reactive selfassembly and specific cellular delivery of ncospeostatpoderived nanogels this study presents the reactive selfassembly of isocyanate functional and amphiphilic sixarm starshaped polyether prepolymers in water into nanogels intrinsic molecular amphiphilicity mainly driven by the isophorone moiety at the distal endings of the starshaped molecules allows for the preparation of spherical particles with an adjustable size of 100200 nm by selfassembly and subsequent covalent crosslinking without the need for organic solvents or surfactants covalent attachment of a fluorescence dye and either the cellpenetrating tat peptide or a random control peptide sequence shows that only tatlabeled nanogels are internalized by hela cells the nanogels thus specifically enter the cells and accumulate in the perinuclear area in a time and concentrationdependent manner