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My best guess at this point is that this means "you definitely can't escape".

The English translation (which I've learned to take with a grain of salt)
translates it as "Don't run off!"

In context, the addressee clearly is running away.

My understanding is that じゃん is a contraction of じゃない but has a meaning of its
own. This comes mainly from Tae Kim's guide here:

<http://www.guidetojapanese.org/learn/grammar/slang>

Where he writes:

> Though derived from 「じゃない」, 「じゃん」 is always used to confirm the positive.
>
> ...
>
> Hopefully, you can see that 「じゃん」 is basically saying something along the
> lines of, “See, I’m right, aren’t I?”

The proposed “See, I’m right, aren’t I?” translation of じゃん doesn't seem to
fit very well here as far as translating this into a natural sounding English
translation, which gave me some doubt. But I'm thinking it can carry a sense
of "definitely" or "absolutely" instead. Grammatically, it's a rhetorical
question in Japanese, but it doesn't translate to a rhetorical question in
English.

Actually, writing this question made me more confident about this (and I
changed my mind half way through), but can anyone confirm?
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grammar colloquial-language
Meaning of 「逃げることないじゃん！」
I would translate it as "No need to run away, right?"

> Does the "no need" part come from ことない?

Yes.

> Can verb+ことない by itself have that meaning

I would say verb+ことない has the connotation "there's no need to + verb".

> the じゃん part, in addition to adding the "right?"

じゃん is a colloquialism for "ではないか” (= isn't it?.)

All in all I would utter the expression to convey that I am dissatisfied with
someone's escapism.
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Perhaps you could think of it like "The event that you will run away doesn't
exist." The "じゃん" is simply rhetorical and doesn't negate the meaning or
anything like that. Now, I found the expression 逃げることなく on
thesaurus.weblio.jp, and upon inspection of synonym expressions, it simply
means "without running away". If you wanted a more English sounding
translation, maybe you could go for something like "There won't be any running
away will there." Also, having a context for this (i.e. the situation, who
said it, to whom, etc) would help.
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