terapeutic potential of microencapsulated sertoli cells in huntington disease introduction immune dysfunction promoted by proinflammatory cytokines plays a pivotal role in neurodegeneration associated with huntingtons diseaseaims the aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of sertoli cells in huntingtons diseasemethods the experimental r62 mouse model of huntingtons disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine sertoli cells and lifespan motor performance and striatal inflammatory pattern have been evaluatedresults the results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine sertoli cells uniquely improved performances and extended the life expectancy of r62 huntingtons disease mice by immune dysfunction modulation in brainconclusions this study highlights the immunomodulatory and trophic role of sertoli cells that could be of help in the treatment of neurodegenerative disorders