Moderate og svage CYP3A4 hæmmere kan nedsætte metaboliseringen af sirolimus og øge sirolimusniveauet (f. eks. kalcium- blokkere: verapamil; antisvampemidler: clotrimazol, fluconazol; antibiotika: troleandomycin; andre stoffer: bromocriptin, cimetidin, danazol, protease- hæmmere).
39 the results cannot exclude the possibility of changes in the pharmacokinetics that might affect the efficacy of the oral contraceptive during long term treatment with Rapamune.