Clomipramin absorberes godt (> 80%) fra mavetarmkanalen i hunde, når det administreres oralt, men den systemiske biotilgængelighed af clomipramin og desmethylclomipramin er 22- 26% på grund af omfattende first pass metabolisme i leveren.
Clomipramine is well absorbed (> 80%) from the gastrointestinal tract in dogs when administered orally but the systemic bioavailability for clomipramine and desmethylclomipramine is 22-26% due to extensive first pass metabolism by the liver.