400 mg imatinib to gange daglig havde en inhibitorisk effekt på CYP2D6- medieret metoprololmetabolisme, som gav en stigning af Cmax og AUC for metoprolol på cirka 23% (90% CI [1, 16- 1, 30]).
Imatinib at 400 mg twice daily had an inhibitory effect on CYP2D6-mediated metoprolol metabolism, with metoprolol Cmax and AUC being increased by approximately 23% (90%CI [1.16-1.30]).