Playing "Guitar Hero III Mobile" is similar to playing other games in the "Guitar Hero" series. "Mobile" uses 3 frets instead of 5. Each column of numbered keys on a phone's keypad is a fret. The numbered keys used are "1", "4", and "7" for green notes, "2", "5", and "8" for red notes, and "3", "6", and "9" for yellow notes. Once the note(s) reach the bottom, the player must play the note(s) by pressing or holding down the number key(s) in order to score points. Players can turn on Star Power to get more points by the "*" (star) button on the keypad or the "OK" button in the center of the directional pad.
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