A smaller group of these Native Americans were known as the Sepasco Indians. This name was used for Native Americans in the Sepasco area, which is now known as Rhinebeck. The word "Sepasco" probably came from the tribe's word for "little river" or "stream", which is "sepuus". After the Civil War, only a few of the Sepasco were left. The last Sepasco Indian died in 1867 in a hut near Lake Sepasco. By 1685, a trail known as the Sepasco Trail was formed by the Sepasco people. This trail started at the Hudson River and went east through the village of Rhinebeck. It ended at Lake Sepasco. Part of the trail from Rhinebeck to Lake Sepasco follows about the same path that is today taken by Route 308.
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