lipoproteina is not elevated in nondiabetic microalbuminuric subjects a longitudinal study of lipoproteina concentrations and apolipoproteina size isoforms microalbuminuric nondiabetic subjects have an increased risk of cardiovascular disease which is not explained by standard risk factors in diabetic patients microalbuminuria is associated with increased lipoproteina concentrations we have determined lipoproteina concentrations and duplicate measures of albumin excretion rate on two occasions separated by around 3 years in 125 europid subjects aged 4075 years without hypertension or glucose intolerance and in 49 offspring aged 1540 years the apolipoproteina isoform size the major genetic determinant of lipoproteina concentration was also determined there were no differences in lipoproteina concentration between the 42 subjects who were microalbuminuric on either or both samples at screening median 94 mgdl 20th and 80th percentiles 26 and 463 mgdl and the 79 who had been normoalbuminuric at both collections median 109 mgdl 20th and 80th percentiles 29 and 530 mgdl p 058 lipoproteina concentrations were not significantly different between subjects with or without microalbuminuria at recell p 055 or between those with or without microalbuminuria classified by mean albumin excretion rate in either collection p 024 and p 073 respectively there were no significant relationships between albumin excretion rate as a continuous variable and lipoproteina concentration or between changes in the two variables over 3 years the microalbuminuric and normoalbuminuric subjects had similar distributions of size isoforms there were also no differences in lipoproteina concentration or isoform distribution between offspring of microalbuminuric and of normoalbuminuric subjects in conclusion we found no evidence that microalbuminuric subjects with normal blood pressure and normal glucose tolerance have elevated concentrations of lipoproteina to explain their increased cardiovascular risk