interaction of drugcarrier systems with targetsa study using atomic force microscopy to learn about the interaction between drug agents and nanoparticular carrier systems the physical analytical methods of parelectric electron spin and fluorescence spectroscopy have proven helpful tools to yield descriptive models of such complex systems for a deeper understanding of drug absorption from body surfaces and drug distribution into the tissues however the lack of knowledge about the interaction between such agents and membranes on different levels is a severe drawback this gap can be closed by the application of atomic force microscopy at normal temperatures and under the admission of liquid surroundings moreover this method allows the inspection of such systemmembrane interactions in dependence on time we studied membrane topography in liquid and gelphase mixtures structural changes of membranes during their destruction by aqueous peptide solutions as well as the stability of the membranes exposed to surfactants of increasing concentration and to lipid nanoparticles solid lipid nanoparticles nanostructured lipid carriers for future modelling we can describe the geometry of lipid nanoparticles as well