Et intermediat fra fremstillingsprocessen, som også findes i den endelige lægemiddelsubstans (< 0, 15%), var positiv for mutagenese i en in vitro test på bakterieceller (Ames test).
One intermediate in the manufacturing process, which is also present in the final drug substance (< 0.15%), was positive for mutagenesis in an in vitro bacterial cell assay (Ames test).