colony density influences invasive and filamentous growth in saccharomyces cerevisiae the effect of colony density on the dimorphic switch was determined in natural strains of saccharomyces cerevisiae in some strains invasiveness and pseudohyphal ph growth were highly sensitive to colony density moreover strains constitutively able to invade the substrate with ph formation positively influenced the invasiveness but not the ph growth of a different strain less prone to the dimorphic switch fatality from disseminated intravascular coagulation complicating total hip arthroplasty a case report following a routine hybrid total hip arthroplasty in an eightytwo yearold female profuse bleeding occurred through the suction drain immediately postoperatively the patient was found to have acute disseminated intravascular coagulation despite early recognition and treatment the patient died fourteen days later