Innate immune response induced using β-glucan, but not Pam3Cys or LPS, produced significant delay in hyperglycemia A) 10-week-old pre-diabetic female NOD mice were injected with β-glucan (5 μg/mouse/day), zymosan (5 μg/mouse/day), Pam3Cys (1.0 μg/mouse/day) and bacterial LPS (0.5 μg/mouse/day); for three alternate days or left untreated (control). Mice were checked every week for hyperglycemia for up to 15 weeks and mice with glucose level of 250 mg/dl for two consecutive weeks were considered diabetic. Log-rank test was performed to compare the hyperglycemia incidence in treated and control groups of mice and the statistically significant p -value is shown.