COX 1 er et bredt distribueret konstitutivt enzym, som primært står for opretholdelse af organ - og vævsfunktioner, mens COX- 2 induceres, hvor der sker vævsskade, men i nogle organer er det også konstitutivt.
COX-1 is a widely distributed constitutive enzyme, primarily involved in maintaining organ and tissue function, whilst COX-2 is inducible at sites of tissue damage but in some organs it is also constitutive.