All the seeded teams made it through the first round apart from the teams of Aisam-ul-Haq Qureshi and Květa Peschke who lost to Rennae Stubbs and Chris Guccione and Moody and Reymond who lost to Horia Tecău and Bethanie Mattek-Sands. The second round witnessed the number one seeds Bryan and Huber withdraw and the defending champions, Paes and Black go out to Paul Hanley and Chan Yung-jan after two tiebreak sets. The quarterfinals saw no upsets as Nestor and Srebotnik, Zimonjic and Kirlienko, Hanley and Chan and Tecau and Mettek–Sands made the semifinals. In the semifinals Nestor and Srebotnik won in straight sets against Zimonjic and Kirilenko. Their opponents in the final were Hanley and Chan after they won a match tiebreak 11–9 against Tecau and Mettek–Sands. The final came down to a match tiebreak which the number two seeds, Nestor and Srebotnik won. It was Nestor's second Australian Open mixed title while for Srebotnik it was her first.
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