Som ved andre opioider skal der udvises forsigtighed ved brug af buprenorphin hos patienter med læsioner i hovedet, øget intrakranielt tryk, hypotension, prostata hypertrofi eller uretral stenose.
As with other opioids, caution is requested in patients using buprenorphine and having head injury, increased intracranial pressure, hypotension, prostatic hypertrophy or urethral stenosis.