Der er set et øget antal alvorlige kardiovaskulære hændelser, hovedsagelig myokardieinfarkt, i placebokontrollerede langtidsstudier hos personer med sporadisk adenomatøs polypose
Increased number of serious cardiovascular events, mainly myocardial infarction, has been found in a long-term placebo-controlled study in subjects with sporadic adenomatous polyps treated with celecoxib at doses of 200mg BID and 400mg BID compared to placebo (see 5.1).