boundary element method for reconstructing absorption and diffusion coefficients of biological tissues in dotmicroct imaging the functional information the absorption and diffusion coefficients as well as the structural information of biological tissues can be provided by the dotdiffuse optical tomographmicroct in this paper we use boundary element method to calculate the forward problem of dot based on the structure prior given by the microct and then we reconstruct the absorption and diffusion coefficients of different biological tissues by the levenbergmarquardt algorithm the method only needs surface meshing reducing the complexity of calculation in addition it reconstructs a single value within an organ which reduces the illposedness of the inverse problem to make reconstruction results have good noise stability this indicates that the boundary element methodbased reconstruction can serve as an new scheme for getting absorption and diffusion coefficients in dotmicroct multimodality imaging