(A) Photomicrographs in a higher original objective (x40) of the different groups (SHAM, OVX, and RLX) and periods (14 and 42 days), in which is possible to observe an increased area of diaminobenzidine-stained cells (brown areas) around the peri-implant bone where the biomarker WNT were intense, represented by black arrows, denoting an improvement in the bone formation; (B) The chart shows the scores submitted to the Kappa test, in which the index was adjusted to > 0.8, representing the expression of WNT among the groups and in both periods; (C and D) Photomicrographs in a higher original objective (x100) about the 14 and 42 days of peri-implant bone healing from RLX group showing an intense labeling of WNT pathway represented by red arrows