Førende eksperter på området understreger i dag af vigtigheden af at anvende en fluorquinolon- dosering, der medfører højere in vivo- koncentrationer end den mutationshæmmende koncentration for at undgå first- step mutanter.
The importance of using dosage regimens of fluoroquinolones leading to in vivo concentrations exceeding the mutant prevention concentrations, thus avoiding first-step mutants, is currently stressed by leading experts within the field.