I karcinogenicitetsforsøg inducerede agomelatin en stigning i incidensen af levertumorer hos rotter og mus ved en dosis, der var mindst 110 gange højere end den terapeutiske dosis.
In carcinogenicity studies agomelatine induced an increase in the incidence of liver tumours in the rat and the mouse, at a dose at least 110-fold higher than the therapeutic dose.