Resultater fra to store kliniske studier har vist, at kvinder, som anvendte en anden type østrogen/ gestagen- kombination end Activelle, havde en let øget risiko for hjertesygdomme i det første behandlingsår.
Results from two clinical studies showed that women, who used another type of oestrogen/progestagen combination than the one in Activelle, had a slightly increased risk of cardiovascular disease in the first year of use.