Virkningen af aprepitant på plasmakoncentrationen af intravenøst administrerede CYP3A4- substrater forventes at være mindre.
The AUC of orally administered CYP3A4 substrates may increase up to approximately 3-fold during the 3-day treatment with fosaprepitant followed by oral aprepitant; the effect of aprepitant on the plasma concentrations of intravenously administered CYP3A4 substrates is expected to be smaller.