In vitro- undersøgelser med humane levermikrosomer indikerer, at cytokrom P450 3A4, 2A6 og 2C9 er involverede i metaboliseringen af montelukast.
In vitro studies using human liver microsomes indicate that cytochrome P450 3A4, 2A6 and 2C9 are involved in the metabolism of montelukast.