Discussion Sirolimus Sirolimus Immunosuppressive/ anti-rejection drug Immunosuppressive/ anti-rejection drug Non-nephrotoxic Non-nephrotoxic Fibrinoid necrosis in GI previously reported in rhesus macaques receiving sirolimus, tacrolimus, and daclizumab to prevent renal allograft rejection – attributed to sirolimus toxicity Fibrinoid necrosis in GI previously reported in rhesus macaques receiving sirolimus, tacrolimus, and daclizumab to prevent renal allograft rejection – attributed to sirolimus toxicity Link between sirolimus and fibrinoid necrosis shown in some species, absent in others Link between sirolimus and fibrinoid necrosis shown in some species, absent in others Not seen in other transplant studies at Yerkes Not seen in other transplant studies at Yerkes Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only