Resv promotes early dephosphorylation of ATM, inhibition of BCL-2, and upregulation of BAX. MCF-7 R cells were treated with CDDP (6 μM) with or without Resv (100 μM) for 6 h. ( A ) Total and phospho-ATM and ( B ) BCL-2 and BAX proteins were assessed by Western blot using antibodies directed against total ATM, a specific phosphorylated residue on S1981 of ATM, BCL-2, or BAX. MCF-7 cells with CDPP were used as positive control of ATM phosphorylation. ( C ) Densitometric analysis of BCL-2 and ( D ) BAX after β-actin normalization. ( E ) Ratio between BCL-2/BAX by t test. All results are presented as mean of three independent experiments ± SD. * p