Det anbefales, at første dose af calciumfolinat på 15 mg (6- 12 mg/ m2) gives over12- 24 timer (maximalt 24 timer) efter opstart af methotrexatinfusion.
As a rule, the first dose of calcium folinate is 15 mg (6-12 mg/ m²) to be given 12-24 hours (24 hours at the latest) after the beginning of methotrexate infusion.