attenuation of oxidative stress and hepatic damage by white butterfly clerodendrum volubile leaves in streptozotocininduced diabetes in rats background the negative impact of diabetes on the liver is well documented the white butterfly clerodendrum volubile leaf has been used in traditional practices for the treatment of various diseases such as hypertension diabetes and rheumatism but without scientific validation this work was designed to evaluate the hepatoprotective properties of clerodendrum volubile leaves on oxidative stress in streptozotocin stzinduced diabetes in rats methods the rats were divided into ten groups of five rats each diabetes was induced by a single injection of stz 65 mgkg body weight ip while the c volubile extract at the respective doses of 50 100 and 200 mgkg body weight was given to diabetic and nondiabetic rats orally for 14 days metformin 100 mgkg body weight served as the positive control biochemical assays were conducted on the plasma for hematological parameters along with hepatic marker damages and antioxidant enzyme determination in vivo to assess hepatic injury results the diabetic control rats showed significant increase p005 in marker enzymes aspartate aminotransferase alanine aminotransferase alkaline phosphatase and malondiadehyde with reduction in reduced glutathione glutathione peroxidase superoxide dismutase catalase activities and plasma total protein content likewise there were alterations in hematological indices in the diabetic control rats when compared with the normal control however treatment with c volubile caused a reversal of the above parameters towards normal levels thereby suggesting the modulating effect of the extract on oxidative stress which may be a result of the high polyphenolic content and antioxidant capacity conclusions the protection of the liver tissues and the modulation of oxidative stress in stz diabetic rats compare favorably to metformin a standard antidiabetic drug