In vitro- data har vist, at ved terapeutiske koncentrationer hæmmer ambrisentan hverken UGT1A1, UGT1A6, UGT1A9, UGT2B7 eller cytokrom- P450- enzymerne 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 og 3A4.
In vitro data have shown that at therapeutic concentrations, ambrisentan does not inhibit UGT1A1, UGT1A6, UGT1A9, UGT2B7 or cytochrome P450 enzymes 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4.