Knoglenekrose i kæben, normalt ledsaget af tandudtrækning og/ eller lokal infektion (herunder osteomyelitis) er rapporteret hos cancerpatienter, der får behandlingsregimer herunder primært intravenøst administrerede bisphosphonater.
Osteonecrosis of the jaw, generally associated with tooth extraction and/ or local infection (including osteomyelitis) has been reported in patients with cancer receiving treatment regimens including primarily intravenously administered bisphosphonates.