Da pregabalin ikke undergår signifikant metabolisme og hovedsageligt udskilles som uomdannet lægemiddelstof i urinen, anses det ikke for sandsynligt, at nedsat leverfunktion signifikant vil ændre pregabalins plasmakoncentrationer.
Since pregabalin does not undergo significant metabolism and is excreted predominantly as unchanged drug in the urine, impaired liver function would not be expected to significantly alter pregabalin plasma concentrations.