Anamnese med svært hovedtraume, som har krævet hospitalsindlæggelse, intrakraniel eller intraspinal operation, hæmoragisk apopleksi indenfor de seneste 3 måneder, enhver intracerebral arteriovenøs misdannelse, cerebral aneurisme eller solid svulst i centralnervesystemet eller patienter der har epiduralkateter eller som forventes at få lagt epiduralkateter under infusionen.
history of severe head trauma that required hospitalization, intracranial or intraspinal surgery, or haemorrhagic stroke within the previous 3 months, or any history of intracerebral arteriovenous malformation, cerebral aneurysm, or central nervous system mass lesion; patients with an epidural catheter or who are anticipated to receive an epidural catheter during drug infusion