Der er stadig begrænset erfaring med samtidig administration af entakapon og en række lægemidler, herunder MAO- A- inhibitorer, tricykliske antidepressiva, noradrenalin re- uptake hæmmere såsom desipramin, maprotilin og venlafaxin samt lægemidler, som metaboliseres af COMT (f. eks. katechol- strukturforbindelser: rimiterol, isoprenalin, adrenalin, noradrenalin, dopamin, dobutamin, alfa- methyldopa, apomorphin og paroxetin).
However, the experience of the clinical use of entacapone with several medicinal products, including MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine, maprotiline and venlafaxine, and medicinal products that are metabolised by COMT (e. g. catechol- structured compounds: rimiterol, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa, apomorphine, and paroxetine) is still limited.