Dosisanbefalingerne til patienter med nedsat nyrefunktion, med øget dosisinterval, forventes at resultere i højere peak - plasmakoncentrationer og lavere Cmin niveauer hos patienter med nedsat nyrefunktion sammenlignet med patienter med normal nyrefunktion.
The dosing recommendations in patients with renal impairment, with increased dosing interval, are expected to result in higher peak plasma concentrations and lower Cmin levels in patients with renal impairment compared with patients with normal renal function.