Patienter med stærkt aktiveret renin- angiotensin- aldosteron system (f. eks. renovaskulær hypertension, salt og/ eller volumendepletering, hjerteinsufficiens eller alvorlig hypertension) kan opleve et kraftigt blodtryksfald efter initialdosis.
Patients with a strongly activated renin-angiotensin-aldosterone system (e. g., renovascular hypertension, salt and/ or volume depletion, cardiac decompensation, or severe hypertension) may experience an excessive blood pressure fall following the initial dose.