Knoglemarvsfibrose er en kendt komplikation ved kronisk nyreinsufficiens hos mennesker, der kan relateres til sekundær hyperparathyroidisme eller ukendte faktorer.
In some preclinical toxicological studies in dogs and rats, but not in monkeys, epoetin alfa therapy was associated with subclinical bone marrow fibrosis (bone marrow fibrosis is a known complication of chronic renal failure in humans and may be related to secondary hyperparathyroidism or unknown factors.