Tilfælde af interstitiel lungesygdom (herunder pneumonitis og sjældent bronchiolit og pulmonal fibrose), nogle dødelige, uden identificeret smitsom ætiologi er opstået hos patienter, som fik immunosupressive behandlinger, herunder Rapamune.
Cases of interstitial lung disease (including pneumonitis and infrequently bronchiolitis obliterans organising pneumonia (BOOP) and pulmonary fibrosis), some fatal, with no identified infectious etiology have occurred in patients receiving immunosuppressive regimens including Rapamune.