Metabolitterne M1 (demetyleret) og M- 23 (hydroxyleret) udgør de to metaboliske pathways, hvor M- 1- dannelse katalyseres af cytochrom P450 CYP2C8, og CYP3A4 og M- 23 alene katalyseres af CYP2C8.
Metabolites M-1 (demethylated) and metabolite M-23 (hydroxylated) represent the two metabolic pathways with M-1 formation catalysed by cytochrome P450 CYP2C8 and CYP3A4 and M-23 catalysed by CYP2C8 alone.