Udskillelsen af stoffer metaboliseret af cytokrom P450 3A4 (f. eks. kønssteroider, kortikosteroider, antikonvulsiva og cyclosporin) kan blive forøget, hvilket kan give lavere plasmaniveauer for disse stoffer.
The clearance of compounds metabolised by cytochrome P 450 3A4 (e. g. sex steroids, corticosteroids, anticonvulsants and cyclosporine) may be especially increased resulting in lower plasma levels of these compounds.