Im reading a comic and this is the heading of the chapter. I looked up the
english chapter and the translation was "Those who know power and solitude.
Know nothing of each other". I'm wondering how they got the second sentence
Know nothing of each other, I can't really deduce that based off the second
sentence
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translation
「強さを、孤独を、知る者たち。それは、変わることは無く。」 How do I interpret 変わる here?
If 強さを、孤独を、知る者たち = Those who know power and solitude.  
And それは、変わることは無く= That will never change  
Then, they will remain in solitude, which means they will not know each other.  
Which is then reworded into "Know nothing of each other"

In a professional translation of literature, the translator will first
understand the content and then write the story in their own natural language.
That means that there will be places where you can't identify a 1 to 1
relationship in the translation between words or even sentences, especially in
the case of English and Japanese. If the overall translation is good, as the
OP has suggested in a comment, I find it very hard to believe this is a
translation mistake. It seems much more likely that the significance of
"solitude" is being emphasized for whatever events happen in the rest of the
story.
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それは変わることは無く means "That never changes", where それ refers to their strength and
solitude. Just in case, this 無く is in the continuative form for [this effect
(see #3)](https://japanese.stackexchange.com/a/60764/5010), and meaning-wise
it's the same as simple 無い. So the second sentence does not mean "knowing
nothing of each other". It's probably a simple mistake, but it may be a valid
free translation based on the broader context, as @chocolate suspects.
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answer