På trods af dette er Irbesartan Winthrop uden risiko blevet administreret sammen med andre antihypertensive stoffer som beta- blokkere, langtidsvirkende calcium- antagonister samt diuretika af thiazidtypen.
Diuretics and other antihypertensive agents: other antihypertensive agents may increase the hypotensive effects of irbesartan; however Irbesartan Winthrop has been safely administered with other antihypertensive agents, such as beta-blockers, long-acting calcium channel blockers, and thiazide diuretics.