En PK- analyse i befolkningen vurderede, at samtidig behandling med andre enzym - inducerende antiepileptiske lægemidler (carbamazepin, phenytoin, phenobarbital i forskellige doser) nedsatte lacosamids samlede systemiske indvirkning med 25%.
A population PK analysis estimated that concomitant treatment with other anti-epileptic drugs known to be enzyme inducers (carbamazepine, phenytoin, phenobarbital, in various doses) decreased the overall systemic exposure of lacosamide by 25%.