Ved terapeutiske koncentrationer hæmmer febuxostat ikke andre enzymer, der medvirker i purin - eller pyrimidin- metabolismen, dvs. guanin- deaminase, hypoxanthin- guanin - fosforibosyltransferase, orotat- fosforibosyltransferase, orotidin monofosfat- decarboxylase eller purin nukleosid fosforylase.
At therapeutic concentrations febuxostat does not inhibit other enzymes involved in purine or pyrimidine metabolism, namely, guanine deaminase, hypoxanthine guanine phosphoribosyltransferase, orotate phosphoribosyltransferase, orotidine monophosphate decarboxylase or purine nucleoside phosphorylase.