Glimepirid hæmmer leverens glukosedannelse ved at øge den intracellulære koncentration af fruktose- 2, 6 - biphosphat, som hæmmer glukoneogenesen.
Glimepiride inhibits the hepatic glucose production by increasing the intracellular concentration of fructose-2,6 bisphosphate, which in turn inhibits gluconeogenesis.