digestant effects of a new digestive enzyme capsule excelase on jejunectomized and pancreatojejunectomized beagle dogs authors transl the digestant effects of a new digestive capsule excelase containing sanactase proctase meicelase olipase2s and pancreatic digestive enzyme ta were investigated in vivo jejunectomy and pancreatojejunectomy were performed to cause an artificial disturbance of gastrointestinal digestion and absorption in beagle dogs absorption of protein and fat was measured using chromic oxide as an indicator excelase 3 capsulesdogday was given orally to beagle dogs 1 week after each operation for 7 weeks changes in body weight and absorption of protein and fat were observed during the administration the decrease in body weight of dogs treated with excelase fully recovered however that of controls remained even 8 weeks after the surgery absorption of protein and fat in the groups of dogs treated with excelase was greatly improved as compared with controls the digestant effects of excelase on percent absorption of protein and fat were more manifest in pancreatojejunectomized dogs than in jejunectomized dogs these results indicate that excelase is effective for gastrointestinal disturbances of digestion and absorption the digestant effects of excelase on starch protein and cellulose were also investigated in vitro using a gastrointestinal model