Hæmning af mTOR- aktiviteten medfører en G1- vækststandsning i de behandlede tumorceller som resultat af et selektivt sammenbrud i translationen af regulerende proteiner, der regulerer cellecyklus som f. eks D- type cycliner, c- myc og ornithindecarboxylase.
Inhibition of mTOR activity results in a G1 growth arrest in treated tumour cells resulting from selective disruption of translation of cell cycle regulatory proteins, such as D-type cyclins, c-myc, and ornithine decarboxylase.