design synthesis and biological activities of novel azolebonded hydroxypropyl oxime oethers the synthesis and biological effects of 15 novel azolebonded hydroxypropyl oxime oethers have been described in this synthesis the oximation of aromatic ketones followed by an oalkylation reaction with epichlorohydrin andor epibromohydrin led to the corresponding ooxime ether adducts subsequently the attained ooxime ether adducts were used to synthesize the target molecules after treating them with the appropriate azole derivatives the in vitro antifungal and antibacterial activities of title compounds were obtained against several pathogenic fungi grampositive andor gramnegative bacteria benzophenone o2hydroxy32phenyl1 himidazol1yl propyl oxime and 9hfluoren9one o2hydroxy32phenyl1 himidazol1ylpropyl oxime proved to have considerable antifungal activity against candida albicans candida krusei aspergillus niger and trichophyton rubrum these two compounds demonstrated comparable antifungal activity to clotrimazole and fluconazole standard drugs all compounds were also tested against escherichia coli and staphylococcus aureus as gramnegative and grampositive bacteria respectively and their activities were compared to gentamycin and ampicillin reference drugs in general marginal antibacterial activity against tested bacteria was observed for the title compounds a molecular docking study is also discussed for the two most potent compounds against fungi the docking study reveals a considerable interaction between the two most potent compounds and the active site of mycobacterium p450dm moreover these two compounds are much strongly bound to the active site of mycobacterium p450dm compared to fluconazole