Selv om paliperidon er en kraftig D2- antagonist, som menes at lindre skizofreniens positive symptomer, medfører stoffet mindre katalepsi og nedsætter de motoriske funktioner i mindre grad end traditionelle neuroleptika.
Even though paliperidone is a strong D2-antagonist, which is believed to relieve the positive symptoms of schizophrenia, it causes less catalepsy and decreases motor functions to a lesser extent than traditional neuroleptics.