Ud over hydrolyse elimineres topotecan overvejende renalt som en mindre komponent, der metaboliseres til N- desmetylmetabolit (SB- 209780) og er fundet i plasma, urin og fæces.
Other than hydrolysis, topotecan is cleared predominantly renally, with a minor component metabolized to the N-desmethyl metabolite (SB-209780) identified in plasma, urine and faeces.