does noise stress modulate effects of smokingnicotine mood vigilance and eeg responses effects of smoking multiple cigarettes on eeg vigilance and subjective state were assessed in a repeated measures design where noise level high versus minimal was crossed with nicotine dose quasiad lib own versus 10 mg ftc nicotine machinedelivered dose versus 005 mg ftc nicotine machinedelivered dose vigilance was increased by nicotine but not by noise and there was no noise by dose interaction effects of nicotine on eeg varied as a function of dose noise hemisphere time and eyesopen versus eyesclosed condition smoking normal nicotine delivery 0911 mg ftcestimated cigarettes resulted in decreases in percentages of delta and theta eeg magnitude and increased percentage beta1 eeg magnitude across conditions and time changes in alpha and theta magnitude were dependent on eyes being open versus closed hemispheric asymmetries varied as a function of noise and time consistent with inverted u models effects of nicotine on eeg were clearly stimulant during the quiet conditions while there were minimal to no differences between nicotine doses during the highnoise conditions the failure of nicotine to modify mood is interpreted in terms of bioinformational models of nicotines subjective effects