human cd4 cd25 high cells suppress proliferative memory lymphocyte responses to herpes simplex virus type 2 lymphocytes with the regulatory cd4 cd25 phenotype frequently suppress memory tcell responses murine herpes simplex virus type 1 hsv1 models have shown that cd4 cd25 cells can limit immunitymediated corneal damage but slow viral clearance we investigated the effect of cd4 cd25 cells from healthy hsv2infected humans on recall proliferative cd4 responses to hsv2 depletion and reconstitution experiments were consistent with a suppressive effect of autologous bloodderived cd4 cd25 cells for whole hsv2 antigen regulatory t cells may modulate human cd4 memory responses to hsv2 and influence their antiviral and inflammatory functions