SB suppresses TPA-induced inflammation. ( A ) Effect of SB on chronic TPA-induced hyperplasia (top) proliferation (middle) and apoptosis (bottom) ( B ) Decreased cutaneous neutrophils (MPO+ cells) after acute and chronic TPA + SB treatment. ( C ) Decreased keratinocyte chemokine (KC) and macrophage-inflammatory protein 2 (MIP2) gene expression in acute and chronically SB- and TPA-treated whole skin. Results normalized to TPA only samples. Reverse transcription–polymerase chain reaction showing induction of these chemokines by TPA (bottom). n = 4–6 mice per treatment group. A, acetone.