Patienter, hvis HIV- 1 udtrykte 3 eller flere thymidin- analog- forbundne mutationer (TAMs), som omfattede enten M41L - eller L210W- revers transkriptasemutation, udviste reduceret følsomhed over for tenofovirdisoproxilfumarat.
Patients with HIV-1 expressing three or more thymidine analogue associated mutations (TAMs) that included either the M41L or L210W reverse transcriptase mutation showed reduced susceptibility to tenofovir disoproxil fumarate.