"Don't Mix Citrus with Some MedsGrapefruit, limes, Seville oranges, pomelos (which are similar to grapefruits) and tangelos (a tangerine-grapefruit hybrid) contain a compound that impairs your body's ability to break down some 43 drugs (up from 17 in 2008, according to a study in the Canadian Medical Association Journal). So citrus plus statin cholesterol medications, the blood pressure medication nifedipine and the painkiller oxycodone may up your dose to three times what the doc prescribed. James Winger, MD, assistant professor in the department of family medicine at Loyola University Chicago, suggests asking your doctor or pharmacist if your medications carry this risk. And if so, ""skip the fruit and juice—no amount is safe,"" he says. Photo: Ross Durant Photography, Getty Images / (c) Ross Durant Photography"