Elimination via leveren spiller en relativt stor rolle (~70%) i den fuldstændige clearance for Suboxone, og virkningsvarigheden for buprenorphin kan være forlænget hos personer med nedsat leverclearance.
Hepatic elimination plays a relatively large role (~70%) in the overall clearance of Suboxone and the action of buprenorphine may be prolonged in subjects with impaired hepatic clearance.