33bimorpholine derivatives as a new class of organocatalysts for asymmetric michael addition new nalkyl33bimorpholine derivatives ipbm were revealed to be efficient organocatalysts for the asymmetric direct michael addition of aldehydes to nitroolefins and a vinyl sulfone in these transformations using ipbm 14adducts were afforded in high yields with good to high levels of diastereo and enantioselectivity the stereochemical outcome of the reaction could be explained by an acyclic synclinal model reaction see text teratogenic effects of endotoxin on the golden hamster gramnegative urinary tract infections in pregnant women have been implicated as causes of maternal endotoxemia and a subsequent higher incidence of malformations in their offspring a study was performed to evaluate the effects of endotoxin on the development of the golden hamster endotoxin was shown to be extremely embryolethal at higher doses and to produce several malformations at lower doses the pregnant hamster and its developing embryos were observed to be far more sensitive to endotoxin than species examined by other investigators