Forsøg in vitro tydede på, at dannelsen af lamotrigins primære metabolit, 2- N- glukuronid, blev hæmmet minimalt ved samtidig inkubation med amitriptylin, bupropion, clonazepam, haloperidol eller lorazepam.
In vitro experiments indicated that the formation of lamotrigine's primary metabolite, the 2-N-glucuronide, was minimally inhibited by co-incubation with amitriptyline, bupropion, clonazepam, haloperidol or lorazepam.