Amlodipin udøver antianginal virkning ved dilatation af perifere arterioler samt via reduktion af det kardielle afterload uden, at det medfører refleks- takykardi, og følgelig energiforbrug og iltbehov ved kardiel muskelrelaksation.
Amlodipine exerts antianginal effect through the dilation of peripheral arterioles as well as through reduction of cardiac afterload, without resulting in reflex tachycardia, and accordingly, energy consumption and oxygen demand of cardiac muscle decrease.