ACOMPLIA bør heller ikke anvendes til patienter med svær depression, eller som behandles med antidepressive midler, da det kan øge risikoen for depression, herunder selvmordstanker hos et mindre antal patienter.
It must also not be used in patients with ongoing major depression or who are being treated with antidepressants, since it can increase the risk of lon depression, including thoughts about suicide in a small minority of patients.