Desuden blev den seneste EU- vejledning for vurdering af farmakokinetikken for lægemidler hos patienter med nedsat nyrefunktion først fastlagt i 1994 (Note for Guidance on the evaluation on the pharmacokinetics of medicinal products in patients with impaired renal function, CHMP/ EWP/ 225/ 02).
In addition, the most recent EU Guideline was only established in 1994 (Note for Guidance on the evaluation on the pharmacokinetics of medicinal products in patients with impaired renal function, CHMP/ EWP/ 225/ 02).