Farmakokinetisk/ farmakodynamisk (PK/ PD) sammenhæng Analyse af PK/ PD- forholdet har vist, at hjertefrekvensen falder næsten lineært med stigende plasmakoncentrationer af ivabradin og S 18982 i doser op til 15- 20 mg to gange daglig.
Pharmacokinetic/ pharmacodynamic (PK/ PD) relationship PK/ PD relationship analysis has shown that heart rate decreases almost linearly with increasing ivabradine and S 18982 plasma concentrations for doses of up to 15-20 mg twice daily.