Genetiske og farmakologiske undersøgelser med dyremodeller har vist tegn på, at PGD2, der virker gennem DP1, en af de to receptorer for PGD2, spiller en vigtig rolle i nicotinsyreinduceret flushing.
Genetic and pharmacologic studies in animal models have provided evidence that PGD2, acting through DP1, one of the two receptors for PGD2, plays a key role in nicotinic acid-induced flushing.