Docetaxel fandtes ydermere at være aktivt over for nogle, men ikke alle cellelinjer, der udviste overekspression af p- glycoprotein, hvis tilstedeværelse er bestemt af "multidrug resistance" - genet (MDR- genet).
In addition, docetaxel was found to be active on some but not all cell lines over expressing the p-glycoprotein which is encoded by the multidrug resistance gene.