Samtidig administration af bosentan 500 mg to gange dagligt i 7 dage reducerede AUC, Cmax og Cmin af digoxin med henholdsvis 12%, 9% of 23%.
Digoxin: co-administration of bosentan 500 mg twice daily for 7 days decreased the AUC, Cmax and Cmin of digoxin by 12%, 9% and 23%, respectively.