Entecavir, en guanosinnukleosidanalog med aktivitet mod HBV- polymerase, fosforyleres effektivt til den aktive trifosfat- form (TP), som har en intracellulær halveringstid på 15 timer.
Mechanism of action: entecavir, a guanosine nucleoside analogue with activity against HBV polymerase, is efficiently phosphorylated to the active triphosphate (TP) form, which has an intracellular half-life of 15 hours.