Samtidig anvendelse af APTIVUS givet sammen med lavdosis ritonavir og proteasehæmmerne amprenavir, lopinavir eller saquinavir (hver i sær indgivet med lavdosis ritonavir) i en dobbelt boostet behandling resulterer i signifikante fald i plasmakoncentrationer af disse proteasehæmmere.
Concomitant use of APTIVUS, co-administered with low dose ritonavir, with the protease inhibitors amprenavir, lopinavir or saquinavir (each co-administered with low dose ritonavir) in a dual-boosted regimen, results in significant decreases in plasma concentrations of these protease inhibitors.