Sildenafils metabolisme finder overvejende sted via cytokrom P450 (CYP) isoformer 3A4 (primær vej) og 2C9 (sekundær vej).
Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route).