The main feud for the SmackDown! brand was between Batista, and World Heavyweight Champion The Great Khali. The feud began in July when Khali laid out an open challenge to the "SmackDown!" roster, which was answered by Batista. Shortly after, the feud began revolving around the World Championship when Khali won a twenty-man battle royal on "SmackDown!", winning the vacant title. At The Great American Bash, Khali won against Batista and Kane in a triple threat match, while at SummerSlam, Batista beat Khali by disqualification after Khali used a chair. At Unforgiven, Batista won against Khali and Rey Mysterio in a triple threat match to win the championship. Khali exercised his rematch clause for a match at No Mercy, to take place in his specialty match, the Punjabi Prison match.
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