evaluation of pantoprazole formulations in different dissolution apparatus using biorelevant medium purpose the study was developed to compare the in vitro dissolution profiles of pantoprazole cas 102625707 formulations in both the united states pharmacopeia usp apparatus 2 and 3 by applying biorelevant medium moreover an in vitroin vivo relationship was proposed considering in vivo data from a previously published studymethods in vitro dissolution profiles were evaluated in biorelevant medium in usp apparatus 2 and 3 and the dissolution curves were either compared by the similarity factor f2 or a modelindependent approach the fraction of drug dissolved in vitro in apparatus 2 was compared with the fraction of drug absorbed in vivo which was obtained from a retrospective in vivo study an in vitroin vivo relationship analysis was then applied to elucidate the overall absorption characteristics of formulationsresults the dissolution profiles of formulations demonstrated similar disposition in biorelevant medium in both usp apparatus 2 and 3 the dissolution profiles were described by f2 model in apparatus 2 and weibulls function in apparatus 3 the vitroin vivo relationship analysis showed that the formulations exhibited permeability ratelimiting absorptionconclusion biorelevant medium in both usp apparatus 2 and 3 may be used as a tool to predict in vivo disposition of formulations of pantoprazole furthermore it can be argued that biowaiver can be granted for enteric coated formulations of pantoprazole on the basis of in vitro dissolution profile