Efavirenz er en nonkompetitiv hæmmer af HIV- 1 revers transkriptase (RT) og hæmmer ikke signifikant human immundeficient virus- 2 (HIV- 2) RT eller cellulære deoxyribonukleinsyre (DNA) polymeraser (α, β, γ eller δ).
Efavirenz non-competitively inhibits HIV-1 reverse transcriptase (RT) and does not significantly inhibit human immunodeficiency virus-2 (HIV-2) RT or cellular deoxyribonucleic acid (DNA) polymerases (α, β, γ, and δ).