the effects of highdose amlodipinebenazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy background this study compared the efficacy and safety of amlodipinebenazepril 1040 mgday and 1020 mgday with amlodipine 10 mgday in patients whose blood pressure bp was not adequately controlled with amlodipine monotherapymethods after a leadin period with amlodipine monotherapy 812 nonresponder patients mean sitting diastolic bp or 95 mmhg were randomized to one of three treatment groups ambulatory bp monitoring was conducted in 276 patientsresults treatment with amlodipinebenazepril 1040 mgday and 1020 mgday resulted in a decrease of mean sitting systolic and mean sitting diastolic bp by 133127 mmhg and 121116 mmhg respectively compared with monotherapy 6685 mmhg p 00001 both combinations resulted in more responders than monotherapy 74 and 65 vs 54 p 00001 and p 00085 respectively amlodipinebenazepril 1040 mgday and 1020 mgday decreased ambulatory systolic and diastolic bp by 9967 mmhg and 7452 mmhg compared with monotherapy p 00001 the incidence of pedal edema was lower in the amlodipinebenazepril combinations compared with monotherapy 45 55 vs 92 respectively pns no significant metabolic sideeffects were noted among the combination groupsconclusion amlodipinebenazepril combinations were well tolerated and resulted in significant bp reductions and better bp responder rates than amlodipine monotherapy