I enkelt- dosis infusions hundestudier, administreret over 15 minutter, var 1, 0 mg/ kg (6 gange den anbefalede humane terapeutiske eksponering baseret på AUC) fint tolereret uden nyreproblemer.
In the single-dose dog infusion studies, 1.0 mg/ kg (6 fold the recommended human therapeutic exposure based on AUC) administered over 15 minutes was well tolerated with no renal effects.