synthesis and evaluation of hexahydropyrrolo34disoxazole46diones as antistress agents a series of 23diphenyl5naphthalen1yl4h233a566ahexahydropyrrolo34disoxazole46dione derivatives were synthesized via 13dipolar cycloaddition of azomethine noxides with nnaphthylmaleimide the pyrroloisoxazole derivatives were assigned cis and trans configurations 3a and 3b with respect to proton c3h on azomethinic carbon on the basis of their 1h nmr the reaction proceeds through cis endo addition rule indicating the predominance of cis isomer the cis and trans isomers of a prototype compound 3aie compound 3aa and compound 3ab were evaluated for antistress activity in immobilizationinduced acute stress compound 3aa 5 and 10 mgkg and compound 3ab 10 mgkg attenuated immobilization stressinduced behavioral alterations in swiss albino mice suggesting that pyrroloisoxazole may serve as lead molecule for the development of antistress agents