Til sammenligning viste samtidig administration af methadon og amprenavir i en historisk ikke - matched kontrolgruppe en nedsættelse af serum amprenavir AUC, Cmax og Cmin med henholdsvis 30%, 27% og 25%.
As compared to a non-matched historical control group, co-administration of methadone and amprenavir resulted in a 30%, 27% and 25% decrease in serum amprenavir AUC, Cmax and Cmin respectively.