Det kan ikke udelukkes, at sorafenib kan øge koncentrationerne af samtidig administrerede substrater af CYP2C8 (f. eks. bupropion, cyclophosphamid, efavirenz, ifosfamid, methadon) og CYP2C8 (f. eks paclitaxel, amodiaquin, repaglinid).
It cannot be excluded that sorafenib may increase the concentrations of concomitantly administered substrates of CYP2B6 (e. g. bupropion, cyclophosphamide, efavirenz, ifosfamide, methadone) and CYP2C8 (e. g. paclitaxel, amodiaquine, repaglinide).