Som et resultat af denne handlingsmekanisme udviser ciprofloxacin ikke krydsresistens med andre vigtige, kemisk forskellige grupper af stoffer, som f. eks. beta- laktam antibiotika, aminoglycosider, tetracycliner, makrolider og polypeptider, sulfonamider, trimethoprim og nitrofurantoin.
As a result of its mechanism of action, ciprofloxacin does not show cross-resistance with other important, chemically different groups of substances such as beta-lactam antibiotics, aminoglycosides, tetracyclines, macrolides and polypeptides, sulphonamides, trimethoprim and nitrofurantoine.