Fostermisdannelser i forbindelse med udsættelse for isotretinoin inkluderer abnormiteter i centralnervesystemet (hydrocephalus, misdannelse af cerebellum/ cerebellare abnormiteter, microcephalus), facial dysmorphia, ganespalte, misdannelse af ydre øre (manglende ydre øre, lille eller manglende ydre øregange), øjenabnormiteter (microphthalmia), kardiovaskulære misdannelser (konotrunkale misdannelser såsom Fallot tetralogi, ombytning af de store kar, septumdefekter), misdannelse af thymus og parathymus.
The foetal malformations associated with exposure to isotretinoin include central nervous system abnormalities (hydrocephalus, cerebellar malformation/ abnormalities, microcephaly), facial dysmorphia, cleft palate, external ear abnormalities (absence of external ear, small or absent external auditory canals), eye abnormalities (microphthalmia), cardiovascular abnormalities (conotruncal malformations such as tetralogy of Fallot, transposition of great vessels, septal defects), thymus gland abnormality and parathyroid gland abnormalities.