En øget viden om de økologiske virkninger af langvarig indtagelse af doxycyclin i lave doser, er dog ønskelig, og ansøgeren anmodes om at forpligte sig til at indsende en studieprotokol for et veltilrettelagt postmarketingsstudie, der undersøger fremkomsten af resistens i relevante bakteriegrupper i tarmsystemet og de øvre luftveje til vurdering og efterfølgende at udføre undersøgelsen inden for 3 måneder efter godkendelsen.
However, increased knowledge of the ecological effects of long-term administration of low-dose doxycycline is highly desirable, and the Applicant is requested to commit to submitting a study protocol for a well designed post-marketing clinical study investigating emergence of resistance in relevant bacterial groups in the intestinal and upper respiratory tract for validation and to carry out a study accordingly within 3 months of approval.