Gentagen administration af darunavir til rotter forårsagede induktion af mikrosomale enzymer i leveren og øgede eliminationen af skjoldbruskkirtelhormoner, som prædisponerer rotter, men ikke mennesker, for neoplasmer i skjoldbruskkirtlen.
Repeated administration of darunavir to rats caused hepatic microsomal enzyme induction and increased thyroid hormone elimination, which predispose rats, but not humans, to thyroid neoplasms.