creactive protein as a marker of the surgical stress reduction within an eras protocol enhanced recovery after surgery in colorectal surgery a prospective cohort study background the aim of this study is to evaluate the effectiveness of an enhanced recovery after surgery protocol eras in relation to reduce the systemic inflammatory response sir to surgery using creactive protein crp in the first pod1 second pod2 and third pod3 postoperative daymethods we enrolled 121 patients eras group that underwent elective colorectal surgery with eras and compared them with 135 patients preeras group that had undergone surgery prior to the implementation we made a univariate analysis to compare the crp values in pod1 pod2 and pod3 between preeraseras group laparoscopicopen surgery and the presence or not of clavien dindo complications multivariable lineal regression was used to assess if the eras had a decreasing effect on the crp in pod1 pod2 and pod3 and was adjusted by age male sex use of laparoscopy and complicationsresults the presence of complications was independently associated with an increase in crp values in pod1 pod2 and pod3 laparoscopy in pod1 and pod2 and eras in pod2 was independently associated with a decrease in crp valuesconclusion the analysis shows an increase in sir measured as a crp value in those patients that had complications the sir decreased with laparoscopy in pod1 and pod2 and with eras in pod2