aspartate aminotransferase to platelet ratio can reduce the need for transient elastography in chinese patients with chronic hepatitis b in the absence of liver biopsy and transient elastography te aspartate aminotransferase to platelet ratio apri fibrosis4 score fib4 and gammaglutamyl transpeptidase to platelet ratio gpr are simple and inexpensive methods for the detection of liver fibrosisaims we compared the performance of apri fib4 and gpr scores against te in predicting the presence of liver fibrosis and cirrhosis determined the optimal cutoff values for fibrosis and cirrhosis prediction and reviewed the need for further te assessment in resourcelimited areas in chinamethods te and basic laboratory tests were performed in 2014 consecutive patients with chronic hepatitis b chb and then compared to apri fib4 and gprresults for the detection of significant fibrosis the areas under the receiver operating characteristic auroc curves for apri fib4 and gpr were 083 075 and 077 respectively for the detection of cirrhosis the auroc curves for apri fib4 and gpr were 090 084 and 084 respectively the cutoff of apri was 035 with 78 sensitivity and 63 negative predictive value npv to exclude significant fibrosis f 2 at an apri of 06 results showed a 94 specificity 100 positive predictive value ppv and 79 positive likelihood ratio plr in detecting significant fibrosis thus patients with an apri of 06 demonstrated correct prediction of liver fibrosis these results translated to 1250 out of the 2014 patients avoiding the need for te with a diagnostic accuracy of 80conclusions the apri score accurately assessed fibrosis and reduced the need for te in almost twothirds of chinese patients with chb