endo180 expression with cofunctional partners mt1mmp and uparupa is correlated with prostate cancer progression endo180 cd280 mrc2 uparap regulates collagen remodelling and chemotactic cell migration through cooperation with membrane type1 matrix metalloproteinase mt1mmp urokinasetype plasminogen activator receptor upar and urokinasetype plasminogen activator upa one hundred and sixty nine prostate tissue sections clinically graded as benign prostatic hyperplasia bph n29 or prostate cancer pca with gleason scores indicating low or 734 n26 intermediate 7438 n96 or high 910 n19 clinical risk were immunofluorescently stained for endo180 pancytokeratin pck vimentin mt1mmp and uparupa quantification of endo180pck and endo180pck cells in entire tissue cores revealed stromal p00001 and epithelial p00001 upregulation of endo180 in pca compared to bph epithelial endo180 expression was significantly different between the three clinical risk groups of pca p005 correlations with mt1mmp and uparupa confirmed the functionality of endo180 during pca progression this molecular evaluation is the first step in the exploration of endo180 in pca diagnosis and therapy