IL-6 secreted by CC-MSCs enhances the proliferation, migration and invasion of colorectal cancer cells through IL-6/JAK2/STAT3 signaling. a The levels of various factors in the cell-free culture supernatants were measured using Bio-Plex cytokine arrays. b Quantitative analysis of IL-6 levels using enzyme-linked immunosorbent assay (ELISA). The conditioned media from the cultured CC-MSCs and SW48 cells were collected to detect the levels of IL-6, and representative results from one of the three independent experiments are presented. c Transwell migration (top) and invasion (bottom) assay of SW48 cells with or without 10 ng/mL recombinant IL-6 treatment (×100). d Colony-formation assay of SW48 cells treated with or without 10 ng/mL recombinant IL-6. e Wound-healing assay of SW48 cells in the presence or absence of recombinant IL-6 (magnification, ×50; scale bar: 500 μm). *** P