Udvikling af YMDD- variant HBV er associeret med reduceret behandlingsrespons hos nogle patienter, som viser sig ved øgede HBV DNA niveauer og forhøjelse af ALAT fra tidligere terapiniveauer, progression af tegn og symptomer på hepatitis sygdom og/ eller forværring af hepatiske nekroinflammatoriske fund.
Development of YMDD variant HBV is associated with reduced treatment response in some patients, as evidenced by increased HBV DNA levels and ALT elevations from previous on-therapy levels, progression of signs and symptoms of hepatitis disease and/ or worsening of hepatic necroinflammatory findings.