closed loop ventilation mode in intensive care unit a randomized controlled clinical trial comparing the numbers of manual ventilator setting changes background there is an equipoise regarding closedloop ventilation modes and the ability to reduce workload for providers on one hand some settings are managed by the ventilator but on another hand the automatic mode introduces new settings for the usermethods this randomized controlled trial compared the number of manual ventilator setting changes between a full closed loop ventilation and oxygenation mode intelliventasv and conventional ventilation modes volume assist control and pressure support in intensive care unit icu patients the secondary endpoints were to compare the number of arterial blood gas analysis the sedation dose and the user acceptance sixty subjects with an expected duration of mechanical ventilation of at least 48 hours were randomized to be ventilated using intelliventasv or conventional modes with a protocolized weaning all manual ventilator setting changes were recorded continuously from inclusion to successful extubation or death arterial blood gases were performed upon decision of the clinician in charge user acceptance score was assessed for nurses and physicians once daily using a likert scaleresults the number of manual ventilator setting changes per 24 hperiod per subject was lower in intelliventasv as compared to conventional ventilation group 5 47 versus 10 717 manuals settings per subject per day p0001 the number of arterial blood gas analysis and the sedation doses were not significantly different between the groups nurses and physicians reported that intelliventasv was significantly easier to use as compared to conventional ventilation p0001 for nurses and p001 for physiciansconclusions for mechanically ventilated icu patients intelliventasv significantly reduces the number of manual ventilator setting changes with the same number of arterial blood gas analysis and sedation dose and is easier to use for the caregivers as compared to conventional ventilation modes