Svær primær IGFD defineres ved: • højde standardafvigelse score ≤ – 3, 0 og • basale IGF- 1- niveauer under 2, 5 percentilen for alder og køn og • GH- sufficiens • Eksklusion af sekundære former for IGF- 1- mangel, såsom fejlernæring, hypotyroidisme, eller kronisk behandling med farmakologiske doser af antiinflammatoriske steroider.
Severe Primary IGFD is defined by: • height standard deviation score ≤ – 3.0 and • basal IGF-1 levels below the 2.5th percentile for age and gender and • GH sufficiency. • Exclusion of secondary forms of IGF-1 deficiency, such as malnutrition, hypothyroidism, or chronic treatment with pharmacologic doses of anti-inflammatory steroids.