apolipoprotein a1 rs5070 ag polymorphism with stroke subtypes in taiwan background apolipoprotein a1 apoa1 is a structural protein of highdensity lipoprotein cholesterol apoa1 is involved in lipid and cholesterol metabolism this study evaluated the association of apoa1 polymorphism rs5070 with different stroke subtypes in taiwanese individualsmethods a total of 2139 cases including 614 controls and 708 large artery atherosclerosis laa 377 smallvessel occlusion and 440 hypertensive intracranial hemorrhage cases were enrolled in this study apoa1 polymorphism was genotyped through polymerase chain reaction amplification and then subjected to massassisted laser desorption ionization timeofflight mass spectrometry using a bruker snp genotyping system in the national center for genome medicine academia sinica taipei taiwan the frequency of apoa1 rs5070 dominant genotype aa vs aggg was not significantly different among laa smallvessel occlusion and hypertensive intracranial hemorrhage groups compared with that of the control group compared with diabetic patients with the aa allele those with the aggg allele of apoa1 rs5070 polymorphism showed a 158fold likelihood of developing laa odds ratio158 95 confidence interval100242 p0046 but not smallvessel occlusion or hypertensive intracranial hemorrhage in male diabetic patients the odds ratio increased to 190foldconclusion our findings suggested that genetic polymorphisms of apoa1 rs5070 ag may play a role in the susceptibility to laa among male diabetic patients