Hos cancerpatienter, der blev behandlet med primært intravenøse bisphosphonater, er der rapporter om osteonekrose af kæben, generelt forbundet med tandudtrækning og/ eller lokal infektion (herunder osteomyelitis).
Osteonecrosis of the jaw, generally associated with tooth extraction and/ or local infection (including osteomyelitis) has been reported in patients with cancer receiving treatment regimens including primarily intravenously administered bisphosphonates.