a cosmic event in 2015 fused earth with the faerie realm scientists referred to the event as the anomaly a byproduct of the anomaly was the advent of hybrid beingspeople who became mixed with whatever animal or object was closest to them the moment the event occurred humans or pedigrees soon relegated fairy refugees and hybrids into ghetto zones in large citiesseventy years later wolfgang rex a secondgeneration hybridpart human part rhodesian ridgebackis a retired police detective who runs a private investigation business in chicagos southside its a onehybrid show though rex couldnt survive without his assistant the faerie sally sandwebone night two vampires visit rex and offer him a substantial reward for the recovery of a stolen scroll later that same evening charlotte sweeneyjarhadill a pedigree woman from louisiana visits rex and hires him to exorcize the headless ghost of a confederate soldier from her hometo complicate matters the private detective ends up falling for charlotte meanwhile the vampires demand results in the search for the missing scroll when rexs assistant sally goes missing he must stay alive long enough to find her charlotte and the vampires however have other plans for rex