Efter seponering af trimetrexat gives calciumfolinat 40mg/ m² i. v. hver 6. time i 3 dage.
• Overdosage (possibly occurring with trimetrexate doses above 90 mg/ m2 without concomitant administration of calcium folinate): after stopping trimetrexate, calcium folinate 40 mg/ m2 IV every 6 hours for 3 days.