CIIA inhibits SOD1(G93A)-induced reduction of mitochondria membrane potential (Δψ m ) and the release of cytochrome c . NSC34 cells were stably transfected with plasmid vectors encoding Flag-tagged SOD1(WT) or SOD1(G93A) along with vectors for GFP or CIIA siRNA. (A) mitochondria membrane potential (Δψ m ) was analyzed by measuring the fluorescence intensity of tetramethyl rhodamine methyl ester (TMRM, a mitochondria potential sensor). Quantitative data are mean ± s.e.m. from three independent experiments. * P