Hos aber viste indgivelse af DuoTrav to gange daglig sig at påføre øget palpebral fissur og øge irispigmentationen tilsvarende det, der observeredes ved okulær indgivelse af prostanoider.
In monkeys, administration of DuoTrav twice– daily was shown to induce increased palpebral fissure and to increase iris pigmentation similar to that observed with ocular administration of prostanoids.