endoscopic and surgical therapy of hemorrhagic duodenal and stomach ulcer the aim of this prospective clinical study was to evaluate whether a combination of the endoscopic hemostasis together with fibrin sealing and consecutive conservative therapy could reduce the frequency of recurrent bleedings thus the number of operations without adversely influencing the prognosis of the disease 134 patients admitted to the surgical and medical hospital of the university of ulm between 11990 and 11992 with bleeding gastroduodenal ulcers took part in this study all patients were treated endoscopically by hypertonic saline solution plus epinephrine and fibrin sealant if initial endoscopic hemostasis was not achieved patients were operated within 6 h after admission patients with successful initial endoscopic hemostasis were treated conservatively and underwent control endoscopy after 24 and 48 h in 23 patients the initial endoscopic hemostasis was not successful they had to be operated immediately in 111 patients endoscopic hemostasis was achieved 20 of these patients had acute bleeding ulcers forrest ia b 66 showed stigmata of fresh bleedings forrestiia bleeding primary endoscopic hemostasis was achieved in 856 of all patients treated 144 of patients n 16 developed a recurrent bleeding during the observation period verified by gastroscopy half of these patients had an acute bleeding at the first gastroscopy forrestia forrestib bleeding recurrent bleeding became apparent between day 1 and 6 after admission to the hospital two patients refused surgical intervention the other 14 were operated immediatelyabstract truncated at 250 words