De mest almindelige bivirkninger med, som minimum, en mulig relation til telbivudin var grad 3/ 4 forhøjelser af kreatininkinase i blodet (6, 8%), træthed (4, 4%), hovedpine (3, 0%) og kvalme (2, 6%).
The most common adverse events with at least a possible relation to telbivudine were grade 3/ 4 blood creatine kinase elevations (6.8%), fatigue (4.4%), headache (3.0%) and nausea (2.6%).