Der er set biliær hyperplasi hos cynomolgusaber, der havde fået efavirenz i ≥ 1 år i en dosis, der resulterede i middel- AUC- værdier ca.
Biliary hyperplasia was observed in cynomolgus monkeys given efavirenz for ≥ 1 year at a dose resulting in mean AUC values approximately 2-fold greater than those in humans given the recommended dose.