Samtidig behandling med APTIVUS plus lavdosis ritonavir og aktive substanser, der nedbrydes via CYP3A, og hvor forhøjede plasmakoncentrationer medfører alvorlige og/ eller livstruende hændelser, er kontraindiceret.
Co-administration of APTIVUS with low dose ritonavir, with active substances that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/ or life-threatening events is contraindicated.