induction chemotherapy followed by cisplatin or cetuximab concomitant to radiotherapy for laryngealhypopharyngeal cancer longterm results of the tremplin randomised gortec trial background in europe induction chemotherapy ict followed by radiotherapy is preferred to conventional chemoradiotherapy to avoid total laryngectomy in patients with laryngealhypopharyngeal cancer in comparison with conventional radiotherapy bioradiotherapy with cetuximab significantly improves locoregional control rates lcrs and overall survival os without any increase in unmanageable toxicitymethods patients included had untreated nonmetastatic stage iiiiv laryngealhypopharyngeal invasive squamous cell carcinoma good responders after three cycles of docetaxelcisplatin5fluorouracil tpfict docetaxel and cisplatin 75 mgm2 each on day 1 and 5fluorouracil 750 mgm2day on days 15 every 3 weeks were randomised to receive radiotherapy 70 gy with concurrent cisplatin 100 mgm2day on days 1 22 and 43 of radiotherapy or cetuximab 400 mgm2 of loading dose 250 mgm2week during radiotherapy the primary endpoint was larynx preservation the secondary endpoints were laryngooesophageal dysfunctionfree survival ledfs lcr and osresults a total of 153 patients were enrolled among 126 tpfict responders 116 were randomised to receive either cisplatin n 60 or cetuximab n 56 the median followup was 775 months fiveyear os rates were 666 95 confidence interval ci 054079 versus 669 95 ci 054079 p 09 respectively fiveyear lcrs were 798 95 ci 695900 versus 678 95 ci 551805 p 018 fiveyear ledfs was 622 95 ci 497748 versus 562 95 ci 430694 p 038 late grade iiiiv salivary gland and laryngeal toxicity occurred in 103 versus 98 and 68 versus 118 of patients receiving cisplatinradiotherapy versus cetuximab respectivelyconclusions no significant difference in ledfs was observed between the two arms tpfict followed by conventional chemoradiotherapy or cetuximab was feasible and longterm toxicity was not statistically different between the two arms ledfs appears as a relevant endpoint