Images of the right eye of the proband (III:3) before and after treatment with oral 250 mg acetazolamide tablets twice daily and 2% dorzolamide collyrium. Spectral-domain optical coherence tomography (OCT) images from the vertical and horizontal scans centered on the fovea showing schisis in the ganglion cell layer in the parafoveal region and in the inner nuclear layer from the foveal to the extrafoveal region (A, top panel). En face OCT showing schitic cysts in a radial pattern in the foveal and parafoveal areas before treatment (B, top panel). Corresponding OCT angiography (OCTA) perfusion maps showing vessel density reduction in the foveal and parafoveal areas in the superficial and deep capillary plexuses (C and D, top panel, respectively). After treatment, there is a reduction of central retinal thickness (A, bottom panel) on spectral-domain OCT and partial resolution of schitic cysts particularly in the temporal area (B, bottom panel) on en face OCT. Vessel density partially increases after treatment on OCTA (C and D, top and bottom panels).