physicochemical and histomorphometric evaluation of zinccontaining hydroxyapatite in rabbits calvaria the aim of this study was to characterize the physicochemical properties and bone repair after implantation of zinccontaining nanostructured porous hydroxyapatite scaffold nznha in rabbits calvaria nznha powder containing 2 wtwt zinc and stoichiometric nanostructured porous hydroxyapatite nha control group were shaped into disc 8 mm and calcined at 550 c two surgical defects were created in the calvaria of six rabbits nznha and nha after 12 weeks the animals were euthanized and the grafted area was removed fixed in 10 formalin with 01 m phosphate buffered saline and embedded in paraffin n10 for histomorphometric evaluation in addition one sample from each group n2 was embedded in methylmethacrylate for the sem and eds analyses the thermal treatment transformed the nznha disc into a biphasic implant composed of zncontaining ha and zncontaining tricalcium phosphate znhazntcp the xrd patterns for the nha disc were highly crystalline compared to the znha disc histological analysis revealed that both materials were biologically compatible and promoted osteoconduction xray fluorescence and meveds of nznha confirmed zinc in the samples histomorphometric evaluation revealed the presence of new bone formation in both frameworks but without statistically significant differences p005 based on the wilcoxon test the current study confirmed that both biomaterials improve bone repair are biocompatible and osteoconductive and that zinc 2wt did not increase the bone repair additional in vivo studies are required to investigate the effect of doping hydroxyapatite with a higher zn concentration