Image: Neuropathologic analysis of brain tissue from FTLD patients. Ubiquitin immunohistochemistry in cases of familial FTLD demonstrates staining of (a) neurites and neuronal cytoplasmic inclusions in the superficial cerebral neocortex, (b) neuronal cytoplasmic inclusions in hippocampal dentate granule cells, and (c) neuronal intranuclear inclusions in the cerebral neocortex (arrows). (Photo courtesy of Wikimedia Commons)