Effects of chelerythrine or calphostin C, an inhibitor of protein kinase C, on PWS-induced pacemaker potentials in cultured ICCs of the murine small intestine. A, B: ICCs were isolated from the Balb/c small intestine after primary cell culture for various doses of PSW (5 to 50 mg/mL) and the clamping mode (I = 0). Pacemaker potentials of ICCs exposed to PWS (30 mg/ml) in the presence of chelerythrine (1 ㎛) or calphostin C (10 ㎛) are shown. Under these conditions, PWS did not cause membrane depolarizations. C: Summary of the responses to PWS in the presence of chelerythrine or calphostin C. Bars represent the mean values ± SE **(P < 0.01) Significantly different from the untreated control. CTRL: Control.