Patienter, hvis sygdom var forårsaget af et virus, der er resistent (ikke reagerer) over for lamivudin (et andet antiretroviralt lægemiddel) bør ikke anvende Hepsera alene, men bør tage det sammen med lamivudin.
Patients whose disease is caused by a virus that is resistant (does not respond) to lamivudine (another antiviral medicine) should not take Hepsera on its own, but should take it in combination with lamivudine.