På grund af aprepitants inducerende virkning på CYP3A4 kan AUC for methylprednisolon, ved kontinuerlig administration af methylprednisolon, mindskes i op til 2 uger efter behandlingsstart med EMEND.
During continuous treatment with methylprednisolone, the AUC of methylprednisolone may decrease at later time points within 2 weeks following initiation of dosing with EMEND, due to the inducing effect of aprepitant on CYP3A4.