new possibilities of treating acute angioedema caused by c1inhibitor deficiency the authors discuss diagnostic difficulties in 12 cases of hereditary angioneurotic edema due to c1esterase inhibitor c1inh deficiency emphasis is on the treatment of the acute attacks with intravenous infusions of c1inhibitor concentrate boehring west germany this proved to be a very efficient and safe therapy leading to a prompt disappearance of all clinical symptoms throughout 12 months following the infusions indices of the liver function remained within the normal range and antihbs and antihiv tests were negative smallmolecule fluorescent probes for specific rna targets a method was developed that uses small molecules as fluorescent probes to detect specific mrnas in this approach the fluorescence of fluorophorequencher conjugates is restored by the binding of an mrna aptamer tag to the quencher segment of the molecules the method allows realtime detection of mrna transcripts in vitro