Da paclitaxel metaboliseres af cytochrome P450 isoenzymerne CYP 3A4 og 2C8, bør anden medicin, der hæmmer (f. eks. erythromycin, fluoxetin, gemfibrozil, imidazol svampedræbende midler) eller inducerer (f. eks. rifampicin, carbamazepin, phenytoin, fenobarbital, efavirenz, nevirapin) disse enzymer, anvendes med forsigtighed, da de eventuelt kan påvirke paclitaxels farmakokinetik.
Since paclitaxel is metabolised by cytochrome P450 isoenzymes CYP 3A4 and 2C8, caution should be exercised with other drugs known to inhibit (e. g. erythromycin, fluoxetine, gemfibrozil, imidazole antifungals) or induce (e. g. rifampicin, carbamazepine, phenytoin, phenobarbital, efavirenz, nevirapine) these enzymes as they may affect the pharmacokinetics of paclitaxel.