Streptozotocin treatment alters the IR/PI3K/AKT pathway in Ntg and tauKO mice. A: Immunoblot analyses of pIR, IR, pPI3k(p85), PI3k, pAKT(Ser473), AKT, GSK3β (Ser9), and GSK3β of protein extracts from whole-brain homogenates of Ntg, Ntg-STZ, tauKO, and tauKO-STZ mice at 5 months of age are shown on alternating lanes. B: Quantification normalized to GAPDH and expressed as percentage of control. Pairwise comparisons: ∗ P