tissuespecific profiling of oxidative stressassociated transcriptome in a healthy mouse model oxidative stress is a common phenomenon and is linked to a wide range of diseases and pathological processes including aging tissuespecific variation in redox signaling and cellular responses to oxidative stress may be associated with vulnerability especially to agerelated and chronic diseases in order to provide a basis for tissuespecific difference we examined the tissuespecific transcriptional features of 101 oxidative stressassociated genes in 10 different tissues and organs of healthy mice under physiological conditions microarray analysis results which were consistent with quantitative polymerase chain reaction qpcr results showed that catalase gpx3 and gpx4 were most highly regulated in the liver kidney and testes we also found the tissuespecific gene expression of sod1 liver and kidney sod2 heart and muscle and sod3 lung and kidney the current results will serve as a reference for animal models and help advance our understanding of tissuespecific variability in oxidative stressassociated pathogenesis