Mange cytotoksiske lægemidler – direkte eller indirekte DNA- syntesehæmmere – medfører makrocytose (hydroxycarbamid, cytarabin, mercaptopurin, thioguanin).
Many cytotoxic medicinal products – direct or indirect DNA synthesis inhibitors – lead to macrocytosis (hydroxycarbamide, cytarabine, mecaptopurine, thioguanine).