associations between enos polymorphisms and susceptibility to behcets disease a metaanalysis objective to determine whether endothelial nitric oxide synthase enos polymorphisms confer susceptibility to behcets disease bdmethods a metaanalysis was conducted on the associations between the g894t and 4ba polymorphisms of enos and bd using i the allele contrast ii the recessive model iii the dominant model and iv the additive modelresults a total of eight studies which included 841 cases and 866 controls were included in the metaanalysis metaanalysis of the g894t polymorphism revealed no association with bd in all study subjects or in turkish and asian populations however one tunisian study of the t allele showed a significant association with bd or 0707 95 ci 05100980 p 0038 but the or of the t allele among tunisians was lower whereas it was higher in europeans or 2129 95 ci 14073220 p 00003 metaanalysis showed no association between bd and the 4ba polymorphism in all study subjects stratification by ethnicity indicated no significant association between the a allele of the 4ba polymorphism and bd in turkish and asian populationsconclusions this metaanalysis shows that the enos g894t and the 4ba polymorphisms are not associated with bd in the turkish and asian populations these data suggest that the g894t and the 4ba polymorphisms may not confer susceptibility to bd in the turkish and asian populations