lemierres syndrome one rare diseasetwo case studies what is known and objective lemierres syndrome is often misdiagnosed as a common cold or viral infection fusobacterium necrophorum is the most common causative organism the recommended treatment regimen is 6 weeks of a betalactam antibiotic along with metronidazolecase description we present two cases of lemierres syndrome with internal jugular vein thrombophlebitis and positive blood cultures for f necrophorum the first case was successfully treated with 6 weeks of a betalactam antibiotic and 4 weeks of metronidazole while the second case was successfully treated with 4 weeks of a betalactam antibiotic and 2 weeks of metronidazolewhat is new and conclusion two cases of lemierres syndrome were treated successfully with only 24 weeks of metronidazole therapy shorter duration of metronidazole therapy should be explored in future studies