pharmacologic hemostasis in laparoscopy topical epinephrine facilitates cholecystectomy bleeding may become a major impediment to accurate and safe dissection by laparoscopy the traditional maneuvers of pressure dumping irrigation and aspiration frequently applied during open procedures to maintain a clear field of dissection are cumbersome through laparoscopy several pharmacologic agents have been used topically or by local injection to stop bleeding or to prevent excessive blood loss during surgical procedures they include calcium alginate aluminum salts silver nitrate formalin and coagulating agents like thrombin and collagens all of which leave a layer of damaged tissue or foreign material on the surface epinephrine and vasopressin have been employed mostly by local injections we report the use of topical epinephrine applied before and during the dissection of the cystic duct and artery area in the course of laparoscopic cholecystectomy a 38inch gauze sponge impregnated with a 110000 epinephrine solution was used to blanch the tissues and to bluntly dissect the cystic duct and artery it was also used to control minor bleeding in the gallbladder fossa the prophylactic bleeding control with topical epinephrine proved to be an easy and safe maneuver and greatly facilitated the dissection of the most critical areas during laparoscopic cholecystectomy this technique may be applicable to laparoscopic dissection for other procedures