Det er blevet påvist, at der er en højaffinitetsreceptor i renal cortex som det primære bindingssted for den thiaziddiuretiske virkning og hæmning af NaC1- transport i tubulus contortus distalis.
It has been shown that there is a high-affinity receptor in the renal cortex as the primary binding site for the thiazide diuretic action and inhibition of NaCl transport in the distal convoluted tubule.