2, 4x for buprenorphin ved en human dosis på 24 mg Suboxone baseret på AUC, plasmaniveauer for naloxon var under grænsen for detektion i rotter) havde ingen utilsigtet virkning på fertiliteten hos hunner.
A dietary dose of 100 ppm (estimated exposure approximately 2.4x for buprenorphine at a human dose of 24 mg Suboxone based on AUC, plasma levels of naloxone were below the limit of detection in rats) had no adverse effect on fertility in females.