lipoic acid and amlodipineperindopril combination potentiate the therapeutic effect of mesenchymal stem cells on isoproterenol induced cardiac injury in rats cardiac injury is a dangerous disease and become a greater issue in the forthcoming decades the ultimate goal is to prevent the progression of heart failure and apoptotic processes cardiac tissue may regenerate itself but to certain extent depending on the number of resident stem cells that is limited thus research had been focused on bone marrow derived stem cells bmmscs as a promising therapy in different types of tissues including the heart this study is designed not only to assess the therapeutic effect of bmmscs but also to improve their therapeutic effect in combination with antioxidant lipoic acid ala and antihypertensive therapeutic drug form ap against isoproterenolinduced cardiac injury and compared with that of bmmscs alone cardiac injury was induced in 70 male rats by isoproterenol iso was injected sc for four consecutive days experimental animals were divided into six isotreated groups beside a control non treated one the six isotreated groups were divided into iso group isobmmscs group isoala group isoap group isoalaap group and isoalaapbmmscs group the last five groups were treated with the examined materials after one week of iso injection isoproterenol significantly increased serum ckmb ldh activities troponin1 and tnf oxidative stress is evidenced by the increased mda no and caspase3 activity associated with significant reduction of gsh content and sod activity in cardiac tissue furthermore mrna expression of nfb and inos were significantly up regulated and enos mrna expression was down regulated administration of bmmscs ala and ap alone significantly mitigated the induced cardiac injury concomitant administration of ala and ap after bmmscs induced a more pronounced improving effect on cardiac functions in conclusion the concomitant administration of ala and ap after bmmscs infusion increases the cellular antioxidant levels of cardiac tissue that improves the repairing function of bmmscs