Hos transplanterede patienter har langvarig systemisk eksponering af kraftig immunsuppression som følge af systemisk indgift af calcineurinhæmmere givet anledning til øget risiko for udvikling af lymfomer og maligne hudlidelser.
In transplant patients, prolonged systemic exposure to intense immunosuppression following systemic administration of calcineurin inhibitors has been associated with an increased risk of developing lymphomas and skin malignancies.