Ved cellekultur viste krydsresistensprofiler for efavirenz, nevirapin og delavirdin, at K103N- substitutionen giver tab af følsomhed over for alle tre NNRTI´ere.
Cross resistance: cross resistance profiles for efavirenz, nevirapine and delavirdine in cell culture demonstrated that the K103N substitution confers loss of susceptibility to all three NNRTIs.