Protopic var betydeligt mere effektivt end nogen af de to hydrocortisonpræparater til at forbedre resultaterne i score- systemet, men fremkaldte i højere grad en brændende fornemmelse på huden end hydrocortison.
Protopic was significantly more effective than either of the 2 hydrocortisone preparations at producing improvements in the modified Eczema Area and Severity Index, although it also produced more burning than hydrocortisone.