Hæmmere af CYP 1A2 (f. eks. coffein, diclofac, diazepam, nicergolin, clomepramin, imipramin, fluvoxamin, phenacetin, theophyllin, amitriptylin, og quinoloner) kan potentielt nedsætte riluzoles eliminations- hastighed, hvorimod stoffer, der fremmer CYP 1A2 (f. eks. cigaretrygning, grillmad, rifampicin og omeprazol) kan øge eliminationshastigheden af riluzole.
Inhibitors of CYP 1A2 (e. g. caffeine, diclofenac, diazepam, nicergoline, clomipramine, imipramine, fluvoxamine, phenacetin, theophylline, amitriptyline and quinolones) could potentially decrease the rate of riluzole elimination, while inducers of CYP 1A2 (e. g. cigarette smoke, charcoal-broiled food, rifampicin and omeprazole) could increase the rate of riluzole elimination.