Der er indberettet forekomst af lactacidose (uden hypoxæmi), i nogle tilfælde fatal, sædvanligvis forbundet med svær hepatomegali og leversteatosis, ved brug af nukleosidanaloger.
Lactic acidosis and severe hepatomegaly with steatosis: occurrences of lactic acidosis (in the absence of hypoxaemia), sometimes fatal, usually associated with severe hepatomegaly and hepatic steatosis, have been reported with the use of nucleoside analogues.