Forsøget omfattede 19, 394 patienter, som fik behandlingen i 6 uger indenfor 24 timer efter et akut myokardieinfarkt.
In the GISSI-3 trial, which used a 2x2 factorial design to compare the effects of Zestril and glyceryl trinitrate given alone or in combination for 6 weeks versus control in 19,394, patients who were administered the treatment within 24 hours of an acute myocardial infarction, Zestril produced a statistically significant risk reduction in mortality of 11% versus control (2p=0.03).