preliminary evaluation of altered brain microstructure in the emotioncognition region in children with haemophilia a a diffusional kurtosis imaging study aim using diffusional kurtosis imaging dki to assess the impact of emotional disorders on microstructural changes of the brain in children with haemophilia amaterials and methods diffusional kurtosis imaging was acquired from haemophilia a n 22 and controls n 22 using a 3t scanner a regression analysis of frontal cingulate hippocampus insula and amygdala regions of interest rois was conducted clinical data and results of psychological tests were collected a paired ttest was used to analyse the differences between the two groups rois and the spearman test was used to analyse the correlation between rois and psychological tests or clinical dataresults fractional anisotropy fa in the left middle cingulate and right hippocampus mean diffusion md in the frontal lobe right anterior cingulate and right middle cingulate showed varying degrees of increase in the roi compared to controls p 0003 md in the frontal lobe and the course of disease p 005 fa in the right hippocampus and the social score of the selfconsciousness scale p 001 had a positive correlationconclusion our study is the first to evaluate the relationship between emotion disorders and cognitive changes in the microstructure of the brain in children with haemophilia a suggesting that dki provides more information about tissue microstructural changes than do the conventional image method and traditional psychological tests