Den LDL- reducerende effekt af simvastatin kan involvere både reduktion af VLDL- kolesterolkoncentration og induktion af LDL- receptoren, medførende reduceret produktion og øget katabolisme af LDL- kolesterol.
The mechanism of the LDL-lowering effect of simvastatin may involve both reduction of VLDL cholesterol concentration and induction of the LDL receptor, leading to reduced production and increased catabolism of LDL cholesterol.