In vitro har ambrisentan ingen hæmmende effekt på P- glycoprotein (Pgp) - medieret effluks af digoxin, og det er et svagt substrat for Pgp- medieret effluks.
In vitro, ambrisentan has no inhibitory effect on the P-glycoprotein (Pgp)-mediated efflux of digoxin and is a weak substrate for Pgp-mediated efflux.