4. 5), som vil kunne påvirke virkningen af antiretrovitral behandling, bør disse patienter monitoreres omhyggeligt med hensyn til kontrol af deres HIV- infektion.
Due to the potential for such interactions especially related to the inducing effect of bosentan on CYP450 (see section 4.5), which could affect the efficacy of antiretroviral therapy, these patients should be monitored carefully regarding control of their HIV infection.