For at undgå mulig forekomst af skadelig, klinisk forværring, der skyldes potentiel rebound - effekt, bør gradvis nedsættelse af dosis (halvering af dosis i 3 til 7 dage) dog overvejes.
However, to avoid the possible occurrence of harmful clinical deterioration due to potential rebound effect, gradual dose reduction (halving the dose for 3 to 7 days) should be considered.