Alvorlige og i nogle tilfælde fatale reaktioner er rapporteret for patienter, der indtager et SSRI- præparat i kombination med en MAO- hæmmer, samt for patienter, der for nylig har stoppet SSRI- behandling og påbegyndt behandling med en MAO- hæmmer.
Cases of serious and sometimes fatal reactions have been reported in patients receiving an SSRI in combination with a monoamine oxidase inhibitor (MAOI), and in patients who have recently discontinued an SSRI and have been started on a MAOI.