HPV 16 og HPV 18 antages at være ansvarlige for cirka 70% af tilfældene af cancer i livmoderhalsen, 80% af tilfældene af adenocarcinoma in situ (AIS), 45- 70% af tilfældene af high- grade cervikal intraepithelial neoplasi (CIN 2/ 3), 25% af tilfældene af low- grade cervikal intraepithelial neoplasi (CIN 1), cirka 70% af tilfældene af HPV- relaterede high- grade intraepitheliale neoplasier i vulva (VIN 2/ 3) og intraepitheliale neoplasier i vagina (VaIN 2/ 3).
HPV 16 and HPV 18 are estimated to be responsible for approximately 70% of cervical cancers; 80% of adenocarcinoma in situ (AIS); 45-70% of high-grade cervical intraepithelial neoplasia (CIN 2/ 3); 25% of low grade cervical intraepithelial neoplasia (CIN 1); approximately 70% of HPV related high- grade vulvar (VIN 2/ 3) and vaginal (VaIN 2/ 3) intraepithelial neoplasia.