Der fandtes i en 39- ugers undersøgelse med aber ingen NOAEL (no observed adverse effect level/ niveau ved ingen observeret bivirkningseffekt) ved den laveste dosis på 15 mg/ kg, ca.
In a 39-week monkey study, no NOAEL (no observed adverse effect level) was established at the lowest dose of 15 mg/ kg, approximately one-third the maximum human dose of 800 mg based on body surface.