Stigninger i serumalaninaminotransferase (ALAT) sås i alle hundeundersøgelserne ved systemisk eksponering, der var mindst 14 gange eksponeringen hos mennesker på basis af AUC for den anbefalede daglige dosis til mennesker.
Increases in serum alanine aminotransferase (ALT) levels were observed in all dog studies, at systemic exposure levels at least 14 times the human exposure based on the AUC of the recommended daily human dose.