Effects of treatments on renal chemokines expression. (A) Representative immunoblots of protein expression of MCP-1 and ICAM-1 in renal tissues of STZ-diabetic rats treated for eight weeks with zerumbone (ZER) or rosiglitazone (RGZ). STZ-diabetic rats were dosed by oral gavage once daily for eight weeks with 20 mg/kg ZER (ZER 20), 40 mg/kg ZER (ZER 40) or 5 mg/kg RGZ (RGZ). Normal (normal + VEH) or STZ-diabetic rats receiving vehicle treatment (STZ + VEH) were administered the same volume of vehicle (VEH) used to dissolve test medications. (B) Ratio of MCP-1/β-actin or ICAM-1/β-actin is expressed as the mean with SD (n = 4 per group) in each column. ap < 0.01 and bp < 0.01 compared to vehicle-treated normal rats. cp < 0.05 and dp < 0.01 compared to vehicle-treated STZ-diabetic rats, respectively.