16 reducerede biotilgængeligheden (AUC) af doxycyclin fra ORACEA med cirka 20% og reducerede peak plasmaniveauet med 43%.
Coadministration with a high-fat, high-protein meal that included dairy products reduced the bioavailability (AUC) of doxycycline from ORACEA by about 20% and reduced the peak plasma level by 43%.