Øget alanin aminotransferase i de første tre måneder efter påbegyndt behandling med rizulol; det var oftest forbigående og niveauet vendte tilbage til under dobbelt ULN efter 2 til 6 måneder ved fortsat behandling.
Increased alanine aminotransferase usually appeared within 3 months after the start of therapy with riluzole; they were usually transient and levels returned to below twice the ULN after 2 to 6 months while treatment was continued.