Dette kan, i tilfælde af reduceret leverfunktion, føre til leverdekompensation med risiko for dødeligt udfald.
Resistance to adefovir dipivoxil (see section 5.1) can result in viral load rebound which may result in exacerbation of hepatitis B and, in the setting of diminished hepatic function, lead to liver decompensation and possible fatal outcome.