Insulin regimens. Profiles of soluble insulins are shown as blue lines and intermediate- or long-acting insulin as purple lines. The arrows indicate when the injections are given. (a) Twice daily soluble and intermediate. (b) Splitting the evening injection. (c) Three times daily soluble with additional intermediate or long-acting insulin given before bedtime. B, breakfast; L, lunch; S, supper; Sn, snack (bedtime).