Karcinogenese, mutagenese, nedsat fertilitet Hos hanrotter blev der kun fundet en statistisk signifikant stigning i urinblæretumorer (transitiocellulær- papillom og - karcinom) i forbindelse med xanthin- blæresten i højdosisgruppen ved cirka 11 gange den humane eksponering.
Carcinogenesis, mutagenesis, impairment of fertility In male rats, a statistically significant increase in urinary bladder tumours (transitional cell papilloma and carcinoma) was found only in association with xanthine calculi in the high dose group, at approximately 11 times human exposure.