Der blev observeret histopatologiske ændringerne i ledbrusken i de vægtbærende led hos unge (3, 5 måneder gamle) beagle hunde efter oral administration af difloxacin (som hydrochlorid) ved doser over 5 mg/ kg/ dag i 90 dage.
Histopathological changes were noted in the articular cartilage of weight bearing joints of young (3.5 months old) beagle dogs after the oral administration of difloxacin at doses of greater than 5 mg/ kg/ day for 90 days.