Da abacavir øger den hastighed, hvormed metadon udskilles fra kroppen, vil patienter der tager metadon, blive undersøgt for abstinenssymptomer, og skal måske have ændret deres metadondosis.
As abacavir increases the rate at which methadone is removed from the body, patients taking methadone will be checked for any withdrawal symptoms, and may have their methadone dose changed.