Hvis det antages, at indehaveren af markedsføringstilladelsen peger på noget videnskabeligt holdbart, og et metoden altså burde have omfattet et ekstra oprensningstrin for at forbedre genfindingen, består argumentets svaghed i, at alle prøveresultaterne dermed skulle være for lave.
Assuming the MAH has a valid scientific point, and thus the method should have included an additional clean-up step to improve recovery, the weakness of this argument was that all sample results could therefore be understated.