0, 8 gange den systemiske eksponering hos ældre forsøgspersoner ved den maksimalt anbefalede terapeutiske dosis på 80 mg dagligt.
However, in the repeated dose toxicity studies in dogs and rats, the systemic exposures to valdecoxib (the active metabolite of parecoxib) were approximately 0.8-fold the systemic exposure in elderly human subjects at the maximum recommended therapeutic dose of 80 mg daily.