Dectin-1 differentially impacts the AhR/IL-22 axis in the different mouse strains. ( a , c ) Ahr expression and IL-22 production in vivo or ( b , d ) in vitro in wild-type and Dectin-1 –/– mice from the ( a , b ) C57BL/6 or ( c , d ) BALB/c mice infected i.g. with C. albicans Vir 3 at 4 dpi. Ahr and Il22 expression (real-time RT-PCR) and IL-22 production (ELISA) were performed on ex vivo Peyer's patches cells from naive (−) or infected (+) mice or in cells from naive mice stimulated in vitro with β-glucan or FICZ for 18 h. * P ≤0.05, ** P ≤0.01 and *** P ≤0.001, wild-type vs. Dectin-1 –/– mice in either background, as indicated. C. albicans ; Candida albicans ; dpi, days post-infection; FICZ, 6-formylindolo[3,2-b]carbazole; i.g., intragastrically; RT-PCR, reverse transcriptase PCR.