doubleblind and randomised parallel study of minocycline 100mg mynocine vs roxithromycin 300mg rulid in the treatment of seasonal acute bronchitis in clinical practice 46 general practitioners of the vicinity of nancy carried out a randomised parallel and double blind study comparing the efficacity and the tolerance of two drugs roxithromycin rulid 300 mg per day and minocycline mynocine 100 mg per day in the treatment of adult acute bronchitis in clinical practice 124 patients were included from january 1992 to june 1992 efficacy of the treatment was estimated by both practitioners and patients to be good and excellent at the same time in 90 to 95 per cent of cases in the two groups clinical tolerance was estimated to be excellent 90 per cent of cases in the two groups roxithromycine and minocycline are effective and well tolerated in the treatment of adults acute bronchitis in clinical practice among the two drugs we prefer to use minocycline because it is 25 to 5 times less expensive than roxithromycine