management of a burn sustained as a result of contact with 2400 degrees f molten metal a case of burns of the right leg caused by immersion in molten metal at 2400 degrees f is presented management by standard excision and grafting yielded a good result the importance of protective garments is stressed pyrido pyrimidinones as selective agonists of the high affinity niacin receptor gpr109a optimization of in vitro activity pyrido pyrimidinones are selective agonists of the human high affinity niacin receptor gpr109a hm74a they show no activity on the highly homologous low affinity receptor gpr109b hm74 starting from a high throughput screening hit the in vitro activity of the pyrido pyrimidinones was significantly improved providing lead compounds suitable for further optimization