correlation of polymorphism in il6 gene promoter with bmi inflammatory factors and pathogenesis and progression of chd this study was aimed to explore the correlation between il6 gene promoter polymorphisms and coronary heart disease chd by investigating the polymorphisms 572gc 597ga in il6 gene promoter area body mass index bmi inflammatory factors and other biochemical parameters in han nationality of north china the genotypes of il6 gene promoter572gc 597ga were detected by fluorescent probe hybridization with fluorescent resonance energy transfer and melting curve techniques in 194 chd patients and 123 healthy people as control the effects of genotype on plasma lipids apoproteins high sensitive creactive protein hscrp and bmi were also studied logistic regression was performed to observe the risk factors of chd the results indicated that genotype of il6 gene promoter 597ga polymorphism in 7 cases were ga and were gg in others whereas no aa genotype had been found and no associations between polymorphism of il6 gene 597ga bmi and inflammatory factors were found no differences had been found between the frequencies of il6 gene 572gc genotypes and alleles in chd and control group however significant difference was found between the g allele carrier gggc and nong allele carrier cc of chd and control group p00425 in the control group median levels of systolic blood pressure of g allele carrier were significant higher than nong allele carrier p002 among all the subjects median levels of bmi hscrp and systolic blood pressure in the group of g allele carrier were significantly higher than that in the group of nong allele carrier p values were 0026 0022 0005 respectively multivariate logistic regression analysis showed that age triglyceride sex high blood pressure apoprotein c2 cholesterol and lipoproteina were the risk factors for chd and apoprotein a1 was a protective factor the g allele of il6 gene 572gc has been not found to be a risk factor for chd it is concluded il6 gene 597ga polymorphism is not correlated with the susceptibility to chd il6 gene 572gc polymorphism may be correlated with the susceptibility to chd in han nationality of north china the mechanisms may be related with the changes of bmi hscrp and blood pressure levels resulted from the polymorphism of il6 572gc