Det afslapper den glatte muskulatur i karrene ved at binde sig til hæm- delen af cytosolguanylatcyclase, idet det aktiverer guanylatcyclase og forøger de intracellulære koncentrationer af cyklisk guanosin 3 ’, 5 ’ - monophosphat, som så medfører vasodilatation.
It relaxes vascular smooth muscle by binding to the haeme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3’ ,5’ -monophosphate, which then leads to vasodilation.