Derudover var den langsigtede (4 til 5 år) udvikling af resistens over for adefovirdipivoxil signifikant lavere hos patienter, der havde serum- HBV- DNA under grænsen for kvantificering (< 1. 000 kopier/ ml ved uge 48) sammenlignet med patienter, der havde serum - HBV- DNA på over 1. 000 kopier/ ml ved uge 48.
In addition, the long-term (4 to 5 years) development of resistance to adefovir dipivoxil was significantly lower in patients who had serum HBV DNA below the limit of quantification (< 1,000 copies/ ml) at week 48 as compared to patients with serum HBV DNA above 1,000 copies/ ml at week 48.