Nedsat leverfunktion Hos patienter med let eller moderat leverinsufficiens (Child Pugh B) steg Cmax og AUC for den aktive metabolit henholdsvis 1, 4 og 2, 1 gange sammenlignet med raske forsøgspersoner.
Hepatic impairment In patients with moderate hepatic impairment (Child Pugh B), Cmax and AUC of the active metabolite increased 1.4 and 2.1-fold, respectively, as compared to healthy subjects.