hemorrhage in a cat caused by inhibition of factor xi plasma thromboplastin antecedent a coagulation profile from a 5yearold neutered male cat with severe epistaxis revealed an intrinsic coagulation defect characterized by prolonged activated partial thromboplastin time with normal bleeding time platelet count and prothrombin time subsequent factor xi analyses using bovine factor xideficient plasma revealed factor xi deficiency hematologic and clinical studies on the cat failed to reveal an underlying disease process that might have resulted in acquired factor xi inhibition modulation of lithiumpilocarpineinduced status epilepticus by adenosinergic agents effect of adenosinergic agents were investigated in lithiumpilocarpineinduced status epilepticus se in rats adenosinergic agents such as adenosine 50 100 mgkg 2choloroadenosine 1 2 mgkg carbamazepine 20 80 mgkg n6cyclohexyladenosine 1 2 mgkg and dipyridamole 10 20 mgkg produced theophyllinesensitive protective effects as they dosedependently prolonged the latencies for onset of forelimb clonus with rearing pretreatment with ro 54864 20 mgkg ip did not offer any protection these results indicate the possible involvement of adenosinergic mechanism in preventing lithiumpilocarpineinduced se and mortality