"A 77-year-old woman with a history of bilateral exudative macular degeneration received intravitreal adipose-derived ""stem cell"" injections in both eyes. Her baseline optical coherence tomography (OCT) images are shown 4 months prior to the injections in the right (A) and left (B) eyes. Three weeks after ""stem cell"" injections, the normal retinal contour was blunted by epiretinal membrane (ERM) formation in the right (C) and left (D) eyes. Vitreous hemorrhage and debris were noted bilaterally. Five weeks after ""stem cell"" injections, the ERM in the right eye progressed, resulting in progressive irregularities in the retinal contour (E). The left eye developed a tractional retinal detachment (F). By 7 months after the ""stem cell"" injections, the patient had undergone a retinal detachment repair in the right eye at an outside institution. Fundus photographs show recurrent rhegmatogenous/tractional retinal detachments with proliferative vitreoretinopathy in the right (G) and left (H) eyes. The view in the left eye is limited by a brunescent cataract. OCT imaging showed detachment of the right macula with a thin, hyperreflective overlying membrane (I). OCT imaging of the left eye showed thinned and atrophic retina with a thin, hyperreflective overlying membrane (J). The initial vision was 20/200 in the right eye and 20/400 in the left eye. Visual acuity 7 months after the ""stem cell"" injections was hand motions in the right eye and light perception in the left eye."