immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer in our previous study oral adjuvant combination chemotherapy of 5fluorouracil cyclophosphamide mitomycin c and predonisolone femp after curative resection of operable breast cancer with vascular invasion in the tumor andor in the metastatic lymph node was found to be more effective than one course of mitomycin c or cyclic course of mitomycin c in the present study we have assessed the efficacy of proteinbound polysaccharide psk or levamisole lms in addition to femp between january 1980 and december 1990 227 operable breast cancer patients with vascular invasion in the tumor andor in the metastatic lymph node were randomized into femp femp lms or femp psk the risk ratio was lower in the femp psk group compared to the femp group in diseasefree survival or overall survival there was no significant difference between the three groups however the survival curve of the femp psk group tended to be better than that of the femp grouplogrank p 00706 generalized wilcoxon p 00739 side effects were observed at a low incidence but they were mild and tolerable immunochemotherapy using psk improved the prognosis of patients with operable breast cancer with vascular invasion