oxidizing agents in hair cosmetic products and methods of their identification and determination hydrogen peroxide and oxidazing agents are used in hair lightening products in oxidants of permanent wave products hair dyeing products and toothpastes in accordance with the cosmetic directive of the european union council directive of 27 july 1976 r annex iii p 12 maximum permitted concentration in the finished above mentioned cosmetic products is 12 in hair care preparations 4 in skincare preparations 2 in nail hardening the method identification and determination hydrogen peroxide and oxidazing agents is very useful for control cosmetic products on market atypical clinical variants of hypothyrosis timely diagnosis of hypothyrosis was noted in 34 of patients only considerable difficulties in the diagnosis of disease were associated with an atypical course of disease in a number of patients the authors discuss some problems of a clinical picture of hypothyrosis with arterial hypertension sympaticoadrenal crises polyserositis pituitary adenoma amenorrhealactorrhea premature puberty in boys they also discuss pathogenesis of sexual advancement of a number of pubertal features in van wykgrambooh syndrome hennesross syndrome was identified as a separate entity