Store mængder grapefrugtjuice (mere end 1, 2 l dagligt i 5 dage) øger atorvastatins AUC med 2, 5 gange og AUC af den aktive (atorvastatin og metabolitter) HMG- CoA- reduktasehæmmere med 1, 3 gange.
However, large quantities of grapefruit juice (over 1.2 l daily for 5 days) increased AUC of atorvastatin 2.5 fold and AUC of active (atorvastatin and metabolites) HMG-CoA reductase inhibitors 1.3 fold.