genomewide screen identifies new candidate genes associated with artemisinin susceptibility in plasmodium falciparum in kenya early identification of causal genetic variants underlying antimalarial drug resistance could provide robust epidemiological tools for timely public health interventions using a novel natural genetics strategy for mapping novel candidate genes we analyzed 75000 high quality single nucleotide polymorphisms selected from highresolution wholegenome sequencing data in 27 isolates of plasmodium falciparum we identified genetic variants associated with susceptibility to dihydroartemisinin that implicate one region on chromosome 13 a candidate gene on chromosome 1 pfa0220w a ubp1 ortholog and others pfb0560w pfb0630c pff0445w with putative roles in protein homeostasis and stress response there was a strong signal for positive selection on pfa0220w but not the other candidate loci our results demonstrate the power of fullgenome sequencingbased association studies for uncovering candidate genes that determine parasite sensitivity to artemisinins our study provides a unique reference for the interpretation of results from resistant infections