a multifaceted coating on titanium dictates osteoimmunomodulation and osteoangiogenesis towards ameliorative osseointegration a multifaceted coating for hard tissue implants with favorable osteogenesis angiogenesis and osteoimmunomodulation abilities would be of great value since it could improve osseointegration and alleviate prosthesis loosening however to date there are few coatings that fully satisfy these criteria herein we describe a microporous tio2 coating decorated with hydroxyapatite ha nanoparticles that is generated by microarc oxidation of pure titanium ti and followed annealing by altering the annealing temperature it is possible to simultaneously tune the coatings physical morphology and wettability and chemical composites and crystallinity properties a coating produced with microarc oxidization mao with an annealing temperature of 650c mao650 exhibits numerous favorable physicochemical properties such as hybrid micronano morphology superhydrophilicity and highly crystalline ha nanoparticles in vitro experiments reveal that the mao650 coating not only supports proliferation and differentiation of both osteoblasts and endothelial cells but also inhibits the inflammatory response of macrophages and enables a favorable osteoimmunomodulation to facilitate osteoangiogenesis in vivo evaluation mirrors these results and shows that the mao650 coating results in ameliorative osseointegration when compared with the pristine mao coating these data highlight the profound effect of surface physicochemical properties on the regulation of osteoangiogenesis and osteoimmunomodulation in the enhancement of osseointegration