could zi have a role in dbs for parkinsons disease an observational study to optimize dbs target localization deep brain stimulation dbs of the subthalamic nucleus stn is a wellrecognized intervention for parkinsons disease pd we used leaddbs a toolbox facilitating dbs electrode reconstructions and computer simulations based on postoperative mri and ct imaging to investigate the interaction and followed benefits of electrical field generated by stndbs and surrounding areas such as caudal zona incerta czi thirtytwo pd patients treated with directional stndbs in the period 20162018 at the walton center nhs foundation trust were retrospectively recruited their mri and ct imaging were analyzed with leaddbs to measure the volume of tissue activated vta considering the clinical outcome based on the updrs iii score improvement of 6265 at 6 months follow up we found a vta intersection of 215 with motor stn and 617 with czi these observations may support the contribution of czi deep stimulation to improve clinical outcome of pd patients treated with dbs promoting the intriguing path of dual targeting