treatment of endometrial hyperplasia with goserelin depot an lhrh analog nineteen patients with simple endometrial hyperplasia presenting metrorrhagia or menometrorrhagia were treated with 4 injections of goserelin depot one every 4 weeks 1219 patients were refractory after previous medical therapy the treatment with goserelin depot resulted in a complete remission of the symptoms occurring within the first month of treatment and still present after a median followup of 12 months and in the normalization of the histological profile no patient experienced clinically relevant side effects significant lateralisation of supratentorial icp after blunt head trauma after blunt head trauma simultaneous left and right hemispheric intracranial pressure icp monitoring revealed a pressure gradient of about 30 mmhg persisting until the 5th day after the accident equilibrating thereafter icp was elevated over the radiologically more compressed hemisphere the supratentorial space seems to allow considerable interhemispheric pressure gradients as a consequence epidural icp monitoring should be performed over the hemisphere with signs of greater compression