Hcrt-specific autoreactive T cells detected using the T cell library method. Each dot represents a single T cell, with proliferation measured in response to peptide stimulation reported in counts per minute (c.p.m) after incubation with [3H]-thymidine to label proliferating cells. 'Positive' T cell responses were considered > 2,000 c.p.m as the background (unstimulated) proliferation rate was ~1,500 c.p.m. Note the strong proliferative response of T cells to hcrt peptide fragments in narcoleptics (P#) versus controls (C#). (NT1 = narcolepsy type 1, NT2 = narcolepsy type 2) (Latorre et al., 2018).