5 Der blev ikke observeret nogen klinisk signifikante farmakokinetiske eller farmakodynamiske interaktioner, når rivaroxaban blev givet samtidigt med midazolam (substrat af CYP3A4), digoxin (substrat af P- gp) eller atorvastatin (substrat af CYP3A4 og P- gp), ranitidin (H2- receptorantagonist) eller antacidet aluminiumhydroxid/ magnesiumhydroxid.
Other concomitant therapies No clinically significant pharmacokinetic or pharmacodynamic interactions were observed when rivaroxaban was co-administered with midazolam (substrate of CYP3A4), digoxin (substrate of P-gp) or atorvastatin (substrate of CYP3A4 and P-gp).