Tilfælde af bronkial anastomose insufficiens, oftest fatal, er rapporteret hos de novo lungetransplanterede patienter, hvor sirolimus er brugt som del af en immunosuppressiv behandling.
Cases of bronchial anastomotic dehiscence, most fatal, have been reported in de novo lung transplant patients when sirolimus has been used as part of an immunosuppressive regimen.