Dette indbefattede: dosisafhængig binyretoksicitet (lipofuscin pigmentakkumulering og/ eller parenkymalt celletab) hos rotter efter 104 uger med 20- 60 mg/ kg/ dag (3- 10 gange middel- steady- state AUC ved den maksimale, anbefalede humane dosis) samt øget forekomst af binyrekarcinomer og kombinerede binyreadenomer/ karcinomer hos hunrotter ved 60 mg/ kg/ dag (10 gange middel- steady- state AUC ved den maksimale, anbefalede humane dosis).
These included: dose-dependent adrenocortical toxicity (lipofuscin pigment accumulation and/ or parenchymal cell loss) in rats after 104 weeks at 20 to 60 mg/ kg/ day (3 to 10 times the mean steady-state AUC at the maximum recommended human dose) and increased adrenocortical carcinomas and combined adrenocortical adenomas/ carcinomas in female rats at 60 mg/ kg/ day (10 times the mean steady-state AUC at the maximum recommended human dose).