9 Zonisamid metaboliseres primært af CYP3A4 via en reduktiv spaltning af benzisoxazolringen i moderstoffet, så der dannes 2- sulphamoylacetylphenol (SMAP) samt også ved N- acetylering.
Zonisamide is metabolised primarily through reductive cleavage of the benzisoxazole ring of the parent drug by CYP3A4 to form 2-sulphamoylacetylphenol (SMAP) and also by N-acetylation.