Fremstillingsprocessen for ReFacto AF er blevet modificeret for at eliminere alle exogene, humant eller animalsk afledte proteiner i celledyrkningsprocessen, oprensningen og den endelige formulering, og samtidig er navnet ændret til ReFacto AF.
The manufacturing process for ReFacto has been modified to eliminate exogenous human- or animal- derived protein in the cell culture process, purification, or final formulation; and at the same time the invented name has been changed to ReFacto AF.