relation of neutrophiltolymphocyte and platelettolymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography background atherosclerosis is a chronic systemic inflammatory disease neutrophiltolymphocyte ratio nlr and platelettolymphocyte ratio plr are systemic inflammatory markers that are correlated with poor cardiovascular outcomesaim to explore the relation of nlr and plr with severity of coronary artery disease cadmethods the study population consisted of 180 consecutive patients who underwent elective coronary angiography cag while 100 patients 22 female mean age 606 126 years had abnormal cag 80 patients 44 female mean age 572 109 years had normal cag nlr and plr were calculated as the ratio of neutrophil count to lymphocyte count and as the ratio of platelet count to lymphocyte count respectivelyresults although age distribution was similar between the two groups p 0073 female gender was significantly higher in the normal cag group p 0001 patients with abnormal cag had significantly higher nlr and plr when compared to patients with normal cag 37 26 vs 22 17 p 0001 and 1259 723 vs 1026 338 p 0027 respectively nlr and plr were significantly correlated with syntax score and gensini score in logistic regression analyses only nlr odds ratio 1576 confidence interval 11982072 p 0001 was an independent predictor of cad an nlr of 23 or higher predicted the cad with a sensitivity of 66 and specificity of 70conclusions nlr and plr seem to be a simple method to predict severity of cad in patients undergoing elective cag and it may be part of cardiovascular examination before cag