Clopidogrel hæmmer selektivt, at adenosindiphosphat (ADP) bindes til dets trombocytreceptor og som følge deraf, at ADP aktiverer GBIIb- IIIa- komplekset og derved hæmmer clopidogrel trombocytaggregation.
Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, and the subsequent ADP-mediated activation of the GPIIb/ IIIa complex, thereby inhibiting platelet aggregation.