evaluation on the efficacy of recombinant hepatitis b vaccine booster immunization in 2789 children aged over 10 years objective to study the efficiency of booster immunization with different recombinant hepatitis b vaccinesmethods 2789 children aged over 10 years who had completed the basic immunization of hepatitis b vaccine under 1 year old were selected all the sampled children were classified into four groups a b c and d and immunized with different hepatitis b vaccines produced by different companies respectively before booster immunization their blood plasma specimens were detected for hepatitis b virus hbv surface antigen hbsag antibodies to hbv surface antigen antihbs and antibodies to hbv core antigen antihbc by chemiluminescence in each group the antihbs positive children were immunized with one dosage and antihbs negative children were immunized three dosages of the same vaccine their blood specimens were collected again after 1 month and detected for antihbsresults the antihbs positive rates of a b c and d group were 3643 3759 4291 and 4646 respectively before immunization while 8920 9152 9096 and 8545 respectively after immunization with one dosage 9912 9947 9887 and 9885 respectively after immunization with three dosages the differences of antihbs positive rates in the four respective groups showed statistical significances between any two rates of preimmunization postimmunization with one dosage and postimmunization with three dosages all p 005 the antihbs positive conversion rates of four groups were 8301 8641 8416 and 7282 respectively after immunization with one dosage the antihbs positive conversion rate of four groups were 9862 9916 9803 and 9784 respectively after immunization with three dosages and the difference of positive conversion rates in each group showed statistical significances between booster immunization with one dosage and booster immunization with three dosages the average gmts in antihbs positive children in the four groups were 285321 625423 358140 and 302132 miuml respectively after immunization with one dosage the average gmts of antihbs negative children in the four groups were 27308 64852 38787 and 24536 miuml respectively after immunization with one dosage and were 63230 234114 56397 and 39408 miuml respectively after immunization with three dosagesconclusion our data showed that it would be suitable to anyone to use the four vaccines for antihbs positive children aged over 10 years with one dosage and for antihbs negative children aged over 10 years with three dosage booster immunization