Ændringer i lymfeorganer hos alle testede arter, transaminaseforandringer, vakuolation af thyroidea og pancreas, katarakter, nefropati og myokardieændringer hos rotter.
Further effects seen in animals at doses that result in exposure levels similar to or moderately higher than the clinical exposure level were: changes in lymphoid organs in all species tested, transaminase changes, vacuolation of thyroid and pancreas, cataracts, nephropathy and myocardial changes in rats.