p38 mapks (P38 mitogen-activated protein kinases) which include p38 isoforms α, β, γ, and δ are a member of mitogen-activated protein kinases family. p38 mapk can be activated by LPS, proinflammatory cytokines, various environmental stresses. p38 MAPK phosphorylates various substrates including MAPK-activated protein kinase 2 (MAPKAPK2). p38 MAPK which is activated in the human brain with Alzheimer's disease plays more than one role in Alzheimer's disease (AD).