Generelt anbefales det, at udbedre dehydrering, hypovolæmi eller saltmangel før behandlingen påbegyndes (dog bør sådanne korrigerende handlinger nøje vurderes mod risikoen for volumenoverbelastning hos patienter med hjerteinsufficiens).
Generally, it is recommended to correct dehydration, hypovolaemia or salt depletion before initiating treatment (in patients with heart failure, however, such corrective action must be carefully weighed out against the risk of volume overload).