Som resultat af virkningemekanismen viser ciprofloxacin ikke krydsresistens med andre vigtige kemisk forskellige grupper af stoffer, som betalaktamantibiotika, aminoglykosider, tetracykliner, makrolider, og polypeptider, sulfonamider, trimetoprim og nitrofurantoin.
As a result of its mechanism of action, ciprofloxacin does not show cross-resistance with other important, chemically different groups of substances such as beta-lactam antibiotics, aminoglycosides, tetracyclines, macrolides and polypeptides, sulphonamides, trimethoprim and nitrofurantoine.