association of transporter associated with antigen processing tap gene polymorphisms in donors with acute cellular rejection in living donor liver transplantation background aims despite improvements in immunosuppressive therapy acute cellular rejection acr remains an important cause of mortality and graft loss in patients undergoing liver transplantation recently associations between gene polymorphisms and the incidence of acr have been reported though few studies have investigated those polymorphisms in donors transporter associated with antigen processing tap1 and tap2 are involved in major histocompatibility complex mhc class i antigenmediated processing and presentation to cytotoxic cd8 t lymphocytes the aim of this study was to determine whether tap1 and tap2 gene polymorphisms in the donor have affected on acr incidence in living donor liver transplantation ldltmethods we examined 155 ldlts treated at nagoya university or kyoto university from 2004 to 2009 and analyzed the gene polymorphisms of tap1 pile333val tap1 pasp697gly tap2 parg651cys and tap2 pgln687stopresults thirtyseven recipients developed early acr of the investigated gene polymorphisms the tap1 p697gly allele in donors was associated with incidence of early acr or297 95ci 133663 p0008conclusions the tap1 p697gly allele in donors was associated with increased incidence of early acr following ldlt the tap1 697 polymorphism in donors can be genotyped prior to ldlt which may contribute to individualize immunosuppression strategies for recipients and donor selection