Endvidere kan det at skifte fra leflunomid til et andet DMARD uden at følge "wash- out" proceduren (se afsnit 4. 4) også øge risikoen for alvorlige bivirkninger selv lang tid efter præparatskiftet.
Moreover, switching from leflunomide to another DMARD without following the washout procedure (see section 4.4) may also increase the risk of serious adverse reactions even for a long time after the switching.