Forsøg med mennesker og in vitro- forsøg, hvor der anvendes humane levermikrosomer og udtrykte enzymer viste, at maraviroc fortrinsvis metaboliseres af cytochrom P450- systemet til metabolitter, der er essentielt inaktive over for HIV- 1.
Metabolism: studies in humans and in vitro studies using human liver microsomes and expressed enzymes have demonstrated that maraviroc is principally metabolized by the cytochrome P450 system