COX- 2 menes også at være involveret i ovulation, implantation og lukningen af ductus arteriosus samt centralnervøse funktioner (induktion af feber, smerteopfattelse og kognitiv funktion).
COX-2 is also thought to be involved in ovulation, implantation and closure of the ductus arteriosus, and central nervous system functions (fever induction, pain perception and cognitive function).