foretaget nogle kliniske studier for at evaluere Enbrel behandling af patienter med multipel sclerose, har kliniske studier af andre TNF antagonister hos patienter med multipel sclerose vist forøgelse i sygdomsaktiviteten.
Although no clinical trials have been performed evaluating Enbrel therapy in patients with multiple sclerosis, clinical trials of other TNF antagonists in patients with multiple sclerosis have shown increases in disease activity.