Hos patienter med alvorlig nyreinsufficiens faldt AUC0- ∞ for total- aprepitant (ubunden og proteinbundet) med 21% og Cmax faldt med 32%, set i forhold til raske personer.
In patients with severe renal impairment, the AUC0-∞ of total aprepitant (unbound and protein bound) decreased by 21% and Cmax decreased by 32%, relative to healthy subjects.