effect of highdose etodolac on renal function previous studies from our laboratory have demonstrated transient effects on renal function by etodolac 200 mg bid the current study assessed the effects of a larger dose of etodolac 500 mg bid to explore the time course of its renal effects and to determine whether the transient effect would become more prolonged with a larger dose we studied 10 normal subjects and nine patients with renal insufficiency examining the effects of the first 500 mg dose of etodolac as well as 4 days of bid administration in both groups etodolac transiently decreased fractional excretions of sodium and chloride and urinary prostaglandin e2 in patients etodolac also transiently decreased inulin and paraaminohippuric acid clearances and urinary 6ketoprostaglandin f1 alpha chronic administration caused no changes in renal function in either group in summary in this relatively small group of patients highdose etodolac caused only transient fully reversible effects on renal function the cumulative effect of which was negligible