barofunction of auditory tube in patients with central perforation of tympanic membrane patients with otitis media chronica with central tympanic perforation underwent glue myringoplasty or radical operation in 522 and 333 of them an original technique developed by the authors has discovered defect of barofunction of the auditory tube named inflation effect of the auditory tube high intratympanic pressure observed in this effect should be taken into consideration in tympanoplasty as it underlies rupture or dislocation of the transplant in myringoplasty or dislocation of the neotympanic membrane in reconstructive surgery on the middle ear isolated vasculitis of the central nervous system in a patient with celiac disease a 51yearold white man with celiac disease presented with seizures unresponsive to medical therapy investigations including brain biopsy revealed isolated vasculitis of the central nervous system treatment with prednisone and cyclophosphamide resulted in clinical and radiographic improvement the relationship between celiac disease and vasculitis is discussed