r 71 nr 10 5year survival after the interval which elapsed so far 91 as compared with 2 similar groups of subjects under 65 years meeting the criteria of hd theraphy with asct but treated only by conventional polychemotheraphy 1991 1995 and 1996 2000 r 24 and 32 nr 42 and 23 5year survival 46 and 68 of the patients in the group of 148 patients from the period of 19912000 the patients had as regards remission r more favourable results as compared with patients with nr concerning the prognosis m 63 vs22 months 5year and 10year survival 53 vs 17 and 17 vs 0 of patients p 00000conclusion from the submitted analysis ensured that during the period form 1959 2000 in patients with mutiple myeloma in central and northern moravia as a result of the application of modern methods of chemotheraphy and supporting treatment a significant improvements of results of conventional treatment occurred with a more than 5 fold prolongation of so far assessable median values of survival 8 44 months and longterm 10year survival of almost one sixth of the patients the real asset of hd theraphy with transplantation of asct will be revealed by analyses made after a longer time interval