effects of age and noise exposure on proxy measures of cochlear synaptopathy although there is strong histological evidence for agerelated synaptopathy in humans evidence for the existence of noiseinduced cochlear synaptopathy in humans is inconclusive here we sought to evaluate the relative contributions of age and noise exposure to cochlear synaptopathy using a series of electrophysiological and behavioral measures we extended an existing cohort by including 33 adults in the age range 37 to 60 resulting in a total of 156 participants with the additional older participants resulting in a weakening of the correlation between lifetime noise exposure and age we used six independent regression models corrected for multiple comparisons in which age lifetime noise exposure and highfrequency audiometric thresholds were used to predict measures of synaptopathy with a focus on differential measures the models for auditory brainstem responses envelopefollowing responses interaural phase discrimination and the coordinate response measure of speech perception were not statistically significant however both age and noise exposure were significant predictors of performance on the digit triplet test of speech perception in noise with greater noise exposure unexpectedly predicting better performance in the 80db sound pressure level spl condition and greater age predicting better performance in the 40db spl condition amplitude modulation detection thresholds were also significantly predicted by age with older listeners performing better than younger listeners at 80db spl overall the results are inconsistent with the predicted effects of synaptopathy