Flerdosistoksicitetsstudier i rotter og hunde bekræftede disse ovenfor nævnte observationer, men studievarigheden var begrænset til 2 uger af antistofdannelse til det humane protein tenecteplase, hvilket resulterede i anafylaksi.
Multiple-dose toxicity studies in rats and dogs confirmed these above-mentioned observations, but the study duration was limited to two weeks by antibody formation to the human protein tenecteplase, which resulted in anaphylaxis.