Langvarig eksponering over for thiazider i 3. trimester af graviditeten kan reducere moderens plasmamængde samt den uteroplacentale blodstrøm, hvilket kan forårsage føto- placental iskæmi og væksthæmning.
Prolonged exposure to thiazides during the third trimester of pregnancy can reduce maternal plasma volume as well as uteroplacental blood flow, which may cause a foeto-placental ischaemia and growth retardation.