En undersøgelse i hunde viste, at skeletal myopati blev reduceret efter én gang daglig administration sammenlignet med delte doseringer med samme totale dagsdosis, hvilket indikerer, at myopati- effekter i dyr primært er relateret til tid mellem dosis.
A study in dogs demonstrated that skeletal myopathy was reduced upon once daily administration as compared to fractionated dosing at same total daily dose, suggesting that myopathic effects in animals were primarily related to time between doses.