stigmasterol alleviates cutaneous allergic responses in rodents the therapeutic potential of stigmasterol a natural steroid alcohol with established immunemodulatory properties was assessed on allergic cutaneous responses we examined its suppressive effect on immunoglobulin e igemediated active cutaneous anaphylaxis aca compound 4880 c4880induced pruritus and irritant dermatitis induced by 12otetradecanoylphorbol13acetate tpa stigmasterol at 10100mgkg significantly inhibited aca with reduction in reaction area and concentration of the extravasated evans blue dye given at 50 and 100mgkg stigmasterol significantly inhibited c4880induced scratching behaviour when compared to salinetreated c4880injected control skin histopathology of injected sites confirmed that stigmasterol reduced mast cell trafficking and degranulation associated with c4880induced pruritus stigmasterol controlled inflammatory features such as ear skin oedema and neutrophilia and also reduced serum levels of tnf induced by topical application of tpa epidermal layer thickening and inflammatory cell infiltration of ear skin tissue were significantly reduced by stigmasterol taken together stigmasterol demonstrates significant potential as a molecule of interest in allergic skin disease therapy