sericin improves heart and liver mitochondrial architecture in hypercholesterolaemic rats and maintains pancreatic and adrenal cell biosynthesis hypercholesterolaemia is well known to be associated with mitochondrial dysfunction subsequently leading to multiple organ failure similar to other natural products sericin is a candidate for adjunctive therapy in hyperlipidaemic conditions however the cholesterollowering mechanisms of sericin are multifactorial and controversial here a highcholesterolfed rat model with or without sericin treatment was established using a dosage of 1000mgkgday for 30 days blood lipid profiles oxidative stress markers superoxide dismutase sod malondialdehyde mda nuclear factor erythroid 2related factor nrf2 dysmorphic mitochondria in relation to fission dynaminrelated protein1 drp1 and fusion guanosine triphosphatase mutated in dominant optic atrophy opa1 markers and biosynthetic markers aquaporin aqp1 tubulin4 tb4b in the pancreas and adrenal gland were evaluated the results showed that sericin reduced blood cholesterol and increased highdensity lipoprotein hdl by acting against oxidative stress hypocholesterolaemic and antioxidant conditions further preserved heart and liver mitochondrial architecture however this protection was not exhibited in the kidney where a high level of renal mitophagy indicating by lc3 upregulation was presented the steps of ultrastructural alteration of mitochondria from degenerative changes to necrosis were also demonstrated sericin also conserved aqp1 and tb4b levels in the exocrine pancreatic acinar cells and zona glomerulosa cells which were positively correlated with serum lipase hdl antioxidative markers and mitochondrial integrity the present study revealed that sericin not only has antioxidant capacity but also balances pancreatic and adrenal cell biosynthesis especially lipase activity which may have played an important role in improving lipid dysregulation in the hypercholesterolaemic rat model leading to the reduction of dysmorphic mitochondria particularly in the heart and liver