• Aktiv indre blødning • Patienter med intrakraniel patologi; neoplasme eller tegn på cerebral brok • Samtidig heparin behandling ≥ 15 Internationale Enheder/ kg/ time • Kendt blødningsdiatese undtagen akut koagulopati forbundet med sepsis • Kronisk svær leversygdom • Trombocyttal < 30. 000 x 106/ l, selvom trombocyttallet øges ved transfusioner • Patienter med øget risiko for blødning (for eksempel):
• Active internal bleeding • Patients with intracranial pathology; neoplasm or evidence of cerebral herniation • Concurrent heparin therapy ≥ 15 International Units/ kg/ hr • Known bleeding diathesis except for acute coagulopathy related to sepsis • Chronic severe hepatic disease • Platelet count < 30,000 x 106/ l, even if the platelet count is increased after transfusions • Patients at increased risk for bleeding (for example):