evaluation of a prognostic scoring system based on the systemic inflammatory and nutritional status of patients with locally advanced nonsmallcell lung cancer treated with chemoradiotherapy systemic inflammation and poor nutritional status have a negative effect on the outcomes of cancer here we analyzed the effects of the pretreatment inflammatory and nutritional status on clinical outcomes of locally advanced nonsmallcell lung cancer nsclc patients treated with chemoradiotherapy we retrospectively reviewed 89 patients with locally advanced nsclc treated with chemoradiotherapy between july 2006 and june 2013 serum creactive protein crp was assessed as an inflammatory marker and serum albumin body mass index bmi and skeletal mass index were assessed as nutritional status markers the relationships between these markers and overall survival os were assessed the median os was 246 months 95 confidence interval ci 194393 months during followup 58 patients 65 had disease recurrence and 52 patients 58 died in multivariate cox hazard analysis crp levels and bmi approached but did not achieve a significant association with os p 0062 and 0094 respectively recursive partitioning analysis identified three prognostic groups based on hazard similarity crpbmi scores 0 crp 03 mgdl 1 crp 03 mgdl and bmi 185 kgm2 and 2 crp 03 mgdl and bmi 185 kgm2 the crpbmi score was significantly associated with os p 0023 patients with scores of 0 1 and 2 had median os of 393 245 and 145 months respectively and the scores also predicted the probability of receiving salvage treatment after recurrence the crpbmi score is thus a simple and useful prognostic marker of clinical outcome for patients with locally advanced nsclc treated with chemoradiotherapy