Anvendelse af Rapinyl frarådes til patienter, der har fået monoaminooxidase (MAO) - hæmmere inden for 14 dage, fordi alvorlig og uforudsigelig potensering af MAO- hæmmere er rapporteret i forbindelse med opioide analgetika.
Rapinyl is not recommended for use in patients who have received monoamine oxidase (MAO) inhibitors within 14 days because severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.