the therapeutic effects of cholecystokinin octapeptide on rat liver and kidney microcirculation disorder in endotoxic shock objectives our previous studies demonstrated that pretreatment with cholecystokinin octapeptide cck8 could alleviate endothelial cell injury and reverse abnormal vascular reactivity as well as reduce lpsinduced inflammation cascades which suggested that cck8 plays a potential role in antiendotoxic shock the present study aimed to determine the therapeutic effects of cck8 on rat liver and kidney microcirculatory perfusion disorder under endotoxic shock es conditionsmaterials and methods spraguedawley rats were induced to lethal endotoxic shock by an injection of lps cck8 was administered 30min after lps injection either a specific cck1r antagonist or cck2r antagonist was injected before cck8 treatment the mean arterial pressure map liver and kidney microcirculatory perfusion and heart rate hr were recorded with a multichannel data acquisition system the serum concentrations of alanine aminotransferase alt and creatinine cr were measured and the histopathological changes in the liver and kidney were also observedresults administration of cck8 significantly delayed the lpsinduced decreases in not only the liver and kidney microcirculation perfusion but also the hr the pathology changes induced by lps in the liver and kidney tissues were significantly mitigated in the lpscck8 group the levels of alt and cr in the serum of the lpscck8 group were obviously lower than those in the lps group in addition the specific antagonist at the cck2 receptor cck2r abrogated the action of cck8 significantlyconclusions these results indicated that cck8 has potential therapeutic effects on microcirculation failure in an es rat model via the cck2 receptor