På grund af hydrochlorthiazid- komponenten anbefales Karvezide ikke til patienter med alvorlig nyreinsufficiens (kreatininclearance < 30 ml/ min).
Renal impairment: due to the hydrochlorothiazide component, Karvezide is not recommended for patients with severe renal dysfunction (creatinine clearance < 30 ml/ min).