Hos stabile patienter, som overføres fra Prograf (to gange daglig) til Advagraf (en gang daglig) i forholdet 1: 1 (mg: mg) total daglig dosis, var den systemiske eksponering for tacrolimus (AUC0- 24) for
In stable patients converted from Prograf (twice daily) to Advagraf (once daily) on a 1:1 (mg: mg) total daily dose basis the systemic exposure to tacrolimus (AUC0-24) for Advagraf was approximately 10% lower than that for Prograf.