4 Sapropterin bør anvendes med forsigtighed i patienter i samtidig behandling med levodopa, da kombinationsbehandling med sapropterin kan forårsage nedsat krampetærskel.
4 Sapropterin should be used with caution in patients who are receiving concomitant levodopa, as combined treatment with sapropterin may cause increased excitability and irritability.