oestrogen receptor alpha gene intronic polymorphisms and autoimmune myasthenia gravis in caucasian women autoimmune myasthenia gravis is a disorder with a complex pathomechanism in which sex hormones in particular oestrogen have long been considered to play a role here we report the result of a casecontrol study which evaluated the association of two oestrogen receptor alpha gene polymorphisms with myasthenia gravis in caucasian patients pvuii rs2234693 and xbai rs9340799 restriction fragment polymorphisms of the oestrogen receptor alpha gene were analyzed in 113 female myasthenia patients and 184 female controls distribution of these polymorphisms was compared with pcrrflp patients were divided into groups according to their oestrogen receptoralpha genotypes and acetylcholine receptor antibody status and age of onset were compared between the groups we found no significant difference between any of the groups implying that these two polymorphisms probably do not play a role in the pathomechanism of myasthenia gravis in caucasian women