Desuden er der rapporteret to alvorlige bivirkninger i kliniske undersøgelser vedrørende postoperativ kvalme og opkastning (PONV) hos patienter, der tog en højere dosis aprepitant:
In addition, two serious adverse reactions were reported in clinical studies in postoperative nausea and vomiting (PONV) in patients taking a higher dose of aprepitant: one case of constipation, and one case of sub-ileus.