The i.c.v. injection of M617 significantly elevated GLUT4 mRNA expression levels in adipose cells (n = 8). The GLUT4 mRNA expression levels were higher in diabetic M617 (D-M617) and nondiabetic M617 (N-M617) groups as compared with diabetic controls (DC) and nondiabetic controls (NC), respectively. The expression levels were lower in D-M617 and DC groups compared with N-M617 and NC groups, respectively. The data shown are the means ± SEM. △P < 0.05, △△P < 0.01 versus NC; ●●P < 0.01 versus N-M617; ○○P < 0.01 versus DC.