I et åbent, randomiseret studie fik 399 tidligere ubehandlede, ældre patienter (60 – 80 år) med diffust storcellet B- celle lymfom standard- CHOP kemoterapi (cyklophosphamid 750 mg/ m2, doxorubicin 50 mg/ m2, vinkristin 1, 4 mg/ m2 op til maksimalt 2 mg på dag 1 og prednison 40 mg/ m2 på dag 1- 5) hver 3. uge i otte serier eller MabThera 375 mg/ m2 plus CHOP (R- CHOP).
In a randomised, open-label trial, a total of 399 previously untreated elderly patients (age 60 to 80 years) with diffuse large B cell lymphoma received standard CHOP chemotherapy (cyclophosphamide 750 mg/ m2, doxorubicin 50 mg/ m2, vincristine 1.4 mg/ m2 up to a maximum of 2 mg on day 1, and prednisolone 40 mg/ m2/ day on days 1-5) every 3 weeks for eight cycles, or MabThera 375 mg/ m2 plus CHOP (R-CHOP).