effect and mechanism of aerial parts of salvia miltiorrhiza effective constituents on glycolipid metabolism of high sugarinduced drosophila melanogaster metabolic disorder model to evaluate the effect and mechanism of aerial parts of salvia miltiorrhizasm on high sugarinduced drosophila melanogaster metabolic disorder model the levels of glucose triglyceride and protein in sm were detected nymphosis time was recorded and the reliability of metabolic disorder model as well as the mechanism of aerial parts of sm were evaluated based on metabonomics the results showed that the levels of glucose and triglyceride in model group were significantly higher than those in normal control groupp005 as compared with the model group the glucose level was significantly decreased in gliclazideglz group sm mediumsmm and highsmh dose groupsp005 p001 the triglyceride level was significantly decreased in glz group and smh groupp005 p001 by principal component analysispca and partial least squares discriminant analysisplsda the metabolic level of model ones was recovered to a certain degree after intervention by aerial parts of sm seventeen marker compounds and four major metabolic pathways were obtained by screening differential metabolites comparing literature and retrieving the database the aerial parts of sm may regulate glycolipid metabolism through the impact on histidine metabolism glycerophospholipid metabolism pentose and glucuronate interconversions cysteine and methionine metabolism and glycerolipid metabolism extract from aerial parts of sm can regulate the glycolipid metabolism of d melanogaster metabolic disorder model and make it return to normal condition this paper provides reference for the value discovery and resource utilization of the aerial parts of s miltiorrhiza