I et forsøg med rotter ved en systemisk eksponering, der er mindst 15 gange den forventede humane dosis, blev der rapporteret cholangiocarcinom (2/ 60 hanner ved 900 mg/ kg) og cholangiom (1/ 60 hunner ved 500 mg/ kg).
In addition, cholangiocarcinomas (2/ 60 males at 900 mg/ kg) and cholangioma (1/ 60 females at 500 mg/ kg) were reported in the rat study at a systemic exposure at least 15-times the expected free human exposure.