inhibitor1 phosphatase activity in vascular smooth muscle the histoneh1 and polylysine stimulated latent phosphorylase phosphatase characterized by a molecular weight of 260000 in gel filtration and 130000 in sucrose density gradient centrifugation has been identified as a major inhibitor1 phosphatase in vascular smooth muscle its substrate protein phosphatase inhibitor1 was also shown to be present in the same tissue following treatment with betamercaptoethanol the enzyme dissociates into a lower molecular weight 38000 form with a higher specific activity evidence for multiple routes of speech production in a case of fluent aphasia a case study is reported of a 24year old woman who developed fluent aphasia with superior reading relative to auditory comprehension following herpes simplex encephalitis her language disturbance showed exceptional features oral reading repetition and naming to confrontation were severely impaired and yet her spontaneous speech recovered to be relatively intact these features are not consistent with wernickes aphasia pure word deafness or any classic aphasic syndromes these findings indicate the presence of several routes for phonological output that may be differentially impaired