Pravastatin er en kompetitiv inhibitor af 3- hydroxy- 3- methylglutaryl- coenzyme A (HMG- CoA) reduktase, som er det enzym, der katalyserer det tidlige rate- begrænsende trin i kolesterol biosyntesen og som afstedkommer den lipidsænkende virkning på to måder.
Pravastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase, the enzyme catalysing the early rate-limiting step in cholesterol biosynthesis, and produces its lipid- lowering effect in two ways.