Da piroxicam har vist sig at være forbundet med stor risiko for gastrointestinale komplikationer, bør kombinationsbehandling med slimhindebeskyttende midler (f. eks. misoprostol eller protonpumpehæmmere) overvejes, især til ældre patienter. ”
Given that piroxicam has been shown to be associated with an increased risk of gastrointestinal complications, the possible need for combination therapy with gastro-protective agents (e. g. misoprostol or proton pump inhibitors) should be carefully considered, in particular for elderly patients .”