poor preoperative left ventricular function is associated with decreased insulin sensitivity during cardiac surgery objective to investigate the association between preoperative left ventricular ejection function lvef and wholebody insulin sensitivity during cardiac surgerydesign a prospective nonrandomized trialsetting a tertiary care hospital settingparticipants patients undergoing elective cardiac surgeryinterventions consenting nondiabetic patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass cpb were assigned either to a group with normal lvef ef55 or one with low lvef ef45 as assessed by coronary angiography insulin sensitivity was assessed by the hyperinsulinemicnormoglycemic clamp technique before and towards the end of cpb the association between lvef and insulin sensitivity was tested using student ttestresults one hundred forty patients were studied with 48 patients in the low and 92 patients in the normal lvef group patient demographics were similar in both groups except for preoperative lvef p0001 before cpb patients with normal lvef showed higher insulin sensitivity when compared to patients with low lvef p 004 insulin sensitivity decreased towards the end of cpb p0001 in both groups resulting in similar valuesconclusions poor preoperative left ventricular function is associated with reduced insulin sensitivity before the onset of cpb in cardiac surgery