53- 641- fold ændring i EC50- værdier [FC]) fra 9 HIV- 1 stammer, der indeholdt multiple PI- resistensassocierede mutationer (RAM) viste, at der krævedes mindst 8 darunavirmutationer, der blev selekteret in vitro, i HIV- 1 proteasen for at gøre en virus resistent (FC > 10) over for darunavir.
53-641-fold change in EC50 values [FC]) from 9 HIV-1 strains harbouring multiple PI Resistance-Associated Mutations (RAMs) showed that a minimum of 8 darunavir in vitro selected mutations were required in the HIV-1 protease to render a virus resistant (FC > 10) to darunavir.