After his return, he assisted a prominent physician named Louis Serre to help fight against a major plague outbreak in Marseille, and then tackled further disease outbreaks on his own in Salon-de-Provence and in Aix-en-Provence, the capital of Provence. In 1547, he settled in Salon-de-Provence in the house which still exists today where he married a rich widow named Anne Posarde. With her he had six children (three daughters and three sons). In 1556 and 1557, he and his second wife acquired a one-thirteenth share in a huge canal project. The project was organised by Adam de Craponne to construct the Canal de Craponne to irrigate Salon-de-Provence, which was largely waterless, and the nearby Désert de la Crau from the river Durance.= = = Trough (meteorology) = = =
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