URICOSURIC AGENTS Probenecid, (Losartan & fenofibrate for mild disease) Probenecid, (Losartan & fenofibrate for mild disease) Increased secretion of urate into urine Increased secretion of urate into urine Reverses most common physiologic abnormality in gout ( 90% pt.s are underexcretors) Reverses most common physiologic abnormality in gout ( 90% pt.s are underexcretors)