isolated oculomotor nerve palsy in a child caused by an internal carotid aneurysm common causes for acquired isolated oculomotor nerve palsy in children are trauma inflammation and neoplasia we report a case of isolated oculomotor nerve palsy in a 13yearold boy secondary to intracranial carotid aneurysm studies on topical antiinflammatory agents i synthesis and vasoconstrictive activity of corticosteroid 17succinyl esters a series of 17succinyl derivatives of four corticosteroids was prepared they were tested for vasoconstrictive activity in humans using 9 alphafluoro11 beta 21dihydroxy16 betamethyl17 alphavaleryloxy14pregnadiene320dione betamethasone 17valerate bv as a standard the activities of the 21chloro 17methylsuccinate compounds 6a 6c and 6d were greater than that of bv a structureactivity relationship study showed that the activities of the 21chloro 17methylsuccinates were more potent than those of the corresponding 21esters