På lus og lopper griber Imidacloprid ind i funktionen af visse specifikke receptorer (nikotinerge acetylkolinreceptorer) i nervesystemet, så parasitterne lammes og dør.
Imidacloprid interferes with certain specific receptors (nicotinergic acetylcholine receptors) in the nervous systems of lice and fleas, which results in their subsequent paralysis and death.