Kardiotoksicitet kan også forekomme ved kumulative antracyclindoser mindre end 450 mg/ m2 hos patienter med forudgående mediastinal strålebehandling eller hos patienter i samtidig cyclophosphamidbehandling.
Cardiac toxicity also may occur at cumulative anthracycline doses lower than 450 mg/ m2 in patients with prior mediastinal irradiation or in those receiving concurrent cyclophosphamide therapy.