Når angiotensin II- antagonister administreres samtidig med nonsteroide antiinflammatoriske lægemidler (fx selektive COX- 2 hæmmere, acetylsalicylsyre (> 3 g/ dag) og nonselektive NSAID) kan den antihypertensive virkning svækkes.
Non-steroidal anti-inflammatory drugs: when angiotensin II antagonists are administered simultaneously with non-steroidal anti-inflammatory drugs (i. e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/ day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.