Hos patienter med reumatoid artrit havde celecoxib ingen signifikant virkning på farmakokinetikken (plasma - eller renal clearance) af methotrexat (i reumatologiske doser).
5 In patients with rheumatoid arthritis celecoxib had no statistically significant effect on the pharmacokinetics (plasma or renal clearance) of methotrexate (in rheumatologic doses).