Forsøg med mennesker og in vitro- forsøg, hvor der anvendes humane levermikrosomer og udtrykte enzymer viste, at maraviroc fortrinsvis metaboliseres af cytochrom P450- systemet til metabolitter, der er essentielt inaktive over for HIV- 1.
14 Metabolism: studies in humans and in vitro studies using human liver microsomes and expressed enzymes have demonstrated that maraviroc is principally metabolized by the cytochrome P450 system to metabolites that are essentially inactive against HIV-1.