Sammenlignet med calcium kanal hæmmeren, som gav en blodtrykssænkning i samme størrelsesorden, sås et signifikant større fald i urinalbuminudskillelseshastighed for Zestril, hvilket giver evidens for at Zestrils ACE - hæmmende effekt reducerede mikroalbuminuri ved en direkte effekt på nyrevævet ud over dets blodsænkende effekt.
When compared with the calcium channel blocker, which produced a similar reduction in blood pressure, those treated with Zestril showed a significantly greater reduction in urinary albumin excretion rate, providing evidence that the ACE inhibitory action of Zestril reduced microalbuminuria by a direct mechanism on renal tissues in addition to its blood pressure lowering effect.