In 2023, he played J. Robert Oppenheimer in the Christopher Nolan movie "Oppenheimer". To prepare for the role, Murphy lost weight to match Oppenheimer's appearance. He researched Oppenheimer's life and took inspiration from David Bowie's appearance in the 1970s for his role. He won a Golden Globe Award, Screen Actors Guild Award a BAFTA Award, and an Academy Award for this role.
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