results of preoperative chemoradiotherapy for patients with advanced cancer of the nasal cavity and paranasal sinuses objectives curative treatment of nasal cavity and paranasal sinus cancer is challenging due to the proximity to critical anatomical structures the purpose of this study was to analyze the impact of trimodality therapy with preoperative chemotherapy and reduceddose radiotherapy followed by organpreserving surgery for treating patients with nasal cavity and paranasal sinus cancermethods this retrospective study included all 156 patients diagnosed with sinonasal cancer in western sweden between 1986 and 2009 we determined the treatment selection pattern and treatment outcomes for 79 patients treated with preoperative chemoradiotherapyresults squamous cell carcinoma was the most common histology the fiveyear overall survival was 54 and 85 of these patients had t3 or t4 tumors the fiveyear cumulative incidence rate of local recurrence was 32 the fiveyear overall survival in patients with squamous cell carcinoma and adenocarcinoma was 45 and 76 respectively the median preoperative radiation dose was 48gy orbital exenteration was performed in 7 of patientsconclusions preoperative chemoradiotherapy may be beneficial for patients with advanced sinonasal cancer when primary radical surgery is challenging survival outcomes were comparable to outcomes reported in the literature despite conservative surgery and relatively low radiation doses in patients with locally advanced tumors