emergence of sequence type 252 enterobacter cloacae producing ges5 carbapenemase in a czech hospital st252 enterobacter cloacae producing ges5 carbapenemase was isolated in a czech hospital blages5 was part of a novel class 1 integron in1406 which also included a new allele of the aada15 gene cassette in1406 was located on a cole2like plasmid pecl35771cz 6953bp expanding the synthesis of new transsulfonamide platinum complexes cytotoxicity sar fluorescent cell assays and stability studies in this manuscript we describe the synthesis of new transnsulfonamide platinum complexes and their antiproliferative activity gi50 m in human solid tumors cells the structure activity relationships sar with different new synthesized complexes by variation in ligand halogen and also in the stereochemistry of the ligand has been studied solubility and stability studies have also been carried out as well as fluorescent cell assays in order to clarify the final target in the tumor cells