Samtidig behandling med nefrotoksiske lægemidler (f. eks. aminoglycosid, loop - diuretika, platinforbindelser, cyclosporin) kan resultere i forsinket clearance af pemetrexed.
Concomitant administration of nephrotoxic drugs (e. g. aminoglycoside, loop diuretics, platinum compounds, cyclosporin) could potentially result in delayed clearance of pemetrexed.