the effect of ligustrazine on cells proliferation in cortex and striatum after focal cerebral ischemia in adult rats objective to explore the effect of ligustrazine on cells proliferation in cortex and striatum after focal cerebral ischemia in adult ratsmethods focal cerebral ischemia was induced by left middle cerebral artery occlusion mcao with suture method two hours later injection of ligustrazine 80 mgkg 1 timed was performed peritoneally four hours after the ischemia 5bromodeoxyuridine brdu 50 mgkg 1 timed was injected peritoneally at 7d 14d and 21d after ischemia brdulabeled cells in the cortex and striatum were observed by immunohistochemical stainingresults in ischemia model group at 7 day brdulabeled cells were observed in the ipsilateral cortex and striatum with the prolongation of ischemia the number of brdulabeled cells increased reached the peak at 21d in ligustrazine group brdulabeded cells were observed with an intense distribution in ischemic penumbra of the cortex and striatum with the prolongation of ischemia the number of brdulabeled cells increased significantly at 14d and reached the peak at 21d the numbers of brdulabeled cells at 7d 14d and 21d were more than those in ischemia model group respectivelyconclusion ligustrazine increase the proliferated cells in the cortex and striatum after focal cerebral ischemia in adult rats the results suggest that it may be useful for promoting selfrepair after ischemia