Melanoma and germline mutations CDKN2A the most common gene altered in melanoma families Can affect the p16 and the p14 protein Can affect the p16 and the p14 protein CDK4 mutations are rare CDK4 mutations are rare CDKN2A accounts for up to 25% of melanoma families CDKN2A accounts for up to 25% of melanoma families p16 involved in cell cycle and senescence p16 involved in cell cycle and senescence