Samtidig administration af sorafenib og midazolam, dextrometorfan eller omeprazol, som er substrater for cytokrom CYP3A4, CYP2D6 og CYP2C919, henholdsvis, forandrede ikke eksponeringen af disse substanser.
Concomitant administration of sorafenib and midazolam, dextromethorphan or omeprazole, which are substrates for cytochromes CYP3A4, CYP2D6 and CYP2C19 respectively, did not alter the exposure of these agents.