Epidemiologiske forsøg har påvist, at patienter, som behandles med venlafaxin, har en større byrde af selvmordsrisikofaktorer end SSRI- patienter.
The extent to which the finding of an increased risk of fatal outcomes can be attributed to the toxicity of venlafaxine in overdosage, as opposed to some characteristics of venlafaxine-treated patients, is not clear.