antibacterial activity against lactamase producing methicillin and ampicillinresistants staphylococcus aureus fractional inhibitory concentration index fici determination background the present study reports the antibacterial capacity of alkaloid compounds in combination with methicillin and ampicillinresistants bacteria isolated from clinical samples the resistance of different bacteria strains to the current antibacterial agents their toxicity and the cost of the treatment have led to the development of natural products against the bacteria resistant infections when applied in combination with conventional antimicrobial drugsmethod the antibacterial assays in this study were performed by using inhibition zone diameters mic mbc methods the timekill assay and the fractional inhibitory concentration index fici determination on the whole fifteen grampositive bacterial strains mrsaarsa were used negative control was prepared using discs impregnated with 10 dmso in water and commercially available methicillin and ampicillin from alkom laboratories ltd were used as positive reference standards for all bacterial strainsresults we noticed that the highest activities were founded with the combination of alkaloid compounds and conventional antibiotics against all bacteria strains then results showed that after 7 h exposition there was no viable microorganism in the initial inoculumsconclusion the results of this study showed that alkaloid compounds in combination with conventional antibiotics methicillin ampicillin exhibited antimicrobial effects against microorganisms tested these results validate the ethnobotanical use of cienfuegosia digitata cav malvaceae in burkina faso moreover this study demonstrates the potential of this herbaceous as a source of antibacterial agent that could be effectively used for future health care purposes