clinical effect and metabolism of ssulfonated immunoglobulin in 7 patients with congenital humoral immunodeficiency 7 patients with primary humoral immunodeficiency were given an ssulfonated igg preparation 100 mgkg iv at intervals of 34 weeks for treatment of or prophylaxis against infection the clinical effects and metabolism of ssulfonated igg were studied no side reactions attributable to ssulfonated igg occurred in any of the patients the ssulfonated igg was completely transformed into intact igg within 24 h after administration and had a mean halflife of 21 days comparable to that of intact igg complete restoration of igg fc fragment activity occurred within 24 h following injection as assessed by reversed passive cutaneous anaphylaxis