treatment of cutaneous t cell lymphoma with intermediate doses of interferon alpha 2a in this study we treated 6 patients with epidermotropic cutaneous t cell lymphoma ctcl with intermediate doses of recombinant alpha 2a interferon 18100 x 106 iuweek for 26 months one patient experienced complete clinical remission in spite of a persistent dense lymphocytic skin infiltrate one patient was markedly improved and 2 patients were moderately improved the clinical condition of the 2 remaining patients was unchanged by interferon treatment in all cases lesions relapsed a few weeks after treatment was discontinued this study shows that interferon can be used to treat epidermotropic ctcl however a 2 to 6month treatment using moderate doses did not lead to the high percentage of remission previously reported by others with high doses of recombinant alpha 2a interferon for longer periods this result suggests that interferon should be used at high doses andor for long time periods for clinical improvement of ctcl patients