Det er blevet vist, at rufinamid inducerer cytokrom P450 enzymet CYP3A4 Rufinamid kan derfor reducere plasmakoncentrationerne af lægemidler, der metaboliseres af dette enzym.
Rufinamide has been shown to induce the cytochrome P450 enzyme CYP3A4 and may therefore reduce the plasma concentrations of drugs which are metabolised by this enzyme.