Changes on histological profiles and proinflammatory genes in the paw. (a) In each rat, cutaneous regions of dorsum and ventrum pedis were stained with H&E and used for histological sample preparation in this study. Arrow indicated total thicknesses measured, and arrow heads were infiltrated inflammatory cells. Scale bars = 160 μm. Inset of upper picture is the macrophotography to show more precisely the infiltration of inflammatory cells. (b) The levels of mRNAs in the paw of rats analyzed by real-time PCR. Values represent the mean ± S.E.M. (significantly different as compared to carrageenan-treated group, *P < 0.05, *P < 0.01). BSE: Bojesodok-eum.