I et 26- ugers, kontrolleret, dobbeltblindt, multinationalt forsøg med olanzapin til behandling af skizofreni, som inkluderede 314 patienter, og hvor det primære endpoint var vægtstigning, fandtes signifikant færre patienter at have 7% eller yderligere vægtstigning i forhold til baseline (dvs en stigning på mindst 5, 6 kg for en middel- baselinevægt på ∼80, 5 kg) med aripripazol (N= 18 eller 13% af de evaluérbare patienter) sammenlignet med olanzapin (N= 45 eller 33% af de evaluérbare patienter).
In a 26-week, olanzapine-controlled, double-blind, multi-national study of schizophrenia which included 314 patients and where the primary end-point was weight gain, significantly less patients had at least 7% weight gain over baseline (i. e. a gain of at least 5.6 kg for a mean baseline weight of ~80.5 kg) on aripiprazole (N = 18, or 13% of evaluable patients), compared to olanzapine (N = 45, or 33% of evaluable patients).