chronic myeloid leukemia in the netherlands a populationbased study on incidence treatment and survival in 3585 patients from 1989 to 2012 objective to assess the impact and results of treatment of cml in the general population we conducted a populationbased nationwide study on 3585 cml patients diagnosed between 1989 and 2012 in the netherlandsmethods patient demographics were obtained from the netherlands cancer registry information on age gender year of diagnosis first treatment and date of death were recorded overall survival os was adjusted for death rates in the normal populationresults incidence in males decreased slightly from 12 per 100000 person years py in 19892000 to 09 in 20012012 for females incidence remained stable with 07 per 100000 py in both periods incidence was age dependent and highest in males in the last decades of life treatment before 2000 mainly consisted of chemotherapy while after 2007 tki use was 88 fiveyear relative survival was only 36 before the introduction of tkis but significantly increased to 79 after the introduction of tkiconclusions this study gives insight into cml incidence treatment and survival in routine care in the netherlands although os improved since the introduction of tkis there is still room for further improvement