YAC128 HD mice have an altered peripheral response to neonatal iron supplementation. Mice were supplemented at 10–17 days and sacrificed at 1-year of age. A. Neonatal iron supplementation results in decreased serum iron at 1-year of age in wild-type but not YAC128 HD mice. n = 8–10, B. Iron-supplemented YAC128 HD, but not wild-type mice have significantly decreased liver iron at 1-year of age. P-value: *p < 0.05, n = 12–13.