Patienter, der tidligere er blevet eller sideløbende bliver behandlet med intratekal kemoterapi eller tidligere har modtaget kraniospinal strålebehandling, har potentielt øget risiko for neurologiske bivirkninger (se pkt.
Patients treated previously or concurrently with intrathecal chemotherapy or previously with craniospinal irradiation are potentially at increased risk for neurological adverse events (see section 4.2