Et farmakokinetisk studie med raske forsøgspersoner, hvor en enkelt dosis trazodon blev givet sammen med lavdosis ritonavir (200 mg 2 gange dagligt), viste øget plasmakoncentration af trazodon (AUC steg 2, 4 gange).
In a pharmacokinetic study performed in healthy volunteers, concomitant use of low dose ritonavir (200 mg twice daily) with a single dose of trazodone led to an increased plasma concentration of trazodone (AUC increased by 2.4 fold).