Plasmaprøver fra sibutramin- behandlede forsøgspersoner udviste signifikant hæmning af såvel noradrenalingenoptag (73%) som serotoningenoptag (54%) og ingen signifikant hæmning af dopamingenoptag (16%).
There are a number of reports of overdose in humans (including accidental ingestion by children as young as 18 months) where doses of up to 500 mg sibutramine hydrochloride monohydrate were ingested.