Dog kan det på grund af farmakokinetiske ændringer forventes, at nogle patienter, som får denne kombination, udvikler abstinenssymptomer og behøver en højere methadondosis.
None of the subjects experienced withdrawal symptoms in this study; however, due to the pharmacokinetic changes, it should be expected that some patients who received this drug combination may experience withdrawal symptoms and require an upward adjustment of the methadone dose.