prognostic significance of serum antiepsteinbarr virus antibodies in nasopharyngeal carcinoma objective this study was aimed to investigate the association between serum against epsteinbarr virus ebv antibodies levels and nasopharyngeal carcinoma npc patients prognosismethods blood samples from 140 primary npc patients without metastasis were collected before and after treatment the titers of vcaiga and eaiga were detected by immunoenzyme assay and the levels of na1iga and rtaigg were detected by enzymelinked immunosorbent assay elisa all patients received consequent followup and longterm efficacy and survival assessmentresults posttreatment serum levels of vcaiga eaiga na1iga and rtaigg in npc patients significantly decreased than those before treatment while had significantly higher than those in control individuals p 005 the progressionfree survivals were significantly lower in patients with higher pretreatment vcaiga or 1 320 and eaiga or 180 levels than in those with lower vcaiga 1 320 and eaiga 1 80 levels respectively 618 vs 865 613 vs 865 p 0001 cox regression model analysis demonstrated that pretreatment serum vcaiga level was an independent risk factor for progressionfree survival hr 380 p 0001conclusion antiebv vcaiga and eaiga might provide information regarding the prognosis of npc patients