Ved doser > 6 mg/ kg, sås hos rotter i 13- ugers undersøgelsen hyperplasi af det transitoriske epithel i nyrepapillerne og i urinblæren, uden ændringer i serum - eller urinparametre.
In rats, hyperplasia of the transitional epithelium in the renal papilla and in the urinary bladder was observed at doses ≥ 6 mg/ kg in the 13-week study, without changes in serum or urinary parameters.