cancer burden trends in umbria region using a joinpoint regression introduction the analysis of the epidemiological data on cancer is an important tool to control and evaluate the outcomes of primary and secondary prevention the effectiveness of health care and in general all cancer control activitiesmaterials and methods the aim of the this paper is to analyze the cancer mortality in the umbria region from 1978 to 2009 and incidence from 19942008 sex and sitespecific trends for standardized rates were analyzed by joinpoint regression using the surveillance epidemiology and end results seer softwareresults applying the jointpoint analyses by sex and cancer site to incidence spanning from 1994 to 2008 and mortality from 1978 to 2009 for all sites both in males and females a significant joinpoint for mortality was found moreover the trend shape was similar and the joinpoint years were very close in males standardized rate significantly increased up to 1989 by 123 per year and significantly decreased thereafter by 131 among females the mortality rate increased in average of 078 not significant per year till 1988 and afterward significantly decreased by 092 per year incidence rate showed different trends among sexes in males was practically constant over the period studied not significant increase 014 per year in females significantly increased by 149 per year up to 2001 and afterward slowly decreased 071 ns estimated annual percent change eapcconclusions for all sites combined trends for mortality decreased since late 80s both in males and females such behaviour is in line with national and european union data this work shows that even compared to health systems that invest more resources the umbria public health system achieved good health outcomes