På trods af dette er Irbesartan Krka uden risiko blevet administreret sammen med andre antihypertensive lægemidler som beta- blokkere, langtidsvirkende calcium- antagonister samt diuretika af thiazidtypen.
Other antihypertensive agents may increase the hypotensive effects of irbesartan; however Irbesartan Krka has been safely administered with other antihypertensive agents, such as beta-blockers, long- acting calcium channel blockers, and thiazide diuretics.