Forudgående eksponering for cytotoksiske midler Hos patienter, som tidligere har fået omfattende myelosuppressiv behandling efterfulgt af administration af filgrastim for at mobilisere perifere blodstamceller, vil disse blodlegemer muligvis ikke mobiliseres i tilstrækkelig grad til at opnå den anbefalede minimumshøst (≥ 2, 0 x 106 CD34+ celler/ kg) eller gendannelsen af trombocytter ikke fremskyndes i samme grad.
Prior exposure to cytotoxic agents Patients who have undergone very extensive prior myelosuppressive therapy, followed by administration of filgrastim for mobilisation of PBPCs, may not show sufficient mobilisation of these blood cells to achieve the recommended minimum yield (≥ 2.0 x 106 CD34+ cells/ kg) or acceleration of platelet recovery to the same degree.