Ved kontinuerlig behandling med methylprednisolon kan AUC for methylprednisolonforbigående blive nedsat i op til 2 uger efter behandlingsstart med peroral aprepitant, hvilket skyldes aprepitants sene inducerende virkning på CYP3A4.
During continuous treatment with methylprednisolone, the AUC of methylprednisolone may decrease at later time points within 2 weeks following initiation of dosing with oral aprepitant, due to the inducing effect of aprepitant on CYP3A4.