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For this question, the correct answer is choice 2. While I've already known
the meaning of "いいかげんにしなさい" is "enough!" and "act properly!", I still have no
idea about the reason that choice 1 is incorrect.

I looked up for some example sentences of "えんりょ"

As what I know, both "しなさい" and "ください" have nearly the same meanings. (They
just differ in the expressions and the strength of emotion.)

If "おタバコはご遠慮ください" is correct, then "おタバコはご遠慮しなさい" also seems to be correct for
me.

Can anyone explain the usage of "遠慮" in details for me?

[![correct
answer:2](https://i.stack.imgur.com/xyKoD.jpg)](https://i.stack.imgur.com/xyKoD.jpg)
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definitions sentence
Is ”えんりょしなさい” correct
By ください the speaker is generally asking the listener for a favor. しなさい on the
other hand is more of a stern order.

In most Japanese situations this phrase is used to ask customers or audience
to refrain from something. Unless you are in the position to be commanding
others then you would be seeing

> （タバコ歩きは）ご遠慮ください。 Please refrain (from smoking while walking).

rather than

> もっと遠慮しなさい。 Hold back more (won't you).

as the speaker will more often use the humble form of speech (to hopefully
elicit a favorable response).
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In adding to keithmaxx's answer, 遠慮する means "to refrain from doing by taking
someone into consideration".

For example, when you are invited out to eat by your friend and the friend
says that he will treat you, if you order many expensive cuisines, you would
be said ちょっと遠慮しろよ.

いいかげんにしなさい would be more natural in this case because the person who said that
seems to just want him to stop doing a game.
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I think Keithmaxx, bjorn and yuiichi tam’s answers’ are accurate.

In addition to that, the former sentence is “まだゲームをしているの？” which could imply
you were already requested/advised to stop playing the video-game before.
Therefore the correct answer in the book can be いいかげんにしなさい. which is more
imperative than 遠慮しなさい。and more effective to notify that you are already
beyond the limit.
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