Mutationer af KRAS- genet ved visse hotspots (primært codon 12 og 13) resulterer i konstitutiv aktivering af KRAS- proteinet uafhængigt af EGFR- signalering.
Mutations of the KRAS gene at certain hot-spots (mainly codons 12 and 13) result in constitutive activation of the KRAS protein independently of EGFR signalling.