Der er fremsat hypotese om, at denne øgede transendotheliale transport formidles af gp- 60 albumin receptoren, og at der er akkumulering af paclitaxel i tumorområdet på grund af det albumin- bindende protein SPARC (secerneret surt cysteinrigt protein).
It is hypothesised that this enhanced transendothelial transport is mediated by the gp-60 albumin receptor, and that there is accumulation of paclitaxel in the area of tumour due to the albumin-binding protein SPARC (secreted protein acidic rich in cysteine).