Det forbedrer ikke den homocystein- sænkende effekt at øge antallet af doseringer til mere end to gange dagligt og/ eller at øge dosis til mere end 150 mg/ kg/ dag.
In paediatric patients less than 3 years of age, the usual effective dose regimen is 100 mg/ kg/ day given in 2 doses daily; increasing the frequency above twice daily and/ or the dose above 150 mg/ kg/ day does not improve the homocysteine-lowering effect.