Der er set øvre gastrointestinale komplikationer (perforationer, ulcera og blødninger (PUB)), nogle med fatal udgang hos patienter behandlet med celecoxib.
4.4 Special warnings and special precautions for use Upper gastrointestinal complications [perforations, ulcers or bleedings (PUBs)], some of them resulting in fatal outcome, have occurred in patients treated with celecoxib.