Metaboliske interaktioner anses ikke for sandsynlige, da ibandronsyre ikke hæmmer de primære humane lever P450 isoenzymer og har vist sig ikke at inducere levercytokrom P450 systemet hos rotter.
Metabolic interactions are not considered likely, since ibandronic acid does not inhibit the major human hepatic P450 isoenzymes and has been shown not to induce the hepatic cytochrome P450 system in rats.