Hos patienter med reumatoid artrit sås ingen farmakokinetiske interaktioner mellem leflunomid (10 - 20 mg daglig) og methotrexate (10- 25 mg ugentlig).
In patients with rheumatoid arthritis, no pharmacokinetic interaction between the leflunomide (10 to 20 mg per day) and methotrexate (10 to 25 mg per week) was demonstrated.