Glimepirid hæmmer leverens glukosedannelse ved at øge intracellulær koncentration af fruktose- 2, 6 - biphosphat, som igen hæmmer glukoneogenesen.
Glimepiride inhibits the glucose production in the liver by increasing the intracellular concentration of fructose-2,6-bisphosphate, which in turn inhibits the gluconeogenesis.