polysaccharidepolyaminoacid composite scaffolds for modified dna release in this work composite polymeric films or sponges based on hyaluronic acid ha covalently crosslinked with alphabetapolyn2hydroxyethyl2aminoethylcarbamatedlaspartamide pe have been prepared and characterized as local gene delivery systems in particular hape scaffolds have been loaded with pedna interpolyelectrolyte complexes employing pe as a macromolecular crosslinker for ha and as a nonviral vector for dna in vitro studies showed that hape films and sponges have high compatibility with human dermal fibroblasts and they give a sustained dna release whose trend can be easily tailored by varying the crosslinking ratio between ha and pe electrophoresis analysis and transfection studies on b16f10 cells revealed that dna is released as a complex with pe and it retains its bioactivity