I hunrotter, som fik exenatid i 2 år, sås en øget incidens af godartede thyreoide C−celle adenomer ved den højeste dosis, 250 µg/ kg/ dag, en dosis, som gav en exenatid plasmaeksponering på 130 gange den humane kliniske eksponering.
In female rats given exenatide for 2 years, an increased incidence of benign thyroid C− cell adenomas was observed at the highest dose, 250 µg/ kg/ day, a dose that produced an exenatide plasma exposure 130-fold the human clinical exposure.