67 gange den dosis, der er anbefalet til humant brug (baseret på AUC), sås hos fostrene en øget forekomst af anoftalmi/ microftalmi, bølgeformede ribben og føtale forandringer.
In an embryotoxicity study rat foetuses of dams given greater than approximately 67 times the recommended human dose (based on AUC) had increasing incidences of anophthalmia/ microphthalmia, wavy ribs and foetal alterations.