De to første undersøgelser omfattede 991 patienter, hos hvem methotrexat ikke havde virket tilfredsstillende, mens den tredje omfattede 391 patienter, hos hvem TNF- hæmmere ikke havde virket tilfredsstillende.
The first two studies included 991 patients who had not had an adequate response to methotrexate, and the third included 391 patients who had not had an adequate response to TNF blockers in the past.