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I guess there is a slight/subtle difference between the two, but also
wondering what is the preferred/acceptable way to express this to someone who
is a good friend (not just an acquaintance). Ideally it should show some
concern but without being forceful or commanding.
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2014-07-04T00:50:32.647
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2014-07-04T11:16:50.953
2014-07-04T02:20:23.053
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question
expressions
How to say don't tire/wear yourself out?
無理しないでください is one very common way of saying something along the lines of
"don't do more than you can".

It's also used to mean "don't wear yourself out" in a physical sense, but can
be used in virtually any context.
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2014-07-04T01:06:36.990
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2014-07-04T01:06:36.990
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answer
The expression「無理しないで」is used in most situations for showing concern for
someone who may expose herself/himself in doing an "impossible" activity that
pushes them to their limits while a more refined 「ご無理なさいませんよう、ご自愛ください」could
also be used. 「ご無理なさらずに」 which literally translates to "don't do the
impossible" is adopting 「なさる」as an elegant way of saying「する」。

If the intention is to express concern for someone healing and recovering
their health from sickness one could use 「お大事に」as a neutral and all-situation
expression or a less formal 「早くよくなって下さいね」。
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2014-07-04T11:16:50.953
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answer