Denne hæmning af HIV proteasen bevirker at enzymet bliver ude af stand til at danne gag- pol polyprotein- precursor hvorved der dannes HIV partikler med umoden morfologi, der er ude af stand til at starte en ny omgang infektion.
Inhibition of HIV protease renders the enzyme incapable of processing the gag-pol polyprotein precursor which leads to the production of HIV particles with immature morphology that are unable to initiate new rounds of infection.