Disse transskriptionsfaktorer regulerer tumorernes evne til at tilpasse sig hypoksiske mikromiljøer og til at producere den angiogene faktor, vaskulær endotelial vækstfaktor (VEGF).
These transcription factors regulate the ability of tumours to adapt to hypoxic microenvironments and to produce the angiogenic factor vascular endothelial growth factor (VEGF).