Saif studied architecture and political science. He holds a PhD from the London School of Economics. Saif presides the Gaddafi International Foundation of Charitable Associations. In 2011, the International Criminal Court issued an arrest warrant against Saif. The court said that Saif may have committed crimes against humanity. According to the court, the Gaddafi regime used torture, killed people and raped women to incite the population to support the regime.
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