To undersøgelser af Orwell og Ringe viste, at alendronat i forhold til placebo eller alfacalcidol medfører lavere incidens af vertebrale frakturer hos mænd med osteoporose.
Two studies from Orwell and Ringe demonstrated that compared respectively with placebo or alfacalcidol, alendronate treatment reduced the incidence of vertebral fractures in men with osteoporosis.