Protein levels of IL-1β (a) and PSD95 (b) in hippocampal homogenate. Obtained at sacrifice at end of treatment in vehicle-treated young rats and aged rats treated with vehicle or 0.5, 1.5, or 4.5 mg/kg of VX-745. 4.5 mg/kg VX-745 demonstrated significantly reduced IL-1β levels (p = 0.038 by Mann-Whitney rank sum test) and a trend toward increased PSD95 levels (p = 0.06) compared to vehicle-treated aged rats.