Nedregulering med en gonadotropin- frigivende hormon (GnRH) - agonist eller antagonist er nu almindeligt anvendt for at hæmme den endogene LH- stigning og for at kontrollere LH- niveauerne.
Down-regulation with a gonadotrophin-releasing hormone (GnRH) agonist or antagonist is now commonly used in order to suppress the endogenous LH surge and to control tonic levels of LH.