Det er vist in vivo, at Kaletra inducerer sin egen metabolisme samt øger biotransformationen af visse lægemidler, som metaboliseres ved hjælp af cytocrom P450 enzymer og ved glucuronidering.
Kaletra has been shown in vivo to induce its own metabolism and to increase the biotransformation of some medicinal products metabolised by cytochrome P450 enzymes and by glucuronidation.