Ved gentagen dosering opnås den antihypertensive effekt i væsentlig grad inden for 2 uger, og maksimale effekter opnås inden for 4 uger og opretholdes under vedvarende behandling.
During repeated dosing, the antihypertensive effect is substantially present within 2 weeks, and maximal effects are attained within 4 weeks and persist during long-term therapy.