På grund af voldsom diurese medfører overdosis af hydrochlorthiazid elektrolyt- depletion (hypokaliæmi, hypochloræmi, hyponatriæmi) og dehydrering.
Overdose with hydrochlorothiazide is associated with electrolyte depletion (hypokalaemia, hypochloremia, hyponatraemia) and dehydration resulting from excessive diuresis.