acute toxicity studies of croton membranaceus root extract aim of the study croton membranaceus root and leaf extracts are used in the bahamas to aromatize tobacco in nigeria to improve digestion and in ghana for benign prostate hyperplasia despite claims of success there is paucity of information on its toxicity the aim of this study was to determine if croton membranaceus has acute toxicity propertiesmaterials and methods roots were airdried in a solar dryer for one week before milling the powder was extracted with 96 ethanol freezedried and reextracted with distilled water and freezedried 15 male spraguedawley rats 180200 g were divided equally into 2 treatment groups low dose ld and high dose hd plus a control group c ld and hd received 1500 and 3000 mgkg bwt croton membranaceus aqueous extract respectively one time and observed for 14 days haematological full blood count and haemoglobin hb biochemical bilirubin alanine aminotransferase ala aspartate aminotransferase ast total protein albumin globulin alkaline phosphatise alp glutamyltranspetidase ggt urea creatinine creatinine kinase muscle and brain ckmb creatinine kinase total ckr examinations were performedresults control groups ckmb 5444534 ul and ld group ckmb 40141016 ul were significantly different p005 control and the hd group ckmb 39551135 ul were significantly different p005 both ld and hd ckr levels 697197ul and 732203 ul respectively were lower than the control 1139220 ul at 48 h and 14 days p005 p005 respectively gt levels of the hd group was 4804 ul compared to the control group value of 0902 ul p005conclusions taking all factors into consideration croton membranaceus ingestion does not produce general acute toxicity however its creatinine kinase lowering ability could be explored