inhibition of experimental corneal neovascularisation by bevacizumab avastin aim to evaluate the effect of topically administered bevacizumab avastin on experimental corneal neovascularisation in ratsmethods silver nitrate sticks 75 silver nitrate 25 potassium nitrate were used to perform chemical cauterisation on the corneas of 16 eyes from 16 male long evans rats for the following 7 days the 10 eyes in the treatment group were instilled with bevacizumab 4 mgml drops twice daily whereas the 6 eyes in the control group received placebo normal saline drops twice daily digital photographs of the cornea were analysed to determine the area of cornea covered by neovascularisation as a percentage of the total corneal arearesults in the bevacizumabtreated eyes neovascularisation covered on average 382 155 mean sd of the corneal surface compared with 635 50 in the control group p002 mannwhitney u testconclusion topically administered bevacizumab avastin at a concentration of 4 mgml limits corneal neovascularisation following chemical injury in the male long evans rat model