Clearance af lasofoxifen kan være øget hos patienter i kronisk behandling med inducere af CYP3A4 og UGT- enzymer (f. eks. phenytoin, carbamazepin, barbiturater og perikum), hvilket vil resultere i lavere steady state- koncentrationer og potentielt nedsat effekt.
Lasofoxifene clearance may be increased in patients chronically treated with inducers of CYP3A4 and UGTs (eg, phenytoin, carbamazepine, barbiturates and St John’ s Wort) resulting in reduced steady-state concentrations and may result in reduced efficacy.