Forøgelser af leveraminotransferaser, dvs. aspartat - og alaninaminotransferaser (ASAT og/ eller ALAT) i forbindelse med bosentan er dosisafhængige.
Elevations in liver aminotransferases, i.e., aspartate and alanine aminotransferases (AST and/or ALT), associated with bosentan are dose dependent.