Som følge af risikoen for forlænget sedering, anbefales det at dosisjustering bør overvejes, når posaconazol gives samtidig med ethvert benzodiazepin, der metaboliseres af CYP3A4 (f. eks. midazolam, triazolam, alprazolam).
Due to the risk of prolonged sedation it is recommended that dose adjustments should be considered when posaconazole is administered concomitantly with any benzodiazepine that is metabolised by CYP3A4 (e. g. midazolam, triazolam, alprazolam).