lack of interaction between a polymorphism in the dopamine d2 receptor gene and the clinical features of migraine the purpose of this study was to evaluate whether a particular genotype of the dopamine d2 receptor drd2 gene would affect the clinical features of migraine in a group of 118 migraineurs 55 migraine with aura and 63 migraine without aura patients we tested the association of the biallelic ct ncoi drd2 polymorphism with several characteristics of the disease genotype and allele frequencies resulted similarly distributed in migraine with aura and migraine without aura patients chi2 158 p 045 and chi2 009 p 077 respectively the different drd2 genotypes cc ct and tt had no significant effects on age at onset of migraine presence of premonitory phenomena frequency of headache attacks associated symptoms psychological features and quality of life of our migraine patients the results of our study do not support a role for the drd2 gene in modifying the clinical features of migraine