42 kan muligvis forklares ved de højere koncentrationer af α1- syre glycoprotein (AAG) hos HIV- 1 - inficerede patienter, hvilket resulterer i højere binding af darunavir til plasma- AAG og derfor i højere plasmakoncentrationer.
The increased exposure to darunavir in HIV-1 infected patients compared to healthy subjects may be explained by the higher concentrations of alpha-1-acid glycoprotein (AAG) in HIV-1 infected patients, resulting in higher darunavir binding to plasma AAG and, therefore, higher plasma concentrations.