En forøget serotonerg effekt såsom serotoninsyndrom kan forekomme ved samtidig brug af et SSRI- præparat og præparater indeholdende perikum (Hypericum perforatum).
An increase in serotonergic effects, such as serotonin syndrome, may occur when selective serotonin reuptake inhibitors and herbal preparations containing St John’ s Wort (Hypericum perforatum) are used together.