15 clearance er 91, 8 ml/ min, og halveringstiden i plasma er 3, 5 timer hos patienter med normal nyre - funktion (kreatinin- clearance på 90 ml/ min).
Pemetrexed total systemic clearance is 91.8 ml/ min and the elimination half-life from plasma is 3.5 hours in patients with normal renal function (creatinine clearance of 90 ml/ min).