tumor budding and poorlydifferentiated cluster in prognostication in stage ii colon cancer comparison between tumor budding tb and poorlydifferentiated clusters pdc for prognostication in stage ii colon cancer was not extensively studied in literature in this retrospective study we assessed tb according to the consensus statement in 2016 and pdc in 135 stage ii colon adenocarcinoma resection specimens counting of tb and pdc was performed on he slides highgrade tb bd3 10 tumor buds in 0785mm2 and highgrade pdc grade 3 10 were found in 20 and 17 of cases respectively highgrade tb was associated with pt4 p0008 and presence of lymphovascular invasion p0001 there was correlation between tb and pdc grades p0001 in which both grades were the same or one grade apart in majority of the cases 95 both tb and pdc correlated with 5year diseasespecific survival dss and overall survival os dss for tb 89 bd1 73 bd2 52 bd3 p0001 dss for pdc 88 grade 1 72 grade 2 61 grade 3 p0021 survival curves of stage ii colon cancer could be further stratified by tb and pdc logrank tests tb p0001 pdc p0009 combining tb and pdc grades into single grading system highgrade bd3g2 bd2g3 bd3g3 lowgrade other combinations was found to have strong correlation with both 5year dss and os both p0001 our study has confirmed tb and pdc as independent prognostic factors in stage ii colon cancer and might help selecting highrisk patients for adjuvant chemotherapy