nonspecific ulcer of the colon a report on 12 endoscopically diagnosed cases report on 12 patients with nonspecific ulcers of the colon diagnosed by colonscopy and biopsy in 10 patients the course was favorable with conservative management in 2 patients the symptoms were aggravated in both patients this was due to a penetrating malignant tumour diagnosed at laparotomy a few weeks later it is proposed that nonspecific ulcers of the colon should be managed conservatively further investigations and laparotomy are indicated only when symptoms progress the discovery and optimization of benzimidazoles as selective nav the voltage gated sodium channel nav18 has been postulated to play a key role in the transmission of pain signals core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole nav18 blockers subsequent optimization allowed the identification of compound 9 pf06305591 as a potent highly selective blocker with an excellent preclinical in vitro adme and safety profile