Selvom warfarin induceret hudnekrose kan forekomme hos enhver patient i løbet af initieringen af oral antikoagulationsbehandling, har personer med medfødt protein C mangel specielt høj risiko (Se pkt.
Although Warfarin-induced skin necrosis can occur in any patient during the initiation of oral anticoagulant therapy, individuals with congenital protein C deficiency are particularly at risk.