<p>Fig. 1: Strategies for Lowering Mutant Huntingtin Levels. Different approaches for lowering mutant huntingtin (mHTT) include using clustered regularly interspaced short palindromic repeats (CRISPR)‑Cas9 to edit DNA so mHTT is not transcribed, antisense oligonucleotides (ASOs) to reduce production of mRNA during processing (splicing) of pre-mRNA, microscopic or small interfering RNA (miRNA or siRNA) to reduce production of mHTT protein during mRNA translation, and protein modulation to reduce aggregation or increase clearance.</p>