the analgesic and anticonvulsant effects of piperine in mice piperine is the major active principal of black pepper in traditional medicine black pepper has been used as an analgesic antiinflammatory agent and in the treatment of epilepsy this study was conducted to evaluate the in vivo analgesic and anticonvulsant effects of piperine in mice the analgesic and anticonvulsant effects of piperine were studied in mice using acetic acidinduced writhing tail flick assay pentylenetetrazole ptz and picrotoxin picinduced seizures models the intraperitoneal ip administration of piperine 30 50 and 70 mgkg significantly inhibited p001 the acetic acidinduced writhing in mice similar to the effect of indomethacin 20 mgkg ip in the tail flick assay piperine 30 and 50 mgkg ip and morphine 5 mgkg ip caused a significant increase p001 in the reaction time of mice pretreatment of animals with naloxone 5 mgkg ip reversed the analgesic effects of both piperine and morphine in the tail flick assay piperine 30 50 and 70 mgkg ip and standard drugs valproic acid 200 mgkg ip carbamazepine 30 mgkg ip and diazepam 1 mgkg ip significantly p001 delayed the onset of ptzand picinduced seizures in mice these findings indicate that piperine exhibits analgesic and anticonvulsant effects possibly mediated via opioid and gabaergic pathways respectively moreover piperine being the main constituent of black pepper may be contributing factor in the medicinal uses of black pepper in pain and epilepsy