47 Der er indberettet nefrogen systemisk fibrose (NSF) i forbindelse med anvendelse af visse gadolinium - holdige kontrastmidler hos patienter med alvorlig nyreinsufficiens (GFR < 30 ml/ min/ 1, 73 m2) og patienter som har eller skal have levertransplantation.
Precautions are necessary when examining these patients (e. g. monitoring of the patient) and the equipment and medicinal products needed for the rapid treatment of possible convulsions should be available.  Renal impairment and liver transplant patients There have been reports of nephrogenic systemic fibrosis (NSF) associated with use of some gadolinium-containing contrast agents in patients with severe renal impairment (GFR < 30ml/ min/ 1.73m2), and in those who have had or are undergoing liver transplantation.