Administration af enten deoxycorticosteron eller NSAID sammen med spironolactone kan føre til en moderat reduktion af den spironolactons natriuretiske effekt (reduktion af natriumudskillelse i urinen).
The administration of either deoxycorticosterone or NSAIDs with spironolactone may lead to a moderate reduction of the natriuretic effects (reduction of urinary sodium excretion) of spironolactone.