role of inducible nitric oxide synthase in acute gastric mucosal damage in stress in rats in groups of female wistar rats someted to stress by immobilization and immersion in 18 degrees c water during 6 hrs the role of nitric oxide no in its pathophysiologic was studied agonist and antagonist of the isoforms constitutive no synthase cnos and of the inducible no synthase inos were used was found that the overdose of larginine aggravated of stress acute gastric lesions the agonist of inos the nmda and the antagonists dexamethasone and aminoguanidine were used the nmda aggravated the stress acute gastric lesions in contrast dexamethasone and aminoguanidine given a evident protection of the gastric mucosa in stress was concluded that the production of no given by inos play a role important in the pathophysiologic in stress acute gastric lesions