status epilepticus induced by lithiumpilocarpine in the immature rat does not change the longterm susceptibility to seizures the causal relationship between early seizures and subsequent temporal lobe epilepsy has not yet been established prospective clinical studies reported that seizures occurring early in life rarely result in hippocampal sclerosis likewise in most experimental models early seizures occurring before the end of the second postnatal week do not lead to neuronal damage and subsequent epilepsy in some models this early event decreases latency sensitivity and threshold to seizures in the present study we induced lithium and pilocarpine status epilepticus se in 10dayold p10 rats the goal of this study was to determine whether this early life se altered the sensitivity to convulsants such as pentylenetetrazol 20 and 25 mgkg picrotoxin 25 and 40 mgkg and kainate 5 and 8 mgkg during adulthood the occurrence of electrographic seizures spikeandwave discharges swd andor of behavioral seizures was monitored there was no difference in latency to and duration of swds and seizures between lithiumsaline and lithiumpilocarpine exposed rats thus se induced by lithium and pilocarpine early in life does not change the sensitivity to limbic seizures or seizures induced by gabaa antagonists during adulthood