In vitro undersøgelser har også vist, at bivalirudin forlænger den aktiverede partielle tromboplastintid (aPTT), trombintiden (TT) og pro- trombintiden (PT) i normal human plasma på en koncentrationsafhængig måde og at bivalirudin ikke inducerer blodpladeaggregationsrespons mod sera fra patienter med kendt tidligere Heparin- Induceret- Trombocytopeni/ Trombose Syndrom (HIT/ HITTS).
In vitro studies have also shown that bivalirudin prolongs the activated partial thromboplastin time (aPTT) thrombin time (TT) and pro-thrombin time (PT) of normal human plasma in a concentration- dependent manner and that bivalirudin does not induce a platelet aggregation response against sera from patients with a history of Heparin-Induced Thrombocytopenia/ Thrombosis Syndrome (HIT/ HITTS).