For at mindske risikoen for opioidrelaterede bivirkninger og fastlægge den "effektive" dosis er det af største vigtighed, at patienten nøje overvåges af uddannet sundhedspersonale under titreringsprocessen.
In order to minimise the risks of opioid-related undesirable effects and to identify the effective dose, it is imperative that patients be monitored closely by health professionals during the titration process.