Toksicitet hos dyr udsat for gentagen eller kontinuerlig eksponering (fra 1 dag til 4 ugers behandlingsniveau med op til 10 gange klinisk steady state plasmakoncentration) var begrænset til overdreven farmakologisk effekt.
Toxicity in animals upon repeated or continuous exposure (1 day to 4 weeks at exposure levels of up to 10 times the clinical steady state plasma concentration) was limited to exaggerated pharmacological effects.